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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITFG1-ARHGEF7 (FusionGDB2 ID:40371)

Fusion Gene Summary for ITFG1-ARHGEF7

check button Fusion gene summary
Fusion gene informationFusion gene name: ITFG1-ARHGEF7
Fusion gene ID: 40371
HgeneTgene
Gene symbol

ITFG1

ARHGEF7

Gene ID

81533

8874

Gene nameintegrin alpha FG-GAP repeat containing 1Rho guanine nucleotide exchange factor 7
Synonyms2310047C21Rik|CDA08|LNKN-1|TIPBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB
Cytomap

16q12.1

13q34

Type of geneprotein-codingprotein-coding
DescriptionT-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein
Modification date2020031320200327
UniProtAcc

Q8TB96

Q14155

Ensembl transtripts involved in fusion geneENST00000320640, ENST00000544001, 
ENST00000568047, 		ENST00000483189, 
ENST00000218789, ENST00000375723, 
ENST00000375736, ENST00000375737, 
ENST00000426073, ENST00000478679, 
ENST00000544132, ENST00000317133, 
ENST00000370623, ENST00000375739, 
ENST00000375741, 
Fusion gene scores* DoF score9 X 9 X 5=40513 X 13 X 5=845
# samples 913
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/845*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITFG1 [Title/Abstract] AND ARHGEF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITFG1(47399699)-ARHGEF7(111896219), # samples:1
Anticipated loss of major functional domain due to fusion event.ITFG1-ARHGEF7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ITFG1-ARHGEF7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across ITFG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8296-01AITFG1chr16

47399699

-ARHGEF7chr13

111896219

+


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Fusion Gene ORF analysis for ITFG1-ARHGEF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000320640ENST00000483189ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-3UTRENST00000544001ENST00000483189ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000218789ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000375723ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000375736ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000375737ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000426073ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000478679ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000320640ENST00000544132ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000218789ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000375723ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000375736ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000375737ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000426073ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000478679ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
5CDS-intronENST00000544001ENST00000544132ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
Frame-shiftENST00000320640ENST00000317133ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
Frame-shiftENST00000320640ENST00000370623ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
Frame-shiftENST00000320640ENST00000375739ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
Frame-shiftENST00000320640ENST00000375741ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
In-frameENST00000544001ENST00000317133ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
In-frameENST00000544001ENST00000370623ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
In-frameENST00000544001ENST00000375739ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
In-frameENST00000544001ENST00000375741ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-3CDSENST00000568047ENST00000317133ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-3CDSENST00000568047ENST00000370623ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-3CDSENST00000568047ENST00000375739ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-3CDSENST00000568047ENST00000375741ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-3UTRENST00000568047ENST00000483189ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000218789ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000375723ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000375736ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000375737ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000426073ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000478679ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+
intron-intronENST00000568047ENST00000544132ITFG1chr16

47399699

-ARHGEF7chr13

111896219

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544001ITFG1chr1647399699-ENST00000317133ARHGEF7chr13111896219+34487547272343538
ENST00000544001ITFG1chr1647399699-ENST00000375741ARHGEF7chr13111896219+52077547272343538
ENST00000544001ITFG1chr1647399699-ENST00000375739ARHGEF7chr13111896219+52077547272343538
ENST00000544001ITFG1chr1647399699-ENST00000370623ARHGEF7chr13111896219+50257547272406559

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544001ENST00000317133ITFG1chr1647399699-ARHGEF7chr13111896219+0.0164151530.9835849
ENST00000544001ENST00000375741ITFG1chr1647399699-ARHGEF7chr13111896219+0.0070029860.992997
ENST00000544001ENST00000375739ITFG1chr1647399699-ARHGEF7chr13111896219+0.0070029860.992997
ENST00000544001ENST00000370623ITFG1chr1647399699-ARHGEF7chr13111896219+0.0028915940.9971084

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Fusion Genomic Features for ITFG1-ARHGEF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITFG1chr1647399698-ARHGEF7chr13111896218+0.684852360.31514764
ITFG1chr1647399698-ARHGEF7chr13111896218+0.684852360.31514764

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ITFG1-ARHGEF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:47399699/chr13:111896219)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITFG1

Q8TB96

ARHGEF7

Q14155

FUNCTION: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). {ECO:0000250}.FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000317133519271_451253783.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000317133519473_578253783.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000370623319184_243181732.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000370623319271_451181732.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000370623319473_578181732.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375723317184_24396626.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375723317271_45196626.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375723317473_57896626.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375736420184_24396647.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375736420271_45196647.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375736420473_57896647.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375739418271_451224754.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375739418473_578224754.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375741620271_451274804.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375741620473_578274804.0DomainPH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000426073420184_24396647.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000426073420271_45196647.0DomainDH
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000426073420473_57896647.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITFG1chr16:47399699chr13:111896219ENST00000320640-818258_293267613.0RepeatNote=FG-GAP%3B atypical
HgeneITFG1chr16:47399699chr13:111896219ENST00000320640-818567_587267613.0TransmembraneHelical
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000317133519184_243253783.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003171335191_133253783.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003706233191_133181732.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003757233171_13396626.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003757364201_13396647.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375739418184_243224754.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003757394181_133224754.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST00000375741620184_243274804.0DomainSH3
TgeneARHGEF7chr16:47399699chr13:111896219ENST000003757416201_133274804.0DomainCalponin-homology (CH)
TgeneARHGEF7chr16:47399699chr13:111896219ENST000004260734201_13396647.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for ITFG1-ARHGEF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40371_40371_1_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000317133_length(transcript)=3448nt_BP=754nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGAAATGACTTAATCGTCTTT
TTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGTCCCTGGG
GATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTATCTTCTGG
GGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAATGGTGAT
CTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGCATTGACC
ACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGACATTGAAT
GCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCAAAATATG
ATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGT
GCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATG
TTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCT
GATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGG
GGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATA
CCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAA
CCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGA
CATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACT
CTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAAT
CACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCA
GCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCC
ATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCT
GCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAG
CTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCT
GCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGAT
TCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCA
CGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGA
CTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAA
CTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTT
ATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGA
ATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCC
AAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCAC
ACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGAT
CAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAAC
AGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCT
TCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTC
ACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGT
TTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTG
CTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAAC
CAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATT

>40371_40371_1_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000317133_length(amino acids)=538AA_BP=9
MDSQHLQTLVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMP
QMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLS
AQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITK
LEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPH
PSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILK

--------------------------------------------------------------
>40371_40371_2_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000370623_length(transcript)=5025nt_BP=754nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGAAATGACTTAATCGTCTTT
TTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGTCCCTGGG
GATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTATCTTCTGG
GGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAATGGTGAT
CTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGCATTGACC
ACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGACATTGAAT
GCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCAAAATATG
ATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGT
GCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATG
TTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCT
GATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGG
GGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATA
CCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAA
CCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGA
CATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACT
CTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAAT
CACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCA
GCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCC
ATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCT
GCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAG
CTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCT
GCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGAT
TCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAAGTTCACGCAAAGAATCTGCTCCACAAGTTTT
GCTTCCAGAAGAAGAGAAAATTATAGTGGAAGAAACTAAAAGTAATGGTCAGACAGTGATAGAAGAAAAGAGTCTTGTGGATACCGTATA
TGCATTAAAGGATGAAGTTCAAGAATTAAGACAGGACAACAAAAAGATGAAGAAATCTCTAGAGGAAGAACAGAGAGCCCGCAAAGACCT
GGAGAAGCTGGTGAGGAAAGTCCTGAAGAACATGAATGATCCTGCCTGGGATGAGACCAATCTATAAGGGATGTCCTCAGTTCTTTCTGT
TGAAGACCAGTTCTGAGGTGAAGCTGGGCACCCCTGACCCAAGTCGGGGTGCACTCAGGACCACAGGGCAGGGCTGGGTGGGGCGCCACC
TTGCTCTCTGTATATAGAAAAGCTGGAGCTTATTCTGCGAATGGAGACGATCAAACCATGACTGATGAATCCAGACAGGAGGGATTGACT
CTGAGGACCTGAGCTACATCAATCCACTCTGTGAACATCTCAGTTACCTCATTCTGCAATAAGTTCAGTGACTGACTAAAAGTCTTGTTT
TTCCAGACTTTGAATTGAATATATAAATATTATATATACATGTTTCTTGTAAATATCCCATTTTGAATGCATACCTGTGGTGGTTCTGTC
CGGGCTAATCCCCATGCTAGAATGTCCTTTCCAGCTACGTGAATAAGAAGTCCCATGCCCGCATCCACCGGAAGCAGAAGCCTGGTGGAT
GCCTGGTTCGTTCCGCAGCACCAGGGCCTCCACCGTGCTGTGGCAGCACCCCCCATGTCGGTATTTCTAAATAACCTTATTTATACCTGC
AGAGATACACTTCAGTCCCATTCAGAAGTCTTCTCTTAAAGCAGCATTACAGTCCCAGACCTGCGGGTTTCTGAGGGCAACTTGCTGGCT
GACAGACTCAGTCTTGACCTCAAGGAAGGCCCATACGGCACTGCCGCATCCACCTAGAGGTGTTTGCTCTTGTCCGCTGTCTGAGTACTG
TGATTCTCAGATGAGTTTGCTGCGTTTTGGGAGGACACAGACGGTTCTGTATAGGCTAGTTCAGTAACAACAAAATACACTGTTTTGTCT
TCCCTCAAAGAGAGATCTTACTAGAACCTGTAAATAGAATGTATTATTTATTATAAGTCACTGCAGCTGATGAAAACAGATGGAGGCCAT
GCTGCAGGCTGATACTGATGGGTGGAGTTTTGTCATCAGGCCAGCCTCATCCCGAGGTCTCCTCCACCATTGGCCGTAGCCAGCAGGCTT
CAGTGCTCACCGAAAGTAAAATCCCCTCCTTCAGCAAGAATAAAGCAATATACACCTTAGGTTCCACTAAGTAACATAGGCATAAGCAGG
GAACGTTTCCCCCACTGTGTTCCAGTGCAGAGGAGACGAAGCCTGTCCTCACCGCGGCTCGCTGGGCCCAGGCTGGCTCTGGAAAGCCTG
TGCGGTCCTGGGCAGGAAGCCCGGCCCGTGGAGCAGGTTTTCGTTCTGCTTCAGCAATAAATAAGGGTGACCACAGGGACTTTGCTTTTG
GTTTCCTTTCCTGTGAAAAGGTTGGTTTTAAAGTGAGATACACTTTTCCGTAGAACAAGTGTTCTATCTTTAAAAACCCAAATTGCAGCA
CCGTGGATTACTGGTCTCAGAACAACTCATTGCGCATCAGATTTGACTCTCTGATTTTCTGTCTATTGGCCAAATTGCCCTTTAACTGCA
CCTGAATCCTTTGTGTACTGATGCCTTTGAGCTGGGCACCTTGGGAGAGTGTTGTGTTGCTGTTTACGGTTCTTCCTTGCCCTTGCTAAT
TACAGTCTCTGGTGCCCAGCAAGCCCCTTTGGCTTCCTTCCGTGACTGGTCACGTTGTCTGCCTGGGCTCAGCGTGGACCTGCCCCATGC
TGCAGAACCTGGCCTCACCTGGACTTTTCACTAGAATTGCCAGCTTCCTCAACTTAGCAGATCATTCACTCATGCGGGCACAAGCAAAGA
TCAACACTTTCTTTTTTGGTAAGCTTGAGTTTTACAAGTTATTTTTTGGTGATGCGTAAGACATTGCAGTGGGAAACCATTCAACTTGAG
TTTATTGGAGTTTGCTGTTGTAGCAGGTTTTAACTCAGGAACAACTCTTGTCTGATCTCTCCGCCCCTCTGCCGGGAGGCGACATTAACT
GTCCTCTCGGAGCCGGTAGCGTTGCTGTCCGAGTCCCCAGGACGGATCTCCTGCAGACCTGCCTTAATGCTCAGATCGAAGTATTTCACA
AGAATACTTGTGTTTTTAACAGCCCTTCCCCTGGACGGTGCGGCCATGAGGGCCTCATGTTACGGCATTGCCTTTTCTTTCTGTGGATCC
AGTATCTTCCTCGGCTTTTTAGGGAGCAGGAAAAATGCGTCTGAGAGCAACTCTTTTTAAAAACCTGCCCTGTTGTATATAACTGTGTCT
GTTTCACCGTGTGACCTCCCAAGGGGGTGGGAACTTGATATAAACGTTTAAAGGGGCCACGATTTGCCCGAGGGTTACTCCTTTGCTCTC
ACCTTGTATGGATGAGGAGATGAAGCCATTTCTTATCCTGTAGATGTGAAGCACTTTCAGTTTTCAGCGATGTTGGAATGTAGCATCAGA
AGCTCGTTCCTTCACACTCAGTGGCGTCTGTGCTTGTCCACATGCGCTGGGCGTCTGGGACCTTGAATGCCTGCCCTGGTTGTGTGGACT
CCTTAATGCCAATCATTTCTTCACTTCTCTGGGACACCCAGGGCGCCTGTTGACAAGTGTGGAGAAACTCCTAATTTAAATGTCACAGAC

>40371_40371_2_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000370623_length(amino acids)=559AA_BP=9
MDSQHLQTLVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMP
QMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLS
AQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITK
LEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPH
PSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILK
VIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEK

--------------------------------------------------------------
>40371_40371_3_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000375739_length(transcript)=5207nt_BP=754nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGAAATGACTTAATCGTCTTT
TTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGTCCCTGGG
GATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTATCTTCTGG
GGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAATGGTGAT
CTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGCATTGACC
ACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGACATTGAAT
GCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCAAAATATG
ATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGT
GCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATG
TTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCT
GATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGG
GGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATA
CCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAA
CCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGA
CATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACT
CTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAAT
CACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCA
GCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCC
ATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCT
GCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAG
CTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCT
GCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGAT
TCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCA
CGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGA
CTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAA
CTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTT
ATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGA
ATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCC
AAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCAC
ACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGAT
CAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAAC
AGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCT
TCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTC
ACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGT
TTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTG
CTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAAC
CAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATT
ACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTAAGGAGTTTTCACTGGC
CTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCACACCTAGTCATTGCTTG
AGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAGTATTCATTGAAACCAG
CTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGTGGCCGTGATTTCTTTC
TTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGATGCAGTATCAGTCTTG
TCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGAAAGTTGGGTGGCTTCA
TTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAGCTACTGAACTGCTCAC
ACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGTTAATCTCCGGCAGAGA
TGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATACTTACTATAAGTGGATT
TAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGACTACTCATTAGCGCAC
TGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAACACAGTTGCTGCACTT
GGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAGTTTTGACGGTTTACCA
TCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATAACCTGACCTTTTCTTT
GCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAAAGACAGTTCTCCTGTG
GCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATCTTCTGTTCATACAATT
CTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCCATCACCAGGCCTTTGC
AAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTTGCATAAAATTGCCAAA
ACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGGGAAAAGCCATTTTTAG
TAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATTATTGTTTGTGGTTGCA

>40371_40371_3_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000375739_length(amino acids)=538AA_BP=9
MDSQHLQTLVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMP
QMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLS
AQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITK
LEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPH
PSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILK

--------------------------------------------------------------
>40371_40371_4_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000375741_length(transcript)=5207nt_BP=754nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGAAATGACTTAATCGTCTTT
TTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGTCCCTGGG
GATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTATCTTCTGG
GGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAATGGTGAT
CTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGCATTGACC
ACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGACATTGAAT
GCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCAAAATATG
ATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGT
GCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATG
TTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCT
GATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGG
GGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATA
CCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAA
CCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGA
CATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACT
CTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAAT
CACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCA
GCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCC
ATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCT
GCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAG
CTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCT
GCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGAT
TCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCA
CGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGA
CTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAA
CTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTT
ATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGA
ATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCC
AAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCAC
ACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGAT
CAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAAC
AGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCT
TCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTC
ACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGT
TTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTG
CTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAAC
CAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATT
ACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTAAGGAGTTTTCACTGGC
CTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCACACCTAGTCATTGCTTG
AGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAGTATTCATTGAAACCAG
CTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGTGGCCGTGATTTCTTTC
TTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGATGCAGTATCAGTCTTG
TCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGAAAGTTGGGTGGCTTCA
TTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAGCTACTGAACTGCTCAC
ACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGTTAATCTCCGGCAGAGA
TGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATACTTACTATAAGTGGATT
TAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGACTACTCATTAGCGCAC
TGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAACACAGTTGCTGCACTT
GGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAGTTTTGACGGTTTACCA
TCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATAACCTGACCTTTTCTTT
GCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAAAGACAGTTCTCCTGTG
GCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATCTTCTGTTCATACAATT
CTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCCATCACCAGGCCTTTGC
AAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTTGCATAAAATTGCCAAA
ACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGGGAAAAGCCATTTTTAG
TAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATTATTGTTTGTGGTTGCA

>40371_40371_4_ITFG1-ARHGEF7_ITFG1_chr16_47399699_ENST00000544001_ARHGEF7_chr13_111896219_ENST00000375741_length(amino acids)=538AA_BP=9
MDSQHLQTLVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMP
QMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLS
AQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITK
LEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPH
PSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILK

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Fusion Gene PPI Analysis for ITFG1-ARHGEF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITFG1-ARHGEF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITFG1-ARHGEF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource