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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ITCH-THAP4 (FusionGDB2 ID:40369)

Fusion Gene Summary for ITCH-THAP4

Fusion gene summary

Fusion gene information	Fusion gene name: ITCH-THAP4
	Fusion gene ID: 40369
		Hgene	Tgene
	Gene symbol	ITCH	THAP4
	Gene ID	83737	51078
	Gene name	itchy E3 ubiquitin protein ligase	THAP domain containing 4
	Synonyms	ADMFD\|AIF4\|AIP4\|NAPP1	CGI-36\|Nb(III)\|PP238
	Cytomap	20q11.22	2q37.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Itchy homologHECT-type E3 ubiquitin transferase Itchy homologNFE2-associated polypeptide 1atrophin-1 interacting protein 4itchy E3 ubiquitin protein ligase homolog	THAP domain-containing protein 4epididymis secretory sperm binding proteinnitrobindin
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262650, ENST00000374864, ENST00000535650, ENST00000483727,	ENST00000497486, ENST00000402136, ENST00000402545, ENST00000407315,
Fusion gene scores	* DoF score	27 X 16 X 18=7776	10 X 4 X 8=320
	# samples	44	11
	** MAII score	log2(44/7776*10)=-4.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ITCH [Title/Abstract] AND THAP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ITCH(32981687)-THAP4(242545888), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITCH	GO:0006511	ubiquitin-dependent protein catabolic process	15678106
Hgene	ITCH	GO:0016567	protein ubiquitination	17592138\|25631046
Hgene	ITCH	GO:0035519	protein K29-linked ubiquitination	17028573\|18628966
Hgene	ITCH	GO:0070534	protein K63-linked ubiquitination	18718448\|19592251
Hgene	ITCH	GO:0070936	protein K48-linked ubiquitination	19881509

Fusion gene breakpoints across ITCH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across THAP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-7901	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-

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Fusion Gene ORF analysis for ITCH-THAP4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262650	ENST00000497486	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
5CDS-intron	ENST00000374864	ENST00000497486	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
5UTR-3CDS	ENST00000535650	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
5UTR-3CDS	ENST00000535650	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
5UTR-3CDS	ENST00000535650	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
5UTR-intron	ENST00000535650	ENST00000497486	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000262650	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000262650	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000262650	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000374864	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000374864	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
In-frame	ENST00000374864	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
intron-3CDS	ENST00000483727	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
intron-3CDS	ENST00000483727	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
intron-3CDS	ENST00000483727	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-
intron-intron	ENST00000483727	ENST00000497486	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374864	ITCH	chr20	32981687	+	ENST00000402136	THAP4	chr2	242545888	-	978	283	213	776	187
ENST00000374864	ITCH	chr20	32981687	+	ENST00000407315	THAP4	chr2	242545888	-	978	283	213	776	187
ENST00000374864	ITCH	chr20	32981687	+	ENST00000402545	THAP4	chr2	242545888	-	1037	283	213	857	214
ENST00000262650	ITCH	chr20	32981687	+	ENST00000402136	THAP4	chr2	242545888	-	901	206	136	699	187
ENST00000262650	ITCH	chr20	32981687	+	ENST00000407315	THAP4	chr2	242545888	-	901	206	136	699	187
ENST00000262650	ITCH	chr20	32981687	+	ENST00000402545	THAP4	chr2	242545888	-	960	206	136	780	214

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374864	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.04446691	0.9555331
ENST00000374864	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.04446691	0.9555331
ENST00000374864	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.16152579	0.83847415
ENST00000262650	ENST00000402136	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.04021265	0.95978737
ENST00000262650	ENST00000407315	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.04021265	0.95978737
ENST00000262650	ENST00000402545	ITCH	chr20	32981687	+	THAP4	chr2	242545888	-	0.1511777	0.8488223

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Fusion Genomic Features for ITCH-THAP4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITCH-THAP4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:32981687/chr2:242545888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000402136

235_238

166.0

Motif

HCFC1-binding motif (HBM)

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000402136

415_577

166.0

Region

Nitrobindin

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000407315

415_577

413

578.0

Region

Nitrobindin

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000402136

1_85

166.0

Zinc finger

THAP-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

252_267

904.0

Compositional bias

Note=Arg/Pro-rich (PRR domain)

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

252_267

863.0

Compositional bias

Note=Arg/Pro-rich (PRR domain)

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

252_267

753.0

Compositional bias

Note=Arg/Pro-rich (PRR domain)

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

1_115

904.0

Domain

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

326_359

904.0

Domain

WW 1

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

358_391

904.0

Domain

WW 2

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

438_471

904.0

Domain

WW 3

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

478_511

904.0

Domain

WW 4

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

569_903

904.0

Domain

HECT

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

1_115

863.0

Domain

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

326_359

863.0

Domain

WW 1

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

358_391

863.0

Domain

WW 2

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

438_471

863.0

Domain

WW 3

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

478_511

863.0

Domain

WW 4

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

569_903

863.0

Domain

HECT

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

1_115

753.0

Domain

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

326_359

753.0

Domain

WW 1

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

358_391

753.0

Domain

WW 2

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

438_471

753.0

Domain

WW 3

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

478_511

753.0

Domain

WW 4

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

569_903

753.0

Domain

HECT

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000262650

574_583

904.0

Region

MAP kinase docking site

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000374864

574_583

863.0

Region

MAP kinase docking site

Hgene

ITCH

chr20:32981687

chr2:242545888

ENST00000535650

574_583

753.0

Region

MAP kinase docking site

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000407315

235_238

413

578.0

Motif

HCFC1-binding motif (HBM)

Tgene

THAP4

chr20:32981687

chr2:242545888

ENST00000407315

1_85

413

578.0

Zinc finger

THAP-type

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Fusion Gene Sequence for ITCH-THAP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40369_40369_1_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000402136_length(transcript)=901nt_BP=206nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAA
GTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCAC
CATGAAATCACAGCTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGA
CCCACCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAA
CTTCTCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGT
GGCCTTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCAT
CGCCAGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGT
CTCCATGGCAACCACGACACAGCCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCC
TCGGGAGGGCCTGGCTACTGTGCCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCA
GGCTCAAGAGTGTTGTCCAGATGTTTCTGTACTGGCATAGAAAAACCAAATAAAAGGCCTTTATTTTTATGGCTGAGGATTTTGAATATT

>40369_40369_1_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000402136_length(amino acids)=187AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHV

--------------------------------------------------------------
>40369_40369_2_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000402545_length(transcript)=960nt_BP=206nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAA
GTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCAC
CATGAAATCACAGCTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGA
CCCACCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAA
CTTCTCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGT
GGCCTTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCAT
CGCCAGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGGTGAGCCCAGCCCTGCTCCCAGCACGCTCCTGTCTTCTGTTTGCAGCGGT
CTGTGGAGTCAGCCTCTTCCTCTTCCGTGAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGC
AACCACGACACAGCCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGG
CCTGGCTACTGTGCCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGA

>40369_40369_2_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000402545_length(amino acids)=214AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQVSPALLPARSCLLFAAVCGVSLFLFREITRKF

--------------------------------------------------------------
>40369_40369_3_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000407315_length(transcript)=901nt_BP=206nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAA
GTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCAC
CATGAAATCACAGCTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGA
CCCACCTGGAGCCGGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAA
CTTCTCGTTCAACTCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGT
GGCCTTTGTCAGCGCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCAT
CGCCAGGATCTCCTTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGT
CTCCATGGCAACCACGACACAGCCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCC
TCGGGAGGGCCTGGCTACTGTGCCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCA
GGCTCAAGAGTGTTGTCCAGATGTTTCTGTACTGGCATAGAAAAACCAAATAAAAGGCCTTTATTTTTATGGCTGAGGATTTTGAATATT

>40369_40369_3_ITCH-THAP4_ITCH_chr20_32981687_ENST00000262650_THAP4_chr2_242545888_ENST00000407315_length(amino acids)=187AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHV

--------------------------------------------------------------
>40369_40369_4_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000402136_length(transcript)=978nt_BP=283nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGA
GGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTG
TGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAG
CTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCC
GGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAAC
TCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGC
GCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCC
TTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACC
ACGACACAGCCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTG
GCTACTGTGCCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGT

>40369_40369_4_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000402136_length(amino acids)=187AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHV

--------------------------------------------------------------
>40369_40369_5_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000402545_length(transcript)=1037nt_BP=283nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGA
GGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTG
TGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAG
CTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCC
GGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAAC
TCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGC
GCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCC
TTCGCCAAGGAGCCCCACGTAGAGCAGGTGAGCCCAGCCCTGCTCCCAGCACGCTCCTGTCTTCTGTTTGCAGCGGTCTGTGGAGTCAGC
CTCTTCCTCTTCCGTGAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACCACGACACAG
CCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTGGCTACTGTG
CCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGTTGTCCAGAT

>40369_40369_5_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000402545_length(amino acids)=214AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQVSPALLPARSCLLFAAVCGVSLFLFREITRKF

--------------------------------------------------------------
>40369_40369_6_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000407315_length(transcript)=978nt_BP=283nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGA
GGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTG
TGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAG
CTTCAGATCACTGAGCCCCCCAAGATGAACCCAGTGGTGGAGCCACTGTCCTGGATGCTGGGCACCTGGCTGTCGGACCCACCTGGAGCC
GGGACCTACCCCACACTGCAGCCCTTCCAGTACCTGGAGGAGGTTCACATCTCCCACGTGGGCCAGCCCATGCTGAACTTCTCGTTCAAC
TCCTTCCACCCGGACACGCGCAAGCCGATGCACAGAGAGTGTGGCTTCATTCGCCTCAAGCCCGACACCAACAAGGTGGCCTTTGTCAGC
GCCCAGAACACAGGCGTGGTGGAAGTGGAGGAGGGCGAGGTGAACGGGCAGGAGCTGTGCATCGCATCCCACTCCATCGCCAGGATCTCC
TTCGCCAAGGAGCCCCACGTAGAGCAGATCACCCGGAAGTTCAGGCTGAATTCTGAAGGCAAACTTGAGCAGACGGTCTCCATGGCAACC
ACGACACAGCCAATGACTCAGCATCTTCACGTCACCTACAAGAAGGTGACCCCGTAAACCTAGAGCTTCTGGAGCCCTCGGGAGGGCCTG
GCTACTGTGCCTCAACGGTTCGGCTCCTCAACAGACAGTCCCTGCGGCAGAAGTGGGTGTGGCCGTGAGCCTCTGCAGGCTCAAGAGTGT

>40369_40369_6_ITCH-THAP4_ITCH_chr20_32981687_ENST00000374864_THAP4_chr2_242545888_ENST00000407315_length(amino acids)=187AA_BP=23
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMH
RECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ITCH-THAP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ITCH-THAP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ITCH-THAP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source