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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IP6K2-SATB2 (FusionGDB2 ID:40027)

Fusion Gene Summary for IP6K2-SATB2

check button Fusion gene summary
Fusion gene informationFusion gene name: IP6K2-SATB2
Fusion gene ID: 40027
HgeneTgene
Gene symbol

IP6K2

SATB2

Gene ID

51447

23314

Gene nameinositol hexakisphosphate kinase 2SATB homeobox 2
SynonymsIHPK2|InsP6K2|PIUSGLSS
Cytomap

3p21.31

2q33.1

Type of geneprotein-codingprotein-coding
Descriptioninositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulatorDNA-binding protein SATB2SATB family member 2special AT-rich sequence-binding protein 2
Modification date2020032720200313
UniProtAcc

Q9UHH9

.
Ensembl transtripts involved in fusion geneENST00000328631, ENST00000340879, 
ENST00000413298, ENST00000432678, 
ENST00000450045, ENST00000436134, 
ENST00000417896, ENST00000431721, 
ENST00000443964, ENST00000446860, 
ENST00000449610, ENST00000453202, 
ENST00000260926, ENST00000417098, 
ENST00000443023, ENST00000457245, 
ENST00000428695, ENST00000484124, 
Fusion gene scores* DoF score13 X 12 X 7=10924 X 6 X 3=72
# samples 207
** MAII scorelog2(20/1092*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IP6K2 [Title/Abstract] AND SATB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIP6K2(48732523)-SATB2(200320819), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIP6K2

GO:0043647

inositol phosphate metabolic process

30624931

HgeneIP6K2

GO:0046854

phosphatidylinositol phosphorylation

10574768


check buttonFusion gene breakpoints across IP6K2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SATB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238-01AIP6K2chr3

48732523

-SATB2chr2

200320819

-


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Fusion Gene ORF analysis for IP6K2-SATB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000328631ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000328631ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000328631ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000328631ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000340879ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000340879ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000340879ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000340879ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000413298ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000413298ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000413298ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000413298ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000432678ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000432678ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000432678ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000432678ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000450045ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000450045ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000450045ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-5UTRENST00000450045ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000328631ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000328631ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000340879ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000340879ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000413298ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000413298ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000432678ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000432678ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000450045ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5CDS-intronENST00000450045ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-5UTRENST00000436134ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-5UTRENST00000436134ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-5UTRENST00000436134ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-5UTRENST00000436134ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-intronENST00000436134ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
5UTR-intronENST00000436134ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000417896ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000417896ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000417896ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000417896ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000431721ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000431721ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000431721ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000431721ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000443964ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000443964ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000443964ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000443964ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000446860ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000446860ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000446860ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000446860ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000449610ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000449610ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000449610ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000449610ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000453202ENST00000260926IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000453202ENST00000417098IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000453202ENST00000443023IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-5UTRENST00000453202ENST00000457245IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000417896ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000417896ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000431721ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000431721ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000443964ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000443964ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000446860ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000446860ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000449610ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000449610ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000453202ENST00000428695IP6K2chr3

48732523

-SATB2chr2

200320819

-
intron-intronENST00000453202ENST00000484124IP6K2chr3

48732523

-SATB2chr2

200320819

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IP6K2-SATB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IP6K2-SATB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48732523/:200320819)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IP6K2

Q9UHH9

.
FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IP6K2-SATB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IP6K2-SATB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IP6K2-SATB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IP6K2-SATB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource