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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ITLN1-DOCK11 (FusionGDB2 ID:40606)

Fusion Gene Summary for ITLN1-DOCK11

Fusion gene summary

Fusion gene information	Fusion gene name: ITLN1-DOCK11
	Fusion gene ID: 40606
		Hgene	Tgene
	Gene symbol	ITLN1	DOCK11
	Gene ID	55600	139818
	Gene name	intelectin 1	dedicator of cytokinesis 11
	Synonyms	HL-1\|HL1\|INTL\|ITLN\|LFR\|hIntL\|omentin	ACG\|ZIZ2\|bB128O4.1
	Cytomap	1q23.3	Xq24
	Type of gene	protein-coding	protein-coding
	Description	intelectin-1ITLN-1endothelial lectin HL-1galactofuranose-binding lectinintelectin 1 (galactofuranose binding)intestinal lactoferrin receptor	dedicator of cytokinesis protein 11Activated Cdc42-associated guanine nucleotide exchange factor, ACGbB128O4.1.1 (novel protein)zizimin-2zizimin2
	Modification date	20200313	20200313
	UniProtAcc	Q8WWA0	Q5JSL3
	Ensembl transtripts involved in fusion gene	ENST00000326245, ENST00000487531,	ENST00000276202, ENST00000276204,
Fusion gene scores	* DoF score	6 X 5 X 2=60	11 X 12 X 7=924
	# samples	6	13
	** MAII score	log2(6/60*10)=0	log2(13/924*10)=-2.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ITLN1 [Title/Abstract] AND DOCK11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ITLN1(160851748)-DOCK11(117742246), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITLN1	GO:0001934	positive regulation of protein phosphorylation	16531507
Hgene	ITLN1	GO:0046326	positive regulation of glucose import	16531507
Hgene	ITLN1	GO:0070207	protein homotrimerization	26148048

Fusion gene breakpoints across ITLN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DOCK11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-MQ-A4LC-01A	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+

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Fusion Gene ORF analysis for ITLN1-DOCK11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000326245	ENST00000276202	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+
In-frame	ENST00000326245	ENST00000276204	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+
intron-3CDS	ENST00000487531	ENST00000276202	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+
intron-3CDS	ENST00000487531	ENST00000276204	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000326245

ITLN1

chr1

160851748

ENST00000276204

DOCK11

chrX

117742246

4307

521

336

3950

1204

ENST00000326245

ITLN1

chr1

160851748

ENST00000276202

DOCK11

chrX

117742246

4279

521

336

3938

1200

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326245	ENST00000276204	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+	0.000438433	0.9995616
ENST00000326245	ENST00000276202	ITLN1	chr1	160851748	-	DOCK11	chrX	117742246	+	0.000758088	0.99924195

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Fusion Genomic Features for ITLN1-DOCK11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITLN1-DOCK11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:160851748/chrX:117742246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITLN1 Q8WWA0	DOCK11 Q5JSL3
FUNCTION: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). {ECO:0000269\|PubMed:11313366, ECO:0000269\|PubMed:16531507, ECO:0000269\|PubMed:23921499, ECO:0000269\|PubMed:26148048, ECO:0000305, ECO:0000305\|PubMed:11747454}.	FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250\|UniProtKB:A2AF47}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DOCK11

chr1:160851748

chrX:117742246

ENST00000276202

1609_2036

2074.0

Domain

DOCKER

Tgene

DOCK11

chr1:160851748

chrX:117742246

ENST00000276202

165_272

2074.0

Domain

Tgene

DOCK11

chr1:160851748

chrX:117742246

ENST00000276202

640_818

2074.0

Domain

C2 DOCK-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITLN1

chr1:160851748

chrX:117742246

ENST00000326245

32_255

135

314.0

Domain

Fibrinogen C-terminal

Hgene

ITLN1

chr1:160851748

chrX:117742246

ENST00000326245

262_263

135

314.0

Region

Carbohydrate binding

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Fusion Gene Sequence for ITLN1-DOCK11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40606_40606_1_ITLN1-DOCK11_ITLN1_chr1_160851748_ENST00000326245_DOCK11_chrX_117742246_ENST00000276202_length(transcript)=4279nt_BP=521nt
AGGAGCGTTTTTGGAGAAAGCTGCACTCTGTTGAGCTCCAGGGCGCAGTGGAGGGAGGGAGTGAAGGAGCTCTCTGTACCCAAGGAAAGT
GCAGCTGAGACTCAGACAAGATTACAATGAACCAACTCAGCTTCCTGCTGTTTCTCATAGCGACCACCAGAGGATGGAGTACAGATGAGG
CTAATACTTACTTCAAGGAATGGACCTGTTCTTCGTCTCCATCTCTGCCCAGAAGCTGCAAGGAAATCAAAGACGAATGTCCTAGTGCAT
TTGATGGCCTGTATTTTCTCCGCACTGAGAATGGTGTTATCTACCAGACCTTCTGTGACATGACCTCTGGGGGTGGCGGCTGGACCCTGG
TGGCCAGCGTGCACGAGAATGACATGCGTGGGAAGTGCACGGTGGGCGATCGCTGGTCCAGTCAGCAGGGCAGCAAAGCAGTCTACCCAG
AGGGGGACGGCAACTGGGCCAACTACAACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTACGATG
ATAGCAATATTGAAACAGTCTGCAGATTTTTTATCAATAAACAAATTGCTAAAGTACTCATGGTTTTTCTTTGAAATAATTGCAAAGTCA
ATGGCCACATACTTGTTGGAAGAGAATAAGATTAAGCTTCCCCGAGGCCAGAGATTTCCCGAGACATATCATCATGTCTTACATTCACTG
CTTCTTGCAATAATTCCCCATGTGACTATTCGGTATGCGGAGATTCCCGATGAGTCCAGAAATGTGAACTATAGTTTGGCTAGCTTCCTG
AAGCGCTGTTTGACACTAATGGATAGAGGATTTATTTTCAATTTAATAAATGACTATATATCTGGATTCAGCCCCAAAGATCCTAAGGTT
CTGGCTGAATACAAGTTTGAATTTCTGCAAACAATTTGCAATCACGAACATTACATTCCTCTGAACTTGCCAATGGCATTTGCAAAACCT
AAACTGCAGCGGGTTCAAGATTCAAATCTTGAATACAGTTTATCAGATGAGTATTGCAAGCATCACTTCTTGGTTGGTCTACTTCTGAGG
GAAACTTCCATTGCTCTTCAGGACAATTATGAGATCAGATATACAGCTATCTCTGTTATAAAGAATCTTTTGATAAAACATGCATTTGAC
ACAAGATACCAGCACAAGAACCAACAAGCCAAAATAGCACAATTGTACCTCCCCTTTGTTGGACTACTTTTGGAAAATATACAGCGATTA
GCAGGTCGAGATACCTTGTATTCTTGTGCAGCCATGCCTAATTCTGCATCCAGAGATGAGTTTCCATGTGGCTTTACTTCACCTGCCAAT
AGAGGGAGTCTGAGCACTGACAAAGACACCGCTTATGGGTCTTTTCAAAATGGACATGGAATTAAGAGAGAAGATTCAAGAGGTTCCCTC
ATCCCAGAAGGAGCAACAGGATTTCCAGATCAGGGCAACACTGGTGAAAATACCCGACAGAGTTCTACAAGGAGTAGTGTATCCCAGTAT
AACCGCCTGGATCAGTATGAAATCAGAAGCCTCCTGATGTGCTACCTGTATATAGTAAAAATGATTTCAGAAGATACTCTCTTAACTTAC
TGGAATAAAGTATCACCTCAGGAGCTCATAAACATTCTTATACTTTTAGAAGTATGCTTGTTTCACTTTAGATATATGGGGAAAAGAAAC
ATAGCAAGGGTGCATGATGCCTGGCTGTCAAAACACTTCGGAATAGACCGAAAATCGCAAACCATGCCTGCTCTTCGAAACAGATCAGGA
GTAATGCAGGCCCGGCTTCAGCATCTTAGTAGCCTAGAAAGTTCATTTACACTTAATCACAGTTCTACAACAACTGAAGCAGACATTTTC
CACCAGGCACTTCTTGAAGGCAATACAGCTACTGAAGTTTCCCTAACAGTACTAGACACCATATCATTTTTCACTCAGTGCTTCAAGACC
CAACTTTTAAATAATGATGGCCATAACCCATTAATGAAAAAAGTGTTTGATATACATCTTGCTTTTCTTAAAAATGGACAATCTGAAGTG
TCGCTGAAACATGTATTTGCCTCACTGAGAGCTTTCATCAGTAAGTTTCCTTCAGCATTTTTCAAAGGAAGAGTAAACATGTGTGCTGCA
TTTTGCTATGAGGTTTTAAAGTGCTGCACATCGAAGATTAGCTCAACCAGGAATGAAGCATCTGCACTTTTGTATCTTTTGATGAGAAAC
AACTTTGAGTATACCAAAAGGAAAACCTTTTTGAGGACACATCTACAGATAATAATTGCTGTAAGCCAACTGATAGCTGATGTAGCACTA
AGCGGAGGATCAAGATTTCAGGAGTCTTTATTCATTATCAATAATTTTGCAAATAGTGACAGACCTATGAAGGCAACTGCCTTTCCCGCA
GAAGTCAAAGACTTGACCAAGAGAATCCGCACTGTTCTTATGGCCACTGCCCAAATGAAGGAGCATGAGAAAGACCCTGAAATGCTAATT
GATCTCCAGTATAGCTTAGCCAAGTCCTATGCAAGCACCCCAGAGCTCAGGAAAACCTGGCTTGATAGCATGGCCAAGATTCATGTAAAA
AATGGAGATTTTTCAGAGGCTGCGATGTGTTATGTCCATGTAGCAGCTCTAGTTGCAGAGTTTCTTCATCGAAAAAAATTATTTCCTAAC
GGATGTTCAGCGTTCAAGAAAATTACTCCCAATATAGATGAAGAAGGAGCAATGAAAGAAGATGCTGGGATGATGGATGTCCATTATAGT
GAAGAGGTCTTGCTGGAGTTGCTAGAACAATGTGTGGATGGCTTATGGAAGGCAGAACGTTATGAAATAATTTCTGAGATTTCCAAGTTG
ATCGTTCCAATTTATGAGAAACGTCGTGAGTTTGAGAAACTTACTCAAGTTTATAGAACTCTTCATGGAGCTTACACAAAAATTCTGGAA
GTTATGCATACAAAAAAGAGACTTTTAGGCACTTTCTTCAGAGTTGCCTTTTATGGCCAATCTTTTTTTGAAGAAGAAGATGGAAAGGAG
TACATCTATAAAGAACCAAAGCTCACTGGCCTCTCAGAAATTTCCTTGAGACTTGTTAAACTTTATGGTGAAAAGTTTGGTACGGAGAAT
GTCAAAATAATTCAGGATTCAGACAAGGTAAATGCCAAAGAGCTTGATCCAAAATATGCTCATATACAAGTTACTTATGTGAAGCCTTAC
TTTGATGACAAAGAACTCACAGAAAGGAAGACCGAGTTTGAAAGAAATCATAATATCAGCAGATTTGTTTTTGAGGCCCCTTACACTTTA
TCAGGCAAAAAACAGGGCTGTATAGAAGAACAGTGCAAACGCCGTACAATCTTGACAACTTCAAACTCGTTTCCTTACGTGAAGAAGAGG
ATTCCTATTAACTGTGAACAGCAGATTAATTTAAAACCAATTGATGTTGCCACTGATGAAATAAAAGATAAAACTGCAGAGCTGCAAAAG
CTTTGCTCCTCTACTGACGTGGACATGATTCAGCTCCAACTTAAATTGCAGGGCTGTGTTTCTGTGCAGGTCAATGCTGGTCCATTAGCA
TATGCAAGAGCTTTCTTAAATGACAGCCAAGCTAGCAAGTATCCACCTAAGAAAGTGAGTGAGTTGAAAGACATGTTTAGGAAATTTATA
CAAGCATGCAGCATTGCACTTGAACTAAATGAGCGGCTAATTAAAGAAGATCAAGTTGAGTACCATGAAGGGCTAAAGTCAAATTTCAGA
GACATGGTAAAAGAATTATCTGACATTATCCATGAGCAGATATTACAAGAAGACACAATGCATTCTCCCTGGATGAGCAACACATTACAT
GTATTTTGTGCAATTAGTGGTACATCAAGTGACCGAGGTTATGGTTCCCCAAGATACGCTGAAGTGTGAGGAAATGCAGATGTACGTGAC
AATGAGACTGACCTTTCTCAGGAATATTTGGAGCTGTGCAAATGTTAAAATTTAAAGATTTGATATACATGGAGTGTTTCTTCTCGACAC
CAAAATTTTCATGTGTTCCAACAGGGTGCTTACATATTTGTAAATAAGCAACTTGAAAGTGCCTGGAAAATTGCACCACTGTGCTTGGTT
TGTACTTTTTTAGGTAAATCTATATGCTGAAAAGTAGAGCTCAAAAACAGTAGTTCAATTTGCTTAATTATTGCTTAAAATAATGGTACT

>40606_40606_1_ITLN1-DOCK11_ITLN1_chr1_160851748_ENST00000326245_DOCK11_chrX_117742246_ENST00000276202_length(amino acids)=1200AA_BP=62
MGVAAGPWWPACTRMTCVGSARWAIAGPVSRAAKQSTQRGTATGPTTTPLDLQRRPRAMTTRTLATTMIAILKQSADFLSINKLLKYSWF
FFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISG
FSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKN
LLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIK
REDSRGSLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVCLFH
FRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTIS
FFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASA
LLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEH
EKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMKEDA
GMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSF
FEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNISRF
VFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSV
QVNAGPLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHS

--------------------------------------------------------------
>40606_40606_2_ITLN1-DOCK11_ITLN1_chr1_160851748_ENST00000326245_DOCK11_chrX_117742246_ENST00000276204_length(transcript)=4307nt_BP=521nt
AGGAGCGTTTTTGGAGAAAGCTGCACTCTGTTGAGCTCCAGGGCGCAGTGGAGGGAGGGAGTGAAGGAGCTCTCTGTACCCAAGGAAAGT
GCAGCTGAGACTCAGACAAGATTACAATGAACCAACTCAGCTTCCTGCTGTTTCTCATAGCGACCACCAGAGGATGGAGTACAGATGAGG
CTAATACTTACTTCAAGGAATGGACCTGTTCTTCGTCTCCATCTCTGCCCAGAAGCTGCAAGGAAATCAAAGACGAATGTCCTAGTGCAT
TTGATGGCCTGTATTTTCTCCGCACTGAGAATGGTGTTATCTACCAGACCTTCTGTGACATGACCTCTGGGGGTGGCGGCTGGACCCTGG
TGGCCAGCGTGCACGAGAATGACATGCGTGGGAAGTGCACGGTGGGCGATCGCTGGTCCAGTCAGCAGGGCAGCAAAGCAGTCTACCCAG
AGGGGGACGGCAACTGGGCCAACTACAACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTACGATG
ATAGCAATATTGAAACAGTCTGCAGATTTTTTATCAATAAACAAATTGCTAAAGTACTCATGGTTTTTCTTTGAAATAATTGCAAAGTCA
ATGGCCACATACTTGTTGGAAGAGAATAAGATTAAGCTTCCCCGAGGCCAGAGATTTCCCGAGACATATCATCATGTCTTACATTCACTG
CTTCTTGCAATAATTCCCCATGTGACTATTCGGTATGCGGAGATTCCCGATGAGTCCAGAAATGTGAACTATAGTTTGGCTAGCTTCCTG
AAGCGCTGTTTGACACTAATGGATAGAGGATTTATTTTCAATTTAATAAATGACTATATATCTGGATTCAGCCCCAAAGATCCTAAGGTT
CTGGCTGAATACAAGTTTGAATTTCTGCAAACAATTTGCAATCACGAACATTACATTCCTCTGAACTTGCCAATGGCATTTGCAAAACCT
AAACTGCAGCGGGTTCAAGATTCAAATCTTGAATACAGTTTATCAGATGAGTATTGCAAGCATCACTTCTTGGTTGGTCTACTTCTGAGG
GAAACTTCCATTGCTCTTCAGGACAATTATGAGATCAGATATACAGCTATCTCTGTTATAAAGAATCTTTTGATAAAACATGCATTTGAC
ACAAGATACCAGCACAAGAACCAACAAGCCAAAATAGCACAATTGTACCTCCCCTTTGTTGGACTACTTTTGGAAAATATACAGCGATTA
GCAGGTCGAGATACCTTGTATTCTTGTGCAGCCATGCCTAATTCTGCATCCAGAGATGAGTTTCCATGTGGCTTTACTTCACCTGCCAAT
AGAGGGAGTCTGAGCACTGACAAAGACACCGCTTATGGGTCTTTTCAAAATGGACATGGAATTAAGAGAGAAGATTCAAGAGGTTCCCTC
ATCCCAGAAGGAGCAACAGGATTTCCAGATCAGGGCAACACTGGTGAAAATACCCGACAGAGTTCTACAAGGAGTAGTGTATCCCAGTAT
AACCGCCTGGATCAGTATGAAATCAGAAGCCTCCTGATGTGCTACCTGTATATAGTAAAAATGATTTCAGAAGATACTCTCTTAACTTAC
TGGAATAAAGTATCACCTCAGGAGCTCATAAACATTCTTATACTTTTAGAAGTATGCTTGTTTCACTTTAGATATATGGGGAAAAGAAAC
ATAGCAAGGGTGCATGATGCCTGGCTGTCAAAACACTTCGGAATAGACCGAAAATCGCAAACCATGCCTGCTCTTCGAAACAGATCAGGA
GTAATGCAGGCCCGGCTTCAGCATCTTAGTAGCCTAGAAAGTTCATTTACACTTAATCACAGTTCTACAACAACTGAAGCAGACATTTTC
CACCAGGCACTTCTTGAAGGCAATACAGCTACTGAAGTTTCCCTAACAGTACTAGACACCATATCATTTTTCACTCAGTGCTTCAAGACC
CAACTTTTAAATAATGATGGCCATAACCCATTAATGAAAAAAGTGTTTGATATACATCTTGCTTTTCTTAAAAATGGACAATCTGAAGTG
TCGCTGAAACATGTATTTGCCTCACTGAGAGCTTTCATCAGTAAGTTTCCTTCAGCATTTTTCAAAGGAAGAGTAAACATGTGTGCTGCA
TTTTGCTATGAGGTTTTAAAGTGCTGCACATCGAAGATTAGCTCAACCAGGAATGAAGCATCTGCACTTTTGTATCTTTTGATGAGAAAC
AACTTTGAGTATACCAAAAGGAAAACCTTTTTGAGGACACATCTACAGATAATAATTGCTGTAAGCCAACTGATAGCTGATGTAGCACTA
AGCGGAGGATCAAGATTTCAGGAGTCTTTATTCATTATCAATAATTTTGCAAATAGTGACAGACCTATGAAGGCAACTGCCTTTCCCGCA
GAAGTCAAAGACTTGACCAAGAGAATCCGCACTGTTCTTATGGCCACTGCCCAAATGAAGGAGCATGAGAAAGACCCTGAAATGCTAATT
GATCTCCAGTATAGCTTAGCCAAGTCCTATGCAAGCACCCCAGAGCTCAGGAAAACCTGGCTTGATAGCATGGCCAAGATTCATGTAAAA
AATGGAGATTTTTCAGAGGCTGCGATGTGTTATGTCCATGTAGCAGCTCTAGTTGCAGAGTTTCTTCATCGAAAAAAATTATTTCCTAAC
GGATGTTCAGCGTTCAAGAAAATTACTCCCAATATAGATGAAGAAGGAGCAATGAAAGAAGATGCTGGGATGATGGATGTCCATTATAGT
GAAGAGGTCTTGCTGGAGTTGCTAGAACAATGTGTGGATGGCTTATGGAAGGCAGAACGTTATGAAATAATTTCTGAGATTTCCAAGTTG
ATCGTTCCAATTTATGAGAAACGTCGTGAGTTTGAGAAACTTACTCAAGTTTATAGAACTCTTCATGGAGCTTACACAAAAATTCTGGAA
GTTATGCATACAAAAAAGAGACTTTTAGGCACTTTCTTCAGAGTTGCCTTTTATGGCCAATCTTTTTTTGAAGAAGAAGATGGAAAGGAG
TACATCTATAAAGAACCAAAGCTCACTGGCCTCTCAGAAATTTCCTTGAGACTTGTTAAACTTTATGGTGAAAAGTTTGGTACGGAGAAT
GTCAAAATAATTCAGGATTCAGACAAGGTAAATGCCAAAGAGCTTGATCCAAAATATGCTCATATACAAGTTACTTATGTGAAGCCTTAC
TTTGATGACAAAGAACTCACAGAAAGGAAGACCGAGTTTGAAAGAAATCATAATATCAGCAGATTTGTTTTTGAGGCCCCTTACACTTTA
TCAGGCAAAAAACAGGGCTGTATAGAAGAACAGTGCAAACGCCGTACAATCTTGACAACTTCAAACTCGTTTCCTTACGTGAAGAAGAGG
ATTCCTATTAACTGTGAACAGCAGATTAATTTAAAACCAATTGATGTTGCCACTGATGAAATAAAAGATAAAACTGCAGAGCTGCAAAAG
CTTTGCTCCTCTACTGACGTGGACATGATTCAGCTCCAACTTAAATTGCAGGGCTGTGTTTCTGTGCAGGTCAATGCTGGTCCATTAGCA
TATGCAAGAGCTTTCTTAAATGACAGCCAAGCTAGCAAGTATCCACCTAAGAAAGTGAGTGAGTTGAAAGACATGTTTAGGAAATTTATA
CAAGCATGCAGCATTGCACTTGAACTAAATGAGCGGCTAATTAAAGAAGATCAAGTTGAGTACCATGAAGGGCTAAAGTCAAATTTCAGA
GACATGGTAAAAGAATTATCTGACATTATCCATGAGCAGGCAAGTATTAGGATATTACAAGAAGACACAATGCATTCTCCCTGGATGAGC
AACACATTACATGTATTTTGTGCAATTAGTGGTACATCAAGTGACCGAGGTTATGGTTCCCCAAGATACGCTGAAGTGTGAGGAAATGCA
GATGTACGTGACAATGAGACTGACCTTTCTCAGGAATATTTGGAGCTGTGCAAATGTTAAAATTTAAAGATTTGATATACATGGAGTGTT
TCTTCTCGACACCAAAATTTTCATGTGTTCCAACAGGGTGCTTACATATTTGTAAATAAGCAACTTGAAAGTGCCTGGAAAATTGCACCA
CTGTGCTTGGTTTGTACTTTTTTAGGTAAATCTATATGCTGAAAAGTAGAGCTCAAAAACAGTAGTTCAATTTGCTTAATTATTGCTTAA

>40606_40606_2_ITLN1-DOCK11_ITLN1_chr1_160851748_ENST00000326245_DOCK11_chrX_117742246_ENST00000276204_length(amino acids)=1204AA_BP=62
MGVAAGPWWPACTRMTCVGSARWAIAGPVSRAAKQSTQRGTATGPTTTPLDLQRRPRAMTTRTLATTMIAILKQSADFLSINKLLKYSWF
FFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISG
FSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKN
LLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIK
REDSRGSLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVCLFH
FRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTIS
FFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASA
LLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEH
EKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMKEDA
GMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSF
FEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNISRF
VFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSV
QVNAGPLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQASIRILQED

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Fusion Gene PPI Analysis for ITLN1-DOCK11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ITLN1-DOCK11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ITLN1-DOCK11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source