Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IRX1-ADAMTS16 (FusionGDB2 ID:40285)

Fusion Gene Summary for IRX1-ADAMTS16

Fusion gene summary

Fusion gene information	Fusion gene name: IRX1-ADAMTS16
	Fusion gene ID: 40285
		Hgene	Tgene
	Gene symbol	IRX1	ADAMTS16
	Gene ID	79192	170690
	Gene name	iroquois homeobox 1	ADAM metallopeptidase with thrombospondin type 1 motif 16
	Synonyms	IRX-5\|IRXA1	ADAMTS16s
	Cytomap	5p15.33	5p15.32
	Type of gene	protein-coding	protein-coding
	Description	iroquois-class homeodomain protein IRX-1homeodomain protein IRXA1iroquois homeobox protein 1	A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
	Modification date	20200313	20200313
	UniProtAcc	P78414	Q8TE57
	Ensembl transtripts involved in fusion gene	ENST00000302006,	ENST00000513709, ENST00000274181, ENST00000511368,
Fusion gene scores	* DoF score	1 X 1 X 1=1	4 X 6 X 3=72
	# samples	1	5
	** MAII score	log2(1/1*10)=3.32192809488736	log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IRX1 [Title/Abstract] AND ADAMTS16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IRX1(3596495)-ADAMTS16(5182157), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IRX1	GO:0000122	negative regulation of transcription by RNA polymerase II	20440264

Fusion gene breakpoints across IRX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAMTS16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-BF-AAP6-01A	IRX1	chr5	3596495	-	ADAMTS16	chr5	5182157	+
ChimerDB4	SKCM	TCGA-BF-AAP6-01A	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+

Top

Fusion Gene ORF analysis for IRX1-ADAMTS16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000302006	ENST00000513709	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+
In-frame	ENST00000302006	ENST00000274181	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+
In-frame	ENST00000302006	ENST00000511368	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000302006

IRX1

chr5

3596495

ENST00000274181

ADAMTS16

chr5

5182157

4668

328

3501

1149

ENST00000302006

IRX1

chr5

3596495

ENST00000511368

ADAMTS16

chr5

5182157

2371

328

1539

495

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000302006	ENST00000274181	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+	0.001853694	0.9981463
ENST00000302006	ENST00000511368	IRX1	chr5	3596495	+	ADAMTS16	chr5	5182157	+	0.005232377	0.99476767

Top

Fusion Genomic Features for IRX1-ADAMTS16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IRX1	chr5	3596495	+	ADAMTS16	chr5	5182156	+	3.92E-05	0.9999608
IRX1	chr5	3596495	+	ADAMTS16	chr5	5182156	+	3.92E-05	0.9999608

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IRX1-ADAMTS16

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:3596495/chr5:5182157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IRX1 P78414	ADAMTS16 Q8TE57

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

642_746

167

1225.0

Compositional bias

Note=Cys-rich

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

1051_1115

167

1225.0

Domain

TSP type-1 5

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

1127_1181

167

1225.0

Domain

TSP type-1 6

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

1186_1223

167

1225.0

Domain

PLAC

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

290_495

167

1225.0

Domain

Peptidase M12B

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

496_585

167

1225.0

Domain

Note=Disintegrin

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

586_641

167

1225.0

Domain

TSP type-1 1

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

874_922

167

1225.0

Domain

TSP type-1 2

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

927_987

167

1225.0

Domain

TSP type-1 3

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

988_1048

167

1225.0

Domain

TSP type-1 4

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

247_254

167

1225.0

Motif

Cysteine switch

Tgene

ADAMTS16

chr5:3596495

chr5:5182157

ENST00000274181

747_873

167

1225.0

Region

Note=Spacer

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IRX1

chr5:3596495

chr5:5182157

ENST00000302006

334_337

481.0

Compositional bias

Note=Poly-Pro

Hgene

IRX1

chr5:3596495

chr5:5182157

ENST00000302006

407_415

481.0

Compositional bias

Note=Poly-Pro

Hgene

IRX1

chr5:3596495

chr5:5182157

ENST00000302006

125_188

481.0

DNA binding

Homeobox%3B TALE-type

Top

Fusion Gene Sequence for IRX1-ADAMTS16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40285_40285_1_IRX1-ADAMTS16_IRX1_chr5_3596495_ENST00000302006_ADAMTS16_chr5_5182157_ENST00000274181_length(transcript)=4668nt_BP=328nt
CTCCCCGCGCCTTTAATACTCGCCCGCTGCGGCGGTCGCCGAGTCCGCGGACATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAG
CGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCGGCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACC
GGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTGCTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGC
GCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCGCAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTA
CTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATC
CACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCT
TCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCC
AGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGT
CGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGA
TGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGC
AGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGG
TCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCAC
GATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAA
CATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTA
TCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCC
AGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTG
TAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATGCCAGCAGCAGAAGGCACAATTTGTGGGCATGACATGTG
GTGCCGGGGAGGACAGTGTGTGAAATATGGTGATGAAGGCCCCAAGCCCACCCATGGCCACTGGTCGGACTGGTCTTCTTGGTCCCCATG
CTCCAGGACCTGCGGAGGGGGAGTATCTCATAGGAGTCGCCTCTGCACCAACCCCAAGCCATCGCATGGAGGGAAGTTCTGTGAGGGCTC
CACTCGCACTCTGAAGCTCTGCAACAGTCAGAAATGTCCCCGGGACAGTGTTGACTTCCGTGCTGCTCAGTGTGCCGAGCACAACAGCAG
ACGATTCAGAGGGCGGCACTACAAGTGGAAGCCTTACACTCAAGTAGAAGATCAGGACTTATGCAAACTCTACTGTATCGCAGAAGGATT
TGATTTCTTCTTTTCTTTGTCAAATAAAGTCAAAGATGGGACTCCATGCTCGGAGGATAGCCGTAATGTTTGTATAGATGGGATATGTGA
GAGAGTTGGATGTGACAATGTCCTTGGATCTGATGCTGTTGAAGACGTCTGTGGGGTGTGTAACGGGAATAACTCAGCCTGCACGATTCA
CAGGGGTCTCTACACCAAGCACCACCACACCAACCAGTATTATCACATGGTCACCATTCCTTCTGGAGCCCGGAGTATCCGCATCTATGA
AATGAACGTCTCTACCTCCTACATTTCTGTGCGCAATGCCCTCAGAAGGTACTACCTGAATGGGCACTGGACCGTGGACTGGCCCGGCCG
GTACAAATTTTCGGGCACTACTTTCGACTACAGACGGTCCTATAATGAGCCCGAGAACTTAATCGCTACTGGACCAACCAACGAGACACT
GATTGTGGAGCTGCTGTTTCAGGGAAGGAACCCGGGTGTTGCCTGGGAATACTCCATGCCTCGCTTGGGGACCGAGAAGCAGCCCCCTGC
CCAGCCCAGCTACACTTGGGCCATCGTGCGCTCTGAGTGCTCCGTGTCCTGCGGAGGGGGACAGATGACCGTGAGAGAGGGCTGCTACAG
AGACCTGAAGTTTCAAGTAAATATGTCCTTCTGCAATCCCAAGACACGACCTGTCACGGGGCTGGTGCCTTGCAAAGTATCTGCCTGTCC
TCCCAGCTGGTCCGTGGGGAACTGGAGTGCCTGCAGTCGGACGTGTGGCGGGGGTGCCCAGAGCCGCCCCGTGCAGTGCACACGGCGGGT
GCACTATGACTCGGAGCCAGTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCCTCCAGCAGGCAGGCCTGCAACTCTCAGAGCTGCCCACC
TGCATGGAGCGCCGGGCCCTGGGCAGAGTGCTCACACACCTGTGGGAAGGGGTGGAGGAAGCGGGCAGTGGCCTGTAAGAGCACCAACCC
CTCGGCCAGAGCGCAGCTGCTGCCCGACGCTGTCTGCACCTCCGAGCCCAAGCCCAGGATGCATGAAGCCTGTCTGCTTCAGCGCTGCCA
CAAGCCCAAGAAGCTGCAGTGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTGACATGTGAAAGAGGAACACAGAAAAGATTCTTAAAATG
TGCTGAAAAGTATGTTTCTGGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGCTCACATTTGCCGAAGCCCAGCCTGGAGCTGGAACGTGC
CTGCGCCCCGCTTCCATGCCCCAGGCACCCCCCATTTGCTGCTGCGGGACCCTCGAGGGGCAGCTGGTTTGCCTCACCCTGGTCTCAGTG
CACGGCCAGCTGTGGGGGAGGCGTTCAGACGAGGTCCGTGCAGTGCCTGGCTGGGGGCCGGCCGGCCTCAGGCTGCCTCCTGCACCAGAA
GCCTTCGGCCTCCCTGGCCTGCAACACTCACTTCTGCCCCATTGCAGAGAAGAAAGATGCCTTCTGCAAAGACTACTTCCACTGGTGCTA
CCTGGTACCCCAGCACGGGATGTGCAGCCACAAGTTCTACGGCAAGCAGTGCTGCAAGACTTGCTCTAAGTCCAACTTGTGAGTTGGGAC
CGCTCTCCGTAGCAGAGAAAGTGCCTGCGTGGCACAGAAATTTCCCACAAATGAGCTGTGCAATCTACGTCGGAATACATCCAAGGAAGA
GCAAAGCCAAAAGAAGAAAACCGTGTTAGGCTCTTTGACCAGGAGTGTATGTATGTGTTTCACTGTGAGCCTGGGTGCAGACCTGTGTCC
CCATGCACACAGTGTCTCCTGTCAGGCTGAAATGTGGCACCCTGGCAGACAGAGCTGTGGCTCGTGAGGCAGAAGGCAGGCACCACAACG
GGAGAGGCAGCACTCACCCCTGCCTGTTGCAGCTAAATCAAGTCAAAAAGACAGGCGAGGCTGAACTTGCTAAATGTCTGGTGCCTTAGA
AAAAGAAGGAAAGGCCATGAAATAAGGAAAACATACAAAATATGTACCCCCTAGTTCACCAGCCTCCCCTCCCACTAGGAGGGCCCCTCG
AGCCATCAGGAGTGACCAACTTCCTGGGTGGAGGTCAGGGGAGCTCCAGGAGGCTGCCCAGGCTCCTCCTCCTCCTCCCCAGCGGCCGAG
CATCTCTTACCAGGAACCTGGAGCCACCGCCGGAGCCAGCGTCATCTCTAGGGTCACTGGCCAGGGGACTGCATTCTGGTTTGGGACTTT
GCCTATGGAAATGGGAAAAATGAAATTCCTGCTAAGGTGCTTCTATCTCTTTCAGATTCATGCATTGAAGGAGAGATTTTTTATACTTTA
TGTTTTATCTTTCTCAGTTATTTGCAAGTGAGTGTCCTTTTAAAAACACACTTCTTCATGCTTTTCTTTGTAAATGACAGATCGAAGTAT
AGGTTACATCAAAACCCTACCATCCTGAGAAGAGTTATGGTTCTATTATAGCAGACGTCAGCCACACAGCCTATGTGACAATAACCTTAG
AGTCCTGTGTTTTGTTTTTGTGTGTTGTGAGATTTTAATCTTTTTTTTTTCGGTGAGTCTGGCCATTTCTATAATGCCAGGTGGGAAGCC
AGGCTGCGGGTGTTAGGGTGGGAATCTGCCCGGCGTCTCTGGCACCCTCCCTGCCATCCTCAGTGCGGCTGCTGTTCTCCTGTCCGGTGC

>40285_40285_1_IRX1-ADAMTS16_IRX1_chr5_3596495_ENST00000302006_ADAMTS16_chr5_5182157_ENST00000274181_length(amino acids)=1149AA_BP=92
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFS
QMSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKY
MPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILL
EDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHES
GHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEK
AKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTN
PKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCS
EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRY
YLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSC
GGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAP
SSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSV
TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLA

--------------------------------------------------------------
>40285_40285_2_IRX1-ADAMTS16_IRX1_chr5_3596495_ENST00000302006_ADAMTS16_chr5_5182157_ENST00000511368_length(transcript)=2371nt_BP=328nt
CTCCCCGCGCCTTTAATACTCGCCCGCTGCGGCGGTCGCCGAGTCCGCGGACATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAG
CGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCGGCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACC
GGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTGCTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGC
GCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCGCAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTA
CTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATC
CACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCT
TCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCC
AGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGT
CGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGA
TGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGC
AGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGG
TCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCAC
GATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAA
CATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTA
TCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCC
AGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTG
TAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATGCCAGCAGCAGAAGGCACAATTTGTGGGCATGACATGGT
AAGAAGCTAACTGTAGGTACAGCATCGTATTCAGATGCTAGTCTTTCAACCCATGCATCTTTGCTCCTCTTGCATAGGTATTTTTAAAAC
ATGTATTTCTCATATACATATGCATACCCATGCTCCTATCAAACACTGTGTTTATTTTATATTGATAATGTGAAGAGGAATCCTTTTCTC
ACTTTTGTGAAAATAAAATTGATGAGCTACCTGGAATTCATAGACATAGAAATCAGACAACAGGTGATGACAGATTCAGTCTATTGAGGG
GAAACATTAAGCCATTGACCACCATTTATCATGGAAAGGACCAGCATTAAACAGTGCTGTGAAAGCCACAGAACATCGGTTTGAAGACCC
TGGAGCACATCATTTTCACCTATTGTTGCCTCTGTGAGAAGAGAGAGAGCTATGGTAGAGAAAAGAAGAAGTATACAAGATGTTGCAGCA
ATGTGGACGTAGTTGGAGGCCATTCATTATCCTAGGCAAACTAATGCAGGAACAGAAAACCAAATACTGCATGTTGTTACTTATAAGCAG
GAGCTAAACACTGAGTACACATGGACACAAAGATGGGAACCATAGACCCCGGGGACTACTTAAGGGGGGATGGTGGGAGGGGGCAAGGGT
TGAAACACTATCCCATATTGTGCTTGCTGCATGGGTGATGAGGTTATTCGAATGCCAAACTTTAGTGACACGTAATCTACCCATGTAACA
AATCTGCACATGTACCCCTGAACCTAAAACAAAAGTCGGAAAAAAAAGAAATATACAAGATAACAAGTTTATTACTAAATGGTAAAGAAT

>40285_40285_2_IRX1-ADAMTS16_IRX1_chr5_3596495_ENST00000302006_ADAMTS16_chr5_5182157_ENST00000511368_length(amino acids)=495AA_BP=92
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFS
QMSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKY
MPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILL
EDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHES
GHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IRX1-ADAMTS16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IRX1-ADAMTS16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IRX1-ADAMTS16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source