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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITFG1-ZFC3H1 (FusionGDB2 ID:40380)

Fusion Gene Summary for ITFG1-ZFC3H1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITFG1-ZFC3H1
Fusion gene ID: 40380
HgeneTgene
Gene symbol

ITFG1

ZFC3H1

Gene ID

81533

196441

Gene nameintegrin alpha FG-GAP repeat containing 1zinc finger C3H1-type containing
Synonyms2310047C21Rik|CDA08|LNKN-1|TIPCCDC131|CSRC2|PSRC2
Cytomap

16q12.1

12q21.1

Type of geneprotein-codingprotein-coding
DescriptionT-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1zinc finger C3H1 domain-containing proteincoiled-coil domain containing 131coiled-coil domain-containing protein 131proline/serine-rich coiled-coil 2proline/serine-rich coiled-coil protein 2
Modification date2020031320200313
UniProtAcc

Q8TB96

.
Ensembl transtripts involved in fusion geneENST00000320640, ENST00000544001, 
ENST00000568047, 		ENST00000548100, 
ENST00000549407, ENST00000552037, 
ENST00000378743, 
Fusion gene scores* DoF score9 X 9 X 5=4054 X 4 X 3=48
# samples 95
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ITFG1 [Title/Abstract] AND ZFC3H1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITFG1(47252778)-ZFC3H1(72041593), # samples:1
ITFG1(47252779)-ZFC3H1(72041593), # samples:1
Anticipated loss of major functional domain due to fusion event.ITFG1-ZFC3H1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ITFG1-ZFC3H1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITFG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZFC3H1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A1EW-11BITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
ChimerDB4Non-CancerTCGA-BH-A1EW-11BITFG1chr16

47252779

-ZFC3H1chr12

72041593

-


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Fusion Gene ORF analysis for ITFG1-ZFC3H1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000320640ENST00000548100ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000320640ENST00000548100ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000320640ENST00000549407ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000320640ENST00000549407ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000320640ENST00000552037ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000320640ENST00000552037ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000548100ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000548100ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000549407ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000549407ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000552037ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5CDS-intronENST00000544001ENST00000552037ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5UTR-3CDSENST00000568047ENST00000378743ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5UTR-3CDSENST00000568047ENST00000378743ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000548100ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000548100ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000549407ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000549407ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000552037ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
5UTR-intronENST00000568047ENST00000552037ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
Frame-shiftENST00000544001ENST00000378743ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
Frame-shiftENST00000544001ENST00000378743ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-
In-frameENST00000320640ENST00000378743ITFG1chr16

47252778

-ZFC3H1chr12

72041593

-
In-frameENST00000320640ENST00000378743ITFG1chr16

47252779

-ZFC3H1chr12

72041593

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320640ITFG1chr1647252778-ENST00000378743ZFC3H1chr1272041593-7593168222966362135
ENST00000320640ITFG1chr1647252779-ENST00000378743ZFC3H1chr1272041593-7593168222966362135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320640ENST00000378743ITFG1chr1647252778-ZFC3H1chr1272041593-0.0003572240.9996427
ENST00000320640ENST00000378743ITFG1chr1647252779-ZFC3H1chr1272041593-0.0003572240.9996427

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Fusion Genomic Features for ITFG1-ZFC3H1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITFG1-ZFC3H1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:47252778/chr12:72041593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITFG1

Q8TB96

.
FUNCTION: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITFG1chr16:47252778chr12:72041593ENST00000320640-1418258_293484613.0RepeatNote=FG-GAP%3B atypical
HgeneITFG1chr16:47252779chr12:72041593ENST00000320640-1418258_293484613.0RepeatNote=FG-GAP%3B atypical
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135358_3893381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135432_4873381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135847_9093381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135965_9893381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002219_2590347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002358_3890347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002432_4870347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002847_9090347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002965_9890347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135358_3893381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135432_4873381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135847_9093381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135965_9893381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002219_2590347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002358_3890347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002432_4870347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002847_9090347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002965_9890347.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135542_6163381990.0Compositional biasNote=Pro-rich
TgeneZFC3H1chr16:47252778chr12:72041593ENST000005481000234_1320347.0Compositional biasNote=Ser-rich
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000054810002542_6160347.0Compositional biasNote=Pro-rich
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135542_6163381990.0Compositional biasNote=Pro-rich
TgeneZFC3H1chr16:47252779chr12:72041593ENST000005481000234_1320347.0Compositional biasNote=Ser-rich
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000054810002542_6160347.0Compositional biasNote=Pro-rich
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351361_14003381990.0RepeatNote=TPR 1
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351401_14343381990.0RepeatNote=TPR 2
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351438_14713381990.0RepeatNote=TPR 3
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351478_15113381990.0RepeatNote=TPR 4
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351602_16353381990.0RepeatNote=TPR 5
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351636_16693381990.0RepeatNote=TPR 6
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351745_17783381990.0RepeatNote=TPR 7
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021361_14000347.0RepeatNote=TPR 1
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021401_14340347.0RepeatNote=TPR 2
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021438_14710347.0RepeatNote=TPR 3
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021478_15110347.0RepeatNote=TPR 4
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021602_16350347.0RepeatNote=TPR 5
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021636_16690347.0RepeatNote=TPR 6
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021745_17780347.0RepeatNote=TPR 7
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351361_14003381990.0RepeatNote=TPR 1
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351401_14343381990.0RepeatNote=TPR 2
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351438_14713381990.0RepeatNote=TPR 3
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351478_15113381990.0RepeatNote=TPR 4
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351602_16353381990.0RepeatNote=TPR 5
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351636_16693381990.0RepeatNote=TPR 6
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351745_17783381990.0RepeatNote=TPR 7
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021361_14000347.0RepeatNote=TPR 1
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021401_14340347.0RepeatNote=TPR 2
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021438_14710347.0RepeatNote=TPR 3
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021478_15110347.0RepeatNote=TPR 4
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021602_16350347.0RepeatNote=TPR 5
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021636_16690347.0RepeatNote=TPR 6
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021745_17780347.0RepeatNote=TPR 7
TgeneZFC3H1chr16:47252778chr12:72041593ENST000003787431351185_12063381990.0Zinc fingerNote=C3H1-type
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000548100021185_12060347.0Zinc fingerNote=C3H1-type
TgeneZFC3H1chr16:47252779chr12:72041593ENST000003787431351185_12063381990.0Zinc fingerNote=C3H1-type
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000548100021185_12060347.0Zinc fingerNote=C3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITFG1chr16:47252778chr12:72041593ENST00000320640-1418567_587484613.0TransmembraneHelical
HgeneITFG1chr16:47252779chr12:72041593ENST00000320640-1418567_587484613.0TransmembraneHelical
TgeneZFC3H1chr16:47252778chr12:72041593ENST00000378743135219_2593381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252779chr12:72041593ENST00000378743135219_2593381990.0Coiled coilOntology_term=ECO:0000255
TgeneZFC3H1chr16:47252778chr12:72041593ENST0000037874313534_1323381990.0Compositional biasNote=Ser-rich
TgeneZFC3H1chr16:47252779chr12:72041593ENST0000037874313534_1323381990.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for ITFG1-ZFC3H1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40380_40380_1_ITFG1-ZFC3H1_ITFG1_chr16_47252778_ENST00000320640_ZFC3H1_chr12_72041593_ENST00000378743_length(transcript)=7593nt_BP=1682nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGTAACGCGGTGCTTTGCGGC
TGTCGTCAAGCGCGGCGTTGGGCCGGCGGGCGGGGGCTGAGGGGCTGCCATGGCGGCGGCGGGCCGGCTCCCGAGCTCCTGGGCCCTCTT
CTCGCCGCTCCTCGCAGGGCTTGCACTACTGGGAGTCGGGCCGGTCCCAGCGCGGGCGCTGCACAACGTCACGGCCGAGCTCTTTGGGGC
CGAGGCCTGGGGCACCCTTGCGGCTTTCGGGGACCTCAACTCCGACAAGCAGACGGATCTCTTCGTGCTGCGGGAAAGAAATGACTTAAT
CGTCTTTTTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGT
CCCTGGGGATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTAT
CTTCTGGGGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAA
TGGTGATCTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGC
ATTGACCACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGAC
ATTGAATGCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCA
AAATATGATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGATGGAGATGGACACATGGATCATTTACTGCCAGGCTGTGAAGATAAAAA
TTGCCAAAAGAGTACCATCTACTTAGTGAGATCTGGGATGAAGCAGTGGGTTCCAGTCCTACAAGATTTCAGCAATAAGGGCACACTCTG
GGGCTTTGTGCCATTTGTGGATGAACAGCAACCAACTGAAATACCAATTCCAATTACCCTTCATATTGGAGACTACAATATGGATGGCTA
TCCAGACGCTCTGGTCATACTAAAGAACACATCTGGAAGCAACCAGCAGGCCTTTTTACTGGAGAACGTCCCTTGTAATAATGCAAGCTG
TGAAGAGGCGCGTCGAATGTTTAAAGTCTACTGGGAGCTGACAGACCTAAATCAAATTAAGGATGCCATGGTTGCCACCTTCTTTGACAT
TTACGAAGATGGAATCTTGGACATTGTAGTGCTAAGTAAAGGATATACAAAGAATGATTTTGCCATTCATACACTAAAAAATAACTTTGA
AGCAGATGCTTATTTTGTTAAAGTTATTGTTCTTAGTGGTCTGTGTTCTAATGACTGTCCTCGTAAGATAACACCCTTTGGAGTGAATCA
ACCTGGACCTTATATCATGTATACAACTGTAGATGCAAATGGGTATCTGAAAAATGGATCAGGATTACAAGATAAAGAACAAAATTTAAC
AAGAAGAATTAGTACCTCAGATATTCTGTCTGAAAAGAAACTTGGTGAAGATGAAGAGGAACTATCTGAATTACAGCTTCGCCTTTTGGC
TCTTCAGTCAGCCAGTAAAAAATGGCAACAAAAAGAACAGCAGGTGATGAAAGAAAGCAAAGAAAAGTTGACTAAGACGAAAACTGTACA
GCAAAAAGTTAAAACAAGTACAAAAACACATTCGGCCAAAAAAGTTAGCACTACAGCTAAACAAGCATTGAGGAAGCAGCAAACAAAGGC
ATGGAAGAAACTACAACAACAAAAAGAGCAGGAAAGACAGAAAGAAGAGGATCAGCGGAAACAAGCTGAAGAAGAAGAGAGAAGGAAAAG
AGAGGAAGAAATCAGAAAAATTCGAGATCTCTCAAATCAGGAAGAACAGTACAATCGATTCATGAAATTGGTTGGTGGCAAGAGGAGATC
AAGAAGTAAATCTTCAGATCCTGACCTGAGGCGATCCTTAGATAAGCAACCTACTGATAGTGGAGGAGGCATTTATCAGTATGATAACTA
TGAAGAAGTTGCTATGGATACAGATAGTGAAACCAGTTCTCCAGCTCCTTCACCAGTGCAACCGCCATTTTTCTCTGAATGTTCATTGGG
GTATTTTTCTCCAGCACCATCTCTTTCTTTGCCTCCACCACCTCAGGTTTCTTCTCTGCCACCTTTGAGCCAGCCTTATGTGGAAGGCTT
GTGTGTTTCTCTTGAACCTCTACCTCCTCTACCACCATTACCACCTCTCCCACCTGAAGATCCAGAACAGCCTCCAAAACCACCTTTTGC
AGATGAGGAAGAGGAGGAAGAAATGCTGCTTCGAGAAGAACTACTTAAATCTCTAGCAAATAAAAGAGCTTTTAAGCCAGAGGAAACATC
CAGTAATAGTGACCCACCTTCACCTCCAGTTCTGAACAATTCACATCCTGTGCCAAGAAGCAATCTATCAATAGTCAGTATTAACACAGT
GTCTCAGCCTAGGATACAGAATCCAAAGTTTCACAGAGGACCCCGTCTTCCACGAACTGTGATCTCGCTTCCAAAGCATAAATCAGTGGT
TGTAACACTAAATGATTCAGATGATAGTGAATCTGATGGAGAGGCTTCCAAGTCAACAAATAGTGTTTTTGGTGGATTAGAGTCCATGAT
TAAAGAAGCAAGACGAACTGCTGAGCAAGCTTCAAAACCGAAAGTACCTCCAAAATCTGAAAAAGAAAATGATCCTCTGCGAACACCGGA
GGCTTTGCCTGAAGAAAAGAAGATTGAATATAGATTGTTAAAGGAAGAGATTGCCAACCGTGAGAAACAGCGTTTGATTAAATCAGATCA
GCTGAAGACAAGTTCATCATCCCCAGCAAACTCTGATGTGGAAATTGATGGTATTGGCAGGATAGCAATGGTTACTAAGCAGGTTACAGA
TGCAGAATCAAAACTGAAAAAACATAGGATTCTCTTGATGAAAGATGAATCTGTTTTAAAGAATTTAGTGCAACAAGAAGCTAAGAAGAA
AGAATCTGTTAGAAATGCTGAAGCAAAGATTACAAAACTTACAGAACAGCTTCAAGCAACTGAAAAAATTCTTAATGTTAACAGAATGTT
TTTGAAGAAGCTTCAGGAACAAATTCACAGAGTTCAACAGCGTGTTACAATTAAGAAAGCTTTGACTCTAAAATATGGAGAAGAGCTTGC
TCGGGCAAAGGCAGTGGCCAGTAAAGAAATAGGAAAACGTAAACTGGAACAAGATCGCTTTGGGCCAAACAAAATGATGAGACTGGACAG
TTCTCCAGTATCAAGTCCAAGAAAGCATTCAGCAGAACTAATTGCTATGGAGAAAAGACGGTTACAAAAGCTAGAATATGAATATGCCCT
GAAAATTCAAAAATTAAAAGAAGCCCGTGCCCTTAAAGCAAAGGAACAACAAAATATCTCTCCAGTTGTGGAAGAGGAACCCGAATTTTC
TTTACCTCAACCCTCACTTCATGATCTGACACAAGATAAATTAACCCTGGACACTGAAGAAAATGATGTTGATGATGAAATTTTGTCTGG
TTCAAGCAGAGAGCGAAGAAGATCTTTTTTAGAATCCAATTATTTTACTAAACCTAACCTTAAGCACACTGATACTGCTAACAAAGAATG
CATAAACAAACTTAATAAAAATACTGTAGAAAAACCAGAACTTTTTCTAGGGTTAAAAATTGGTGAATTGCAAAAATTGTATTCAAAAGC
TGACAGCCTAAAACAGCTGATTTTAAAAACCACCACAGGCATTACAGAGAAGGTTTTGCATGGTCAGGAGATTTCTGTAGATGTGGATTT
TGTCACAGCACAAAGTAAAACAATGGAAGTGAAGCCATGTCCTTTTAGACCCTACCATAGTCCTCTTCTAGTTTTTAAGTCCTACAGATT
TAGTCCATATTATCGAACCAAGGAAAAACTTCCCCTGAGCTCAGTATCATACAGTAATATGATTGAACCGGATCAGTGTTTCTGCCGTTT
TGATTTAACAGGAACATGTAATGATGATGATTGTCAATGGCAGCATATACAAGACTATACACTTAGCCGAAAACAGTTATTCCAGGACAT
TCTGTCATATAATCTGTCTTTGATTGGTTGTGCAGAGACAAGTACTAATGAAGAAATTACTGCTTCAGCAGAAAAATATGTTGAGAAACT
TTTTGGAGTAAACAAAGATCGAATGTCAATGGACCAGATGGCTGTTCTCCTTGTTAGCAATATCAATGAAAGTAAAGGTCATACTCCTCC
ATTTACAACCTACAAAGATAAAAGAAAGTGGAAGCCAAAGTTTTGGAGAAAACCTATTTCAGATAATAGCTTCAGTAGTGATGAGGAACA
GTCTACAGGACCAATTAAGTATGCTTTCCAGCCAGAGAACCAAATAAATGTTCCAGCTCTGGATACAGTTGTCACTCCAGATGATGTCAG
ATACTTTACAAATGAGACTGATGACATCGCTAATTTAGAAGCAAGTGTGCTTGAAAATCCTTCTCATGTACAACTTTGGCTCAAGCTTGC
GTACAAGTACTTGAATCAAAATGAGGGGGAGTGCTCAGAATCCTTGGATTCTGCTTTAAATGTTCTGGCGCGAGCATTGGAAAATAACAA
AGACAATCCAGAAATTTGGTGCCATTACCTCAGATTGTTCTCAAAAAGAGGAACCAAGGACGAGGTGCAGGAAATGTGTGAAACAGCTGT
TGAATATGCTCCAGATTATCAAAGCTTTTGGACTTTTCTACACCTAGAAAGTACCTTTGAAGAAAAGGATTACGTATGTGAGAGAATGTT
GGAGTTTCTGATGGGAGCAGCCAAGCAGGAAACATCCAATATTTTGTCCTTTCAGCTTTTAGAGGCTCTTTTGTTTAGAGTTCAGCTGCA
CATATTTACTGGAAGATGCCAAAGTGCACTGGCAATTTTACAGAATGCATTGAAATCTGCTAATGATGGAATAGTAGCTGAATACCTTAA
AACCAGTGATCGATGTTTGGCATGGTTGGCCTACATACATCTTATTGAATTCAACATTCTCCCTTCAAAATTTTATGATCCATCTAATGA
TAATCCTTCAAGAATTGTTAACACTGAATCATTTGTAATGCCATGGCAAGCTGTTCAAGATGTAAAGACTAATCCTGACATGTTGTTAGC
AGTTTTTGAAGATGCAGTGAAAGCTTGCACAGATGAGAGCCTTGCTGTTGAGGAAAGAATAGAGGCCTGCCTTCCACTTTACACAAACAT
GATTGCTCTGCACCAACTCCTGGAGAGGTATGAGGCTGCAATGGAGCTTTGTAAATCTTTATTGGAATCATGTCCTATTAACTGCCAGTT
GCTGGAAGCTCTTGTTGCATTATATTTGCAAACAAATCAGCATGACAAAGCCAGAGCAGTGTGGCTTACTGCATTTGAAAAAAATCCTCA
GAATGCAGAGGTTTTTTATCATATGTGCAAATTCTTCATCTTACAGAATCGAGGCGATAATCTTCTTCCATTTTTGCGGAAATTTATTGC
ATCCTTCTTTAAACCGGGGTTTGAGAAGTATAATAACTTGGATCTGTTTCGGTATCTCTTAAATATTCCAGGACCAATTGACATTCCATC
TCGTTTATGTAAAGGGAATTTTGATGATGATATGTTTAACCACCAAGTTCCTTATTTGTGGCTGATTTACTGCCTTTGTCATCCTCTTCA
ATCAAGTATTAAAGAAACAGTGGAGGCATATGAGGCAGCATTAGGGGTGGCTATGAGATGTGATATAGTACAGAAGATATGGATGGATTA
TCTTGTCTTTGCAAATAATAGAGCTGCTGGATCCAGAAACAAAGTTCAAGAATTCAAATTTTTTACTGATTTAGTGAATAGATGTTTGGT
TACAGTCCCTGCCCGATACCCCATTCCTTTTAGCAGTGCTGATTACTGGTCCAACTATGAATTTCATAATAGGGTTATTTTCTTTTATTT
GAGCTGTGTTCCAAAGACCCAGCATTCCAAAACCTTGGAACGGTTTTGTTCAGTTATGCCAGCTAATTCTGGACTTGCATTGAGGTTACT
TCAACATGAATGGGAAGAAAGCAATGTTCAGATTCTGAAACTTCAAGCCAAGATGTTTACATATAATATCCCAACATGCCTGGCCACCTG
GAAAATAGCCATTGCTGCTGAGATTGTTCTAAAGGGACAAAGAGAGGTCCACCGTTTATATCAGAGAGCCTTACAGAAGTTACCTCTTTG
TGCATCACTGTGGAAAGATCAACTCTTGTTTGAAGCATCAGAAGGAGGTAAAACTGATAACCTGAGAAAACTAGTTTCCAAGTGCCAAGA
GATTGGAGTCAGCCTAAATGAGCTCTTAAATTTAAACAGTAACAAAACAGAAAGCAAGAATCACTGAACACTGGGTGCAGTCAGTTCTAA
GTCCTTATAATAATTGCCAAAATTATTTGAATGATTCTTCAAGATTAGGCTGATCCCTGGCTAAGGTCTGTGTAAGGCAGACAAGCGTTA
TTGATCATATCAAGTTCCCTACAATATCCTGTCCTCAAAACCGGAAGCAATGAACATGATCCTCTTCGGTTGGATAAATGAACTTCCTGT
TTGGCCTGCTTCTAGGCCCTGCCAGATTCTCATAACATCATATACGTAAGTATAGTTCCTCAAAGTGACTGACATTTATTTTAATTTTGC
TTTGTTTTTTTTTATTTTCTCCCCCATTCCTTTATTTTGTGTTATTCCTGACTCACTTGACACTCTCTGATGCCTGAGAGATTCCTGTTT
GGGATTTAATATCCAGGGCTGTGTTTACAGTAAAAAAAGCAGGCAGTCCCTTTTAGTTTTTCCTTTTTAAATTTTTTTGAGATTCTTCAT
TTCAGGATTTAAAACTATAGCAGTCCATCTTAAGGAAAGTGTAACTGCCATGGCCACAAGTCTGCTAGTTGCACTTGAATGCTCTATCAG
GGTTGTTTATTACCCTTTCTACGTTCTGGACTCCTTGCCGAGACTGTTTAACTTGAAGATTAAAGAAACTATTGCAAATGCCAGTGCATC
AGAACCTAAGAGTGGTCAAATATTATGTGCAATTTTTTTGTAAAGAAATTTTAATTTATAATAAAGTTTAACAGTTTAAAGAACAGTTAA
TATTTGAACTGCTTTGTATTGAAATACTACTTTGTAGTATTGAAATTGTTTATATACTTTTTTAATATAAGTTAACTTTCTAAAAACTCT
TGCTGTCTTTATTCACTTTTCACACTGGTGGGAAAGGGTTGAAGTCGGAGATACGGATATTCACCATAACTTATAGCAATACTTTTTTAT

>40380_40380_1_ITFG1-ZFC3H1_ITFG1_chr16_47252778_ENST00000320640_ZFC3H1_chr12_72041593_ENST00000378743_length(amino acids)=2135AA_BP=484
MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVK
VSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQ
PQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGD
GHMDHLLPGCEDKNCQKSTIYLVRSGMKQWVPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQ
AFLLENVPCNNASCEEARRMFKVYWELTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCS
NDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVM
KESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQ
YNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQV
SSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHP
VPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVP
PKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDE
SVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLE
QDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTL
DTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITE
KVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHI
QDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWR
KPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLD
SALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILS
FQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQ
AVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDK
ARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQV
PYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYW
SNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREV

--------------------------------------------------------------
>40380_40380_2_ITFG1-ZFC3H1_ITFG1_chr16_47252779_ENST00000320640_ZFC3H1_chr12_72041593_ENST00000378743_length(transcript)=7593nt_BP=1682nt
ACTGTCGGGAGGCGCGCCTGCCGGAAGTGAGCGTGAGGGCGGCTTTCACCCTAGCTCCACTGCTTTTTTAGCGTCGGAAGGGCAGCCCTA
GTGGGAGAGAGAAAAAGGAGCCGGCAGCGGCTCTTACGCGTCCCGGGGCTGCGCGCCACTCTCTCGGCCGGTAACGCGGTGCTTTGCGGC
TGTCGTCAAGCGCGGCGTTGGGCCGGCGGGCGGGGGCTGAGGGGCTGCCATGGCGGCGGCGGGCCGGCTCCCGAGCTCCTGGGCCCTCTT
CTCGCCGCTCCTCGCAGGGCTTGCACTACTGGGAGTCGGGCCGGTCCCAGCGCGGGCGCTGCACAACGTCACGGCCGAGCTCTTTGGGGC
CGAGGCCTGGGGCACCCTTGCGGCTTTCGGGGACCTCAACTCCGACAAGCAGACGGATCTCTTCGTGCTGCGGGAAAGAAATGACTTAAT
CGTCTTTTTGGCAGACCAGAATGCACCCTATTTTAAACCCAAAGTAAAGGTATCTTTCAAGAATCACAGTGCATTGATAACAAGTGTAGT
CCCTGGGGATTATGATGGAGATTCTCAAATGGATGTCCTTCTGACATATCTTCCCAAAAATTATGCCAAGAGTGAATTAGGAGCTGTTAT
CTTCTGGGGACAAAATCAAACATTAGATCCTAACAATATGACCATACTCAATAGGACTTTTCAAGATGAGCCACTAATTATGGATTTCAA
TGGTGATCTAATTCCTGATATTTTTGGTATCACAAATGAATCCAACCAGCCACAGATACTATTAGGAGGGAATTTATCATGGCATCCAGC
ATTGACCACTACAAGTAAAATGCGAATTCCACATTCTCATGCATTTATTGATCTGACTGAAGATTTTACAGCAGATTTATTCCTGACGAC
ATTGAATGCCACCACTAGTACCTTCCAGTTTGAAATATGGGAAAATTTGGATGGAAACTTCTCTGTCAGTACTATATTGGAAAAACCTCA
AAATATGATGGTGGTTGGACAGTCAGCATTTGCAGACTTTGATGGAGATGGACACATGGATCATTTACTGCCAGGCTGTGAAGATAAAAA
TTGCCAAAAGAGTACCATCTACTTAGTGAGATCTGGGATGAAGCAGTGGGTTCCAGTCCTACAAGATTTCAGCAATAAGGGCACACTCTG
GGGCTTTGTGCCATTTGTGGATGAACAGCAACCAACTGAAATACCAATTCCAATTACCCTTCATATTGGAGACTACAATATGGATGGCTA
TCCAGACGCTCTGGTCATACTAAAGAACACATCTGGAAGCAACCAGCAGGCCTTTTTACTGGAGAACGTCCCTTGTAATAATGCAAGCTG
TGAAGAGGCGCGTCGAATGTTTAAAGTCTACTGGGAGCTGACAGACCTAAATCAAATTAAGGATGCCATGGTTGCCACCTTCTTTGACAT
TTACGAAGATGGAATCTTGGACATTGTAGTGCTAAGTAAAGGATATACAAAGAATGATTTTGCCATTCATACACTAAAAAATAACTTTGA
AGCAGATGCTTATTTTGTTAAAGTTATTGTTCTTAGTGGTCTGTGTTCTAATGACTGTCCTCGTAAGATAACACCCTTTGGAGTGAATCA
ACCTGGACCTTATATCATGTATACAACTGTAGATGCAAATGGGTATCTGAAAAATGGATCAGGATTACAAGATAAAGAACAAAATTTAAC
AAGAAGAATTAGTACCTCAGATATTCTGTCTGAAAAGAAACTTGGTGAAGATGAAGAGGAACTATCTGAATTACAGCTTCGCCTTTTGGC
TCTTCAGTCAGCCAGTAAAAAATGGCAACAAAAAGAACAGCAGGTGATGAAAGAAAGCAAAGAAAAGTTGACTAAGACGAAAACTGTACA
GCAAAAAGTTAAAACAAGTACAAAAACACATTCGGCCAAAAAAGTTAGCACTACAGCTAAACAAGCATTGAGGAAGCAGCAAACAAAGGC
ATGGAAGAAACTACAACAACAAAAAGAGCAGGAAAGACAGAAAGAAGAGGATCAGCGGAAACAAGCTGAAGAAGAAGAGAGAAGGAAAAG
AGAGGAAGAAATCAGAAAAATTCGAGATCTCTCAAATCAGGAAGAACAGTACAATCGATTCATGAAATTGGTTGGTGGCAAGAGGAGATC
AAGAAGTAAATCTTCAGATCCTGACCTGAGGCGATCCTTAGATAAGCAACCTACTGATAGTGGAGGAGGCATTTATCAGTATGATAACTA
TGAAGAAGTTGCTATGGATACAGATAGTGAAACCAGTTCTCCAGCTCCTTCACCAGTGCAACCGCCATTTTTCTCTGAATGTTCATTGGG
GTATTTTTCTCCAGCACCATCTCTTTCTTTGCCTCCACCACCTCAGGTTTCTTCTCTGCCACCTTTGAGCCAGCCTTATGTGGAAGGCTT
GTGTGTTTCTCTTGAACCTCTACCTCCTCTACCACCATTACCACCTCTCCCACCTGAAGATCCAGAACAGCCTCCAAAACCACCTTTTGC
AGATGAGGAAGAGGAGGAAGAAATGCTGCTTCGAGAAGAACTACTTAAATCTCTAGCAAATAAAAGAGCTTTTAAGCCAGAGGAAACATC
CAGTAATAGTGACCCACCTTCACCTCCAGTTCTGAACAATTCACATCCTGTGCCAAGAAGCAATCTATCAATAGTCAGTATTAACACAGT
GTCTCAGCCTAGGATACAGAATCCAAAGTTTCACAGAGGACCCCGTCTTCCACGAACTGTGATCTCGCTTCCAAAGCATAAATCAGTGGT
TGTAACACTAAATGATTCAGATGATAGTGAATCTGATGGAGAGGCTTCCAAGTCAACAAATAGTGTTTTTGGTGGATTAGAGTCCATGAT
TAAAGAAGCAAGACGAACTGCTGAGCAAGCTTCAAAACCGAAAGTACCTCCAAAATCTGAAAAAGAAAATGATCCTCTGCGAACACCGGA
GGCTTTGCCTGAAGAAAAGAAGATTGAATATAGATTGTTAAAGGAAGAGATTGCCAACCGTGAGAAACAGCGTTTGATTAAATCAGATCA
GCTGAAGACAAGTTCATCATCCCCAGCAAACTCTGATGTGGAAATTGATGGTATTGGCAGGATAGCAATGGTTACTAAGCAGGTTACAGA
TGCAGAATCAAAACTGAAAAAACATAGGATTCTCTTGATGAAAGATGAATCTGTTTTAAAGAATTTAGTGCAACAAGAAGCTAAGAAGAA
AGAATCTGTTAGAAATGCTGAAGCAAAGATTACAAAACTTACAGAACAGCTTCAAGCAACTGAAAAAATTCTTAATGTTAACAGAATGTT
TTTGAAGAAGCTTCAGGAACAAATTCACAGAGTTCAACAGCGTGTTACAATTAAGAAAGCTTTGACTCTAAAATATGGAGAAGAGCTTGC
TCGGGCAAAGGCAGTGGCCAGTAAAGAAATAGGAAAACGTAAACTGGAACAAGATCGCTTTGGGCCAAACAAAATGATGAGACTGGACAG
TTCTCCAGTATCAAGTCCAAGAAAGCATTCAGCAGAACTAATTGCTATGGAGAAAAGACGGTTACAAAAGCTAGAATATGAATATGCCCT
GAAAATTCAAAAATTAAAAGAAGCCCGTGCCCTTAAAGCAAAGGAACAACAAAATATCTCTCCAGTTGTGGAAGAGGAACCCGAATTTTC
TTTACCTCAACCCTCACTTCATGATCTGACACAAGATAAATTAACCCTGGACACTGAAGAAAATGATGTTGATGATGAAATTTTGTCTGG
TTCAAGCAGAGAGCGAAGAAGATCTTTTTTAGAATCCAATTATTTTACTAAACCTAACCTTAAGCACACTGATACTGCTAACAAAGAATG
CATAAACAAACTTAATAAAAATACTGTAGAAAAACCAGAACTTTTTCTAGGGTTAAAAATTGGTGAATTGCAAAAATTGTATTCAAAAGC
TGACAGCCTAAAACAGCTGATTTTAAAAACCACCACAGGCATTACAGAGAAGGTTTTGCATGGTCAGGAGATTTCTGTAGATGTGGATTT
TGTCACAGCACAAAGTAAAACAATGGAAGTGAAGCCATGTCCTTTTAGACCCTACCATAGTCCTCTTCTAGTTTTTAAGTCCTACAGATT
TAGTCCATATTATCGAACCAAGGAAAAACTTCCCCTGAGCTCAGTATCATACAGTAATATGATTGAACCGGATCAGTGTTTCTGCCGTTT
TGATTTAACAGGAACATGTAATGATGATGATTGTCAATGGCAGCATATACAAGACTATACACTTAGCCGAAAACAGTTATTCCAGGACAT
TCTGTCATATAATCTGTCTTTGATTGGTTGTGCAGAGACAAGTACTAATGAAGAAATTACTGCTTCAGCAGAAAAATATGTTGAGAAACT
TTTTGGAGTAAACAAAGATCGAATGTCAATGGACCAGATGGCTGTTCTCCTTGTTAGCAATATCAATGAAAGTAAAGGTCATACTCCTCC
ATTTACAACCTACAAAGATAAAAGAAAGTGGAAGCCAAAGTTTTGGAGAAAACCTATTTCAGATAATAGCTTCAGTAGTGATGAGGAACA
GTCTACAGGACCAATTAAGTATGCTTTCCAGCCAGAGAACCAAATAAATGTTCCAGCTCTGGATACAGTTGTCACTCCAGATGATGTCAG
ATACTTTACAAATGAGACTGATGACATCGCTAATTTAGAAGCAAGTGTGCTTGAAAATCCTTCTCATGTACAACTTTGGCTCAAGCTTGC
GTACAAGTACTTGAATCAAAATGAGGGGGAGTGCTCAGAATCCTTGGATTCTGCTTTAAATGTTCTGGCGCGAGCATTGGAAAATAACAA
AGACAATCCAGAAATTTGGTGCCATTACCTCAGATTGTTCTCAAAAAGAGGAACCAAGGACGAGGTGCAGGAAATGTGTGAAACAGCTGT
TGAATATGCTCCAGATTATCAAAGCTTTTGGACTTTTCTACACCTAGAAAGTACCTTTGAAGAAAAGGATTACGTATGTGAGAGAATGTT
GGAGTTTCTGATGGGAGCAGCCAAGCAGGAAACATCCAATATTTTGTCCTTTCAGCTTTTAGAGGCTCTTTTGTTTAGAGTTCAGCTGCA
CATATTTACTGGAAGATGCCAAAGTGCACTGGCAATTTTACAGAATGCATTGAAATCTGCTAATGATGGAATAGTAGCTGAATACCTTAA
AACCAGTGATCGATGTTTGGCATGGTTGGCCTACATACATCTTATTGAATTCAACATTCTCCCTTCAAAATTTTATGATCCATCTAATGA
TAATCCTTCAAGAATTGTTAACACTGAATCATTTGTAATGCCATGGCAAGCTGTTCAAGATGTAAAGACTAATCCTGACATGTTGTTAGC
AGTTTTTGAAGATGCAGTGAAAGCTTGCACAGATGAGAGCCTTGCTGTTGAGGAAAGAATAGAGGCCTGCCTTCCACTTTACACAAACAT
GATTGCTCTGCACCAACTCCTGGAGAGGTATGAGGCTGCAATGGAGCTTTGTAAATCTTTATTGGAATCATGTCCTATTAACTGCCAGTT
GCTGGAAGCTCTTGTTGCATTATATTTGCAAACAAATCAGCATGACAAAGCCAGAGCAGTGTGGCTTACTGCATTTGAAAAAAATCCTCA
GAATGCAGAGGTTTTTTATCATATGTGCAAATTCTTCATCTTACAGAATCGAGGCGATAATCTTCTTCCATTTTTGCGGAAATTTATTGC
ATCCTTCTTTAAACCGGGGTTTGAGAAGTATAATAACTTGGATCTGTTTCGGTATCTCTTAAATATTCCAGGACCAATTGACATTCCATC
TCGTTTATGTAAAGGGAATTTTGATGATGATATGTTTAACCACCAAGTTCCTTATTTGTGGCTGATTTACTGCCTTTGTCATCCTCTTCA
ATCAAGTATTAAAGAAACAGTGGAGGCATATGAGGCAGCATTAGGGGTGGCTATGAGATGTGATATAGTACAGAAGATATGGATGGATTA
TCTTGTCTTTGCAAATAATAGAGCTGCTGGATCCAGAAACAAAGTTCAAGAATTCAAATTTTTTACTGATTTAGTGAATAGATGTTTGGT
TACAGTCCCTGCCCGATACCCCATTCCTTTTAGCAGTGCTGATTACTGGTCCAACTATGAATTTCATAATAGGGTTATTTTCTTTTATTT
GAGCTGTGTTCCAAAGACCCAGCATTCCAAAACCTTGGAACGGTTTTGTTCAGTTATGCCAGCTAATTCTGGACTTGCATTGAGGTTACT
TCAACATGAATGGGAAGAAAGCAATGTTCAGATTCTGAAACTTCAAGCCAAGATGTTTACATATAATATCCCAACATGCCTGGCCACCTG
GAAAATAGCCATTGCTGCTGAGATTGTTCTAAAGGGACAAAGAGAGGTCCACCGTTTATATCAGAGAGCCTTACAGAAGTTACCTCTTTG
TGCATCACTGTGGAAAGATCAACTCTTGTTTGAAGCATCAGAAGGAGGTAAAACTGATAACCTGAGAAAACTAGTTTCCAAGTGCCAAGA
GATTGGAGTCAGCCTAAATGAGCTCTTAAATTTAAACAGTAACAAAACAGAAAGCAAGAATCACTGAACACTGGGTGCAGTCAGTTCTAA
GTCCTTATAATAATTGCCAAAATTATTTGAATGATTCTTCAAGATTAGGCTGATCCCTGGCTAAGGTCTGTGTAAGGCAGACAAGCGTTA
TTGATCATATCAAGTTCCCTACAATATCCTGTCCTCAAAACCGGAAGCAATGAACATGATCCTCTTCGGTTGGATAAATGAACTTCCTGT
TTGGCCTGCTTCTAGGCCCTGCCAGATTCTCATAACATCATATACGTAAGTATAGTTCCTCAAAGTGACTGACATTTATTTTAATTTTGC
TTTGTTTTTTTTTATTTTCTCCCCCATTCCTTTATTTTGTGTTATTCCTGACTCACTTGACACTCTCTGATGCCTGAGAGATTCCTGTTT
GGGATTTAATATCCAGGGCTGTGTTTACAGTAAAAAAAGCAGGCAGTCCCTTTTAGTTTTTCCTTTTTAAATTTTTTTGAGATTCTTCAT
TTCAGGATTTAAAACTATAGCAGTCCATCTTAAGGAAAGTGTAACTGCCATGGCCACAAGTCTGCTAGTTGCACTTGAATGCTCTATCAG
GGTTGTTTATTACCCTTTCTACGTTCTGGACTCCTTGCCGAGACTGTTTAACTTGAAGATTAAAGAAACTATTGCAAATGCCAGTGCATC
AGAACCTAAGAGTGGTCAAATATTATGTGCAATTTTTTTGTAAAGAAATTTTAATTTATAATAAAGTTTAACAGTTTAAAGAACAGTTAA
TATTTGAACTGCTTTGTATTGAAATACTACTTTGTAGTATTGAAATTGTTTATATACTTTTTTAATATAAGTTAACTTTCTAAAAACTCT
TGCTGTCTTTATTCACTTTTCACACTGGTGGGAAAGGGTTGAAGTCGGAGATACGGATATTCACCATAACTTATAGCAATACTTTTTTAT

>40380_40380_2_ITFG1-ZFC3H1_ITFG1_chr16_47252779_ENST00000320640_ZFC3H1_chr12_72041593_ENST00000378743_length(amino acids)=2135AA_BP=484
MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVK
VSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQ
PQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGD
GHMDHLLPGCEDKNCQKSTIYLVRSGMKQWVPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQ
AFLLENVPCNNASCEEARRMFKVYWELTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCS
NDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVM
KESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQ
YNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQV
SSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHP
VPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVP
PKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDE
SVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLE
QDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTL
DTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITE
KVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHI
QDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWR
KPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLD
SALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILS
FQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQ
AVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDK
ARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQV
PYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYW
SNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREV

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Fusion Gene PPI Analysis for ITFG1-ZFC3H1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITFG1-ZFC3H1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITFG1-ZFC3H1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource