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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITCH-CBFA2T2 (FusionGDB2 ID:40346)

Fusion Gene Summary for ITCH-CBFA2T2

check button Fusion gene summary
Fusion gene informationFusion gene name: ITCH-CBFA2T2
Fusion gene ID: 40346
HgeneTgene
Gene symbol

ITCH

CBFA2T2

Gene ID

83737

9139

Gene nameitchy E3 ubiquitin protein ligaseCBFA2/RUNX1 partner transcriptional co-repressor 2
SynonymsADMFD|AIF4|AIP4|NAPP1EHT|MTGR1|ZMYND3|p85
Cytomap

20q11.22

20q11.21-q11.22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Itchy homologHECT-type E3 ubiquitin transferase Itchy homologNFE2-associated polypeptide 1atrophin-1 interacting protein 4itchy E3 ubiquitin protein ligase homologprotein CBFA2T2CBFA2/RUNX1 translocation partner 2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-rela
Modification date2020032920200313
UniProtAcc.

O43439

Ensembl transtripts involved in fusion geneENST00000262650, ENST00000374864, 
ENST00000535650, ENST00000483727, 
ENST00000344201, ENST00000346541, 
ENST00000359606, ENST00000397798, 
ENST00000397800, ENST00000491618, 
ENST00000492345, ENST00000543126, 
ENST00000342704, ENST00000375279, 
Fusion gene scores* DoF score27 X 16 X 18=777617 X 18 X 9=2754
# samples 4425
** MAII scorelog2(44/7776*10)=-4.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2754*10)=-3.46152855947288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITCH [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITCH(32981687)-CBFA2T2(32232153), # samples:2
Anticipated loss of major functional domain due to fusion event.ITCH-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ITCH-CBFA2T2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITCH

GO:0006511

ubiquitin-dependent protein catabolic process

15678106

HgeneITCH

GO:0016567

protein ubiquitination

17592138|25631046

HgeneITCH

GO:0035519

protein K29-linked ubiquitination

17028573|18628966

HgeneITCH

GO:0070534

protein K63-linked ubiquitination

18718448|19592251

HgeneITCH

GO:0070936

protein K48-linked ubiquitination

19881509

TgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

TgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check buttonFusion gene breakpoints across ITCH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBFA2T2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-20-1684-01AITCHchr20

32981687

+CBFA2T2chr20

32232153

+
ChimerDB4OVTCGA-20-1684ITCHchr20

32981687

+CBFA2T2chr20

32232152

+


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Fusion Gene ORF analysis for ITCH-CBFA2T2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262650ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000262650ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000262650ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5CDS-intronENST00000374864ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5CDS-intronENST00000374864ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-3CDSENST00000535650ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-3CDSENST00000535650ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-3CDSENST00000535650ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-3CDSENST00000535650ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
5UTR-intronENST00000535650ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
5UTR-intronENST00000535650ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
Frame-shiftENST00000262650ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
Frame-shiftENST00000262650ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
Frame-shiftENST00000374864ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
Frame-shiftENST00000374864ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
In-frameENST00000262650ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
In-frameENST00000262650ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
In-frameENST00000374864ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
In-frameENST00000374864ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-3CDSENST00000483727ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-3CDSENST00000483727ENST00000342704ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-3CDSENST00000483727ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-3CDSENST00000483727ENST00000375279ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000344201ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000346541ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000359606ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000397798ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000397800ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000491618ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000492345ITCHchr20

32981687

+CBFA2T2chr20

32232152

+
intron-intronENST00000483727ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232153

+
intron-intronENST00000483727ENST00000543126ITCHchr20

32981687

+CBFA2T2chr20

32232152

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374864ITCHchr2032981687+ENST00000375279CBFA2T2chr2032232153+59732831097597166
ENST00000262650ITCHchr2032981687+ENST00000375279CBFA2T2chr2032232153+58962061020520166
ENST00000374864ITCHchr2032981687+ENST00000375279CBFA2T2chr2032232152+59732831097597166
ENST00000262650ITCHchr2032981687+ENST00000375279CBFA2T2chr2032232152+58962061020520166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374864ENST00000375279ITCHchr2032981687+CBFA2T2chr2032232153+0.450985280.54901475
ENST00000262650ENST00000375279ITCHchr2032981687+CBFA2T2chr2032232153+0.441095140.5589049
ENST00000374864ENST00000375279ITCHchr2032981687+CBFA2T2chr2032232152+0.450985280.54901475
ENST00000262650ENST00000375279ITCHchr2032981687+CBFA2T2chr2032232152+0.441095140.5589049

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Fusion Genomic Features for ITCH-CBFA2T2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITCHchr2032981687+CBFA2T2chr2032232152+6.58E-091
ITCHchr2032981687+CBFA2T2chr2032232152+6.58E-091
ITCHchr2032981687+CBFA2T2chr2032232152+6.58E-091
ITCHchr2032981687+CBFA2T2chr2032232152+6.58E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ITCH-CBFA2T2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:32981687/chr20:32232153)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBFA2T2

O43439

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003442010633_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003977980733_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003442010633_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003977980733_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106113_2080264.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807113_2080264.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106113_2080264.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807113_2080264.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911517_553496596.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012517_553505605.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911517_553515615.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012517_553505605.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911517_553476576.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113517_553476576.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911517_553496596.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012517_553505605.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911517_553515615.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012517_553505605.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911517_553476576.0Zinc fingerMYND-type
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113517_553476576.0Zinc fingerMYND-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326252_26723904.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325252_26723863.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324252_2670753.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326252_26723904.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325252_26723863.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324252_2670753.0Compositional biasNote=Arg/Pro-rich (PRR domain)
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+3261_11523904.0DomainC2
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326326_35923904.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326358_39123904.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326438_47123904.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326478_51123904.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326569_90323904.0DomainHECT
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+3251_11523863.0DomainC2
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325326_35923863.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325358_39123863.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325438_47123863.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325478_51123863.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325569_90323863.0DomainHECT
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+3241_1150753.0DomainC2
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324326_3590753.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324358_3910753.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324438_4710753.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324478_5110753.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324569_9030753.0DomainHECT
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+3261_11523904.0DomainC2
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326326_35923904.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326358_39123904.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326438_47123904.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326478_51123904.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326569_90323904.0DomainHECT
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+3251_11523863.0DomainC2
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325326_35923863.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325358_39123863.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325438_47123863.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325478_51123863.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325569_90323863.0DomainHECT
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+3241_1150753.0DomainC2
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324326_3590753.0DomainWW 1
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324358_3910753.0DomainWW 2
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324438_4710753.0DomainWW 3
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324478_5110753.0DomainWW 4
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324569_9030753.0DomainHECT
HgeneITCHchr20:32981687chr20:32232152ENST00000262650+326574_58323904.0RegionMAP kinase docking site
HgeneITCHchr20:32981687chr20:32232152ENST00000374864+325574_58323863.0RegionMAP kinase docking site
HgeneITCHchr20:32981687chr20:32232152ENST00000535650+324574_5830753.0RegionMAP kinase docking site
HgeneITCHchr20:32981687chr20:32232153ENST00000262650+326574_58323904.0RegionMAP kinase docking site
HgeneITCHchr20:32981687chr20:32232153ENST00000374864+325574_58323863.0RegionMAP kinase docking site
HgeneITCHchr20:32981687chr20:32232153ENST00000535650+324574_5830753.0RegionMAP kinase docking site
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911451_491496596.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012451_491505605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911451_491515615.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012451_491505605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911451_491476576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113451_491476576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911451_491496596.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012451_491505605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911451_491515615.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012451_491505605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911451_491476576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113451_491476576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034270491133_97496596.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000346541101233_97505605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000035960691133_97515615.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000375279101233_97505605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039780091133_97476576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000492345111333_97476576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034270491133_97496596.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000346541101233_97505605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000035960691133_97515615.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000375279101233_97505605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039780091133_97476576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000492345111333_97476576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911113_208496596.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012113_208505605.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911113_208515615.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012113_208505605.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911113_208476576.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113113_208476576.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911113_208496596.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012113_208505605.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911113_208515615.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012113_208505605.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911113_208476576.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113113_208476576.0DomainTAFH
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911331_377496596.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911435_484496596.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012331_377505605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012435_484505605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911331_377515615.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911435_484515615.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012331_377505605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012435_484505605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911331_377476576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911435_484476576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113331_377476576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113435_484476576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911331_377496596.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911435_484496596.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012331_377505605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012435_484505605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911331_377515615.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911435_484515615.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012331_377505605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012435_484505605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911331_377476576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911435_484476576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113331_377476576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113435_484476576.0RegionNervy homology region 3 (NHR3)


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Fusion Gene Sequence for ITCH-CBFA2T2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40346_40346_1_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000262650_CBFA2T2_chr20_32232152_ENST00000375279_length(transcript)=5896nt_BP=206nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAA
GTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCAC
CATGAAATCACAGCTTCAGATCACTGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACT
GTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCC
GGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCA
CATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAG
CACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGA
AGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGC
CAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACC
AGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAG
GAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCT
CACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAA
GAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGAT
TTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGAT
TGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATC
ATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACAT
CTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGT
AGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCAT
TATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAG
AAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATC
CCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAG
TCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTC
AGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGG
CCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCT
GTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCA
GTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAA
TAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGT
CCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCA
ACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTA
CTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCA
ACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAG
TCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAG
AATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTT
AAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAG
GTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTT
TGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGG
TTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAG
ACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACA
GGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTT
GGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCT
GGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGC
TGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCA
CGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATT
GGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGT
GGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGG
TACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTC
TAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGG
GACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGC
CTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGC
ACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGC
GTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGC
TGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACA
TCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAG
GGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCT
CTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAG
GCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTG
TTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAG
CTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTG
TGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGT
GAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGA
CCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAG
CCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCC
CCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGC
CTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTA
CTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGT

>40346_40346_1_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000262650_CBFA2T2_chr20_32232152_ENST00000375279_length(amino acids)=166AA_BP=
MPPVAYPSPREANQCHLLRMEMGPKELFRGEAGRSLTEGPPPQPAACRLPPPAWLSTLDSLLTQGDGEGSWWSTLKRGRLSQLQWREEQT

--------------------------------------------------------------
>40346_40346_2_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000262650_CBFA2T2_chr20_32232153_ENST00000375279_length(transcript)=5896nt_BP=206nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAA
GTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCAC
CATGAAATCACAGCTTCAGATCACTGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACT
GTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCC
GGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCA
CATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAG
CACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGA
AGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGC
CAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACC
AGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAG
GAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCT
CACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAA
GAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGAT
TTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGAT
TGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATC
ATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACAT
CTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGT
AGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCAT
TATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAG
AAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATC
CCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAG
TCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTC
AGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGG
CCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCT
GTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCA
GTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAA
TAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGT
CCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCA
ACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTA
CTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCA
ACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAG
TCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAG
AATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTT
AAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAG
GTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTT
TGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGG
TTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAG
ACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACA
GGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTT
GGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCT
GGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGC
TGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCA
CGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATT
GGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGT
GGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGG
TACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTC
TAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGG
GACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGC
CTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGC
ACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGC
GTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGC
TGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACA
TCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAG
GGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCT
CTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAG
GCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTG
TTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAG
CTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTG
TGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGT
GAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGA
CCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAG
CCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCC
CCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGC
CTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTA
CTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGT

>40346_40346_2_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000262650_CBFA2T2_chr20_32232153_ENST00000375279_length(amino acids)=166AA_BP=
MPPVAYPSPREANQCHLLRMEMGPKELFRGEAGRSLTEGPPPQPAACRLPPPAWLSTLDSLLTQGDGEGSWWSTLKRGRLSQLQWREEQT

--------------------------------------------------------------
>40346_40346_3_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000374864_CBFA2T2_chr20_32232152_ENST00000375279_length(transcript)=5973nt_BP=283nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGA
GGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTG
TGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAG
CTTCAGATCACTGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTG
CCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCC
TGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTC
AACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGC
TTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCT
GAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGC
CTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCC
ATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGT
CAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGG
GTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTG
CAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGC
TGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAG
AATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAAT
GCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTG
GGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCC
ACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATG
TTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGA
AATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGT
TAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTG
CCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTA
GCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTC
GAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTT
TGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTT
TAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAG
TACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGC
AGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACAT
GGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGA
GGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACT
CTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAA
TCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTT
TGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCT
TGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCAT
TACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAG
ACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCT
CCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCC
TTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACT
GTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCC
AAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGT
GGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACC
TGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGC
CCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGG
CAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAAT
TCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATC
AGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCA
GTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGAC
CAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCT
GACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGG
GGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCT
AGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCT
CTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCA
GACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCA
TTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAA
ACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAA
CTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACT
GGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAG
CCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACG
TTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAG
GTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCG
AGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACC
TTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCT
TTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGT
TTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAAT
TTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAA

>40346_40346_3_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000374864_CBFA2T2_chr20_32232152_ENST00000375279_length(amino acids)=166AA_BP=
MPPVAYPSPREANQCHLLRMEMGPKELFRGEAGRSLTEGPPPQPAACRLPPPAWLSTLDSLLTQGDGEGSWWSTLKRGRLSQLQWREEQT

--------------------------------------------------------------
>40346_40346_4_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000374864_CBFA2T2_chr20_32232153_ENST00000375279_length(transcript)=5973nt_BP=283nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGA
GGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTG
TGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAG
CTTCAGATCACTGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTG
CCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCC
TGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTC
AACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGC
TTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCT
GAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGC
CTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCC
ATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGT
CAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGG
GTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTG
CAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGC
TGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAG
AATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAAT
GCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTG
GGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCC
ACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATG
TTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGA
AATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGT
TAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTG
CCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTA
GCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTC
GAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTT
TGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTT
TAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAG
TACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGC
AGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACAT
GGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGA
GGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACT
CTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAA
TCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTT
TGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCT
TGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCAT
TACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAG
ACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCT
CCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCC
TTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACT
GTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCC
AAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGT
GGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACC
TGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGC
CCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGG
CAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAAT
TCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATC
AGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCA
GTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGAC
CAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCT
GACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGG
GGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCT
AGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCT
CTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCA
GACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCA
TTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAA
ACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAA
CTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACT
GGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAG
CCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACG
TTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAG
GTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCG
AGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACC
TTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCT
TTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGT
TTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAAT
TTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAA

>40346_40346_4_ITCH-CBFA2T2_ITCH_chr20_32981687_ENST00000374864_CBFA2T2_chr20_32232153_ENST00000375279_length(amino acids)=166AA_BP=
MPPVAYPSPREANQCHLLRMEMGPKELFRGEAGRSLTEGPPPQPAACRLPPPAWLSTLDSLLTQGDGEGSWWSTLKRGRLSQLQWREEQT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ITCH-CBFA2T2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000034420106107_2150264.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST0000039779807107_2150264.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000034420106107_2150264.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST0000039779807107_2150264.0PRDM14


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000342704911107_215496.0596.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003465411012107_215505.0605.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000359606911107_215515.0615.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000003752791012107_215505.0605.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST00000397800911107_215476.0576.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232152ENST000004923451113107_215476.0576.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000342704911107_215496.0596.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003465411012107_215505.0605.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000359606911107_215515.0615.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000003752791012107_215505.0605.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST00000397800911107_215476.0576.0PRDM14
TgeneCBFA2T2chr20:32981687chr20:32232153ENST000004923451113107_215476.0576.0PRDM14


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITCH-CBFA2T2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITCH-CBFA2T2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource