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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IST1-RBL2 (FusionGDB2 ID:40334)

Fusion Gene Summary for IST1-RBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: IST1-RBL2
Fusion gene ID: 40334
HgeneTgene
Gene symbol

IST1

RBL2

Gene ID

9798

5934

Gene nameIST1 factor associated with ESCRT-IIIRB transcriptional corepressor like 2
SynonymsCHMP8|OLC1P130|Rb2
Cytomap

16q22.2

16q12.2

Type of geneprotein-codingprotein-coding
DescriptionIST1 homologIST1, ESCRT-III associated factorIST1, endosomal sorting complex required for transport-III componentincreased sodium tolerance 1 homologoverexpressed in lung cancer 1putative MAPK-activating protein PM28retinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2
Modification date2020031320200320
UniProtAcc

P53990

.
Ensembl transtripts involved in fusion geneENST00000538565, ENST00000329908, 
ENST00000378798, ENST00000378799, 
ENST00000535424, ENST00000538850, 
ENST00000541571, ENST00000544564, 
ENST00000606369, 		ENST00000262133, 
ENST00000379935, ENST00000544545, 
Fusion gene scores* DoF score12 X 6 X 4=2887 X 6 X 4=168
# samples 137
** MAII scorelog2(13/288*10)=-1.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IST1 [Title/Abstract] AND RBL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIST1(71956583)-RBL2(53493362), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIST1

GO:0009838

abscission

19129479|19129480

HgeneIST1

GO:0019076

viral release from host cell

19129479

HgeneIST1

GO:0045862

positive regulation of proteolysis

20849418

HgeneIST1

GO:0046745

viral capsid secondary envelopment

19129479

TgeneRBL2

GO:0043550

regulation of lipid kinase activity

16286473


check buttonFusion gene breakpoints across IST1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A893IST1chr16

71956583

+RBL2chr16

53493362

+


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Fusion Gene ORF analysis for IST1-RBL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538565ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
3UTR-3UTRENST00000538565ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
3UTR-3UTRENST00000538565ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000329908ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000329908ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000378798ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000378798ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000378799ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000378799ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000535424ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000535424ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000538850ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000538850ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000541571ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000541571ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000544564ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000544564ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000606369ENST00000379935IST1chr16

71956583

+RBL2chr16

53493362

+
5CDS-3UTRENST00000606369ENST00000544545IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000329908ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000378798ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000378799ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000535424ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000538850ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000541571ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000544564ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+
In-frameENST00000606369ENST00000262133IST1chr16

71956583

+RBL2chr16

53493362

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544564IST1chr1671956583+ENST00000262133RBL2chr1653493362+4671108128333211012
ENST00000541571IST1chr1671956583+ENST00000262133RBL2chr1653493362+5050146066237001012
ENST00000535424IST1chr1671956583+ENST00000262133RBL2chr1653493362+450491411631541012
ENST00000378799IST1chr1671956583+ENST00000262133RBL2chr1653493362+470511153563355999
ENST00000606369IST1chr1671956583+ENST00000262133RBL2chr1653493362+3967377622617851
ENST00000329908IST1chr1671956583+ENST00000262133RBL2chr1653493362+4411821623061999
ENST00000538850IST1chr1671956583+ENST00000262133RBL2chr1653493362+40344441292684851
ENST00000378798IST1chr1671956583+ENST00000262133RBL2chr1653493362+4401811523051999

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544564ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0003728040.99962723
ENST00000541571ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0007073690.9992926
ENST00000535424ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0003278870.9996722
ENST00000378799ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0002195440.9997805
ENST00000606369ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0001841580.9998159
ENST00000329908ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0001525120.9998474
ENST00000538850ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0002117230.99978834
ENST00000378798ENST00000262133IST1chr1671956583+RBL2chr1653493362+0.0001477710.9998522

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Fusion Genomic Features for IST1-RBL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IST1chr1671956583+RBL2chr1653493362+2.24E-081
IST1chr1671956583+RBL2chr1653493362+2.24E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IST1-RBL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:71956583/chr16:53493362)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IST1

P53990

.
FUNCTION: ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBL2chr16:71956583chr16:53493362ENST00000262133722998_10013931140.0Compositional biasNote=Poly-Glu
TgeneRBL2chr16:71956583chr16:53493362ENST00000262133722417_10243931140.0RegionNote=Pocket%3B binds E1A
TgeneRBL2chr16:71956583chr16:53493362ENST00000262133722417_6163931140.0RegionNote=Domain A
TgeneRBL2chr16:71956583chr16:53493362ENST00000262133722617_8273931140.0RegionNote=Spacer
TgeneRBL2chr16:71956583chr16:53493362ENST00000262133722828_10243931140.0RegionNote=Domain B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+710321_332253361.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+710351_361253361.0MotifNote=MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+79321_332253336.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+79351_361253336.0MotifNote=MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+710321_332253367.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+710351_361253367.0MotifNote=MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+710321_332266380.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+710351_361266380.0MotifNote=MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+811321_332253367.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+811351_361253367.0MotifNote=MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+912321_332253367.0MotifNote=Type-2 MIT-interacting motif
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+912351_361253367.0MotifNote=MIT-interacting motif
TgeneRBL2chr16:71956583chr16:53493362ENST0000026213372217_203931140.0Compositional biasNote=Poly-Ala
TgeneRBL2chr16:71956583chr16:53493362ENST0000026213372223_263931140.0Compositional biasNote=Poly-Glu
TgeneRBL2chr16:71956583chr16:53493362ENST000002621337229_163931140.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for IST1-RBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40334_40334_1_IST1-RBL2_IST1_chr16_71956583_ENST00000329908_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4411nt_BP=821nt
GAACCCTGAAGTCGGTGTCTGCTGCGTTCACGGCAGGATTCGGTTAGGAGGAACAGCACAGCATGCTGGGCTCTGGATTTAAAGCTGAGC
GCTTAAGAGTGAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAACTGGCCCAGAAAGCAAGGAAGGAGA
TTGCTGACTATCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGGAAGACTACCTCGTGGAGGCCATGG
AGATCCTGGAGCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAACTAGATTCTGGTCTGGCTGAATCTG
TGTCTACATTGATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCAAGTATAGCA
AGGAATATGGCAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCCCACCCAAAA
TCCTGGTGGAGAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCTCCTG
GGGTAGAGACAGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCACAGCAC
CAGTTGGTGGACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATCCACTGC
CAAAGGGACCATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAGTTT
CTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGA
CATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGGATT
TCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGG
AACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGGTCG
TCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAG
TATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCATGGA
AACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGGAAA
GGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCA
TAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCCCCT
CTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCA
CACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAGGTA
TTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCC
TCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAACAGA
TTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCT
TTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCTGGA
CCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGG
CAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAAGTG
TTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATA
GAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTCGCC
TCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACAT
TTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATACAGT
TGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACA
GTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATGGAA
GTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCCACT
GAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAATCC
AGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTTA
ATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCTGGCAAA
GCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTT
CAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGGTAG
GAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCTTTG
TGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTGTATAAG
TGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTA
TTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCCACCTTT
TGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATTAAT
ATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTGTTC
CTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAACAGC
TGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATTCAATTG
TAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTC
TGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTTTCAATAAAGCATTTATAAATTA

>40334_40334_1_IST1-RBL2_IST1_chr16_71956583_ENST00000329908_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=999AA_BP=253
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMK
ELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKALRISTPLTGVRYIK
ENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYY
KVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIE
EQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRR
RLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQA
QAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDI
SDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQ
NSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFV
RTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQ

--------------------------------------------------------------
>40334_40334_2_IST1-RBL2_IST1_chr16_71956583_ENST00000378798_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4401nt_BP=811nt
GTCGGTGTCTGCTGCGTTCACGGCAGGATTCGGTTAGGAGGAACAGCACAGCATGCTGGGCTCTGGATTTAAAGCTGAGCGCTTAAGAGT
GAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAACTGGCCCAGAAAGCAAGGAAGGAGATTGCTGACTA
TCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGGAAGACTACCTCGTGGAGGCCATGGAGATCCTGGA
GCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAACTAGATTCTGGTCTGGCTGAATCTGTGTCTACATT
GATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCAAGTATAGCAAGGAATATGG
CAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCCCACCCAAAATCCTGGTGGA
GAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCTCCTGGGGTAGAGAC
AGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCACAGCACCAGTTGGTGG
ACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATCCACTGCCAAAGGGACC
ATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAGTTTCTACAGCTAC
GCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGACATGTTCCAG
AGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGGATTTCAGTAATTG
TGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGGAACAAAAAAG
ACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTC
TTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAGTATTCATTAG
AGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCATGGAAACCAGAGTC
TCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGGAAAGGGCAGATGA
AATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCATAACATCTCC
AACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCCCCTCTGATGGAGG
GACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCACACCAGTTCC
TGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAGGTATTGCCAATGA
AAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCA
GGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAACAGATTTCCCCAGG
TGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGT
ATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCTGGACCTGCTTTGA
ATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGGCAAAGGTCAC
AAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAA
AGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATAGAACCAGTAG
AGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTCGCCTCACAGGTGC
CAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACATTTGCCATGAA
GTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAA
TCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACAGTCCTTCAAA
GAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATGGAAGTGAATCACC
TGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCCACTGAGGTTAGTC
TCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAATCCAGCTGATGAG
TTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTTAATTCATCCCA
ACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCTGGCAAAGCTTTTAGAA
ATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTTCAAGTTCAAT
CCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGGTAGGAGTGTGTGA
TTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCTTTGTGCACATCTT
CCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTGTATAAGTGGAGGCACT
TTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTATTAAATACAA
AACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCCACCTTTTGGGAATGTT
TTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATTAATATGAAAACTT
ATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTT
AAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAACAGCTGAATTATCT
ATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATTCAATTGTAAATTGAAT
CAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTCTGCAAAAATA

>40334_40334_2_IST1-RBL2_IST1_chr16_71956583_ENST00000378798_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=999AA_BP=253
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMK
ELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKALRISTPLTGVRYIK
ENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYY
KVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIE
EQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRR
RLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQA
QAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDI
SDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQ
NSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFV
RTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQ

--------------------------------------------------------------
>40334_40334_3_IST1-RBL2_IST1_chr16_71956583_ENST00000378799_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4705nt_BP=1115nt
CTGTGGCTGGCCTCCCCGCGCCCAGAGCGAAATTAAGGGCATGCCCCCAGCAGCTGACTCAGTCGGCGTGGCGCTTCCCCCAACGTCTGC
CGTGCCCCCGCCGCGGGAAGTAGTCCCCGGCCGCGCCGACTCCAAAGGAAACCGAGGGAGGGTGCCCCGAGTCAGCGCGTGGGTCCCGGC
AGCGGCGATCGCGCAGCCAATCCCTGGAAAGGAGGGCGTGGCTATATCGGCCCCGTGGATCCCTCCGCCCGCGCTTGTTGTGCTGAGGCC
GAGGGAGTCGCCATTTTGGATGGTGAACCCTGAAGTCGGTGTCTGCTGCGTTCACGGCAGGATTCGGTTAGGAGGAACAGCACAGCATGC
TGGGCTCTGGATTTAAAGCTGAGCGCTTAAGAGTGAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAAC
TGGCCCAGAAAGCAAGGAAGGAGATTGCTGACTATCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGG
AAGACTACCTCGTGGAGGCCATGGAGATCCTGGAGCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAAC
TAGATTCTGGTCTGGCTGAATCTGTGTCTACATTGATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTG
ATCAGCTCTGTGCCAAGTATAGCAAGGAATATGGCAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGC
TGAGTGTGGAAGCCCCACCCAAAATCCTGGTGGAGAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTG
TGGTCATGGCAGAAGCTCCTCCTGGGGTAGAGACAGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAG
GAGGGAGTGGTGGCTTCACAGCACCAGTTGGTGGACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAA
ATACGCCTTTCTCATATCCACTGCCAAAGGGACCATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGA
ATAGCCCTTGTGTGACTCCAGTTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTG
AGAAACTGGAACAGATTCTCAGGACATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTC
AGCATTTCCAGCCAGACGAGGATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAG
TATTAGAATCTGTTATTGAGCAGGAACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTC
TCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTT
ATCATTTTTATAAGGTGATAGAAGTATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAAC
AGATCTTAGATCATTTGGCATGGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGG
TCATGCCACCTCAGAACCTGGAAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTG
ATACTGGAGGACTTGGAAGGAGCATAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGC
TATTTGTTGAGAATGATAGCCCCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATG
TATCTGGGGAGACTGTTTCTGTCACACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAA
CGGTAACCATTCCTGTGCAAGGTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAG
CTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCC
CTGGTCAAGTGGCCATTCAACAGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGA
AGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAG
ATGAATTGAGGAAAAAAATCTGGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTAT
TAATGTGTGCCATTTATGTGATGGCAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGG
CCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATT
CTCCAACAGAACTAAACAAAGATAGAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCA
GTGCTCCTCCCACACCTACTCGCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACA
TCTACATCAAACAGATTAAGACATTTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAA
CAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAA
AGATTTTCTATTACTTCAGCAACAGTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGA
GAGGAATTCTTTTGGAAGATGGAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATG
TAGCTAATGACCGTGGTTCCCACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGA
TTATGGAGCTTTTTTCCTTAATCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCC
TTCCAGTGTCCTTAGAACATTTTAATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAA
ACTTGGATTTTTGACTCTGGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACG
TACTCCAACAGAAGAACTGTGTTTCAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGT
ATTTTGTCCTAAAACACCTGGTAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATT
AGCCCTCGTCTCCCGTTCCCTTTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGC
AATGTCTGAGTGAACCTGTATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATA
GCACTTTCTACAATGTGAACTTTATTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAAT
GTTAAAACCCCTATAGCCACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAA
TCAAGTTGAATTGAGGGGATTAATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATAT
ATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACA
AATTAGAAAATGTTATTTAACAGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAAT
CTTATTAGGGAGAAAATTCAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTA
CATTGTTCAATTAGAATAGTGTTCTGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATT

>40334_40334_3_IST1-RBL2_IST1_chr16_71956583_ENST00000378799_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=999AA_BP=253
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMK
ELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKALRISTPLTGVRYIK
ENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYY
KVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIE
EQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRR
RLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQA
QAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDI
SDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQ
NSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFV
RTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQ

--------------------------------------------------------------
>40334_40334_4_IST1-RBL2_IST1_chr16_71956583_ENST00000535424_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4504nt_BP=914nt
AGCGATGCGGTTTCACTATGGTGTCCAGGCTGGTCTGCAACTCCCGGGCTCAAGCGATCCTCCCGCCCCGCCTCTCAAAGTGCTGGGAAG
GTCCCTTCCAGGCTTAAGCAGCGATAATGGTTTTCAAGTTAAAAACAAAGGAGGAACAGCACAGCATGCTGGGCTCTGGATTTAAAGCTG
AGCGCTTAAGAGTGAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAACTGGCCCAGAAAGCAAGGAAGG
AGATTGCTGACTATCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGGAAGACTACCTCGTGGAGGCCA
TGGAGATCCTGGAGCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAACTAGATTCTGGTCTGGCTGAAT
CTGTGTCTACATTGATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCAAGTATA
GCAAGGAATATGGCAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCCCACCCA
AAATCCTGGTGGAGAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCTC
CTGGGGTAGAGACAGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCACAG
CACCAGTTGGTGGACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATCCAC
TGCCAAAGGGACCATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAG
TTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCA
GGACATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGG
ATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGC
AGGAACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGG
TCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAG
AAGTATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCAT
GGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGG
AAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGA
GCATAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCC
CCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTG
TCACACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAG
GTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGC
CCCTCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAAC
AGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTT
TCTTTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCT
GGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGA
TGGCAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAA
GTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAG
ATAGAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTC
GCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGA
CATTTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATAC
AGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCA
ACAGTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATG
GAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCC
ACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAA
TCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATT
TTAATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCTGGC
AAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTG
TTTCAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGG
TAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCT
TTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTGTAT
AAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACT
TTATTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCCACC
TTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATT
AATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTG
TTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAAC
AGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATTCAA
TTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTG
TTCTGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTTTCAATAAAGCATTTATAAA

>40334_40334_4_IST1-RBL2_IST1_chr16_71956583_ENST00000535424_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=1012AA_BP=266
MVFKLKTKEEQHSMLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCD
LLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI
EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKAL
RISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEI
ASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDG
LCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLY
DRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGI
TFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLA
AVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRK
RRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQA
NMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRI

--------------------------------------------------------------
>40334_40334_5_IST1-RBL2_IST1_chr16_71956583_ENST00000538850_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4034nt_BP=444nt
CTGAAGTCGGTGTCTGCTGCGTTCACGGCAGGATTCGGTTAGGTTGCTGATCAGCTCTGTGCCAAGTATAGCAAGGAATATGGCAAGCTA
TGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCCCACCCAAAATCCTGGTGGAGAGATAC
CTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCTCCTGGGGTAGAGACAGATCTT
ATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCACAGCACCAGTTGGTGGACCTGAT
GGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATCCACTGCCAAAGGGACCATCCAAA
GCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAGTTTCTACAGCTACGCATAGC
TTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGACATGTTCCAGAGATCCA
ACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGGATTTCAGTAATTGTGCTAAA
GAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGGAACAAAAAAGACTAGGA
GACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTCTTATAAG
CCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAGTATTCATTAGAGCAGAA
GATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCATGGAAACCAGAGTCTCCACTC
TGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGGAAAGGGCAGATGAAATTTGC
ATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCATAACATCTCCAACCACA
TTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCCCCTCTGATGGAGGGACGCCT
GGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCACACCAGTTCCTGGACAG
ACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAGGTATTGCCAATGAAAATGGA
GGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCAGGCCCTG
GCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAACAGATTTCCCCAGGTGGCCAA
CAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGTATACCAT
TTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCTGGACCTGCTTTGAATTCTCC
ATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGGCAAAGGTCACAAAAGAA
GATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAAAGGGAAA
AGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATAGAACCAGTAGAGACTCC
AGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTCGCCTCACAGGTGCCAACAGT
GACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACATTTGCCATGAAGTACTCA
CAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAATCATCCT
GTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACAGTCCTTCAAAGAGACTG
AGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATGGAAGTGAATCACCTGCAAAA
AGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCCACTGAGGTTAGTCTCTTGTA
TTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAATCCAGCTGATGAGTTACAGC
CTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTTAATTCATCCCAACTGTCT
TTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCTGGCAAAGCTTTTAGAAATACTGC
AAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTTCAAGTTCAATCCTACCT
GTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGGTAGGAGTGTGTGATTTTTTG
CATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCTTTGTGCACATCTTCCCTCTC
CCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTGTATAAGTGGAGGCACTTTAGGGC
TGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTATTAAATACAAAACTTCC
AGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCCACCTTTTGGGAATGTTTTAAATT
CTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATTAATATGAAAACTTATGACCT
CTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTTAAAAAAA
TTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAACAGCTGAATTATCTATACATA
TCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATTCAATTGTAAATTGAATCAGTATA
AACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTCTGCAAAAATATTTATAA

>40334_40334_5_IST1-RBL2_IST1_chr16_71956583_ENST00000538850_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=851AA_BP=105
MHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
PSANTPFSYPLPKGPSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFE
IYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFD
VPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTE
VRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTAN
NGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSN
RPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRT
QPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQF
YNNIYIKQIKTFAMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETP

--------------------------------------------------------------
>40334_40334_6_IST1-RBL2_IST1_chr16_71956583_ENST00000541571_RBL2_chr16_53493362_ENST00000262133_length(transcript)=5050nt_BP=1460nt
TTTTTTCTTTTTTTTGTATTTTTTTTAGTAGAGACGAGATTTCACAATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCA
CCTGCCTCAGTCTCCCCAAGTGCTGGGATTACAGGCATGTGCCACCGCGCCTGGCATGGAACCTGGTTTTATCTTGAAATGTTGCAAACG
TTTATAAAGATACAGTATTTCTAAATTCACATCAACATCTTATGATAAGGGCTAGCTCCTACTTGTCATATGACTGCCCCGGTACAAGCA
TTAGATGCAGCCTCCACAGCAGGGAGCAGATGACTTCCTTCTGGAGGCCCCTTTTTCTTTTTTCCCTTTTTTTTTTTGAGACGTTTCGCT
CTTGTTGCCCAGGCTGGAGGGCAATCGCCGGATCTCGGCTCACTGTAACTCGAGAATCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAG
CTGGGATTACAGGCTTGCGCCACCATGCGTAATTTCCTCTTTAGTAGAGACGGGGTTCCTCTGTGTTGGCCAGGCTGGTCTCGAATTACC
GACTTCAGCGATGCGGTTTCACTATGGTGTCCAGGCTGGTCTGCAACTCCCGGGCTCAAGCGATCCTCCCGCCCCGCCTCTCAAAGTGCT
GGGAAGGTCCCTTCCAGGCTTAAGCAGCGATAATGGTTTTCAAGTTAAAAACAAAGGAGGAACAGCACAGCATGCTGGGCTCTGGATTTA
AAGCTGAGCGCTTAAGAGTGAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAACTGGCCCAGAAAGCAA
GGAAGGAGATTGCTGACTATCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGGAAGACTACCTCGTGG
AGGCCATGGAGATCCTGGAGCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAACTAGATTCTGGTCTGG
CTGAATCTGTGTCTACATTGATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCA
AGTATAGCAAGGAATATGGCAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCC
CACCCAAAATCCTGGTGGAGAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAG
CTCCTCCTGGGGTAGAGACAGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCT
TCACAGCACCAGTTGGTGGACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCAT
ATCCACTGCCAAAGGGACCATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGA
CTCCAGTTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGA
TTCTCAGGACATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAG
ACGAGGATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTA
TTGAGCAGGAACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCC
TTGAGGTCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGG
TGATAGAAGTATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATT
TGGCATGGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGA
ACCTGGAAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTG
GAAGGAGCATAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATG
ATAGCCCCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTG
TTTCTGTCACACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTG
TGCAAGGTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCA
TCCAGCCCCTCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCA
TTCAACAGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTAT
CGCTTTTCTTTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAA
AAATCTGGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTT
ATGTGATGGCAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGT
ATAGAAGTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAA
ACAAAGATAGAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACAC
CTACTCGCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGA
TTAAGACATTTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCC
GAATACAGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACT
TCAGCAACAGTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGG
AAGATGGAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTG
GTTCCCACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTT
CCTTAATCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAG
AACATTTTAATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGAC
TCTGGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGA
ACTGTGTTTCAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAAC
ACCTGGTAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCG
TTCCCTTTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAAC
CTGTATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATG
TGAACTTTATTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATA
GCCACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAG
GGGATTAATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTT
TGGGTGTTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTA
TTTAACAGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAA
ATTCAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGA
ATAGTGTTCTGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTTTCAATAAAGCATT

>40334_40334_6_IST1-RBL2_IST1_chr16_71956583_ENST00000541571_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=1012AA_BP=266
MVFKLKTKEEQHSMLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCD
LLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI
EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKAL
RISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEI
ASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDG
LCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLY
DRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGI
TFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLA
AVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRK
RRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQA
NMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRI

--------------------------------------------------------------
>40334_40334_7_IST1-RBL2_IST1_chr16_71956583_ENST00000544564_RBL2_chr16_53493362_ENST00000262133_length(transcript)=4671nt_BP=1081nt
TAGAGACAGATTTTCGCAATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCCCCTGCCTTACCCTCCCAAAATGCTGGGA
TTACAGAGATACTGTTTCGAATAATTGGCTTGTTGGGGTACAATTCACAGTTGATATATTACAGGATCTAAATAGACAGCGATGCGGTTT
CACTATGGTGTCCAGGCTGGTCTGCAACTCCCGGGCTCAAGCGATCCTCCCGCCCCGCCTCTCAAAGTGCTGGGAAGGTCCCTTCCAGGC
TTAAGCAGCGATAATGGTTTTCAAGTTAAAAACAAAGGAGGAACAGCACAGCATGCTGGGCTCTGGATTTAAAGCTGAGCGCTTAAGAGT
GAATTTGAGATTAGTCATAAATCGCCTTAAACTATTGGAGAAAAAGAAAACGGAACTGGCCCAGAAAGCAAGGAAGGAGATTGCTGACTA
TCTGGCTGCTGGGAAAGATGAACGAGCTCGGATCCGTGTGGAGCACATTATCCGGGAAGACTACCTCGTGGAGGCCATGGAGATCCTGGA
GCTGTACTGTGACCTGCTGCTGGCTCGGTTTGGCCTTATCCAGTCTATGAAGGAACTAGATTCTGGTCTGGCTGAATCTGTGTCTACATT
GATCTGGGCTGCTCCTCGACTCCAGTCAGAAGTGGCTGAGTTGAAAATAGTTGCTGATCAGCTCTGTGCCAAGTATAGCAAGGAATATGG
CAAGCTATGTAGGACCAACCAGATTGGAACTGTGAATGACAGGCTAATGCACAAGCTGAGTGTGGAAGCCCCACCCAAAATCCTGGTGGA
GAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTCCTCCTGGGGTAGAGAC
AGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCACAGCACCAGTTGGTGG
ACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATCCACTGCCAAAGGGACC
ATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTCCAGTTTCTACAGCTAC
GCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGACATGTTCCAG
AGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACGAGGATTTCAGTAATTG
TGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGGAACAAAAAAG
ACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTGAGGTCGTCACTTTTTC
TTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAGTATTCATTAG
AGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGGCATGGAAACCAGAGTC
TCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACCTGGAAAGGGCAGATGA
AATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCATAACATCTCC
AACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATAGCCCCTCTGATGGAGG
GACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCACACCAGTTCC
TGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGCAAGGTATTGCCAATGA
AAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCCTCAGTGCTCA
GGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTCAACAGATTTCCCCAGG
TGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCTTTAGAAAGGT
ATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAATCTGGACCTGCTTTGA
ATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGGCAAAGGTCAC
AAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATAGAAGTGTTTTGATAAA
AGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATAGAACCAGTAG
AGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTACTCGCCTCACAGGTGC
CAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACATTTGCCATGAA
GTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAATACAGTTGTCTCAAAA
TCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACAGTCCTTCAAA
GAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAGATGGAAGTGAATCACC
TGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCCACTGAGGTTAGTC
TCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAATCCAGCTGATGAG
TTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTTAATTCATCCCA
ACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCTGGCAAAGCTTTTAGAA
ATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTTCAAGTTCAAT
CCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGGTAGGAGTGTGTGA
TTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCTTTGTGCACATCTT
CCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTGTATAAGTGGAGGCACT
TTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTATTAAATACAA
AACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCCACCTTTTGGGAATGTT
TTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATTAATATGAAAACTT
ATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTT
AAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAACAGCTGAATTATCT
ATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATTCAATTGTAAATTGAAT
CAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTCTGCAAAAATA

>40334_40334_7_IST1-RBL2_IST1_chr16_71956583_ENST00000544564_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=1012AA_BP=266
MVFKLKTKEEQHSMLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCD
LLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI
EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPSANTPFSYPLPKGPSKAL
RISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEI
ASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDG
LCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLY
DRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGI
TFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLA
AVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRK
RRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQA
NMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRI

--------------------------------------------------------------
>40334_40334_8_IST1-RBL2_IST1_chr16_71956583_ENST00000606369_RBL2_chr16_53493362_ENST00000262133_length(transcript)=3967nt_BP=377nt
ATTTTGGATGGTGAACCCTGAAGTCGGTGTCTGCTGCGTTCACGGCAGGATTCGGTTAGCTAATGCACAAGCTGAGTGTGGAAGCCCCAC
CCAAAATCCTGGTGGAGAGATACCTGATTGAAATTGCAAAGAATTACAACGTACCCTATGAACCTGACTCTGTGGTCATGGCAGAAGCTC
CTCCTGGGGTAGAGACAGATCTTATTGATGTTGGATTCACAGATGATGTGAAGAAAGGAGGCCCTGGAAGAGGAGGGAGTGGTGGCTTCA
CAGCACCAGTTGGTGGACCTGATGGAACGGTGCCAATGCCCATGCCCATGCCCATGCCTATGCCATCTGCAAATACGCCTTTCTCATATC
CACTGCCAAAGGGACCATCCAAAGCACTTAGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACTC
CAGTTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGGAATGCACCAAGTGAGAAACTGGAACAGATTC
TCAGGACATGTTCCAGAGATCCAACCCAGGCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGACG
AGGATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATGCTTTACTATAAAGTATTAGAATCTGTTATTG
AGCAGGAACAAAAAAGACTAGGAGACATGGATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTTG
AGGTCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTTGATGTGCCTCTTTATCATTTTTATAAGGTGA
TAGAAGTATTCATTAGAGCAGAAGATGGCCTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTGG
CATGGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCTACATGTGAAGAGGTCATGCCACCTCAGAACC
TGGAAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACTCCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAA
GGAGCATAACATCTCCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTATTTGTTGAGAATGATA
GCCCCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCCCTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTT
CTGTCACACCAGTTCCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACGGTAACCATTCCTGTGC
AAGGTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTCCAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCC
AGCCCCTCAGTGCTCAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCTGGTCAAGTGGCCATTC
AACAGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCTGTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGC
TTTTCTTTAGAAAGGTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGATGAATTGAGGAAAAAAA
TCTGGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTTATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATG
TGATGGCAAAGGTCACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCCCGGAGCCAGGTGTATA
GAAGTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGCAGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACA
AAGATAGAACCAGTAGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGTGCTCCTCCCACACCTA
CTCGCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGGGGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTA
AGACATTTGCCATGAAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACAGGCTCCCCTCGCCGAA
TACAGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAAAATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCA
GCAACAGTCCTTCAAAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGAGGAATTCTTTTGGAAG
ATGGAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCATTCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTT
CCCACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCT
TAATCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAAC
ATTTTAATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAACTTGGATTTTTGACTCT
GGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACT
GTGTTTCAAGTTCAATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACC
TGGTAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTC
CCTTTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAATGTCTGAGTGAACCTG
TATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGA
ACTTTATTAAATACAAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTATAGCC
ACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGG
ATTAATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGG
GTGTTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTT
AACAGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCTTATTAGGGAGAAAATT
CAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATA
GTGTTCTGCAAAAATATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTTTCAATAAAGCATTTAT

>40334_40334_8_IST1-RBL2_IST1_chr16_71956583_ENST00000606369_RBL2_chr16_53493362_ENST00000262133_length(amino acids)=851AA_BP=105
MHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM
PSANTPFSYPLPKGPSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFE
IYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFD
VPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTE
VRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTAN
NGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSN
RPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRT
QPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQF
YNNIYIKQIKTFAMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IST1-RBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+7101_168253.0361.0CHMP1A and CHMP1B
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+791_168253.0336.0CHMP1A and CHMP1B
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+7101_168253.0367.0CHMP1A and CHMP1B
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+7101_168266.0380.0CHMP1A and CHMP1B
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+8111_168253.0367.0CHMP1A and CHMP1B
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+9121_168253.0367.0CHMP1A and CHMP1B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+71064_279253.0361.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+7964_279253.0336.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+71064_279253.0367.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+71064_279266.0380.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+81164_279253.0367.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+91264_279253.0367.0VPS37B
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+710348_364253.0361.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+79348_364253.0336.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+710348_364253.0367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+710348_364266.0380.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+811348_364253.0367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+912348_364253.0367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
HgeneIST1chr16:71956583chr16:53493362ENST00000329908+710190_364253.0361.0VTA1
HgeneIST1chr16:71956583chr16:53493362ENST00000378798+79190_364253.0336.0VTA1
HgeneIST1chr16:71956583chr16:53493362ENST00000378799+710190_364253.0367.0VTA1
HgeneIST1chr16:71956583chr16:53493362ENST00000535424+710190_364266.0380.0VTA1
HgeneIST1chr16:71956583chr16:53493362ENST00000541571+811190_364253.0367.0VTA1
HgeneIST1chr16:71956583chr16:53493362ENST00000544564+912190_364253.0367.0VTA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IST1-RBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IST1-RBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource