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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ITFG1-NETO2 (FusionGDB2 ID:40376)

Fusion Gene Summary for ITFG1-NETO2

Fusion gene summary

Fusion gene information	Fusion gene name: ITFG1-NETO2
	Fusion gene ID: 40376
		Hgene	Tgene
	Gene symbol	ITFG1	NETO2
	Gene ID	81533	81831
	Gene name	integrin alpha FG-GAP repeat containing 1	neuropilin and tolloid like 2
	Synonyms	2310047C21Rik\|CDA08\|LNKN-1\|TIP	BTCL2\|NEOT2
	Cytomap	16q12.1	16q12.1
	Type of gene	protein-coding	protein-coding
	Description	T-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1	neuropilin and tolloid-like protein 2brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2neuropilin (NRP) and tolloid (TLL)-like 2
	Modification date	20200313	20200313
	UniProtAcc	Q8TB96	Q8NC67
	Ensembl transtripts involved in fusion gene	ENST00000320640, ENST00000544001, ENST00000568047,	ENST00000303155, ENST00000562435,
Fusion gene scores	* DoF score	9 X 9 X 5=405	6 X 5 X 6=180
	# samples	9	8
	** MAII score	log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ITFG1 [Title/Abstract] AND NETO2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ITFG1(47409787)-NETO2(47117712), # samples:1 ITFG1(47409787)-NETO2(47120250), # samples:1
Anticipated loss of major functional domain due to fusion event.	ITFG1-NETO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ITFG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NETO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25D-01A	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
ChimerDB4	BRCA	TCGA-A2-A25D-01A	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-

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Fusion Gene ORF analysis for ITFG1-NETO2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000320640	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-
Frame-shift	ENST00000320640	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-
Frame-shift	ENST00000544001	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
Frame-shift	ENST00000544001	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-
Frame-shift	ENST00000544001	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
Frame-shift	ENST00000544001	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-
In-frame	ENST00000320640	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
In-frame	ENST00000320640	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
intron-3CDS	ENST00000568047	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
intron-3CDS	ENST00000568047	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-
intron-3CDS	ENST00000568047	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-
intron-3CDS	ENST00000568047	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47120250	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000320640	ITFG1	chr16	47409787	-	ENST00000562435	NETO2	chr16	47117712	-	7048	949	229	1053	274
ENST00000320640	ITFG1	chr16	47409787	-	ENST00000303155	NETO2	chr16	47117712	-	3117	949	229	1053	274

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000320640	ENST00000562435	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-	0.00031886	0.9996811
ENST00000320640	ENST00000303155	ITFG1	chr16	47409787	-	NETO2	chr16	47117712	-	0.000325516	0.99967444

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Fusion Genomic Features for ITFG1-NETO2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITFG1-NETO2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:47409787/chr16:47117712)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITFG1 Q8TB96	NETO2 Q8NC67
FUNCTION: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). {ECO:0000250}.	FUNCTION: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

369_525

332

526.0

Topological domain

Cytoplasmic

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

348_368

332

526.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITFG1

chr16:47409787

chr16:47117712

ENST00000320640

258_293

240

613.0

Repeat

Note=FG-GAP%3B atypical

Hgene

ITFG1

chr16:47409787

chr16:47117712

ENST00000320640

567_587

240

613.0

Transmembrane

Helical

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

177_292

332

526.0

Domain

CUB 2

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

296_332

332

526.0

Domain

LDL-receptor class A

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

45_159

332

526.0

Domain

CUB 1

Tgene

NETO2

chr16:47409787

chr16:47117712

ENST00000562435

23_347

332

526.0

Topological domain

Extracellular

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Fusion Gene Sequence for ITFG1-NETO2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40376_40376_1_ITFG1-NETO2_ITFG1_chr16_47409787_ENST00000320640_NETO2_chr16_47117712_ENST00000303155_length(transcript)=3117nt_BP=949nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGTAACGCGGTGCTTTGCGGC
TGTCGTCAAGCGCGGCGTTGGGCCGGCGGGCGGGGGCTGAGGGGCTGCCATGGCGGCGGCGGGCCGGCTCCCGAGCTCCTGGGCCCTCTT
CTCGCCGCTCCTCGCAGGGCTTGCACTACTGGGAGTCGGGCCGGTCCCAGCGCGGGCGCTGCACAACGTCACGGCCGAGCTCTTTGGGGC
CGAGGCCTGGGGCACCCTTGCGGCTTTCGGGGACCTCAACTCCGACAAGCAGACGGATCTCTTCGTGCTGCGGGAAAGAAATGACTTAAT
CGTCTTTTTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGT
CCCTGGGGATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTAT
CTTCTGGGGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAA
TGGTGATCTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGC
ATTGACCACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGAC
ATTGAATGCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGAAAAGAAAAAAGCAGGAGTATTTGAACAAATCACTAAGACT
CATGGAACAATTATTGGCATTACTTCAGGGATTGTCTTGGTCCTTCTCATTATTTCTATTTTAGTACAAGTGAAACAGCCTCGAAAAAAG
GTCATGGCTTGCAAAACCGCTTTTAATAAAACCGGGTTCCAAGAAGTGTTTGATCCTCCTCATTATGAACTGTTTTCACTAAGGGACAAA
GAGATTTCTGCAGACCTGGCAGACTTGTCGGAAGAATTGGACAACTACCAGAAGATGCGGCGCTCCTCCACCGCCTCCCGCTGCATCCAC
GACCACCACTGTGGGTCGCAGGCCTCCAGCGTCAAACAAAGCAGGACCAACCTCAGTTCCATGGAACTTCCTTTCCGAAATGACTTTGCA
CAACCACAGCCAATGAAAACATTTAATAGCACCTTCAAGAAAAGTAGTTACACTTTCAAACAGGGACATGAGTGCCCTGAGCAGGCCCTG
GAAGACCGAGTAATGGAGGAGATTCCCTGTGAAATTTATGTCAGGGGGCGAGAAGATTCTGCACAAGCATCCATATCCATTGACTTCTAA
TCTTCTGCTAATGGTGATGTGAATTCTTAGGGTGTGTACGTACGCAGCCTCCAGGGCACCATACTGTTTCCAGCAGCCAACCCTTTTCTC
CCATCACAACTACGAAGACCTTGATTTACCGTTAACCTATTGTATGGTGATGTTTTTATTCTCTCAGGCAGTCTATATATGTTAAACCAA
TCAAGGAACTTACTCTATTCAGTGGAAACAATAATCATCTCTATTGCTTGGTGTCATTTATAGGAAGCACTGCCAGTTAAAGAGCATTAG
AAGAGGTGGTTGGATGGAGCCAGGCTCAGGCTGCCTCTTCGTTTTAGCAACAAGAAGACTGCTCTTGACTGATAACAGCTCTGTCAATAT
TTTGATGCCACAATAAACTTGATTTTTCTTTACATTCCTTTTATTTTTCCTTTCTCTAAATTTAATTTGTTTTATAAGCCTATCGTTTTA
CCATTTCATTTTCTTACATAAGTACAAGTGGTTAATGTACCACATACTTCAGTATAGGCATTTGTTCTTGAGTGTGTCAAAATACAGCTA
GTTACTGTGCCAATTAAGACCCAGTTGTATTTCACCCATCTGTTTCTTCTTGGCTAATCTCTGTACTTCTGCCTTTTAATTACTGGGCCC
TTATTCCTTATTTTCTGTGAGAAATAATAGATGATATGATTTATTACCTTTCAATTATATTTTTCTCAGTTATACTAGAAAATTTCATAA
TCCTGGGATATATGTACCATTGTCAGCTATGACTAAAAATTTGAAAAAGATAAAAATTTCTAGCAAGCCTTTGAAGTTTACCAAGTATAG
TCACATTCAGTGACAGCCCATTCATTCCAGTAAAGAATCATTTCATTCACTTTGGGAGAGGCCTATAATTACATTTATTTGCAATGTTTC
TCTTCGCTAGATTGTTACATAGCTCCCATTCTGTTGGTTTTGCTTACAGCATATGGTAACCAAGGTTAGATGCCAGTTAAAATTCCTTAG
AAATTGGATGAGCCTTGAGATTGCTTCTTAACTGGGACATGACATTTTTCTAGCTCTTATCAAGAATAACAACTTCCACTTTTTTTTAAA
CTGCACTTTTGACTTTTTTTATGGTATAAAAACAATAATTTATAAACATAAAAGCTCATTGTGTTTTTTAGACTTTTGATATTATTTGAT
ACTGTACAAACTTTATTAAATCAAGATGAAAGACCTACAGGACAGATTCCTTTCAGTGTTCACATCAGTGGCTTTGTATGCAAATATGCT
GTGTTGGACCTGGACGCTATAACTTATTGTAAAGACCTTGGAAATGTGGACATAAGCTCTTTCTTTCCTTTTGTTACTGTATTTAGTTTG
TGATAAATTTTTCACTGTGTGATATTTATGCTCTAAATCACTACACAAATCCCATATTAAAATATACATTGTACCTGACCCTTTAATCAT
GTTATTTATGCCACCAAGGTTGTGGATCTTAAGGTATGTATGGAAAGGAACTCATTTATCAAATTGTAAGTAATACAGACATGCCATTTA

>40376_40376_1_ITFG1-NETO2_ITFG1_chr16_47409787_ENST00000320640_NETO2_chr16_47117712_ENST00000303155_length(amino acids)=274AA_BP=0
MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVK
VSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQ
PQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLKRKKQEYLNKSLRLMEQLLALLQGLSWSFS

--------------------------------------------------------------
>40376_40376_2_ITFG1-NETO2_ITFG1_chr16_47409787_ENST00000320640_NETO2_chr16_47117712_ENST00000562435_length(transcript)=7048nt_BP=949nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGTAACGCGGTGCTTTGCGGC
TGTCGTCAAGCGCGGCGTTGGGCCGGCGGGCGGGGGCTGAGGGGCTGCCATGGCGGCGGCGGGCCGGCTCCCGAGCTCCTGGGCCCTCTT
CTCGCCGCTCCTCGCAGGGCTTGCACTACTGGGAGTCGGGCCGGTCCCAGCGCGGGCGCTGCACAACGTCACGGCCGAGCTCTTTGGGGC
CGAGGCCTGGGGCACCCTTGCGGCTTTCGGGGACCTCAACTCCGACAAGCAGACGGATCTCTTCGTGCTGCGGGAAAGAAATGACTTAAT
CGTCTTTTTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGT
CCCTGGGGATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTAT
CTTCTGGGGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAA
TGGTGATCTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGC
ATTGACCACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGAC
ATTGAATGCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGAAAAGAAAAAAGCAGGAGTATTTGAACAAATCACTAAGACT
CATGGAACAATTATTGGCATTACTTCAGGGATTGTCTTGGTCCTTCTCATTATTTCTATTTTAGTACAAGTGAAACAGCCTCGAAAAAAG
GTCATGGCTTGCAAAACCGCTTTTAATAAAACCGGGTTCCAAGAAGTGTTTGATCCTCCTCATTATGAACTGTTTTCACTAAGGGACAAA
GAGATTTCTGCAGACCTGGCAGACTTGTCGGAAGAATTGGACAACTACCAGAAGATGCGGCGCTCCTCCACCGCCTCCCGCTGCATCCAC
GACCACCACTGTGGGTCGCAGGCCTCCAGCGTCAAACAAAGCAGGACCAACCTCAGTTCCATGGAACTTCCTTTCCGAAATGACTTTGCA
CAACCACAGCCAATGAAAACATTTAATAGCACCTTCAAGAAAAGTAGTTACACTTTCAAACAGGGACATGAGTGCCCTGAGCAGGCCCTG
GAAGACCGAGTAATGGAGGAGATTCCCTGTGAAATTTATGTCAGGGGGCGAGAAGATTCTGCACAAGCATCCATATCCATTGACTTCTAA
TCTTCTGCTAATGGTGATGTGAATTCTTAGGGTGTGTACGTACGCAGCCTCCAGGGCACCATACTGTTTCCAGCAGCCAACCCTTTTCTC
CCATCACAACTACGAAGACCTTGATTTACCGTTAACCTATTGTATGGTGATGTTTTTATTCTCTCAGGCAGTCTATATATGTTAAACCAA
TCAAGGAACTTACTCTATTCAGTGGAAACAATAATCATCTCTATTGCTTGGTGTCATTTATAGGAAGCACTGCCAGTTAAAGAGCATTAG
AAGAGGTGGTTGGATGGAGCCAGGCTCAGGCTGCCTCTTCGTTTTAGCAACAAGAAGACTGCTCTTGACTGATAACAGCTCTGTCAATAT
TTTGATGCCACAATAAACTTGATTTTTCTTTACATTCCTTTTATTTTTCCTTTCTCTAAATTTAATTTGTTTTATAAGCCTATCGTTTTA
CCATTTCATTTTCTTACATAAGTACAAGTGGTTAATGTACCACATACTTCAGTATAGGCATTTGTTCTTGAGTGTGTCAAAATACAGCTA
GTTACTGTGCCAATTAAGACCCAGTTGTATTTCACCCATCTGTTTCTTCTTGGCTAATCTCTGTACTTCTGCCTTTTAATTACTGGGCCC
TTATTCCTTATTTTCTGTGAGAAATAATAGATGATATGATTTATTACCTTTCAATTATATTTTTCTCAGTTATACTAGAAAATTTCATAA
TCCTGGGATATATGTACCATTGTCAGCTATGACTAAAAATTTGAAAAAGATAAAAATTTCTAGCAAGCCTTTGAAGTTTACCAAGTATAG
TCACATTCAGTGACAGCCCATTCATTCCAGTAAAGAATCATTTCATTCACTTTGGGAGAGGCCTATAATTACATTTATTTGCAATGTTTC
TCTTCGCTAGATTGTTACATAGCTCCCATTCTGTTGGTTTTGCTTACAGCATATGGTAACCAAGGTTAGATGCCAGTTAAAATTCCTTAG
AAATTGGATGAGCCTTGAGATTGCTTCTTAACTGGGACATGACATTTTTCTAGCTCTTATCAAGAATAACAACTTCCACTTTTTTTTAAA
CTGCACTTTTGACTTTTTTTATGGTATAAAAACAATAATTTATAAACATAAAAGCTCATTGTGTTTTTTAGACTTTTGATATTATTTGAT
ACTGTACAAACTTTATTAAATCAAGATGAAAGACCTACAGGACAGATTCCTTTCAGTGTTCACATCAGTGGCTTTGTATGCAAATATGCT
GTGTTGGACCTGGACGCTATAACTTATTGTAAAGACCTTGGAAATGTGGACATAAGCTCTTTCTTTCCTTTTGTTACTGTATTTAGTTTG
TGATAAATTTTTCACTGTGTGATATTTATGCTCTAAATCACTACACAAATCCCATATTAAAATATACATTGTACCTGACCCTTTAATCAT
GTTATTTATGCCACCAAGGTTGTGGATCTTAAGGTATGTATGGAAAGGAACTCATTTATCAAATTGTAAGTAATACAGACATGCCATTTA
AAAGAGGTAAATTCTTGTTTTCTATATTTTGTTAGTAAATTCTCAATGAAATAAGTTGAAGTTTCACTGGATTTCATTAACTTTTAAATA
TTACATATATGTGTTTTCTCAGATTAGTGAAAATTGTGACCTTAAATTTAATACACATATACTGCCTCAGAGTGCTTTCTTGTATCAAAA
TTTTTGTTTTTTAAAAAAGTAGATAATATTTAGGAGACAGAAAAACCTATACATAATGTATTCATGATTTAAATTTTTTTAAGTCAGCCT
AGTTTCTTGTTTTAAAAATATAACGTGGAAACATGAAAAGACTTGATGCATATAATATTCAATGAACTAATACCAGAGACAGCTAAGTTT
TTTCAGTAGTTATGCTGAATAAGCATTTTAGTAGGTAACTTACACCAGCTAACATTTGAACAGCATAATAAATACTTAATATAACAACAA
CTATGATCTTATGATGATAAAAGGGAAGTTAGCATATTTTCTATGTAAAATTATTCATTTTTTAAAATAGCTGTTAAACCTATATTTAAT
CTTTAGATTATAATAGCAAATAATACAGTATGCTAAACTATAGTCACTTGTAACTACATTTTTGTTTTTGAAATTTGATTTCTATTTATA
AGGTCTTGAAGAGGCCTACAAAATACAGAGCCTTTAAAGAAGACATAACAGTAAAATAGAAGTACACAGTTTTATACGAGTCAATGTAGC
AAGTAACATTTAGACAGTAAGTTTGGTTCTGAATTTTCTGGCTGCTAAAACACTTTTTGCTTTTCACAGTAAAAAAACTTATGTGCAGAG
GCTAATTTCCTCTTGAACTACAGCATGAGGGTCTGTATATAGGAACATTTCTTCAGAATGTAAAAAAGATGCAAAATGGAGACAGAGGTT
ATAATGGTGCTTCTTAACCCAGTGAAGGCACAACTTAATGTCGTCTAGGAACATTGGTTTAGGGTCAGTCTGTATTTTCAGGGATAGAAC
TAAAGAACCAGATGATCAATAGCTAAGCCAGCCTTAGCCTGTCACATGTTATACACCTTCATTGAATCATAGATGGGCATTAGATCTCAT
TTATTTATTAAACTTCTCTATGCTTTTGGAAGAGGTAAGAATGGAACTAATAAATCTTAGGCATTATTGCCAGAATAATGCTAATTGCTG
TATATACAGCCTTTAATCTTTGAGATCAGTGAGAAAACTTTATAAATTGCTTACTAAAATGAAAGCCATAAAATTTAATAACAGAAGACA
TGAAATTTAGCAATCTTGTGGAATTCATTACACAGTATTAACTGTCACGCAGGGTACCCCACACAGTGTCCCAGTGTTGAACACAAAATG
CAAATCTGGAAGGGATAAATATCTTCAATTCAGAAACAGCATTAAGTATACCTGTATAATACTGTCACCATTATCTTCCATCTGCAATTC
ACCGCATCATCCCCCAAATGCCCACAGATCTATTGCAGGAAACCTACTAATCCCAACATCTAAAGCATGTAGGAATAAGATGTGATATTC
CTTTTGTGTGTGGGGAGAGTGTCAATCTAAACGTTTAACAAAAGGCAAAGAATGTTCACATTTCACATCACAAAAGAGATTTCAAAGACT
CCTTTAACCCGACAGCGCTTATGTCAGTGTCTTTGTCATGTTTCATAGAATTGTTAGACTTTAAAAGAACCTCCTGAAAGTCTGCCTCTG
AACATTTGTATGGTTCTGCCAATGTCTGATGAGAAGAATGCTTCCCTGTTTGAGGAGTGTGTTCACTGATGAGAGGGGACGGGAGAAGCC
TGGTTGTGATTTCAGGAATAATTCTCAAAGGAGATTATACTCTTATTGCAAAATGGGGTCTGCTATATATTGTTCATGTCACTTTATTGC
AAGTGACATGAATTATATGACATTAAAAATAATATGCCTTGAATCACACTGATTAGACCCAGAAGGATCATTGAGTTTTTGGTGGTTTTA
AAGATCCAAGAAAGACCTATCTAGCCCAAGTGTATGAATGAGAAGACTGAAGCCCACAGAAGTGAACTCAGCACCAGTGTCTCAAGAACC
CCAGTACTCTGGTTTTTTTCTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAG
CTCCGCCTCCCGGGTTCACGCTATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGACTACAGGCGCCCGACACCATGCCCGGCTAATTTCT
TGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAA
GTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCTTCTGTTTTTGTTTTTCTGTTTTTTTGTTTTTTGAGACAGAGTCTCGCTCTGT
CACCCAGGCTAGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGTCTCAGCCTCTCGAG
TAGCTGGGACTACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGT
CTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAAGGCGCCCAGCCCAGCTGTAC
GTTTTAAAAGTCAAGCACTTCTGTTTAGCAGCCCATGTAAGCTTGTCAATCATTCTGAATTGAAATGTAATTTATTCTGTAATTTCTTCA
ATGCATTATATTTCCCCTTTTCTTTAAATGTATGTAACATTGTGTTCTACAGTTTTGCTGCCATGATTCCTTGGCACCGTGAATTCTTAC
TAAGCAATGTTTGTTAACAGTATACAGGCTCGATACTAGGCAGGAAGAGCTCCTGTGTTCTTGCTTTTTTGATCTTTTTTAAATCTAAAG
GAGACGTGTATTCTAGAAATTAAATATTTGTGTGCCATATCTCTTGAGTTTTGGAGAATGATTGGAGTTTGAGTTACTGTAAATAACAAG
ATTATCTTGGATATTTTAGTTTTCTGCAAAATCACTTATGTTTTATATACCTCTGCTAATAATTCAAAACTCTGAATTTGCTTTACTTTA
ACTTTTTAAAAATGTATTTTTGCAATTGGTTTAATGACTACCAAAGCCTAAAAAGCTAATGACTAGGGTGCATGTTTAGTATGCACTGTC
TAGTGTAAGCTTTTTAAAAGCAGTAGATTTTTATTAGAGATGAACTTCCAGGCCATATGAGAATATGCTTAATCCTAGATTTGGCATTTT
ATAGAAAAGAATTTTGACTCTTGAACTAGAATTAAAAACTTGTTCTGATTTCCTTGCTTGCCTCAATTTCTAAAGTCTAGAAGTGGCAAA
TAATTTAGATCACTTATACCAACAGAATCTGTATTTCCTTCCGGGGCAAAGTTGGCATTTCCTATCCACTAGCTTCCAAAATACAATAAT
CCTAGTTATGATAAGGGCAACTTTATTTTATTACACTTAGAACCATTTTATGTTTTCAAATTCATTAATCTTCAAGTGAAGATGAACTAA
AGAAAAAAATGCGTTTTGTCCCAGGTTGCCTGCAGGTTGCAGTCTGCTGCATCCGGTCACTGAAGAGGCAGTGAGGACTGTCACAGAGTG
GGCTGGAGAGCCAAGCTGTTCTTTCGGGGTGCACAGTGCACCAGCCATAACACAGCTTAGAAACATGGATGAGTATACCTCAAGACAGGT
GAACACGGAGTGGGGAGCAAAAGAAGGCAGAAACTCCTCTGAGTTTCACAAGCATCAGGCACAGATCAGGGCACAGAGGAAGAAGAAAGA
AGGTTTACCACTGGTCTGTCTCTGTAAATTGTTACAGAGCAATTTTACTTTGTGTTATTTAGGATCAAGAAACAAGTGTTATTTAAAAGT

>40376_40376_2_ITFG1-NETO2_ITFG1_chr16_47409787_ENST00000320640_NETO2_chr16_47117712_ENST00000562435_length(amino acids)=274AA_BP=0
MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVK
VSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQ
PQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLKRKKQEYLNKSLRLMEQLLALLQGLSWSFS

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Fusion Gene PPI Analysis for ITFG1-NETO2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ITFG1-NETO2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ITFG1-NETO2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source