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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ISCA1-LINGO2 (FusionGDB2 ID:40295)

Fusion Gene Summary for ISCA1-LINGO2

Fusion gene summary

Fusion gene information	Fusion gene name: ISCA1-LINGO2
	Fusion gene ID: 40295
		Hgene	Tgene
	Gene symbol	ISCA1	LINGO2
	Gene ID	81689	158038
	Gene name	iron-sulfur cluster assembly 1	leucine rich repeat and Ig domain containing 2
	Synonyms	HBLD2\|ISA1\|MMDS5\|hIscA	LERN3\|LRRN6C
	Cytomap	9q21.33	9p21.2-p21.1
	Type of gene	protein-coding	protein-coding
	Description	iron-sulfur cluster assembly 1 homolog, mitochondrialHESB like domain containing 2HESB-like domain-containing protein 2iron-sulfur assembly protein IscA	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2leucine rich repeat neuronal 6Cleucine-rich repeat neuronal protein 3leucine-rich repeat neuronal protein 6C
	Modification date	20200313	20200313
	UniProtAcc	Q9BUE6	Q7L985
	Ensembl transtripts involved in fusion gene	ENST00000326094, ENST00000375991, ENST00000452279, ENST00000311534,	ENST00000308675, ENST00000493941, ENST00000379992,
Fusion gene scores	* DoF score	5 X 4 X 4=80	11 X 8 X 8=704
	# samples	5	13
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/704*10)=-2.43706380560884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ISCA1 [Title/Abstract] AND LINGO2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ISCA1(88897293)-LINGO2(28670278), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ISCA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LINGO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-P7-A5NX-01A	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-

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Fusion Gene ORF analysis for ISCA1-LINGO2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000326094	ENST00000308675	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
5CDS-intron	ENST00000326094	ENST00000493941	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
5CDS-intron	ENST00000375991	ENST00000308675	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
5CDS-intron	ENST00000375991	ENST00000493941	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
5CDS-intron	ENST00000452279	ENST00000308675	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
5CDS-intron	ENST00000452279	ENST00000493941	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
In-frame	ENST00000326094	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
In-frame	ENST00000375991	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
In-frame	ENST00000452279	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
intron-3CDS	ENST00000311534	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
intron-intron	ENST00000311534	ENST00000308675	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-
intron-intron	ENST00000311534	ENST00000493941	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375991	ISCA1	chr9	88897293	-	ENST00000379992	LINGO2	chr9	28670278	-	3196	152	602	2422	606
ENST00000452279	ISCA1	chr9	88897293	-	ENST00000379992	LINGO2	chr9	28670278	-	3428	384	834	2654	606
ENST00000326094	ISCA1	chr9	88897293	-	ENST00000379992	LINGO2	chr9	28670278	-	3205	161	611	2431	606

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375991	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-	0.001477967	0.9985221
ENST00000452279	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-	0.001935249	0.9980647
ENST00000326094	ENST00000379992	ISCA1	chr9	88897293	-	LINGO2	chr9	28670278	-	0.001495712	0.9985043

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Fusion Genomic Features for ISCA1-LINGO2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ISCA1-LINGO2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:88897293/chr9:28670278)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ISCA1 Q9BUE6	LINGO2 Q7L985
FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269\|PubMed:15262227, ECO:0000269\|PubMed:22323289}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

28_57

607.0

Domain

Note=LRRNT

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

355_409

607.0

Domain

Note=LRRCT

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

410_499

607.0

Domain

Note=Ig-like C2-type

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

28_57

607.0

Domain

Note=LRRNT

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

355_409

607.0

Domain

Note=LRRCT

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

410_499

607.0

Domain

Note=Ig-like C2-type

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

106_127

607.0

Repeat

Note=LRR 3

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

130_151

607.0

Repeat

Note=LRR 4

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

154_175

607.0

Repeat

Note=LRR 5

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

178_199

607.0

Repeat

Note=LRR 6

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

202_223

607.0

Repeat

Note=LRR 7

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

226_247

607.0

Repeat

Note=LRR 8

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

250_271

607.0

Repeat

Note=LRR 9

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

274_295

607.0

Repeat

Note=LRR 10

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

298_319

607.0

Repeat

Note=LRR 11

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

322_343

607.0

Repeat

Note=LRR 12

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

58_79

607.0

Repeat

Note=LRR 1

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

82_103

607.0

Repeat

Note=LRR 2

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

106_127

607.0

Repeat

Note=LRR 3

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

130_151

607.0

Repeat

Note=LRR 4

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

154_175

607.0

Repeat

Note=LRR 5

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

178_199

607.0

Repeat

Note=LRR 6

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

202_223

607.0

Repeat

Note=LRR 7

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

226_247

607.0

Repeat

Note=LRR 8

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

250_271

607.0

Repeat

Note=LRR 9

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

274_295

607.0

Repeat

Note=LRR 10

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

298_319

607.0

Repeat

Note=LRR 11

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

322_343

607.0

Repeat

Note=LRR 12

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

58_79

607.0

Repeat

Note=LRR 1

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

82_103

607.0

Repeat

Note=LRR 2

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

28_545

607.0

Topological domain

Extracellular

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

567_606

607.0

Topological domain

Cytoplasmic

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

28_545

607.0

Topological domain

Extracellular

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

567_606

607.0

Topological domain

Cytoplasmic

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000308675

546_566

607.0

Transmembrane

Helical

Tgene

LINGO2

chr9:88897293

chr9:28670278

ENST00000379992

-1

546_566

607.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ISCA1-LINGO2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40295_40295_1_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000326094_LINGO2_chr9_28670278_ENST00000379992_length(transcript)=3205nt_BP=161nt
AATGCGCCCGCCGTGTCCATGGAGAGAAGCTGAGGCGGCCGACCTTCGGCCCGAGGCACCGGGGCGCCGGGACGGCGAAGATGTCGGCTT
CCTTAGTCCGGGCAACTGTCCGGGCTGTGAGCAAGAGGAAGCTGCAGCCCACCCGGGCAGCCCTCACCCTGTGTAGGAATTGATGAGTGC
CATCAGAAAGCTGTATCATGAGCTGCCTGCACTTCTAAAGTGTCCAGTGGATTTTTAATCACATGAGCCTGGAAATAGGGTTATGAGAAG
AAGCTCAGAGCAGAGCACCGAAAGTGGCCACTACCAGCATGAAGAGCCCAACAATTCAAACTGGTGAAGTGAGAAAAACAGAATGCAGCT
TTCAAGGTTCGTTTCAAGCAGTTGGCTTGTGGGACTCTGAGAGATGCTGCTGCCCATGACATGCGGGAATTATCATGATCAACTACCCAG
CTTGGATTTCACCCAGTGGCCAAGAGCTTTGTGTGGGAGACGGCAAGGGTTGGATTTTTCAAAAGAGTAAACCAGGATAAATCATGAGGA
ACCTATAACCCTTTTGGCCACATGCAAAAAAGCAAGACCCGTGACCAAGGTGTAGACTAAGAAGTGGAGTCATGCTTCACACGGCCATAT
CATGCTGGCAGCCATTCCTGGGTCTGGCTGTGGTGTTAATCTTCATGGGATCCACCATTGGCTGCCCCGCTCGCTGTGAGTGCTCTGCCC
AGAACAAATCTGTTAGCTGTCACAGAAGGCGATTGATCGCCATCCCAGAGGGCATTCCCATCGAAACCAAAATCTTGGACCTCAGTAAAA
ACAGGCTAAAAAGCGTCAACCCTGAAGAATTCATATCATATCCTCTGCTGGAAGAGATAGACTTGAGTGACAACATCATTGCCAATGTGG
AACCAGGAGCATTCAACAATCTCTTTAACCTGCGTTCCCTCCGCCTAAAAGGCAATCGTCTAAAGCTGGTCCCTTTGGGAGTATTCACGG
GGCTGTCCAATCTCACTAAGCTTGACATTAGTGAGAATAAGATTGTCATTTTACTAGACTACATGTTCCAAGATCTACATAACCTGAAGT
CTCTAGAAGTGGGGGACAATGATTTGGTTTATATATCACACAGGGCATTCAGTGGGCTTCTTAGCTTGGAGCAGCTCACCCTGGAGAAAT
GCAACTTAACAGCAGTACCAACAGAAGCCCTCTCCCACCTCCGCAGCCTCATCAGCCTGCATCTGAAGCATCTCAATATCAACAATATGC
CTGTGTATGCCTTTAAAAGATTGTTCCACCTGAAACACCTAGAGATTGACTATTGGCCTTTACTGGATATGATGCCTGCCAATAGCCTCT
ACGGTCTCAACCTCACATCCCTTTCAGTCACCAACACCAATCTGTCTACTGTACCCTTCCTTGCCTTTAAACACCTGGTATACCTGACTC
ACCTTAACCTCTCCTACAATCCCATCAGCACTATTGAAGCAGGCATGTTCTCTGACCTGATCCGCCTTCAGGAGCTTCATATAGTGGGGG
CCCAGCTTCGCACCATTGAGCCTCACTCCTTCCAAGGGCTCCGCTTCCTACGCGTGCTCAATGTGTCTCAGAACCTGCTGGAAACTTTGG
AAGAGAATGTCTTCTCCTCCCCTAGGGCTCTGGAGGTCTTGAGCATTAACAACAACCCTCTGGCCTGTGACTGCCGCCTTCTCTGGATCT
TGCAGCGACAGCCCACCCTGCAGTTTGGTGGCCAGCAACCTATGTGTGCTGGCCCAGACACCATCCGTGAGAGGTCTTTCAAGGATTTCC
ATAGCACTGCCCTTTCTTTTTACTTTACCTGCAAAAAACCCAAAATCCGTGAAAAGAAGTTGCAGCATCTGCTAGTAGATGAAGGGCAGA
CAGTCCAGCTAGAATGCAGTGCAGATGGAGACCCGCAGCCTGTGATTTCCTGGGTGACACCCCGAAGGCGTTTCATCACCACCAAGTCCA
ATGGAAGAGCCACCGTGTTGGGTGATGGCACCTTGGAAATCCGCTTTGCCCAGGATCAAGACAGCGGGATGTATGTTTGCATCGCTAGCA
ATGCTGCTGGGAATGATACCTTCACAGCCTCCTTAACTGTGAAAGGATTCGCTTCAGATCGTTTTCTTTATGCGAACAGGACCCCTATGT
ACATGACCGACTCCAATGACACCATTTCCAATGGCACCAATGCCAATACTTTTTCCCTGGACCTTAAAACAATACTGGTGTCTACAGCTA
TGGGCTGCTTCACATTCCTGGGAGTGGTTTTATTTTGTTTTCTTCTCCTTTTTGTGTGGAGCCGAGGGAAAGGCAAGCACAAAAACAGCA
TTGACCTTGAGTATGTGCCCAGAAAAAACAATGGTGCTGTTGTGGAAGGGGAGGTAGCTGGACCCAGGAGGTTCAACATGAAAATGATTT
GAAGGCCCACCCCTCACATTACTGTCTCTTTGTCAATGTGGGTAATCAGTAAGACAGTATGGCACAGTAAATTACTAGATTAAGAGGCAG
CCATGTGCAGCTGCCCCTGTATCAAAAGCAGGGTCTATGGAAGCAGGAGGACTTCCAATGGAGACTCTCCATCGAAAGGCAGGCAGGCAG
GCATGTGTCAGAGCCCTTCACACAGTGGGATACTAAGTGTTTGCGTTGCAAATATTGGCGTTCTGGGGATCTCAGTAATGAACCTGAATA
TTTGGCTCACACTCACGGACAATTATTCAGCATTTTCTACCACTGCAAAAAACAAAAGAAAAAATAAAAAAGAACAACCTACAGTGTAGG
ATTTACATATTAAAAAGACACATTTGTCTAAAACATACTCTACAGAAAAATTTGTATCTATGATTATCATTTGTTAAAGCCTTGCATCAT
ACCATATTGTTGGTTCAGTACCACAAAGAGATCAATATATTCTTTTCTTCCTTTTTTGAAACATATATGCTGTACATGTTTTAAAGCAAT
ATGAATGAGAGGTTGTGCTTTTAGTTACTCACCACTATAGATCCAAGTGTGATTTCACCTTCCGTTACCTACAGATGACCCTGAGACTAG
ATCCCTGGAGTTATGGGCGGAGATATTTTGAGAGATGTGTTTGTCTGATGTAGGATGCCAAGAAACAGGACCCAAGGCAAAACTGCTCAA

>40295_40295_1_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000326094_LINGO2_chr9_28670278_ENST00000379992_length(amino acids)=606AA_BP=
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSD
NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK
HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT

--------------------------------------------------------------
>40295_40295_2_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000375991_LINGO2_chr9_28670278_ENST00000379992_length(transcript)=3196nt_BP=152nt
GCCGTGTCCATGGAGAGAAGCTGAGGCGGCCGACCTTCGGCCCGAGGCACCGGGGCGCCGGGACGGCGAAGATGTCGGCTTCCTTAGTCC
GGGCAACTGTCCGGGCTGTGAGCAAGAGGAAGCTGCAGCCCACCCGGGCAGCCCTCACCCTGTGTAGGAATTGATGAGTGCCATCAGAAA
GCTGTATCATGAGCTGCCTGCACTTCTAAAGTGTCCAGTGGATTTTTAATCACATGAGCCTGGAAATAGGGTTATGAGAAGAAGCTCAGA
GCAGAGCACCGAAAGTGGCCACTACCAGCATGAAGAGCCCAACAATTCAAACTGGTGAAGTGAGAAAAACAGAATGCAGCTTTCAAGGTT
CGTTTCAAGCAGTTGGCTTGTGGGACTCTGAGAGATGCTGCTGCCCATGACATGCGGGAATTATCATGATCAACTACCCAGCTTGGATTT
CACCCAGTGGCCAAGAGCTTTGTGTGGGAGACGGCAAGGGTTGGATTTTTCAAAAGAGTAAACCAGGATAAATCATGAGGAACCTATAAC
CCTTTTGGCCACATGCAAAAAAGCAAGACCCGTGACCAAGGTGTAGACTAAGAAGTGGAGTCATGCTTCACACGGCCATATCATGCTGGC
AGCCATTCCTGGGTCTGGCTGTGGTGTTAATCTTCATGGGATCCACCATTGGCTGCCCCGCTCGCTGTGAGTGCTCTGCCCAGAACAAAT
CTGTTAGCTGTCACAGAAGGCGATTGATCGCCATCCCAGAGGGCATTCCCATCGAAACCAAAATCTTGGACCTCAGTAAAAACAGGCTAA
AAAGCGTCAACCCTGAAGAATTCATATCATATCCTCTGCTGGAAGAGATAGACTTGAGTGACAACATCATTGCCAATGTGGAACCAGGAG
CATTCAACAATCTCTTTAACCTGCGTTCCCTCCGCCTAAAAGGCAATCGTCTAAAGCTGGTCCCTTTGGGAGTATTCACGGGGCTGTCCA
ATCTCACTAAGCTTGACATTAGTGAGAATAAGATTGTCATTTTACTAGACTACATGTTCCAAGATCTACATAACCTGAAGTCTCTAGAAG
TGGGGGACAATGATTTGGTTTATATATCACACAGGGCATTCAGTGGGCTTCTTAGCTTGGAGCAGCTCACCCTGGAGAAATGCAACTTAA
CAGCAGTACCAACAGAAGCCCTCTCCCACCTCCGCAGCCTCATCAGCCTGCATCTGAAGCATCTCAATATCAACAATATGCCTGTGTATG
CCTTTAAAAGATTGTTCCACCTGAAACACCTAGAGATTGACTATTGGCCTTTACTGGATATGATGCCTGCCAATAGCCTCTACGGTCTCA
ACCTCACATCCCTTTCAGTCACCAACACCAATCTGTCTACTGTACCCTTCCTTGCCTTTAAACACCTGGTATACCTGACTCACCTTAACC
TCTCCTACAATCCCATCAGCACTATTGAAGCAGGCATGTTCTCTGACCTGATCCGCCTTCAGGAGCTTCATATAGTGGGGGCCCAGCTTC
GCACCATTGAGCCTCACTCCTTCCAAGGGCTCCGCTTCCTACGCGTGCTCAATGTGTCTCAGAACCTGCTGGAAACTTTGGAAGAGAATG
TCTTCTCCTCCCCTAGGGCTCTGGAGGTCTTGAGCATTAACAACAACCCTCTGGCCTGTGACTGCCGCCTTCTCTGGATCTTGCAGCGAC
AGCCCACCCTGCAGTTTGGTGGCCAGCAACCTATGTGTGCTGGCCCAGACACCATCCGTGAGAGGTCTTTCAAGGATTTCCATAGCACTG
CCCTTTCTTTTTACTTTACCTGCAAAAAACCCAAAATCCGTGAAAAGAAGTTGCAGCATCTGCTAGTAGATGAAGGGCAGACAGTCCAGC
TAGAATGCAGTGCAGATGGAGACCCGCAGCCTGTGATTTCCTGGGTGACACCCCGAAGGCGTTTCATCACCACCAAGTCCAATGGAAGAG
CCACCGTGTTGGGTGATGGCACCTTGGAAATCCGCTTTGCCCAGGATCAAGACAGCGGGATGTATGTTTGCATCGCTAGCAATGCTGCTG
GGAATGATACCTTCACAGCCTCCTTAACTGTGAAAGGATTCGCTTCAGATCGTTTTCTTTATGCGAACAGGACCCCTATGTACATGACCG
ACTCCAATGACACCATTTCCAATGGCACCAATGCCAATACTTTTTCCCTGGACCTTAAAACAATACTGGTGTCTACAGCTATGGGCTGCT
TCACATTCCTGGGAGTGGTTTTATTTTGTTTTCTTCTCCTTTTTGTGTGGAGCCGAGGGAAAGGCAAGCACAAAAACAGCATTGACCTTG
AGTATGTGCCCAGAAAAAACAATGGTGCTGTTGTGGAAGGGGAGGTAGCTGGACCCAGGAGGTTCAACATGAAAATGATTTGAAGGCCCA
CCCCTCACATTACTGTCTCTTTGTCAATGTGGGTAATCAGTAAGACAGTATGGCACAGTAAATTACTAGATTAAGAGGCAGCCATGTGCA
GCTGCCCCTGTATCAAAAGCAGGGTCTATGGAAGCAGGAGGACTTCCAATGGAGACTCTCCATCGAAAGGCAGGCAGGCAGGCATGTGTC
AGAGCCCTTCACACAGTGGGATACTAAGTGTTTGCGTTGCAAATATTGGCGTTCTGGGGATCTCAGTAATGAACCTGAATATTTGGCTCA
CACTCACGGACAATTATTCAGCATTTTCTACCACTGCAAAAAACAAAAGAAAAAATAAAAAAGAACAACCTACAGTGTAGGATTTACATA
TTAAAAAGACACATTTGTCTAAAACATACTCTACAGAAAAATTTGTATCTATGATTATCATTTGTTAAAGCCTTGCATCATACCATATTG
TTGGTTCAGTACCACAAAGAGATCAATATATTCTTTTCTTCCTTTTTTGAAACATATATGCTGTACATGTTTTAAAGCAATATGAATGAG
AGGTTGTGCTTTTAGTTACTCACCACTATAGATCCAAGTGTGATTTCACCTTCCGTTACCTACAGATGACCCTGAGACTAGATCCCTGGA
GTTATGGGCGGAGATATTTTGAGAGATGTGTTTGTCTGATGTAGGATGCCAAGAAACAGGACCCAAGGCAAAACTGCTCAACTCTGTTAA

>40295_40295_2_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000375991_LINGO2_chr9_28670278_ENST00000379992_length(amino acids)=606AA_BP=
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSD
NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK
HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT

--------------------------------------------------------------
>40295_40295_3_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000452279_LINGO2_chr9_28670278_ENST00000379992_length(transcript)=3428nt_BP=384nt
GGCGGTGAAGACATTCCTCCCGGGCCCTGCGCCCTGCAGCGTGGTAACCCCACTGCCGGAGACCGTGCGCAACCCAGCTGCTAGACCCCC
GGCGTTGAGCGGCAAAACCCCGCCCCGAGCGGCTTGCCCCGCCCCCGGCTCGTCACTCATGCAACTCACCCAATGGTGGCGGCGGGGGGC
GGGGCTAGGACTGAGGGCGCCGTGCGCCGAAGCTTGTGGCGTCAATGCGCCCGCCGTGTCCATGGAGAGAAGCTGAGGCGGCCGACCTTC
GGCCCGAGGCACCGGGGCGCCGGGACGGCGAAGATGTCGGCTTCCTTAGTCCGGGCAACTGTCCGGGCTGTGAGCAAGAGGAAGCTGCAG
CCCACCCGGGCAGCCCTCACCCTGTGTAGGAATTGATGAGTGCCATCAGAAAGCTGTATCATGAGCTGCCTGCACTTCTAAAGTGTCCAG
TGGATTTTTAATCACATGAGCCTGGAAATAGGGTTATGAGAAGAAGCTCAGAGCAGAGCACCGAAAGTGGCCACTACCAGCATGAAGAGC
CCAACAATTCAAACTGGTGAAGTGAGAAAAACAGAATGCAGCTTTCAAGGTTCGTTTCAAGCAGTTGGCTTGTGGGACTCTGAGAGATGC
TGCTGCCCATGACATGCGGGAATTATCATGATCAACTACCCAGCTTGGATTTCACCCAGTGGCCAAGAGCTTTGTGTGGGAGACGGCAAG
GGTTGGATTTTTCAAAAGAGTAAACCAGGATAAATCATGAGGAACCTATAACCCTTTTGGCCACATGCAAAAAAGCAAGACCCGTGACCA
AGGTGTAGACTAAGAAGTGGAGTCATGCTTCACACGGCCATATCATGCTGGCAGCCATTCCTGGGTCTGGCTGTGGTGTTAATCTTCATG
GGATCCACCATTGGCTGCCCCGCTCGCTGTGAGTGCTCTGCCCAGAACAAATCTGTTAGCTGTCACAGAAGGCGATTGATCGCCATCCCA
GAGGGCATTCCCATCGAAACCAAAATCTTGGACCTCAGTAAAAACAGGCTAAAAAGCGTCAACCCTGAAGAATTCATATCATATCCTCTG
CTGGAAGAGATAGACTTGAGTGACAACATCATTGCCAATGTGGAACCAGGAGCATTCAACAATCTCTTTAACCTGCGTTCCCTCCGCCTA
AAAGGCAATCGTCTAAAGCTGGTCCCTTTGGGAGTATTCACGGGGCTGTCCAATCTCACTAAGCTTGACATTAGTGAGAATAAGATTGTC
ATTTTACTAGACTACATGTTCCAAGATCTACATAACCTGAAGTCTCTAGAAGTGGGGGACAATGATTTGGTTTATATATCACACAGGGCA
TTCAGTGGGCTTCTTAGCTTGGAGCAGCTCACCCTGGAGAAATGCAACTTAACAGCAGTACCAACAGAAGCCCTCTCCCACCTCCGCAGC
CTCATCAGCCTGCATCTGAAGCATCTCAATATCAACAATATGCCTGTGTATGCCTTTAAAAGATTGTTCCACCTGAAACACCTAGAGATT
GACTATTGGCCTTTACTGGATATGATGCCTGCCAATAGCCTCTACGGTCTCAACCTCACATCCCTTTCAGTCACCAACACCAATCTGTCT
ACTGTACCCTTCCTTGCCTTTAAACACCTGGTATACCTGACTCACCTTAACCTCTCCTACAATCCCATCAGCACTATTGAAGCAGGCATG
TTCTCTGACCTGATCCGCCTTCAGGAGCTTCATATAGTGGGGGCCCAGCTTCGCACCATTGAGCCTCACTCCTTCCAAGGGCTCCGCTTC
CTACGCGTGCTCAATGTGTCTCAGAACCTGCTGGAAACTTTGGAAGAGAATGTCTTCTCCTCCCCTAGGGCTCTGGAGGTCTTGAGCATT
AACAACAACCCTCTGGCCTGTGACTGCCGCCTTCTCTGGATCTTGCAGCGACAGCCCACCCTGCAGTTTGGTGGCCAGCAACCTATGTGT
GCTGGCCCAGACACCATCCGTGAGAGGTCTTTCAAGGATTTCCATAGCACTGCCCTTTCTTTTTACTTTACCTGCAAAAAACCCAAAATC
CGTGAAAAGAAGTTGCAGCATCTGCTAGTAGATGAAGGGCAGACAGTCCAGCTAGAATGCAGTGCAGATGGAGACCCGCAGCCTGTGATT
TCCTGGGTGACACCCCGAAGGCGTTTCATCACCACCAAGTCCAATGGAAGAGCCACCGTGTTGGGTGATGGCACCTTGGAAATCCGCTTT
GCCCAGGATCAAGACAGCGGGATGTATGTTTGCATCGCTAGCAATGCTGCTGGGAATGATACCTTCACAGCCTCCTTAACTGTGAAAGGA
TTCGCTTCAGATCGTTTTCTTTATGCGAACAGGACCCCTATGTACATGACCGACTCCAATGACACCATTTCCAATGGCACCAATGCCAAT
ACTTTTTCCCTGGACCTTAAAACAATACTGGTGTCTACAGCTATGGGCTGCTTCACATTCCTGGGAGTGGTTTTATTTTGTTTTCTTCTC
CTTTTTGTGTGGAGCCGAGGGAAAGGCAAGCACAAAAACAGCATTGACCTTGAGTATGTGCCCAGAAAAAACAATGGTGCTGTTGTGGAA
GGGGAGGTAGCTGGACCCAGGAGGTTCAACATGAAAATGATTTGAAGGCCCACCCCTCACATTACTGTCTCTTTGTCAATGTGGGTAATC
AGTAAGACAGTATGGCACAGTAAATTACTAGATTAAGAGGCAGCCATGTGCAGCTGCCCCTGTATCAAAAGCAGGGTCTATGGAAGCAGG
AGGACTTCCAATGGAGACTCTCCATCGAAAGGCAGGCAGGCAGGCATGTGTCAGAGCCCTTCACACAGTGGGATACTAAGTGTTTGCGTT
GCAAATATTGGCGTTCTGGGGATCTCAGTAATGAACCTGAATATTTGGCTCACACTCACGGACAATTATTCAGCATTTTCTACCACTGCA
AAAAACAAAAGAAAAAATAAAAAAGAACAACCTACAGTGTAGGATTTACATATTAAAAAGACACATTTGTCTAAAACATACTCTACAGAA
AAATTTGTATCTATGATTATCATTTGTTAAAGCCTTGCATCATACCATATTGTTGGTTCAGTACCACAAAGAGATCAATATATTCTTTTC
TTCCTTTTTTGAAACATATATGCTGTACATGTTTTAAAGCAATATGAATGAGAGGTTGTGCTTTTAGTTACTCACCACTATAGATCCAAG
TGTGATTTCACCTTCCGTTACCTACAGATGACCCTGAGACTAGATCCCTGGAGTTATGGGCGGAGATATTTTGAGAGATGTGTTTGTCTG
ATGTAGGATGCCAAGAAACAGGACCCAAGGCAAAACTGCTCAACTCTGTTAACTTCTGTTACTATAAATAAAGGCATGTGCCTAGTTTTG

>40295_40295_3_ISCA1-LINGO2_ISCA1_chr9_88897293_ENST00000452279_LINGO2_chr9_28670278_ENST00000379992_length(amino acids)=606AA_BP=
MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSD
NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE
QLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK
HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACD
CRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ISCA1-LINGO2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ISCA1-LINGO2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ISCA1-LINGO2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source