Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IQGAP2-ATRNL1 (FusionGDB2 ID:40180)

Fusion Gene Summary for IQGAP2-ATRNL1

Fusion gene summary

Fusion gene information	Fusion gene name: IQGAP2-ATRNL1
	Fusion gene ID: 40180
		Hgene	Tgene
	Gene symbol	IQGAP2	ATRNL1
	Gene ID	10788	26033
	Gene name	IQ motif containing GTPase activating protein 2	attractin like 1
	Synonyms	-	ALP\|bA338L11.1\|bA454H24.1
	Cytomap	5q13.3	10q25.3
	Type of gene	protein-coding	protein-coding
	Description	ras GTPase-activating-like protein IQGAP2	attractin-like protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q5VV63
	Ensembl transtripts involved in fusion gene	ENST00000274364, ENST00000379730, ENST00000396234, ENST00000502745, ENST00000508410,	ENST00000527407, ENST00000529665, ENST00000303745, ENST00000355044, ENST00000423111,
Fusion gene scores	* DoF score	7 X 6 X 3=126	9 X 7 X 5=315
	# samples	7	9
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IQGAP2 [Title/Abstract] AND ATRNL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IQGAP2(75866482)-ATRNL1(117278773), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IQGAP2	GO:0034314	Arp2/3 complex-mediated actin nucleation	12515716
Hgene	IQGAP2	GO:0070493	thrombin-activated receptor signaling pathway	12515716

Fusion gene breakpoints across IQGAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATRNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7243-01A	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+

Top

Fusion Gene ORF analysis for IQGAP2-ATRNL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000274364	ENST00000527407	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5CDS-intron	ENST00000274364	ENST00000529665	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5UTR-3CDS	ENST00000379730	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5UTR-3CDS	ENST00000379730	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5UTR-3CDS	ENST00000379730	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5UTR-intron	ENST00000379730	ENST00000527407	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
5UTR-intron	ENST00000379730	ENST00000529665	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
In-frame	ENST00000274364	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
In-frame	ENST00000274364	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
In-frame	ENST00000274364	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000396234	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000396234	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000396234	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000502745	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000502745	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000502745	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000508410	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000508410	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-3CDS	ENST00000508410	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000396234	ENST00000527407	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000396234	ENST00000529665	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000502745	ENST00000527407	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000502745	ENST00000529665	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000508410	ENST00000527407	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+
intron-intron	ENST00000508410	ENST00000529665	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000274364	IQGAP2	chr5	75866482	-	ENST00000355044	ATRNL1	chr10	117278773	+	5377	678	237	1163	308
ENST00000274364	IQGAP2	chr5	75866482	-	ENST00000423111	ATRNL1	chr10	117278773	+	1420	678	237	1163	308
ENST00000274364	IQGAP2	chr5	75866482	-	ENST00000303745	ATRNL1	chr10	117278773	+	1571	678	237	1163	308

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000274364	ENST00000355044	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+	0.001253073	0.9987469
ENST00000274364	ENST00000423111	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+	0.006161702	0.99383825
ENST00000274364	ENST00000303745	IQGAP2	chr5	75866482	-	ATRNL1	chr10	117278773	+	0.003995176	0.9960049

Top

Fusion Genomic Features for IQGAP2-ATRNL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IQGAP2-ATRNL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:75866482/chr10:117278773)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ATRNL1 Q5VV63
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May play a role in melanocortin signaling pathways that regulate energy homeostasis. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

1252_1379

1218

1380.0

Topological domain

Cytoplasmic

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

1231_1251

1218

1380.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

263_266

127

1576.0

Compositional bias

Note=Poly-Lys

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

263_266

1072.0

Compositional bias

Note=Poly-Lys

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

41_156

127

1576.0

Domain

Calponin-homology (CH)

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

594_627

127

1576.0

Domain

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

690_719

127

1576.0

Domain

IQ 1

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

720_749

127

1576.0

Domain

IQ 2

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

750_779

127

1576.0

Domain

IQ 3

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000274364

917_1150

127

1576.0

Domain

Ras-GAP

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

41_156

1072.0

Domain

Calponin-homology (CH)

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

594_627

1072.0

Domain

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

690_719

1072.0

Domain

IQ 1

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

720_749

1072.0

Domain

IQ 2

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

750_779

1072.0

Domain

IQ 3

Hgene

IQGAP2

chr5:75866482

chr10:117278773

ENST00000396234

917_1150

1072.0

Domain

Ras-GAP

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

1014_1059

1218

1380.0

Domain

Laminin EGF-like 1

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

1060_1108

1218

1380.0

Domain

Laminin EGF-like 2

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

207_245

1218

1380.0

Domain

EGF-like 2

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

53_91

1218

1380.0

Domain

EGF-like 1

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

614_657

1218

1380.0

Domain

Note=PSI 1

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

666_709

1218

1380.0

Domain

Note=PSI 2

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

715_760

1218

1380.0

Domain

Note=PSI 3

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

755_873

1218

1380.0

Domain

C-type lectin

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

889_939

1218

1380.0

Domain

Note=PSI 4

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

93_209

1218

1380.0

Domain

CUB

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

942_1012

1218

1380.0

Domain

Note=PSI 5

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

316_365

1218

1380.0

Repeat

Note=Kelch 1

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

367_415

1218

1380.0

Repeat

Note=Kelch 2

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

427_475

1218

1380.0

Repeat

Note=Kelch 3

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

480_531

1218

1380.0

Repeat

Note=Kelch 4

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

533_591

1218

1380.0

Repeat

Note=Kelch 5

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

592_638

1218

1380.0

Repeat

Note=Kelch 6

Tgene

ATRNL1

chr5:75866482

chr10:117278773

ENST00000355044

53_1230

1218

1380.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for IQGAP2-ATRNL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40180_40180_1_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000303745_length(transcript)=1571nt_BP=678nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT
GGTCACAGGTGATAAAGTCAGTTTTTACCACTATCTTAGGCTTATTATAGCTAACATTAAATTACTCTGGAAAAAGATGTATATTGTTTC
TTAATGAAGATGAAAAATATGTAATTCATATAAATCAACTGTTTATATCCCAAGACTTGAAAGAAAGACATTTTTTAATGCCTGAATGAT

>40180_40180_1_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000303745_length(amino acids)=308AA_BP=147
MASEGSRGGRAPGGPPETRRMPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLR
NGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVV
WKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGL

--------------------------------------------------------------
>40180_40180_2_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000355044_length(transcript)=5377nt_BP=678nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT
GGTCACAGGTGATAAAGTCAGTTTTTACCACTATCTTAGGCTTATTATAGCTAACATTAAATTACTCTGGAAAAAGATGTATATTGTTTC
TTAATGAAGATGAAAAATATGTAATTCATATAAATCAACTGTTTATATCCCAAGACTTGAAAGAAAGACATTTTTTAATGCCTGAATGAT
GAGAATTGTACAGTTTTTGCCTCATAAGCAAACTTGAATCACCTGTGTATGAACAGGGAATGAACACATTGCAATGGCTTTAAATGCTCT
TTTATCTCGTTGTAAAGGTAAGGCAAGATTTTGATGTAGTAGGATGTAGGTAATGTATTTAAATATTTCATATGACCATATCGTGTCCAA
ACTCAGTCTGAGAATGTGACAGCTTTCCGCCTAACTAGAATGCAGACCAGAATGAGTTCAACTCATTCTGTGCAACTTCACAGGGGGTTT
ATTAGAATGCTCAGTGTAGAGGACATTCCTGTCATCCATGCCAACTACCTAACTCGTTATCAGAGCTGATAGAGCATGGAAAAGTCTGTC
CAGCGATCAGTTGTTCCCCTCCTTCCAAAAACAGCCTCCAATACCACAACCTGAAAAGAGCCGAAATGGTTATTTTACAGCATACAAGCT
TCTGCTCCAGTATGATAATTTTTAATTGCCTAAGAATCATTGGATCAGACCTAAATGATCCATCTGCATTTTTATAAGAATGGATCTTTC
TTTGCCCTTCCTCTCCTAGCTGCTAGATTTTAACTACCTTTTACAAATGTTACAAAATGTATTTTAGAGGCGACATCTCTCAAGATGACC
TGAGTTCCTTCCTGCCAACTGTTCCACCTAGAATACAAGTAGAGAAGAGCACTGGCTGGCAAGCATCAACAGGAGTCTTCTTCCCAACAC
GAGCGCATCCATGTCCTGAGAAAAAGTCTGTGGTTTAGAAAATATGTCCATGGTTGCCCACAGTCAGCACACTCTTAGTGACTCAAAATT
CTGAATTATGGCAGAAAGGAAAAATAAAACATACTTCACATTAGAACACAGAATCATTTACATCCTAATACTGACCACAGTTCACTAAAG
CTCAGTAGCATTAACAGATATAGTTTGGAATTGCAGTTTCCTCACTTCAGGGTGACAAGATATGTATAACAGTGACAGAAATCTCCAAAG
CTGCTGTATATGATATAGCTTTGTTAAATATGAAGGTCCTTTAAATACAATTGATGTTTAGTACTATATATGTACTTTTCACATTCTTTG
GATTTCTGGAAGGTTATGACACTTTACTGTTTACAGCTAATGCATAGTTACTTGCATGCCATGGTTGTACAGTAGCAGACTATGACCCTA
TTGTGATATTAAGTGTTTATTTCATAATGCCATTTATACATAGCTGAATTTGATGAGGATTGAATGTCATATATAAGAGGAATGATCATA
CAATATGTAGTTGCATCTTATATAAGATTTCTAGGTTGCATCTAACCATGACTATGTCATTATTTTGATAATTAGGCATTTATGAATTAT
AGTATATATTCCTCATGTTGGCATGATAATTTTGCTATTTTCCATGCATTAAAAATAAGACAAATTCTTAGAGTAATTTTAGTAATTTTA
TCTATAATCTGTGGGGTTTTTTTGGAGGGGGAGGCCACTGGTTGTTTCTACTTCCCTGTGATATTTTCTCTCTCATTAAAGGAATGAGCT
AAGTTTGTAAATATCTCCTAAAAACAATCAAGTAATTTTATTAGCTTCTTTTGGACCCTCTAAATATTGACTTCTCTCATGAAAAAATAA
ATTGATGAAACTAATGATTACAAAGATATAATCATTTTTTAAAAAGTGATTGCCCAATGTATTTCTCTAACAATTGTCACAAGAGAAAGC
ATAACAATAAAAATACAAAAACATACAGATTTAGATGTAAAATCTATATAAGCTATATTTTTAGGGAGGCTAAGCAGATAGTATTACTGT
GGAAGAATTATCAAGTTTTATTCACCTCAAATCCCACTGGGTTCTTAAAACTTGAAAATTCAAATTGTAGAGAATTATGAGACACAATGT
GATGTTTAGTTAAAGTCATGCTATACCTTTCTGGGCCACATATTGCTAACTCTGTGGCTAATTATGCAATTAATTCTCAACGTATCAAAG
CTTTTCACTGGCAGTAAATTCTTTGCCCTCAGGTGAAGTGGATTGAAAAGACATCAAGGATCAAGGATAATCACTTTGAATCTGTTGGTT
TTTCCCCCTACATTCCAGACACTTTAAATTTGGATGCTTTCATTTTTTTTAAATCAAACCACACAAATATGCAGATACTTTCCCAGAATT
TCGCAGTTAAATGGCTGATCCTCTTGAAAACTAACCTTAATGGAATTCTAAACATTTCAGTTTAGAATGACTTTGAAAAATTCCTTAGAT
TTTTAGGATGTTTTATTCTGCCAAGTATGAAAAAAAAATGGTTAAATACAATGGAGTTTTAAAAATTAACCTGGGGATTCTATTTGAACT
AGAAAATTCCTATTGGAAAAGAATTTGCACATACTTACAGATTCAGCTAATAAATTTTAAGAGGATTAGGATTCTCATAATTCTTTAAAT
GAAAATTTGTTTTAGTGATACACAGAGATGCCGTATACTATAGTGTTATGTTCAGTAGGAAAACTTCAAATAGTTCGTATTTAAAAAGGT
AATTGATCCTTGCTGTACTTCCCAACATCTCATCTTCTTTTAGCTGCAGTAAGATAGAGGTGACTGTATGGCTACAGTTCATGGTATAAG
GTCATTTAGGGTGCACACTGGCACACAGGCTGGAAAACGGGCACTGGACCCAGCTTTCAGGTGTGTGGTGCTGGGTAAGTTTCACCTTTG
AAGCCTCAGCCTTCCATCTGTAAAGGGCGGTAATGGTGCCCACCTTTCGAGGCATTGCGAGGCTAGATGGTAACACACAGAAAGCTCCCA
CAGTGGGACCTTGATGCAGCGTAGCTGGTATTAACAACCGTGGGGACACCAGGCCACTCTTTTTCTACCAGTTGTTTTATGAATCCACCT
ATTAATTTTCATCCATCTTTTGGTCGTAGGTAAAGGTCAATCAGGTTTTTCAAAAAGACTCCCTGAATAACTTAAGTTCCTGTATTTCTA
AGATATAGGGATTTCTACAAAACGACTTTGACATTTAGTCAATAAAGACTTAAACTCTTCTTAAATCTATAGTTTTAGGAGAGTTTTTCT
TAAAATTACTGACTGATGACATTGAGACAAGAGCATCAATGATCACCTTTCACGTACAAACTAGGCAAGACAGGGTCAGTGCTTACATTT
TGTGGTTATACATGATACATCTTTTCTCAGTGAACATAAAACTATGATTTGAAAGGTGTCTTATATTTAAAAAAGATTGTAAAATGAAAA
CTGACCAAATGAACTAATTCTACCCACCTATGGTCTTTTTAAATGTCGAGTTTCAAAACCCATTTGCCGTATACTAGAGTGAGCTTGGAA
ACTTACCTGATTACAGGAATTGCTTGGGTTCAGGCAGATTCCCACTTTCACCTCTAGAGATTTAGATTCAGAAACACTGGGGTAGGCCCT
GGAGAGCAGTACTCTTAACAAGCTCCTCAGTGCTTCTTACCATTAGGCAAATTAGGGAAACACTGCATTGGGTCAAAGTGCTGCCTTTAA
TCGACCATTAGAGGGAGTTCTCTAAATAACAAAGTTATTACTCTAATTCAAAATGCTTTAAAGAATTTTCCAAGGAATACAAGCCATCTG
GTTGGTGTTAGTTATAGCAGTGATTTCATTAGAGTGTACATTTAACATTTTAGTTTTATCAAAATTTTTTGAAATTAAGAATTAGAACCA
GAGCTCCTATCAGTATATATGTACACAGGTGTGCATGCCAGTGTTCAAAAGATTGTGTAAAAGTTCAAGCCCGTTTTAGAAAGCCAACAT

>40180_40180_2_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000355044_length(amino acids)=308AA_BP=147
MASEGSRGGRAPGGPPETRRMPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLR
NGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVV
WKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGL

--------------------------------------------------------------
>40180_40180_3_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000423111_length(transcript)=1420nt_BP=678nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT

>40180_40180_3_IQGAP2-ATRNL1_IQGAP2_chr5_75866482_ENST00000274364_ATRNL1_chr10_117278773_ENST00000423111_length(amino acids)=308AA_BP=147
MASEGSRGGRAPGGPPETRRMPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLR
NGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVV
WKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IQGAP2-ATRNL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IQGAP2-ATRNL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IQGAP2-ATRNL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source