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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ALG6-SLC22A15 (FusionGDB2 ID:4032)

Fusion Gene Summary for ALG6-SLC22A15

Fusion gene summary

Fusion gene information	Fusion gene name: ALG6-SLC22A15
	Fusion gene ID: 4032
		Hgene	Tgene
	Gene symbol	ALG6	SLC22A15
	Gene ID	29929	55356
	Gene name	ALG6 alpha-1,3-glucosyltransferase	solute carrier family 22 member 15
	Synonyms	CDG1C	FLIPT1\|PRO34686
	Cytomap	1p31.3	1p13.1
	Type of gene	protein-coding	protein-coding
	Description	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseMan(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferaseasparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)asparagine-linked glycosylation 6 homolog (yeast	solute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like protein
	Modification date	20200313	20200313
	UniProtAcc	Q9Y672	.
	Ensembl transtripts involved in fusion gene	ENST00000263440, ENST00000371108, ENST00000494765,	ENST00000481127, ENST00000369502, ENST00000369503,
Fusion gene scores	* DoF score	10 X 8 X 6=480	5 X 4 X 4=80
	# samples	10	5
	** MAII score	log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ALG6 [Title/Abstract] AND SLC22A15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ALG6(63836730)-SLC22A15(116569514), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALG6	GO:0006487	protein N-linked glycosylation	10924277

Fusion gene breakpoints across ALG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC22A15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EB-A44R-06A	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+

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Fusion Gene ORF analysis for ALG6-SLC22A15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263440	ENST00000481127	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
5CDS-intron	ENST00000371108	ENST00000481127	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
In-frame	ENST00000263440	ENST00000369502	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
In-frame	ENST00000263440	ENST00000369503	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
In-frame	ENST00000371108	ENST00000369502	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
In-frame	ENST00000371108	ENST00000369503	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
intron-3CDS	ENST00000494765	ENST00000369502	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
intron-3CDS	ENST00000494765	ENST00000369503	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+
intron-intron	ENST00000494765	ENST00000481127	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371108	ALG6	chr1	63836730	-	ENST00000369503	SLC22A15	chr1	116569514	+	4379	387	305	1432	375
ENST00000371108	ALG6	chr1	63836730	-	ENST00000369502	SLC22A15	chr1	116569514	+	1005	387	305	526	73
ENST00000263440	ALG6	chr1	63836730	-	ENST00000369503	SLC22A15	chr1	116569514	+	4282	290	208	1335	375
ENST00000263440	ALG6	chr1	63836730	-	ENST00000369502	SLC22A15	chr1	116569514	+	908	290	208	429	73

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371108	ENST00000369503	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+	0.003186337	0.9968137
ENST00000371108	ENST00000369502	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+	0.1547654	0.84523463
ENST00000263440	ENST00000369503	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+	0.003297908	0.99670213
ENST00000263440	ENST00000369502	ALG6	chr1	63836730	-	SLC22A15	chr1	116569514	+	0.21381518	0.78618485

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Fusion Genomic Features for ALG6-SLC22A15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ALG6-SLC22A15

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:63836730/chr1:116569514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ALG6 Q9Y672	.
FUNCTION: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

