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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPPK-IARS (FusionGDB2 ID:40088)

Fusion Gene Summary for IPPK-IARS

check button Fusion gene summary
Fusion gene informationFusion gene name: IPPK-IARS
Fusion gene ID: 40088
HgeneTgene
Gene symbol

IPPK

IARS

Gene ID

64768

3376

Gene nameinositol-pentakisphosphate 2-kinaseisoleucyl-tRNA synthetase 1
SynonymsC9orf12|INSP5K2|IP5K|IPK1|bA476B13.1GRIDHH|IARS|ILERS|ILRS|IRS|PRO0785
Cytomap

9q22.31

9q22.31

Type of geneprotein-codingprotein-coding
Descriptioninositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinaseisoleucine--tRNA ligase, cytoplasmicisoleucine tRNA ligase 1, cytoplasmic
Modification date2020031320200313
UniProtAcc

Q9H8X2

Q9NSE4

Ensembl transtripts involved in fusion geneENST00000287996, ENST00000375522, 
ENST00000486841, 		ENST00000375629, 
ENST00000443024, ENST00000447699, 
ENST00000375627, ENST00000474340, 
ENST00000375643, 
Fusion gene scores* DoF score9 X 7 X 9=5677 X 10 X 5=350
# samples 1311
** MAII scorelog2(13/567*10)=-2.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/350*10)=-1.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPPK [Title/Abstract] AND IARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIPPK(95432190)-IARS(95019082), # samples:2
IPPK(95396668)-IARS(94973171), # samples:2
Anticipated loss of major functional domain due to fusion event.IPPK-IARS seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IPPK-IARS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIPPK

GO:0052746

inositol phosphorylation

12084730

TgeneIARS

GO:0006428

isoleucyl-tRNA aminoacylation

8052601


check buttonFusion gene breakpoints across IPPK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-RS-A6TO-01AIPPKchr9

95432190

-IARSchr9

95019082

-
ChimerDB4HNSCTCGA-RS-A6TOIPPKchr9

95432190

-IARSchr9

95019082

-
ChimerDB4OVTCGA-29-1691-01AIPPKchr9

95396668

-IARSchr9

94973171

-
ChimerDB4OVTCGA-29-1691IPPKchr9

95396667

-IARSchr9

94973171

-


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Fusion Gene ORF analysis for IPPK-IARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287996ENST00000375629IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000287996ENST00000375629IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-3UTRENST00000287996ENST00000443024IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000287996ENST00000443024IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-3UTRENST00000287996ENST00000447699IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000287996ENST00000447699IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000375629IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000375629IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000443024IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000443024IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000447699IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-3UTRENST00000375522ENST00000447699IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-5UTRENST00000287996ENST00000375629IPPKchr9

95432190

-IARSchr9

95019082

-
5CDS-5UTRENST00000287996ENST00000443024IPPKchr9

95432190

-IARSchr9

95019082

-
5CDS-5UTRENST00000287996ENST00000447699IPPKchr9

95432190

-IARSchr9

95019082

-
5CDS-intronENST00000287996ENST00000375627IPPKchr9

95432190

-IARSchr9

95019082

-
5CDS-intronENST00000287996ENST00000375627IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-intronENST00000287996ENST00000375627IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-intronENST00000287996ENST00000474340IPPKchr9

95432190

-IARSchr9

95019082

-
5CDS-intronENST00000287996ENST00000474340IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-intronENST00000287996ENST00000474340IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-intronENST00000375522ENST00000375627IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-intronENST00000375522ENST00000375627IPPKchr9

95396667

-IARSchr9

94973171

-
5CDS-intronENST00000375522ENST00000474340IPPKchr9

95396668

-IARSchr9

94973171

-
5CDS-intronENST00000375522ENST00000474340IPPKchr9

95396667

-IARSchr9

94973171

-
Frame-shiftENST00000287996ENST00000375643IPPKchr9

95396668

-IARSchr9

94973171

-
Frame-shiftENST00000287996ENST00000375643IPPKchr9

95396667

-IARSchr9

94973171

-
Frame-shiftENST00000375522ENST00000375643IPPKchr9

95396668

-IARSchr9

94973171

-
Frame-shiftENST00000375522ENST00000375643IPPKchr9

95396667

-IARSchr9

94973171

-
In-frameENST00000287996ENST00000375643IPPKchr9

95432190

-IARSchr9

95019082

-
intron-3CDSENST00000375522ENST00000375643IPPKchr9

95432190

-IARSchr9

95019082

-
intron-3CDSENST00000486841ENST00000375643IPPKchr9

95432190

-IARSchr9

95019082

-
intron-3CDSENST00000486841ENST00000375643IPPKchr9

95396668

-IARSchr9

94973171

-
intron-3CDSENST00000486841ENST00000375643IPPKchr9

95396667

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000375629IPPKchr9

95396668

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000375629IPPKchr9

95396667

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000443024IPPKchr9

95396668

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000443024IPPKchr9

95396667

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000447699IPPKchr9

95396668

-IARSchr9

94973171

-
intron-3UTRENST00000486841ENST00000447699IPPKchr9

95396667

-IARSchr9

94973171

-
intron-5UTRENST00000375522ENST00000375629IPPKchr9

95432190

-IARSchr9

95019082

-
intron-5UTRENST00000375522ENST00000443024IPPKchr9

95432190

-IARSchr9

95019082

-
intron-5UTRENST00000375522ENST00000447699IPPKchr9

95432190

-IARSchr9

95019082

-
intron-5UTRENST00000486841ENST00000375629IPPKchr9

95432190

-IARSchr9

95019082

-
intron-5UTRENST00000486841ENST00000443024IPPKchr9

95432190

-IARSchr9

95019082

-
intron-5UTRENST00000486841ENST00000447699IPPKchr9

95432190

-IARSchr9

95019082

-
intron-intronENST00000375522ENST00000375627IPPKchr9

95432190

-IARSchr9

95019082

-
intron-intronENST00000375522ENST00000474340IPPKchr9

95432190

-IARSchr9

95019082

-
intron-intronENST00000486841ENST00000375627IPPKchr9

95432190

-IARSchr9

95019082

-
intron-intronENST00000486841ENST00000375627IPPKchr9

95396668

-IARSchr9

94973171

-
intron-intronENST00000486841ENST00000375627IPPKchr9

95396667

-IARSchr9

94973171

-
intron-intronENST00000486841ENST00000474340IPPKchr9

95432190

-IARSchr9

95019082

-
intron-intronENST00000486841ENST00000474340IPPKchr9

95396668

-IARSchr9

94973171

-
intron-intronENST00000486841ENST00000474340IPPKchr9

95396667

-IARSchr9

94973171

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287996IPPKchr995432190-ENST00000375643IARSchr995019082-27313582652130621

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287996ENST00000375643IPPKchr995432190-IARSchr995019082-0.0007444830.9992555

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Fusion Genomic Features for IPPK-IARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IPPK-IARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:95432190/chr9:95019082)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPPK

Q9H8X2

IARS

Q9NSE4

FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPPKchr9:95432190chr9:95019082ENST00000287996-113136_14027492.0MotifNote=EXKPK motif
TgeneIARSchr9:95432190chr9:95019082ENST00000375643183448_586721263.0MotifNote='HIGH' region
TgeneIARSchr9:95432190chr9:95019082ENST000003756431834600_6046721263.0MotifNote='KMSKS' region
TgeneIARSchr9:95432190chr9:95019082ENST00000443024183448_586721263.0MotifNote='HIGH' region
TgeneIARSchr9:95432190chr9:95019082ENST000004430241834600_6046721263.0MotifNote='KMSKS' region


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Fusion Gene Sequence for IPPK-IARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40088_40088_1_IPPK-IARS_IPPK_chr9_95432190_ENST00000287996_IARS_chr9_95019082_ENST00000375643_length(transcript)=2731nt_BP=358nt
TCTACCAGTACCTAAGATGGCCGCCGGCCCATCCACCGTCGCGATCGGTGTGAGGAAAGTGTCACGAACCCGGAATTGCCCGACTCCGTC
ATGGCAGGCGCCGGGGGCGTGGCTTCCGGCGGCCACAGCTTGCTAGTCGCCGCGGCGGGGTCGAGCGGGGGCGGCAGCTGACAGGCGCTC
CTCCCCCGACCGCAGCGGCTGGTTCCCAGCGAGGCGGGCGGCCCCCAGCTCGCGTCCCCGAGTCCTAGCCCGCGAGGCGCCAGGGCTGCG
CCTGGGCATGGAAGAGGGGAAGATGGACGAGAATGAATGGGGGTACCACGGAGAGGGCAATAAGAGCCTGGTGGTGGCCCACGCGCAGGA
GGAAGAAATAGAATTTCTCTACAATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATCCTGTCCTTCATGCAGTCTCT
CATTGGCTTCTTTGAGACTGAAATGGCAGCTTATAGGCTTTATACTGTGGTGCCTCGCCTGGTCAAGTTTGTAGATATTCTGACCAATTG
GTATGTTAGAATGAACCGCAGAAGATTAAAGGGTGAAAATGGGATGGAGGATTGTGTCATGGCCCTAGAAACCTTGTTTAGTGTTCTGCT
TTCTCTTTGCAGACTTATGGCTCCCTACACACCTTTTCTCACTGAATTGATGTACCAGAATCTAAAGGTGCTGATTGACCCTGTTTCTGT
TCAGGACAAGGACACACTCAGCATTCACTACCTCATGCTGCCCCGTGTTCGAGAAGAATTGATTGACAAGAAAACAGAGAGTGCAGTATC
TCAGATGCAGTCTGTGATTGAACTTGGAAGAGTGATCAGAGACCGAAAAACTATTCCCATAAAGTATCCTTTGAAAGAAATTGTGGTTAT
CCATCAAGATCCAGAAGCTCTTAAAGATATCAAGTCTTTGGAGAAGTATATCATTGAGGAACTCAATGTTCGAAAAGTTACACTGTCTAC
AGATAAAAACAAGTATGGCATTCGGCTAAGGGCAGAACCAGATCACATGGTCCTGGGGAAGCGTCTGAAGGGAGCCTTTAAGGCAGTGAT
GACGTCCATCAAGCAGTTGAGCAGTGAGGAGCTGGAGCAGTTCCAGAAGACTGGGACCATTGTTGTGGAAGGCCATGAATTGCACGATGA
AGACATCCGCCTCATGTACACCTTTGATCAGGCCACAGGTGGGACTGCGCAATTTGAAGCACACTCAGATGCTCAGGCTTTGGTCCTCTT
AGATGTCACTCCTGACCAGTCAATGGTAGATGAAGGAATGGCTCGGGAAGTCATCAATCGCATACAGAAACTTCGCAAAAAGTGCAATCT
GGTTCCAACTGATGAAATCACAGTGTACTATAAAGCAAAGTCTGAAGGAACATATCTGAATAGTGTTATTGAAAGCCACACAGAGTTCAT
ATTTACCACCATAAAGGCTCCCTTGAAACCATATCCAGTTTCTCCATCGGATAAAGTCCTTATTCAAGAAAAAACACAGTTGAAGGGATC
TGAACTGGAAATTACACTCACCAGAGGATCTTCCCTTCCTGGTCCTGCTTGTGCATATGTCAATCTTAACATTTGTGCAAATGGCAGTGA
ACAAGGTGGAGTATTGCTCCTGGAAAATCCAAAAGGTGACAATAGGTTGGACCTTTTAAAGCTGAAGAGTGTTGTCACTAGCATTTTTGG
TGTGAAAAATACAGAGCTGGCTGTCTTCCATGATGAAACAGAAATACAAAACCAAACTGACTTACTGAGTCTTAGTGGAAAAACACTTTG
TGTGACTGCAGGATCGGCTCCCTCTCTGATCAACAGTTCTAGTACTCTTCTTTGTCAGTATATCAACCTACAGCTCCTGAATGCAAAGCC
ACAAGAGTGTTTAATGGGGACAGTGGGCACTCTCCTGCTTGAAAACCCACTTGGGCAGAATGGACTCACCCACCAAGGTCTTCTGTATGA
AGCAGCCAAGGTGTTTGGCCTTCGGAGCAGGAAGCTAAAGCTGTTTCTGAATGAGACCCAAACGCAGGAAATTACAGAAGACATCCCCGT
GAAGACTTTGAATATGAAGACTGTGTATGTTTCTGTGTTACCAACAACAGCAGACTTCTAGCATGTACTTATCAATGTTGTTCGGTCAGC
CCTTCCCTAATTACACCTATCCCCTACACATACATGCACATAGACACACACATGAACACACTGAAGATATTTCCTTCAGGTGTGTGTAAA
ATATGCTGCTTGGATTGAAATTCAAATGGGATTGATTAGTCAAGTAACTTGAGACCTCACAGTAATCTTCACACTTAACCTTAGACACCT
ATGCAGTCATGTTGGGAGCAGGTTACAATGTTACTTCAGCCCACAGTTTATTTCTATACTTGAGTTCTTAAGTACAGAAGATAGAAGTGA
TTTAAATGGCATAGTATATATATCATTTTCTGGCCTTTTAAAATTTATTTGAGACCTCTTGATGAAATGGACATATTATATATTTCTGCC
ACCTGGATTTTCCTGGATAATTTGATGGAATATTTTAAGTTTCAGTAAATCAGAACAATAAACAAACTCAGATATAAATGTGTTGAAAGT
AATTCATTCTCCCATAGATAAATGAAACTTGAAATGTGTAAACTTTGAAGAACATAAAAACTTCATGGTGGTTTCTTATTAAGACAGTGG

>40088_40088_1_IPPK-IARS_IPPK_chr9_95432190_ENST00000287996_IARS_chr9_95019082_ENST00000375643_length(amino acids)=621AA_BP=1
MRLGMEEGKMDENEWGYHGEGNKSLVVAHAQEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILT
NWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESA
VSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKA
VMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKC
NLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANG
SEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IPPK-IARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPPK-IARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPPK-IARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource