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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGAV-FARP2 (FusionGDB2 ID:40490)

Fusion Gene Summary for ITGAV-FARP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGAV-FARP2
Fusion gene ID: 40490
HgeneTgene
Gene symbol

ITGAV

FARP2

Gene ID

3685

9855

Gene nameintegrin subunit alpha VFERM, ARH/RhoGEF and pleckstrin domain protein 2
SynonymsCD51|MSK8|VNRA|VTNRFIR|FRG|PLEKHC3
Cytomap

2q32.1

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alphaFERM, ARHGEF and pleckstrin domain-containing protein 2FERM domain including RhoGEFFERM, RhoGEF and pleckstrin domain protein 2FERM, RhoGEF and pleckstrin domain-containing protein 2FGD1-related Cdc42-GEFPH domain-containing family C member 3pleckst
Modification date2020031320200313
UniProtAcc

P06756

O94887

Ensembl transtripts involved in fusion geneENST00000474571, ENST00000261023, 
ENST00000374907, ENST00000433736, 
ENST00000264042, ENST00000373287, 
ENST00000479427, ENST00000545004, 
Fusion gene scores* DoF score11 X 9 X 8=7925 X 5 X 4=100
# samples 135
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGAV [Title/Abstract] AND FARP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGAV(187534541)-FARP2(242429377), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGAV

GO:0007155

cell adhesion

10218736

HgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

HgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

HgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

HgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

HgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

HgeneITGAV

GO:1901388

regulation of transforming growth factor beta activation

22278742

HgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297

TgeneFARP2

GO:0016322

neuron remodeling

12351724

TgeneFARP2

GO:0016601

Rac protein signal transduction

12351724


check buttonFusion gene breakpoints across ITGAV (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FARP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-2578-01AITGAVchr2

187534541

-FARP2chr2

242429377

+
ChimerDB4LUSCTCGA-43-2578-01AITGAVchr2

187534541

+FARP2chr2

242429377

+
ChimerDB4LUSCTCGA-43-2578ITGAVchr2

187534541

+FARP2chr2

242429377

+


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Fusion Gene ORF analysis for ITGAV-FARP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000474571ENST00000264042ITGAVchr2

187534541

+FARP2chr2

242429377

+
3UTR-intronENST00000474571ENST00000373287ITGAVchr2

187534541

+FARP2chr2

242429377

+
3UTR-intronENST00000474571ENST00000479427ITGAVchr2

187534541

+FARP2chr2

242429377

+
3UTR-intronENST00000474571ENST00000545004ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000261023ENST00000373287ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000261023ENST00000479427ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000261023ENST00000545004ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000374907ENST00000373287ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000374907ENST00000479427ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000374907ENST00000545004ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000433736ENST00000373287ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000433736ENST00000479427ITGAVchr2

187534541

+FARP2chr2

242429377

+
5CDS-intronENST00000433736ENST00000545004ITGAVchr2

187534541

+FARP2chr2

242429377

+
In-frameENST00000261023ENST00000264042ITGAVchr2

187534541

+FARP2chr2

242429377

+
In-frameENST00000374907ENST00000264042ITGAVchr2

187534541

+FARP2chr2

242429377

+
In-frameENST00000433736ENST00000264042ITGAVchr2

187534541

+FARP2chr2

242429377

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261023ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+444029804937231224
ENST00000374907ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+431728573436001188
ENST00000433736ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+4158269813034411103

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261023ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.0008091750.99919087
ENST00000374907ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.0008200810.9991799
ENST00000433736ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.000749320.9992507

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Fusion Genomic Features for ITGAV-FARP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGAVchr2187534541+FARP2chr2242429376+1.93E-091
ITGAVchr2187534541+FARP2chr2242429376+1.93E-091
ITGAVchr2187534541+FARP2chr2242429376+1.93E-091
ITGAVchr2187534541+FARP2chr2242429376+1.93E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ITGAV-FARP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:187534541/chr2:242429377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGAV

P06756

FARP2

O94887

FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.FUNCTION: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630260_2689021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630314_3229021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630379_3879021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630443_4519021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428260_2688661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428314_3228661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428379_3878661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428443_4518661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630260_2688561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630314_3228561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630379_3878561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630443_4518561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630109_1709021049.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630173_2259021049.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630237_2919021049.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630292_3579021049.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+263032_989021049.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630358_4159021049.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630419_4829021049.0RepeatFG-GAP 7
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428109_1708661013.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428173_2258661013.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428237_2918661013.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428292_3578661013.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+242832_988661013.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428358_4158661013.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428419_4828661013.0RepeatFG-GAP 7
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630109_1708561003.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630173_2258561003.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630237_2918561003.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630292_3578561003.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+263032_988561003.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630358_4158561003.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630419_4828561003.0RepeatFG-GAP 7
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018425_4280648.0Compositional biasNote=Poly-Ser
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018453_5110648.0Compositional biasNote=Pro-rich
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027929_10268071055.0DomainPH 2
TgeneFARP2chr2:187534541chr2:242429377ENST0000037328701844_3240648.0DomainFERM
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018535_7260648.0DomainDH
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018755_8520648.0DomainPH 1
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018929_10260648.0DomainPH 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+26301019_10239021049.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+24281019_10238661013.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+26301019_10238561003.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+26301017_10489021049.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+263031_9929021049.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+24281017_10488661013.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+242831_9928661013.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+26301017_10488561003.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+263031_9928561003.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630993_10169021049.0TransmembraneHelical
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428993_10168661013.0TransmembraneHelical
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630993_10168561003.0TransmembraneHelical
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027425_4288071055.0Compositional biasNote=Poly-Ser
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027453_5118071055.0Compositional biasNote=Pro-rich
TgeneFARP2chr2:187534541chr2:242429377ENST00000264042202744_3248071055.0DomainFERM
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027535_7268071055.0DomainDH
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027755_8528071055.0DomainPH 1


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Fusion Gene Sequence for ITGAV-FARP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40490_40490_1_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000261023_FARP2_chr2_242429377_ENST00000264042_length(transcript)=4440nt_BP=2980nt
CCTCAGACGCTGCGTGGAGCGGCGGAGCCGGAGGGAAGCAAAGGACCGTCTGCGCTGCTGTCCCCGCCCCGCGCGCTCTGCGCCCCTCGT
CCCTGGCGGTCGCTCCGAAGCTCAGCCCTCTTGCCTGCCCCGGAGCTGTCCCGGGCTAGCCGAGAAGAGAGCGGCCGGCAAGTTTGGGCG
CGCGCAGGCGGCGGGCCGCGGGCACTGGGCGCCTCGCTGGGGCGGGGGGAGGTGGCTACCGCTCCCGGCTTGGCGTCCCGCGCGCACTTC
GGCGATGGCTTTTCCGCCGCGGCGACGGCTGCGCCTCGGTCCCCGCGGCCTCCCGCTTCTTCTCTCGGGACTCCTGCTACCTCTGTGCCG
CGCCTTCAACCTAGACGTGGACAGTCCTGCCGAGTACTCTGGCCCCGAGGGAAGTTACTTCGGCTTCGCCGTGGATTTCTTCGTGCCCAG
CGCGTCTTCCCGGATGTTTCTTCTCGTGGGAGCTCCCAAAGCAAACACCACCCAGCCTGGGATTGTGGAAGGAGGGCAGGTCCTCAAATG
TGACTGGTCTTCTACCCGCCGGTGCCAGCCAATTGAATTTGATGCAACAGGCAATAGAGATTATGCCAAGGATGATCCATTGGAATTTAA
GTCCCATCAGTGGTTTGGAGCATCTGTGAGGTCGAAACAGGATAAAATTTTGGCCTGTGCCCCATTGTACCATTGGAGAACTGAGATGAA
ACAGGAGCGAGAGCCTGTTGGAACATGCTTTCTTCAAGATGGAACAAAGACTGTTGAGTATGCTCCATGTAGATCACAAGATATTGATGC
TGATGGACAGGGATTTTGTCAAGGAGGATTCAGCATTGATTTTACTAAAGCTGACAGAGTACTTCTTGGTGGTCCTGGTAGCTTTTATTG
GCAAGGTCAGCTTATTTCGGATCAAGTGGCAGAAATCGTATCTAAATACGACCCCAATGTTTACAGCATCAAGTATAATAACCAATTAGC
AACTCGGACTGCACAAGCTATTTTTGATGACAGCTATTTGGGTTATTCTGTGGCTGTCGGAGATTTCAATGGTGATGGCATAGATGACTT
TGTTTCAGGAGTTCCAAGAGCAGCAAGGACTTTGGGAATGGTTTATATTTATGATGGGAAGAACATGTCCTCCTTATACAATTTTACTGG
CGAGCAGATGGCTGCATATTTCGGATTTTCTGTAGCTGCCACTGACATTAATGGAGATGATTATGCAGATGTGTTTATTGGAGCACCTCT
CTTCATGGATCGTGGCTCTGATGGCAAACTCCAAGAGGTGGGGCAGGTCTCAGTGTCTCTACAGAGAGCTTCAGGAGACTTCCAGACGAC
AAAGCTGAATGGATTTGAGGTCTTTGCACGGTTTGGCAGTGCCATAGCTCCTTTGGGAGATCTGGACCAGGATGGTTTCAATGATATTGC
AATTGCTGCTCCATATGGGGGTGAAGATAAAAAAGGAATTGTTTATATCTTCAATGGAAGATCAACAGGCTTGAACGCAGTCCCATCTCA
AATCCTTGAAGGGCAGTGGGCTGCTCGAAGCATGCCACCAAGCTTTGGCTATTCAATGAAAGGAGCCACAGATATAGACAAAAATGGATA
TCCAGACTTAATTGTAGGAGCTTTTGGTGTAGATCGAGCTATCTTATACAGGGCCAGACCAGTTATCACTGTAAATGCTGGTCTTGAAGT
GTACCCTAGCATTTTAAATCAAGACAATAAAACCTGCTCACTGCCTGGAACAGCTCTCAAAGTTTCCTGTTTTAATGTTAGGTTCTGCTT
AAAGGCAGATGGCAAAGGAGTACTTCCCAGGAAACTTAATTTCCAGGTGGAACTTCTTTTGGATAAACTCAAGCAAAAGGGAGCAATTCG
ACGAGCACTGTTTCTCTACAGCAGGTCCCCAAGTCACTCCAAGAACATGACTATTTCAAGGGGGGGACTGATGCAGTGTGAGGAATTGAT
AGCGTATCTGCGGGATGAATCTGAATTTAGAGACAAACTCACTCCAATTACTATTTTTATGGAATATCGGTTGGATTATAGAACAGCTGC
TGATACAACAGGCTTGCAACCCATTCTTAACCAGTTCACGCCTGCTAACATTAGTCGACAGGCTCACATTCTACTTGACTGTGGTGAAGA
CAATGTCTGTAAACCCAAGCTGGAAGTTTCTGTAGATAGTGATCAAAAGAAGATCTATATTGGGGATGACAACCCTCTGACATTGATTGT
TAAGGCTCAGAATCAAGGAGAAGGTGCCTACGAAGCTGAGCTCATCGTTTCCATTCCACTGCAGGCTGATTTCATCGGGGTTGTCCGAAA
CAATGAAGCCTTAGCAAGACTTTCCTGTGCATTTAAGACAGAAAACCAAACTCGCCAGGTGGTATGTGACCTTGGAAACCCAATGAAGGC
TGGAACTCAACTCTTAGCTGGTCTTCGTTTCAGTGTGCACCAGCAGTCAGAGATGGATACTTCTGTGAAATTTGACTTACAAATCCAAAG
CTCAAATCTATTTGACAAAGTAAGCCCAGTTGTATCTCACAAAGTTGATCTTGCTGTTTTAGCTGCAGTTGAGATAAGAGGAGTCTCGAG
TCCTGATCATGTCTTTCTTCCGATTCCAAACTGGGAGCACAAGGAGAACCCTGAGACTGAAGAAGATGTTGGGCCAGTTGTTCAGCACAT
CTATGAGCTGAGAAACAATGGTCCAAGTTCATTCAGCAAGGCAATGCTCCATCTTCAGTGGCCTTACAAATATAATAATAACACTCTGTT
GTATATCCTTCATTATGATATTGATGGACCAATGAACTGCACTTCAGATATGGAGATCAACCCTTTGAGAATTAAGATCTCATCTTTGCA
AACAACTGAAAAGAATGACACGGTTGCCGGGCAAGGTGAGCGGGACCATCTCATCACTAAGCGGGATCTTGCCCTCAGTGAAGGAGATAT
TCACACTTTGGTGGAAGAAAGTGATAACGAGTGGTCTGTTCCACACTGTTTCACCATCTACGCGGCTCAGAAAACAATCGTGGTGGCAGC
CAGCACTCGGCTGGAGAAAGAGAAGTGGATGCTGGACCTGAACTCCGCGATCCAAGCAGCCAAGAGTGGCGGTGACACGGCCCCTGCACT
GCCAGGCCGCACTGTGTGCACTCGTCCCCCCAGATCCCCCAACGAGGTATCTCTGGAGCAGGAGTCAGAAGATGATGCTCGGGGTGTCCG
CAGCTCCCTGGAGGGGCATGGCCAGCACCGGGCCAACACCACAATGCACGTGTGCTGGTACCGGAACACCAGCGTGTCCAGGGCAGACCA
CAGTGCAGCTGTCGAGAACCAGCTTTCAGGATATCTGCTAAGAAAGTTCAAAAACAGTCATGGCTGGCAGAAGCTCTGGGTCGTCTTTAC
CAACTTCTGTTTGTTCTTCTACAAAACTCATCAGGATGACTACCCACTGGCCAGCCTCCCGCTGCTGGGCTACAGCGTGAGCATCCCCAG
GGAGGCCGATGGCATACACAAAGACTATGTTTTCAAGCTCCAGTTCAAATCCCACGTCTACTTCTTCCGGGCTGAGAGCAAGTACACATT
TGAAAGGTGGATGGAGGTGATCCAGGGGGCCAGCAGCTCAGCCGGGAGGGCCCCAAGCATCGTGCAGGATGGCCCCCAACCCTCCTCAGG
GCTGGAGGGGATGGTCAGGGGGAAGGAGGAATGACGCTCAACCTGCCCAGGTTTGGACACAACTACAAAGAACAGCAGGACACAGAGGTG
ACCTCTGTCCTGAGGCTTCTCAACAGATGGGAAGTGGCTGTGGTCTCACTGGATCCCCACTGGCACCAGCAGTGTGGGTGGGCCTCATGT
AACATCTGGGAGGGGCTTCATCCCCCCACCCAGGACCTAGTGCATGCCAGCAGCTATCTGGGGCCCTGGGAAAAATGTGCGAGTCTTGAG
CGCGGAGCCGCTCAAGCCACAGCTCCCAGGCCCCTGGCTCAAAGACGCAGACAAGGCCTGAGCAGTGCTCTCGGCATCGGACCAAAGCCT
GGGCACACCCTGCCTCTCTCCCCAGAGCAGGGTCCCTGCCGAGGACTGGCCTAGAGCAAGCACTGGAAAAGAGGCCCTGCCATACACCCT
GCGTACCCACTGCCAGGACCCTCTCAGACAAGCGTGGCACAGCCATGCTGACCTTCCATCTGGTGAACCAAGTGGCAGCCCCAGGGGCCT
GCCCTGCAGGTCACAGCTAAACAAGTCTGGCAGAAGCCACGCTTGTTCCCCATGTACCTCTAGAGAAGCAGAAACCAAAGTCCCCCTGTG
CCCTGGGAGGGTGGGGCCGTCTAATTTATTACTGCCCAGCATTCCTTCCAACGGGAAGTAGATGGGCGACTGCTTTGTTCACACACATTT

>40490_40490_1_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000261023_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1224AA_BP=977
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTK
ADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYI
YDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIA
PLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILY
RARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNM
TISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQK
KIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQS
EMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAML
HLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHC
FTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMH
VCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFK

--------------------------------------------------------------
>40490_40490_2_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000374907_FARP2_chr2_242429377_ENST00000264042_length(transcript)=4317nt_BP=2857nt
GGAGCGGCGGAGCCGGAGGGAAGCAAAGGACCGTCTGCGCTGCTGTCCCCGCCCCGCGCGCTCTGCGCCCCTCGTCCCTGGCGGTCGCTC
CGAAGCTCAGCCCTCTTGCCTGCCCCGGAGCTGTCCCGGGCTAGCCGAGAAGAGAGCGGCCGGCAAGTTTGGGCGCGCGCAGGCGGCGGG
CCGCGGGCACTGGGCGCCTCGCTGGGGCGGGGGGAGGTGGCTACCGCTCCCGGCTTGGCGTCCCGCGCGCACTTCGGCGATGGCTTTTCC
GCCGCGGCGACGGCTGCGCCTCGGTCCCCGCGGCCTCCCGCTTCTTCTCTCGGGACTCCTGCTACCTCTGTGCCGCGCCTTCAACCTAGA
CGTGGACAGTCCTGCCGAGTACTCTGGCCCCGAGGGAAGTTACTTCGGCTTCGCCGTGGATTTCTTCGTGCCCAGCGCGTCTTCCCGGAT
GTTTCTTCTCGTGGGAGCTCCCAAAGCAAACACCACCCAGCCTGGGATTGTGGAAGGAGGGCAGGTCCTCAAATGTGACTGGTCTTCTAC
CCGCCGGTGCCAGCCAATTGAATTTGATGCAACAGGCAATAGAGATTATGCCAAGGATGATCCATTGGAATTTAAGTCCCATCAGTGGTT
TGGAGCATCTGTGAGGTCGAAACAGGATAAAATTTTGGCCTGTGCCCCATTGTACCATTGGAGAACTGAGATGAAACAGGAGCGAGAGCC
TGTTGGAACATGCTTTCTTCAAGATGGAACAAAGACTGTTGAGTATGCTCCATGTAGATCACGTCAGCTTATTTCGGATCAAGTGGCAGA
AATCGTATCTAAATACGACCCCAATGTTTACAGCATCAAGTATAATAACCAATTAGCAACTCGGACTGCACAAGCTATTTTTGATGACAG
CTATTTGGGTTATTCTGTGGCTGTCGGAGATTTCAATGGTGATGGCATAGATGACTTTGTTTCAGGAGTTCCAAGAGCAGCAAGGACTTT
GGGAATGGTTTATATTTATGATGGGAAGAACATGTCCTCCTTATACAATTTTACTGGCGAGCAGATGGCTGCATATTTCGGATTTTCTGT
AGCTGCCACTGACATTAATGGAGATGATTATGCAGATGTGTTTATTGGAGCACCTCTCTTCATGGATCGTGGCTCTGATGGCAAACTCCA
AGAGGTGGGGCAGGTCTCAGTGTCTCTACAGAGAGCTTCAGGAGACTTCCAGACGACAAAGCTGAATGGATTTGAGGTCTTTGCACGGTT
TGGCAGTGCCATAGCTCCTTTGGGAGATCTGGACCAGGATGGTTTCAATGATATTGCAATTGCTGCTCCATATGGGGGTGAAGATAAAAA
AGGAATTGTTTATATCTTCAATGGAAGATCAACAGGCTTGAACGCAGTCCCATCTCAAATCCTTGAAGGGCAGTGGGCTGCTCGAAGCAT
GCCACCAAGCTTTGGCTATTCAATGAAAGGAGCCACAGATATAGACAAAAATGGATATCCAGACTTAATTGTAGGAGCTTTTGGTGTAGA
TCGAGCTATCTTATACAGGGCCAGACCAGTTATCACTGTAAATGCTGGTCTTGAAGTGTACCCTAGCATTTTAAATCAAGACAATAAAAC
CTGCTCACTGCCTGGAACAGCTCTCAAAGTTTCCTGTTTTAATGTTAGGTTCTGCTTAAAGGCAGATGGCAAAGGAGTACTTCCCAGGAA
ACTTAATTTCCAGGTGGAACTTCTTTTGGATAAACTCAAGCAAAAGGGAGCAATTCGACGAGCACTGTTTCTCTACAGCAGGTCCCCAAG
TCACTCCAAGAACATGACTATTTCAAGGGGGGGACTGATGCAGTGTGAGGAATTGATAGCGTATCTGCGGGATGAATCTGAATTTAGAGA
CAAACTCACTCCAATTACTATTTTTATGGAATATCGGTTGGATTATAGAACAGCTGCTGATACAACAGGCTTGCAACCCATTCTTAACCA
GTTCACGCCTGCTAACATTAGTCGACAGGCTCACATTCTACTTGACTGTGGTGAAGACAATGTCTGTAAACCCAAGCTGGAAGTTTCTGT
AGATAGTGATCAAAAGAAGATCTATATTGGGGATGACAACCCTCTGACATTGATTGTTAAGGCTCAGAATCAAGGAGAAGGTGCCTACGA
AGCTGAGCTCATCGTTTCCATTCCACTGCAGGCTGATTTCATCGGGGTTGTCCGAAACAATGAAGCCTTAGCAAGACTTTCCTGTGCATT
TAAGACAGAAAACCAAACTCGCCAGGTGGTATGTGACCTTGGAAACCCAATGAAGGCTGGAACTCAACTCTTAGCTGGTCTTCGTTTCAG
TGTGCACCAGCAGTCAGAGATGGATACTTCTGTGAAATTTGACTTACAAATCCAAAGCTCAAATCTATTTGACAAAGTAAGCCCAGTTGT
ATCTCACAAAGTTGATCTTGCTGTTTTAGCTGCAGTTGAGATAAGAGGAGTCTCGAGTCCTGATCATGTCTTTCTTCCGATTCCAAACTG
GGAGCACAAGGAGAACCCTGAGACTGAAGAAGATGTTGGGCCAGTTGTTCAGCACATCTATGAGCTGAGAAACAATGGTCCAAGTTCATT
CAGCAAGGCAATGCTCCATCTTCAGTGGCCTTACAAATATAATAATAACACTCTGTTGTATATCCTTCATTATGATATTGATGGACCAAT
GAACTGCACTTCAGATATGGAGATCAACCCTTTGAGAATTAAGATCTCATCTTTGCAAACAACTGAAAAGAATGACACGGTTGCCGGGCA
AGGTGAGCGGGACCATCTCATCACTAAGCGGGATCTTGCCCTCAGTGAAGGAGATATTCACACTTTGGTGGAAGAAAGTGATAACGAGTG
GTCTGTTCCACACTGTTTCACCATCTACGCGGCTCAGAAAACAATCGTGGTGGCAGCCAGCACTCGGCTGGAGAAAGAGAAGTGGATGCT
GGACCTGAACTCCGCGATCCAAGCAGCCAAGAGTGGCGGTGACACGGCCCCTGCACTGCCAGGCCGCACTGTGTGCACTCGTCCCCCCAG
ATCCCCCAACGAGGTATCTCTGGAGCAGGAGTCAGAAGATGATGCTCGGGGTGTCCGCAGCTCCCTGGAGGGGCATGGCCAGCACCGGGC
CAACACCACAATGCACGTGTGCTGGTACCGGAACACCAGCGTGTCCAGGGCAGACCACAGTGCAGCTGTCGAGAACCAGCTTTCAGGATA
TCTGCTAAGAAAGTTCAAAAACAGTCATGGCTGGCAGAAGCTCTGGGTCGTCTTTACCAACTTCTGTTTGTTCTTCTACAAAACTCATCA
GGATGACTACCCACTGGCCAGCCTCCCGCTGCTGGGCTACAGCGTGAGCATCCCCAGGGAGGCCGATGGCATACACAAAGACTATGTTTT
CAAGCTCCAGTTCAAATCCCACGTCTACTTCTTCCGGGCTGAGAGCAAGTACACATTTGAAAGGTGGATGGAGGTGATCCAGGGGGCCAG
CAGCTCAGCCGGGAGGGCCCCAAGCATCGTGCAGGATGGCCCCCAACCCTCCTCAGGGCTGGAGGGGATGGTCAGGGGGAAGGAGGAATG
ACGCTCAACCTGCCCAGGTTTGGACACAACTACAAAGAACAGCAGGACACAGAGGTGACCTCTGTCCTGAGGCTTCTCAACAGATGGGAA
GTGGCTGTGGTCTCACTGGATCCCCACTGGCACCAGCAGTGTGGGTGGGCCTCATGTAACATCTGGGAGGGGCTTCATCCCCCCACCCAG
GACCTAGTGCATGCCAGCAGCTATCTGGGGCCCTGGGAAAAATGTGCGAGTCTTGAGCGCGGAGCCGCTCAAGCCACAGCTCCCAGGCCC
CTGGCTCAAAGACGCAGACAAGGCCTGAGCAGTGCTCTCGGCATCGGACCAAAGCCTGGGCACACCCTGCCTCTCTCCCCAGAGCAGGGT
CCCTGCCGAGGACTGGCCTAGAGCAAGCACTGGAAAAGAGGCCCTGCCATACACCCTGCGTACCCACTGCCAGGACCCTCTCAGACAAGC
GTGGCACAGCCATGCTGACCTTCCATCTGGTGAACCAAGTGGCAGCCCCAGGGGCCTGCCCTGCAGGTCACAGCTAAACAAGTCTGGCAG
AAGCCACGCTTGTTCCCCATGTACCTCTAGAGAAGCAGAAACCAAAGTCCCCCTGTGCCCTGGGAGGGTGGGGCCGTCTAATTTATTACT

>40490_40490_2_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000374907_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1188AA_BP=941
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSRQLISDQVAEIVSKYDPNVYS
IKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYA
DVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRST
GLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVS
CFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEY
RLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQA
DFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAA
VEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPL
RIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKS
GGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGW
QKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQ

--------------------------------------------------------------
>40490_40490_3_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000433736_FARP2_chr2_242429377_ENST00000264042_length(transcript)=4158nt_BP=2698nt
CTTTGTAGCTCCTGGAGATTCAATTCTTTCTTGCCAGGGTCTTTCTACCTCTGCCTCACATATTCCCTCCATCTCTTCATTCCACTTCCC
TCATCCCCACCCCCCACTCCCCTCCATCCTCAATACACAAATGCTCCTAGGCACCCTCCTTCTGATCCTGTACATCTTAATGTTGTGCCG
GATGTTTCTTCTCGTGGGAGCTCCCAAAGCAAACACCACCCAGCCTGGGATTGTGGAAGGAGGGCAGGTCCTCAAATGTGACTGGTCTTC
TACCCGCCGGTGCCAGCCAATTGAATTTGATGCAACAGGCAATAGAGATTATGCCAAGGATGATCCATTGGAATTTAAGTCCCATCAGTG
GTTTGGAGCATCTGTGAGGTCGAAACAGGATAAAATTTTGGCCTGTGCCCCATTGTACCATTGGAGAACTGAGATGAAACAGGAGCGAGA
GCCTGTTGGAACATGCTTTCTTCAAGATGGAACAAAGACTGTTGAGTATGCTCCATGTAGATCACAAGATATTGATGCTGATGGACAGGG
ATTTTGTCAAGGAGGATTCAGCATTGATTTTACTAAAGCTGACAGAGTACTTCTTGGTGGTCCTGGTAGCTTTTATTGGCAAGGTCAGCT
TATTTCGGATCAAGTGGCAGAAATCGTATCTAAATACGACCCCAATGTTTACAGCATCAAGTATAATAACCAATTAGCAACTCGGACTGC
ACAAGCTATTTTTGATGACAGCTATTTGGGTTATTCTGTGGCTGTCGGAGATTTCAATGGTGATGGCATAGATGACTTTGTTTCAGGAGT
TCCAAGAGCAGCAAGGACTTTGGGAATGGTTTATATTTATGATGGGAAGAACATGTCCTCCTTATACAATTTTACTGGCGAGCAGATGGC
TGCATATTTCGGATTTTCTGTAGCTGCCACTGACATTAATGGAGATGATTATGCAGATGTGTTTATTGGAGCACCTCTCTTCATGGATCG
TGGCTCTGATGGCAAACTCCAAGAGGTGGGGCAGGTCTCAGTGTCTCTACAGAGAGCTTCAGGAGACTTCCAGACGACAAAGCTGAATGG
ATTTGAGGTCTTTGCACGGTTTGGCAGTGCCATAGCTCCTTTGGGAGATCTGGACCAGGATGGTTTCAATGATATTGCAATTGCTGCTCC
ATATGGGGGTGAAGATAAAAAAGGAATTGTTTATATCTTCAATGGAAGATCAACAGGCTTGAACGCAGTCCCATCTCAAATCCTTGAAGG
GCAGTGGGCTGCTCGAAGCATGCCACCAAGCTTTGGCTATTCAATGAAAGGAGCCACAGATATAGACAAAAATGGATATCCAGACTTAAT
TGTAGGAGCTTTTGGTGTAGATCGAGCTATCTTATACAGGGCCAGACCAGTTATCACTGTAAATGCTGGTCTTGAAGTGTACCCTAGCAT
TTTAAATCAAGACAATAAAACCTGCTCACTGCCTGGAACAGCTCTCAAAGTTTCCTGTTTTAATGTTAGGTTCTGCTTAAAGGCAGATGG
CAAAGGAGTACTTCCCAGGAAACTTAATTTCCAGGTGGAACTTCTTTTGGATAAACTCAAGCAAAAGGGAGCAATTCGACGAGCACTGTT
TCTCTACAGCAGGTCCCCAAGTCACTCCAAGAACATGACTATTTCAAGGGGGGGACTGATGCAGTGTGAGGAATTGATAGCGTATCTGCG
GGATGAATCTGAATTTAGAGACAAACTCACTCCAATTACTATTTTTATGGAATATCGGTTGGATTATAGAACAGCTGCTGATACAACAGG
CTTGCAACCCATTCTTAACCAGTTCACGCCTGCTAACATTAGTCGACAGGCTCACATTCTACTTGACTGTGGTGAAGACAATGTCTGTAA
ACCCAAGCTGGAAGTTTCTGTAGATAGTGATCAAAAGAAGATCTATATTGGGGATGACAACCCTCTGACATTGATTGTTAAGGCTCAGAA
TCAAGGAGAAGGTGCCTACGAAGCTGAGCTCATCGTTTCCATTCCACTGCAGGCTGATTTCATCGGGGTTGTCCGAAACAATGAAGCCTT
AGCAAGACTTTCCTGTGCATTTAAGACAGAAAACCAAACTCGCCAGGTGGTATGTGACCTTGGAAACCCAATGAAGGCTGGAACTCAACT
CTTAGCTGGTCTTCGTTTCAGTGTGCACCAGCAGTCAGAGATGGATACTTCTGTGAAATTTGACTTACAAATCCAAAGCTCAAATCTATT
TGACAAAGTAAGCCCAGTTGTATCTCACAAAGTTGATCTTGCTGTTTTAGCTGCAGTTGAGATAAGAGGAGTCTCGAGTCCTGATCATGT
CTTTCTTCCGATTCCAAACTGGGAGCACAAGGAGAACCCTGAGACTGAAGAAGATGTTGGGCCAGTTGTTCAGCACATCTATGAGCTGAG
AAACAATGGTCCAAGTTCATTCAGCAAGGCAATGCTCCATCTTCAGTGGCCTTACAAATATAATAATAACACTCTGTTGTATATCCTTCA
TTATGATATTGATGGACCAATGAACTGCACTTCAGATATGGAGATCAACCCTTTGAGAATTAAGATCTCATCTTTGCAAACAACTGAAAA
GAATGACACGGTTGCCGGGCAAGGTGAGCGGGACCATCTCATCACTAAGCGGGATCTTGCCCTCAGTGAAGGAGATATTCACACTTTGGT
GGAAGAAAGTGATAACGAGTGGTCTGTTCCACACTGTTTCACCATCTACGCGGCTCAGAAAACAATCGTGGTGGCAGCCAGCACTCGGCT
GGAGAAAGAGAAGTGGATGCTGGACCTGAACTCCGCGATCCAAGCAGCCAAGAGTGGCGGTGACACGGCCCCTGCACTGCCAGGCCGCAC
TGTGTGCACTCGTCCCCCCAGATCCCCCAACGAGGTATCTCTGGAGCAGGAGTCAGAAGATGATGCTCGGGGTGTCCGCAGCTCCCTGGA
GGGGCATGGCCAGCACCGGGCCAACACCACAATGCACGTGTGCTGGTACCGGAACACCAGCGTGTCCAGGGCAGACCACAGTGCAGCTGT
CGAGAACCAGCTTTCAGGATATCTGCTAAGAAAGTTCAAAAACAGTCATGGCTGGCAGAAGCTCTGGGTCGTCTTTACCAACTTCTGTTT
GTTCTTCTACAAAACTCATCAGGATGACTACCCACTGGCCAGCCTCCCGCTGCTGGGCTACAGCGTGAGCATCCCCAGGGAGGCCGATGG
CATACACAAAGACTATGTTTTCAAGCTCCAGTTCAAATCCCACGTCTACTTCTTCCGGGCTGAGAGCAAGTACACATTTGAAAGGTGGAT
GGAGGTGATCCAGGGGGCCAGCAGCTCAGCCGGGAGGGCCCCAAGCATCGTGCAGGATGGCCCCCAACCCTCCTCAGGGCTGGAGGGGAT
GGTCAGGGGGAAGGAGGAATGACGCTCAACCTGCCCAGGTTTGGACACAACTACAAAGAACAGCAGGACACAGAGGTGACCTCTGTCCTG
AGGCTTCTCAACAGATGGGAAGTGGCTGTGGTCTCACTGGATCCCCACTGGCACCAGCAGTGTGGGTGGGCCTCATGTAACATCTGGGAG
GGGCTTCATCCCCCCACCCAGGACCTAGTGCATGCCAGCAGCTATCTGGGGCCCTGGGAAAAATGTGCGAGTCTTGAGCGCGGAGCCGCT
CAAGCCACAGCTCCCAGGCCCCTGGCTCAAAGACGCAGACAAGGCCTGAGCAGTGCTCTCGGCATCGGACCAAAGCCTGGGCACACCCTG
CCTCTCTCCCCAGAGCAGGGTCCCTGCCGAGGACTGGCCTAGAGCAAGCACTGGAAAAGAGGCCCTGCCATACACCCTGCGTACCCACTG
CCAGGACCCTCTCAGACAAGCGTGGCACAGCCATGCTGACCTTCCATCTGGTGAACCAAGTGGCAGCCCCAGGGGCCTGCCCTGCAGGTC
ACAGCTAAACAAGTCTGGCAGAAGCCACGCTTGTTCCCCATGTACCTCTAGAGAAGCAGAAACCAAAGTCCCCCTGTGCCCTGGGAGGGT
GGGGCCGTCTAATTTATTACTGCCCAGCATTCCTTCCAACGGGAAGTAGATGGGCGACTGCTTTGTTCACACACATTTGATTAAAAATAA

>40490_40490_3_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000433736_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1103AA_BP=856
MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKIL
ACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYD
PNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDIN
GDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF
NGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGT
ALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPIT
IFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVS
IPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDL
AVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDM
EINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAI
QAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFK
NSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRA

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Fusion Gene PPI Analysis for ITGAV-FARP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGAV-FARP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGAV-FARP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource