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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGA2-MYO18B (FusionGDB2 ID:40410)

Fusion Gene Summary for ITGA2-MYO18B

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA2-MYO18B
Fusion gene ID: 40410
HgeneTgene
Gene symbol

ITGA2

MYO18B

Gene ID

3673

84700

Gene nameintegrin subunit alpha 2myosin XVIIIB
SynonymsBR|CD49B|GPIa|HPA-5|VLA-2|VLAA2KFS4
Cytomap

5q11.2

22q12.1

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-2CD49 antigen-like family member Balpha 2 subunit of VLA-2 receptorcollagen receptorhuman platelet alloantigen system 5integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)platelet antigen Brplatelet glycoprotein GPIaplateletunconventional myosin-XVIIIbmyosin 18B
Modification date2020031420200313
UniProtAcc

P17301

Q8IUG5

Ensembl transtripts involved in fusion geneENST00000296585, ENST00000536204, 
ENST00000335473, ENST00000407587, 
ENST00000536101, 
Fusion gene scores* DoF score10 X 7 X 6=42011 X 11 X 9=1089
# samples 1011
** MAII scorelog2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/1089*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA2 [Title/Abstract] AND MYO18B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGA2(52353931)-MYO18B(26388329), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO18B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-P4-A5EB-01AITGA2chr5

52353931

-MYO18Bchr22

26388329

+
ChimerDB4KIRPTCGA-P4-A5EB-01AITGA2chr5

52353931

+MYO18Bchr22

26388329

+
ChimerDB4KIRPTCGA-P4-A5EBITGA2chr5

52353931

+MYO18Bchr22

26388329

+


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Fusion Gene ORF analysis for ITGA2-MYO18B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296585ENST00000536204ITGA2chr5

52353931

+MYO18Bchr22

26388329

+
In-frameENST00000296585ENST00000335473ITGA2chr5

52353931

+MYO18Bchr22

26388329

+
In-frameENST00000296585ENST00000407587ITGA2chr5

52353931

+MYO18Bchr22

26388329

+
In-frameENST00000296585ENST00000536101ITGA2chr5

52353931

+MYO18Bchr22

26388329

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296585ITGA2chr552353931+ENST00000536101MYO18Bchr2226388329+295213161012863920
ENST00000296585ITGA2chr552353931+ENST00000335473MYO18Bchr2226388329+347513161012863920
ENST00000296585ITGA2chr552353931+ENST00000407587MYO18Bchr2226388329+307813161012863920

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296585ENST00000536101ITGA2chr552353931+MYO18Bchr2226388329+0.0012647630.99873525
ENST00000296585ENST00000335473ITGA2chr552353931+MYO18Bchr2226388329+0.0013131220.99868685
ENST00000296585ENST00000407587ITGA2chr552353931+MYO18Bchr2226388329+0.0013295330.99867046

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Fusion Genomic Features for ITGA2-MYO18B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGA2chr552353931+MYO18Bchr2226388328+0.0010996040.9989004
ITGA2chr552353931+MYO18Bchr2226388328+0.0010996040.9989004
ITGA2chr552353931+MYO18Bchr2226388328+0.0010996040.9989004
ITGA2chr552353931+MYO18Bchr2226388328+0.0010996040.9989004

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ITGA2-MYO18B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:52353931/chr22:26388329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA2

P17301

MYO18B

Q8IUG5

FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.FUNCTION: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030188_3653911182.0DomainVWFA
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030101_1613911182.0RepeatFG-GAP 2
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+103034_923911182.0RepeatFG-GAP 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030499_5073911182.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030563_5713911182.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030627_6353911182.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+10301157_11613911182.0MotifNote=GFFKR motif
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030366_4203911182.0RepeatFG-GAP 3
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030423_4753911182.0RepeatFG-GAP 4
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030477_5393911182.0RepeatFG-GAP 5
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030540_5983911182.0RepeatFG-GAP 6
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+1030602_6643911182.0RepeatFG-GAP 7
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+10301155_11813911182.0Topological domainCytoplasmic
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+103030_11323911182.0Topological domainExtracellular
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+10301133_11543911182.0TransmembraneHelical


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Fusion Gene Sequence for ITGA2-MYO18B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40410_40410_1_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000335473_length(transcript)=3475nt_BP=1316nt
TTTTCCCTGCTCTCACCGGGCGGGGGAGAGAAGCCCTCTGGACAGCTTCTAGAGTGTGCAGGTTCTCGTATCCCTCGGCCAAGGGTATCC
TCTGCAAACCTCTGCAAACCCAGCGCAACTACGGTCCCCCGGTCAGACCCAGGATGGGGCCAGAACGGACAGGGGCCGCGCCGCTGCCGC
TGCTGCTGGTGTTAGCGCTCAGTCAAGGCATTTTAAATTGTTGTTTGGCCTACAATGTTGGTCTCCCAGAAGCAAAAATATTTTCCGGTC
CTTCAAGTGAACAGTTTGGCTATGCAGTGCAGCAGTTTATAAATCCAAAAGGCAACTGGTTACTGGTTGGTTCACCCTGGAGTGGCTTTC
CTGAGAACCGAATGGGAGATGTGTATAAATGTCCTGTTGACCTATCCACTGCCACATGTGAAAAACTAAATTTGCAAACTTCAACAAGCA
TTCCAAATGTTACTGAGATGAAAACCAACATGAGCCTCGGCTTGATCCTCACCAGGAACATGGGAACTGGAGGTTTTCTCACATGTGGTC
CTCTGTGGGCACAGCAATGTGGGAATCAGTATTACACAACGGGTGTGTGTTCTGACATCAGTCCTGATTTTCAGCTCTCAGCCAGCTTCT
CACCTGCAACTCAGCCCTGCCCTTCCCTCATAGATGTTGTGGTTGTGTGTGATGAATCAAATAGTATTTATCCTTGGGATGCAGTAAAGA
ATTTTTTGGAAAAATTTGTACAAGGCCTGGATATAGGCCCCACAAAGACACAGGTGGGGTTAATTCAGTATGCCAATAATCCAAGAGTTG
TGTTTAACTTGAACACATATAAAACCAAAGAAGAAATGATTGTAGCAACATCCCAGACATCCCAATATGGTGGGGACCTCACAAACACAT
TCGGAGCAATTCAATATGCAAGAAAATATGCTTATTCAGCAGCTTCTGGTGGGCGACGAAGTGCTACGAAAGTAATGGTAGTTGTAACTG
ACGGTGAATCACATGATGGTTCAATGTTGAAAGCTGTGATTGATCAATGCAACCATGACAATATACTGAGGTTTGGCATAGCAGTTCTTG
GGTACTTAAACAGAAACGCCCTTGATACTAAAAATTTAATAAAAGAAATAAAAGCAATCGCTAGTATTCCAACAGAAAGATACTTTTTCA
ATGTGTCTGATGAAGCAGCTCTACTAGAAAAGGCTGGGACATTAGGAGAACAAATTTTCAGCATTGAAGGTACTGTTCAAGGAGGAGACA
ACTTTCAGATGGAAATGTCACAAGTGGGATTCAGTGCAGATTACTCTTCTCAAAATGAGAAGTACGTGGAGGAACTTGCAGCAGTGAGGC
AAACCCTCCAGACAGACCTGGAGACATCCATTCGGCGGATTGCCGACCTGCAGGCTGCCTTGGAAGAAGTGGCATCCAGTGACAGTGATA
CTGAGAGTGTCCAGACGGCAGTGGATTGTGGCAGCAGCGGCCGAAAAGAGATGGATAACGTCTCCATCCTCAGCTCCCAGCCAGAGGGCA
GCCTGCAGTCCTGGTTGAGCTGTACTCTGTCCCTGGCCACAGATACTATGAGGACTCCTTCTCGACAGTCAGCCACCAGCAGCCGCATCC
TCAGCCCCAGGATAAACGAAGAGGCTGGGGACACTGAGAGGACCCAGTCGGCATTGGCACTGAGCAGAGCCCGGTCCACCAATGTCCACA
GCAAGACCTCAGGAGACAAGCCTGTTTCTCCCCACTTTGTCCGCCGGCAAAAGTACTGTCATTTTGGGGACGGCGAAGTGCTTGCCGTCC
AGAGAAAGTCCACAGAGAGATTAGAACCTGCTTCCTCTCCCCTGGCTTCTCGGAGTACAAATACATCCCCGCTGTCGAGGGAAAAGCTGC
CCAGTCCTTCAGCGGCCCTCTCGGAGTTCGTGGAAGGGCTCCGGAGGAAGAGAGCCCAGAGAGGCCAGGGGTCCACGCTGGGCCTAGAGG
ACTGGCCCACTCTCCCCATTTACCAGACGACTGGGGCCTCCACACTAAGGAGGGGCAGGGCTGGCAGTGACGAGGGAAACCTCTCGCTGA
GGGTTGGGGCAAAGTCACCCCTGGAAATCGAAGGGGCCGCTGGTGGTCTCTTGAGGTCCACCAGCCTCAAATGCATCTCTTCAGACGGTG
TTGGGGGCACAACCCTACTCCCCGAAAAGTCGAAAACCCAATTCAGTTCCTGCGAGTCCCTCTTAGAATCCAGACCGAGCATGGGGAGAA
AACTGAGCTCTCCGACCACACCCAGGGACATGCTGTTGTCGCCCACACTGCGTCCTCGGAGGCGGTGTCTGGAGTCCTCTGTGGACGATG
CGGGCTGTCCAGACCTTGGAAAGGAGCCGCTTGTTTTCCAGAACCGCCAGTTTGCCCACCTGATGGAGGAACCTCTAGGCAGTGACCCAT
TCAGCTGGAAACTCCCAAGCCTCGACTACGAACGCAAGACCAAAGTGGACTTCGATGACTTCCTCCCAGCTATCCGGAAGCCCCAGACAC
CTACCTCCTTGGCTGGATCAGCCAAAGGTGGGCAAGACGGTTCACAGCGTTCAAGCATCCACTTTGAAACGGAAGAGGCTAACCGTTCCT
TTCTCTCGGGGATCAAGACCATTTTGAAGAAGAGCCCGGAGCCCAAGGAGGATCCCGCTCACCTGTCTGACTCGTCCTCATCCTCCGGCT
CCATCGTGTCCTTCAAAAGTGCTGACAGCATCAAAAGTCGACCAGGAATCCCACGACTTGCGGGTGACGGTGGCGAGCGAACGTCCCCCG
AGCGGAGAGAGCCAGGGACGGGGAGGAAAGACGACGATGTTGCGAGCATAATGAAGAAATACCTCCAGAAGTAGGAACCAGTTCAGCCTC
CTTGAAGCTGCCCTTGAAGACTTCCCGACTCTACAATAACTTGGAGACAGAGAGACTGGCCAGGCCTCCCCGGTGGCCAGAGCCAGCCAG
CATGGCCACCCTCAAGAGGCGAGATGAGCCCACAGAGGCATATCCTGCGGGGATGCTGGGCTCCCAGTGTGGTTGGCCTGAACAAAATAA
AGTGTTGACTCCTGGGCATCTGTGCCTTCTCTATGGCCTTGCTACCTGGGATTCCAGAGAGTTGATGGGGTGCAGATAGGGGTAGGACTG
TTAGAATAGAACCAACCCAAACTGTGTGTAGTTTGGGGTGTATACTTCTATTTCTCTTCCTACATGTCTACATGCCATGACCTTCCTCCT
CCTCTTCACTTGGCCAGTTTCAGCTCACTTCCTCCAGGAAGTCTTTCCTGATATATCAAACTGAAACAAATGCTCCTCCTCCATGCTCCC
TTAATCCCCATGCTTGTCGATTATATTCCTTTGCCAATTCATTTCTCTATCCTGTGTATGTATAAGTGTGTACAAGCATTCAAGAAACTG

>40410_40410_1_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000335473_length(amino acids)=920AA_BP=405
MQTQRNYGPPVRPRMGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENR
MGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPAT
QPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAI
QYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSD
EAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESV
QTAVDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTS
GDKPVSPHFVRRQKYCHFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQGSTLGLEDWPT
LPIYQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLLRSTSLKCISSDGVGGTTLLPEKSKTQFSSCESLLESRPSMGRKLSS
PTTPRDMLLSPTLRPRRRCLESSVDDAGCPDLGKEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVDFDDFLPAIRKPQTPTSL
AGSAKGGQDGSQRSSIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLSDSSSSSGSIVSFKSADSIKSRPGIPRLAGDGGERTSPERRE

--------------------------------------------------------------
>40410_40410_2_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000407587_length(transcript)=3078nt_BP=1316nt
TTTTCCCTGCTCTCACCGGGCGGGGGAGAGAAGCCCTCTGGACAGCTTCTAGAGTGTGCAGGTTCTCGTATCCCTCGGCCAAGGGTATCC
TCTGCAAACCTCTGCAAACCCAGCGCAACTACGGTCCCCCGGTCAGACCCAGGATGGGGCCAGAACGGACAGGGGCCGCGCCGCTGCCGC
TGCTGCTGGTGTTAGCGCTCAGTCAAGGCATTTTAAATTGTTGTTTGGCCTACAATGTTGGTCTCCCAGAAGCAAAAATATTTTCCGGTC
CTTCAAGTGAACAGTTTGGCTATGCAGTGCAGCAGTTTATAAATCCAAAAGGCAACTGGTTACTGGTTGGTTCACCCTGGAGTGGCTTTC
CTGAGAACCGAATGGGAGATGTGTATAAATGTCCTGTTGACCTATCCACTGCCACATGTGAAAAACTAAATTTGCAAACTTCAACAAGCA
TTCCAAATGTTACTGAGATGAAAACCAACATGAGCCTCGGCTTGATCCTCACCAGGAACATGGGAACTGGAGGTTTTCTCACATGTGGTC
CTCTGTGGGCACAGCAATGTGGGAATCAGTATTACACAACGGGTGTGTGTTCTGACATCAGTCCTGATTTTCAGCTCTCAGCCAGCTTCT
CACCTGCAACTCAGCCCTGCCCTTCCCTCATAGATGTTGTGGTTGTGTGTGATGAATCAAATAGTATTTATCCTTGGGATGCAGTAAAGA
ATTTTTTGGAAAAATTTGTACAAGGCCTGGATATAGGCCCCACAAAGACACAGGTGGGGTTAATTCAGTATGCCAATAATCCAAGAGTTG
TGTTTAACTTGAACACATATAAAACCAAAGAAGAAATGATTGTAGCAACATCCCAGACATCCCAATATGGTGGGGACCTCACAAACACAT
TCGGAGCAATTCAATATGCAAGAAAATATGCTTATTCAGCAGCTTCTGGTGGGCGACGAAGTGCTACGAAAGTAATGGTAGTTGTAACTG
ACGGTGAATCACATGATGGTTCAATGTTGAAAGCTGTGATTGATCAATGCAACCATGACAATATACTGAGGTTTGGCATAGCAGTTCTTG
GGTACTTAAACAGAAACGCCCTTGATACTAAAAATTTAATAAAAGAAATAAAAGCAATCGCTAGTATTCCAACAGAAAGATACTTTTTCA
ATGTGTCTGATGAAGCAGCTCTACTAGAAAAGGCTGGGACATTAGGAGAACAAATTTTCAGCATTGAAGGTACTGTTCAAGGAGGAGACA
ACTTTCAGATGGAAATGTCACAAGTGGGATTCAGTGCAGATTACTCTTCTCAAAATGAGAAGTACGTGGAGGAACTTGCAGCAGTGAGGC
AAACCCTCCAGACAGACCTGGAGACATCCATTCGGCGGATTGCCGACCTGCAGGCTGCCTTGGAAGAAGTGGCATCCAGTGACAGTGATA
CTGAGAGTGTCCAGACGGCAGTGGATTGTGGCAGCAGCGGCCGAAAAGAGATGGATAACGTCTCCATCCTCAGCTCCCAGCCAGAGGGCA
GCCTGCAGTCCTGGTTGAGCTGTACTCTGTCCCTGGCCACAGATACTATGAGGACTCCTTCTCGACAGTCAGCCACCAGCAGCCGCATCC
TCAGCCCCAGGATAAACGAAGAGGCTGGGGACACTGAGAGGACCCAGTCGGCATTGGCACTGAGCAGAGCCCGGTCCACCAATGTCCACA
GCAAGACCTCAGGAGACAAGCCTGTTTCTCCCCACTTTGTCCGCCGGCAAAAGTACTGTCATTTTGGGGACGGCGAAGTGCTTGCCGTCC
AGAGAAAGTCCACAGAGAGATTAGAACCTGCTTCCTCTCCCCTGGCTTCTCGGAGTACAAATACATCCCCGCTGTCGAGGGAAAAGCTGC
CCAGTCCTTCAGCGGCCCTCTCGGAGTTCGTGGAAGGGCTCCGGAGGAAGAGAGCCCAGAGAGGCCAGGGGTCCACGCTGGGCCTAGAGG
ACTGGCCCACTCTCCCCATTTACCAGACGACTGGGGCCTCCACACTAAGGAGGGGCAGGGCTGGCAGTGACGAGGGAAACCTCTCGCTGA
GGGTTGGGGCAAAGTCACCCCTGGAAATCGAAGGGGCCGCTGGTGGTCTCTTGAGGTCCACCAGCCTCAAATGCATCTCTTCAGACGGTG
TTGGGGGCACAACCCTACTCCCCGAAAAGTCGAAAACCCAATTCAGTTCCTGCGAGTCCCTCTTAGAATCCAGACCGAGCATGGGGAGAA
AACTGAGCTCTCCGACCACACCCAGGGACATGCTGTTGTCGCCCACACTGCGTCCTCGGAGGCGGTGTCTGGAGTCCTCTGTGGACGATG
CGGGCTGTCCAGACCTTGGAAAGGAGCCGCTTGTTTTCCAGAACCGCCAGTTTGCCCACCTGATGGAGGAACCTCTAGGCAGTGACCCAT
TCAGCTGGAAACTCCCAAGCCTCGACTACGAACGCAAGACCAAAGTGGACTTCGATGACTTCCTCCCAGCTATCCGGAAGCCCCAGACAC
CTACCTCCTTGGCTGGATCAGCCAAAGGTGGGCAAGACGGTTCACAGCGTTCAAGCATCCACTTTGAAACGGAAGAGGCTAACCGTTCCT
TTCTCTCGGGGATCAAGACCATTTTGAAGAAGAGCCCGGAGCCCAAGGAGGATCCCGCTCACCTGTCTGACTCGTCCTCATCCTCCGGCT
CCATCGTGTCCTTCAAAAGTGCTGACAGCATCAAAAGTCGACCAGGAATCCCACGACTTGCGGGTGACGGTGGCGAGCGAACGTCCCCCG
AGCGGAGAGAGCCAGGGACGGGGAGGAAAGACGACGATGTTGCGAGCATAATGAAGAAATACCTCCAGAAGTAGGAACCAGTTCAGCCTC
CTTGAAGCTGCCCTTGAAGACTTCCCGACTCTACAATAACTTGGAGACAGAGAGACTGGCCAGGCCTCCCCGGTGGCCAGAGCCAGCCAG
CATGGCCACCCTCAAGAGGCGAGATGAGCCCACAGAGGCATATCCTGCGGGGATGCTGGGCTCCCAGTGTGGTTGGCCTGAACAAAATAA

>40410_40410_2_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000407587_length(amino acids)=920AA_BP=405
MQTQRNYGPPVRPRMGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENR
MGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPAT
QPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAI
QYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSD
EAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESV
QTAVDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTS
GDKPVSPHFVRRQKYCHFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQGSTLGLEDWPT
LPIYQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLLRSTSLKCISSDGVGGTTLLPEKSKTQFSSCESLLESRPSMGRKLSS
PTTPRDMLLSPTLRPRRRCLESSVDDAGCPDLGKEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVDFDDFLPAIRKPQTPTSL
AGSAKGGQDGSQRSSIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLSDSSSSSGSIVSFKSADSIKSRPGIPRLAGDGGERTSPERRE

--------------------------------------------------------------
>40410_40410_3_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000536101_length(transcript)=2952nt_BP=1316nt
TTTTCCCTGCTCTCACCGGGCGGGGGAGAGAAGCCCTCTGGACAGCTTCTAGAGTGTGCAGGTTCTCGTATCCCTCGGCCAAGGGTATCC
TCTGCAAACCTCTGCAAACCCAGCGCAACTACGGTCCCCCGGTCAGACCCAGGATGGGGCCAGAACGGACAGGGGCCGCGCCGCTGCCGC
TGCTGCTGGTGTTAGCGCTCAGTCAAGGCATTTTAAATTGTTGTTTGGCCTACAATGTTGGTCTCCCAGAAGCAAAAATATTTTCCGGTC
CTTCAAGTGAACAGTTTGGCTATGCAGTGCAGCAGTTTATAAATCCAAAAGGCAACTGGTTACTGGTTGGTTCACCCTGGAGTGGCTTTC
CTGAGAACCGAATGGGAGATGTGTATAAATGTCCTGTTGACCTATCCACTGCCACATGTGAAAAACTAAATTTGCAAACTTCAACAAGCA
TTCCAAATGTTACTGAGATGAAAACCAACATGAGCCTCGGCTTGATCCTCACCAGGAACATGGGAACTGGAGGTTTTCTCACATGTGGTC
CTCTGTGGGCACAGCAATGTGGGAATCAGTATTACACAACGGGTGTGTGTTCTGACATCAGTCCTGATTTTCAGCTCTCAGCCAGCTTCT
CACCTGCAACTCAGCCCTGCCCTTCCCTCATAGATGTTGTGGTTGTGTGTGATGAATCAAATAGTATTTATCCTTGGGATGCAGTAAAGA
ATTTTTTGGAAAAATTTGTACAAGGCCTGGATATAGGCCCCACAAAGACACAGGTGGGGTTAATTCAGTATGCCAATAATCCAAGAGTTG
TGTTTAACTTGAACACATATAAAACCAAAGAAGAAATGATTGTAGCAACATCCCAGACATCCCAATATGGTGGGGACCTCACAAACACAT
TCGGAGCAATTCAATATGCAAGAAAATATGCTTATTCAGCAGCTTCTGGTGGGCGACGAAGTGCTACGAAAGTAATGGTAGTTGTAACTG
ACGGTGAATCACATGATGGTTCAATGTTGAAAGCTGTGATTGATCAATGCAACCATGACAATATACTGAGGTTTGGCATAGCAGTTCTTG
GGTACTTAAACAGAAACGCCCTTGATACTAAAAATTTAATAAAAGAAATAAAAGCAATCGCTAGTATTCCAACAGAAAGATACTTTTTCA
ATGTGTCTGATGAAGCAGCTCTACTAGAAAAGGCTGGGACATTAGGAGAACAAATTTTCAGCATTGAAGGTACTGTTCAAGGAGGAGACA
ACTTTCAGATGGAAATGTCACAAGTGGGATTCAGTGCAGATTACTCTTCTCAAAATGAGAAGTACGTGGAGGAACTTGCAGCAGTGAGGC
AAACCCTCCAGACAGACCTGGAGACATCCATTCGGCGGATTGCCGACCTGCAGGCTGCCTTGGAAGAAGTGGCATCCAGTGACAGTGATA
CTGAGAGTGTCCAGACGGCAGTGGATTGTGGCAGCAGCGGCCGAAAAGAGATGGATAACGTCTCCATCCTCAGCTCCCAGCCAGAGGGCA
GCCTGCAGTCCTGGTTGAGCTGTACTCTGTCCCTGGCCACAGATACTATGAGGACTCCTTCTCGACAGTCAGCCACCAGCAGCCGCATCC
TCAGCCCCAGGATAAACGAAGAGGCTGGGGACACTGAGAGGACCCAGTCGGCATTGGCACTGAGCAGAGCCCGGTCCACCAATGTCCACA
GCAAGACCTCAGGAGACAAGCCTGTTTCTCCCCACTTTGTCCGCCGGCAAAAGTACTGTCATTTTGGGGACGGCGAAGTGCTTGCCGTCC
AGAGAAAGTCCACAGAGAGATTAGAACCTGCTTCCTCTCCCCTGGCTTCTCGGAGTACAAATACATCCCCGCTGTCGAGGGAAAAGCTGC
CCAGTCCTTCAGCGGCCCTCTCGGAGTTCGTGGAAGGGCTCCGGAGGAAGAGAGCCCAGAGAGGCCAGGGGTCCACGCTGGGCCTAGAGG
ACTGGCCCACTCTCCCCATTTACCAGACGACTGGGGCCTCCACACTAAGGAGGGGCAGGGCTGGCAGTGACGAGGGAAACCTCTCGCTGA
GGGTTGGGGCAAAGTCACCCCTGGAAATCGAAGGGGCCGCTGGTGGTCTCTTGAGGTCCACCAGCCTCAAATGCATCTCTTCAGACGGTG
TTGGGGGCACAACCCTACTCCCCGAAAAGTCGAAAACCCAATTCAGTTCCTGCGAGTCCCTCTTAGAATCCAGACCGAGCATGGGGAGAA
AACTGAGCTCTCCGACCACACCCAGGGACATGCTGTTGTCGCCCACACTGCGTCCTCGGAGGCGGTGTCTGGAGTCCTCTGTGGACGATG
CGGGCTGTCCAGACCTTGGAAAGGAGCCGCTTGTTTTCCAGAACCGCCAGTTTGCCCACCTGATGGAGGAACCTCTAGGCAGTGACCCAT
TCAGCTGGAAACTCCCAAGCCTCGACTACGAACGCAAGACCAAAGTGGACTTCGATGACTTCCTCCCAGCTATCCGGAAGCCCCAGACAC
CTACCTCCTTGGCTGGATCAGCCAAAGGTGGGCAAGACGGTTCACAGCGTTCAAGCATCCACTTTGAAACGGAAGAGGCTAACCGTTCCT
TTCTCTCGGGGATCAAGACCATTTTGAAGAAGAGCCCGGAGCCCAAGGAGGATCCCGCTCACCTGTCTGACTCGTCCTCATCCTCCGGCT
CCATCGTGTCCTTCAAAAGTGCTGACAGCATCAAAAGTCGACCAGGAATCCCACGACTTGCGGGTGACGGTGGCGAGCGAACGTCCCCCG
AGCGGAGAGAGCCAGGGACGGGGAGGAAAGACGACGATGTTGCGAGCATAATGAAGAAATACCTCCAGAAGTAGGAACCAGTTCAGGTAA

>40410_40410_3_ITGA2-MYO18B_ITGA2_chr5_52353931_ENST00000296585_MYO18B_chr22_26388329_ENST00000536101_length(amino acids)=920AA_BP=405
MQTQRNYGPPVRPRMGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENR
MGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPAT
QPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAI
QYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSD
EAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESV
QTAVDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTS
GDKPVSPHFVRRQKYCHFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQGSTLGLEDWPT
LPIYQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLLRSTSLKCISSDGVGGTTLLPEKSKTQFSSCESLLESRPSMGRKLSS
PTTPRDMLLSPTLRPRRRCLESSVDDAGCPDLGKEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVDFDDFLPAIRKPQTPTSL
AGSAKGGQDGSQRSSIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLSDSSSSSGSIVSFKSADSIKSRPGIPRLAGDGGERTSPERRE

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Fusion Gene PPI Analysis for ITGA2-MYO18B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneITGA2chr5:52353931chr22:26388329ENST00000296585+10301155_1161391.01182.0HPS5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGA2-MYO18B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGA2-MYO18B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource