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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IRF1-PCDHA8 (FusionGDB2 ID:40236)

Fusion Gene Summary for IRF1-PCDHA8

Fusion gene summary

Fusion gene information	Fusion gene name: IRF1-PCDHA8
	Fusion gene ID: 40236
		Hgene	Tgene
	Gene symbol	IRF1	PCDHA8
	Gene ID	3659	56140
	Gene name	interferon regulatory factor 1	protocadherin alpha 8
	Synonyms	IRF-1\|MAR	PCDH-ALPHA8
	Cytomap	5q31.1	5q31.3
	Type of gene	protein-coding	protein-coding
	Description	interferon regulatory factor 1interferon regulatory factor 1 isoform +I9interferon regulatory factor 1 isoform d78interferon regulatory factor 1 isoform d9,10+interferon regulatory factor 1 isoform delta4interferon regulatory factor 1 isoform delta7	protocadherin alpha-8KIAA0345-like 6PCDH-alpha-8
	Modification date	20200315	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000245414, ENST00000405885, ENST00000463784,	ENST00000378123, ENST00000531613,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 3 X 4=60
	# samples	3	5
	** MAII score	log2(3/8*10)=1.90689059560852	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IRF1 [Title/Abstract] AND PCDHA8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IRF1(131822248)-PCDHA8(140389211), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IRF1	GO:0006915	apoptotic process	19851330
Hgene	IRF1	GO:0007050	cell cycle arrest	22200613
Hgene	IRF1	GO:0035458	cellular response to interferon-beta	18035482
Hgene	IRF1	GO:0045893	positive regulation of transcription, DNA-templated	22200613
Hgene	IRF1	GO:0051607	defense response to virus	21389130\|21478870

Fusion gene breakpoints across IRF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCDHA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-56-7222-11A	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+

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Fusion Gene ORF analysis for IRF1-PCDHA8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000245414	ENST00000378123	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+
5CDS-intron	ENST00000405885	ENST00000378123	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+
In-frame	ENST00000245414	ENST00000531613	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+
In-frame	ENST00000405885	ENST00000531613	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+
intron-3CDS	ENST00000463784	ENST00000531613	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+
intron-intron	ENST00000463784	ENST00000378123	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000245414

IRF1

chr5

131822248

ENST00000531613

PCDHA8

chr5

140389211

3521

803

193

1113

306

ENST00000405885

IRF1

chr5

131822248

ENST00000531613

PCDHA8

chr5

140389211

3480

762

218

1072

284

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000245414	ENST00000531613	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+	0.001950681	0.9980494
ENST00000405885	ENST00000531613	IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+	0.001735859	0.99826413

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Fusion Genomic Features for IRF1-PCDHA8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+	0.13290016	0.8670998
IRF1	chr5	131822248	-	PCDHA8	chr5	140389211	+	0.13290016	0.8670998

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IRF1-PCDHA8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131822248/chr5:140389211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IRF1

chr5:131822248

chr5:140389211

ENST00000245414

5_113

181

326.0

DNA binding

IRF tryptophan pentad repeat

Hgene

IRF1

chr5:131822248

chr5:140389211

ENST00000405885

5_113

181

326.0

DNA binding

IRF tryptophan pentad repeat

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

923_930

815.0

Compositional bias

Note=Poly-Lys

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

923_930

847

951.0

Compositional bias

Note=Poly-Lys

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

157_242

815.0

Domain

Cadherin 2

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

243_350

815.0

Domain

Cadherin 3

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

30_133

815.0

Domain

Cadherin 1

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

351_455

815.0

Domain

Cadherin 4

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

456_565

815.0

Domain

Cadherin 5

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

581_678

815.0

Domain

Cadherin 6

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

774_894

815.0

Region

Note=5 X 4 AA repeats of P-X-X-P

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

774_777

815.0

Repeat

Note=PXXP 1

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

799_802

815.0

Repeat

Note=PXXP 2

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

832_835

815.0

Repeat

Note=PXXP 3

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

873_876

815.0

Repeat

Note=PXXP 4

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

891_894

815.0

Repeat

Note=PXXP 5

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

873_876

847

951.0

Repeat

Note=PXXP 4

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

891_894

847

951.0

Repeat

Note=PXXP 5

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

30_697

815.0

Topological domain

Extracellular

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

719_950

815.0

Topological domain

Cytoplasmic

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000378123

698_718

815.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

157_242

847

951.0

Domain

Cadherin 2

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

243_350

847

951.0

Domain

Cadherin 3

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

30_133

847

951.0

Domain

Cadherin 1

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

351_455

847

951.0

Domain

Cadherin 4

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

456_565

847

951.0

Domain

Cadherin 5

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

581_678

847

951.0

Domain

Cadherin 6

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

774_894

847

951.0

Region

Note=5 X 4 AA repeats of P-X-X-P

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

774_777

847

951.0

Repeat

Note=PXXP 1

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

799_802

847

951.0

Repeat

Note=PXXP 2

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

832_835

847

951.0

Repeat

Note=PXXP 3

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

30_697

847

951.0

Topological domain

Extracellular

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

719_950

847

951.0

Topological domain

Cytoplasmic

Tgene

PCDHA8

chr5:131822248

chr5:140389211

ENST00000531613

698_718

847

951.0

Transmembrane

Helical

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Fusion Gene Sequence for IRF1-PCDHA8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40236_40236_1_IRF1-PCDHA8_IRF1_chr5_131822248_ENST00000245414_PCDHA8_chr5_140389211_ENST00000531613_length(transcript)=3521nt_BP=803nt
TGCTCGGTGGCGCCGCTGCCCTGGCAGAGCTCGCCACTCCTTAGTCGAGGCAAGACGTGCGCCCGAGCCCCGCCGAACCGAGGCCACCCG
GAGCCGTGCCCAGTCCACGCCGGCCGTGCCCGGCGGCCTTAAGAACCCGGCAACCTCTGCCTTCTTCCCTCTTCCACTCGGAGTCGCGCT
CCGCGCGCCCTCACTGCAGCCCCTGCGTCGCCGGGACCCTCGCGCGCGACCGCCGAATCGCTCCTGCAGCAGAGCCAACATGCCCATCAC
TCGGATGCGCATGAGACCCTGGCTAGAGATGCAGATTAATTCCAACCAAATCCCGGGGCTCATCTGGATTAATAAAGAGGAGATGATCTT
CCAGATCCCATGGAAGCATGCTGCCAAGCATGGCTGGGACATCAACAAGGATGCCTGTTTGTTCCGGAGCTGGGCCATTCACACAGGCCG
ATACAAAGCAGGGGAAAAGGAGCCAGATCCCAAGACGTGGAAGGCCAACTTTCGCTGTGCCATGAACTCCCTGCCAGATATCGAGGAGGT
GAAAGACCAGAGCAGGAACAAGGGCAGCTCAGCTGTGCGAGTGTACCGGATGCTTCCACCTCTCACCAAGAACCAGAGAAAAGAAAGAAA
GTCGAAGTCCAGCCGAGATGCTAAGAGCAAGGCCAAGAGGAAGTCATGTGGGGATTCCAGCCCTGATACCTTCTCTGATGGACTCAGCAG
CTCCACTCTGCCTGATGACCACAGCAGCTACACAGTTCCAGGCTACATGCAGGACTTGGAGGTGGAGCAGGCCCTGACTCCAGAACCAGA
GGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGG
TCCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGACAA
AAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAA
AGGGAACAGCACGACTGACAACAGTGACCAGTGAGGTCCTCAAATGGAAACAAGCCACTTAGCCAGTTTTTGTAATAATGGCAAATCTCT
CCCATGTAGCAATTCCCTGCTCCTTTTTCCTATCTACATGAGCCCTCTTAGAGACCTCAGAAATCTGCAGAAAGTTCCCTGTGTCTGTCT
AGAACGCATTTAACAGGTTTTGTCGTAAAAGCTTTACTAAGTCTGGTGTTAACTCTTTCTCTCCACTCTGGCTTGTTTTCAGAACCTAAA
AAGCAGACCCAAGTTTCCTTTCTCCTCCGCCGCAAAGGAGAGGCTTCCCAGCCCCGCCAGTGAGAGGTTGGACTCTCTGCCCTGTGCTCC
GGGGATCCTGTCTTGATGACACTTGCAGGGCAGGCTGAAAAGTTTTGAGATTGAGCAGCTTGGGAGTTTGTGGCCACTGGGTATGTGTGG
CTACCGCGGGTATGCGAGTGCCAGATATTGGCTGAGACGAGCCAGCTTAGACTAATTGGTACAAGGAAGGCAAGAAAACAAAGACAAATA
AACAGCGGAAGTTATCAGTATGGAGGGGAAGTGTAAACTTAAAGGGACCAGACTTTCTAAATCTTACAACTCAAGAGGTGGCAGCCACCC
TCTAGGAGACAAAACTACCCCCACTGACAAGGCTTTAGGAGACCCTAAAGTCTGTTGGCTGTGACGTCATTATACCTAAAATCTGCATCA
TACCTGCAAGCCAACAGTTCAGTGTTTTAACAGAGAACCACCCTGGGAAACAGAAGCAGATCTGATGTGTTTCCTATACATGTCCTGTGC
TCACTTTATTAAAAATTCTTTTGCACACAATGTTTATGAAAAGGCCAGATCCTTTTCCAATACTTATGCAAAAGCAAAAGAAAACCCCGA
CACCTCACCTTTCGCTGTTTGTTGTTTCATAGATTTATTTAAAAAAAGAGAAAGTCTATAGCTATAAATCTTTAAAGAGAAATATGAATA
CAATTCCCCTAAACTCTCCTCAAAAGAGAATTCAGTCTACAGCCATTTAAATGATCATTGCTGCTACAGAAGTGCTTTAAGAGAATTGCC
TGAAACATCTGTATTATATCGGCCACCTGCCAATCACAGCTTTACTCTTTCAGGTCACTCTGGGGCTGCCTCTTGCATGTATTACTAAAT
AAAATGATCTCTCTTTCTCTCTCTCTCTCTCTTTTCTAAGAAACAATTATGTGCACTTTGATACACAACCTTCTCTAACCAACTATATAT
CAAGACCCAAAAATTGAAGAAAAATATTGTTTTCTCATACAGTGAGCAGATTTTTCAATCTACTAATTCTGTGACTTGTCTTGGTGTGCT
AGCCTACACCTTCTCTTTGGTTTAGTTTTCCTTTTCTATAACACTCTGAATTGCTAATCTTACTAACACCTATGATGTTACCTGAAATCA
ATCTCCCATATGTATGCTGTATGCTATGCTAAGACTCCTGAAATATACTTACTCTGTGCTTGTGTATGTGAATGTTAATGCAACTATTAC
CTAGAGTGAACTTTAAGCTTTATTGTTGAATGTAATTCCATTATATTTCCTTTTGTACACCTGTGAAAAAGTGGAGTAGTGTTTTTTTAA
CCATTGTTAATCAGCTTTTGTGTATGAAAGACACAGTAAAATTTCTTTCTTAAATCAAGATACTGGTGATTCAAGGAATTTTATTTATGG
TCCAGCCAAGAGCCATCTCGTGCCAAGACTTCTGCTGGCAAGGGAATGGATAAAGCTGTTTTGTTCTAGTAACAATTTTGGAATGAATAC
TGACAATATTCCATGAGGGTGTGCAAGCACAAATTTTACCAATCTGACCTCTTTGAAGTTGCAGAATGCTTTGAAATTCTAATGGTATCT
GAAATATCAGCTCATAGAAAGTAACAAAATTTGCTGTCACCTTAAATAAGACATTTTAATTTTGTTATAATGTACAATTTAGAAGTTTGA
TTAATTATATTATCTATTTAGGCATTAATATAAAAGAGGTAGGAGTCTGTTATTTAAAAAAAGCATTAAATTTAAAAAAAAACTGTCTTG
TCTACTTTTAGCTTCATTCTCCCATATTTTGAAGGGTGTGTAACTTCAGCTCTGCAGGATTGCATGGGGTAAAACTTGTTACCAACACAT
GTGAACCATTGCTACATTGTAGGTTGTGATCATTTTGCCCCACTGAAGCCCATGTATCTGACCTTACGTGCCTTTTGAACTAGGAGAATC
GGGCTAATTTATTAATGATGATAATTATAATGTATCTGTACAGCACTTTTTACATTTGCGAAGTGCTTTCCAATCCATGTTAGTTACTAG
TTATTACAGCTGTAAGGATAAAACACGTCATGTGGATTCATTTTGAATTGGTGCTATTGGTATTTCCTCTGTTATTGCTAATAAATGAAA

>40236_40236_1_IRF1-PCDHA8_IRF1_chr5_131822248_ENST00000245414_PCDHA8_chr5_140389211_ENST00000531613_length(amino acids)=306AA_BP=203
MQPLRRRDPRARPPNRSCSRANMPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAG
EKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLP
DDHSSYTVPGYMQDLEVEQALTPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFI

--------------------------------------------------------------
>40236_40236_2_IRF1-PCDHA8_IRF1_chr5_131822248_ENST00000405885_PCDHA8_chr5_140389211_ENST00000531613_length(transcript)=3480nt_BP=762nt
CCCGCTATGTTCGTCCCGCGCATCCACACGCCGTGCCGGGGACCGAGTGTCAGCCCACGCGTGGGCGCCCAGTGCTCCCGGCTTTCGGCG
GTCCCAGCTCCGCGCCCAGGCGACAGGTTTTGGGCTCCCTGTGCTGGTGGCAAGGGCTGGCTTACTGCCCAGGTGGCTGGAGGGAATCGT
GACCTACGGAGACTGCGGGAAGAGGCGCCACAGCCAACATGCCCATCACTCGGATGCGCATGAGACCCTGGCTAGAGATGCAGATTAATT
CCAACCAAATCCCGGGGCTCATCTGGATTAATAAAGAGGAGATGATCTTCCAGATCCCATGGAAGCATGCTGCCAAGCATGGCTGGGACA
TCAACAAGGATGCCTGTTTGTTCCGGAGCTGGGCCATTCACACAGGCCGATACAAAGCAGGGGAAAAGGAGCCAGATCCCAAGACGTGGA
AGGCCAACTTTCGCTGTGCCATGAACTCCCTGCCAGATATCGAGGAGGTGAAAGACCAGAGCAGGAACAAGGGCAGCTCAGCTGTGCGAG
TGTACCGGATGCTTCCACCTCTCACCAAGAACCAGAGAAAAGAAAGAAAGTCGAAGTCCAGCCGAGATGCTAAGAGCAAGGCCAAGAGGA
AGTCATGTGGGGATTCCAGCCCTGATACCTTCTCTGATGGACTCAGCAGCTCCACTCTGCCTGATGACCACAGCAGCTACACAGTTCCAG
GCTACATGCAGGACTTGGAGGTGGAGCAGGCCCTGACTCCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACA
GCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTC
CTGCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAGA
AAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGCACGACTGACAACAGTGACCAGTGAGGTCCTC
AAATGGAAACAAGCCACTTAGCCAGTTTTTGTAATAATGGCAAATCTCTCCCATGTAGCAATTCCCTGCTCCTTTTTCCTATCTACATGA
GCCCTCTTAGAGACCTCAGAAATCTGCAGAAAGTTCCCTGTGTCTGTCTAGAACGCATTTAACAGGTTTTGTCGTAAAAGCTTTACTAAG
TCTGGTGTTAACTCTTTCTCTCCACTCTGGCTTGTTTTCAGAACCTAAAAAGCAGACCCAAGTTTCCTTTCTCCTCCGCCGCAAAGGAGA
GGCTTCCCAGCCCCGCCAGTGAGAGGTTGGACTCTCTGCCCTGTGCTCCGGGGATCCTGTCTTGATGACACTTGCAGGGCAGGCTGAAAA
GTTTTGAGATTGAGCAGCTTGGGAGTTTGTGGCCACTGGGTATGTGTGGCTACCGCGGGTATGCGAGTGCCAGATATTGGCTGAGACGAG
CCAGCTTAGACTAATTGGTACAAGGAAGGCAAGAAAACAAAGACAAATAAACAGCGGAAGTTATCAGTATGGAGGGGAAGTGTAAACTTA
AAGGGACCAGACTTTCTAAATCTTACAACTCAAGAGGTGGCAGCCACCCTCTAGGAGACAAAACTACCCCCACTGACAAGGCTTTAGGAG
ACCCTAAAGTCTGTTGGCTGTGACGTCATTATACCTAAAATCTGCATCATACCTGCAAGCCAACAGTTCAGTGTTTTAACAGAGAACCAC
CCTGGGAAACAGAAGCAGATCTGATGTGTTTCCTATACATGTCCTGTGCTCACTTTATTAAAAATTCTTTTGCACACAATGTTTATGAAA
AGGCCAGATCCTTTTCCAATACTTATGCAAAAGCAAAAGAAAACCCCGACACCTCACCTTTCGCTGTTTGTTGTTTCATAGATTTATTTA
AAAAAAGAGAAAGTCTATAGCTATAAATCTTTAAAGAGAAATATGAATACAATTCCCCTAAACTCTCCTCAAAAGAGAATTCAGTCTACA
GCCATTTAAATGATCATTGCTGCTACAGAAGTGCTTTAAGAGAATTGCCTGAAACATCTGTATTATATCGGCCACCTGCCAATCACAGCT
TTACTCTTTCAGGTCACTCTGGGGCTGCCTCTTGCATGTATTACTAAATAAAATGATCTCTCTTTCTCTCTCTCTCTCTCTTTTCTAAGA
AACAATTATGTGCACTTTGATACACAACCTTCTCTAACCAACTATATATCAAGACCCAAAAATTGAAGAAAAATATTGTTTTCTCATACA
GTGAGCAGATTTTTCAATCTACTAATTCTGTGACTTGTCTTGGTGTGCTAGCCTACACCTTCTCTTTGGTTTAGTTTTCCTTTTCTATAA
CACTCTGAATTGCTAATCTTACTAACACCTATGATGTTACCTGAAATCAATCTCCCATATGTATGCTGTATGCTATGCTAAGACTCCTGA
AATATACTTACTCTGTGCTTGTGTATGTGAATGTTAATGCAACTATTACCTAGAGTGAACTTTAAGCTTTATTGTTGAATGTAATTCCAT
TATATTTCCTTTTGTACACCTGTGAAAAAGTGGAGTAGTGTTTTTTTAACCATTGTTAATCAGCTTTTGTGTATGAAAGACACAGTAAAA
TTTCTTTCTTAAATCAAGATACTGGTGATTCAAGGAATTTTATTTATGGTCCAGCCAAGAGCCATCTCGTGCCAAGACTTCTGCTGGCAA
GGGAATGGATAAAGCTGTTTTGTTCTAGTAACAATTTTGGAATGAATACTGACAATATTCCATGAGGGTGTGCAAGCACAAATTTTACCA
ATCTGACCTCTTTGAAGTTGCAGAATGCTTTGAAATTCTAATGGTATCTGAAATATCAGCTCATAGAAAGTAACAAAATTTGCTGTCACC
TTAAATAAGACATTTTAATTTTGTTATAATGTACAATTTAGAAGTTTGATTAATTATATTATCTATTTAGGCATTAATATAAAAGAGGTA
GGAGTCTGTTATTTAAAAAAAGCATTAAATTTAAAAAAAAACTGTCTTGTCTACTTTTAGCTTCATTCTCCCATATTTTGAAGGGTGTGT
AACTTCAGCTCTGCAGGATTGCATGGGGTAAAACTTGTTACCAACACATGTGAACCATTGCTACATTGTAGGTTGTGATCATTTTGCCCC
ACTGAAGCCCATGTATCTGACCTTACGTGCCTTTTGAACTAGGAGAATCGGGCTAATTTATTAATGATGATAATTATAATGTATCTGTAC
AGCACTTTTTACATTTGCGAAGTGCTTTCCAATCCATGTTAGTTACTAGTTATTACAGCTGTAAGGATAAAACACGTCATGTGGATTCAT

>40236_40236_2_IRF1-PCDHA8_IRF1_chr5_131822248_ENST00000405885_PCDHA8_chr5_140389211_ENST00000531613_length(amino acids)=284AA_BP=181
MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPD
IEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALT
PEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQE

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Fusion Gene PPI Analysis for IRF1-PCDHA8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IRF1-PCDHA8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IRF1-PCDHA8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source