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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IQGAP1-RASGRF1 (FusionGDB2 ID:40165)

Fusion Gene Summary for IQGAP1-RASGRF1

Fusion gene summary

Fusion gene information	Fusion gene name: IQGAP1-RASGRF1
	Fusion gene ID: 40165
		Hgene	Tgene
	Gene symbol	IQGAP1	RASGRF1
	Gene ID	8826	5923
	Gene name	IQ motif containing GTPase activating protein 1	Ras protein specific guanine nucleotide releasing factor 1
	Synonyms	HUMORFA01\|SAR1\|p195	CDC25\|CDC25L\|GNRP\|GRF1\|GRF55\|H-GRF55\|PP13187\|ras-GRF1
	Cytomap	15q26.1	15q25.1
	Type of gene	protein-coding	protein-coding
	Description	ras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifs	ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re
	Modification date	20200327	20200313
	UniProtAcc	P46940	.
	Ensembl transtripts involved in fusion gene	ENST00000268182, ENST00000560020, ENST00000560738,	ENST00000560334, ENST00000394745, ENST00000419573, ENST00000558480,
Fusion gene scores	* DoF score	27 X 20 X 12=6480	24 X 19 X 4=1824
	# samples	32	24
	** MAII score	log2(32/6480*10)=-4.33985000288463 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/1824*10)=-2.92599941855622 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IQGAP1 [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IQGAP1(90934105)-RASGRF1(79298776), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IQGAP1	GO:0071277	cellular response to calcium ion	18567582

Fusion gene breakpoints across IQGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RASGRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-FX-A3TO-01A	IQGAP1	chr15	90934105	-	RASGRF1	chr15	79298776	-
ChimerDB4	SARC	TCGA-FX-A3TO-01A	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-

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Fusion Gene ORF analysis for IQGAP1-RASGRF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000268182	ENST00000560334	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
5CDS-intron	ENST00000268182	ENST00000394745	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
In-frame	ENST00000268182	ENST00000419573	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
In-frame	ENST00000268182	ENST00000558480	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-3CDS	ENST00000560020	ENST00000419573	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-3CDS	ENST00000560020	ENST00000558480	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-3CDS	ENST00000560738	ENST00000419573	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-3CDS	ENST00000560738	ENST00000558480	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-5UTR	ENST00000560020	ENST00000560334	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-5UTR	ENST00000560738	ENST00000560334	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-intron	ENST00000560020	ENST00000394745	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-
intron-intron	ENST00000560738	ENST00000394745	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000268182

IQGAP1

chr15

90934105

ENST00000558480

RASGRF1

chr15

79298776

4424

279

124

2226

700

ENST00000268182

IQGAP1

chr15

90934105

ENST00000419573

RASGRF1

chr15

79298776

4433

279

124

2235

703

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000268182	ENST00000558480	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-	0.003707179	0.99629277
ENST00000268182	ENST00000419573	IQGAP1	chr15	90934105	+	RASGRF1	chr15	79298776	-	0.0037512	0.9962488

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Fusion Genomic Features for IQGAP1-RASGRF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IQGAP1-RASGRF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90934105/chr15:79298776)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IQGAP1 P46940	.
FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269\|PubMed:15695813, ECO:0000269\|PubMed:20883816}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

1038_1270

490.0

Domain

Ras-GEF

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

204_229

490.0

Domain

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

22_129

490.0

Domain

PH 1

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

240_426

490.0

Domain

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

467_584

490.0

Domain

PH 2

Tgene

RASGRF1

chr15:90934105

chr15:79298776

ENST00000394745

644_761

490.0

Domain

N-terminal Ras-GEF

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

1004_1237

1658.0

Domain

Ras-GAP

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

44_159

1658.0

Domain

Calponin-homology (CH)

