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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IRF7-IRF7 (FusionGDB2 ID:40269)

Fusion Gene Summary for IRF7-IRF7

check button Fusion gene summary
Fusion gene informationFusion gene name: IRF7-IRF7
Fusion gene ID: 40269
HgeneTgene
Gene symbol

IRF7

IRF7

Gene ID

3665

3665

Gene nameinterferon regulatory factor 7interferon regulatory factor 7
SynonymsIMD39|IRF-7|IRF-7H|IRF7A|IRF7B|IRF7C|IRF7HIMD39|IRF-7|IRF-7H|IRF7A|IRF7B|IRF7C|IRF7H
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
Descriptioninterferon regulatory factor 7interferon regulatory factor 7G isoforminterferon regulatory factor-7Hinterferon regulatory factor 7interferon regulatory factor 7G isoforminterferon regulatory factor-7H
Modification date2020031320200313
UniProtAcc.

Q92985

Ensembl transtripts involved in fusion geneENST00000330243, ENST00000348655, 
ENST00000397562, ENST00000397566, 
ENST00000397570, ENST00000397574, 
ENST00000525445, 		ENST00000330243, 
ENST00000348655, ENST00000397562, 
ENST00000397566, ENST00000397570, 
ENST00000397574, ENST00000525445, 
Fusion gene scores* DoF score3 X 4 X 2=242 X 2 X 2=8
# samples 42
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: IRF7 [Title/Abstract] AND IRF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIRF7(615585)-IRF7(614921), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIRF7

GO:0002819

regulation of adaptive immune response

17404045

HgeneIRF7

GO:0032727

positive regulation of interferon-alpha production

16127453

HgeneIRF7

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453|17404045

HgeneIRF7

GO:0051607

defense response to virus

21478870

TgeneIRF7

GO:0002819

regulation of adaptive immune response

17404045

TgeneIRF7

GO:0032727

positive regulation of interferon-alpha production

16127453

TgeneIRF7

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453|17404045

TgeneIRF7

GO:0051607

defense response to virus

21478870


check buttonFusion gene breakpoints across IRF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IRF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW134871IRF7chr11

615585

+IRF7chr11

614921

+


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Fusion Gene ORF analysis for IRF7-IRF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000330243ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000330243ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000348655ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397562ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397566ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397570ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000397574ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000330243IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000348655IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000397562IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000397566IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000397570IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000397574IRF7chr11

615585

+IRF7chr11

614921

+
intron-5UTRENST00000525445ENST00000525445IRF7chr11

615585

+IRF7chr11

614921

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IRF7-IRF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IRF7-IRF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:615585/:614921)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IRF7

Q92985

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:32972995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IRF7-IRF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IRF7-IRF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IRF7-IRF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IRF7-IRF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource