FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:IRAK2-FANCD2 (FusionGDB2 ID:40213)

Fusion Gene Summary for IRAK2-FANCD2

check button Fusion gene summary
Fusion gene informationFusion gene name: IRAK2-FANCD2
Fusion gene ID: 40213
HgeneTgene
Gene symbol

IRAK2

FANCD2

Gene ID

3656

2177

Gene nameinterleukin 1 receptor associated kinase 2FA complementation group D2
SynonymsIRAK-2FA-D2|FA4|FACD|FAD|FAD2|FANCD
Cytomap

3p25.3

3p25.3

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor-associated kinase-like 2Fanconi anemia group D2 proteinFanconi anemia complementation group D2
Modification date2020031320200313
UniProtAcc.

Q96PS1

Ensembl transtripts involved in fusion geneENST00000256458, ENST00000431693, 
ENST00000438741, ENST00000383806, 
ENST00000287647, ENST00000383807, 
ENST00000419585, 
Fusion gene scores* DoF score7 X 8 X 8=4489 X 13 X 7=819
# samples 811
** MAII scorelog2(8/448*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/819*10)=-2.89635992811635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IRAK2 [Title/Abstract] AND FANCD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIRAK2(10268117)-FANCD2(10133865), # samples:1
Anticipated loss of major functional domain due to fusion event.IRAK2-FANCD2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
IRAK2-FANCD2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
IRAK2-FANCD2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFANCD2

GO:0010332

response to gamma radiation

12874027


check buttonFusion gene breakpoints across IRAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FANCD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2EX-01AIRAK2chr3

10268117

+FANCD2chr3

10133865

+


Top

Fusion Gene ORF analysis for IRAK2-FANCD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000256458ENST00000431693IRAK2chr3

10268117

+FANCD2chr3

10133865

+
5CDS-intronENST00000256458ENST00000438741IRAK2chr3

10268117

+FANCD2chr3

10133865

+
Frame-shiftENST00000256458ENST00000383806IRAK2chr3

10268117

+FANCD2chr3

10133865

+
In-frameENST00000256458ENST00000287647IRAK2chr3

10268117

+FANCD2chr3

10133865

+
In-frameENST00000256458ENST00000383807IRAK2chr3

10268117

+FANCD2chr3

10133865

+
In-frameENST00000256458ENST00000419585IRAK2chr3

10268117

+FANCD2chr3

10133865

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256458IRAK2chr310268117+ENST00000287647FANCD2chr310133865+27111362902000636
ENST00000256458IRAK2chr310268117+ENST00000383807FANCD2chr310133865+26091362901940616
ENST00000256458IRAK2chr310268117+ENST00000419585FANCD2chr310133865+26091362901940616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256458ENST00000287647IRAK2chr310268117+FANCD2chr310133865+0.0111851650.9888149
ENST00000256458ENST00000383807IRAK2chr310268117+FANCD2chr310133865+0.0046365270.9953635
ENST00000256458ENST00000419585IRAK2chr310268117+FANCD2chr310133865+0.0046365270.9953635

Top

Fusion Genomic Features for IRAK2-FANCD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IRAK2chr310268117+FANCD2chr310133864+1.89E-060.9999981
IRAK2chr310268117+FANCD2chr310133864+1.89E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for IRAK2-FANCD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:10268117/chr3:10133865)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FANCD2

Q96PS1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIRAK2chr3:10268117chr3:10133865ENST00000256458+101313_94424626.0DomainNote=Death
HgeneIRAK2chr3:10268117chr3:10133865ENST00000256458+1013216_224424626.0Nucleotide bindingATP
HgeneIRAK2chr3:10268117chr3:10133865ENST00000256458+1013337_340424626.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIRAK2chr3:10268117chr3:10133865ENST00000256458+1013210_489424626.0DomainProtein kinase


Top

Fusion Gene Sequence for IRAK2-FANCD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40213_40213_1_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000287647_length(transcript)=2711nt_BP=1362nt
TTCCCCGCCGGTCCGCCCCTGGCTAGAGAAGCCGCAGCCCGCAGTGTCCGACCCAGTCGTCCCGCGCCGGAGCCGGCCCCGTAGCGTGCC
ATGGCCTGCTACATCTACCAGCTGCCCTCCTGGGTGCTGGACGACCTGTGCCGCAACATGGACGCGCTCAGCGAGTGGGACTGGATGGAG
TTCGCCTCCTACGTGATCACAGACCTGACCCAGCTGCGGAAGATCAAGTCCATGGAGCGGGTGCAGGGTGTGAGCATCACGCGGGAGCTG
CTGTGGTGGTGGGGCATGCGGCAGGCCACCGTCCAGCAACTTGTGGACCTCCTGTGCCGCCTGGAGCTCTACCGGGCTGCCCAGATCATC
CTGAACTGGAAACCGGCTCCTGAAATCAGGTGTCCCATTCCAGCCTTCCCTGACTCTGTGAAGCCAGAAAAGCCTTTGGCAGCTTCTGTA
AGAAAGGCTGAGGATGAACAGGAAGAGGGGCAGCCTGTGAGGATGGCCACCTTTCCAGGCCCAGGGTCCTCTCCAGCCAGAGCCCACCAG
CCGGCCTTTCTCCAGCCTCCTGAAGAAGATGCCCCTCATTCCTTGAGAAGCGACCTCCCCACTTCGTCTGATTCAAAGGACTTCAGCACC
TCCATTCCTAAGCAGGAAAAACTTTTGAGCTTGGCTGGAGACAGCCTTTTCTGGAGTGAGGCAGACGTGGTCCAGGCAACCGATGACTTC
AATCAAAACCGCAAAATCAGCCAGGGGACCTTTGCTGACGTCTACAGAGGGCACAGGCACGGGAAGCCATTCGTCTTCAAGAAGCTCAGA
GAGACAGCCTGTTCAAGTCCAGGATCAATCGAAAGATTCTTCCAGGCAGAGTTGCAGATTTGTCTTAGATGCTGCCACCCCAATGTCTTA
CCTGTGCTGGGCTTCTGTGCTGCAAGACAGTTTCACAGCTTCATCTACCCCTACATGGCAAATGGTTCCCTACAGGACAGACTGCAGGGT
CAGGGTGGCTCGGACCCCCTCCCCTGGCCCCAGCGTGTCAGCATCTGCTCAGGGCTGCTCTGTGCCGTCGAGTACCTGCATGGTCTGGAG
ATCATCCACAGCAACGTCAAGAGCTCTAATGTCTTGCTGGACCAAAATCTCACCCCCAAACTTGCTCACCCAATGGCTCATCTGTGTCCT
GTCAACAAAAGGTCAAAATACACCATGATGAAGACTCACCTGCTCCGGACGTCAGCCGCGTATCTGCCAGAGGATTTCATCCGGGTGGGG
CAGCTGACAAAGCGAGTGGACATCTTCAGCTGTGGAATAGTGTTGGCCGAGGTCCTCACGGGCATCCCTGCAATGGATAACAACCGAAGC
CCGGTTTACCTGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGTTCGAGACTTCAGTATCCTCATCAACTTGATAAAGGTATTT
GATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATGCCGCTCCTAGACTTC
AGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCAGTTGGACACAAGGCTGCTTCATCACCTGTGTGGGCATTCC
AAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCTATGCTC
ACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAGTCCCAAAATTCCCAG
GAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAAGAGCAAAGCCACTGAGGTATCTCTACAAAACCCACCAGAG
TCTGGCACTGATGGTTGCATTTTGTTAATTGTTCTAAGTTGGTGGAGCAGAACTTTGCCTACTTATGTTTATTGTCAAATGCTTCTATGC
CCATTTCCATTCCCTCCATAACAGCTTCTGTGCTTATATAATTTTTGGGACCCAGAAGAAACAACGACACAATCTTAGAATCACTCCTGA
GTATCTCGAGTTGTGGCATTTGTTATAGAGTTGACAATTTTCTGCATTATAGCCTCTCATTTTCCATGAATTCATATCTGAAACCATTTT
AGAAGGGAGAAGTCATCGAAGTATTTTCTGAGTGTTGAGAAGAATGAGTTAAACCATTTAAACACATTTGAAACATACAAAAATAGAAAT
GTGAAAGCATTTGGTGAAAGCCAAAGCACAGAGTCAGAAGCTGCCACCTTAGAGAACTGAAATAAAAATAGAAGTTCTTACGCTTTTTTG
TGGTACAGATGCTTTCGACAATTTAAAGAAAGCTAAATAAAAATGTAGACATGGCTGGCGCAGTGGCTCATGCTTGTAATCCTAGCACTT
TTTGAGGCCAAGGTAGGAGGATTGCTTGAGTCCGGGAGCTCAAGGCAAAGCTGCACAACATAACAAGACCCTATCTCCACAAAAAAAATG
AAAAATAAACCTGGGTGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGATGTGGGCAGATCACAAGGTCAGGAGTTCAAGA
CCAGCCTGGCCAACATAGTGAAACCCCATCTCTACTGAAAATACAAAAATTAGCTGGGTGTGGTGGCACGTGCCTGTTATCTCAGCTACT

>40213_40213_1_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000287647_length(amino acids)=636AA_BP=424
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQII
LNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVL
PVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLIHEEKLLYWNMAVRDFSILINLIKVF
DSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAML
TLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTADESEDDMSSQASKSKATEVSLQNPPESGTDGCILLIVLSWWSRTLPTYVYCQMLLC

--------------------------------------------------------------
>40213_40213_2_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000383807_length(transcript)=2609nt_BP=1362nt
TTCCCCGCCGGTCCGCCCCTGGCTAGAGAAGCCGCAGCCCGCAGTGTCCGACCCAGTCGTCCCGCGCCGGAGCCGGCCCCGTAGCGTGCC
ATGGCCTGCTACATCTACCAGCTGCCCTCCTGGGTGCTGGACGACCTGTGCCGCAACATGGACGCGCTCAGCGAGTGGGACTGGATGGAG
TTCGCCTCCTACGTGATCACAGACCTGACCCAGCTGCGGAAGATCAAGTCCATGGAGCGGGTGCAGGGTGTGAGCATCACGCGGGAGCTG
CTGTGGTGGTGGGGCATGCGGCAGGCCACCGTCCAGCAACTTGTGGACCTCCTGTGCCGCCTGGAGCTCTACCGGGCTGCCCAGATCATC
CTGAACTGGAAACCGGCTCCTGAAATCAGGTGTCCCATTCCAGCCTTCCCTGACTCTGTGAAGCCAGAAAAGCCTTTGGCAGCTTCTGTA
AGAAAGGCTGAGGATGAACAGGAAGAGGGGCAGCCTGTGAGGATGGCCACCTTTCCAGGCCCAGGGTCCTCTCCAGCCAGAGCCCACCAG
CCGGCCTTTCTCCAGCCTCCTGAAGAAGATGCCCCTCATTCCTTGAGAAGCGACCTCCCCACTTCGTCTGATTCAAAGGACTTCAGCACC
TCCATTCCTAAGCAGGAAAAACTTTTGAGCTTGGCTGGAGACAGCCTTTTCTGGAGTGAGGCAGACGTGGTCCAGGCAACCGATGACTTC
AATCAAAACCGCAAAATCAGCCAGGGGACCTTTGCTGACGTCTACAGAGGGCACAGGCACGGGAAGCCATTCGTCTTCAAGAAGCTCAGA
GAGACAGCCTGTTCAAGTCCAGGATCAATCGAAAGATTCTTCCAGGCAGAGTTGCAGATTTGTCTTAGATGCTGCCACCCCAATGTCTTA
CCTGTGCTGGGCTTCTGTGCTGCAAGACAGTTTCACAGCTTCATCTACCCCTACATGGCAAATGGTTCCCTACAGGACAGACTGCAGGGT
CAGGGTGGCTCGGACCCCCTCCCCTGGCCCCAGCGTGTCAGCATCTGCTCAGGGCTGCTCTGTGCCGTCGAGTACCTGCATGGTCTGGAG
ATCATCCACAGCAACGTCAAGAGCTCTAATGTCTTGCTGGACCAAAATCTCACCCCCAAACTTGCTCACCCAATGGCTCATCTGTGTCCT
GTCAACAAAAGGTCAAAATACACCATGATGAAGACTCACCTGCTCCGGACGTCAGCCGCGTATCTGCCAGAGGATTTCATCCGGGTGGGG
CAGCTGACAAAGCGAGTGGACATCTTCAGCTGTGGAATAGTGTTGGCCGAGGTCCTCACGGGCATCCCTGCAATGGATAACAACCGAAGC
CCGGTTTACCTGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGTTCGAGACTTCAGTATCCTCATCAACTTGATAAAGGTATTT
GATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATGCCGCTCCTAGACTTC
AGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCAGTTGGACACAAGGCTGCTTCATCACCTGTGTGGGCATTCC
AAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCTATGCTC
ACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAGTCCCAAAATTCCCAG
GAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAAGAGCAAAGCCACTGAGGATGGTGAAGAAGACGAAGTAAGT
GCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGATGACTCTGATTAGACCCCAGATAAATTGTTGCCTGCTTCTGTGTCTCTGCCA
GCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGTTTGCCTTTCTTACTGGTAGGATCCTTTTTTGTTCCTCTTTTTTTTTTTTTT
TTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAGGCTGGAGTGCAGTGCTGCAATCTTGGCTCACTGCAACCTCCATCTCCTAGG
TTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCACATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGA
TACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTCCTGAACTCATGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG
CATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGTGGGGTCTTTATTAACTTGTGGACATCATGGATTGTCTAACACCATCACAGT
CCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTTTGGATAAACCCAGCTGTGCTACACTGCAGAGTAAAATCTCTGAGTCATGAT

>40213_40213_2_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000383807_length(amino acids)=616AA_BP=424
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQII
LNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVL
PVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLIHEEKLLYWNMAVRDFSILINLIKVF
DSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAML

--------------------------------------------------------------
>40213_40213_3_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000419585_length(transcript)=2609nt_BP=1362nt
TTCCCCGCCGGTCCGCCCCTGGCTAGAGAAGCCGCAGCCCGCAGTGTCCGACCCAGTCGTCCCGCGCCGGAGCCGGCCCCGTAGCGTGCC
ATGGCCTGCTACATCTACCAGCTGCCCTCCTGGGTGCTGGACGACCTGTGCCGCAACATGGACGCGCTCAGCGAGTGGGACTGGATGGAG
TTCGCCTCCTACGTGATCACAGACCTGACCCAGCTGCGGAAGATCAAGTCCATGGAGCGGGTGCAGGGTGTGAGCATCACGCGGGAGCTG
CTGTGGTGGTGGGGCATGCGGCAGGCCACCGTCCAGCAACTTGTGGACCTCCTGTGCCGCCTGGAGCTCTACCGGGCTGCCCAGATCATC
CTGAACTGGAAACCGGCTCCTGAAATCAGGTGTCCCATTCCAGCCTTCCCTGACTCTGTGAAGCCAGAAAAGCCTTTGGCAGCTTCTGTA
AGAAAGGCTGAGGATGAACAGGAAGAGGGGCAGCCTGTGAGGATGGCCACCTTTCCAGGCCCAGGGTCCTCTCCAGCCAGAGCCCACCAG
CCGGCCTTTCTCCAGCCTCCTGAAGAAGATGCCCCTCATTCCTTGAGAAGCGACCTCCCCACTTCGTCTGATTCAAAGGACTTCAGCACC
TCCATTCCTAAGCAGGAAAAACTTTTGAGCTTGGCTGGAGACAGCCTTTTCTGGAGTGAGGCAGACGTGGTCCAGGCAACCGATGACTTC
AATCAAAACCGCAAAATCAGCCAGGGGACCTTTGCTGACGTCTACAGAGGGCACAGGCACGGGAAGCCATTCGTCTTCAAGAAGCTCAGA
GAGACAGCCTGTTCAAGTCCAGGATCAATCGAAAGATTCTTCCAGGCAGAGTTGCAGATTTGTCTTAGATGCTGCCACCCCAATGTCTTA
CCTGTGCTGGGCTTCTGTGCTGCAAGACAGTTTCACAGCTTCATCTACCCCTACATGGCAAATGGTTCCCTACAGGACAGACTGCAGGGT
CAGGGTGGCTCGGACCCCCTCCCCTGGCCCCAGCGTGTCAGCATCTGCTCAGGGCTGCTCTGTGCCGTCGAGTACCTGCATGGTCTGGAG
ATCATCCACAGCAACGTCAAGAGCTCTAATGTCTTGCTGGACCAAAATCTCACCCCCAAACTTGCTCACCCAATGGCTCATCTGTGTCCT
GTCAACAAAAGGTCAAAATACACCATGATGAAGACTCACCTGCTCCGGACGTCAGCCGCGTATCTGCCAGAGGATTTCATCCGGGTGGGG
CAGCTGACAAAGCGAGTGGACATCTTCAGCTGTGGAATAGTGTTGGCCGAGGTCCTCACGGGCATCCCTGCAATGGATAACAACCGAAGC
CCGGTTTACCTGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGTTCGAGACTTCAGTATCCTCATCAACTTGATAAAGGTATTT
GATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATGCCGCTCCTAGACTTC
AGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCAGTTGGACACAAGGCTGCTTCATCACCTGTGTGGGCATTCC
AAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCTATGCTC
ACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAGTCCCAAAATTCCCAG
GAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAAGAGCAAAGCCACTGAGGATGGTGAAGAAGACGAAGTAAGT
GCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGATGACTCTGATTAGACCCCAGATAAATTGTTGCCTGCTTCTGTGTCTCTGCCA
GCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGTTTGCCTTTCTTACTGGTAGGATCCTTTTTTGTTCCTCTTTTTTTTTTTTTT
TTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAGGCTGGAGTGCAGTGCTGCAATCTTGGCTCACTGCAACCTCCATCTCCTAGG
TTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCACATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGA
TACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTCCTGAACTCATGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG
CATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGTGGGGTCTTTATTAACTTGTGGACATCATGGATTGTCTAACACCATCACAGT
CCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTTTGGATAAACCCAGCTGTGCTACACTGCAGAGTAAAATCTCTGAGTCATGAT

>40213_40213_3_IRAK2-FANCD2_IRAK2_chr3_10268117_ENST00000256458_FANCD2_chr3_10133865_ENST00000419585_length(amino acids)=616AA_BP=424
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQII
LNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVL
PVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLIHEEKLLYWNMAVRDFSILINLIKVF
DSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAML

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IRAK2-FANCD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneFANCD2chr3:10268117chr3:10133865ENST0000043169308248_3590242.0BRCA2
TgeneFANCD2chr3:10268117chr3:10133865ENST00000431693081_2910242.0FANCE


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFANCD2chr3:10268117chr3:10133865ENST000002876473643248_3591259.01472.0BRCA2
TgeneFANCD2chr3:10268117chr3:10133865ENST000003838063543248_3591227.66666666666671469.6666666666667BRCA2
TgeneFANCD2chr3:10268117chr3:10133865ENST000003838073644248_3591259.01452.0BRCA2
TgeneFANCD2chr3:10268117chr3:10133865ENST000004195853644248_3591259.01452.0BRCA2
TgeneFANCD2chr3:10268117chr3:10133865ENST0000028764736431_2911259.01472.0FANCE
TgeneFANCD2chr3:10268117chr3:10133865ENST0000038380635431_2911227.66666666666671469.6666666666667FANCE
TgeneFANCD2chr3:10268117chr3:10133865ENST0000038380736441_2911259.01452.0FANCE
TgeneFANCD2chr3:10268117chr3:10133865ENST0000041958536441_2911259.01452.0FANCE


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for IRAK2-FANCD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for IRAK2-FANCD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource