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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGA9-SMOC2 (FusionGDB2 ID:40473)

Fusion Gene Summary for ITGA9-SMOC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA9-SMOC2
Fusion gene ID: 40473
HgeneTgene
Gene symbol

ITGA9

SMOC2

Gene ID

3680

64094

Gene nameintegrin subunit alpha 9SPARC related modular calcium binding 2
SynonymsALPHA-RLC|ITGA4L|RLCDTDP1|MST117|MSTP117|MSTP140|SMAP2|bA270C4A.1|bA37D8.1|dJ421D16.1
Cytomap

3p22.2

6q27

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-9integrin alpha-RLCSPARC-related modular calcium-binding protein 2SMAP-2SMOC-2secreted modular calcium-binding protein 2smooth muscle associated protein 2thyroglobulin type-1 repeat containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264741, ENST00000422441, 
ENST00000477998, ENST00000354536, 
ENST00000356284, 
Fusion gene scores* DoF score12 X 8 X 10=96010 X 8 X 7=560
# samples 1310
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA9 [Title/Abstract] AND SMOC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGA9(37584076)-SMOC2(168910594), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMOC2

GO:0010595

positive regulation of endothelial cell migration

16774925

TgeneSMOC2

GO:0035470

positive regulation of vascular wound healing

16774925

TgeneSMOC2

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

16774925

TgeneSMOC2

GO:0045766

positive regulation of angiogenesis

16774925

TgeneSMOC2

GO:0045931

positive regulation of mitotic cell cycle

16774925

TgeneSMOC2

GO:1900748

positive regulation of vascular endothelial growth factor signaling pathway

16774925

TgeneSMOC2

GO:2000573

positive regulation of DNA biosynthetic process

16774925


check buttonFusion gene breakpoints across ITGA9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMOC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer145NITGA9chr3

37584076

+SMOC2chr6

168910594

+


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Fusion Gene ORF analysis for ITGA9-SMOC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264741ENST00000477998ITGA9chr3

37584076

+SMOC2chr6

168910594

+
5CDS-intronENST00000422441ENST00000477998ITGA9chr3

37584076

+SMOC2chr6

168910594

+
In-frameENST00000264741ENST00000354536ITGA9chr3

37584076

+SMOC2chr6

168910594

+
In-frameENST00000264741ENST00000356284ITGA9chr3

37584076

+SMOC2chr6

168910594

+
In-frameENST00000422441ENST00000354536ITGA9chr3

37584076

+SMOC2chr6

168910594

+
In-frameENST00000422441ENST00000356284ITGA9chr3

37584076

+SMOC2chr6

168910594

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264741ITGA9chr337584076+ENST00000356284SMOC2chr6168910594+475819452503201983
ENST00000264741ITGA9chr337584076+ENST00000354536SMOC2chr6168910594+479119452503234994
ENST00000422441ITGA9chr337584076+ENST00000356284SMOC2chr6168910594+476219492543205983
ENST00000422441ITGA9chr337584076+ENST00000354536SMOC2chr6168910594+479519492543238994

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264741ENST00000356284ITGA9chr337584076+SMOC2chr6168910594+0.0004470070.999553
ENST00000264741ENST00000354536ITGA9chr337584076+SMOC2chr6168910594+0.0004389830.999561
ENST00000422441ENST00000356284ITGA9chr337584076+SMOC2chr6168910594+0.0004499140.99955004
ENST00000422441ENST00000354536ITGA9chr337584076+SMOC2chr6168910594+0.0004413880.9995586

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Fusion Genomic Features for ITGA9-SMOC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGA9chr337584076+SMOC2chr6168910594+1.23E-070.9999999
ITGA9chr337584076+SMOC2chr6168910594+1.23E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ITGA9-SMOC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:37584076/chr6:168910594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528312_3205631036.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528373_3815631036.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528435_4435631036.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528111_1745631036.0RepeatFG-GAP 2
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528182_2325631036.0RepeatFG-GAP 3
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528233_2895631036.0RepeatFG-GAP 4
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528290_3495631036.0RepeatFG-GAP 5
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528351_4085631036.0RepeatFG-GAP 6
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+152835_965631036.0RepeatFG-GAP 1
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528411_4745631036.0RepeatFG-GAP 7
TgeneSMOC2chr3:37584076chr6:168910594ENST00000354536013360_37128458.0Calcium binding1
TgeneSMOC2chr3:37584076chr6:168910594ENST00000354536013397_40828458.0Calcium binding2
TgeneSMOC2chr3:37584076chr6:168910594ENST00000356284013360_37128447.0Calcium binding1
TgeneSMOC2chr3:37584076chr6:168910594ENST00000356284013397_40828447.0Calcium binding2
TgeneSMOC2chr3:37584076chr6:168910594ENST00000354536013213_28128458.0DomainThyroglobulin type-1 2
TgeneSMOC2chr3:37584076chr6:168910594ENST00000354536013347_38228458.0DomainEF-hand 1
TgeneSMOC2chr3:37584076chr6:168910594ENST0000035453601334_8628458.0DomainKazal-like
TgeneSMOC2chr3:37584076chr6:168910594ENST00000354536013384_41928458.0DomainEF-hand 2
TgeneSMOC2chr3:37584076chr6:168910594ENST0000035453601387_15328458.0DomainThyroglobulin type-1 1
TgeneSMOC2chr3:37584076chr6:168910594ENST00000356284013213_28128447.0DomainThyroglobulin type-1 2
TgeneSMOC2chr3:37584076chr6:168910594ENST00000356284013347_38228447.0DomainEF-hand 1
TgeneSMOC2chr3:37584076chr6:168910594ENST0000035628401334_8628447.0DomainKazal-like
TgeneSMOC2chr3:37584076chr6:168910594ENST00000356284013384_41928447.0DomainEF-hand 2
TgeneSMOC2chr3:37584076chr6:168910594ENST0000035628401387_15328447.0DomainThyroglobulin type-1 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+15281005_10095631036.0MotifNote=GFFKR motif
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+15281003_10355631036.0Topological domainCytoplasmic
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+152830_9815631036.0Topological domainExtracellular
HgeneITGA9chr3:37584076chr6:168910594ENST00000264741+1528982_10025631036.0TransmembraneHelical


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Fusion Gene Sequence for ITGA9-SMOC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40473_40473_1_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000264741_SMOC2_chr6_168910594_ENST00000354536_length(transcript)=4791nt_BP=1945nt
CCGGCCCGGGACCCGCTCGCGCAGACTTCTCGGGCGGACTGAGGACGCCGCCGCTCGGGGCCGCCCCTGTGCTCGCCTTCAGCGCCCGCT
CAGCCCGCCGTCCGCGCCCCGGTGGCGGGCCCGACGCCCGCATTCCGCCCGTGTCCAGGCGCAGAGCTCCCGCCCCGGGGAGCTTCCTGG
CCGTCGGCGGGCCCCGCGGCCCGCGCGCTCGGCGCCCTGCTCGCCGGGCAGAGGGGAAGGCGGCGGCCGGCTGGGGATGGGCGGCCCGGC
TGCGCCGAGGGGCGCCGGGAGGCTCCGCGCGCTGCTGCTGGCGCTGGTGGTCGCGGGGATCCCCGCGGGCGCCTACAACCTCGACCCGCA
GCGCCCCGTGCACTTCCAGGGCCCCGCTGACTCGTTCTTCGGCTACGCAGTTCTGGAGCATTTCCACGACAACACGCGCTGGGTCCTTGT
GGGCGCACCAAAGGCAGATTCCAAATACAGCCCTTCAGTGAAGTCTCCTGGGGCTGTGTTTAAGTGCCGTGTTCACACCAACCCTGACCG
GAGATGCACCGAACTGGACATGGCTCGAGGGAAGAATCGGGGCACGTCCTGCGGAAAGACCTGCCGGGAAGACCGCGATGATGAGTGGAT
GGGGGTGAGCCTGGCCCGACAGCCCAAGGCTGATGGCCGTGTGTTGGCCTGTGCTCATCGCTGGAAGAACATCTACTATGAAGCCGACCA
CATCCTACCCCATGGCTTCTGCTACATCATCCCCTCCAACCTCCAGGCCAAAGGCAGGACGCTGATCCCTTGCTATGAAGAGTATAAGAA
GAAGTACGGAGAGGAACACGGCTCCTGCCAGGCTGGGATAGCGGGCTTCTTCACCGAGGAGCTGGTGGTGATGGGTGCTCCAGGGTCATT
TTATTGGGCTGGAACCATCAAAGTGCTGAACCTTACGGACAACACCTATTTAAAACTGAACGACGAAGTGATCATGAACAGGCGGTACAC
CTACCTGGGCTACGCAGTGACCGCTGGCCACTTCTCTCACCCGTCCACCATTGATGTGGTAGGAGGTGCCCCACAGGACAAAGGCATCGG
CAAGGTTTATATTTTCAGAGCTGACCGAAGATCAGGCACCTTAATTAAGATCTTTCAAGCATCAGGTAAAAAGATGGGCTCTTACTTCGG
CTCCTCCTTGTGCGCAGTTGACCTGAATGGGGACGGCCTCTCTGACCTGCTGGTGGGGGCCCCCATGTTTTCTGAGATCAGGGATGAGGG
ACAGGTCACTGTCTACATCAACAGAGGAAATGGAGCCCTCGAGGAGCAGCTGGCTCTGACTGGGGATGGTGCCTACAATGCGCACTTTGG
AGAGAGCATTGCCAGCCTGGACGATCTGGACAATGATGGGTTCCCAGATGTGGCCATTGGTGCACCCAAGGAGGATGACTTCGCAGGGGC
GGTCTATATCTATCATGGTGATGCCGGTGGGATAGTCCCTCAGTACTCAATGAAACTGTCTGGGCAGAAGATAAATCCAGTGCTCCGGAT
GTTTGGTCAGTCCATATCGGGAGGCATTGATATGGATGGAAATGGCTATCCTGATGTCACTGTTGGAGCCTTCATGTCCGACAGCGTGGT
TCTTCTCAGAGCAAGGCCTGTCATTACGGTGGATGTCTCCATCTTCCTCCCGGGCTCCATCAACATCACAGCGCCTCAGTGTCACGACGG
ACAGCAGCCTGTGAACTGCCTGAACGTCACCACCTGCTTCAGCTTCCATGGCAAACACGTTCCAGGAGAGATTGGCCTGAATTATGTTCT
GATGGCTGACGTGGCCAAAAAGGAGAAGGGCCAGATGCCCAGGGTCTACTTTGTGCTGCTGGGAGAGACCATGGGTCAGGTCACAGAGAA
GCTGCAGCTGACTTACATGGAGGAGACGTGTCGTCACTATGTGGCCCATGTGAAGTTTTTGAGAGTGGATCAAGATAAAGACAAGGATTG
TAGCTTGGACTGTGCGGGTTCGCCCCAGAAACCTCTCTGCGCATCTGACGGAAGGACCTTCCTTTCCCGTTGTGAATTTCAACGTGCCAA
GTGCAAAGATCCCCAGCTAGAGATTGCATATCGAGGAAACTGCAAAGACGTGTCCAGGTGTGTGGCCGAAAGGAAGTATACCCAGGAGCA
AGCCCGGAAGGAGTTTCAGCAAGTGTTCATTCCTGAGTGCAATGACGACGGCACCTACAGTCAGGTCCAGTGTCACAGCTACACGGGATA
CTGCTGGTGCGTCACGCCCAACGGGAGGCCCATCAGCGGCACTGCCGTGGCCCACAAGACGCCCCGGTGCCCGGGTTCCGTAAATGAAAA
GTTACCCCAACGCGAAGGCACAGGAAAAACAGTCTCCTTGCAAATCTTTTCCGTTCTGAATTCAGATGATGCCGCAGCTCCAGCGTTGGA
GACTCAGCCTCAAGGAGATGAAGAAGATATTGCATCACGTTACCCTACCCTTTGGACTGAACAGGTTAAAAGTCGGCAGAACAAAACCAA
TAAGAATTCAGTGTCATCCTGTGACCAAGAGCACCAGTCTGCCCTGGAGGAAGCCAAGCAGCCCAAGAACGACAATGTGGTGATCCCTGA
GTGTGCGCACGGCGGCCTCTACAAGCCAGTGCAGTGCCACCCCTCCACGGGGTACTGCTGGTGCGTCCTGGTGGACACGGGGCGCCCCAT
TCCCGGCACATCCACAAGGTACGAGCAGCCGAAATGTGACAACACGGCCAGGGCCCACCCAGCCAAAGCCCGGGACCTGTACAAGGGCCG
CCAGCTACAAGGTTGTCCGGGTGCCAAAAAGCATGAGTTTCTGACCAGCGTTCTGGACGCGCTGTCCACGGACATGGTCCACGCCGCCTC
CGACCCCTCCTCCTCGTCAGGCAGGCTCTCAGAACCCGACCCCAGCCATACCCTAGAGGAGCGGGTGGTGCACTGGTACTTCAAACTACT
GGATAAAAACTCCAGTGGAGACATCGGCAAAAAGGAAATCAAACCCTTCAAGAGGTTCCTTCGCAAAAAATCAAAGCCCAAAAAATGTGT
GAAGAAGTTTGTTGAATACTGTGACGTGAATAATGACAAATCCATCTCCGTACAAGAACTGATGGGCTGCCTGGGCGTGGCGAAAGAGGA
CGGCAAAGCGGACACCAAGAAACGCCACACCCCCAGAGGTCATGCTGAAAGTACGTCTAATAGACAGCCAAGGAAACAAGGATAAATGGC
TCATACCCCGAAGGCAGTTCCTAGACACATGGGAAATTTCCCTCACCAAAGAGCAATTAAGAAAACAAAAACAGAAACACATAGTATTTG
CACTTTGTACTTTAAATGTAAATTCACTTTGTAGAAATGAGCTATTTAAACAGACTGTTTTAATCTGTGAAAATGGAGAGCTGGCTTCAG
AAAATTAATCACATACAATGTATGTGTCCTCTTTTGACCTTGGAAATCTGTATGTGGTGGAGAAGTATTTGAATGCATTTAGGCTTAATT
TCTTCGCCTTCCACATGTTAACAGTAGAGCTCTATGCACTCCGGCTGCAATCGTATGGCTTTCTCTAACCCCTGCAGTCACTTCCAGATG
CCTGTGCTTACAGCATTGTGGAATCATGTTGGAAGCTCCACATGTCCATGGAAGTTTGTGATGTACGGCCGACCCTACAGGCAGTTAACA
TGCATGGGCTGGTTTGTTTCTTGGGATTTTCTGTTAGTTTGTCTTGTTTTGCTTTCCAGAGATCTTGCTCATACAATGAATCACGCAACC
ACTAAAGCTATCCAGTTAAGTGCAGGTAGTTCCCCTGGAGGAAATAATATTTTCAAACTGTCGTTGGTGTGATACTTTGGCTCAAAGGAT
CTTTGCTTTTCCATTTTAAGCTTCTGTTTTGAGTTTTGCCCTGGGGCTTGAATGAGTCCCAGAGAGTCGTTCGGATGGTGGGAGGCTGCC
TAGGAGGCAGTAAATCCAGTCACAGTGCCTGGGAGGGGCCCATCCTTCCAAAATGTAAATCCAGTCGCGGTGTGACCGAGCTGGCTAACA
GGCTTGTCTGCCTGGTTTTCCTCCTACACGTGGACATTATTCTCCTGATCCTCCTACCTGGTCCACCCCAGGGCTACCGGAAGGTAAAAT
CTTCACCTGAACCAATTATGAGCAGTCTCCTTACTGAAGGTACAGCCGGATACGTGGTGCCCCCGGGGCTGGTGTTGGCAGCCGGGGGGA
GGTGCCTGAGGGTCCCCACGGTTCCTTTCTGCTTTTCTGAATGCATCAAGGGTACGAGAACTTGCCAATGGGAAATTCATCCGAGTGGCA
CTGGCAGAGAAGGATAGGAGTGGAATGCCCACACAGTGACCAACAGAACTGGTCTGCGTGCATAACCAGCTGCCACCCTCAGGCCTGGGC
CCCAGAGCTCAGGGCACCCAGTGTCTTAAGGAACCATTTGGAGGACAGTCTGAGAGCAGGAACTTCAAGCTGTGATTCTATCTCGGCTCA
GACTTTTGGTTGGAAAAAGATCTTCATGGCCCCAAATCCCCTGAGACATGCCTTGTAGAATGATTTTGTGATGTTGTGATGCTTGTGGAG
CATCGCGTAAGGCTTCTTGCTTATTTAAACTGTGCAAGGTAAAAATCAAGCCTTTGGAGCCACAGAACCAGCTCAAGTACATGCCAATGT
TGTTTAAGAAACAGTTATGATCCTAAACTTTTTGGATAATCTTTTATATTTCTGACCTTTGAATTTAATCATTGTTCTTAGATTAAAATA

>40473_40473_1_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000264741_SMOC2_chr6_168910594_ENST00000354536_length(amino acids)=994AA_BP=564
MGMGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCR
VHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIP
CYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGA
PQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDG
AYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGA
FMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGET
MGQVTEKLQLTYMEETCRHYVAHVKFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAE
RKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTVSLQIFSVLNSDD
AAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVL
VDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVV
HWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQP

--------------------------------------------------------------
>40473_40473_2_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000264741_SMOC2_chr6_168910594_ENST00000356284_length(transcript)=4758nt_BP=1945nt
CCGGCCCGGGACCCGCTCGCGCAGACTTCTCGGGCGGACTGAGGACGCCGCCGCTCGGGGCCGCCCCTGTGCTCGCCTTCAGCGCCCGCT
CAGCCCGCCGTCCGCGCCCCGGTGGCGGGCCCGACGCCCGCATTCCGCCCGTGTCCAGGCGCAGAGCTCCCGCCCCGGGGAGCTTCCTGG
CCGTCGGCGGGCCCCGCGGCCCGCGCGCTCGGCGCCCTGCTCGCCGGGCAGAGGGGAAGGCGGCGGCCGGCTGGGGATGGGCGGCCCGGC
TGCGCCGAGGGGCGCCGGGAGGCTCCGCGCGCTGCTGCTGGCGCTGGTGGTCGCGGGGATCCCCGCGGGCGCCTACAACCTCGACCCGCA
GCGCCCCGTGCACTTCCAGGGCCCCGCTGACTCGTTCTTCGGCTACGCAGTTCTGGAGCATTTCCACGACAACACGCGCTGGGTCCTTGT
GGGCGCACCAAAGGCAGATTCCAAATACAGCCCTTCAGTGAAGTCTCCTGGGGCTGTGTTTAAGTGCCGTGTTCACACCAACCCTGACCG
GAGATGCACCGAACTGGACATGGCTCGAGGGAAGAATCGGGGCACGTCCTGCGGAAAGACCTGCCGGGAAGACCGCGATGATGAGTGGAT
GGGGGTGAGCCTGGCCCGACAGCCCAAGGCTGATGGCCGTGTGTTGGCCTGTGCTCATCGCTGGAAGAACATCTACTATGAAGCCGACCA
CATCCTACCCCATGGCTTCTGCTACATCATCCCCTCCAACCTCCAGGCCAAAGGCAGGACGCTGATCCCTTGCTATGAAGAGTATAAGAA
GAAGTACGGAGAGGAACACGGCTCCTGCCAGGCTGGGATAGCGGGCTTCTTCACCGAGGAGCTGGTGGTGATGGGTGCTCCAGGGTCATT
TTATTGGGCTGGAACCATCAAAGTGCTGAACCTTACGGACAACACCTATTTAAAACTGAACGACGAAGTGATCATGAACAGGCGGTACAC
CTACCTGGGCTACGCAGTGACCGCTGGCCACTTCTCTCACCCGTCCACCATTGATGTGGTAGGAGGTGCCCCACAGGACAAAGGCATCGG
CAAGGTTTATATTTTCAGAGCTGACCGAAGATCAGGCACCTTAATTAAGATCTTTCAAGCATCAGGTAAAAAGATGGGCTCTTACTTCGG
CTCCTCCTTGTGCGCAGTTGACCTGAATGGGGACGGCCTCTCTGACCTGCTGGTGGGGGCCCCCATGTTTTCTGAGATCAGGGATGAGGG
ACAGGTCACTGTCTACATCAACAGAGGAAATGGAGCCCTCGAGGAGCAGCTGGCTCTGACTGGGGATGGTGCCTACAATGCGCACTTTGG
AGAGAGCATTGCCAGCCTGGACGATCTGGACAATGATGGGTTCCCAGATGTGGCCATTGGTGCACCCAAGGAGGATGACTTCGCAGGGGC
GGTCTATATCTATCATGGTGATGCCGGTGGGATAGTCCCTCAGTACTCAATGAAACTGTCTGGGCAGAAGATAAATCCAGTGCTCCGGAT
GTTTGGTCAGTCCATATCGGGAGGCATTGATATGGATGGAAATGGCTATCCTGATGTCACTGTTGGAGCCTTCATGTCCGACAGCGTGGT
TCTTCTCAGAGCAAGGCCTGTCATTACGGTGGATGTCTCCATCTTCCTCCCGGGCTCCATCAACATCACAGCGCCTCAGTGTCACGACGG
ACAGCAGCCTGTGAACTGCCTGAACGTCACCACCTGCTTCAGCTTCCATGGCAAACACGTTCCAGGAGAGATTGGCCTGAATTATGTTCT
