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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPO8-KRT86 (FusionGDB2 ID:40074)

Fusion Gene Summary for IPO8-KRT86

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO8-KRT86
Fusion gene ID: 40074
HgeneTgene
Gene symbol

IPO8

KRT86

Gene ID

10526

3892

Gene nameimportin 8keratin 86
SynonymsRANBP8HB6|Hb1|K86|KRTHB1|KRTHB6|MNX
Cytomap

12p11.21

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionimportin-8RAN binding protein 8imp8ran-binding protein 8keratin, type II cuticular Hb6hair keratin K2.11hard keratin, type II, 6keratin 86, type IIkeratin protein HB6keratin, hair, basic, 6 (monilethrix)type II hair keratin Hb6type-II keratin Kb26
Modification date2020031320200313
UniProtAcc

O15397

O43790

Ensembl transtripts involved in fusion geneENST00000256079, ENST00000538338, 
ENST00000544829, 		ENST00000293525, 
ENST00000423955, ENST00000544024, 
Fusion gene scores* DoF score4 X 5 X 4=806 X 7 X 6=252
# samples 47
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO8 [Title/Abstract] AND KRT86 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIPO8(30837234)-KRT86(52702016), # samples:2
IPO8(30837235)-KRT86(52702017), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IPO8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KRT86 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VP-A87D-01AIPO8chr12

30837235

-KRT86chr12

52702017

+
ChimerDB4PRADTCGA-VP-A87DIPO8chr12

30837234

-KRT86chr12

52702016

+
ChimerDB4PRADTCGA-VP-A87DIPO8chr12

30837235

-KRT86chr12

52702017

+


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Fusion Gene ORF analysis for IPO8-KRT86

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000256079ENST00000293525IPO8chr12

30837234

-KRT86chr12

52702016

+
In-frameENST00000256079ENST00000293525IPO8chr12

30837235

-KRT86chr12

52702017

+
In-frameENST00000256079ENST00000423955IPO8chr12

30837234

-KRT86chr12

52702016

+
In-frameENST00000256079ENST00000423955IPO8chr12

30837235

-KRT86chr12

52702017

+
In-frameENST00000256079ENST00000544024IPO8chr12

30837234

-KRT86chr12

52702016

+
In-frameENST00000256079ENST00000544024IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000538338ENST00000293525IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000538338ENST00000293525IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000538338ENST00000423955IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000538338ENST00000423955IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000538338ENST00000544024IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000538338ENST00000544024IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000544829ENST00000293525IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000544829ENST00000293525IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000544829ENST00000423955IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000544829ENST00000423955IPO8chr12

30837235

-KRT86chr12

52702017

+
intron-3CDSENST00000544829ENST00000544024IPO8chr12

30837234

-KRT86chr12

52702016

+
intron-3CDSENST00000544829ENST00000544024IPO8chr12

30837235

-KRT86chr12

52702017

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256079IPO8chr1230837234-ENST00000544024KRT86chr1252702016+1174662339875178
ENST00000256079IPO8chr1230837234-ENST00000423955KRT86chr1252702016+1105662339875178
ENST00000256079IPO8chr1230837234-ENST00000293525KRT86chr1252702016+14546621253654199
ENST00000256079IPO8chr1230837235-ENST00000544024KRT86chr1252702017+1174662339875178
ENST00000256079IPO8chr1230837235-ENST00000423955KRT86chr1252702017+1105662339875178
ENST00000256079IPO8chr1230837235-ENST00000293525KRT86chr1252702017+14546621253654199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256079ENST00000544024IPO8chr1230837234-KRT86chr1252702016+0.0030569860.99694306
ENST00000256079ENST00000423955IPO8chr1230837234-KRT86chr1252702016+0.0031060790.9968939
ENST00000256079ENST00000293525IPO8chr1230837234-KRT86chr1252702016+0.0064890070.993511
ENST00000256079ENST00000544024IPO8chr1230837235-KRT86chr1252702017+0.0030569860.99694306
ENST00000256079ENST00000423955IPO8chr1230837235-KRT86chr1252702017+0.0031060790.9968939
ENST00000256079ENST00000293525IPO8chr1230837235-KRT86chr1252702017+0.0064890070.993511

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Fusion Genomic Features for IPO8-KRT86


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IPO8chr1230837234-KRT86chr1252702016+0.77745190.22254816
IPO8chr1230837234-KRT86chr1252702016+0.77745190.22254816
IPO8chr1230837234-KRT86chr1252702016+0.77745190.22254816
IPO8chr1230837234-KRT86chr1252702016+0.77745190.22254816

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IPO8-KRT86


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:30837234/chr12:52702016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO8