4_24

508.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

529_535

199

246.0

Compositional bias

Note=Poly-Glu

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

529_535

199

548.0

Compositional bias

Note=Poly-Glu

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

201_221

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

226_246

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

303_323

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

338_358

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

368_388

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

401_420

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

433_453

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

462_482

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

201_221

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

226_246

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

303_323

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

338_358

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

368_388

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

401_420

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

433_453

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

462_482

199

548.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

115_135

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

144_164

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

173_193

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

227_247

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

298_318

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

324_344

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

362_382

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

388_408

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

438_458

508.0

Transmembrane

Helical

Hgene

ALG6

chr1:63836730

chr1:116569514

ENST00000371108

473_493

508.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

111_131

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

141_161

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

165_187

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369502

22_42

199

246.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

111_131

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

141_161

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

165_187

199

548.0

Transmembrane

Helical

Tgene

SLC22A15

chr1:63836730

chr1:116569514

ENST00000369503

22_42

199

548.0

Transmembrane

Helical

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Fusion Gene Sequence for ALG6-SLC22A15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>4032_4032_1_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369502_length(transcript)=908nt_BP=290nt
GGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGAAGAATCG
ATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTGCTGTGTT
TTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGATGGACAGT
GTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTC
CTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTGGTCGACTGAGTGAGGCTGAAGAGGCGCTG
TACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTC
CTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTAATTATACTAAGGCGTGTTCTGTTGCTCT
TTAACTAAGGTTGCTCGAGCTTCTCTTGATATCCTGCTCCTTCTTCAGGGTACAGGGAATTTTACCTCTTTTGTTAGCTTGAGGTTGTTT
TCTCAACAGCAAGTCTCCTGATCCTTAGCGCCTGGTTTTCTGCTTGCGCAGCCCCGTCTTTCTCAAGTAGCAGATGATAGTGCCTGATGG
GCAGGTCCACTGAGCTTGAGTAAGTAGACATCAGAAGCACATCTTTGCTTTTGAGGTATTTATCATAAATATTTAAGCCTTCCTGCCCCT

>4032_4032_1_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369502_length(amino acids)=73AA_BP=21

--------------------------------------------------------------
>4032_4032_2_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369503_length(transcript)=4282nt_BP=290nt
GGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGAAGAATCG
ATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTGCTGTGTT
TTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGATGGACAGT
GTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTC
CTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTTGGTTATA
CTCCCAGGGTCGACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACA
CCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTT
CATCTGGTTTGTGTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGGCCCTGTC
TGGCCTCATAGAGATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAGCATTTCT
GTGCCTAGGAGGACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGACACAGGTGTGTTTGCAGTGGTGAACAGCCATTCCTT
GTCCTTGCTGGGGAAGCTGACCATCAGTGCTGCCTTTAACATTGTTTATATCTACACCTCTGAGCTTTACCCTACAGTCATCAGGAATGT
TGGGCTTGGAACTTGTTCCATGTTCTCCCGAGTTGGTGGGATTATTGCTCCCTTCATCCCCTCACTGAAATATGTGCAATGGTCTTTACC
ATTCATTGTCTTCGGAGCCACGGGTCTGACCTCCGGCCTCCTGAGTTTGTTATTGCCGGAGACCCTTAACAGTCCGCTGCTAGAAACATT
CTCCGACCTTCAGGTGTATTCGTATCGCAGGCTGGGAGAAGAAGCATTATCTTTACAGGCTTTGGACCCCCAACAGTGTGTGGACAAGGA
GAGCTCTTTAGGGAGTGAGAGTGAGGAAGAGGAAGAATTTTATGATGCAGATGAAGAGACTCAGATGATCAAGTGAAGAGCCCCAGATTC
CCCCTAAGAAGCAAAGGATCGTCTTTTATGCCTCTGGCTAAGGCAGGTTCTTCCATGACTCCTAAGAGAGTTGTAAAAATAGAGGCTTGG
CTTGAATGTACATAGATGGTACCTGGCATGGACTGATGTTTTTAGGCACAGAAGTTGGAGAAGAGATTTCATGAAAGACAACATCACTGC
ATTGAGAGAATAGTTGTTAATTTGTTTAGAATTTAAGTTCTACTCAGAATCATAACATCTGGCAGAACAGCCCAAACCCACATTCCAAAG
TGGTAGGCTCATTTGTTTCTAGAGATTTCATCATGTCGCTTTTCCTTCATCATGATCTAAATAAAGGCAGATATGTAAAATTTCTCACCA
TTTTGGTGGGGTAAGATAAGCTATTATTAAGATTTAATCCTTATACCATGTTGGACATTTGCCCCTATCAGTTGCTCCTCAGGAATCTTC
TGGTACAGGTTAACATCAGCATTTTCATTTTGTGTCCAGGGAAAAGCACCCAGAGGTCATCTGTGTGTCCCGAGACCCTCCAGCTTTTTC
TTAGCTGATGAAATATGAGTCCTCAGCTTGGTTCCCAGCCTGCTGATTGACTTGGGCTGCTGGTGCCTTGAGTCCCACAGATGATTCATT
AGGAAAAGCCAGATATACCAAAGCGGTTTACTCAGAGTCAGGGGTGTAGCTCTGGCTGCCTGTCAGCTCCCTTGGATACTATATTGTATG
ATTTCTTCCTTTCCCACTAATATGCACATCCAGAAAAATTTCCATCTGAGATTCTAGTACTTCAAAATCATGCATAGTAAATGAGAAAGC
TTTAAGTAGAGGGCAGTTAAACAGTGACATGTTGAGCACCTGGAGGAAAAAAAAGGTGCAGTTTTTAATAAGAGAGAAAATGAAATTATC
TTTGATAAATTTTTGTTTGTTTTGCTTTCAGCATTGTGCCATGAGGGATTTGGACAATATTTAAGAACTTCTTGTCCTAGATCAGCCCCA
ATCTGTTTAATCAAAATGGAAGGTTCAGTAATTTCATGGGAAACCTTGGTTTTTCATTAAGTGCTACCAACTTTCAAGTGAATCTTGTAT
TTGATTTCCTAAAATCATGTCTTGAAAACATGTTTTCTCATGAAACTTGAATACTATCTCAAATAGGAATATAAACCTGGAGTCAACAAG
CTTAGGCAGCATTGATTTAGGTCACTTTCCCAGTGAGGAAAATTTCTGTGTTTTCAGAATTTCCATTTCTACTAACCTCTTGGAGAAAAA
GAAATTGAATTAGAGGTAAATAGAAGACGTCACTGTGGCTGCTTCTGGAAGTGCTGGAAGCATCACCCCAATTGGCTCCAAATACTGTCA
TGTTTTCTTGCACACTGACTTCTGGTTTCCACTGTATCAGTATGTACCTTTGTAATTGTTATTTTTATGTCTTTTATGCCCTTGATTATT
AGTTGGGCTCTTCATAAACAGAGGCCATCTCTACTACTGTTTATTTTTCCCTGCTGTGCCCAGAACATTGGCGTAGACACAGTAAGAACC
TAGTAAATATTACTGTTTCTAGCCATCAGGGAGATTGTGGAACTCCTCCCAGTATAATTTTTACAAACTCCAAGCAAATCTGACCCAAAC
TCCCAAATTGTCAAGTCCTGCTTAACTTTCTCTGGAAAATAGACCCCTTCTCAACATCAGAATAGGAAGAGAGGAAGAACTTACAAAGAC
ACTTAAAAGTTATTCTTAAATGGTGGTTGGGCATTTAAAACAGTGAACTAACATATATATAATTTTTGATTAGTTGGAGCTTTCTTTGTA
TTATAAGAGTAATATATCTCATTACAGAAAATTTGGAAACTATAAATTTAGAAACGTATCACCCATACGTCCAACATCGAAAGAAAACCA
GTGTTATGACTTTGTTCCATTTGAAGACTAATTGGGAGTCCATCTCTCTATTGGCACTGGGTTCGATTGCCTCTGGCTAATAGAGTTCAA
TTAGTTCTATCCCTGGGTTTCCTTTCTTAGCTATGGGGTGGAAGATAGGAGGGGGAGATCTACAATTTGAATATGTGTTACTTAATAAGG
CTAGGCTGGCCATCAGTTGCTTATTTCAGATGTGTCACTAAATTTTCCTTCTAGATGGTCCTTGAGCAAAACTTAATAATTACTGTTTTT
TATTTCCACTGCCTTTATAAAATCAAAATTTTCTCCTTTTGATAAAAACTGTTGAATACTATTGATGTAGAGAATGTGTATATGTGTATA
TTTGCATTGATTAAATTATTGGAAAACTTTTCATTGACAGGTAATGTATTTTGGTTGTGCGGATGGTTTGTAAAAAGTATCCTGTTTTTT
TAATTCTATTCAAAATTAAAAATTTTTTTTCCTAAAATAAAGCAAGAAAAATAAATGTAAGATATATAAGAAACCCCAGAGTTTCCAGGG
TGAAAGTTCACATTAGCAGCTTGTCCAAAATATTTACACCTCACAAATATTTTGAAAGAAACCATGTTGAAATTTTCTGATTTTGTGAGT
TACAACCACAGCCCAGTAAAACCAATACTTGTTATTTGGCTACTTTCAAGCAATGCAGATATTCTTTAGTATTTAAAAATGAGCAAATAA
ACAAAATGAGGCAAATAAATGAAGAAAATGAGTTTCTGAGACACTGTTTAGGTAACCATAAATCAGACAGATATTTTTATGGTGGGCAAA
TTGATGAAGATACTTTTAGTAGGTGATTTATATTCATAACAAATACATATTGAAATAATTGTCACTACTGTATCAGAATTAAAAACCAGC
TTCACATTAGGACTTCTCCATACAAATGCTTTATCATTGGTTCTTAAATTGGAAAAATATCTATAAATGATTACATTTTTAAGCTAAATA

>4032_4032_2_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000263440_SLC22A15_chr1_116569514_ENST00000369503_length(amino acids)=375AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAE
EALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP
LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS
RVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEE

--------------------------------------------------------------
>4032_4032_3_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369502_length(transcript)=1005nt_BP=387nt
CGGAAGGCCGGAGGGGCAGTCCGCCGCGGGGGCGAGCGCGCATGCGCCTTCCTGGGACCCACGGCAGGCGCGAATCCCAGCGGCCGGCGG
GCGGCGGGGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGA
AGAATCGATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTG
CTGTGTTTTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGAT
GGACAGTGTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCA
TCCGCTCCTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTGGTCGACTGAGTGAGGCTGAAGA
GGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGG
AAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTAATTATACTAAGGCGTGTTCTG
TTGCTCTTTAACTAAGGTTGCTCGAGCTTCTCTTGATATCCTGCTCCTTCTTCAGGGTACAGGGAATTTTACCTCTTTTGTTAGCTTGAG
GTTGTTTTCTCAACAGCAAGTCTCCTGATCCTTAGCGCCTGGTTTTCTGCTTGCGCAGCCCCGTCTTTCTCAAGTAGCAGATGATAGTGC
CTGATGGGCAGGTCCACTGAGCTTGAGTAAGTAGACATCAGAAGCACATCTTTGCTTTTGAGGTATTTATCATAAATATTTAAGCCTTCC

>4032_4032_3_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369502_length(amino acids)=73AA_BP=21

--------------------------------------------------------------
>4032_4032_4_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369503_length(transcript)=4379nt_BP=387nt
CGGAAGGCCGGAGGGGCAGTCCGCCGCGGGGGCGAGCGCGCATGCGCCTTCCTGGGACCCACGGCAGGCGCGAATCCCAGCGGCCGGCGG
GCGGCGGGGATACTTCTACATAGACATAATCAAGTTTTGACTATTTGGAAACCAAGCATCATTAAAATTCTCTCAAACTCCTAATTGCGA
AGAATCGATAACATTTCAAGAAGTGATAACATTTCTCTGAACAAGAAAAGAAGTGATTGACCACGTTTTAAAAGTACTCTGGCACTGGTG
CTGTGTTTTCTTCCCCTCCCTAAATTTGAAGAACTATGGAGAAATGGTACTTGATGACAGTAGTGGTTTTAATAGGACTAACAGTACGAT
GGACAGTGTCTCTTAATTCTTATTCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCA
TCCGCTCCTGGAGGACCCTAGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTT
GGTTATACTCCCAGGGTCGACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCAC
TAACACACCCAGCCAACAGGAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCC
TGATGTTCATCTGGTTTGTGTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGG
CCCTGTCTGGCCTCATAGAGATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAG
CATTTCTGTGCCTAGGAGGACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGACACAGGTGTGTTTGCAGTGGTGAACAGCC
ATTCCTTGTCCTTGCTGGGGAAGCTGACCATCAGTGCTGCCTTTAACATTGTTTATATCTACACCTCTGAGCTTTACCCTACAGTCATCA
GGAATGTTGGGCTTGGAACTTGTTCCATGTTCTCCCGAGTTGGTGGGATTATTGCTCCCTTCATCCCCTCACTGAAATATGTGCAATGGT
CTTTACCATTCATTGTCTTCGGAGCCACGGGTCTGACCTCCGGCCTCCTGAGTTTGTTATTGCCGGAGACCCTTAACAGTCCGCTGCTAG
AAACATTCTCCGACCTTCAGGTGTATTCGTATCGCAGGCTGGGAGAAGAAGCATTATCTTTACAGGCTTTGGACCCCCAACAGTGTGTGG
ACAAGGAGAGCTCTTTAGGGAGTGAGAGTGAGGAAGAGGAAGAATTTTATGATGCAGATGAAGAGACTCAGATGATCAAGTGAAGAGCCC
CAGATTCCCCCTAAGAAGCAAAGGATCGTCTTTTATGCCTCTGGCTAAGGCAGGTTCTTCCATGACTCCTAAGAGAGTTGTAAAAATAGA
GGCTTGGCTTGAATGTACATAGATGGTACCTGGCATGGACTGATGTTTTTAGGCACAGAAGTTGGAGAAGAGATTTCATGAAAGACAACA
TCACTGCATTGAGAGAATAGTTGTTAATTTGTTTAGAATTTAAGTTCTACTCAGAATCATAACATCTGGCAGAACAGCCCAAACCCACAT
TCCAAAGTGGTAGGCTCATTTGTTTCTAGAGATTTCATCATGTCGCTTTTCCTTCATCATGATCTAAATAAAGGCAGATATGTAAAATTT
CTCACCATTTTGGTGGGGTAAGATAAGCTATTATTAAGATTTAATCCTTATACCATGTTGGACATTTGCCCCTATCAGTTGCTCCTCAGG
AATCTTCTGGTACAGGTTAACATCAGCATTTTCATTTTGTGTCCAGGGAAAAGCACCCAGAGGTCATCTGTGTGTCCCGAGACCCTCCAG
CTTTTTCTTAGCTGATGAAATATGAGTCCTCAGCTTGGTTCCCAGCCTGCTGATTGACTTGGGCTGCTGGTGCCTTGAGTCCCACAGATG
ATTCATTAGGAAAAGCCAGATATACCAAAGCGGTTTACTCAGAGTCAGGGGTGTAGCTCTGGCTGCCTGTCAGCTCCCTTGGATACTATA
TTGTATGATTTCTTCCTTTCCCACTAATATGCACATCCAGAAAAATTTCCATCTGAGATTCTAGTACTTCAAAATCATGCATAGTAAATG
AGAAAGCTTTAAGTAGAGGGCAGTTAAACAGTGACATGTTGAGCACCTGGAGGAAAAAAAAGGTGCAGTTTTTAATAAGAGAGAAAATGA
AATTATCTTTGATAAATTTTTGTTTGTTTTGCTTTCAGCATTGTGCCATGAGGGATTTGGACAATATTTAAGAACTTCTTGTCCTAGATC
AGCCCCAATCTGTTTAATCAAAATGGAAGGTTCAGTAATTTCATGGGAAACCTTGGTTTTTCATTAAGTGCTACCAACTTTCAAGTGAAT
CTTGTATTTGATTTCCTAAAATCATGTCTTGAAAACATGTTTTCTCATGAAACTTGAATACTATCTCAAATAGGAATATAAACCTGGAGT
CAACAAGCTTAGGCAGCATTGATTTAGGTCACTTTCCCAGTGAGGAAAATTTCTGTGTTTTCAGAATTTCCATTTCTACTAACCTCTTGG
AGAAAAAGAAATTGAATTAGAGGTAAATAGAAGACGTCACTGTGGCTGCTTCTGGAAGTGCTGGAAGCATCACCCCAATTGGCTCCAAAT
ACTGTCATGTTTTCTTGCACACTGACTTCTGGTTTCCACTGTATCAGTATGTACCTTTGTAATTGTTATTTTTATGTCTTTTATGCCCTT
GATTATTAGTTGGGCTCTTCATAAACAGAGGCCATCTCTACTACTGTTTATTTTTCCCTGCTGTGCCCAGAACATTGGCGTAGACACAGT
AAGAACCTAGTAAATATTACTGTTTCTAGCCATCAGGGAGATTGTGGAACTCCTCCCAGTATAATTTTTACAAACTCCAAGCAAATCTGA
CCCAAACTCCCAAATTGTCAAGTCCTGCTTAACTTTCTCTGGAAAATAGACCCCTTCTCAACATCAGAATAGGAAGAGAGGAAGAACTTA
CAAAGACACTTAAAAGTTATTCTTAAATGGTGGTTGGGCATTTAAAACAGTGAACTAACATATATATAATTTTTGATTAGTTGGAGCTTT
CTTTGTATTATAAGAGTAATATATCTCATTACAGAAAATTTGGAAACTATAAATTTAGAAACGTATCACCCATACGTCCAACATCGAAAG
AAAACCAGTGTTATGACTTTGTTCCATTTGAAGACTAATTGGGAGTCCATCTCTCTATTGGCACTGGGTTCGATTGCCTCTGGCTAATAG
AGTTCAATTAGTTCTATCCCTGGGTTTCCTTTCTTAGCTATGGGGTGGAAGATAGGAGGGGGAGATCTACAATTTGAATATGTGTTACTT
AATAAGGCTAGGCTGGCCATCAGTTGCTTATTTCAGATGTGTCACTAAATTTTCCTTCTAGATGGTCCTTGAGCAAAACTTAATAATTAC
TGTTTTTTATTTCCACTGCCTTTATAAAATCAAAATTTTCTCCTTTTGATAAAAACTGTTGAATACTATTGATGTAGAGAATGTGTATAT
GTGTATATTTGCATTGATTAAATTATTGGAAAACTTTTCATTGACAGGTAATGTATTTTGGTTGTGCGGATGGTTTGTAAAAAGTATCCT
GTTTTTTTAATTCTATTCAAAATTAAAAATTTTTTTTCCTAAAATAAAGCAAGAAAAATAAATGTAAGATATATAAGAAACCCCAGAGTT
TCCAGGGTGAAAGTTCACATTAGCAGCTTGTCCAAAATATTTACACCTCACAAATATTTTGAAAGAAACCATGTTGAAATTTTCTGATTT
TGTGAGTTACAACCACAGCCCAGTAAAACCAATACTTGTTATTTGGCTACTTTCAAGCAATGCAGATATTCTTTAGTATTTAAAAATGAG
CAAATAAACAAAATGAGGCAAATAAATGAAGAAAATGAGTTTCTGAGACACTGTTTAGGTAACCATAAATCAGACAGATATTTTTATGGT
GGGCAAATTGATGAAGATACTTTTAGTAGGTGATTTATATTCATAACAAATACATATTGAAATAATTGTCACTACTGTATCAGAATTAAA
AACCAGCTTCACATTAGGACTTCTCCATACAAATGCTTTATCATTGGTTCTTAAATTGGAAAAATATCTATAAATGATTACATTTTTAAG

>4032_4032_4_ALG6-SLC22A15_ALG6_chr1_63836730_ENST00000371108_SLC22A15_chr1_116569514_ENST00000369503_length(amino acids)=375AA_BP=21
MEKWYLMTVVVLIGLTVRWTVSLNSYSGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAE
EALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP
LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS
RVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ALG6-SLC22A15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ALG6-SLC22A15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ALG6-SLC22A15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source