GATGGCTGACGTGGCCAAAAAGGAGAAGGGCCAGATGCCCAGGGTCTACTTTGTGCTGCTGGGAGAGACCATGGGTCAGGTCACAGAGAA
GCTGCAGCTGACTTACATGGAGGAGACGTGTCGTCACTATGTGGCCCATGTGAAGTTTTTGAGAGTGGATCAAGATAAAGACAAGGATTG
TAGCTTGGACTGTGCGGGTTCGCCCCAGAAACCTCTCTGCGCATCTGACGGAAGGACCTTCCTTTCCCGTTGTGAATTTCAACGTGCCAA
GTGCAAAGATCCCCAGCTAGAGATTGCATATCGAGGAAACTGCAAAGACGTGTCCAGGTGTGTGGCCGAAAGGAAGTATACCCAGGAGCA
AGCCCGGAAGGAGTTTCAGCAAGTGTTCATTCCTGAGTGCAATGACGACGGCACCTACAGTCAGGTCCAGTGTCACAGCTACACGGGATA
CTGCTGGTGCGTCACGCCCAACGGGAGGCCCATCAGCGGCACTGCCGTGGCCCACAAGACGCCCCGGTGCCCGGGTTCCGTAAATGAAAA
GTTACCCCAACGCGAAGGCACAGGAAAAACAGATGATGCCGCAGCTCCAGCGTTGGAGACTCAGCCTCAAGGAGATGAAGAAGATATTGC
ATCACGTTACCCTACCCTTTGGACTGAACAGGTTAAAAGTCGGCAGAACAAAACCAATAAGAATTCAGTGTCATCCTGTGACCAAGAGCA
CCAGTCTGCCCTGGAGGAAGCCAAGCAGCCCAAGAACGACAATGTGGTGATCCCTGAGTGTGCGCACGGCGGCCTCTACAAGCCAGTGCA
GTGCCACCCCTCCACGGGGTACTGCTGGTGCGTCCTGGTGGACACGGGGCGCCCCATTCCCGGCACATCCACAAGGTACGAGCAGCCGAA
ATGTGACAACACGGCCAGGGCCCACCCAGCCAAAGCCCGGGACCTGTACAAGGGCCGCCAGCTACAAGGTTGTCCGGGTGCCAAAAAGCA
TGAGTTTCTGACCAGCGTTCTGGACGCGCTGTCCACGGACATGGTCCACGCCGCCTCCGACCCCTCCTCCTCGTCAGGCAGGCTCTCAGA
ACCCGACCCCAGCCATACCCTAGAGGAGCGGGTGGTGCACTGGTACTTCAAACTACTGGATAAAAACTCCAGTGGAGACATCGGCAAAAA
GGAAATCAAACCCTTCAAGAGGTTCCTTCGCAAAAAATCAAAGCCCAAAAAATGTGTGAAGAAGTTTGTTGAATACTGTGACGTGAATAA
TGACAAATCCATCTCCGTACAAGAACTGATGGGCTGCCTGGGCGTGGCGAAAGAGGACGGCAAAGCGGACACCAAGAAACGCCACACCCC
CAGAGGTCATGCTGAAAGTACGTCTAATAGACAGCCAAGGAAACAAGGATAAATGGCTCATACCCCGAAGGCAGTTCCTAGACACATGGG
AAATTTCCCTCACCAAAGAGCAATTAAGAAAACAAAAACAGAAACACATAGTATTTGCACTTTGTACTTTAAATGTAAATTCACTTTGTA
GAAATGAGCTATTTAAACAGACTGTTTTAATCTGTGAAAATGGAGAGCTGGCTTCAGAAAATTAATCACATACAATGTATGTGTCCTCTT
TTGACCTTGGAAATCTGTATGTGGTGGAGAAGTATTTGAATGCATTTAGGCTTAATTTCTTCGCCTTCCACATGTTAACAGTAGAGCTCT
ATGCACTCCGGCTGCAATCGTATGGCTTTCTCTAACCCCTGCAGTCACTTCCAGATGCCTGTGCTTACAGCATTGTGGAATCATGTTGGA
AGCTCCACATGTCCATGGAAGTTTGTGATGTACGGCCGACCCTACAGGCAGTTAACATGCATGGGCTGGTTTGTTTCTTGGGATTTTCTG
TTAGTTTGTCTTGTTTTGCTTTCCAGAGATCTTGCTCATACAATGAATCACGCAACCACTAAAGCTATCCAGTTAAGTGCAGGTAGTTCC
CCTGGAGGAAATAATATTTTCAAACTGTCGTTGGTGTGATACTTTGGCTCAAAGGATCTTTGCTTTTCCATTTTAAGCTTCTGTTTTGAG
TTTTGCCCTGGGGCTTGAATGAGTCCCAGAGAGTCGTTCGGATGGTGGGAGGCTGCCTAGGAGGCAGTAAATCCAGTCACAGTGCCTGGG
AGGGGCCCATCCTTCCAAAATGTAAATCCAGTCGCGGTGTGACCGAGCTGGCTAACAGGCTTGTCTGCCTGGTTTTCCTCCTACACGTGG
ACATTATTCTCCTGATCCTCCTACCTGGTCCACCCCAGGGCTACCGGAAGGTAAAATCTTCACCTGAACCAATTATGAGCAGTCTCCTTA
CTGAAGGTACAGCCGGATACGTGGTGCCCCCGGGGCTGGTGTTGGCAGCCGGGGGGAGGTGCCTGAGGGTCCCCACGGTTCCTTTCTGCT
TTTCTGAATGCATCAAGGGTACGAGAACTTGCCAATGGGAAATTCATCCGAGTGGCACTGGCAGAGAAGGATAGGAGTGGAATGCCCACA
CAGTGACCAACAGAACTGGTCTGCGTGCATAACCAGCTGCCACCCTCAGGCCTGGGCCCCAGAGCTCAGGGCACCCAGTGTCTTAAGGAA
CCATTTGGAGGACAGTCTGAGAGCAGGAACTTCAAGCTGTGATTCTATCTCGGCTCAGACTTTTGGTTGGAAAAAGATCTTCATGGCCCC
AAATCCCCTGAGACATGCCTTGTAGAATGATTTTGTGATGTTGTGATGCTTGTGGAGCATCGCGTAAGGCTTCTTGCTTATTTAAACTGT
GCAAGGTAAAAATCAAGCCTTTGGAGCCACAGAACCAGCTCAAGTACATGCCAATGTTGTTTAAGAAACAGTTATGATCCTAAACTTTTT

>40473_40473_2_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000264741_SMOC2_chr6_168910594_ENST00000356284_length(amino acids)=983AA_BP=564
MGMGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCR
VHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIP
CYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGA
PQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDG
AYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGA
FMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGET
MGQVTEKLQLTYMEETCRHYVAHVKFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAE
RKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTDDAAAPALETQPQ
GDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTS
TRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNS

--------------------------------------------------------------
>40473_40473_3_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000422441_SMOC2_chr6_168910594_ENST00000354536_length(transcript)=4795nt_BP=1949nt
CCGCCCGGCCCGGGACCCGCTCGCGCAGACTTCTCGGGCGGACTGAGGACGCCGCCGCTCGGGGCCGCCCCTGTGCTCGCCTTCAGCGCC
CGCTCAGCCCGCCGTCCGCGCCCCGGTGGCGGGCCCGACGCCCGCATTCCGCCCGTGTCCAGGCGCAGAGCTCCCGCCCCGGGGAGCTTC
CTGGCCGTCGGCGGGCCCCGCGGCCCGCGCGCTCGGCGCCCTGCTCGCCGGGCAGAGGGGAAGGCGGCGGCCGGCTGGGGATGGGCGGCC
CGGCTGCGCCGAGGGGCGCCGGGAGGCTCCGCGCGCTGCTGCTGGCGCTGGTGGTCGCGGGGATCCCCGCGGGCGCCTACAACCTCGACC
CGCAGCGCCCCGTGCACTTCCAGGGCCCCGCTGACTCGTTCTTCGGCTACGCAGTTCTGGAGCATTTCCACGACAACACGCGCTGGGTCC
TTGTGGGCGCACCAAAGGCAGATTCCAAATACAGCCCTTCAGTGAAGTCTCCTGGGGCTGTGTTTAAGTGCCGTGTTCACACCAACCCTG
ACCGGAGATGCACCGAACTGGACATGGCTCGAGGGAAGAATCGGGGCACGTCCTGCGGAAAGACCTGCCGGGAAGACCGCGATGATGAGT
GGATGGGGGTGAGCCTGGCCCGACAGCCCAAGGCTGATGGCCGTGTGTTGGCCTGTGCTCATCGCTGGAAGAACATCTACTATGAAGCCG
ACCACATCCTACCCCATGGCTTCTGCTACATCATCCCCTCCAACCTCCAGGCCAAAGGCAGGACGCTGATCCCTTGCTATGAAGAGTATA
AGAAGAAGTACGGAGAGGAACACGGCTCCTGCCAGGCTGGGATAGCGGGCTTCTTCACCGAGGAGCTGGTGGTGATGGGTGCTCCAGGGT
CATTTTATTGGGCTGGAACCATCAAAGTGCTGAACCTTACGGACAACACCTATTTAAAACTGAACGACGAAGTGATCATGAACAGGCGGT
ACACCTACCTGGGCTACGCAGTGACCGCTGGCCACTTCTCTCACCCGTCCACCATTGATGTGGTAGGAGGTGCCCCACAGGACAAAGGCA
TCGGCAAGGTTTATATTTTCAGAGCTGACCGAAGATCAGGCACCTTAATTAAGATCTTTCAAGCATCAGGTAAAAAGATGGGCTCTTACT
TCGGCTCCTCCTTGTGCGCAGTTGACCTGAATGGGGACGGCCTCTCTGACCTGCTGGTGGGGGCCCCCATGTTTTCTGAGATCAGGGATG
AGGGACAGGTCACTGTCTACATCAACAGAGGAAATGGAGCCCTCGAGGAGCAGCTGGCTCTGACTGGGGATGGTGCCTACAATGCGCACT
TTGGAGAGAGCATTGCCAGCCTGGACGATCTGGACAATGATGGGTTCCCAGATGTGGCCATTGGTGCACCCAAGGAGGATGACTTCGCAG
GGGCGGTCTATATCTATCATGGTGATGCCGGTGGGATAGTCCCTCAGTACTCAATGAAACTGTCTGGGCAGAAGATAAATCCAGTGCTCC
GGATGTTTGGTCAGTCCATATCGGGAGGCATTGATATGGATGGAAATGGCTATCCTGATGTCACTGTTGGAGCCTTCATGTCCGACAGCG
TGGTTCTTCTCAGAGCAAGGCCTGTCATTACGGTGGATGTCTCCATCTTCCTCCCGGGCTCCATCAACATCACAGCGCCTCAGTGTCACG
ACGGACAGCAGCCTGTGAACTGCCTGAACGTCACCACCTGCTTCAGCTTCCATGGCAAACACGTTCCAGGAGAGATTGGCCTGAATTATG
TTCTGATGGCTGACGTGGCCAAAAAGGAGAAGGGCCAGATGCCCAGGGTCTACTTTGTGCTGCTGGGAGAGACCATGGGTCAGGTCACAG
AGAAGCTGCAGCTGACTTACATGGAGGAGACGTGTCGTCACTATGTGGCCCATGTGAAGTTTTTGAGAGTGGATCAAGATAAAGACAAGG
ATTGTAGCTTGGACTGTGCGGGTTCGCCCCAGAAACCTCTCTGCGCATCTGACGGAAGGACCTTCCTTTCCCGTTGTGAATTTCAACGTG
CCAAGTGCAAAGATCCCCAGCTAGAGATTGCATATCGAGGAAACTGCAAAGACGTGTCCAGGTGTGTGGCCGAAAGGAAGTATACCCAGG
AGCAAGCCCGGAAGGAGTTTCAGCAAGTGTTCATTCCTGAGTGCAATGACGACGGCACCTACAGTCAGGTCCAGTGTCACAGCTACACGG
GATACTGCTGGTGCGTCACGCCCAACGGGAGGCCCATCAGCGGCACTGCCGTGGCCCACAAGACGCCCCGGTGCCCGGGTTCCGTAAATG
AAAAGTTACCCCAACGCGAAGGCACAGGAAAAACAGTCTCCTTGCAAATCTTTTCCGTTCTGAATTCAGATGATGCCGCAGCTCCAGCGT
TGGAGACTCAGCCTCAAGGAGATGAAGAAGATATTGCATCACGTTACCCTACCCTTTGGACTGAACAGGTTAAAAGTCGGCAGAACAAAA
CCAATAAGAATTCAGTGTCATCCTGTGACCAAGAGCACCAGTCTGCCCTGGAGGAAGCCAAGCAGCCCAAGAACGACAATGTGGTGATCC
CTGAGTGTGCGCACGGCGGCCTCTACAAGCCAGTGCAGTGCCACCCCTCCACGGGGTACTGCTGGTGCGTCCTGGTGGACACGGGGCGCC
CCATTCCCGGCACATCCACAAGGTACGAGCAGCCGAAATGTGACAACACGGCCAGGGCCCACCCAGCCAAAGCCCGGGACCTGTACAAGG
GCCGCCAGCTACAAGGTTGTCCGGGTGCCAAAAAGCATGAGTTTCTGACCAGCGTTCTGGACGCGCTGTCCACGGACATGGTCCACGCCG
CCTCCGACCCCTCCTCCTCGTCAGGCAGGCTCTCAGAACCCGACCCCAGCCATACCCTAGAGGAGCGGGTGGTGCACTGGTACTTCAAAC
TACTGGATAAAAACTCCAGTGGAGACATCGGCAAAAAGGAAATCAAACCCTTCAAGAGGTTCCTTCGCAAAAAATCAAAGCCCAAAAAAT
GTGTGAAGAAGTTTGTTGAATACTGTGACGTGAATAATGACAAATCCATCTCCGTACAAGAACTGATGGGCTGCCTGGGCGTGGCGAAAG
AGGACGGCAAAGCGGACACCAAGAAACGCCACACCCCCAGAGGTCATGCTGAAAGTACGTCTAATAGACAGCCAAGGAAACAAGGATAAA
TGGCTCATACCCCGAAGGCAGTTCCTAGACACATGGGAAATTTCCCTCACCAAAGAGCAATTAAGAAAACAAAAACAGAAACACATAGTA
TTTGCACTTTGTACTTTAAATGTAAATTCACTTTGTAGAAATGAGCTATTTAAACAGACTGTTTTAATCTGTGAAAATGGAGAGCTGGCT
TCAGAAAATTAATCACATACAATGTATGTGTCCTCTTTTGACCTTGGAAATCTGTATGTGGTGGAGAAGTATTTGAATGCATTTAGGCTT
AATTTCTTCGCCTTCCACATGTTAACAGTAGAGCTCTATGCACTCCGGCTGCAATCGTATGGCTTTCTCTAACCCCTGCAGTCACTTCCA
GATGCCTGTGCTTACAGCATTGTGGAATCATGTTGGAAGCTCCACATGTCCATGGAAGTTTGTGATGTACGGCCGACCCTACAGGCAGTT
AACATGCATGGGCTGGTTTGTTTCTTGGGATTTTCTGTTAGTTTGTCTTGTTTTGCTTTCCAGAGATCTTGCTCATACAATGAATCACGC
AACCACTAAAGCTATCCAGTTAAGTGCAGGTAGTTCCCCTGGAGGAAATAATATTTTCAAACTGTCGTTGGTGTGATACTTTGGCTCAAA
GGATCTTTGCTTTTCCATTTTAAGCTTCTGTTTTGAGTTTTGCCCTGGGGCTTGAATGAGTCCCAGAGAGTCGTTCGGATGGTGGGAGGC
TGCCTAGGAGGCAGTAAATCCAGTCACAGTGCCTGGGAGGGGCCCATCCTTCCAAAATGTAAATCCAGTCGCGGTGTGACCGAGCTGGCT
AACAGGCTTGTCTGCCTGGTTTTCCTCCTACACGTGGACATTATTCTCCTGATCCTCCTACCTGGTCCACCCCAGGGCTACCGGAAGGTA
AAATCTTCACCTGAACCAATTATGAGCAGTCTCCTTACTGAAGGTACAGCCGGATACGTGGTGCCCCCGGGGCTGGTGTTGGCAGCCGGG
GGGAGGTGCCTGAGGGTCCCCACGGTTCCTTTCTGCTTTTCTGAATGCATCAAGGGTACGAGAACTTGCCAATGGGAAATTCATCCGAGT
GGCACTGGCAGAGAAGGATAGGAGTGGAATGCCCACACAGTGACCAACAGAACTGGTCTGCGTGCATAACCAGCTGCCACCCTCAGGCCT
GGGCCCCAGAGCTCAGGGCACCCAGTGTCTTAAGGAACCATTTGGAGGACAGTCTGAGAGCAGGAACTTCAAGCTGTGATTCTATCTCGG
CTCAGACTTTTGGTTGGAAAAAGATCTTCATGGCCCCAAATCCCCTGAGACATGCCTTGTAGAATGATTTTGTGATGTTGTGATGCTTGT
GGAGCATCGCGTAAGGCTTCTTGCTTATTTAAACTGTGCAAGGTAAAAATCAAGCCTTTGGAGCCACAGAACCAGCTCAAGTACATGCCA
ATGTTGTTTAAGAAACAGTTATGATCCTAAACTTTTTGGATAATCTTTTATATTTCTGACCTTTGAATTTAATCATTGTTCTTAGATTAA

>40473_40473_3_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000422441_SMOC2_chr6_168910594_ENST00000354536_length(amino acids)=994AA_BP=564
MGMGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCR
VHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIP
CYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGA
PQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDG
AYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGA
FMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGET
MGQVTEKLQLTYMEETCRHYVAHVKFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAE
RKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTVSLQIFSVLNSDD
AAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVL
VDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVV
HWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQP

--------------------------------------------------------------
>40473_40473_4_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000422441_SMOC2_chr6_168910594_ENST00000356284_length(transcript)=4762nt_BP=1949nt
CCGCCCGGCCCGGGACCCGCTCGCGCAGACTTCTCGGGCGGACTGAGGACGCCGCCGCTCGGGGCCGCCCCTGTGCTCGCCTTCAGCGCC
CGCTCAGCCCGCCGTCCGCGCCCCGGTGGCGGGCCCGACGCCCGCATTCCGCCCGTGTCCAGGCGCAGAGCTCCCGCCCCGGGGAGCTTC
CTGGCCGTCGGCGGGCCCCGCGGCCCGCGCGCTCGGCGCCCTGCTCGCCGGGCAGAGGGGAAGGCGGCGGCCGGCTGGGGATGGGCGGCC
CGGCTGCGCCGAGGGGCGCCGGGAGGCTCCGCGCGCTGCTGCTGGCGCTGGTGGTCGCGGGGATCCCCGCGGGCGCCTACAACCTCGACC
CGCAGCGCCCCGTGCACTTCCAGGGCCCCGCTGACTCGTTCTTCGGCTACGCAGTTCTGGAGCATTTCCACGACAACACGCGCTGGGTCC
TTGTGGGCGCACCAAAGGCAGATTCCAAATACAGCCCTTCAGTGAAGTCTCCTGGGGCTGTGTTTAAGTGCCGTGTTCACACCAACCCTG
ACCGGAGATGCACCGAACTGGACATGGCTCGAGGGAAGAATCGGGGCACGTCCTGCGGAAAGACCTGCCGGGAAGACCGCGATGATGAGT
GGATGGGGGTGAGCCTGGCCCGACAGCCCAAGGCTGATGGCCGTGTGTTGGCCTGTGCTCATCGCTGGAAGAACATCTACTATGAAGCCG
ACCACATCCTACCCCATGGCTTCTGCTACATCATCCCCTCCAACCTCCAGGCCAAAGGCAGGACGCTGATCCCTTGCTATGAAGAGTATA
AGAAGAAGTACGGAGAGGAACACGGCTCCTGCCAGGCTGGGATAGCGGGCTTCTTCACCGAGGAGCTGGTGGTGATGGGTGCTCCAGGGT
CATTTTATTGGGCTGGAACCATCAAAGTGCTGAACCTTACGGACAACACCTATTTAAAACTGAACGACGAAGTGATCATGAACAGGCGGT
ACACCTACCTGGGCTACGCAGTGACCGCTGGCCACTTCTCTCACCCGTCCACCATTGATGTGGTAGGAGGTGCCCCACAGGACAAAGGCA
TCGGCAAGGTTTATATTTTCAGAGCTGACCGAAGATCAGGCACCTTAATTAAGATCTTTCAAGCATCAGGTAAAAAGATGGGCTCTTACT
TCGGCTCCTCCTTGTGCGCAGTTGACCTGAATGGGGACGGCCTCTCTGACCTGCTGGTGGGGGCCCCCATGTTTTCTGAGATCAGGGATG
AGGGACAGGTCACTGTCTACATCAACAGAGGAAATGGAGCCCTCGAGGAGCAGCTGGCTCTGACTGGGGATGGTGCCTACAATGCGCACT
TTGGAGAGAGCATTGCCAGCCTGGACGATCTGGACAATGATGGGTTCCCAGATGTGGCCATTGGTGCACCCAAGGAGGATGACTTCGCAG
GGGCGGTCTATATCTATCATGGTGATGCCGGTGGGATAGTCCCTCAGTACTCAATGAAACTGTCTGGGCAGAAGATAAATCCAGTGCTCC
GGATGTTTGGTCAGTCCATATCGGGAGGCATTGATATGGATGGAAATGGCTATCCTGATGTCACTGTTGGAGCCTTCATGTCCGACAGCG
TGGTTCTTCTCAGAGCAAGGCCTGTCATTACGGTGGATGTCTCCATCTTCCTCCCGGGCTCCATCAACATCACAGCGCCTCAGTGTCACG
ACGGACAGCAGCCTGTGAACTGCCTGAACGTCACCACCTGCTTCAGCTTCCATGGCAAACACGTTCCAGGAGAGATTGGCCTGAATTATG
TTCTGATGGCTGACGTGGCCAAAAAGGAGAAGGGCCAGATGCCCAGGGTCTACTTTGTGCTGCTGGGAGAGACCATGGGTCAGGTCACAG
AGAAGCTGCAGCTGACTTACATGGAGGAGACGTGTCGTCACTATGTGGCCCATGTGAAGTTTTTGAGAGTGGATCAAGATAAAGACAAGG
ATTGTAGCTTGGACTGTGCGGGTTCGCCCCAGAAACCTCTCTGCGCATCTGACGGAAGGACCTTCCTTTCCCGTTGTGAATTTCAACGTG
CCAAGTGCAAAGATCCCCAGCTAGAGATTGCATATCGAGGAAACTGCAAAGACGTGTCCAGGTGTGTGGCCGAAAGGAAGTATACCCAGG
AGCAAGCCCGGAAGGAGTTTCAGCAAGTGTTCATTCCTGAGTGCAATGACGACGGCACCTACAGTCAGGTCCAGTGTCACAGCTACACGG
GATACTGCTGGTGCGTCACGCCCAACGGGAGGCCCATCAGCGGCACTGCCGTGGCCCACAAGACGCCCCGGTGCCCGGGTTCCGTAAATG
AAAAGTTACCCCAACGCGAAGGCACAGGAAAAACAGATGATGCCGCAGCTCCAGCGTTGGAGACTCAGCCTCAAGGAGATGAAGAAGATA
TTGCATCACGTTACCCTACCCTTTGGACTGAACAGGTTAAAAGTCGGCAGAACAAAACCAATAAGAATTCAGTGTCATCCTGTGACCAAG
AGCACCAGTCTGCCCTGGAGGAAGCCAAGCAGCCCAAGAACGACAATGTGGTGATCCCTGAGTGTGCGCACGGCGGCCTCTACAAGCCAG
TGCAGTGCCACCCCTCCACGGGGTACTGCTGGTGCGTCCTGGTGGACACGGGGCGCCCCATTCCCGGCACATCCACAAGGTACGAGCAGC
CGAAATGTGACAACACGGCCAGGGCCCACCCAGCCAAAGCCCGGGACCTGTACAAGGGCCGCCAGCTACAAGGTTGTCCGGGTGCCAAAA
AGCATGAGTTTCTGACCAGCGTTCTGGACGCGCTGTCCACGGACATGGTCCACGCCGCCTCCGACCCCTCCTCCTCGTCAGGCAGGCTCT
CAGAACCCGACCCCAGCCATACCCTAGAGGAGCGGGTGGTGCACTGGTACTTCAAACTACTGGATAAAAACTCCAGTGGAGACATCGGCA
AAAAGGAAATCAAACCCTTCAAGAGGTTCCTTCGCAAAAAATCAAAGCCCAAAAAATGTGTGAAGAAGTTTGTTGAATACTGTGACGTGA
ATAATGACAAATCCATCTCCGTACAAGAACTGATGGGCTGCCTGGGCGTGGCGAAAGAGGACGGCAAAGCGGACACCAAGAAACGCCACA
CCCCCAGAGGTCATGCTGAAAGTACGTCTAATAGACAGCCAAGGAAACAAGGATAAATGGCTCATACCCCGAAGGCAGTTCCTAGACACA
TGGGAAATTTCCCTCACCAAAGAGCAATTAAGAAAACAAAAACAGAAACACATAGTATTTGCACTTTGTACTTTAAATGTAAATTCACTT
TGTAGAAATGAGCTATTTAAACAGACTGTTTTAATCTGTGAAAATGGAGAGCTGGCTTCAGAAAATTAATCACATACAATGTATGTGTCC
TCTTTTGACCTTGGAAATCTGTATGTGGTGGAGAAGTATTTGAATGCATTTAGGCTTAATTTCTTCGCCTTCCACATGTTAACAGTAGAG
CTCTATGCACTCCGGCTGCAATCGTATGGCTTTCTCTAACCCCTGCAGTCACTTCCAGATGCCTGTGCTTACAGCATTGTGGAATCATGT
TGGAAGCTCCACATGTCCATGGAAGTTTGTGATGTACGGCCGACCCTACAGGCAGTTAACATGCATGGGCTGGTTTGTTTCTTGGGATTT
TCTGTTAGTTTGTCTTGTTTTGCTTTCCAGAGATCTTGCTCATACAATGAATCACGCAACCACTAAAGCTATCCAGTTAAGTGCAGGTAG
TTCCCCTGGAGGAAATAATATTTTCAAACTGTCGTTGGTGTGATACTTTGGCTCAAAGGATCTTTGCTTTTCCATTTTAAGCTTCTGTTT
TGAGTTTTGCCCTGGGGCTTGAATGAGTCCCAGAGAGTCGTTCGGATGGTGGGAGGCTGCCTAGGAGGCAGTAAATCCAGTCACAGTGCC
TGGGAGGGGCCCATCCTTCCAAAATGTAAATCCAGTCGCGGTGTGACCGAGCTGGCTAACAGGCTTGTCTGCCTGGTTTTCCTCCTACAC
GTGGACATTATTCTCCTGATCCTCCTACCTGGTCCACCCCAGGGCTACCGGAAGGTAAAATCTTCACCTGAACCAATTATGAGCAGTCTC
CTTACTGAAGGTACAGCCGGATACGTGGTGCCCCCGGGGCTGGTGTTGGCAGCCGGGGGGAGGTGCCTGAGGGTCCCCACGGTTCCTTTC
TGCTTTTCTGAATGCATCAAGGGTACGAGAACTTGCCAATGGGAAATTCATCCGAGTGGCACTGGCAGAGAAGGATAGGAGTGGAATGCC
CACACAGTGACCAACAGAACTGGTCTGCGTGCATAACCAGCTGCCACCCTCAGGCCTGGGCCCCAGAGCTCAGGGCACCCAGTGTCTTAA
GGAACCATTTGGAGGACAGTCTGAGAGCAGGAACTTCAAGCTGTGATTCTATCTCGGCTCAGACTTTTGGTTGGAAAAAGATCTTCATGG
CCCCAAATCCCCTGAGACATGCCTTGTAGAATGATTTTGTGATGTTGTGATGCTTGTGGAGCATCGCGTAAGGCTTCTTGCTTATTTAAA
CTGTGCAAGGTAAAAATCAAGCCTTTGGAGCCACAGAACCAGCTCAAGTACATGCCAATGTTGTTTAAGAAACAGTTATGATCCTAAACT

>40473_40473_4_ITGA9-SMOC2_ITGA9_chr3_37584076_ENST00000422441_SMOC2_chr6_168910594_ENST00000356284_length(amino acids)=983AA_BP=564
MGMGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCR
VHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIP
CYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGA
PQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDG
AYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGA
FMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGET
MGQVTEKLQLTYMEETCRHYVAHVKFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAE
RKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTDDAAAPALETQPQ
GDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTS
TRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNS

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Fusion Gene PPI Analysis for ITGA9-SMOC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGA9-SMOC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGA9-SMOC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource