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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPPK-ZNF484 (FusionGDB2 ID:40092)

Fusion Gene Summary for IPPK-ZNF484

check button Fusion gene summary
Fusion gene informationFusion gene name: IPPK-ZNF484
Fusion gene ID: 40092
HgeneTgene
Gene symbol

IPPK

ZNF484

Gene ID

64768

83744

Gene nameinositol-pentakisphosphate 2-kinasezinc finger protein 484
SynonymsC9orf12|INSP5K2|IP5K|IPK1|bA476B13.1BA526D8.4
Cytomap

9q22.31

9q22.31

Type of geneprotein-codingprotein-coding
Descriptioninositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinasezinc finger protein 484KRAB box containing C2H2 type zinc finger bA526D8.4
Modification date2020031320200313
UniProtAcc

Q9H8X2

.
Ensembl transtripts involved in fusion geneENST00000287996, ENST00000375522, 
ENST00000486841, 		ENST00000332591, 
ENST00000375495, ENST00000395505, 
ENST00000395506, 
Fusion gene scores* DoF score9 X 7 X 9=5674 X 3 X 3=36
# samples 134
** MAII scorelog2(13/567*10)=-2.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IPPK [Title/Abstract] AND ZNF484 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIPPK(95432190)-ZNF484(95618600), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIPPK

GO:0052746

inositol phosphorylation

12084730


check buttonFusion gene breakpoints across IPPK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF484 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8361-01AIPPKchr9

95432190

-ZNF484chr9

95618600

-


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Fusion Gene ORF analysis for IPPK-ZNF484

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000287996ENST00000332591IPPKchr9

95432190

-ZNF484chr9

95618600

-
In-frameENST00000287996ENST00000375495IPPKchr9

95432190

-ZNF484chr9

95618600

-
In-frameENST00000287996ENST00000395505IPPKchr9

95432190

-ZNF484chr9

95618600

-
In-frameENST00000287996ENST00000395506IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000375522ENST00000375495IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000375522ENST00000395505IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000375522ENST00000395506IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000486841ENST00000375495IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000486841ENST00000395505IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-3CDSENST00000486841ENST00000395506IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-5UTRENST00000375522ENST00000332591IPPKchr9

95432190

-ZNF484chr9

95618600

-
intron-5UTRENST00000486841ENST00000332591IPPKchr9

95432190

-ZNF484chr9

95618600

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287996IPPKchr995432190-ENST00000395505ZNF484chr995618600-35383582652901878
ENST00000287996IPPKchr995432190-ENST00000395506ZNF484chr995618600-30883582652901878
ENST00000287996IPPKchr995432190-ENST00000375495ZNF484chr995618600-30613582652901878

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287996ENST00000395505IPPKchr995432190-ZNF484chr995618600-0.0003812660.99961865
ENST00000287996ENST00000395506IPPKchr995432190-ZNF484chr995618600-0.0004179780.999582
ENST00000287996ENST00000375495IPPKchr995432190-ZNF484chr995618600-0.0004441660.99955577

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Fusion Genomic Features for IPPK-ZNF484


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IPPK-ZNF484


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:95432190/chr9:95618600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPPK

Q9H8X2

.
FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF484chr9:95432190chr9:95618600ENST00000332591048_780817.0DomainKRAB
TgeneZNF484chr9:95432190chr9:95618600ENST00000375495158_785853.0DomainKRAB
TgeneZNF484chr9:95432190chr9:95618600ENST00000395506048_787855.0DomainKRAB
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104223_2450817.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104279_3010817.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104328_3500817.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104356_3780817.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104384_4060817.0Zinc fingerC2H2-type 5
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104412_4340817.0Zinc fingerC2H2-type 6
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104440_4620817.0Zinc fingerC2H2-type 7
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104468_4900817.0Zinc fingerC2H2-type 8
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104496_5180817.0Zinc fingerC2H2-type 9
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104524_5460817.0Zinc fingerC2H2-type 10
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104552_5740817.0Zinc fingerC2H2-type 11
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104580_6020817.0Zinc fingerC2H2-type 12
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104608_6300817.0Zinc fingerC2H2-type 13
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104636_6580817.0Zinc fingerC2H2-type 14
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104664_6860817.0Zinc fingerC2H2-type 15
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104692_7140817.0Zinc fingerC2H2-type 16
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104720_7420817.0Zinc fingerC2H2-type 17
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104748_7700817.0Zinc fingerC2H2-type 18
TgeneZNF484chr9:95432190chr9:95618600ENST0000033259104776_7980817.0Zinc fingerC2H2-type 19
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515223_2455853.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515279_3015853.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515328_3505853.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515356_3785853.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515384_4065853.0Zinc fingerC2H2-type 5
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515412_4345853.0Zinc fingerC2H2-type 6
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515440_4625853.0Zinc fingerC2H2-type 7
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515468_4905853.0Zinc fingerC2H2-type 8
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515496_5185853.0Zinc fingerC2H2-type 9
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515524_5465853.0Zinc fingerC2H2-type 10
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515552_5745853.0Zinc fingerC2H2-type 11
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515580_6025853.0Zinc fingerC2H2-type 12
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515608_6305853.0Zinc fingerC2H2-type 13
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515636_6585853.0Zinc fingerC2H2-type 14
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515664_6865853.0Zinc fingerC2H2-type 15
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515692_7145853.0Zinc fingerC2H2-type 16
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515720_7425853.0Zinc fingerC2H2-type 17
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515748_7705853.0Zinc fingerC2H2-type 18
TgeneZNF484chr9:95432190chr9:95618600ENST0000037549515776_7985853.0Zinc fingerC2H2-type 19
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13223_24511817.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13279_30111817.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13328_35011817.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13356_37811817.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13384_40611817.0Zinc fingerC2H2-type 5
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13412_43411817.0Zinc fingerC2H2-type 6
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13440_46211817.0Zinc fingerC2H2-type 7
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13468_49011817.0Zinc fingerC2H2-type 8
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13496_51811817.0Zinc fingerC2H2-type 9
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13524_54611817.0Zinc fingerC2H2-type 10
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13552_57411817.0Zinc fingerC2H2-type 11
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13580_60211817.0Zinc fingerC2H2-type 12
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13608_63011817.0Zinc fingerC2H2-type 13
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13636_65811817.0Zinc fingerC2H2-type 14
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13664_68611817.0Zinc fingerC2H2-type 15
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13692_71411817.0Zinc fingerC2H2-type 16
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13720_74211817.0Zinc fingerC2H2-type 17
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13748_77011817.0Zinc fingerC2H2-type 18
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-13776_79811817.0Zinc fingerC2H2-type 19
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604223_2457855.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604279_3017855.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604328_3507855.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604356_3787855.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604384_4067855.0Zinc fingerC2H2-type 5
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604412_4347855.0Zinc fingerC2H2-type 6
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604440_4627855.0Zinc fingerC2H2-type 7
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604468_4907855.0Zinc fingerC2H2-type 8
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604496_5187855.0Zinc fingerC2H2-type 9
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604524_5467855.0Zinc fingerC2H2-type 10
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604552_5747855.0Zinc fingerC2H2-type 11
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604580_6027855.0Zinc fingerC2H2-type 12
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604608_6307855.0Zinc fingerC2H2-type 13
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604636_6587855.0Zinc fingerC2H2-type 14
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604664_6867855.0Zinc fingerC2H2-type 15
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604692_7147855.0Zinc fingerC2H2-type 16
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604720_7427855.0Zinc fingerC2H2-type 17
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604748_7707855.0Zinc fingerC2H2-type 18
TgeneZNF484chr9:95432190chr9:95618600ENST0000039550604776_7987855.0Zinc fingerC2H2-type 19

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPPKchr9:95432190chr9:95618600ENST00000287996-113136_14027492.0MotifNote=EXKPK motif
TgeneZNF484chr9:95432190chr9:95618600ENST00000395505-138_7811817.0DomainKRAB


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Fusion Gene Sequence for IPPK-ZNF484


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40092_40092_1_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000375495_length(transcript)=3061nt_BP=358nt
TCTACCAGTACCTAAGATGGCCGCCGGCCCATCCACCGTCGCGATCGGTGTGAGGAAAGTGTCACGAACCCGGAATTGCCCGACTCCGTC
ATGGCAGGCGCCGGGGGCGTGGCTTCCGGCGGCCACAGCTTGCTAGTCGCCGCGGCGGGGTCGAGCGGGGGCGGCAGCTGACAGGCGCTC
CTCCCCCGACCGCAGCGGCTGGTTCCCAGCGAGGCGGGCGGCCCCCAGCTCGCGTCCCCGAGTCCTAGCCCGCGAGGCGCCAGGGCTGCG
CCTGGGCATGGAAGAGGGGAAGATGGACGAGAATGAATGGGGGTACCACGGAGAGGGCAATAAGAGCCTGGTGGTGGCCCACGCGCAGGA
ATCAGTGTCATTCAAGGACGTAACTGTAGACTTCAGTAGGGATGAGTGGCAACAATTAGACCTTGCTCAGAAAAGCCTGTACAGAGAAGT
GATGCTGGAAAACTATTTCAACTTGATCTCAGTGGGATGTCAAGTTCCCAAACCAGAAGTCATCTTCAGCTTGGAACAAGAAGAGCCATG
TATGTTGGATGGTGAGATCCCCAGTCAGAGCCGTCCAGATGGGGACATTGGTTTTGGACCTTTACAACAGAGGATGTCTGAAGAAGTTTC
TTTCCAGTCTGAGATTAATATTAATCTCTTCACAAGAGATGACCCATATTCCATTTTAGAAGAATTGTGGAAAGACGATGAACACACAAG
AAAATGTGGAGAAAACCAGAACAAACCTTTAAGTCGTGTTGTCTTCATTAACAAGAAAACACTAGCTAATGACAGCATCTTTGAATATAA
GGACATTGGGGAAATAGTTCATGTAAACACACACCTGGTTTCCTCAAGAAAAAGACCCCATAACTGTAACTCGTGTGGAAAGAATTTGGA
GCCTATCATAACCTTATATAATAGAAACAATGCAACAGAAAATTCTGATAAGACTATTGGAGATGGTGATATTTTCACTCATTTGAATTC
TCATACAGAAGTGACTGCTTGTGAATGTAACCAATGTGGGAAACCTCTGCATCATAAGCAAGCTCTCATTCAACAACAGAAAATTCATAC
TAGAGAGAGCCTCTATTTGTTTTCTGACTACGTAAATGTTTTCTCCCCGAAGTCACATGCCTTTGCACATGAGAGTATTTGTGCTGAAGA
AAAGCAGCATGAATGCCATGAATGTGAGGCAGTCTTCACTCAGAAGTCCCAGCTTGATGGCAGTCAGAGGGTTTATGCAGGAATATGCAC
TGAATATGAGAAGGATTTTTCCCTCAAGTCAAACCGTCAGAAAACTCCTTATGAGGGGAATTACTATAAATGCAGTGACTATGGAAGAGC
CTTTATCCAGAAGTCAGATCTGTTCAGATGCCAGAGAATTCATTCTGGAGAAAAACCTTATGAGTACAGTGAATGTGAGAAAAACCTCCC
TCAGAATTCAAACCTTAATATACATAAAAAAATTCATACTGGAGGGAAACACTTTGAATGTACTGAATGTGGAAAAGCTTTCACAAGGAA
ATCAACACTAAGTATGCATCAGAAAATCCATACAGGAGAAAAACCTTATGTATGTACTGAATGTGGGAAGGCCTTTATCCGGAAGTCACA
TTTTATCACACATGAAAGAATTCATACTGGAGAAAAACCCTATGAATGCAGTGACTGTGGGAAATCCTTTATTAAAAAATCACAACTCCA
TGTGCATCAGCGAATTCACACAGGAGAGAATCCCTTTATATGTTCAGAATGTGGGAAGGTCTTCACTCACAAGACAAATCTCATTATACA
CCAGAAAATTCATACAGGAGAAAGACCCTATATATGTACTGTGTGTGGTAAGGCCTTTACTGACAGGTCAAATCTCATTAAGCACCAAAA
AATTCATACTGGAGAGAAACCTTATAAATGCAGCGACTGTGGAAAATCATTCACCTGGAAGTCTCGGCTCAGGATACATCAGAAGTGTCA
TACTGGAGAGAGACATTATGAATGCAGTGAATGTGGGAAAGCATTCATTCAGAAGTCAACATTAAGTATGCACCAGAGAATTCATAGAGG
GGAAAAACCATATGTTTGCACTGAATGTGGTAAGGCCTTCTTCCACAAATCCCATTTTATTACACATGAGAGAATTCATACTGGAGAGAA
ACCCTATGAATGCAGTATTTGTGGGAAATCCTTCACTAAGAAATCACAGCTCCACGTACATCAGCAGATTCACACAGGAGAGAAACCCTA
TAGGTGTGCTGAATGTGGAAAGGCTTTTACTGACAGATCAAATCTCTTTACACACCAGAAAATTCACACTGGAGAGAAACCTTATAAATG
TAGTGACTGTGGGAAAGCCTTCACTAGGAAGTCAGGTCTCCATATACATCAGCAATCCCATACTGGAGAAAGGCATTATGAGTGCAGTGA
ATGTGGGAAAGCCTTTGCAAGAAAATCAACACTAATTATGCATCAGAGAATTCATACAGGAGAGAAACCCTATATTTGTAATGAATGTGG
GAAATCCTTCATCCAGAAGTCACACTTAAATAGACACAGGAGAATTCATACTGGAGAGAAACCCTATGAATGCAGTGACTGTGGCAAGTC
TTTCATTAAGAAATCACAACTCCATGAGCATCATCGAATTCACACAGGAGAGAAACCATATATATGTGCTGAGTGTGGAAAGGCCTTCAC
CATCAGATCAAATCTTATTAAACACCAGAAAATTCATACTAAACAGAAACCCTATAAGTGCAGTGACTTGGGGAAAGCCTTAAACTGGAA
GCCACAACTCAGTATGCCTCAGAAATCTGACAATGGGGAAGTAGAGTGCTCCATGCCACAATTATGGTGTGGGGACTCAGAAGGTGACCA
AGGCCAACTTTCTTCTATCTAGTTAGAATTATGAACATCTGGATCATATAGCTGATGTGTAGTTACACATATGGGGAGACACTTTTGAGA
GTGTTTAAGCAATGTATAGTGGCCATCTTTGGTTACTTGATATTGGTGTTGTCAAGCTCCTGCAAATAATAGTAAATGTGCAAGGAGATG

>40092_40092_1_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000375495_length(amino acids)=878AA_BP=30
MRLGMEEGKMDENEWGYHGEGNKSLVVAHAQESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNLISVGCQVPKPEVIFSLEQEE
PCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEININLFTRDDPYSILEELWKDDEHTRKCGENQNKPLSRVVFINKKTLANDSIFE
YKDIGEIVHVNTHLVSSRKRPHNCNSCGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHTEVTACECNQCGKPLHHKQALIQQQKI
HTRESLYLFSDYVNVFSPKSHAFAHESICAEEKQHECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYG
RAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTGEKPYVCTECGKAFIRK
SHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKH
QKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHTG
EKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQSHTGERHYEC
SECGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNRHRRIHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKA

--------------------------------------------------------------
>40092_40092_2_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000395505_length(transcript)=3538nt_BP=358nt
TCTACCAGTACCTAAGATGGCCGCCGGCCCATCCACCGTCGCGATCGGTGTGAGGAAAGTGTCACGAACCCGGAATTGCCCGACTCCGTC
ATGGCAGGCGCCGGGGGCGTGGCTTCCGGCGGCCACAGCTTGCTAGTCGCCGCGGCGGGGTCGAGCGGGGGCGGCAGCTGACAGGCGCTC
CTCCCCCGACCGCAGCGGCTGGTTCCCAGCGAGGCGGGCGGCCCCCAGCTCGCGTCCCCGAGTCCTAGCCCGCGAGGCGCCAGGGCTGCG
CCTGGGCATGGAAGAGGGGAAGATGGACGAGAATGAATGGGGGTACCACGGAGAGGGCAATAAGAGCCTGGTGGTGGCCCACGCGCAGGA
ATCAGTGTCATTCAAGGACGTAACTGTAGACTTCAGTAGGGATGAGTGGCAACAATTAGACCTTGCTCAGAAAAGCCTGTACAGAGAAGT
GATGCTGGAAAACTATTTCAACTTGATCTCAGTGGGATGTCAAGTTCCCAAACCAGAAGTCATCTTCAGCTTGGAACAAGAAGAGCCATG
TATGTTGGATGGTGAGATCCCCAGTCAGAGCCGTCCAGATGGGGACATTGGTTTTGGACCTTTACAACAGAGGATGTCTGAAGAAGTTTC
TTTCCAGTCTGAGATTAATATTAATCTCTTCACAAGAGATGACCCATATTCCATTTTAGAAGAATTGTGGAAAGACGATGAACACACAAG
AAAATGTGGAGAAAACCAGAACAAACCTTTAAGTCGTGTTGTCTTCATTAACAAGAAAACACTAGCTAATGACAGCATCTTTGAATATAA
GGACATTGGGGAAATAGTTCATGTAAACACACACCTGGTTTCCTCAAGAAAAAGACCCCATAACTGTAACTCGTGTGGAAAGAATTTGGA
GCCTATCATAACCTTATATAATAGAAACAATGCAACAGAAAATTCTGATAAGACTATTGGAGATGGTGATATTTTCACTCATTTGAATTC
TCATACAGAAGTGACTGCTTGTGAATGTAACCAATGTGGGAAACCTCTGCATCATAAGCAAGCTCTCATTCAACAACAGAAAATTCATAC
TAGAGAGAGCCTCTATTTGTTTTCTGACTACGTAAATGTTTTCTCCCCGAAGTCACATGCCTTTGCACATGAGAGTATTTGTGCTGAAGA
AAAGCAGCATGAATGCCATGAATGTGAGGCAGTCTTCACTCAGAAGTCCCAGCTTGATGGCAGTCAGAGGGTTTATGCAGGAATATGCAC
TGAATATGAGAAGGATTTTTCCCTCAAGTCAAACCGTCAGAAAACTCCTTATGAGGGGAATTACTATAAATGCAGTGACTATGGAAGAGC
CTTTATCCAGAAGTCAGATCTGTTCAGATGCCAGAGAATTCATTCTGGAGAAAAACCTTATGAGTACAGTGAATGTGAGAAAAACCTCCC
TCAGAATTCAAACCTTAATATACATAAAAAAATTCATACTGGAGGGAAACACTTTGAATGTACTGAATGTGGAAAAGCTTTCACAAGGAA
ATCAACACTAAGTATGCATCAGAAAATCCATACAGGAGAAAAACCTTATGTATGTACTGAATGTGGGAAGGCCTTTATCCGGAAGTCACA
TTTTATCACACATGAAAGAATTCATACTGGAGAAAAACCCTATGAATGCAGTGACTGTGGGAAATCCTTTATTAAAAAATCACAACTCCA
TGTGCATCAGCGAATTCACACAGGAGAGAATCCCTTTATATGTTCAGAATGTGGGAAGGTCTTCACTCACAAGACAAATCTCATTATACA
CCAGAAAATTCATACAGGAGAAAGACCCTATATATGTACTGTGTGTGGTAAGGCCTTTACTGACAGGTCAAATCTCATTAAGCACCAAAA
AATTCATACTGGAGAGAAACCTTATAAATGCAGCGACTGTGGAAAATCATTCACCTGGAAGTCTCGGCTCAGGATACATCAGAAGTGTCA
TACTGGAGAGAGACATTATGAATGCAGTGAATGTGGGAAAGCATTCATTCAGAAGTCAACATTAAGTATGCACCAGAGAATTCATAGAGG
GGAAAAACCATATGTTTGCACTGAATGTGGTAAGGCCTTCTTCCACAAATCCCATTTTATTACACATGAGAGAATTCATACTGGAGAGAA
ACCCTATGAATGCAGTATTTGTGGGAAATCCTTCACTAAGAAATCACAGCTCCACGTACATCAGCAGATTCACACAGGAGAGAAACCCTA
TAGGTGTGCTGAATGTGGAAAGGCTTTTACTGACAGATCAAATCTCTTTACACACCAGAAAATTCACACTGGAGAGAAACCTTATAAATG
TAGTGACTGTGGGAAAGCCTTCACTAGGAAGTCAGGTCTCCATATACATCAGCAATCCCATACTGGAGAAAGGCATTATGAGTGCAGTGA
ATGTGGGAAAGCCTTTGCAAGAAAATCAACACTAATTATGCATCAGAGAATTCATACAGGAGAGAAACCCTATATTTGTAATGAATGTGG
GAAATCCTTCATCCAGAAGTCACACTTAAATAGACACAGGAGAATTCATACTGGAGAGAAACCCTATGAATGCAGTGACTGTGGCAAGTC
TTTCATTAAGAAATCACAACTCCATGAGCATCATCGAATTCACACAGGAGAGAAACCATATATATGTGCTGAGTGTGGAAAGGCCTTCAC
CATCAGATCAAATCTTATTAAACACCAGAAAATTCATACTAAACAGAAACCCTATAAGTGCAGTGACTTGGGGAAAGCCTTAAACTGGAA
GCCACAACTCAGTATGCCTCAGAAATCTGACAATGGGGAAGTAGAGTGCTCCATGCCACAATTATGGTGTGGGGACTCAGAAGGTGACCA
AGGCCAACTTTCTTCTATCTAGTTAGAATTATGAACATCTGGATCATATAGCTGATGTGTAGTTACACATATGGGGAGACACTTTTGAGA
GTGTTTAAGCAATGTATAGTGGCCATCTTTGGTTACTTGATATTGGTGTTGTCAAGCTCCTGCAAATAATAGTAAATGTGCAAGGAGATG
ATTGGCAGTCTTTCTTGTTTCACTTTTTGGGCAAACAGTTTTATAAATTCATGGCTGTTGAGTTTTTCATGTTCTGGGTACCACAACTAT
TCAATATTGACCCGCAAAAATTCATAATGAGTAGTATGATGAGATAATTTTACATTGTCTAAGCAGCCTAAGGACACTGAGATCAAGGCA
AAGAGAGGGCAATTTAGGTCTATAATGAAAGTGAATCAGCAGTTTTTGTGAAAACACTAAAGACAGAAAGAAAGGACTCTACTTTTTTTA
AAATTTTCTTTGGGAAGTCACCATTATTTATTGTTATATCTGTTGGCGTATGCTGGGGCAGCAGTTAGCCAAGAGGTCTGAAATTGCTCT
TTGCCTATTTCTCAAAAGTCTATATTATTACCTTAGAACTGGCCCTACGATCATGGAACTTAGATACAGGGACCCAGGTCTAGATAGCAG

>40092_40092_2_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000395505_length(amino acids)=878AA_BP=30
MRLGMEEGKMDENEWGYHGEGNKSLVVAHAQESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNLISVGCQVPKPEVIFSLEQEE
PCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEININLFTRDDPYSILEELWKDDEHTRKCGENQNKPLSRVVFINKKTLANDSIFE
YKDIGEIVHVNTHLVSSRKRPHNCNSCGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHTEVTACECNQCGKPLHHKQALIQQQKI
HTRESLYLFSDYVNVFSPKSHAFAHESICAEEKQHECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYG
RAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTGEKPYVCTECGKAFIRK
SHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKH
QKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHTG
EKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQSHTGERHYEC
SECGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNRHRRIHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKA

--------------------------------------------------------------
>40092_40092_3_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000395506_length(transcript)=3088nt_BP=358nt
TCTACCAGTACCTAAGATGGCCGCCGGCCCATCCACCGTCGCGATCGGTGTGAGGAAAGTGTCACGAACCCGGAATTGCCCGACTCCGTC
ATGGCAGGCGCCGGGGGCGTGGCTTCCGGCGGCCACAGCTTGCTAGTCGCCGCGGCGGGGTCGAGCGGGGGCGGCAGCTGACAGGCGCTC
CTCCCCCGACCGCAGCGGCTGGTTCCCAGCGAGGCGGGCGGCCCCCAGCTCGCGTCCCCGAGTCCTAGCCCGCGAGGCGCCAGGGCTGCG
CCTGGGCATGGAAGAGGGGAAGATGGACGAGAATGAATGGGGGTACCACGGAGAGGGCAATAAGAGCCTGGTGGTGGCCCACGCGCAGGA
ATCAGTGTCATTCAAGGACGTAACTGTAGACTTCAGTAGGGATGAGTGGCAACAATTAGACCTTGCTCAGAAAAGCCTGTACAGAGAAGT
GATGCTGGAAAACTATTTCAACTTGATCTCAGTGGGATGTCAAGTTCCCAAACCAGAAGTCATCTTCAGCTTGGAACAAGAAGAGCCATG
TATGTTGGATGGTGAGATCCCCAGTCAGAGCCGTCCAGATGGGGACATTGGTTTTGGACCTTTACAACAGAGGATGTCTGAAGAAGTTTC
TTTCCAGTCTGAGATTAATATTAATCTCTTCACAAGAGATGACCCATATTCCATTTTAGAAGAATTGTGGAAAGACGATGAACACACAAG
AAAATGTGGAGAAAACCAGAACAAACCTTTAAGTCGTGTTGTCTTCATTAACAAGAAAACACTAGCTAATGACAGCATCTTTGAATATAA
GGACATTGGGGAAATAGTTCATGTAAACACACACCTGGTTTCCTCAAGAAAAAGACCCCATAACTGTAACTCGTGTGGAAAGAATTTGGA
GCCTATCATAACCTTATATAATAGAAACAATGCAACAGAAAATTCTGATAAGACTATTGGAGATGGTGATATTTTCACTCATTTGAATTC
TCATACAGAAGTGACTGCTTGTGAATGTAACCAATGTGGGAAACCTCTGCATCATAAGCAAGCTCTCATTCAACAACAGAAAATTCATAC
TAGAGAGAGCCTCTATTTGTTTTCTGACTACGTAAATGTTTTCTCCCCGAAGTCACATGCCTTTGCACATGAGAGTATTTGTGCTGAAGA
AAAGCAGCATGAATGCCATGAATGTGAGGCAGTCTTCACTCAGAAGTCCCAGCTTGATGGCAGTCAGAGGGTTTATGCAGGAATATGCAC
TGAATATGAGAAGGATTTTTCCCTCAAGTCAAACCGTCAGAAAACTCCTTATGAGGGGAATTACTATAAATGCAGTGACTATGGAAGAGC
CTTTATCCAGAAGTCAGATCTGTTCAGATGCCAGAGAATTCATTCTGGAGAAAAACCTTATGAGTACAGTGAATGTGAGAAAAACCTCCC
TCAGAATTCAAACCTTAATATACATAAAAAAATTCATACTGGAGGGAAACACTTTGAATGTACTGAATGTGGAAAAGCTTTCACAAGGAA
ATCAACACTAAGTATGCATCAGAAAATCCATACAGGAGAAAAACCTTATGTATGTACTGAATGTGGGAAGGCCTTTATCCGGAAGTCACA
TTTTATCACACATGAAAGAATTCATACTGGAGAAAAACCCTATGAATGCAGTGACTGTGGGAAATCCTTTATTAAAAAATCACAACTCCA
TGTGCATCAGCGAATTCACACAGGAGAGAATCCCTTTATATGTTCAGAATGTGGGAAGGTCTTCACTCACAAGACAAATCTCATTATACA
CCAGAAAATTCATACAGGAGAAAGACCCTATATATGTACTGTGTGTGGTAAGGCCTTTACTGACAGGTCAAATCTCATTAAGCACCAAAA
AATTCATACTGGAGAGAAACCTTATAAATGCAGCGACTGTGGAAAATCATTCACCTGGAAGTCTCGGCTCAGGATACATCAGAAGTGTCA
TACTGGAGAGAGACATTATGAATGCAGTGAATGTGGGAAAGCATTCATTCAGAAGTCAACATTAAGTATGCACCAGAGAATTCATAGAGG
GGAAAAACCATATGTTTGCACTGAATGTGGTAAGGCCTTCTTCCACAAATCCCATTTTATTACACATGAGAGAATTCATACTGGAGAGAA
ACCCTATGAATGCAGTATTTGTGGGAAATCCTTCACTAAGAAATCACAGCTCCACGTACATCAGCAGATTCACACAGGAGAGAAACCCTA
TAGGTGTGCTGAATGTGGAAAGGCTTTTACTGACAGATCAAATCTCTTTACACACCAGAAAATTCACACTGGAGAGAAACCTTATAAATG
TAGTGACTGTGGGAAAGCCTTCACTAGGAAGTCAGGTCTCCATATACATCAGCAATCCCATACTGGAGAAAGGCATTATGAGTGCAGTGA
ATGTGGGAAAGCCTTTGCAAGAAAATCAACACTAATTATGCATCAGAGAATTCATACAGGAGAGAAACCCTATATTTGTAATGAATGTGG
GAAATCCTTCATCCAGAAGTCACACTTAAATAGACACAGGAGAATTCATACTGGAGAGAAACCCTATGAATGCAGTGACTGTGGCAAGTC
TTTCATTAAGAAATCACAACTCCATGAGCATCATCGAATTCACACAGGAGAGAAACCATATATATGTGCTGAGTGTGGAAAGGCCTTCAC
CATCAGATCAAATCTTATTAAACACCAGAAAATTCATACTAAACAGAAACCCTATAAGTGCAGTGACTTGGGGAAAGCCTTAAACTGGAA
GCCACAACTCAGTATGCCTCAGAAATCTGACAATGGGGAAGTAGAGTGCTCCATGCCACAATTATGGTGTGGGGACTCAGAAGGTGACCA
AGGCCAACTTTCTTCTATCTAGTTAGAATTATGAACATCTGGATCATATAGCTGATGTGTAGTTACACATATGGGGAGACACTTTTGAGA
GTGTTTAAGCAATGTATAGTGGCCATCTTTGGTTACTTGATATTGGTGTTGTCAAGCTCCTGCAAATAATAGTAAATGTGCAAGGAGATG

>40092_40092_3_IPPK-ZNF484_IPPK_chr9_95432190_ENST00000287996_ZNF484_chr9_95618600_ENST00000395506_length(amino acids)=878AA_BP=30
MRLGMEEGKMDENEWGYHGEGNKSLVVAHAQESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNLISVGCQVPKPEVIFSLEQEE
PCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEININLFTRDDPYSILEELWKDDEHTRKCGENQNKPLSRVVFINKKTLANDSIFE
YKDIGEIVHVNTHLVSSRKRPHNCNSCGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHTEVTACECNQCGKPLHHKQALIQQQKI
HTRESLYLFSDYVNVFSPKSHAFAHESICAEEKQHECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYG
RAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTGEKPYVCTECGKAFIRK
SHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKH
QKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHTG
EKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQSHTGERHYEC
SECGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNRHRRIHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IPPK-ZNF484


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPPK-ZNF484


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPPK-ZNF484


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource