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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IRAK2-SRGAP3 (FusionGDB2 ID:40216) |
Fusion Gene Summary for IRAK2-SRGAP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IRAK2-SRGAP3 | Fusion gene ID: 40216 | Hgene | Tgene | Gene symbol | IRAK2 | SRGAP3 | Gene ID | 3656 | 23380 |
| Gene name | interleukin 1 receptor associated kinase 2 | SLIT-ROBO Rho GTPase activating protein 2 | |
| Synonyms | IRAK-2 | ARHGAP34|FNBP2|SRGAP2A|SRGAP3 | |
| Cytomap | 3p25.3 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-1 receptor-associated kinase-like 2 | SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000256458, | ENST00000433332, ENST00000360413, ENST00000383836, | |
| Fusion gene scores | * DoF score | 7 X 8 X 8=448 | 5 X 5 X 3=75 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/448*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IRAK2 [Title/Abstract] AND SRGAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IRAK2(10206732)-SRGAP3(9166601), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRGAP3 | GO:0043547 | positive regulation of GTPase activity | 21148482 |
| Tgene | SRGAP3 | GO:0046847 | filopodium assembly | 22559944 |
| Tgene | SRGAP3 | GO:0051014 | actin filament severing | 21148482 |
| Tgene | SRGAP3 | GO:0060996 | dendritic spine development | 22559944 |
| Tgene | SRGAP3 | GO:2001223 | negative regulation of neuron migration | 22559944 |
| Fusion gene breakpoints across IRAK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SRGAP3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CV-7430-01A | IRAK2 | chr3 | 10206732 | - | SRGAP3 | chr3 | 9166601 | - |
| ChimerDB4 | HNSC | TCGA-CV-7430-01A | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - |
| ChimerDB4 | HNSC | TCGA-CV-7430 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - |
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Fusion Gene ORF analysis for IRAK2-SRGAP3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000256458 | ENST00000433332 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - |
| In-frame | ENST00000256458 | ENST00000360413 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - |
| In-frame | ENST00000256458 | ENST00000383836 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000256458 | IRAK2 | chr3 | 10206732 | + | ENST00000383836 | SRGAP3 | chr3 | 9166601 | - | 8345 | 184 | 90 | 3416 | 1108 |
| ENST00000256458 | IRAK2 | chr3 | 10206732 | + | ENST00000360413 | SRGAP3 | chr3 | 9166601 | - | 8270 | 184 | 90 | 3344 | 1084 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000256458 | ENST00000383836 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - | 0.000814804 | 0.99918514 |
| ENST00000256458 | ENST00000360413 | IRAK2 | chr3 | 10206732 | + | SRGAP3 | chr3 | 9166601 | - | 0.000529617 | 0.9994704 |
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Fusion Genomic Features for IRAK2-SRGAP3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IRAK2-SRGAP3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:10206732/chr3:9166601) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000360413 | 0 | 22 | 352_392 | 22 | 1076.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000360413 | 0 | 22 | 952_987 | 22 | 1076.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000383836 | 0 | 22 | 352_392 | 22 | 1100.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000383836 | 0 | 22 | 952_987 | 22 | 1100.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000360413 | 0 | 22 | 482_670 | 22 | 1076.0 | Domain | Rho-GAP | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000360413 | 0 | 22 | 744_803 | 22 | 1076.0 | Domain | SH3 | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000383836 | 0 | 22 | 482_670 | 22 | 1100.0 | Domain | Rho-GAP | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000383836 | 0 | 22 | 744_803 | 22 | 1100.0 | Domain | SH3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IRAK2 | chr3:10206732 | chr3:9166601 | ENST00000256458 | + | 1 | 13 | 13_94 | 31 | 626.0 | Domain | Note=Death |
| Hgene | IRAK2 | chr3:10206732 | chr3:9166601 | ENST00000256458 | + | 1 | 13 | 210_489 | 31 | 626.0 | Domain | Protein kinase |
| Hgene | IRAK2 | chr3:10206732 | chr3:9166601 | ENST00000256458 | + | 1 | 13 | 216_224 | 31 | 626.0 | Nucleotide binding | ATP |
| Hgene | IRAK2 | chr3:10206732 | chr3:9166601 | ENST00000256458 | + | 1 | 13 | 337_340 | 31 | 626.0 | Nucleotide binding | ATP |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000360413 | 0 | 22 | 19_314 | 22 | 1076.0 | Domain | F-BAR | |
| Tgene | SRGAP3 | chr3:10206732 | chr3:9166601 | ENST00000383836 | 0 | 22 | 19_314 | 22 | 1100.0 | Domain | F-BAR |
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Fusion Gene Sequence for IRAK2-SRGAP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >40216_40216_1_IRAK2-SRGAP3_IRAK2_chr3_10206732_ENST00000256458_SRGAP3_chr3_9166601_ENST00000360413_length(transcript)=8270nt_BP=184nt TTCCCCGCCGGTCCGCCCCTGGCTAGAGAAGCCGCAGCCCGCAGTGTCCGACCCAGTCGTCCCGCGCCGGAGCCGGCCCCGTAGCGTGCC ATGGCCTGCTACATCTACCAGCTGCCCTCCTGGGTGCTGGACGACCTGTGCCGCAACATGGACGCGCTCAGCGAGTGGGACTGGATGGAG TTCGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGCAATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAG TTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGGAGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCC CGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACTGTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGA GACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCCTCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAG AGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCAATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCAT GCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGGAGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAAC CTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGATTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAG AACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGGCAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGAT GTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGGCCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTG GAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACAACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATG TGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACATGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTC CAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCACCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGAT GCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATGTCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTC AAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGAGGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACA AAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGGCCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAA AGAGCAGAATGCGGCACCACCAGAGGAAGAAGAAATGCTCGAACCAGGAACCAGGATTCAGGACAAGCTATACCGCTTGTAGTCGAGAGC TGCATCCGTTACATCAATTTATATGGACTCCAGCAGCAGGGGATCTTCAGAGTGCCAGGATCTCAGGTGGAAGTCAATGACATCAAAAAT TCCTTTGAGAGAGGTGAAGACCCCCTTGTGGACGATCAAAATGAACGAGATATCAATTCAGTCGCTGGTGTTTTAAAACTGTATTTCCGA GGACTGGAAAACCCACTCTTTCCTAAGGAAAGGTTTCAAGATTTGATATCTACTATTAAACTGGAGAACCCAGCCGAGAGGGTGCACCAG ATCCAACAAATCCTCGTCACCCTTCCCCGCGTGGTCATTGTGGTCATGAGATACCTCTTCGCTTTCCTCAACCACCTCTCCCAGTATAGC GACGAGAACATGATGGATCCCTACAACCTGGCCATCTGCTTCGGGCCTACCCTCATGCACATCCCTGATGGGCAGGACCCTGTGTCCTGC CAGGCACACATCAATGAAGTCATCAAAACCATCATCATCCATCATGAAGCCATCTTCCCCAGCCCCCGGGAGCTAGAGGGACCTGTGTAT GAAAAATGCATGGCTGGAGGGGAAGAATATTGTGACAGCCCACACAGCGAGCCAGGGGCCATCGATGAAGTTGACCATGACAATGGCACT GAGCCTCATACCAGCGATGAAGAAGTGGAGCAGATCGAGGCTATTGCCAAGTTTGACTACATGGGGCGGTCCCCGCGTGAGCTATCCTTC AAGAAGGGGGCCTCGCTGCTCCTGTACCACCGCGCCTCGGAGGACTGGTGGGAGGGCCGGCACAACGGCGTGGATGGACTCATCCCCCAT CAGTACATAGTTGTACAGGACATGGATGATGCCTTCTCCGACAGCCTGAGCCAGAAGGCTGACAGCGAGGCCAGCAGTGGGCCATTGCTG GATGACAAGGCCTCTTCCAAAAACGACCTCCAGTCCCCCACGGAGCACATCTCGGATTACGGCTTTGGGGGGGTGATGGGCCGAGTGCGG TTACGATCTGATGGAGCAGCCATCCCCAGACGCCGAAGCGGGGGCGACACACACAGCCCGCCCCGGGGCCTGGGCCCCAGCATAGACACA CCACCCCGGGCTGCTGCCTGCCCCAGCAGCCCCCACAAAATCCCCCTCACCCGGGGGAGGATCGAGAGCCCTGAGAAGCGGAGGATGGCG ACGTTCGGGAGCGCTGGCAGCATCAACTACCCTGACAAGAAGGCGCTCTCCGAAGGGCACTCGATGAGGTCGACCTGCGGTTCCACCAGG CACAGCAGCCTAGGGGACCACAAGTCCCTGGAGGCCGAGGCCCTGGCAGAAGACATCGAGAAGACCATGAGCACGGCTCTGCACGAGTTG CGGGAACTCGAGAGGCAGAACACGGTCAAGCAGGCGCCAGATGTGGTGCTGGACACCCTGGAGCCCCTGAAGAACCCGCCAGGCCCCGTC AGCTCGGAGCCCGCCAGTCCCCTTCACACCATCGTCATCCGCGACCCCGATGCCGCCATGCGCCGCAGCAGCAGCTCCTCCACCGAGATG ATGACCACCTTCAAGCCAGCCCTGTCCGCCCGCCTGGCTGGCGCCCAGCTCCGCCCGCCCCCCATGCGGCCCGTGCGGCCGGTGGTCCAG CACCGGTCCAGCAGCAGCAGCAGCTCGGGCGTGGGCAGCCCGGCCGTGACGCCCACCGAGAAGATGTTCCCCAACAGCTCAGCGGACAAG TCGGGCACCATGTGACCTGCAGGATGGGCCGCGCCGCCGTGGCCCGCTGTGGCTCACCACGGCCCAGGGTGGCCTTGGTGGCTTCCACGT GCTTCCCAGTGACCCTGGCCTTGGAGGGCAGAGGTCCGTCTGGGAGGGTGTGTCTGTGCAGAGCTGAGGCCCGGGCGCTGGCTGCAGCTC ACGTCCAGCCATGGGAATCCCACGGACCTCTCGCGTGTCAACAGACGACCAGAGGAGTGCTGGAGCTCCAGCAGCCCCAACCACAGCATT CCCTAACATGGAGGCAAAATACCACATGGCTTCTCCCGCATATCGTCACTGGAAACTTCCTCTCTCGACATTCTCTCTACATACGTATAT GTGTGTGTATATCGATGTGTGCATATATACACATGTATACGTATGTACGTGTCTGTAGGTGTGTGTATATATATATATATTTATGCATCT ATATACATATACTAGATCTGGACACACGCATACTAAGTGTATATAGTATCTCCTTTTTCTTTTTATGAAACTTAGATTTACCTCAGATCC ATGCCACCAAACATCTCCCACCGAGTTATTTGGTGGGATTTGCAGGGACTTTTCTGGGAGAACTTAAAGGCCCATAGTAACTGCGAATGA AGCAATATACCACTAACCTGCAGAAAAACACAAACAAAAACAGACTCCCACTGTCTCCAGAAGTCGTGGCCTTCCAGAACAGTCTGCCCC TCAAGGAAGGGTGGGGCAGGCAGTACCCCCAAGCAGGCTGCTCCCAGAGGTGGGGAACCCTTCATAGGAAATCCCCACCCCCGTCCACCC CAGAGACCCTGCCCTTCCACCCGGAGGCCAAAGGCCAACTGTACTCCCAAAGGCATGGGAGAAGGTTGGCGAGAAGACCCCTGACTACCA CATCCTTGTGTTTGTGTGTAGAGACGGGGGATAGTGAGAACCTAAGCCCCATCGTAGCACAGTATTACATGTGGTTGGGAAAAATAAAAA TACAGTGGTGTGGAATACTCCAAAACCTAGAAATGCTGTAGGAATAAATCTGTGGTAACTATAGAGGTTTAACTTATATCATTTTCAAAC TATTTAATTTTTTCTTTTCCTGGTTCTACTAATTATACTGTGTCAGATTTGGAACTAAACAGGCAAGGAGGCTTTGAGTCACATCGTTTT CATTTTAAATCAGGCTGTGATGCACTGTGGCTGGTGCCGTCTTGCATGAAACGCATGAGCCGTGAGCGCCCAGTTCAGACTGGGGCCAGG GAGGGGCAGTCCTTGGCACTTTCTGTCCTAGAGGACACTGTCAGTTGAGTTAATACAAGTGACATAGCTTCCCTTCCCTCCCCCTTCACC CACTCCCTCCAGAACATTTAGTGTAGATGAAAATGTGGTGATAGAAATGGGTGCATGATCTTCACGTGTGACAGCCAGGCCTTTGCCTCT TGGCCAAGTAAAGCCCTTCCGGGTCGCTCTCCTTCGATTCCATTTTACCTCCTCTTCTGATCACTTCCAGAGATGAGCTGTTTCTGGATA ATGGCACACGGGCAAATCTGTGTGCCCTGTGGGCCGCTGTTACTTACCCTCTCCTGCGAGACCCAGGGGCTTTTCCCTACTGTTCCCACG CTTCCTCTCTCTCGAGGCCACTGAAGTTTGGAGTCAAAAGGCCCAGAGTCTGAGTCCCAGCCCTGAGCACTTAGGAGCCTTCTGACTTAG GGTTTGTCACTCCACCTCATTGAGCCTGACTGTTCTGCTCCATAAAATAGGGTAATAAAGGTCAAACATCAGTGAGCAAGCTGTGTACAC TGGAAAACACTGAATCAATACAATGCGTTTGTGATTATCATTAGTAAGGTAAGTCTTAGATCAGAGCCCTCCAGCCCTTCTTTTTGAAAC CTCCCAATGGCATTTCAGAAGTGAGCAGTGGAATTTTCCTGCCATCCTAATAAGAGCCCTGGATTCCATCATTAACATTTCAGCCCATTG GATGAAGTGGTGCCCTCTCCTCTGGTCCCCCGCGAAAAGGTAAATACACCCAAAGGGAGGGACCTAGTTAAGTCACTGGCACCTAGATAA GTTAGGAGGGTAAAGCCACTACCTCGTCTGAAGGACTGGACTTGACACCCCACAGTGGAAGGGAGCATCAGGAGAGGAACAAAAAAAGGG ATCTCAGGGAGAGGCCAGTGTCAAACTTGACCTCCCTTGTTTGGCCTAGAATGAACCCTTCTCTTTAGCTCCTGGATATGAAAGGCCATC TGCTTGGAGCACAGAAAGATATTGCCATTTTACAGCTTAAGAGAGTAAGGCCTTGGGCTGTGCTGTGACCTGCCCAAGATTTGACACTGG CTAGGAGCAGAGGCTGCGTCAGGCTCTTAAAGTCATGTGTTTGCATGCTGGATGCTATACTGTCCAGCCAGGACACAAGACTTCTGATTT CTACCCTCAAGATACTCCCAGATCCTAAATCCAGTAGCCTCCCAGGCAAAATATAGCAATCTGCCACAACTGCCAGATGAAAAGCAACAA TCAGAGTAGAAAAATCTGTTGCCTGATATACATAACACCAATCAGACCGTGTGGATTTTTCTCTGAATTGACTGATTTTGTTTTTTTCTT ACTGAAAATGGACCTGCCTTTCACTGAATTTTCTGAGGGCAGAGTCTTAGCTGTTTTCTTTAAGCACCTTTTTTTTTTTTTTCCATTGGG AAATGGCTGATGAGTTCACATTTAGGGATGTACACACACAGATGGCAGACGTCTCCCCACTCATCCAGCCCCAGATCTGAGCCTTGACGC AGGCCAAGTGGAAAAATACTTTCCCGCCCCCCTCCCCTGTTCCCACTTCCTCATCTGGCACTATGCATGTCTCACTCACCCTCCACAGCA CTCAGTCCCATCGACGTTCACTGAACATTGGCTTTCTCTTTCTGACTCCTGCCTGTTTTAGTCCACTATATATTGCTGTATTTGCTTAAA TGCTGGAAAGTAACTGTTAAAATGTGAAATTGTAATTTTTAAAAAGGCTACAATTAAATTTTAGCCAATGCCACTCACCAAATCTTTGCA CCTAGTAGATAGATCAATGTAAAAACAAATACCTAACTGTACAGTGAGTGTGGGGGAAATGTAGTAACCTAGTTAGTAGTCTTCAATATA ACCAATTGTACAAGGGGAAGTGGTGTTTACCTACTTGTTCATCACCATTATTGAAAGCCGTACTGATCAGTTAGTTGACAACGGGCATTT TTTTTTCTTTGCTTCATGGAATGATTTCTTTTCTTAACCTTCGACTTATCCTGAGGTCAAGCCTTTTGTCTTTATGTGTAACCGACGTTC AGTCTATTCTAGGAATGAACCAGCAAGTTGTTCATTTAAAACTGACCAAAGACAATTAATTCCTGGTCTAGTTTCCTGGGCCTTGTGGCT CAGCTGCCACTAAAGAGCTTTTTGGATAAAATTGAGAACAAGCTGTGCTTCCTACCCCACTCTCCCCGTCCCCTTTTATTCCCTTTTCCT CTTAAAGAGCTGCTCTGAGCTGTGGGATTCTATGAAAAATTCTTGCCTTTCCTTGTTTCAGTGCTAACGATTTCTCACCTCGAAGCGCCT TTTGAACCCCGGACAGAGTGCACAATCGGAGGGAATTGCGAGCTTGGGAATTAGACTTTGGAGTCTTTTCTCTGAAGTCACCAGGCCAGG GGTCAGGAGAGAGATGGATTCCCAAGGGATGAAAGGTTTCTATTCAATGAAGAAATCGGAGTGGGAAGAGACACAGGGAAATTGAGCCAT ATTTTGGCTATCGGCTGGAACCAGCAGTTCAGAGATCTGCCTTATAAACATTTAAAACCGGTTTGTGGTACACAAAGAGGAACCAGTGTG GGAAGGGGCCTTTATGTGGGGCTTTCTTCTCTGTTGGAGTCCCTTGGAGTGCCTTGTTGGGTATATTTCTCTGTCATTCAGGAGGCACGA ATGTGGAGGACTTCTCGTGACCTGGTCGTGATGTGGCATTCAGTGCATGTCCACAGCTAATGGAAAAACACGAGGACTCGGGTAATGGTT CTTCCTCTCAGTCTTTCTATTCCTAACTTTTCACACATCCAGATGGTTCCACACTAGTGCAAATGCCTCACTCTCCTGAGAAACCCAGAA AGAAGAGTGGCTGGCTCACAACCATGGGGTTAGCCCCTGCTGGGCTGGGAGTCGGGGTGGCGGCCAGGAGGAAAGGCAGAAAGGGGTGAG CCGAGGTGTTGCCTAGCTGATTTTCTGCTGTGCAGAGCTAATGCTGACATTTCATGTCAACTTCCCCGGTTCTCTGGGGTCTCCTCTCCT CTGAGCAGCCACATAGAACATTCCCCACATATCCAAAGCTGCCCAGGGGAGCCGAGAGAAGGGACTTTGCTGTCAGGTCCAAGCCCTCCT GACCTCCCTGAGATTGATCTGCCAGTGTCCTGCTGTCCCTCTGGGACTGGCCACATGGCCATCGCTGCCCCTTGTTGACACCTCCTTTCT GTGTGAGTTGTCCCCGGCCAATAACAAAGCTGTTCCTTGAACCAGAACAACCAGAGTGCACTTTTCCTTCCTTAGACGGAAGTAGATCCT GGCTAGGGTTTCTGCCCAGGCCCTTGTTCCCGGCAGTGTGACTGTTTACATGGTTTGGCAATAGGTTTGATTCTGATTGCTTCAGAGTGG CTGGTCTATTTTGTTTCCTTTGGTTTCCTTCCTCCCCAAATTGTGACAGGAAAAACAGACCAAAACCACCCTAGGAAATTGCTGGTTGCC TGTCCCCACGTGATGATAAATGTTGCCCTCTTCTGGATATCGTTTCTCTACCTTACGACCAAACGCCCGTCCTATAGAGTGTCTGATTGG >40216_40216_1_IRAK2-SRGAP3_IRAK2_chr3_10206732_ENST00000256458_SRGAP3_chr3_9166601_ENST00000360413_length(amino acids)=1084AA_BP=31 MACYIYQLPSWVLDDLCRNMDALSEWDWMEFEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYH AESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHD VSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPV QTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFT KFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRGRRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKN SFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYS DENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGT EPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLL DDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMA TFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPV SSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADK -------------------------------------------------------------- >40216_40216_2_IRAK2-SRGAP3_IRAK2_chr3_10206732_ENST00000256458_SRGAP3_chr3_9166601_ENST00000383836_length(transcript)=8345nt_BP=184nt TTCCCCGCCGGTCCGCCCCTGGCTAGAGAAGCCGCAGCCCGCAGTGTCCGACCCAGTCGTCCCGCGCCGGAGCCGGCCCCGTAGCGTGCC ATGGCCTGCTACATCTACCAGCTGCCCTCCTGGGTGCTGGACGACCTGTGCCGCAACATGGACGCGCTCAGCGAGTGGGACTGGATGGAG TTCGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGCAATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAG TTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGGAGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCC CGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACTGTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGA GACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCCTCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAG AGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCAATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCAT GCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGGAGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAAC CTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGATTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAG AACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGGCAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGAT GTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGGCCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTG GAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACAACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATG TGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACATGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTC CAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCACCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGAT GCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATGTCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTC AAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGAGGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACA AAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGGCCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAA AGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCACAGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCAT AAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGGATTCAGGACAAGCTATACCGCTTGTAGTCGAGAGCTGCATCCGTTACATCAAT TTATATGGACTCCAGCAGCAGGGGATCTTCAGAGTGCCAGGATCTCAGGTGGAAGTCAATGACATCAAAAATTCCTTTGAGAGAGGTGAA GACCCCCTTGTGGACGATCAAAATGAACGAGATATCAATTCAGTCGCTGGTGTTTTAAAACTGTATTTCCGAGGACTGGAAAACCCACTC TTTCCTAAGGAAAGGTTTCAAGATTTGATATCTACTATTAAACTGGAGAACCCAGCCGAGAGGGTGCACCAGATCCAACAAATCCTCGTC ACCCTTCCCCGCGTGGTCATTGTGGTCATGAGATACCTCTTCGCTTTCCTCAACCACCTCTCCCAGTATAGCGACGAGAACATGATGGAT CCCTACAACCTGGCCATCTGCTTCGGGCCTACCCTCATGCACATCCCTGATGGGCAGGACCCTGTGTCCTGCCAGGCACACATCAATGAA GTCATCAAAACCATCATCATCCATCATGAAGCCATCTTCCCCAGCCCCCGGGAGCTAGAGGGACCTGTGTATGAAAAATGCATGGCTGGA GGGGAAGAATATTGTGACAGCCCACACAGCGAGCCAGGGGCCATCGATGAAGTTGACCATGACAATGGCACTGAGCCTCATACCAGCGAT GAAGAAGTGGAGCAGATCGAGGCTATTGCCAAGTTTGACTACATGGGGCGGTCCCCGCGTGAGCTATCCTTCAAGAAGGGGGCCTCGCTG CTCCTGTACCACCGCGCCTCGGAGGACTGGTGGGAGGGCCGGCACAACGGCGTGGATGGACTCATCCCCCATCAGTACATAGTTGTACAG GACATGGATGATGCCTTCTCCGACAGCCTGAGCCAGAAGGCTGACAGCGAGGCCAGCAGTGGGCCATTGCTGGATGACAAGGCCTCTTCC AAAAACGACCTCCAGTCCCCCACGGAGCACATCTCGGATTACGGCTTTGGGGGGGTGATGGGCCGAGTGCGGTTACGATCTGATGGAGCA GCCATCCCCAGACGCCGAAGCGGGGGCGACACACACAGCCCGCCCCGGGGCCTGGGCCCCAGCATAGACACACCACCCCGGGCTGCTGCC TGCCCCAGCAGCCCCCACAAAATCCCCCTCACCCGGGGGAGGATCGAGAGCCCTGAGAAGCGGAGGATGGCGACGTTCGGGAGCGCTGGC AGCATCAACTACCCTGACAAGAAGGCGCTCTCCGAAGGGCACTCGATGAGGTCGACCTGCGGTTCCACCAGGCACAGCAGCCTAGGGGAC CACAAGTCCCTGGAGGCCGAGGCCCTGGCAGAAGACATCGAGAAGACCATGAGCACGGCTCTGCACGAGTTGCGGGAACTCGAGAGGCAG AACACGGTCAAGCAGGCGCCAGATGTGGTGCTGGACACCCTGGAGCCCCTGAAGAACCCGCCAGGCCCCGTCAGCTCGGAGCCCGCCAGT CCCCTTCACACCATCGTCATCCGCGACCCCGATGCCGCCATGCGCCGCAGCAGCAGCTCCTCCACCGAGATGATGACCACCTTCAAGCCA GCCCTGTCCGCCCGCCTGGCTGGCGCCCAGCTCCGCCCGCCCCCCATGCGGCCCGTGCGGCCGGTGGTCCAGCACCGGTCCAGCAGCAGC AGCAGCTCGGGCGTGGGCAGCCCGGCCGTGACGCCCACCGAGAAGATGTTCCCCAACAGCTCAGCGGACAAGTCGGGCACCATGTGACCT GCAGGATGGGCCGCGCCGCCGTGGCCCGCTGTGGCTCACCACGGCCCAGGGTGGCCTTGGTGGCTTCCACGTGCTTCCCAGTGACCCTGG CCTTGGAGGGCAGAGGTCCGTCTGGGAGGGTGTGTCTGTGCAGAGCTGAGGCCCGGGCGCTGGCTGCAGCTCACGTCCAGCCATGGGAAT CCCACGGACCTCTCGCGTGTCAACAGACGACCAGAGGAGTGCTGGAGCTCCAGCAGCCCCAACCACAGCATTCCCTAACATGGAGGCAAA ATACCACATGGCTTCTCCCGCATATCGTCACTGGAAACTTCCTCTCTCGACATTCTCTCTACATACGTATATGTGTGTGTATATCGATGT GTGCATATATACACATGTATACGTATGTACGTGTCTGTAGGTGTGTGTATATATATATATATTTATGCATCTATATACATATACTAGATC TGGACACACGCATACTAAGTGTATATAGTATCTCCTTTTTCTTTTTATGAAACTTAGATTTACCTCAGATCCATGCCACCAAACATCTCC CACCGAGTTATTTGGTGGGATTTGCAGGGACTTTTCTGGGAGAACTTAAAGGCCCATAGTAACTGCGAATGAAGCAATATACCACTAACC TGCAGAAAAACACAAACAAAAACAGACTCCCACTGTCTCCAGAAGTCGTGGCCTTCCAGAACAGTCTGCCCCTCAAGGAAGGGTGGGGCA GGCAGTACCCCCAAGCAGGCTGCTCCCAGAGGTGGGGAACCCTTCATAGGAAATCCCCACCCCCGTCCACCCCAGAGACCCTGCCCTTCC ACCCGGAGGCCAAAGGCCAACTGTACTCCCAAAGGCATGGGAGAAGGTTGGCGAGAAGACCCCTGACTACCACATCCTTGTGTTTGTGTG TAGAGACGGGGGATAGTGAGAACCTAAGCCCCATCGTAGCACAGTATTACATGTGGTTGGGAAAAATAAAAATACAGTGGTGTGGAATAC TCCAAAACCTAGAAATGCTGTAGGAATAAATCTGTGGTAACTATAGAGGTTTAACTTATATCATTTTCAAACTATTTAATTTTTTCTTTT CCTGGTTCTACTAATTATACTGTGTCAGATTTGGAACTAAACAGGCAAGGAGGCTTTGAGTCACATCGTTTTCATTTTAAATCAGGCTGT GATGCACTGTGGCTGGTGCCGTCTTGCATGAAACGCATGAGCCGTGAGCGCCCAGTTCAGACTGGGGCCAGGGAGGGGCAGTCCTTGGCA CTTTCTGTCCTAGAGGACACTGTCAGTTGAGTTAATACAAGTGACATAGCTTCCCTTCCCTCCCCCTTCACCCACTCCCTCCAGAACATT TAGTGTAGATGAAAATGTGGTGATAGAAATGGGTGCATGATCTTCACGTGTGACAGCCAGGCCTTTGCCTCTTGGCCAAGTAAAGCCCTT CCGGGTCGCTCTCCTTCGATTCCATTTTACCTCCTCTTCTGATCACTTCCAGAGATGAGCTGTTTCTGGATAATGGCACACGGGCAAATC TGTGTGCCCTGTGGGCCGCTGTTACTTACCCTCTCCTGCGAGACCCAGGGGCTTTTCCCTACTGTTCCCACGCTTCCTCTCTCTCGAGGC CACTGAAGTTTGGAGTCAAAAGGCCCAGAGTCTGAGTCCCAGCCCTGAGCACTTAGGAGCCTTCTGACTTAGGGTTTGTCACTCCACCTC ATTGAGCCTGACTGTTCTGCTCCATAAAATAGGGTAATAAAGGTCAAACATCAGTGAGCAAGCTGTGTACACTGGAAAACACTGAATCAA TACAATGCGTTTGTGATTATCATTAGTAAGGTAAGTCTTAGATCAGAGCCCTCCAGCCCTTCTTTTTGAAACCTCCCAATGGCATTTCAG AAGTGAGCAGTGGAATTTTCCTGCCATCCTAATAAGAGCCCTGGATTCCATCATTAACATTTCAGCCCATTGGATGAAGTGGTGCCCTCT CCTCTGGTCCCCCGCGAAAAGGTAAATACACCCAAAGGGAGGGACCTAGTTAAGTCACTGGCACCTAGATAAGTTAGGAGGGTAAAGCCA CTACCTCGTCTGAAGGACTGGACTTGACACCCCACAGTGGAAGGGAGCATCAGGAGAGGAACAAAAAAAGGGATCTCAGGGAGAGGCCAG TGTCAAACTTGACCTCCCTTGTTTGGCCTAGAATGAACCCTTCTCTTTAGCTCCTGGATATGAAAGGCCATCTGCTTGGAGCACAGAAAG ATATTGCCATTTTACAGCTTAAGAGAGTAAGGCCTTGGGCTGTGCTGTGACCTGCCCAAGATTTGACACTGGCTAGGAGCAGAGGCTGCG TCAGGCTCTTAAAGTCATGTGTTTGCATGCTGGATGCTATACTGTCCAGCCAGGACACAAGACTTCTGATTTCTACCCTCAAGATACTCC CAGATCCTAAATCCAGTAGCCTCCCAGGCAAAATATAGCAATCTGCCACAACTGCCAGATGAAAAGCAACAATCAGAGTAGAAAAATCTG TTGCCTGATATACATAACACCAATCAGACCGTGTGGATTTTTCTCTGAATTGACTGATTTTGTTTTTTTCTTACTGAAAATGGACCTGCC TTTCACTGAATTTTCTGAGGGCAGAGTCTTAGCTGTTTTCTTTAAGCACCTTTTTTTTTTTTTTCCATTGGGAAATGGCTGATGAGTTCA CATTTAGGGATGTACACACACAGATGGCAGACGTCTCCCCACTCATCCAGCCCCAGATCTGAGCCTTGACGCAGGCCAAGTGGAAAAATA CTTTCCCGCCCCCCTCCCCTGTTCCCACTTCCTCATCTGGCACTATGCATGTCTCACTCACCCTCCACAGCACTCAGTCCCATCGACGTT CACTGAACATTGGCTTTCTCTTTCTGACTCCTGCCTGTTTTAGTCCACTATATATTGCTGTATTTGCTTAAATGCTGGAAAGTAACTGTT AAAATGTGAAATTGTAATTTTTAAAAAGGCTACAATTAAATTTTAGCCAATGCCACTCACCAAATCTTTGCACCTAGTAGATAGATCAAT GTAAAAACAAATACCTAACTGTACAGTGAGTGTGGGGGAAATGTAGTAACCTAGTTAGTAGTCTTCAATATAACCAATTGTACAAGGGGA AGTGGTGTTTACCTACTTGTTCATCACCATTATTGAAAGCCGTACTGATCAGTTAGTTGACAACGGGCATTTTTTTTTCTTTGCTTCATG GAATGATTTCTTTTCTTAACCTTCGACTTATCCTGAGGTCAAGCCTTTTGTCTTTATGTGTAACCGACGTTCAGTCTATTCTAGGAATGA ACCAGCAAGTTGTTCATTTAAAACTGACCAAAGACAATTAATTCCTGGTCTAGTTTCCTGGGCCTTGTGGCTCAGCTGCCACTAAAGAGC TTTTTGGATAAAATTGAGAACAAGCTGTGCTTCCTACCCCACTCTCCCCGTCCCCTTTTATTCCCTTTTCCTCTTAAAGAGCTGCTCTGA GCTGTGGGATTCTATGAAAAATTCTTGCCTTTCCTTGTTTCAGTGCTAACGATTTCTCACCTCGAAGCGCCTTTTGAACCCCGGACAGAG TGCACAATCGGAGGGAATTGCGAGCTTGGGAATTAGACTTTGGAGTCTTTTCTCTGAAGTCACCAGGCCAGGGGTCAGGAGAGAGATGGA TTCCCAAGGGATGAAAGGTTTCTATTCAATGAAGAAATCGGAGTGGGAAGAGACACAGGGAAATTGAGCCATATTTTGGCTATCGGCTGG AACCAGCAGTTCAGAGATCTGCCTTATAAACATTTAAAACCGGTTTGTGGTACACAAAGAGGAACCAGTGTGGGAAGGGGCCTTTATGTG GGGCTTTCTTCTCTGTTGGAGTCCCTTGGAGTGCCTTGTTGGGTATATTTCTCTGTCATTCAGGAGGCACGAATGTGGAGGACTTCTCGT GACCTGGTCGTGATGTGGCATTCAGTGCATGTCCACAGCTAATGGAAAAACACGAGGACTCGGGTAATGGTTCTTCCTCTCAGTCTTTCT ATTCCTAACTTTTCACACATCCAGATGGTTCCACACTAGTGCAAATGCCTCACTCTCCTGAGAAACCCAGAAAGAAGAGTGGCTGGCTCA CAACCATGGGGTTAGCCCCTGCTGGGCTGGGAGTCGGGGTGGCGGCCAGGAGGAAAGGCAGAAAGGGGTGAGCCGAGGTGTTGCCTAGCT GATTTTCTGCTGTGCAGAGCTAATGCTGACATTTCATGTCAACTTCCCCGGTTCTCTGGGGTCTCCTCTCCTCTGAGCAGCCACATAGAA CATTCCCCACATATCCAAAGCTGCCCAGGGGAGCCGAGAGAAGGGACTTTGCTGTCAGGTCCAAGCCCTCCTGACCTCCCTGAGATTGAT CTGCCAGTGTCCTGCTGTCCCTCTGGGACTGGCCACATGGCCATCGCTGCCCCTTGTTGACACCTCCTTTCTGTGTGAGTTGTCCCCGGC CAATAACAAAGCTGTTCCTTGAACCAGAACAACCAGAGTGCACTTTTCCTTCCTTAGACGGAAGTAGATCCTGGCTAGGGTTTCTGCCCA GGCCCTTGTTCCCGGCAGTGTGACTGTTTACATGGTTTGGCAATAGGTTTGATTCTGATTGCTTCAGAGTGGCTGGTCTATTTTGTTTCC TTTGGTTTCCTTCCTCCCCAAATTGTGACAGGAAAAACAGACCAAAACCACCCTAGGAAATTGCTGGTTGCCTGTCCCCACGTGATGATA AATGTTGCCCTCTTCTGGATATCGTTTCTCTACCTTACGACCAAACGCCCGTCCTATAGAGTGTCTGATTGGATCCTCTGTCGCGTATTC >40216_40216_2_IRAK2-SRGAP3_IRAK2_chr3_10206732_ENST00000256458_SRGAP3_chr3_9166601_ENST00000383836_length(amino acids)=1108AA_BP=31 MACYIYQLPSWVLDDLCRNMDALSEWDWMEFEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYH AESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHD VSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPV QTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFT KFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYIN LYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILV TLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAG GEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQ DMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAA CPSSPHKIPLTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQ NTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for IRAK2-SRGAP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IRAK2-SRGAP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IRAK2-SRGAP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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