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

679_712

1658.0

Domain

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

745_774

1658.0

Domain

IQ 1

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

775_804

1658.0

Domain

IQ 2

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

805_834

1658.0

Domain

IQ 3

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

835_864

1658.0

Domain

IQ 4

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

1276_1657

1658.0

Region

Note=C2

Hgene

IQGAP1

chr15:90934105

chr15:79298776

ENST00000268182

956_1274

1658.0

Region

Note=C1

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Fusion Gene Sequence for IQGAP1-RASGRF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40165_40165_1_IQGAP1-RASGRF1_IQGAP1_chr15_90934105_ENST00000268182_RASGRF1_chr15_79298776_ENST00000419573_length(transcript)=4433nt_BP=279nt
GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA
CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC
TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA
AGCGAAGAGGTCCGACGCCTCCTTATATTGTGATGATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCG
CTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTGACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCG
CGTCTTCACCACCGCCATCGTGGTCCTGGACAAGCTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTGGCTGAGGTC
GCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAATAAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTC
GCCGCCACCTCTGTCCATCACCAAGACATCGTCACCGAGCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGC
CCTGGACCTGGCCGCCCTCAGCTGCAACTCCAATGGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACAC
CAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGATTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCT
CAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAGGAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAAC
TAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAAATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTC
CTGTCGTGAACTGGACAATAACCGCAGTGCCTTGTCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAA
CAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGC
AGCCACCAATCGTGTCTTGAACGTGCTCCGCCACTGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGT
GATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGCTCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCA
GGAGGACCCAGGTGACAACCAGATCACGCTGGAGGAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGC
CCTGGAGATCGCGGAGCAGCTGACCCTGCTAGATCACCTCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAA
ACTGGAAAAGAATGAAAGGACCCCTTATATCATGAAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCG
CAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGAAGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGT
ACTGGAGATCACCTCGTCCATGAACCGCAGTGCAATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGAT
TGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGCAGATTTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTA
CCTGGGGATGTACCTCACCGACCTGGCCTTCATCGAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAG
GATGATATCCCATATTATCCGAGAGATTCGCCAGTTTCAACAAACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACT
GGACCAATCTTTTGTAATGGATGAAGAAAGCCTCTACGAGTCTTCTCTCCGAATAGAACCAAAACTCCCCACCTGAAGCTGAGCCCAGCC
CAGACCCAGCTGCTCCCGGGGACATGTGCTAGATGATACTGTACATATTCGTTTGGTTTCACTGGATTTTCTTCTTCAGTATGTGCTTCT
CCAAGAATACAAATCGTCCTTGTTCTTAGATTCCTGTAGAACCGGAATATGAATTTCTGCACCGTTTCAGACTTCGCCCACCCATCCCTC
CCCTCGTCTCCTGCAGTGCCTGTTTCTTTTAAACAGCTGTACTCTTGGTCCCTCTTCCCTAGACTCCTCACTCTTCTCAGAGGGGAAACA
GCACCCTTGCATACAAGAATCTTAGACTCCAGTCCTGCTTCCGTCCCTCCCCAGCCCAGGCTCCTGGGTTGAGGTGGCCACCCAGGCATC
CTCCCAGCATGTTCCATGTAGTTGTTATAACTGGGTGGGGGGTGGGGGGCGGCGGGAGGGGGAAACCATACCCTGAAGTCCAGTCATTGA
CAAATCTTCCCGCTGATGGTGATGTCAATTTCCAAAGCAGCTTCTCCAGCCAAAATCGCAGGTCTCAAAACTCCCCATGTGTCTCCCAGT
AACCTGGACGGAAGGGAGTCCTCTCTGCTCAGAACCACACCCCTCGTACCAATGCTGCCATCTCGTTCAGGCCCCACGTCGCTCCTTGCT
CTAGGATTAACACCAGATAGCATGAATAGCAGTCTCAATACAACTGGATGAGGCCCTAGACTTCCCGAGGAAATGGAGTCACAAACACCA
AGCCACGTCGACTCTTGCCGACCACTGGCCCAGCATCCACTGAAAGTCGGGAACACAAAAATGTCACTTTTCCTCTTTAAGCTGCCTAAC
GGTCACTACAAGCTTACATTGAGATGCTCTAAGTCTGTATACCTTGTGATAATTAGTACCACACTGTAGAATTAGGAAATCAATAACCAA
GTGTTTTTATTGCATATACTGTAGTCCTGTCTAAATGCCTTCTAGCAGGAATATAGTAATGTAGTGCTTATTCTGTGAATATTACCATGT
ATTTTTTACACTGTACAGTATAGAAAACACAGGTTAACTCCGAAGTGGCAGGCATGCTCCACTACAACAGACAGACAACTTTTGCTGTAA
GCAATACCTAGTGGTATGAGAATTCTATTTCAAGTCCTAAAATATTTCAACTTACAGCTTGTTTGGAAAAAAATTTCCATTTTTGTAAAA
ATATATGTTTCCTGATTACCTCTTGCTAATAAATCTATTCTATCTCAGGGTGAACAGCGAGTTTTGATGGGTTTCATTCGTTCAGTCAAG
GAATATTTGATGAGCACTTGCTCCTTACCCAGCCCAGCCTGGGACCGGAGATCCAGAGTGTCAAGGACACCATACCTGCTTTTTAGGCAC
CAACAGTTTGGTGGGGAAGACTGTTTCAGTTGCCTATTGCACCAAGAACAAGCCACTCCAAAACATAATGGCTTAAAACCATTTTTGTTA
CCTTTCACAGTTCTATGGGTTGACTGGGTCCAGCTGTCAGTTCTTATTTGGAGTCTCTCATGAAGTTTCAGTCACTCAGCAACTGGGACT
GGAGTCATCTGAAGGCTCAACTGGACCGGGTGGTGCTCTAGTTGGTGCACCAAGATGGCGCTGTCACATGGCTGGATGTTGATGTCTGCT
GGGCTGCACTGGGGCTGTTCATGGGAGCATCCACACGTGGCCTCTCTGTGTGGCTTGGGCTCCTCACAGTCCGGAAGCTGGGTTCCAAGA
GCGACTGTTCCAGCAGCCTCAGGCAGAAGCTACAAGGCTGCCCAGATGCCATCCTGCCCAGATGTGTCCTCACTGTCACCCAGGAAGGGA
AGCCCCGGAACACCACCCTCAGTCACAGGCATGGGGCCCACTGCAAGGCACAACCCACTCCAGAGCTCCCAAGGCCGCCTCCCCTGGGAC
CTGCAGCCAGCTGGCTCCATAACTGCTTTTCCGTTTCCTCCAGGCATTTTCATCCTAGCCCTACTTTGTGCTGGGATCTGAGGGGGATAG
CAAGCGGAGAAAGAAGGGATCTAGAGGGAGAAGATTCTAGATCCTTCTTTTGACTGCCAGCTGATTTTGATTGCCAGCTTTACCTGCTTC
ATGAGCTCAGCCAAGTCACTTAACCTCTCAGAGCTTCACTGTTCTCATCTGAAAAATGGGGATGAAAATGGTATCTCATTACAGAGTAGA

>40165_40165_1_IQGAP1-RASGRF1_IQGAP1_chr15_90934105_ENST00000268182_RASGRF1_chr15_79298776_ENST00000419573_length(amino acids)=703AA_BP=51
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSS
PSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE
ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLAS
AGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE
EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAI
EKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI

--------------------------------------------------------------
>40165_40165_2_IQGAP1-RASGRF1_IQGAP1_chr15_90934105_ENST00000268182_RASGRF1_chr15_79298776_ENST00000558480_length(transcript)=4424nt_BP=279nt
GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA
CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC
TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA
AGCGAAGAGGTCCGACGCCTCCTTATATTGTGATGATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCG
CTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTGACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCG
CGTCTTCACCACCGCCATCGTGGTCCTGGACAAGCTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTCGCTGGAGCT
CCTGTTTGCCAGTGGCCAGAACAATAAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACC
TCTGTCCATCACCAAGACATCGTCACCGAGCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCT
GGCCGCCCTCAGCTGCAACTCCAATGGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCT
CTATGTGTCCAGCAGCTTCACCAACAAGATTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCA
GAGCTCAGAAGTCTCCATGAGAGAGGAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCC
AACAACACCCAAATCAGTCAAAAACAAAAATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGA
ACTGGACAATAACCGCAGTGCCTTGTCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAA
GTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAA
TCGTGTCTTGAACGTGCTCCGCCACTGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTT
CCTGGAAGAAGTCATGCACGACCCGGAGCTCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCC
AGGTGACAACCAGATCACGCTGGAGGAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGAT
CGCGGAGCAGCTGACCCTGCTAGATCACCTCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAA
GAATGAAAGGACCCCTTATATCATGAAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGA
CATCAACGCCAGGGTGAGCGCCATCGAGAAGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGAT
CACCTCGTCCATGAACCGCAGTGCAATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCT
CCAAAAGCTTGTGTCATCTGAGGGCAGATTTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGAT
GTACCTCACCGACCTGGCCTTCATCGAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATC
CCATATTATCCGAGAGATTCGCCAGTTTCAACAAACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACTGGACCAATC
TTTTGTAATGGATGAAGAAAGCCTCTACGAGTCTTCTCTCCGAATAGAACCAAAACTCCCCACCTGAAGCTGAGCCCAGCCCAGACCCAG
CTGCTCCCGGGGACATGTGCTAGATGATACTGTACATATTCGTTTGGTTTCACTGGATTTTCTTCTTCAGTATGTGCTTCTCCAAGAATA
CAAATCGTCCTTGTTCTTAGATTCCTGTAGAACCGGAATATGAATTTCTGCACCGTTTCAGACTTCGCCCACCCATCCCTCCCCTCGTCT
CCTGCAGTGCCTGTTTCTTTTAAACAGCTGTACTCTTGGTCCCTCTTCCCTAGACTCCTCACTCTTCTCAGAGGGGAAACAGCACCCTTG
CATACAAGAATCTTAGACTCCAGTCCTGCTTCCGTCCCTCCCCAGCCCAGGCTCCTGGGTTGAGGTGGCCACCCAGGCATCCTCCCAGCA
TGTTCCATGTAGTTGTTATAACTGGGTGGGGGGTGGGGGGCGGCGGGAGGGGGAAACCATACCCTGAAGTCCAGTCATTGACAAATCTTC
CCGCTGATGGTGATGTCAATTTCCAAAGCAGCTTCTCCAGCCAAAATCGCAGGTCTCAAAACTCCCCATGTGTCTCCCAGTAACCTGGAC
GGAAGGGAGTCCTCTCTGCTCAGAACCACACCCCTCGTACCAATGCTGCCATCTCGTTCAGGCCCCACGTCGCTCCTTGCTCTAGGATTA
ACACCAGATAGCATGAATAGCAGTCTCAATACAACTGGATGAGGCCCTAGACTTCCCGAGGAAATGGAGTCACAAACACCAAGCCACGTC
GACTCTTGCCGACCACTGGCCCAGCATCCACTGAAAGTCGGGAACACAAAAATGTCACTTTTCCTCTTTAAGCTGCCTAACGGTCACTAC
AAGCTTACATTGAGATGCTCTAAGTCTGTATACCTTGTGATAATTAGTACCACACTGTAGAATTAGGAAATCAATAACCAAGTGTTTTTA
TTGCATATACTGTAGTCCTGTCTAAATGCCTTCTAGCAGGAATATAGTAATGTAGTGCTTATTCTGTGAATATTACCATGTATTTTTTAC
ACTGTACAGTATAGAAAACACAGGTTAACTCCGAAGTGGCAGGCATGCTCCACTACAACAGACAGACAACTTTTGCTGTAAGCAATACCT
AGTGGTATGAGAATTCTATTTCAAGTCCTAAAATATTTCAACTTACAGCTTGTTTGGAAAAAAATTTCCATTTTTGTAAAAATATATGTT
TCCTGATTACCTCTTGCTAATAAATCTATTCTATCTCAGGGTGAACAGCGAGTTTTGATGGGTTTCATTCGTTCAGTCAAGGAATATTTG
ATGAGCACTTGCTCCTTACCCAGCCCAGCCTGGGACCGGAGATCCAGAGTGTCAAGGACACCATACCTGCTTTTTAGGCACCAACAGTTT
GGTGGGGAAGACTGTTTCAGTTGCCTATTGCACCAAGAACAAGCCACTCCAAAACATAATGGCTTAAAACCATTTTTGTTACCTTTCACA
GTTCTATGGGTTGACTGGGTCCAGCTGTCAGTTCTTATTTGGAGTCTCTCATGAAGTTTCAGTCACTCAGCAACTGGGACTGGAGTCATC
TGAAGGCTCAACTGGACCGGGTGGTGCTCTAGTTGGTGCACCAAGATGGCGCTGTCACATGGCTGGATGTTGATGTCTGCTGGGCTGCAC
TGGGGCTGTTCATGGGAGCATCCACACGTGGCCTCTCTGTGTGGCTTGGGCTCCTCACAGTCCGGAAGCTGGGTTCCAAGAGCGACTGTT
CCAGCAGCCTCAGGCAGAAGCTACAAGGCTGCCCAGATGCCATCCTGCCCAGATGTGTCCTCACTGTCACCCAGGAAGGGAAGCCCCGGA
ACACCACCCTCAGTCACAGGCATGGGGCCCACTGCAAGGCACAACCCACTCCAGAGCTCCCAAGGCCGCCTCCCCTGGGACCTGCAGCCA
GCTGGCTCCATAACTGCTTTTCCGTTTCCTCCAGGCATTTTCATCCTAGCCCTACTTTGTGCTGGGATCTGAGGGGGATAGCAAGCGGAG
AAAGAAGGGATCTAGAGGGAGAAGATTCTAGATCCTTCTTTTGACTGCCAGCTGATTTTGATTGCCAGCTTTACCTGCTTCATGAGCTCA
GCCAAGTCACTTAACCTCTCAGAGCTTCACTGTTCTCATCTGAAAAATGGGGATGAAAATGGTATCTCATTACAGAGTAGAATTAAATGA

>40165_40165_2_IQGAP1-RASGRF1_IQGAP1_chr15_90934105_ENST00000268182_RASGRF1_chr15_79298776_ENST00000558480_length(amino acids)=700AA_BP=51
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSR
RRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESD
IDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGF
PPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEIT
QMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKW
VAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG

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Fusion Gene PPI Analysis for IQGAP1-RASGRF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IQGAP1-RASGRF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IQGAP1-RASGRF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source