O15397

KRT86

O43790

FUNCTION: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO8chr12:30837234chr12:52702016ENST00000256079-32522_1021071038.0DomainImportin N-terminal
HgeneIPO8chr12:30837235chr12:52702017ENST00000256079-32522_1021071038.0DomainImportin N-terminal
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569414_486415487.0RegionNote=Tail
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811414_486415487.0RegionNote=Tail
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710414_486415487.0RegionNote=Tail
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569414_486415487.0RegionNote=Tail
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811414_486415487.0RegionNote=Tail
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710414_486415487.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO8chr12:30837234chr12:52702016ENST00000256079-325923_9281071038.0Compositional biasNote=Poly-Glu
HgeneIPO8chr12:30837234chr12:52702016ENST00000544829-121923_9280833.0Compositional biasNote=Poly-Glu
HgeneIPO8chr12:30837235chr12:52702017ENST00000256079-325923_9281071038.0Compositional biasNote=Poly-Glu
HgeneIPO8chr12:30837235chr12:52702017ENST00000544829-121923_9280833.0Compositional biasNote=Poly-Glu
HgeneIPO8chr12:30837234chr12:52702016ENST00000544829-12122_1020833.0DomainImportin N-terminal
HgeneIPO8chr12:30837235chr12:52702017ENST00000544829-12122_1020833.0DomainImportin N-terminal
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569106_417415487.0DomainIF rod
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811106_417415487.0DomainIF rod
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710106_417415487.0DomainIF rod
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569106_417415487.0DomainIF rod
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811106_417415487.0DomainIF rod
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710106_417415487.0DomainIF rod
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837234chr12:52702016ENST00000293525691_106415487.0RegionNote=Head
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837234chr12:52702016ENST0000029352569270_413415487.0RegionNote=Coil 2
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837234chr12:52702016ENST000004239558111_106415487.0RegionNote=Head
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837234chr12:52702016ENST00000423955811270_413415487.0RegionNote=Coil 2
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837234chr12:52702016ENST000005440247101_106415487.0RegionNote=Head
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837234chr12:52702016ENST00000544024710270_413415487.0RegionNote=Coil 2
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837235chr12:52702017ENST00000293525691_106415487.0RegionNote=Head
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837235chr12:52702017ENST0000029352569270_413415487.0RegionNote=Coil 2
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837235chr12:52702017ENST000004239558111_106415487.0RegionNote=Head
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837235chr12:52702017ENST00000423955811270_413415487.0RegionNote=Coil 2
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710107_141415487.0RegionNote=Coil 1A
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710142_151415487.0RegionNote=Linker 1
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710152_252415487.0RegionNote=Coil 1B
TgeneKRT86chr12:30837235chr12:52702017ENST000005440247101_106415487.0RegionNote=Head
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710253_269415487.0RegionNote=Linker 12
TgeneKRT86chr12:30837235chr12:52702017ENST00000544024710270_413415487.0RegionNote=Coil 2


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Fusion Gene Sequence for IPO8-KRT86


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40074_40074_1_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000293525_length(transcript)=1454nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT
CTGTAGCCTTTCCTGGTAGTCAATTTGTTGTCCCGAGGATTCATCTTTTTCTTCCGCCTGCCTTCTGTTTTTTTTGCTGTATACATTGGT
CTTGCCTGAGCTCTTCCCCAAAGCTTGGAGGAACGGGGGAGGCCCGGGAATGTCCCTGTCTGCACGACCTGGGACTCTGCCCATGTGCTT
TTGCCTGTGGAATGGAGACGCGGACCCTGGATAGTGGTTCTATGACTCTGCGAGGGACAGGCCCACGCGTGTGGGGAGAACATCTCCCTT
CCGGGGCTGCCCTCAAGAGCTTCTGAAAAACTAATGACTCTGCTGCCTTCTCCTTTGTCTTTGTTTCACTCTGTGTTTCCAATAAACTCA

>40074_40074_1_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000293525_length(amino acids)=199AA_BP=0
MGRVPGRADRDIPGPPPFLQALGKSSGKTNVYSKKNRRQAEEKDESSGQQIDYQERLQRETMAPPGPPRTPATGDGSRSGAVGRALRVQA
AGGGYWEAGAGGAFWWREVLAGWRVTATGAGGGGSLLAPLTAAAADANPGGGGAGVSSAHHHVAVAGDATDSGGDNRGSSGGAEIATDNA

--------------------------------------------------------------
>40074_40074_2_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000423955_length(transcript)=1105nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT

>40074_40074_2_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000423955_length(amino acids)=178AA_BP=94
MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQ

--------------------------------------------------------------
>40074_40074_3_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000544024_length(transcript)=1174nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT
CTGTAGCCTTTCCTGGTAGTCAATTTGTTGTCCCGAGGATTCATCTTTTTCTTCCGCCTGCCTTCTGTTTTTTTTGCTGTATACATTGGT

>40074_40074_3_IPO8-KRT86_IPO8_chr12_30837234_ENST00000256079_KRT86_chr12_52702016_ENST00000544024_length(amino acids)=178AA_BP=94
MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQ

--------------------------------------------------------------
>40074_40074_4_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000293525_length(transcript)=1454nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT
CTGTAGCCTTTCCTGGTAGTCAATTTGTTGTCCCGAGGATTCATCTTTTTCTTCCGCCTGCCTTCTGTTTTTTTTGCTGTATACATTGGT
CTTGCCTGAGCTCTTCCCCAAAGCTTGGAGGAACGGGGGAGGCCCGGGAATGTCCCTGTCTGCACGACCTGGGACTCTGCCCATGTGCTT
TTGCCTGTGGAATGGAGACGCGGACCCTGGATAGTGGTTCTATGACTCTGCGAGGGACAGGCCCACGCGTGTGGGGAGAACATCTCCCTT
CCGGGGCTGCCCTCAAGAGCTTCTGAAAAACTAATGACTCTGCTGCCTTCTCCTTTGTCTTTGTTTCACTCTGTGTTTCCAATAAACTCA

>40074_40074_4_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000293525_length(amino acids)=199AA_BP=0
MGRVPGRADRDIPGPPPFLQALGKSSGKTNVYSKKNRRQAEEKDESSGQQIDYQERLQRETMAPPGPPRTPATGDGSRSGAVGRALRVQA
AGGGYWEAGAGGAFWWREVLAGWRVTATGAGGGGSLLAPLTAAAADANPGGGGAGVSSAHHHVAVAGDATDSGGDNRGSSGGAEIATDNA

--------------------------------------------------------------
>40074_40074_5_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000423955_length(transcript)=1105nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT

>40074_40074_5_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000423955_length(amino acids)=178AA_BP=94
MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQ

--------------------------------------------------------------
>40074_40074_6_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000544024_length(transcript)=1174nt_BP=662nt
ACAGCAGCATGGCGGCCGCCGACGGGAGGCGGTCATAGCATCACGCCCGGGGGAAGAGGCCGCCGTAAAGGAAGCTCTGCTTCCTCTTCT
TCCTTCTCCCGCCTCCCACCGGCTGTCGTAAAACGGTGAATGGAGAGCGAGTTGTGGGGGGGAAAAAGGGAGGACAGGGGGCGCGGAGTC
AGAGTGGCGCAGCAAGTGGCCGCAGGTGGCGACGGTGGCGGGGGGTGGGGTGTGAGGTAATCCAGGGGTCGCGGAAGAGGAGGCTGAGAG
GGTCAAAAGAAAACTAAAGCTGCAGTCCGGCCTACTGTTCCGGGGGCCGCGGAGCCCCCACCCGGGGAGATGGACCTCAACCGGATCATC
CAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATTGCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCC
AGTTTACTTCGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTGAAGAACATGGTGACACAATAC
TGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTTCCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTG
GAAGGAATAATTCGGTCTCCAGATTTAGTGAGGCTGTGCGAGGGCGTCGGCTCGGTGAATGTCTGCGTCAGCAGCTCCCGCGGTGGCGTT
GTCTGTGGCGATCTCTGCGCCTCCACTACTGCCCCTGTTGTCTCCACCAGAGTCAGTAGCGTCCCCAGCAACAGCAACGTGGTGGTGGGC
ACTACTAACGCCTGCGCCCCCTCCGCCCGGGTTGGCGTCTGCGGCGGCAGCTGTAAGAGGTGCTAGGAGGCTGCCGCCTCCGCCAGCGCC
TGTCGCCGTCACTCTCCACCCAGCCAGTACCTCGCGCCACCAGAACGCGCCGCCCGCGCCGGCCTCCCAATAGCCGCCGCCCGCTGCCTG
CACTCTAAGCGCCCTCCCCACCGCTCCGCTCCGGGAGCCATCCCCGGTCGCAGGAGTCCGGGGAGGGCCGGGAGGCGCCATGGTCTCTCT
CTGTAGCCTTTCCTGGTAGTCAATTTGTTGTCCCGAGGATTCATCTTTTTCTTCCGCCTGCCTTCTGTTTTTTTTGCTGTATACATTGGT

>40074_40074_6_IPO8-KRT86_IPO8_chr12_30837235_ENST00000256079_KRT86_chr12_52702017_ENST00000544024_length(amino acids)=178AA_BP=94
MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IPO8-KRT86


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPO8-KRT86


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPO8-KRT86


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource