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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGB6-SH3PXD2B (FusionGDB2 ID:40574)

Fusion Gene Summary for ITGB6-SH3PXD2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB6-SH3PXD2B
Fusion gene ID: 40574
HgeneTgene
Gene symbol

ITGB6

SH3PXD2B

Gene ID

3694

285590

Gene nameintegrin subunit beta 6SH3 and PX domains 2B
SynonymsAI1HFAD49|FTHS|HOFI|KIAA1295|TKS4|TSK4
Cytomap

2q24.2

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-6integrin, beta 6SH3 and PX domain-containing protein 2Badapter protein HOFIadaptor protein HOFIfactor for adipocyte differentiation 49tyrosine kinase substrate with four SH3 domains
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000283249, ENST00000409872, 
ENST00000409967, ENST00000428609, 
ENST00000485635, 		ENST00000523651, 
ENST00000311601, ENST00000519643, 
Fusion gene scores* DoF score7 X 10 X 6=4205 X 5 X 4=100
# samples 146
** MAII scorelog2(14/420*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB6 [Title/Abstract] AND SH3PXD2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB6(161025723)-SH3PXD2B(171849500), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGB6-SH3PXD2B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ITGB6-SH3PXD2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB6

GO:0033627

cell adhesion mediated by integrin

17158881

HgeneITGB6

GO:1901388

regulation of transforming growth factor beta activation

22278742

TgeneSH3PXD2B

GO:0006801

superoxide metabolic process

19755710

TgeneSH3PXD2B

GO:0072657

protein localization to membrane

19755710


check buttonFusion gene breakpoints across ITGB6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH3PXD2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8091-01AITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-


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Fusion Gene ORF analysis for ITGB6-SH3PXD2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283249ENST00000523651ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5CDS-intronENST00000409872ENST00000523651ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5CDS-intronENST00000409967ENST00000523651ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5CDS-intronENST00000428609ENST00000523651ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5UTR-3CDSENST00000485635ENST00000311601ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5UTR-3CDSENST00000485635ENST00000519643ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
5UTR-intronENST00000485635ENST00000523651ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
Frame-shiftENST00000409872ENST00000311601ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
Frame-shiftENST00000409872ENST00000519643ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000283249ENST00000311601ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000283249ENST00000519643ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000409967ENST00000311601ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000409967ENST00000519643ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000428609ENST00000311601ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-
In-frameENST00000428609ENST00000519643ITGB6chr2

161025723

-SH3PXD2Bchr5

171849500

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283249ITGB6chr2161025723-ENST00000519643SH3PXD2Bchr5171849500-256812552292472747
ENST00000283249ITGB6chr2161025723-ENST00000311601SH3PXD2Bchr5171849500-8786125522939151228
ENST00000428609ITGB6chr2161025723-ENST00000519643SH3PXD2Bchr5171849500-243911262352343702
ENST00000428609ITGB6chr2161025723-ENST00000311601SH3PXD2Bchr5171849500-8657112623537861183
ENST00000409967ITGB6chr2161025723-ENST00000519643SH3PXD2Bchr5171849500-252512121862429747
ENST00000409967ITGB6chr2161025723-ENST00000311601SH3PXD2Bchr5171849500-8743121218638721228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283249ENST00000519643ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.0011799890.99882
ENST00000283249ENST00000311601ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.0011305860.99886936
ENST00000428609ENST00000519643ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.0017657010.9982343
ENST00000428609ENST00000311601ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.001157130.99884284
ENST00000409967ENST00000519643ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.001292930.99870706
ENST00000409967ENST00000311601ITGB6chr2161025723-SH3PXD2Bchr5171849500-0.0011083750.99889165

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Fusion Genomic Features for ITGB6-SH3PXD2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITGB6-SH3PXD2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:161025723/chr5:171849500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST00000311601013729_80625912.0Compositional biasNote=Pro-rich
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST00000311601013152_21125912.0DomainSH3 1
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST00000311601013221_28025912.0DomainSH3 2
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST00000311601013368_42725912.0DomainSH3 3
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST00000311601013850_91125912.0DomainSH3 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715131_371339789.0DomainNote=VWFA
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816131_371339789.0DomainNote=VWFA
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715456_619339789.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816456_619339789.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715456_501339789.0RepeatNote=I
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715502_543339789.0RepeatNote=II
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715544_582339789.0RepeatNote=III
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715583_619339789.0RepeatNote=IV
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816456_501339789.0RepeatNote=I
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816502_543339789.0RepeatNote=II
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816544_582339789.0RepeatNote=III
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816583_619339789.0RepeatNote=IV
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-71522_709339789.0Topological domainExtracellular
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715731_788339789.0Topological domainCytoplasmic
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-81622_709339789.0Topological domainExtracellular
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816731_788339789.0Topological domainCytoplasmic
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715710_730339789.0TransmembraneHelical
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816710_730339789.0TransmembraneHelical
TgeneSH3PXD2Bchr2:161025723chr5:171849500ENST000003116010135_12925912.0DomainPX


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Fusion Gene Sequence for ITGB6-SH3PXD2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40574_40574_1_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000283249_SH3PXD2B_chr5_171849500_ENST00000311601_length(transcript)=8786nt_BP=1255nt
TTGAAGTTGCTTTTAAACACAGCTTTTCTGCTTTACCTGTCCAGGTAGCCTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTA
TATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAATGTTATACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTC
TTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAGCAAGAACTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCT
ATTTCTAGGAAGGAATGATCACGTACAAGGTGGCTGTGCCCTGGGAGGTGCAGAAACCTGTGAAGACTGCCTGCTTATTGGACCTCAGTG
TGCCTGGTGTGCTCAGGAGAATTTTACTCATCCATCTGGAGTTGGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCA
ATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAATACTTAAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACAT
TGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAGACCAGGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTA
CCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTCCATGGATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAA
AGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTTCGGATCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGA
AGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTGTTTACCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGA
AAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGCTAATATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGT
GTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCACCTCCTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAA
ACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCACTTGGACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAAC
AATTGGACAACTCATTGATAAACTGGTACAAAACAACGTGTTATTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTA
CATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGA
CAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACAT
CCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGA
GGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAAC
CTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCA
GGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGA
AGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCA
GGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGA
AGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGC
CCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGG
CCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGG
CCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCAT
CAGCTTCCAGGCAGGCCTGAAGGTCGAGGTGATCGAGAAAAACTTGAGTGGCTGGTGGTACATTCAGATTGAAGATAAGGAAGGGTGGGC
CCCGGCCACCTTCATTGACAAGTACAAGAAGACGAGCAACGCGTCGAGACCCAACTTTCTGGCTCCCCTGCCCCACGAGGTGACCCAGCT
CCGGCTGGGGGAAGCAGCAGCGCTGGAGAACAACACGGGCAGCGAAGCCACGGGCCCCTCCCGGCCCCTGCCTGACGCACCGCATGGTGT
CATGGACTCGGGGTTGCCATGGTCTAAAGACTGGAAGGGCAGTAAGGATGTCCTGAGGAAGGCATCTTCAGACATGTCTGCGTCAGCAGG
CTACGAGGAGATCTCAGACCCCGACATGGAGGAGAAGCCCAGCCTCCCTCCGCGGAAAGAATCCATCATCAAGTCGGAGGGGGAGCTGCT
GGAGCGGGAGCGGGAGCGGCAGAGGACGGAGCAGCTCCGGGGCCCCACTCCCAAGCCTCCGGGCGTGATTTTGCCGATGATGCCAGCCAA
ACACATCCCTCCAGCCCGGGACAGCAGGAGGCCAGAGCCCAAACCTGACAAAAGCAGACTGTTCCAGCTGAAAAATGACATGGGGCTGGA
GTGTGGCCACAAGGTCTTGGCCAAGGAAGTGAAGAAGCCCAACCTCCGGCCCATCTCCAAATCCAAAACTGACCTGCCAGAGGAGAAGCC
AGATGCCACTCCCCAGAATCCCTTCTTGAAGTCCAGACCTCAGGTTAGGCCAAAACCAGCTCCTTCCCCCAAAACGGAGCCACCTCAGGG
CGAAGACCAAGTCGACATCTGCAACCTCAGGAGTAAGCTCAGGCCTGCCAAGTCCCAAGACAAGTCCTTGTTGGATGGGGAGGGCCCCCA
GGCAGTAGGGGGCCAAGACGTGGCCTTCAGCCGAAGCTTCCTCCCAGGAGAGGGGCCTGGCCGCGCCCAGGACAGGACGGGCAAACAGGA
TGGTCTCAGCCCAAAAGAGATTTCCTGCAGAGCCCCTCCGAGGCCAGCCAAGACCACAGATCCTGTGTCTAAGAGCGTGCCTGTTCCTCT
CCAAGAGGCTCCCCAGCAGAGACCTGTGGTCCCACCCCGCAGACCACCTCCCCCAAAGAAAACCTCTTCGTCATCCAGGCCGCTCCCAGA
GGTCAGAGGTCCACAGTGTGAAGGCCACGAAAGCAGGGCAGCTCCCACCCCAGGCCGTGCTCTCCTCGTCCCTCCAAAAGCCAAACCTTT
TCTCTCCAACTCTTTGGGGGGCCAGGATGACACGCGAGGCAAAGGCAGCCTGGGGCCATGGGGGACCGGCAAGATTGGAGAAAACAGGGA
GAAAGCAGCTGCAGCCTCTGTCCCCAATGCCGACGGCCTGAAGGACTCTTTGTATGTGGCCGTGGCCGACTTTGAAGGAGACAAAGACAC
CAGCAGCTTCCAGGAAGGGACAGTGTTTGAAGTCCGGGAGAAGAACAGCAGTGGCTGGTGGTTCTGCCAGGTCCTGAGCGGAGCCCCTTC
CTGGGAAGGGTGGATTCCTTCCAACTATCTCAGAAAGAAGCCGTAGCCGACTCCCTTTCTGCCTAGAGGGCCCGCTGGTCCTTGCTGGCT
TTACCCACGTATTTAATACGCCTCTTAATTTATCATTCTCCACGCAGCTTCCAAGGCAGACAGACTCTGGGGTACTGTGACTTCTTGCCT
CCCATGGGTGGAGAGTGAGTTTCGGACACCTCGGGCGCCCCTGGGCCTGATCCCTCCTATCACAGCATCACTGGAGGCTCAGAACCCACA
GCCTTTGCTTTCTGTCCATGTCAGCATCCCTGCCTTAAGAGAACTCCTCCTGGCCAATGGCATTGCCACCCAGCAGTGGGACCAAGACTC
TCCAAGACCTCCAGGACTGGATCCCATTGCCTGGAGAAACTCCAGCAAGGGTCTCTCATGGCTTGGACATGGCACAGTAAGGGGCAGCCA
ACCCAGTCCATGATGACTTTTGCTCCAACTTCTTCATGTTTCTAAAAGCCCAGTGGCTTTATTCACTCCTCCTAAATTGCCTGCTACCAG
AAGGAACTTCATCCTGAAGAAATGCATTCCATTACCAGTTCCAGGGAAAGTGTCCCCTTCCCCAAAGCCTCAGGCCCGTGGGCCTCTGAG
GTTCCACTGGATGCGGCTCCCCCAGGAGTGGGCCTGGAGATCCGCTCAGCCGCCCTGCCTCCCACCTTCTATCTTGGGACCGTGGTCAGC
CCTGAAGGGTGGTTCCAGCCCCGCGTATGCTGCGCTTTGCTGCTGCAGGCTCCGGTCCCTCCAGGGCTTTTCAATGAGAGTTCCCACCCC
AACTTGGAGCATTTCATTTTTGCCTACCTAAAGCAAGAATCTCAAAGTTTGTTTGAATAAGAGGCCCATTCACAAGTCGTGCCCTTGTGA
GCACCCCTTTGCTGAGTGCCTCGTGGGTGCCAAACACTGTACTTGGCGCTTTGCATTCATGCTTTGACCCTCACAACCTCCCTTTATAGA
TGAGGAAATTCACGCTCCATGTGCCCAAGGACACACCAGCCAGGAGGAAGAGGGAAGAGGATTTGAGTCCAGGCCTGCCTGACTTCAGTG
CCTGTGCCCTCCCCTCTGTAAAAGACAAACCAGGCAGGGAAGAGATAGAAGCTGGCTAAGTGGTGGCCAAGTGGCTTCATTGTGAGGGGG
GTGAGGGGGCATTCGTGGCTGCTCCCACACCCACCATCCCTCCAGCCCACAGCAGCCTATACCAAAGGCTGCCCTGGACTCAACAGCTGC
ATCTCCATGACAGGAGAATGCCAGGGTCCTGGTGGTTGACACAGAGCCCTGTTCCCTCTTCTAAGCTGTTGCCCCCTGGGGAATAGAGCT
TATGGAGCAACGGGAGCTGAGGTGGCCTCGAGGGCCAGCCTGGAGGGCTCTGAGCATAGCATGCAGCGGTCCCATAGGGAGGCAGGTAAC
CAAGGGCCAGGCAGAGCTGCTTCCTGTGCCTCTCCGGCATTTGTAATGTTTTTTTCTTTTTTCACGCACTGCCAAATCTGTTTTCTCCCT
TGAAGAAACCCAGGGCAGATGTGGTCATCTGTCAAACTGAGGTCTGGAGAGGCATGACTAAATCACTGCAGAAGCAAAATCAGGACCCAG
CATTTCTAGCTCCCAGCCCAGAGTAAGAGAGCAGAGCAGAACCCCTTCCCATTCTACCCGACCGAGGCAGCCCTGCCCTGCCCTGCCCCG
CCCCTCCCCACCCTGCCCTGCCCCAGAGATCTCCAGTTCACAGTGTTCATCAGGCGAGATACTTTTGGACCCACAAAGCCAGTTTTTTGG
GGGGATGCTCAGTGTCTACCTGCAGTGCCAAAGTTTTGCTTGAACAGCCCTCTTCTGCCGCGCCTCCCAGCTCCACCCCCTATCACGTGG
GTGCTGGCTGCTTCTGCGTGAGGAGCTTCCTCTGATCACCTGTAGCATCTTTAGTGCCTTCGTCCAGTCGGCCTGCAAATCCCATTTCCC
AGAGAGGCTTGGGCAGGGCCCACTTGCCACTTGGCCCTGTGCCCAGAGCGTTGGGGGCAGATGGCAGCCAGGGGAAGAAGGGAGGTGGGG
AAGGGCCGCCACCGCTTGAGGGTCCCCTCCCTTGAGAGGAGGCCCCATGGCAGTTTTCCTGAGTTCTTGATCCACTTTGGTTTAAACAAC
TTTTGTGAAGCTATGTGAGATTTGACTGCATTTCAAAAGACAAAACACATGTTTTTTTCTGATTTGCTCTTTGCCTTTCAGCGACGCTTT
CAGATACTTTGTGAGTGTCTACTCTGTGCTAGGTGCTGAGTAGACTGGGATGTGTGTGGCTCCATCCCTGGCTGGAAGAGCTTTGAGTCC
TGTCTGCTGACTTCACTGAAGGAGTTTCTCTCTTGCTTCATTCCTTCCTCCCGGGGGTCAGCTGGGTAGGAGCAGACTTGCCCTGCCTTC
CTCTAGGCAGAAAGTTTTCCTGCAAATGAAAGAATCTGCCATTCTCTTTTGCTATGATGATGATGATTATTCTGACATGACCCGCGGGTA
CTGAAGCCACAGTCCTCTCTGTTCACTGTTCTCTCCTTGAGTCATATCTATGGCCTGAGGACGTCTGTATCCAGCTCCTTTTCCTACAAT
GGTAGACACTTCCCCAGGCAGTGGGTGGGTCAGGGTGGCCAGTCACTCTCCTAGCTGTCCTTGCCTGGGGACTTAGATTTACCCCATCCA
GGACTGTGGTCGCTATTCTGTGAGCGATTGATGGCGCATATGCAGAACTCCCCTGGAGTCATGGCTCTAGAAAGTGTCCAGGCCCATCGT
GACAATGGTGCCAAGCACCGGGCTGGTGACCAGTGCCTAAACACACACGCTCCTTTAATCCTTACGGCAAGCCTGTGAGGCGGATAGGAC
CAGCCCTGATCTATAGTGAGAAAATTAAGGTTCAGAGGGAGAAGGTCCAAATAGTGGCCAAGCTGGGACTGAGATCTCGAGTTTGGGTTT
GTTTGGTTTTGTTGTTGTTGTTCTTTCCCTCGTGTCCATGACTTTTCTCTGCCATTAGCAGGGAAGTGTGCGGAGGGCTTCCAGGGAATC
AAGTGACCCTCCCTCTGAATTTCGGTGCCTCTTCCCCCCGCCCCTTGCTCACACATTTCAGTAGGTCACAGGCCAAATGGCAGCCCAAAA
GGTGGGCAGAGATTTTTTTTTCTTCCCCTCACCCCTGCTTATTAACACAATTGTGACAACTACTTTACCTTACATCCCAGGGCAAACGGA
CAGCTTGCGGTACCTCCAAAAATTTGGAAAACCCTGAGTCTAAGACCACCTCTTGATAAAAGAGGCCTTTGCTCACATGTTCTGCTCGGA
ATCTTTCTTTGCCATTGGTGGGTGTATGTCGTCCCAGCTGAGACTGCGGGAGAGCTGAGCTCCAGCTTAAACCGCTTTTAATGGCCCTTC
CCTACTGGGGGATCGCTGGAGCCCATGCCAGGTTACGGTAGTCATTTTAAACCTCTGCCACAAGGCCACGCCATAGAATCAATTTCCAAG
TCAATGTTCTTGGCCCTAAAATGTTTGCGCCCACTGAGGATTTCATTACCAGGTGGAAGATGGGGGAACATATGCCACGTTAAAGAGCAA
GTGCTGAGTGTGCCAGGACTTGAGAAGGACCTTAGGCTGAGGAGTGGACAGTCTGGTATTTATTTCGCCTCTCCCAAGTACCCAGCACAG
AGTGGGAAAAAGAAGAAACTGCTCCTGCCTTCCAGTAGCTGGCAACTTGACATCAAGAACAAAAACATTCGTAGCTGGACCCCCGTCCTT
TCATCGTGCCCAAGTCTTACATGTTGGCTTAAGCTGCCCCCTTGGAGGCCGTACCTTTCTCTTTGGACTGTGACAGTGGACACCTAACAG
CCTGAGCCATGTGTGGCTGTCTTATCCCCCAAGGGTTGTCCAGGCCCGTTCTGCAGGGCTGTTGTGTAGACTGCAGACATCCATACCTCA
CCACAGACCAAAGATGACCTCGTGTCAGACTGTGGGCTGATGAGAGGTAGAGCAGCATGCATCGAGGCCTGAGGGTGCAGGGCGCCCTCT
CTTGGCCTGGAGGAATTGCTCCTAACTAGAGTAAGTTTCCACGAGGGTCCCAGGCAGAGCTGCAGAGCTGGAACCGGAGGCTCCACAGTC
CTTGCCTGCTCATGGACCTCCTTCAGAGCACCTTTCTACAGACTGGACTGCCCAGCTCCGTGGGGTGGCATCTGGTTTCTGGTGCTATTC
TGCCAAGTTATCGAGCTCCTCCTCATGTTTCAACATTCCATCTTCCCGTTTCTATCCTCGACTCCAAAGTAAGCCTTCTTAGCTCCAATC
AGGGATGAGGGGCTCAACCTCTTCTGTCCTCAAAGAGGCCAAACGCAGTGCCACAGTCGGTAGCCTTCACTTTTAGATGTCCTATTCATG
TAAAAAAGAAGGTGCCCCCACCAGGCTTACATCAGCAATAAGCAATTCTAATGCAACGATGGTGTCCACATTTTACCCCAGTGTGTGCCC
ATGTATGCCTTTGTGCCCGTGTAATTATTGTTAGCGCCCCTTTCACTTAGAGGGGTGATGATAAACTGTGGCCACCTTGATTACAACCCA
CATTTCCTGCTTTGGGGAGCTTCCAAGTAACAGGCCATTTCTTACCTCCCTCCAGGAACAGTGGGCACTGCCCACCACCTCGTGTCTGCT
CATAGGATGACGCTGGAGATCCCCACACTTACTCTACCCTCTTGGCAAATTGGCATTCCGGTGGTGGTTTTTGTTTCCTTTAACACATTA
AATAAATGAGTATATAGGATGTGAGGGGAGGGGTGAGAACAACTAGCTGTAGCATGTGTAGGCTATATACTTTACCATTTGACTTCTTTC

>40574_40574_1_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000283249_SH3PXD2B_chr5_171849500_ENST00000311601_length(amino acids)=1228AA_BP=342
MKRMGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKN
KPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSF
VEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLV
FVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYR
RYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPK
EEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEE
EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGRE
KELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLS
GWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKD
VLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPD
KSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPA
KSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPP
PPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDS

--------------------------------------------------------------
>40574_40574_2_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000283249_SH3PXD2B_chr5_171849500_ENST00000519643_length(transcript)=2568nt_BP=1255nt
TTGAAGTTGCTTTTAAACACAGCTTTTCTGCTTTACCTGTCCAGGTAGCCTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTA
TATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAATGTTATACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTC
TTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAGCAAGAACTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCT
ATTTCTAGGAAGGAATGATCACGTACAAGGTGGCTGTGCCCTGGGAGGTGCAGAAACCTGTGAAGACTGCCTGCTTATTGGACCTCAGTG
TGCCTGGTGTGCTCAGGAGAATTTTACTCATCCATCTGGAGTTGGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCA
ATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAATACTTAAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACAT
TGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAGACCAGGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTA
CCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTCCATGGATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAA
AGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTTCGGATCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGA
AGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTGTTTACCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGA
AAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGCTAATATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGT
GTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCACCTCCTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAA
ACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCACTTGGACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAAC
AATTGGACAACTCATTGATAAACTGGTACAAAACAACGTGTTATTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTA
CATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGA
CAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACAT
CCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGA
GGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAAC
CTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCA
GGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGA
AGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCA
GGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGA
AGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGC
CCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGG
CCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGG
CCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCAT
CAGCTTCCAGGCAGGCCTGAAGGTCGAGGATCATAAGAATGTTCACTTGGAGAGCCCTGTGGAAGTCCCTCTTAGAAGAATCAAGATGCG
GACAGCACTTGGGAAGCACGTGGCAGCTTCCATGGAGATGTGAGAACCACGTCATGTCCTTGCTGCTGTGAACATGAATTTGCTAAACTG

>40574_40574_2_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000283249_SH3PXD2B_chr5_171849500_ENST00000519643_length(amino acids)=747AA_BP=342
MKRMGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKN
KPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSF
VEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLV
FVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYR
RYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPK
EEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEE
EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGRE
KELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHL

--------------------------------------------------------------
>40574_40574_3_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000409967_SH3PXD2B_chr5_171849500_ENST00000311601_length(transcript)=8743nt_BP=1212nt
GGTAGCCTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTATATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAA
TGTTATACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTCTTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAG
CAAGAACTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCTATTTCTAGGAAGGAATGATCACGTACAAGGTGGCTGTGCCCTG
GGAGGTGCAGAAACCTGTGAAGACTGCCTGCTTATTGGACCTCAGTGTGCCTGGTGTGCTCAGGAGAATTTTACTCATCCATCTGGAGTT
GGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCAATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAATACTT
AAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACATTGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAGACCA
GGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTACCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTCCATG
GATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAAAGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTTCGGA
TCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGAAGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTGTTTA
CCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGAAAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGCTAAT
ATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGTGTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCACCTC
CTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAAACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCACTTG
GACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAACAATTGGACAACTCATTGATAAACTGGTACAAAACAACGTGTTA
TTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATT
TACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGG
ATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATAC
TGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCC
CCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCC
AACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTC
GTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAA
GAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATC
CAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAG
CCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGC
AGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAG
ATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAA
GAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGTGATCGAGAAAAAC
TTGAGTGGCTGGTGGTACATTCAGATTGAAGATAAGGAAGGGTGGGCCCCGGCCACCTTCATTGACAAGTACAAGAAGACGAGCAACGCG
TCGAGACCCAACTTTCTGGCTCCCCTGCCCCACGAGGTGACCCAGCTCCGGCTGGGGGAAGCAGCAGCGCTGGAGAACAACACGGGCAGC
GAAGCCACGGGCCCCTCCCGGCCCCTGCCTGACGCACCGCATGGTGTCATGGACTCGGGGTTGCCATGGTCTAAAGACTGGAAGGGCAGT
AAGGATGTCCTGAGGAAGGCATCTTCAGACATGTCTGCGTCAGCAGGCTACGAGGAGATCTCAGACCCCGACATGGAGGAGAAGCCCAGC
CTCCCTCCGCGGAAAGAATCCATCATCAAGTCGGAGGGGGAGCTGCTGGAGCGGGAGCGGGAGCGGCAGAGGACGGAGCAGCTCCGGGGC
CCCACTCCCAAGCCTCCGGGCGTGATTTTGCCGATGATGCCAGCCAAACACATCCCTCCAGCCCGGGACAGCAGGAGGCCAGAGCCCAAA
CCTGACAAAAGCAGACTGTTCCAGCTGAAAAATGACATGGGGCTGGAGTGTGGCCACAAGGTCTTGGCCAAGGAAGTGAAGAAGCCCAAC
CTCCGGCCCATCTCCAAATCCAAAACTGACCTGCCAGAGGAGAAGCCAGATGCCACTCCCCAGAATCCCTTCTTGAAGTCCAGACCTCAG
GTTAGGCCAAAACCAGCTCCTTCCCCCAAAACGGAGCCACCTCAGGGCGAAGACCAAGTCGACATCTGCAACCTCAGGAGTAAGCTCAGG
CCTGCCAAGTCCCAAGACAAGTCCTTGTTGGATGGGGAGGGCCCCCAGGCAGTAGGGGGCCAAGACGTGGCCTTCAGCCGAAGCTTCCTC
CCAGGAGAGGGGCCTGGCCGCGCCCAGGACAGGACGGGCAAACAGGATGGTCTCAGCCCAAAAGAGATTTCCTGCAGAGCCCCTCCGAGG
CCAGCCAAGACCACAGATCCTGTGTCTAAGAGCGTGCCTGTTCCTCTCCAAGAGGCTCCCCAGCAGAGACCTGTGGTCCCACCCCGCAGA
CCACCTCCCCCAAAGAAAACCTCTTCGTCATCCAGGCCGCTCCCAGAGGTCAGAGGTCCACAGTGTGAAGGCCACGAAAGCAGGGCAGCT
CCCACCCCAGGCCGTGCTCTCCTCGTCCCTCCAAAAGCCAAACCTTTTCTCTCCAACTCTTTGGGGGGCCAGGATGACACGCGAGGCAAA
GGCAGCCTGGGGCCATGGGGGACCGGCAAGATTGGAGAAAACAGGGAGAAAGCAGCTGCAGCCTCTGTCCCCAATGCCGACGGCCTGAAG
GACTCTTTGTATGTGGCCGTGGCCGACTTTGAAGGAGACAAAGACACCAGCAGCTTCCAGGAAGGGACAGTGTTTGAAGTCCGGGAGAAG
AACAGCAGTGGCTGGTGGTTCTGCCAGGTCCTGAGCGGAGCCCCTTCCTGGGAAGGGTGGATTCCTTCCAACTATCTCAGAAAGAAGCCG
TAGCCGACTCCCTTTCTGCCTAGAGGGCCCGCTGGTCCTTGCTGGCTTTACCCACGTATTTAATACGCCTCTTAATTTATCATTCTCCAC
GCAGCTTCCAAGGCAGACAGACTCTGGGGTACTGTGACTTCTTGCCTCCCATGGGTGGAGAGTGAGTTTCGGACACCTCGGGCGCCCCTG
GGCCTGATCCCTCCTATCACAGCATCACTGGAGGCTCAGAACCCACAGCCTTTGCTTTCTGTCCATGTCAGCATCCCTGCCTTAAGAGAA
CTCCTCCTGGCCAATGGCATTGCCACCCAGCAGTGGGACCAAGACTCTCCAAGACCTCCAGGACTGGATCCCATTGCCTGGAGAAACTCC
AGCAAGGGTCTCTCATGGCTTGGACATGGCACAGTAAGGGGCAGCCAACCCAGTCCATGATGACTTTTGCTCCAACTTCTTCATGTTTCT
AAAAGCCCAGTGGCTTTATTCACTCCTCCTAAATTGCCTGCTACCAGAAGGAACTTCATCCTGAAGAAATGCATTCCATTACCAGTTCCA
GGGAAAGTGTCCCCTTCCCCAAAGCCTCAGGCCCGTGGGCCTCTGAGGTTCCACTGGATGCGGCTCCCCCAGGAGTGGGCCTGGAGATCC
GCTCAGCCGCCCTGCCTCCCACCTTCTATCTTGGGACCGTGGTCAGCCCTGAAGGGTGGTTCCAGCCCCGCGTATGCTGCGCTTTGCTGC
TGCAGGCTCCGGTCCCTCCAGGGCTTTTCAATGAGAGTTCCCACCCCAACTTGGAGCATTTCATTTTTGCCTACCTAAAGCAAGAATCTC
AAAGTTTGTTTGAATAAGAGGCCCATTCACAAGTCGTGCCCTTGTGAGCACCCCTTTGCTGAGTGCCTCGTGGGTGCCAAACACTGTACT
TGGCGCTTTGCATTCATGCTTTGACCCTCACAACCTCCCTTTATAGATGAGGAAATTCACGCTCCATGTGCCCAAGGACACACCAGCCAG
GAGGAAGAGGGAAGAGGATTTGAGTCCAGGCCTGCCTGACTTCAGTGCCTGTGCCCTCCCCTCTGTAAAAGACAAACCAGGCAGGGAAGA
GATAGAAGCTGGCTAAGTGGTGGCCAAGTGGCTTCATTGTGAGGGGGGTGAGGGGGCATTCGTGGCTGCTCCCACACCCACCATCCCTCC
AGCCCACAGCAGCCTATACCAAAGGCTGCCCTGGACTCAACAGCTGCATCTCCATGACAGGAGAATGCCAGGGTCCTGGTGGTTGACACA
GAGCCCTGTTCCCTCTTCTAAGCTGTTGCCCCCTGGGGAATAGAGCTTATGGAGCAACGGGAGCTGAGGTGGCCTCGAGGGCCAGCCTGG
AGGGCTCTGAGCATAGCATGCAGCGGTCCCATAGGGAGGCAGGTAACCAAGGGCCAGGCAGAGCTGCTTCCTGTGCCTCTCCGGCATTTG
TAATGTTTTTTTCTTTTTTCACGCACTGCCAAATCTGTTTTCTCCCTTGAAGAAACCCAGGGCAGATGTGGTCATCTGTCAAACTGAGGT
CTGGAGAGGCATGACTAAATCACTGCAGAAGCAAAATCAGGACCCAGCATTTCTAGCTCCCAGCCCAGAGTAAGAGAGCAGAGCAGAACC
CCTTCCCATTCTACCCGACCGAGGCAGCCCTGCCCTGCCCTGCCCCGCCCCTCCCCACCCTGCCCTGCCCCAGAGATCTCCAGTTCACAG
TGTTCATCAGGCGAGATACTTTTGGACCCACAAAGCCAGTTTTTTGGGGGGATGCTCAGTGTCTACCTGCAGTGCCAAAGTTTTGCTTGA
ACAGCCCTCTTCTGCCGCGCCTCCCAGCTCCACCCCCTATCACGTGGGTGCTGGCTGCTTCTGCGTGAGGAGCTTCCTCTGATCACCTGT
AGCATCTTTAGTGCCTTCGTCCAGTCGGCCTGCAAATCCCATTTCCCAGAGAGGCTTGGGCAGGGCCCACTTGCCACTTGGCCCTGTGCC
CAGAGCGTTGGGGGCAGATGGCAGCCAGGGGAAGAAGGGAGGTGGGGAAGGGCCGCCACCGCTTGAGGGTCCCCTCCCTTGAGAGGAGGC
CCCATGGCAGTTTTCCTGAGTTCTTGATCCACTTTGGTTTAAACAACTTTTGTGAAGCTATGTGAGATTTGACTGCATTTCAAAAGACAA
AACACATGTTTTTTTCTGATTTGCTCTTTGCCTTTCAGCGACGCTTTCAGATACTTTGTGAGTGTCTACTCTGTGCTAGGTGCTGAGTAG
ACTGGGATGTGTGTGGCTCCATCCCTGGCTGGAAGAGCTTTGAGTCCTGTCTGCTGACTTCACTGAAGGAGTTTCTCTCTTGCTTCATTC
CTTCCTCCCGGGGGTCAGCTGGGTAGGAGCAGACTTGCCCTGCCTTCCTCTAGGCAGAAAGTTTTCCTGCAAATGAAAGAATCTGCCATT
CTCTTTTGCTATGATGATGATGATTATTCTGACATGACCCGCGGGTACTGAAGCCACAGTCCTCTCTGTTCACTGTTCTCTCCTTGAGTC
ATATCTATGGCCTGAGGACGTCTGTATCCAGCTCCTTTTCCTACAATGGTAGACACTTCCCCAGGCAGTGGGTGGGTCAGGGTGGCCAGT
CACTCTCCTAGCTGTCCTTGCCTGGGGACTTAGATTTACCCCATCCAGGACTGTGGTCGCTATTCTGTGAGCGATTGATGGCGCATATGC
AGAACTCCCCTGGAGTCATGGCTCTAGAAAGTGTCCAGGCCCATCGTGACAATGGTGCCAAGCACCGGGCTGGTGACCAGTGCCTAAACA
CACACGCTCCTTTAATCCTTACGGCAAGCCTGTGAGGCGGATAGGACCAGCCCTGATCTATAGTGAGAAAATTAAGGTTCAGAGGGAGAA
GGTCCAAATAGTGGCCAAGCTGGGACTGAGATCTCGAGTTTGGGTTTGTTTGGTTTTGTTGTTGTTGTTCTTTCCCTCGTGTCCATGACT
TTTCTCTGCCATTAGCAGGGAAGTGTGCGGAGGGCTTCCAGGGAATCAAGTGACCCTCCCTCTGAATTTCGGTGCCTCTTCCCCCCGCCC
CTTGCTCACACATTTCAGTAGGTCACAGGCCAAATGGCAGCCCAAAAGGTGGGCAGAGATTTTTTTTTCTTCCCCTCACCCCTGCTTATT
AACACAATTGTGACAACTACTTTACCTTACATCCCAGGGCAAACGGACAGCTTGCGGTACCTCCAAAAATTTGGAAAACCCTGAGTCTAA
GACCACCTCTTGATAAAAGAGGCCTTTGCTCACATGTTCTGCTCGGAATCTTTCTTTGCCATTGGTGGGTGTATGTCGTCCCAGCTGAGA
CTGCGGGAGAGCTGAGCTCCAGCTTAAACCGCTTTTAATGGCCCTTCCCTACTGGGGGATCGCTGGAGCCCATGCCAGGTTACGGTAGTC
ATTTTAAACCTCTGCCACAAGGCCACGCCATAGAATCAATTTCCAAGTCAATGTTCTTGGCCCTAAAATGTTTGCGCCCACTGAGGATTT
CATTACCAGGTGGAAGATGGGGGAACATATGCCACGTTAAAGAGCAAGTGCTGAGTGTGCCAGGACTTGAGAAGGACCTTAGGCTGAGGA
GTGGACAGTCTGGTATTTATTTCGCCTCTCCCAAGTACCCAGCACAGAGTGGGAAAAAGAAGAAACTGCTCCTGCCTTCCAGTAGCTGGC
AACTTGACATCAAGAACAAAAACATTCGTAGCTGGACCCCCGTCCTTTCATCGTGCCCAAGTCTTACATGTTGGCTTAAGCTGCCCCCTT
GGAGGCCGTACCTTTCTCTTTGGACTGTGACAGTGGACACCTAACAGCCTGAGCCATGTGTGGCTGTCTTATCCCCCAAGGGTTGTCCAG
GCCCGTTCTGCAGGGCTGTTGTGTAGACTGCAGACATCCATACCTCACCACAGACCAAAGATGACCTCGTGTCAGACTGTGGGCTGATGA
GAGGTAGAGCAGCATGCATCGAGGCCTGAGGGTGCAGGGCGCCCTCTCTTGGCCTGGAGGAATTGCTCCTAACTAGAGTAAGTTTCCACG
AGGGTCCCAGGCAGAGCTGCAGAGCTGGAACCGGAGGCTCCACAGTCCTTGCCTGCTCATGGACCTCCTTCAGAGCACCTTTCTACAGAC
TGGACTGCCCAGCTCCGTGGGGTGGCATCTGGTTTCTGGTGCTATTCTGCCAAGTTATCGAGCTCCTCCTCATGTTTCAACATTCCATCT
TCCCGTTTCTATCCTCGACTCCAAAGTAAGCCTTCTTAGCTCCAATCAGGGATGAGGGGCTCAACCTCTTCTGTCCTCAAAGAGGCCAAA
CGCAGTGCCACAGTCGGTAGCCTTCACTTTTAGATGTCCTATTCATGTAAAAAAGAAGGTGCCCCCACCAGGCTTACATCAGCAATAAGC
AATTCTAATGCAACGATGGTGTCCACATTTTACCCCAGTGTGTGCCCATGTATGCCTTTGTGCCCGTGTAATTATTGTTAGCGCCCCTTT
CACTTAGAGGGGTGATGATAAACTGTGGCCACCTTGATTACAACCCACATTTCCTGCTTTGGGGAGCTTCCAAGTAACAGGCCATTTCTT
ACCTCCCTCCAGGAACAGTGGGCACTGCCCACCACCTCGTGTCTGCTCATAGGATGACGCTGGAGATCCCCACACTTACTCTACCCTCTT
GGCAAATTGGCATTCCGGTGGTGGTTTTTGTTTCCTTTAACACATTAAATAAATGAGTATATAGGATGTGAGGGGAGGGGTGAGAACAAC
TAGCTGTAGCATGTGTAGGCTATATACTTTACCATTTGACTTCTTTCCTTTTTTTTTTTTTAAATAAAAAAAGTGCTTGACTGGTTTCAA

>40574_40574_3_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000409967_SH3PXD2B_chr5_171849500_ENST00000311601_length(amino acids)=1228AA_BP=342
MKRMGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKN
KPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSF
VEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLV
FVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYR
RYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPK
EEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEE
EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGRE
KELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLS
GWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKD
VLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPD
KSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPA
KSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPP
PPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDS

--------------------------------------------------------------
>40574_40574_4_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000409967_SH3PXD2B_chr5_171849500_ENST00000519643_length(transcript)=2525nt_BP=1212nt
GGTAGCCTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTATATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAA
TGTTATACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTCTTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAG
CAAGAACTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCTATTTCTAGGAAGGAATGATCACGTACAAGGTGGCTGTGCCCTG
GGAGGTGCAGAAACCTGTGAAGACTGCCTGCTTATTGGACCTCAGTGTGCCTGGTGTGCTCAGGAGAATTTTACTCATCCATCTGGAGTT
GGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCAATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAATACTT
AAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACATTGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAGACCA
GGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTACCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTCCATG
GATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAAAGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTTCGGA
TCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGAAGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTGTTTA
CCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGAAAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGCTAAT
ATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGTGTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCACCTC
CTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAAACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCACTTG
GACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAACAATTGGACAACTCATTGATAAACTGGTACAAAACAACGTGTTA
TTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATT
TACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGG
ATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATAC
TGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCC
CCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCC
AACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTC
GTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAA
GAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATC
CAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAG
CCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGC
AGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAG
ATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAA
GAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGATCATAAGAATGTT
CACTTGGAGAGCCCTGTGGAAGTCCCTCTTAGAAGAATCAAGATGCGGACAGCACTTGGGAAGCACGTGGCAGCTTCCATGGAGATGTGA
GAACCACGTCATGTCCTTGCTGCTGTGAACATGAATTTGCTAAACTGCTTTTACTGTATTTTTTTTTGTCGTGGTAAAATATGCGTAATA

>40574_40574_4_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000409967_SH3PXD2B_chr5_171849500_ENST00000519643_length(amino acids)=747AA_BP=342
MKRMGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKN
KPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSF
VEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLV
FVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYR
RYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPK
EEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEE
EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGRE
KELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHL

--------------------------------------------------------------
>40574_40574_5_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000428609_SH3PXD2B_chr5_171849500_ENST00000311601_length(transcript)=8657nt_BP=1126nt
CTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTATATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAATGTTAT
ACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTCTTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAGCAAGAA
CTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCTATTTCTAGGAAGGAATGATCACGTACAAGAATTTTACTCATCCATCTGG
AGTTGGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCAATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAAT
ACTTAAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACATTGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAG
ACCAGGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTACCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTC
CATGGATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAAAGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTT
CGGATCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGAAGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTG
TTTACCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGAAAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGC
TAATATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGTGTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCA
CCTCCTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAAACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCA
CTTGGACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAACAATTGGACAACTCATTGATAAACTGGTACAAAACAACGT
GTTATTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGC
CATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCA
GCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGA
ATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAA
TCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGT
AGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTG
GTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCC
TGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGT
CATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGG
GGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGT
GGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACC
AAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGA
GGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGTGATCGAGAA
AAACTTGAGTGGCTGGTGGTACATTCAGATTGAAGATAAGGAAGGGTGGGCCCCGGCCACCTTCATTGACAAGTACAAGAAGACGAGCAA
CGCGTCGAGACCCAACTTTCTGGCTCCCCTGCCCCACGAGGTGACCCAGCTCCGGCTGGGGGAAGCAGCAGCGCTGGAGAACAACACGGG
CAGCGAAGCCACGGGCCCCTCCCGGCCCCTGCCTGACGCACCGCATGGTGTCATGGACTCGGGGTTGCCATGGTCTAAAGACTGGAAGGG
CAGTAAGGATGTCCTGAGGAAGGCATCTTCAGACATGTCTGCGTCAGCAGGCTACGAGGAGATCTCAGACCCCGACATGGAGGAGAAGCC
CAGCCTCCCTCCGCGGAAAGAATCCATCATCAAGTCGGAGGGGGAGCTGCTGGAGCGGGAGCGGGAGCGGCAGAGGACGGAGCAGCTCCG
GGGCCCCACTCCCAAGCCTCCGGGCGTGATTTTGCCGATGATGCCAGCCAAACACATCCCTCCAGCCCGGGACAGCAGGAGGCCAGAGCC
CAAACCTGACAAAAGCAGACTGTTCCAGCTGAAAAATGACATGGGGCTGGAGTGTGGCCACAAGGTCTTGGCCAAGGAAGTGAAGAAGCC
CAACCTCCGGCCCATCTCCAAATCCAAAACTGACCTGCCAGAGGAGAAGCCAGATGCCACTCCCCAGAATCCCTTCTTGAAGTCCAGACC
TCAGGTTAGGCCAAAACCAGCTCCTTCCCCCAAAACGGAGCCACCTCAGGGCGAAGACCAAGTCGACATCTGCAACCTCAGGAGTAAGCT
CAGGCCTGCCAAGTCCCAAGACAAGTCCTTGTTGGATGGGGAGGGCCCCCAGGCAGTAGGGGGCCAAGACGTGGCCTTCAGCCGAAGCTT
CCTCCCAGGAGAGGGGCCTGGCCGCGCCCAGGACAGGACGGGCAAACAGGATGGTCTCAGCCCAAAAGAGATTTCCTGCAGAGCCCCTCC
GAGGCCAGCCAAGACCACAGATCCTGTGTCTAAGAGCGTGCCTGTTCCTCTCCAAGAGGCTCCCCAGCAGAGACCTGTGGTCCCACCCCG
CAGACCACCTCCCCCAAAGAAAACCTCTTCGTCATCCAGGCCGCTCCCAGAGGTCAGAGGTCCACAGTGTGAAGGCCACGAAAGCAGGGC
AGCTCCCACCCCAGGCCGTGCTCTCCTCGTCCCTCCAAAAGCCAAACCTTTTCTCTCCAACTCTTTGGGGGGCCAGGATGACACGCGAGG
CAAAGGCAGCCTGGGGCCATGGGGGACCGGCAAGATTGGAGAAAACAGGGAGAAAGCAGCTGCAGCCTCTGTCCCCAATGCCGACGGCCT
GAAGGACTCTTTGTATGTGGCCGTGGCCGACTTTGAAGGAGACAAAGACACCAGCAGCTTCCAGGAAGGGACAGTGTTTGAAGTCCGGGA
GAAGAACAGCAGTGGCTGGTGGTTCTGCCAGGTCCTGAGCGGAGCCCCTTCCTGGGAAGGGTGGATTCCTTCCAACTATCTCAGAAAGAA
GCCGTAGCCGACTCCCTTTCTGCCTAGAGGGCCCGCTGGTCCTTGCTGGCTTTACCCACGTATTTAATACGCCTCTTAATTTATCATTCT
CCACGCAGCTTCCAAGGCAGACAGACTCTGGGGTACTGTGACTTCTTGCCTCCCATGGGTGGAGAGTGAGTTTCGGACACCTCGGGCGCC
CCTGGGCCTGATCCCTCCTATCACAGCATCACTGGAGGCTCAGAACCCACAGCCTTTGCTTTCTGTCCATGTCAGCATCCCTGCCTTAAG
AGAACTCCTCCTGGCCAATGGCATTGCCACCCAGCAGTGGGACCAAGACTCTCCAAGACCTCCAGGACTGGATCCCATTGCCTGGAGAAA
CTCCAGCAAGGGTCTCTCATGGCTTGGACATGGCACAGTAAGGGGCAGCCAACCCAGTCCATGATGACTTTTGCTCCAACTTCTTCATGT
TTCTAAAAGCCCAGTGGCTTTATTCACTCCTCCTAAATTGCCTGCTACCAGAAGGAACTTCATCCTGAAGAAATGCATTCCATTACCAGT
TCCAGGGAAAGTGTCCCCTTCCCCAAAGCCTCAGGCCCGTGGGCCTCTGAGGTTCCACTGGATGCGGCTCCCCCAGGAGTGGGCCTGGAG
ATCCGCTCAGCCGCCCTGCCTCCCACCTTCTATCTTGGGACCGTGGTCAGCCCTGAAGGGTGGTTCCAGCCCCGCGTATGCTGCGCTTTG
CTGCTGCAGGCTCCGGTCCCTCCAGGGCTTTTCAATGAGAGTTCCCACCCCAACTTGGAGCATTTCATTTTTGCCTACCTAAAGCAAGAA
TCTCAAAGTTTGTTTGAATAAGAGGCCCATTCACAAGTCGTGCCCTTGTGAGCACCCCTTTGCTGAGTGCCTCGTGGGTGCCAAACACTG
TACTTGGCGCTTTGCATTCATGCTTTGACCCTCACAACCTCCCTTTATAGATGAGGAAATTCACGCTCCATGTGCCCAAGGACACACCAG
CCAGGAGGAAGAGGGAAGAGGATTTGAGTCCAGGCCTGCCTGACTTCAGTGCCTGTGCCCTCCCCTCTGTAAAAGACAAACCAGGCAGGG
AAGAGATAGAAGCTGGCTAAGTGGTGGCCAAGTGGCTTCATTGTGAGGGGGGTGAGGGGGCATTCGTGGCTGCTCCCACACCCACCATCC
CTCCAGCCCACAGCAGCCTATACCAAAGGCTGCCCTGGACTCAACAGCTGCATCTCCATGACAGGAGAATGCCAGGGTCCTGGTGGTTGA
CACAGAGCCCTGTTCCCTCTTCTAAGCTGTTGCCCCCTGGGGAATAGAGCTTATGGAGCAACGGGAGCTGAGGTGGCCTCGAGGGCCAGC
CTGGAGGGCTCTGAGCATAGCATGCAGCGGTCCCATAGGGAGGCAGGTAACCAAGGGCCAGGCAGAGCTGCTTCCTGTGCCTCTCCGGCA
TTTGTAATGTTTTTTTCTTTTTTCACGCACTGCCAAATCTGTTTTCTCCCTTGAAGAAACCCAGGGCAGATGTGGTCATCTGTCAAACTG
AGGTCTGGAGAGGCATGACTAAATCACTGCAGAAGCAAAATCAGGACCCAGCATTTCTAGCTCCCAGCCCAGAGTAAGAGAGCAGAGCAG
AACCCCTTCCCATTCTACCCGACCGAGGCAGCCCTGCCCTGCCCTGCCCCGCCCCTCCCCACCCTGCCCTGCCCCAGAGATCTCCAGTTC
ACAGTGTTCATCAGGCGAGATACTTTTGGACCCACAAAGCCAGTTTTTTGGGGGGATGCTCAGTGTCTACCTGCAGTGCCAAAGTTTTGC
TTGAACAGCCCTCTTCTGCCGCGCCTCCCAGCTCCACCCCCTATCACGTGGGTGCTGGCTGCTTCTGCGTGAGGAGCTTCCTCTGATCAC
CTGTAGCATCTTTAGTGCCTTCGTCCAGTCGGCCTGCAAATCCCATTTCCCAGAGAGGCTTGGGCAGGGCCCACTTGCCACTTGGCCCTG
TGCCCAGAGCGTTGGGGGCAGATGGCAGCCAGGGGAAGAAGGGAGGTGGGGAAGGGCCGCCACCGCTTGAGGGTCCCCTCCCTTGAGAGG
AGGCCCCATGGCAGTTTTCCTGAGTTCTTGATCCACTTTGGTTTAAACAACTTTTGTGAAGCTATGTGAGATTTGACTGCATTTCAAAAG
ACAAAACACATGTTTTTTTCTGATTTGCTCTTTGCCTTTCAGCGACGCTTTCAGATACTTTGTGAGTGTCTACTCTGTGCTAGGTGCTGA
GTAGACTGGGATGTGTGTGGCTCCATCCCTGGCTGGAAGAGCTTTGAGTCCTGTCTGCTGACTTCACTGAAGGAGTTTCTCTCTTGCTTC
ATTCCTTCCTCCCGGGGGTCAGCTGGGTAGGAGCAGACTTGCCCTGCCTTCCTCTAGGCAGAAAGTTTTCCTGCAAATGAAAGAATCTGC
CATTCTCTTTTGCTATGATGATGATGATTATTCTGACATGACCCGCGGGTACTGAAGCCACAGTCCTCTCTGTTCACTGTTCTCTCCTTG
AGTCATATCTATGGCCTGAGGACGTCTGTATCCAGCTCCTTTTCCTACAATGGTAGACACTTCCCCAGGCAGTGGGTGGGTCAGGGTGGC
CAGTCACTCTCCTAGCTGTCCTTGCCTGGGGACTTAGATTTACCCCATCCAGGACTGTGGTCGCTATTCTGTGAGCGATTGATGGCGCAT
ATGCAGAACTCCCCTGGAGTCATGGCTCTAGAAAGTGTCCAGGCCCATCGTGACAATGGTGCCAAGCACCGGGCTGGTGACCAGTGCCTA
AACACACACGCTCCTTTAATCCTTACGGCAAGCCTGTGAGGCGGATAGGACCAGCCCTGATCTATAGTGAGAAAATTAAGGTTCAGAGGG
AGAAGGTCCAAATAGTGGCCAAGCTGGGACTGAGATCTCGAGTTTGGGTTTGTTTGGTTTTGTTGTTGTTGTTCTTTCCCTCGTGTCCAT
GACTTTTCTCTGCCATTAGCAGGGAAGTGTGCGGAGGGCTTCCAGGGAATCAAGTGACCCTCCCTCTGAATTTCGGTGCCTCTTCCCCCC
GCCCCTTGCTCACACATTTCAGTAGGTCACAGGCCAAATGGCAGCCCAAAAGGTGGGCAGAGATTTTTTTTTCTTCCCCTCACCCCTGCT
TATTAACACAATTGTGACAACTACTTTACCTTACATCCCAGGGCAAACGGACAGCTTGCGGTACCTCCAAAAATTTGGAAAACCCTGAGT
CTAAGACCACCTCTTGATAAAAGAGGCCTTTGCTCACATGTTCTGCTCGGAATCTTTCTTTGCCATTGGTGGGTGTATGTCGTCCCAGCT
GAGACTGCGGGAGAGCTGAGCTCCAGCTTAAACCGCTTTTAATGGCCCTTCCCTACTGGGGGATCGCTGGAGCCCATGCCAGGTTACGGT
AGTCATTTTAAACCTCTGCCACAAGGCCACGCCATAGAATCAATTTCCAAGTCAATGTTCTTGGCCCTAAAATGTTTGCGCCCACTGAGG
ATTTCATTACCAGGTGGAAGATGGGGGAACATATGCCACGTTAAAGAGCAAGTGCTGAGTGTGCCAGGACTTGAGAAGGACCTTAGGCTG
AGGAGTGGACAGTCTGGTATTTATTTCGCCTCTCCCAAGTACCCAGCACAGAGTGGGAAAAAGAAGAAACTGCTCCTGCCTTCCAGTAGC
TGGCAACTTGACATCAAGAACAAAAACATTCGTAGCTGGACCCCCGTCCTTTCATCGTGCCCAAGTCTTACATGTTGGCTTAAGCTGCCC
CCTTGGAGGCCGTACCTTTCTCTTTGGACTGTGACAGTGGACACCTAACAGCCTGAGCCATGTGTGGCTGTCTTATCCCCCAAGGGTTGT
CCAGGCCCGTTCTGCAGGGCTGTTGTGTAGACTGCAGACATCCATACCTCACCACAGACCAAAGATGACCTCGTGTCAGACTGTGGGCTG
ATGAGAGGTAGAGCAGCATGCATCGAGGCCTGAGGGTGCAGGGCGCCCTCTCTTGGCCTGGAGGAATTGCTCCTAACTAGAGTAAGTTTC
CACGAGGGTCCCAGGCAGAGCTGCAGAGCTGGAACCGGAGGCTCCACAGTCCTTGCCTGCTCATGGACCTCCTTCAGAGCACCTTTCTAC
AGACTGGACTGCCCAGCTCCGTGGGGTGGCATCTGGTTTCTGGTGCTATTCTGCCAAGTTATCGAGCTCCTCCTCATGTTTCAACATTCC
ATCTTCCCGTTTCTATCCTCGACTCCAAAGTAAGCCTTCTTAGCTCCAATCAGGGATGAGGGGCTCAACCTCTTCTGTCCTCAAAGAGGC
CAAACGCAGTGCCACAGTCGGTAGCCTTCACTTTTAGATGTCCTATTCATGTAAAAAAGAAGGTGCCCCCACCAGGCTTACATCAGCAAT
AAGCAATTCTAATGCAACGATGGTGTCCACATTTTACCCCAGTGTGTGCCCATGTATGCCTTTGTGCCCGTGTAATTATTGTTAGCGCCC
CTTTCACTTAGAGGGGTGATGATAAACTGTGGCCACCTTGATTACAACCCACATTTCCTGCTTTGGGGAGCTTCCAAGTAACAGGCCATT
TCTTACCTCCCTCCAGGAACAGTGGGCACTGCCCACCACCTCGTGTCTGCTCATAGGATGACGCTGGAGATCCCCACACTTACTCTACCC
TCTTGGCAAATTGGCATTCCGGTGGTGGTTTTTGTTTCCTTTAACACATTAAATAAATGAGTATATAGGATGTGAGGGGAGGGGTGAGAA
CAACTAGCTGTAGCATGTGTAGGCTATATACTTTACCATTTGACTTCTTTCCTTTTTTTTTTTTTAAATAAAAAAAGTGCTTGACTGGTT

>40574_40574_5_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000428609_SH3PXD2B_chr5_171849500_ENST00000311601_length(amino acids)=1183AA_BP=297
MITYKNFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYP
VDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAER
FNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTI
GQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIR
DVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQV
VDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEG
WAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGL
NLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLR
LGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLE
RERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPD
ATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDG
LSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFL
SNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSW

--------------------------------------------------------------
>40574_40574_6_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000428609_SH3PXD2B_chr5_171849500_ENST00000519643_length(transcript)=2439nt_BP=1126nt
CTCTGTTTTCATTTCAGTCTTAATGAAAACTTTCTAACTTATATCTCAAGTTTCTTTTCAAAGCAGTGTAAGTAGTATTTAAAATGTTAT
ACTTCAAGAAAGAAAGACTTTAACGATATTCAGCGTTGGTCTTGTAACGCTGAAGGTAATTCATTTTTTAATCGGTCTGCACAGCAAGAA
CTGAAACGAATGGGGATTGAACTGCTTTGCCTGTTCTTTCTATTTCTAGGAAGGAATGATCACGTACAAGAATTTTACTCATCCATCTGG
AGTTGGCGAAAGGTGTGATACCCCAGCAAACCTTTTAGCTAAAGGATGTCAATTAAACTTCATCGAAAACCCTGTCTCCCAAGTAGAAAT
ACTTAAAAATAAGCCTCTCAGTGTAGGCAGACAGAAAAATAGTTCTGACATTGTTCAGATTGCGCCTCAAAGCTTGATCCTTAAGTTGAG
ACCAGGTGGTGCGCAGACTCTGCAGGTGCATGTCCGCCAGACTGAGGACTACCCGGTGGATTTGTATTACCTCATGGACCTCTCCGCCTC
CATGGATGACGACCTCAACACAATAAAGGAGCTGGGCTCCCGGCTTTCCAAAGAGATGTCTAAATTAACCAGCAACTTTAGACTGGGCTT
CGGATCTTTTGTGGAAAAACCTGTATCCCCTTTTGTGAAAACAACACCAGAAGAAATTGCCAACCCTTGCAGTAGTATTCCATACTTCTG
TTTACCTACATTTGGATTCAAGCACATTTTGCCATTGACAAATGATGCTGAAAGATTCAATGAAATTGTGAAGAATCAGAAAATTTCTGC
TAATATTGACACACCCGAAGGTGGATTTGATGCAATTATGCAAGCTGCTGTGTGTAAGGAAAAAATTGGCTGGCGGAATGACTCCCTCCA
CCTCCTGGTCTTTGTGAGTGATGCTGATTCTCATTTTGGAATGGACAGCAAACTAGCAGGCATCGTCATTCCTAATGACGGGCTCTGTCA
CTTGGACAGCAAGAATGAATACTCCATGTCAACTGTCTTGGAATATCCAACAATTGGACAACTCATTGATAAACTGGTACAAAACAACGT
GTTATTGATCTTCGCTGTAACCCAAGAACAAGTTCATTTATATGAGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGC
CATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCA
GCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGA
ATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAA
TCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGT
AGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTG
GTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCC
TGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGT
CATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGG
GGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGT
GGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACC
AAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGA
GGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGATCATAAGAA
TGTTCACTTGGAGAGCCCTGTGGAAGTCCCTCTTAGAAGAATCAAGATGCGGACAGCACTTGGGAAGCACGTGGCAGCTTCCATGGAGAT
GTGAGAACCACGTCATGTCCTTGCTGCTGTGAACATGAATTTGCTAAACTGCTTTTACTGTATTTTTTTTTGTCGTGGTAAAATATGCGT

>40574_40574_6_ITGB6-SH3PXD2B_ITGB6_chr2_161025723_ENST00000428609_SH3PXD2B_chr5_171849500_ENST00000519643_length(amino acids)=702AA_BP=297
MITYKNFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYP
VDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAER
FNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTI
GQLIDKLVQNNVLLIFAVTQEQVHLYEVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIR
DVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQV
VDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEG
WAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGL

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Fusion Gene PPI Analysis for ITGB6-SH3PXD2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneITGB6chr2:161025723chr5:171849500ENST00000283249-715731_758339.0789.0HAX1
HgeneITGB6chr2:161025723chr5:171849500ENST00000409872-816731_758339.0789.0HAX1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGB6-SH3PXD2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGB6-SH3PXD2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource