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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITPK1-BTBD7 (FusionGDB2 ID:40651)

Fusion Gene Summary for ITPK1-BTBD7

check button Fusion gene summary
Fusion gene informationFusion gene name: ITPK1-BTBD7
Fusion gene ID: 40651
HgeneTgene
Gene symbol

ITPK1

BTBD7

Gene ID

3705

55727

Gene nameinositol-tetrakisphosphate 1-kinaseBTB domain containing 7
SynonymsITRPK1FUP1
Cytomap

14q32.12

14q32.12

Type of geneprotein-codingprotein-coding
Descriptioninositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinaseBTB/POZ domain-containing protein 7BTB (POZ) domain containing 7
Modification date2020031320200313
UniProtAcc.

Q9P203

Ensembl transtripts involved in fusion geneENST00000267615, ENST00000354313, 
ENST00000555495, ENST00000556603, 
ENST00000556954, 		ENST00000298896, 
ENST00000393170, ENST00000555525, 
ENST00000334746, ENST00000554565, 
Fusion gene scores* DoF score10 X 12 X 8=9604 X 6 X 5=120
# samples 147
** MAII scorelog2(14/960*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITPK1 [Title/Abstract] AND BTBD7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITPK1(93542939)-BTBD7(93730339), # samples:2
ITPK1(93542940)-BTBD7(93730339), # samples:2
ITPK1(93418291)-BTBD7(93717998), # samples:2
Anticipated loss of major functional domain due to fusion event.ITPK1-BTBD7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ITPK1-BTBD7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BTBD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4ON-01AITPK1chr14

93542940

-BTBD7chr14

93730339

-
ChimerDB4ESCATCGA-L5-A4ONITPK1chr14

93542939

-BTBD7chr14

93730339

-
ChimerDB4ESCATCGA-L5-A4ONITPK1chr14

93542940

-BTBD7chr14

93730339

-
ChimerDB4LUADTCGA-38-4630-01AITPK1chr14

93418291

-BTBD7chr14

93717998

-
ChimerDB4LUADTCGA-38-4630ITPK1chr14

93418290

-BTBD7chr14

93717998

-
ChimerDB4OVTCGA-20-1683-01AITPK1chr14

93542940

-BTBD7chr14

93720136

-


Top

Fusion Gene ORF analysis for ITPK1-BTBD7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000267615ENST00000298896ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000298896ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000267615ENST00000298896ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000267615ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5CDS-intronENST00000267615ENST00000393170ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000555525ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000267615ENST00000555525ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000267615ENST00000555525ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000267615ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5CDS-intronENST00000354313ENST00000298896ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000298896ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000354313ENST00000298896ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000354313ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5CDS-intronENST00000354313ENST00000393170ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000555525ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000354313ENST00000555525ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000354313ENST00000555525ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000354313ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5CDS-intronENST00000555495ENST00000298896ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000555495ENST00000298896ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000555495ENST00000555525ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000555495ENST00000555525ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000556603ENST00000298896ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000298896ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000556603ENST00000298896ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000556603ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5CDS-intronENST00000556603ENST00000393170ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000555525ITPK1chr14

93542939

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93730339

-
5CDS-intronENST00000556603ENST00000555525ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5CDS-intronENST00000556603ENST00000555525ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5CDS-intronENST00000556603ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93720136

-
5UTR-3CDSENST00000556954ENST00000334746ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5UTR-3CDSENST00000556954ENST00000334746ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5UTR-3CDSENST00000556954ENST00000393170ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5UTR-3CDSENST00000556954ENST00000393170ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5UTR-3CDSENST00000556954ENST00000554565ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5UTR-3CDSENST00000556954ENST00000554565ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5UTR-intronENST00000556954ENST00000298896ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5UTR-intronENST00000556954ENST00000298896ITPK1chr14

93418290

-BTBD7chr14

93717998

-
5UTR-intronENST00000556954ENST00000555525ITPK1chr14

93418291

-BTBD7chr14

93717998

-
5UTR-intronENST00000556954ENST00000555525ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000334746ITPK1chr14

93542939

-BTBD7chr14

93730339

-
Frame-shiftENST00000267615ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93730339

-
Frame-shiftENST00000267615ENST00000334746ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000334746ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000267615ENST00000393170ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000393170ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000267615ENST00000554565ITPK1chr14

93542939

-BTBD7chr14

93730339

-
Frame-shiftENST00000267615ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93730339

-
Frame-shiftENST00000267615ENST00000554565ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000554565ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000267615ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000354313ENST00000334746ITPK1chr14

93542939

-BTBD7chr14

93730339

-
Frame-shiftENST00000354313ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93730339

-
Frame-shiftENST00000354313ENST00000334746ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000334746ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000354313ENST00000393170ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000393170ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000354313ENST00000554565ITPK1chr14

93542939

-BTBD7chr14

93730339

-
Frame-shiftENST00000354313ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93730339

-
Frame-shiftENST00000354313ENST00000554565ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000554565ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000354313ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000556603ENST00000334746ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000334746ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000556603ENST00000393170ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000393170ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93720136

-
Frame-shiftENST00000556603ENST00000554565ITPK1chr14

93418291

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000554565ITPK1chr14

93418290

-BTBD7chr14

93717998

-
Frame-shiftENST00000556603ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93720136

-
In-frameENST00000555495ENST00000334746ITPK1chr14

93418291

-BTBD7chr14

93717998

-
In-frameENST00000555495ENST00000334746ITPK1chr14

93418290

-BTBD7chr14

93717998

-
In-frameENST00000555495ENST00000393170ITPK1chr14

93418291

-BTBD7chr14

93717998

-
In-frameENST00000555495ENST00000393170ITPK1chr14

93418290

-BTBD7chr14

93717998

-
In-frameENST00000555495ENST00000554565ITPK1chr14

93418291

-BTBD7chr14

93717998

-
In-frameENST00000555495ENST00000554565ITPK1chr14

93418290

-BTBD7chr14

93717998

-
In-frameENST00000556603ENST00000334746ITPK1chr14

93542939

-BTBD7chr14

93730339

-
In-frameENST00000556603ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93730339

-
In-frameENST00000556603ENST00000554565ITPK1chr14

93542939

-BTBD7chr14

93730339

-
In-frameENST00000556603ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-3CDSENST00000555495ENST00000334746ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-3CDSENST00000555495ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-3CDSENST00000555495ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-3CDSENST00000555495ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-3CDSENST00000555495ENST00000554565ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-3CDSENST00000555495ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-3CDSENST00000555495ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-3CDSENST00000556954ENST00000334746ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-3CDSENST00000556954ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-3CDSENST00000556954ENST00000334746ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-3CDSENST00000556954ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-3CDSENST00000556954ENST00000554565ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-3CDSENST00000556954ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-3CDSENST00000556954ENST00000554565ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-intronENST00000555495ENST00000298896ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-intronENST00000555495ENST00000393170ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000555525ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000555495ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-intronENST00000556954ENST00000298896ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000298896ITPK1chr14

93542940

-BTBD7chr14

93720136

-
intron-intronENST00000556954ENST00000393170ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000393170ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000555525ITPK1chr14

93542939

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93730339

-
intron-intronENST00000556954ENST00000555525ITPK1chr14

93542940

-BTBD7chr14

93720136

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000556603ITPK1chr1493542939-ENST00000334746BTBD7chr1493730339-72012411562477773
ENST00000556603ITPK1chr1493542939-ENST00000554565BTBD7chr1493730339-27182411562477773
ENST00000555495ITPK1chr1493418290-ENST00000334746BTBD7chr1493717998-71998291512475774
ENST00000555495ITPK1chr1493418290-ENST00000554565BTBD7chr1493717998-27168291512475774
ENST00000555495ITPK1chr1493418290-ENST00000393170BTBD7chr1493717998-27118291512475774
ENST00000556603ITPK1chr1493542940-ENST00000334746BTBD7chr1493730339-72012411562477773
ENST00000556603ITPK1chr1493542940-ENST00000554565BTBD7chr1493730339-27182411562477773
ENST00000555495ITPK1chr1493418291-ENST00000334746BTBD7chr1493717998-71998291512475774
ENST00000555495ITPK1chr1493418291-ENST00000554565BTBD7chr1493717998-27168291512475774
ENST00000555495ITPK1chr1493418291-ENST00000393170BTBD7chr1493717998-27118291512475774

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000556603ENST00000334746ITPK1chr1493542939-BTBD7chr1493730339-0.0008550660.9991449
ENST00000556603ENST00000554565ITPK1chr1493542939-BTBD7chr1493730339-0.011332780.9886672
ENST00000555495ENST00000334746ITPK1chr1493418290-BTBD7chr1493717998-0.0016456050.99835443
ENST00000555495ENST00000554565ITPK1chr1493418290-BTBD7chr1493717998-0.020124150.9798758
ENST00000555495ENST00000393170ITPK1chr1493418290-BTBD7chr1493717998-0.0205466840.97945327
ENST00000556603ENST00000334746ITPK1chr1493542940-BTBD7chr1493730339-0.0008550660.9991449
ENST00000556603ENST00000554565ITPK1chr1493542940-BTBD7chr1493730339-0.011332780.9886672
ENST00000555495ENST00000334746ITPK1chr1493418291-BTBD7chr1493717998-0.0016456050.99835443
ENST00000555495ENST00000554565ITPK1chr1493418291-BTBD7chr1493717998-0.020124150.9798758
ENST00000555495ENST00000393170ITPK1chr1493418291-BTBD7chr1493717998-0.0205466840.97945327

Top

Fusion Genomic Features for ITPK1-BTBD7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITPK1-BTBD7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:93542939/chr14:93730339)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BTBD7

Q9P203

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPK1chr14:93418290chr14:93717998ENST00000267615-911188_199246415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93418290chr14:93717998ENST00000354313-911188_199246315.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93418290chr14:93717998ENST00000556603-911188_199246415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93418291chr14:93717998ENST00000267615-911188_199246415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93418291chr14:93717998ENST00000354313-911188_199246315.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93418291chr14:93717998ENST00000556603-911188_199246415.0Nucleotide bindingNote=ATP
TgeneBTBD7chr14:93418290chr14:93717998ENST0000029889604756_8250411.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418290chr14:93717998ENST0000029889604849_8560411.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418290chr14:93717998ENST00000334746611756_8255841133.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418290chr14:93717998ENST00000334746611849_8565841133.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418290chr14:93717998ENST0000055456549756_825233782.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418290chr14:93717998ENST0000055456549849_856233782.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418291chr14:93717998ENST0000029889604756_8250411.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418291chr14:93717998ENST0000029889604849_8560411.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418291chr14:93717998ENST00000334746611756_8255841133.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418291chr14:93717998ENST00000334746611849_8565841133.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418291chr14:93717998ENST0000055456549756_825233782.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93418291chr14:93717998ENST0000055456549849_856233782.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542939chr14:93730339ENST0000029889604756_8250411.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542939chr14:93730339ENST0000029889604849_8560411.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542939chr14:93730339ENST00000334746211756_8253871133.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542939chr14:93730339ENST00000334746211849_8563871133.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542939chr14:93730339ENST0000055456509756_82536782.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542939chr14:93730339ENST0000055456509849_85636782.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542940chr14:93730339ENST0000029889604756_8250411.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542940chr14:93730339ENST0000029889604849_8560411.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542940chr14:93730339ENST00000334746211756_8253871133.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542940chr14:93730339ENST00000334746211849_8563871133.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93542940chr14:93730339ENST0000055456509756_82536782.0Compositional biasNote=Pro-rich
TgeneBTBD7chr14:93542940chr14:93730339ENST0000055456509849_85636782.0Compositional biasNote=Poly-Ala
TgeneBTBD7chr14:93418290chr14:93717998ENST0000029889604142_2110411.0DomainBTB 1
TgeneBTBD7chr14:93418290chr14:93717998ENST0000029889604247_3410411.0DomainBTB 2
TgeneBTBD7chr14:93418290chr14:93717998ENST0000029889604413_4790411.0DomainNote=BACK
TgeneBTBD7chr14:93418290chr14:93717998ENST0000055456549247_341233782.0DomainBTB 2
TgeneBTBD7chr14:93418290chr14:93717998ENST0000055456549413_479233782.0DomainNote=BACK
TgeneBTBD7chr14:93418291chr14:93717998ENST0000029889604142_2110411.0DomainBTB 1
TgeneBTBD7chr14:93418291chr14:93717998ENST0000029889604247_3410411.0DomainBTB 2
TgeneBTBD7chr14:93418291chr14:93717998ENST0000029889604413_4790411.0DomainNote=BACK
TgeneBTBD7chr14:93418291chr14:93717998ENST0000055456549247_341233782.0DomainBTB 2
TgeneBTBD7chr14:93418291chr14:93717998ENST0000055456549413_479233782.0DomainNote=BACK
TgeneBTBD7chr14:93542939chr14:93730339ENST0000029889604142_2110411.0DomainBTB 1
TgeneBTBD7chr14:93542939chr14:93730339ENST0000029889604247_3410411.0DomainBTB 2
TgeneBTBD7chr14:93542939chr14:93730339ENST0000029889604413_4790411.0DomainNote=BACK
TgeneBTBD7chr14:93542939chr14:93730339ENST00000334746211413_4793871133.0DomainNote=BACK
TgeneBTBD7chr14:93542939chr14:93730339ENST0000055456509142_21136782.0DomainBTB 1
TgeneBTBD7chr14:93542939chr14:93730339ENST0000055456509247_34136782.0DomainBTB 2
TgeneBTBD7chr14:93542939chr14:93730339ENST0000055456509413_47936782.0DomainNote=BACK
TgeneBTBD7chr14:93542940chr14:93730339ENST0000029889604142_2110411.0DomainBTB 1
TgeneBTBD7chr14:93542940chr14:93730339ENST0000029889604247_3410411.0DomainBTB 2
TgeneBTBD7chr14:93542940chr14:93730339ENST0000029889604413_4790411.0DomainNote=BACK
TgeneBTBD7chr14:93542940chr14:93730339ENST00000334746211413_4793871133.0DomainNote=BACK
TgeneBTBD7chr14:93542940chr14:93730339ENST0000055456509142_21136782.0DomainBTB 1
TgeneBTBD7chr14:93542940chr14:93730339ENST0000055456509247_34136782.0DomainBTB 2
TgeneBTBD7chr14:93542940chr14:93730339ENST0000055456509413_47936782.0DomainNote=BACK

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPK1chr14:93418290chr14:93717998ENST00000267615-911117_325246415.0DomainATP-grasp
HgeneITPK1chr14:93418290chr14:93717998ENST00000354313-911117_325246315.0DomainATP-grasp
HgeneITPK1chr14:93418290chr14:93717998ENST00000556603-911117_325246415.0DomainATP-grasp
HgeneITPK1chr14:93418291chr14:93717998ENST00000267615-911117_325246415.0DomainATP-grasp
HgeneITPK1chr14:93418291chr14:93717998ENST00000354313-911117_325246315.0DomainATP-grasp
HgeneITPK1chr14:93418291chr14:93717998ENST00000556603-911117_325246415.0DomainATP-grasp
HgeneITPK1chr14:93542939chr14:93730339ENST00000267615-311117_32540415.0DomainATP-grasp
HgeneITPK1chr14:93542939chr14:93730339ENST00000354313-311117_32540315.0DomainATP-grasp
HgeneITPK1chr14:93542939chr14:93730339ENST00000556603-311117_32540415.0DomainATP-grasp
HgeneITPK1chr14:93542940chr14:93730339ENST00000267615-311117_32540415.0DomainATP-grasp
HgeneITPK1chr14:93542940chr14:93730339ENST00000354313-311117_32540315.0DomainATP-grasp
HgeneITPK1chr14:93542940chr14:93730339ENST00000556603-311117_32540415.0DomainATP-grasp
HgeneITPK1chr14:93542939chr14:93730339ENST00000267615-311188_19940415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93542939chr14:93730339ENST00000354313-311188_19940315.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93542939chr14:93730339ENST00000556603-311188_19940415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93542940chr14:93730339ENST00000267615-311188_19940415.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93542940chr14:93730339ENST00000354313-311188_19940315.0Nucleotide bindingNote=ATP
HgeneITPK1chr14:93542940chr14:93730339ENST00000556603-311188_19940415.0Nucleotide bindingNote=ATP
TgeneBTBD7chr14:93418290chr14:93717998ENST00000334746611142_2115841133.0DomainBTB 1
TgeneBTBD7chr14:93418290chr14:93717998ENST00000334746611247_3415841133.0DomainBTB 2
TgeneBTBD7chr14:93418290chr14:93717998ENST00000334746611413_4795841133.0DomainNote=BACK
TgeneBTBD7chr14:93418290chr14:93717998ENST0000055456549142_211233782.0DomainBTB 1
TgeneBTBD7chr14:93418291chr14:93717998ENST00000334746611142_2115841133.0DomainBTB 1
TgeneBTBD7chr14:93418291chr14:93717998ENST00000334746611247_3415841133.0DomainBTB 2
TgeneBTBD7chr14:93418291chr14:93717998ENST00000334746611413_4795841133.0DomainNote=BACK
TgeneBTBD7chr14:93418291chr14:93717998ENST0000055456549142_211233782.0DomainBTB 1
TgeneBTBD7chr14:93542939chr14:93730339ENST00000334746211142_2113871133.0DomainBTB 1
TgeneBTBD7chr14:93542939chr14:93730339ENST00000334746211247_3413871133.0DomainBTB 2
TgeneBTBD7chr14:93542940chr14:93730339ENST00000334746211142_2113871133.0DomainBTB 1
TgeneBTBD7chr14:93542940chr14:93730339ENST00000334746211247_3413871133.0DomainBTB 2


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Fusion Gene Sequence for ITPK1-BTBD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40651_40651_1_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000334746_length(transcript)=7199nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG
TCGGGAGGCATTTTTAAGAACAAGCAGGCTGGCACTTTTTATTTCTCTTTACAAATGATGGAATTTTTTTGCACTTGTACATTTATTTTC
TCTGTATTGATTTTATATCAGTATGTTAAACTTTATTGCCACATTTAAAGGACTGTATTTTCATACTTTTTTGCATTTTACCTTTCATCT
ACCAATCCATGTGCATTGGATTGCACACTAAGATGTATTTTCTTACGAAATAGTTCTGTGTTTATTTTTTAATTATAGAAATTCCAAAGA
ACAGCACATCAGAATGCTCCTCTCTTTTCAGTAATTGTTTTAGTTCAGAGATCTTCCCGCTCAGCCTCCATAAATCTAATGTCATTTTTT
TTTTAATAAGTCCTAGGAGCTGGGCTTCATTCCTCCAGCGGGAGTCCAGTCAGGGTCCTGAAGTTTGCTGGTTCAGGAAAGAACAGGAAA
GAGAAAAGCCTTCTGTGCCCAGGCTAAAGCTGTTACATTTCCACAGTGTGGATGCAGTCAGAATCCCTGCACATTCTGGTCATAAGGATT
AGAGTCACCAGATGAGGCTCTAAACAGATCGCATCCCTTGGAATTAGAAAGCAGTGGAGACCGGGCGCAGTGACTCACACCTGTGATCGG
CACTTCGGAAGGCCGAGGCGGGCAGATCACTGAAGCTCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACTCCATTTCTATAAAAA
ATACAAAAAAAAAAAAATCTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGGGGCTGAGGTGGCAGGATCGCTTGAGC
CTGGGAGGTTGAGACTGCAGTGAGCCAAGATTGCACCACTGTGCTCCCACCTGGGCAACAGTGAGACCCTGTCTCAAAAAAAAAAAAAAA
GGCAGTGGAAATAGAGAAGTAACTTAAAGGTCACACTGACAGAATTTCTGGTTCTGAGCGTCAACTCTCCAGCTGTGATGGCGGAACTGA
CTGCTTGCTGCCTTTAATTGTCTTGCTCTCTATGGGAAAAAAACAAAAGGGCTTCAGTCTCATGGATGTTATTTGGTGTTTGTAAAGATA
CGTTTTCTTTTAAACGATTTTCAAAATATGTCTAAATTTTGGTGTTGTGTAATGCATAATGCTTTCTCACCAACAGAAAAAAGGAAAAAA
ATTGTTTTCAGTTAAACACTACATGTCCTACTTGAACTCCACTGGGACGCTGGTTTGGCATTTACTAAACCACTGAGCACATGGGGTCTT
TCAGGATCCTCTCCCTTGGAAGGGCAATGTGTGAGCTAAGGACTGTTTTTTTTCTTACTCTCCAATGTAAATATATGAGTATTTGAGTTT
TTAAATCACTTCAACATTATTTGAGCATTTACTTTGTATTTTTACAAACACATAAACACACAGCCGTAGCACTTAGAAGAAAAGAGGCTT
TCTAAGCATTCCTTCCTCTGCAGGATATTTGGGATCCTCTTTTCTATGTATGTATATATATAAAAAACTATGAATCACTCACACTCACTC
GAAAACTATGCAGGGCTAGGGAGCGTTTATGAGCTACCGGGTAAATGAATTACATGCACTTTGAAGTAAATAGGTTTTCTATTGGGTGTC
AACAACGCTGATTTCTCCCAAAACTATAGTTTCTCTTACGGTCTTTTCCTCCTTTACCCTGTGGATATACACTCAGGAATAATCTGACAT
TTTAGAAAAGCCGAACAGTAGATAGTCTCCAAGATGGGAAACATGTCGTGTGTCTGCACGCCCCGGCAAACTGCCGCCACTCGTTCTGCT
GCCTGACTGGTTAGCTGCTGTGCGGGTGCGCTCGGTGACACTGGTGGTGGTGCACGCTCCCGAGCTCCCAGAGTTAACACTAATCTGCAG
GTCGGCTGTGCATCGCATTCGAGGCTCCTTTTTTAAAGAGAAAAGCATAGGCCTCTGTTCTCATTTGTAAGAAGTTTGACTCATAATAGA
AGACGGTGTCTTTTGAAGCCCAGTCTCTGTCTGTCTTCAGAAACAAAAGTGAATGCCGTCATGTTCCTTGATGTGTGTTTCTGCCACATA
TGTATGTTGACATGTTCATGTACTGCGCCGGTACTGCAAGTAAGACTCAACAGACCTAATTTGGATGGGGAGAAAAACTCTCATCCCTGA
CCCTTCCCCCCCCGCAAATGTTAGACCAGAGCTGTTGATCCCACACATTCATTTTTCTGAAAATTCATGAACTATTCTCTCATATCCCTG
AAATATAAAAGTAAGTGGCCACTATTCCTAAGATTATTTAGTTTATAAAGTTTGCTTTTAATCATACAATAGCTTACCTGGCTAAAACTT
TGCGTATAAAGGGAAAACTTGCTTTAATCTGTGGGATTGCGGACCGATGCGACTTGCAGAAGGTAAACAGGCGTGGGTTTTGTGTGCGTT
AGGTTAGGTGTTAGTGGACTTTTAATGTATCTTGTGAAGTATGGTTACTAGGGTAGGTTCAAGAGCTACATGCCTCTGGCTTTTGAACCC
ATCTATTAAATCTTTTTTAATGCTGTACTAAGATAAATGTGAAGTCTGAGTAAGGTTGCTCTCAGAAAAAAAAAAAAAGCATATATATAT
ATAAAATAAAATTTAGGCCATGGGAACTGGCATTTTACTTGGTATAGGAATTTAATGAGAACCAAATCACAAAAATACCAGATCTCCTTT
TGAGATCGTGGACAATCAGGCCTTTGGACAATCACCGCTTCCAGTGCCCGCTGTGCGTTGAGGTTAGAGACCTACCGTTTACACGCTAGA
GCCGAGAGGACGTTCAAGTTTCTTAAAGATGCTGTTGGTCTTTTTTCTTATGTTATTGTTTTAGTTTTGTGATTTTGATGAATAATTGAA
GTTCAGAGTCACCCGTGGCTCCTAAGGAAAAAACAGCATCATGAAAGGCAAAAAGTATTTGAAACGTAATTGTTTCAATTTTCCACGCCC
GTTCTCACATGCCCCCTTTAGCTTTATTTCTGGGAACATGTCACTAGACCTCAGCTAGCCTGACACCGCAATAACCCGTTAGGCTTTGAG
GCTTTTCAGTGAATTCTTGACATTTAAATCTTCTTATAGAATTCTTTATGAAGCCTTAACTAATTCTTGTTTTTGCTTCCTCAGAAACTT
TTTATTGCATCTGCCATCCTTCATTGGATTTTTGTTTTGGTTTGTTGTTGCCATTCTAGCAATGAGCTTAGTCCTTGTACATCTGCATTA
AGGTGCCGATGCAGAAGGCAAATTGGAAACACGCGCCAGCGGCAGTGGGGCTCAAAGCCGACCTCCATGCATCATTCTCTAGAGTTGAAA
GGATTGACATTTCTCAGTAACTACCCGGCAAAATATATATTTTCATAATGTTGAATTTGCCTTTTAGGAAAACAATGTTTCATGAAACAC
TTGTAAGATACTTATTTTGAAATTAATTATAAGGCATTCATATTTTTAGGACTGAATTCAAAGGGAAATGCTTCTTTGACTTTTTTTCAT
TGTTCGGTTGACTTTCAGCTTTCTGGAGTGACAAAGCAGCAGTGATGGGTGCTATTCCTGGTTCTGTGGTGGTTTACTTTGTCTACTAAG
TGATTTACTTTCAAACCTCATTACAGATAATCTTACTAAAAGACTTAACATGCACACTGCTAAAAGGTGTTTTACTGTTTTCCATTAACG
CTGTTGTATGAACAATATTTGGTGACATGTTGTCTTTTTGTCCTGTAGATTGTCATATCTGTTATGTAGTTATCCTTTTGGCAAGTCCTT
TGATTTTTTTTTCCTCTAGAAAATCCTCAGACTGTCAATCTTCCATATTTTGAATATTATAATGCTGTGGCCATTTCTATAGAAAGATTA
CTTGCAAGTGTGTGTCTTGAAAATAACCTCTTGTATTTGTGTGTTTATGTGAGTTCTGTCTAAGAGATCAGATAAGCTCTGGAAGCTTCA
TCATCTGTACCTACATGTAACTGTATCTGGGTTACATGGGCAGGCGGTACCAAGTCCTGCTCTTCGATGGGGTGGCTGAGAGATAAAGGT
TCCTGAACTCTCCTTGCTGTGTATGCACCACATCTGTACTTCAGAGAGGTGGAAAATCATCTACAACACTGCGTTTCTTGTGGTTGTGCT
GTTACTGGTATAAAGTCAAGTGCCTTCAATGCTAAAGGCTCAGAAATTTTTCTTAAACTGATTTCATGTCCTATGCAAGTGTTTTCTACA
ACCTGCATAACCAGTACTTTGTAAAACTTGTTTACGCTTCAATTGTACATAGTGATTTTTAAAGAAATATATAGTATTTTTATTTAGGTA
CCTCCAAACTTGAATTCGTCTGTGTGAAGCATTGTAAAACGATACATTTCTCTTTTGAGTACCATTACAGTTGTACAGAGGTTTTCACTG

>40651_40651_1_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000334746_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_2_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000393170_length(transcript)=2711nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG

>40651_40651_2_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000393170_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_3_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000554565_length(transcript)=2716nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG

>40651_40651_3_ITPK1-BTBD7_ITPK1_chr14_93418290_ENST00000555495_BTBD7_chr14_93717998_ENST00000554565_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_4_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000334746_length(transcript)=7199nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG
TCGGGAGGCATTTTTAAGAACAAGCAGGCTGGCACTTTTTATTTCTCTTTACAAATGATGGAATTTTTTTGCACTTGTACATTTATTTTC
TCTGTATTGATTTTATATCAGTATGTTAAACTTTATTGCCACATTTAAAGGACTGTATTTTCATACTTTTTTGCATTTTACCTTTCATCT
ACCAATCCATGTGCATTGGATTGCACACTAAGATGTATTTTCTTACGAAATAGTTCTGTGTTTATTTTTTAATTATAGAAATTCCAAAGA
ACAGCACATCAGAATGCTCCTCTCTTTTCAGTAATTGTTTTAGTTCAGAGATCTTCCCGCTCAGCCTCCATAAATCTAATGTCATTTTTT
TTTTAATAAGTCCTAGGAGCTGGGCTTCATTCCTCCAGCGGGAGTCCAGTCAGGGTCCTGAAGTTTGCTGGTTCAGGAAAGAACAGGAAA
GAGAAAAGCCTTCTGTGCCCAGGCTAAAGCTGTTACATTTCCACAGTGTGGATGCAGTCAGAATCCCTGCACATTCTGGTCATAAGGATT
AGAGTCACCAGATGAGGCTCTAAACAGATCGCATCCCTTGGAATTAGAAAGCAGTGGAGACCGGGCGCAGTGACTCACACCTGTGATCGG
CACTTCGGAAGGCCGAGGCGGGCAGATCACTGAAGCTCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACTCCATTTCTATAAAAA
ATACAAAAAAAAAAAAATCTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGGGGCTGAGGTGGCAGGATCGCTTGAGC
CTGGGAGGTTGAGACTGCAGTGAGCCAAGATTGCACCACTGTGCTCCCACCTGGGCAACAGTGAGACCCTGTCTCAAAAAAAAAAAAAAA
GGCAGTGGAAATAGAGAAGTAACTTAAAGGTCACACTGACAGAATTTCTGGTTCTGAGCGTCAACTCTCCAGCTGTGATGGCGGAACTGA
CTGCTTGCTGCCTTTAATTGTCTTGCTCTCTATGGGAAAAAAACAAAAGGGCTTCAGTCTCATGGATGTTATTTGGTGTTTGTAAAGATA
CGTTTTCTTTTAAACGATTTTCAAAATATGTCTAAATTTTGGTGTTGTGTAATGCATAATGCTTTCTCACCAACAGAAAAAAGGAAAAAA
ATTGTTTTCAGTTAAACACTACATGTCCTACTTGAACTCCACTGGGACGCTGGTTTGGCATTTACTAAACCACTGAGCACATGGGGTCTT
TCAGGATCCTCTCCCTTGGAAGGGCAATGTGTGAGCTAAGGACTGTTTTTTTTCTTACTCTCCAATGTAAATATATGAGTATTTGAGTTT
TTAAATCACTTCAACATTATTTGAGCATTTACTTTGTATTTTTACAAACACATAAACACACAGCCGTAGCACTTAGAAGAAAAGAGGCTT
TCTAAGCATTCCTTCCTCTGCAGGATATTTGGGATCCTCTTTTCTATGTATGTATATATATAAAAAACTATGAATCACTCACACTCACTC
GAAAACTATGCAGGGCTAGGGAGCGTTTATGAGCTACCGGGTAAATGAATTACATGCACTTTGAAGTAAATAGGTTTTCTATTGGGTGTC
AACAACGCTGATTTCTCCCAAAACTATAGTTTCTCTTACGGTCTTTTCCTCCTTTACCCTGTGGATATACACTCAGGAATAATCTGACAT
TTTAGAAAAGCCGAACAGTAGATAGTCTCCAAGATGGGAAACATGTCGTGTGTCTGCACGCCCCGGCAAACTGCCGCCACTCGTTCTGCT
GCCTGACTGGTTAGCTGCTGTGCGGGTGCGCTCGGTGACACTGGTGGTGGTGCACGCTCCCGAGCTCCCAGAGTTAACACTAATCTGCAG
GTCGGCTGTGCATCGCATTCGAGGCTCCTTTTTTAAAGAGAAAAGCATAGGCCTCTGTTCTCATTTGTAAGAAGTTTGACTCATAATAGA
AGACGGTGTCTTTTGAAGCCCAGTCTCTGTCTGTCTTCAGAAACAAAAGTGAATGCCGTCATGTTCCTTGATGTGTGTTTCTGCCACATA
TGTATGTTGACATGTTCATGTACTGCGCCGGTACTGCAAGTAAGACTCAACAGACCTAATTTGGATGGGGAGAAAAACTCTCATCCCTGA
CCCTTCCCCCCCCGCAAATGTTAGACCAGAGCTGTTGATCCCACACATTCATTTTTCTGAAAATTCATGAACTATTCTCTCATATCCCTG
AAATATAAAAGTAAGTGGCCACTATTCCTAAGATTATTTAGTTTATAAAGTTTGCTTTTAATCATACAATAGCTTACCTGGCTAAAACTT
TGCGTATAAAGGGAAAACTTGCTTTAATCTGTGGGATTGCGGACCGATGCGACTTGCAGAAGGTAAACAGGCGTGGGTTTTGTGTGCGTT
AGGTTAGGTGTTAGTGGACTTTTAATGTATCTTGTGAAGTATGGTTACTAGGGTAGGTTCAAGAGCTACATGCCTCTGGCTTTTGAACCC
ATCTATTAAATCTTTTTTAATGCTGTACTAAGATAAATGTGAAGTCTGAGTAAGGTTGCTCTCAGAAAAAAAAAAAAAGCATATATATAT
ATAAAATAAAATTTAGGCCATGGGAACTGGCATTTTACTTGGTATAGGAATTTAATGAGAACCAAATCACAAAAATACCAGATCTCCTTT
TGAGATCGTGGACAATCAGGCCTTTGGACAATCACCGCTTCCAGTGCCCGCTGTGCGTTGAGGTTAGAGACCTACCGTTTACACGCTAGA
GCCGAGAGGACGTTCAAGTTTCTTAAAGATGCTGTTGGTCTTTTTTCTTATGTTATTGTTTTAGTTTTGTGATTTTGATGAATAATTGAA
GTTCAGAGTCACCCGTGGCTCCTAAGGAAAAAACAGCATCATGAAAGGCAAAAAGTATTTGAAACGTAATTGTTTCAATTTTCCACGCCC
GTTCTCACATGCCCCCTTTAGCTTTATTTCTGGGAACATGTCACTAGACCTCAGCTAGCCTGACACCGCAATAACCCGTTAGGCTTTGAG
GCTTTTCAGTGAATTCTTGACATTTAAATCTTCTTATAGAATTCTTTATGAAGCCTTAACTAATTCTTGTTTTTGCTTCCTCAGAAACTT
TTTATTGCATCTGCCATCCTTCATTGGATTTTTGTTTTGGTTTGTTGTTGCCATTCTAGCAATGAGCTTAGTCCTTGTACATCTGCATTA
AGGTGCCGATGCAGAAGGCAAATTGGAAACACGCGCCAGCGGCAGTGGGGCTCAAAGCCGACCTCCATGCATCATTCTCTAGAGTTGAAA
GGATTGACATTTCTCAGTAACTACCCGGCAAAATATATATTTTCATAATGTTGAATTTGCCTTTTAGGAAAACAATGTTTCATGAAACAC
TTGTAAGATACTTATTTTGAAATTAATTATAAGGCATTCATATTTTTAGGACTGAATTCAAAGGGAAATGCTTCTTTGACTTTTTTTCAT
TGTTCGGTTGACTTTCAGCTTTCTGGAGTGACAAAGCAGCAGTGATGGGTGCTATTCCTGGTTCTGTGGTGGTTTACTTTGTCTACTAAG
TGATTTACTTTCAAACCTCATTACAGATAATCTTACTAAAAGACTTAACATGCACACTGCTAAAAGGTGTTTTACTGTTTTCCATTAACG
CTGTTGTATGAACAATATTTGGTGACATGTTGTCTTTTTGTCCTGTAGATTGTCATATCTGTTATGTAGTTATCCTTTTGGCAAGTCCTT
TGATTTTTTTTTCCTCTAGAAAATCCTCAGACTGTCAATCTTCCATATTTTGAATATTATAATGCTGTGGCCATTTCTATAGAAAGATTA
CTTGCAAGTGTGTGTCTTGAAAATAACCTCTTGTATTTGTGTGTTTATGTGAGTTCTGTCTAAGAGATCAGATAAGCTCTGGAAGCTTCA
TCATCTGTACCTACATGTAACTGTATCTGGGTTACATGGGCAGGCGGTACCAAGTCCTGCTCTTCGATGGGGTGGCTGAGAGATAAAGGT
TCCTGAACTCTCCTTGCTGTGTATGCACCACATCTGTACTTCAGAGAGGTGGAAAATCATCTACAACACTGCGTTTCTTGTGGTTGTGCT
GTTACTGGTATAAAGTCAAGTGCCTTCAATGCTAAAGGCTCAGAAATTTTTCTTAAACTGATTTCATGTCCTATGCAAGTGTTTTCTACA
ACCTGCATAACCAGTACTTTGTAAAACTTGTTTACGCTTCAATTGTACATAGTGATTTTTAAAGAAATATATAGTATTTTTATTTAGGTA
CCTCCAAACTTGAATTCGTCTGTGTGAAGCATTGTAAAACGATACATTTCTCTTTTGAGTACCATTACAGTTGTACAGAGGTTTTCACTG

>40651_40651_4_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000334746_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_5_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000393170_length(transcript)=2711nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG

>40651_40651_5_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000393170_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_6_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000554565_length(transcript)=2716nt_BP=829nt
GTTCCGCGTCCCCGCCGCCGGGAGGAGGTGCCCACTCGCTCGCGGCGCGCGCCGGCCGCCAGACTCGGCCTGTGGGCGATTTCCTCCGGA
CCCAGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAAGAAGC
TGAATTTCCAGGCCTTCGCCGAGCTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCT
GACTGACGTCATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGA
GACCATCGTCCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACAT
GGAAGACGACAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTT
GACTTTCCCATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGC
CATCCAGCCACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGT
CCAGAGGCCCTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTC
GTCATCGGTCCTGACGGAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAATGT
GCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGCCC
TCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACGGA
GCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGTCT
TGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATGAG
ACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCCTT
GCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAGCA
CCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTGCC
GAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCAAC
AGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGTGT
GTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGGCC
TCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAAAA
TCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCTTC
GCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACGTC
TCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTGGA
TGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGAAC
TGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCCGG
TAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGGAG
GTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCCCA
TTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTGTA
TATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTATG

>40651_40651_6_ITPK1-BTBD7_ITPK1_chr14_93418291_ENST00000555495_BTBD7_chr14_93717998_ENST00000554565_length(amino acids)=774AA_BP=226
MAEREENQEAEFPGLRRAVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSY
ELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKV
FVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTESVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISH
QQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERF
GDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAP
KAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELS
QSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGL
KSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSAC

--------------------------------------------------------------
>40651_40651_7_ITPK1-BTBD7_ITPK1_chr14_93542939_ENST00000556603_BTBD7_chr14_93730339_ENST00000334746_length(transcript)=7201nt_BP=241nt
GCGGGCAGGGGCGGCGAGTGCGCGGGCGCTCGCCGCCGCCCTTCTCGGCGGGCAGCGCGCGAGGACCAGGCCGAGGAGGAAGTGGCGGCG
GCGGCGGCGGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAA
GAAGCTGAATTTCCAGGCCTTCGCCGAGCTGTGCAGGAAGCGAGGGATGGAGGTTGTGCAGGCTGTGAGGATATCATTGCTGAGAGCATC
TCATTAGATACCTTAATTGCCATCCTCAAGTGGAGTTCTCATCCATATGGCTCTAAATGGGTGCACCGACAAGCTTTACATTTCCTCTGT
GAGGAATTTTCCCAGGTCATGACTTCGGATGTTTTTTATGAACTCAGCAAAGACCATCTGCTTACTGCTATCCAGTCTGACTACCTACAG
GCAAGTGAACAAGATATCCTTAAATATCTGATTAAATGGGGAGAGCATCAGTTGATGAAAAGAATAGCAGATAGAGAGCCAAACTTACTG
AGTGGCACTGCCCATAGTGTGAACAAAAGAGGTGTAAAAAGACGGGACCTGGACATGGAAGAGCTCAGAGAGATCCTTTCTTCTCTCTTA
CCTTTTGTGCGAATTGAACACATCTTACCTATAAACAGTGAAGTCTTAAGTGATGCAATGAAAAGAGGCTTGATTAGTACTCCTCCATCA
GATATGCTTCCTACAACAGAAGGTGGGAAGTCAAATGCCTGGTTACGGCAAAAAAATGCTGGCATCTATGTTCGTCCTCGACTCTTCTCT
CCCTATGTGGAAGAAGCAAAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAAT
GTGCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGC
CCTCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACG
GAGCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGT
CTTGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATG
AGACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCC
TTGCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAG
CACCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTG
CCGAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCA
ACAGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGT
GTGTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGG
CCTCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAA
AATCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCT
TCGCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACG
TCTCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTG
GATGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGA
ACTGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCC
GGTAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGG
AGGTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCC
CATTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTG
TATATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTA
TGTCGGGAGGCATTTTTAAGAACAAGCAGGCTGGCACTTTTTATTTCTCTTTACAAATGATGGAATTTTTTTGCACTTGTACATTTATTT
TCTCTGTATTGATTTTATATCAGTATGTTAAACTTTATTGCCACATTTAAAGGACTGTATTTTCATACTTTTTTGCATTTTACCTTTCAT
CTACCAATCCATGTGCATTGGATTGCACACTAAGATGTATTTTCTTACGAAATAGTTCTGTGTTTATTTTTTAATTATAGAAATTCCAAA
GAACAGCACATCAGAATGCTCCTCTCTTTTCAGTAATTGTTTTAGTTCAGAGATCTTCCCGCTCAGCCTCCATAAATCTAATGTCATTTT
TTTTTTAATAAGTCCTAGGAGCTGGGCTTCATTCCTCCAGCGGGAGTCCAGTCAGGGTCCTGAAGTTTGCTGGTTCAGGAAAGAACAGGA
AAGAGAAAAGCCTTCTGTGCCCAGGCTAAAGCTGTTACATTTCCACAGTGTGGATGCAGTCAGAATCCCTGCACATTCTGGTCATAAGGA
TTAGAGTCACCAGATGAGGCTCTAAACAGATCGCATCCCTTGGAATTAGAAAGCAGTGGAGACCGGGCGCAGTGACTCACACCTGTGATC
GGCACTTCGGAAGGCCGAGGCGGGCAGATCACTGAAGCTCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACTCCATTTCTATAAA
AAATACAAAAAAAAAAAAATCTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGGGGCTGAGGTGGCAGGATCGCTTGA
GCCTGGGAGGTTGAGACTGCAGTGAGCCAAGATTGCACCACTGTGCTCCCACCTGGGCAACAGTGAGACCCTGTCTCAAAAAAAAAAAAA
AAGGCAGTGGAAATAGAGAAGTAACTTAAAGGTCACACTGACAGAATTTCTGGTTCTGAGCGTCAACTCTCCAGCTGTGATGGCGGAACT
GACTGCTTGCTGCCTTTAATTGTCTTGCTCTCTATGGGAAAAAAACAAAAGGGCTTCAGTCTCATGGATGTTATTTGGTGTTTGTAAAGA
TACGTTTTCTTTTAAACGATTTTCAAAATATGTCTAAATTTTGGTGTTGTGTAATGCATAATGCTTTCTCACCAACAGAAAAAAGGAAAA
AAATTGTTTTCAGTTAAACACTACATGTCCTACTTGAACTCCACTGGGACGCTGGTTTGGCATTTACTAAACCACTGAGCACATGGGGTC
TTTCAGGATCCTCTCCCTTGGAAGGGCAATGTGTGAGCTAAGGACTGTTTTTTTTCTTACTCTCCAATGTAAATATATGAGTATTTGAGT
TTTTAAATCACTTCAACATTATTTGAGCATTTACTTTGTATTTTTACAAACACATAAACACACAGCCGTAGCACTTAGAAGAAAAGAGGC
TTTCTAAGCATTCCTTCCTCTGCAGGATATTTGGGATCCTCTTTTCTATGTATGTATATATATAAAAAACTATGAATCACTCACACTCAC
TCGAAAACTATGCAGGGCTAGGGAGCGTTTATGAGCTACCGGGTAAATGAATTACATGCACTTTGAAGTAAATAGGTTTTCTATTGGGTG
TCAACAACGCTGATTTCTCCCAAAACTATAGTTTCTCTTACGGTCTTTTCCTCCTTTACCCTGTGGATATACACTCAGGAATAATCTGAC
ATTTTAGAAAAGCCGAACAGTAGATAGTCTCCAAGATGGGAAACATGTCGTGTGTCTGCACGCCCCGGCAAACTGCCGCCACTCGTTCTG
CTGCCTGACTGGTTAGCTGCTGTGCGGGTGCGCTCGGTGACACTGGTGGTGGTGCACGCTCCCGAGCTCCCAGAGTTAACACTAATCTGC
AGGTCGGCTGTGCATCGCATTCGAGGCTCCTTTTTTAAAGAGAAAAGCATAGGCCTCTGTTCTCATTTGTAAGAAGTTTGACTCATAATA
GAAGACGGTGTCTTTTGAAGCCCAGTCTCTGTCTGTCTTCAGAAACAAAAGTGAATGCCGTCATGTTCCTTGATGTGTGTTTCTGCCACA
TATGTATGTTGACATGTTCATGTACTGCGCCGGTACTGCAAGTAAGACTCAACAGACCTAATTTGGATGGGGAGAAAAACTCTCATCCCT
GACCCTTCCCCCCCCGCAAATGTTAGACCAGAGCTGTTGATCCCACACATTCATTTTTCTGAAAATTCATGAACTATTCTCTCATATCCC
TGAAATATAAAAGTAAGTGGCCACTATTCCTAAGATTATTTAGTTTATAAAGTTTGCTTTTAATCATACAATAGCTTACCTGGCTAAAAC
TTTGCGTATAAAGGGAAAACTTGCTTTAATCTGTGGGATTGCGGACCGATGCGACTTGCAGAAGGTAAACAGGCGTGGGTTTTGTGTGCG
TTAGGTTAGGTGTTAGTGGACTTTTAATGTATCTTGTGAAGTATGGTTACTAGGGTAGGTTCAAGAGCTACATGCCTCTGGCTTTTGAAC
CCATCTATTAAATCTTTTTTAATGCTGTACTAAGATAAATGTGAAGTCTGAGTAAGGTTGCTCTCAGAAAAAAAAAAAAAGCATATATAT
ATATAAAATAAAATTTAGGCCATGGGAACTGGCATTTTACTTGGTATAGGAATTTAATGAGAACCAAATCACAAAAATACCAGATCTCCT
TTTGAGATCGTGGACAATCAGGCCTTTGGACAATCACCGCTTCCAGTGCCCGCTGTGCGTTGAGGTTAGAGACCTACCGTTTACACGCTA
GAGCCGAGAGGACGTTCAAGTTTCTTAAAGATGCTGTTGGTCTTTTTTCTTATGTTATTGTTTTAGTTTTGTGATTTTGATGAATAATTG
AAGTTCAGAGTCACCCGTGGCTCCTAAGGAAAAAACAGCATCATGAAAGGCAAAAAGTATTTGAAACGTAATTGTTTCAATTTTCCACGC
CCGTTCTCACATGCCCCCTTTAGCTTTATTTCTGGGAACATGTCACTAGACCTCAGCTAGCCTGACACCGCAATAACCCGTTAGGCTTTG
AGGCTTTTCAGTGAATTCTTGACATTTAAATCTTCTTATAGAATTCTTTATGAAGCCTTAACTAATTCTTGTTTTTGCTTCCTCAGAAAC
TTTTTATTGCATCTGCCATCCTTCATTGGATTTTTGTTTTGGTTTGTTGTTGCCATTCTAGCAATGAGCTTAGTCCTTGTACATCTGCAT
TAAGGTGCCGATGCAGAAGGCAAATTGGAAACACGCGCCAGCGGCAGTGGGGCTCAAAGCCGACCTCCATGCATCATTCTCTAGAGTTGA
AAGGATTGACATTTCTCAGTAACTACCCGGCAAAATATATATTTTCATAATGTTGAATTTGCCTTTTAGGAAAACAATGTTTCATGAAAC
ACTTGTAAGATACTTATTTTGAAATTAATTATAAGGCATTCATATTTTTAGGACTGAATTCAAAGGGAAATGCTTCTTTGACTTTTTTTC
ATTGTTCGGTTGACTTTCAGCTTTCTGGAGTGACAAAGCAGCAGTGATGGGTGCTATTCCTGGTTCTGTGGTGGTTTACTTTGTCTACTA
AGTGATTTACTTTCAAACCTCATTACAGATAATCTTACTAAAAGACTTAACATGCACACTGCTAAAAGGTGTTTTACTGTTTTCCATTAA
CGCTGTTGTATGAACAATATTTGGTGACATGTTGTCTTTTTGTCCTGTAGATTGTCATATCTGTTATGTAGTTATCCTTTTGGCAAGTCC
TTTGATTTTTTTTTCCTCTAGAAAATCCTCAGACTGTCAATCTTCCATATTTTGAATATTATAATGCTGTGGCCATTTCTATAGAAAGAT
TACTTGCAAGTGTGTGTCTTGAAAATAACCTCTTGTATTTGTGTGTTTATGTGAGTTCTGTCTAAGAGATCAGATAAGCTCTGGAAGCTT
CATCATCTGTACCTACATGTAACTGTATCTGGGTTACATGGGCAGGCGGTACCAAGTCCTGCTCTTCGATGGGGTGGCTGAGAGATAAAG
GTTCCTGAACTCTCCTTGCTGTGTATGCACCACATCTGTACTTCAGAGAGGTGGAAAATCATCTACAACACTGCGTTTCTTGTGGTTGTG
CTGTTACTGGTATAAAGTCAAGTGCCTTCAATGCTAAAGGCTCAGAAATTTTTCTTAAACTGATTTCATGTCCTATGCAAGTGTTTTCTA
CAACCTGCATAACCAGTACTTTGTAAAACTTGTTTACGCTTCAATTGTACATAGTGATTTTTAAAGAAATATATAGTATTTTTATTTAGG
TACCTCCAAACTTGAATTCGTCTGTGTGAAGCATTGTAAAACGATACATTTCTCTTTTGAGTACCATTACAGTTGTACAGAGGTTTTCAC
TGCTTCTATTTTTCTACTGTTACTGATAAGCATGTAACACTGACTTTATCCTACATATAGTTGGCATTTCAAATAAATGGCTTGTATAGA

>40651_40651_7_ITPK1-BTBD7_ITPK1_chr14_93542939_ENST00000556603_BTBD7_chr14_93730339_ENST00000334746_length(amino acids)=773AA_BP=28
MAEREENQEAEFPGLRRAVQEARDGGCAGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLT
AIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKR
GLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQ
QISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFG
DESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPK
AGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQ
SVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGLK
SAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACS

--------------------------------------------------------------
>40651_40651_8_ITPK1-BTBD7_ITPK1_chr14_93542939_ENST00000556603_BTBD7_chr14_93730339_ENST00000554565_length(transcript)=2718nt_BP=241nt
GCGGGCAGGGGCGGCGAGTGCGCGGGCGCTCGCCGCCGCCCTTCTCGGCGGGCAGCGCGCGAGGACCAGGCCGAGGAGGAAGTGGCGGCG
GCGGCGGCGGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAA
GAAGCTGAATTTCCAGGCCTTCGCCGAGCTGTGCAGGAAGCGAGGGATGGAGGTTGTGCAGGCTGTGAGGATATCATTGCTGAGAGCATC
TCATTAGATACCTTAATTGCCATCCTCAAGTGGAGTTCTCATCCATATGGCTCTAAATGGGTGCACCGACAAGCTTTACATTTCCTCTGT
GAGGAATTTTCCCAGGTCATGACTTCGGATGTTTTTTATGAACTCAGCAAAGACCATCTGCTTACTGCTATCCAGTCTGACTACCTACAG
GCAAGTGAACAAGATATCCTTAAATATCTGATTAAATGGGGAGAGCATCAGTTGATGAAAAGAATAGCAGATAGAGAGCCAAACTTACTG
AGTGGCACTGCCCATAGTGTGAACAAAAGAGGTGTAAAAAGACGGGACCTGGACATGGAAGAGCTCAGAGAGATCCTTTCTTCTCTCTTA
CCTTTTGTGCGAATTGAACACATCTTACCTATAAACAGTGAAGTCTTAAGTGATGCAATGAAAAGAGGCTTGATTAGTACTCCTCCATCA
GATATGCTTCCTACAACAGAAGGTGGGAAGTCAAATGCCTGGTTACGGCAAAAAAATGCTGGCATCTATGTTCGTCCTCGACTCTTCTCT
CCCTATGTGGAAGAAGCAAAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAAT
GTGCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGC
CCTCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACG
GAGCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGT
CTTGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATG
AGACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCC
TTGCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAG
CACCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTG
CCGAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCA
ACAGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGT
GTGTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGG
CCTCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAA
AATCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCT
TCGCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACG
TCTCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTG
GATGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGA
ACTGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCC
GGTAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGG
AGGTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCC
CATTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTG
TATATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTA

>40651_40651_8_ITPK1-BTBD7_ITPK1_chr14_93542939_ENST00000556603_BTBD7_chr14_93730339_ENST00000554565_length(amino acids)=773AA_BP=28
MAEREENQEAEFPGLRRAVQEARDGGCAGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLT
AIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKR
GLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQ
QISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFG
DESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPK
AGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQ
SVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGLK
SAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACS

--------------------------------------------------------------
>40651_40651_9_ITPK1-BTBD7_ITPK1_chr14_93542940_ENST00000556603_BTBD7_chr14_93730339_ENST00000334746_length(transcript)=7201nt_BP=241nt
GCGGGCAGGGGCGGCGAGTGCGCGGGCGCTCGCCGCCGCCCTTCTCGGCGGGCAGCGCGCGAGGACCAGGCCGAGGAGGAAGTGGCGGCG
GCGGCGGCGGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAA
GAAGCTGAATTTCCAGGCCTTCGCCGAGCTGTGCAGGAAGCGAGGGATGGAGGTTGTGCAGGCTGTGAGGATATCATTGCTGAGAGCATC
TCATTAGATACCTTAATTGCCATCCTCAAGTGGAGTTCTCATCCATATGGCTCTAAATGGGTGCACCGACAAGCTTTACATTTCCTCTGT
GAGGAATTTTCCCAGGTCATGACTTCGGATGTTTTTTATGAACTCAGCAAAGACCATCTGCTTACTGCTATCCAGTCTGACTACCTACAG
GCAAGTGAACAAGATATCCTTAAATATCTGATTAAATGGGGAGAGCATCAGTTGATGAAAAGAATAGCAGATAGAGAGCCAAACTTACTG
AGTGGCACTGCCCATAGTGTGAACAAAAGAGGTGTAAAAAGACGGGACCTGGACATGGAAGAGCTCAGAGAGATCCTTTCTTCTCTCTTA
CCTTTTGTGCGAATTGAACACATCTTACCTATAAACAGTGAAGTCTTAAGTGATGCAATGAAAAGAGGCTTGATTAGTACTCCTCCATCA
GATATGCTTCCTACAACAGAAGGTGGGAAGTCAAATGCCTGGTTACGGCAAAAAAATGCTGGCATCTATGTTCGTCCTCGACTCTTCTCT
CCCTATGTGGAAGAAGCAAAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAAT
GTGCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGC
CCTCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACG
GAGCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGT
CTTGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATG
AGACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCC
TTGCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAG
CACCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTG
CCGAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCA
ACAGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGT
GTGTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGG
CCTCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAA
AATCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCT
TCGCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACG
TCTCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTG
GATGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGA
ACTGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCC
GGTAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGG
AGGTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCC
CATTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTG
TATATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTA
TGTCGGGAGGCATTTTTAAGAACAAGCAGGCTGGCACTTTTTATTTCTCTTTACAAATGATGGAATTTTTTTGCACTTGTACATTTATTT
TCTCTGTATTGATTTTATATCAGTATGTTAAACTTTATTGCCACATTTAAAGGACTGTATTTTCATACTTTTTTGCATTTTACCTTTCAT
CTACCAATCCATGTGCATTGGATTGCACACTAAGATGTATTTTCTTACGAAATAGTTCTGTGTTTATTTTTTAATTATAGAAATTCCAAA
GAACAGCACATCAGAATGCTCCTCTCTTTTCAGTAATTGTTTTAGTTCAGAGATCTTCCCGCTCAGCCTCCATAAATCTAATGTCATTTT
TTTTTTAATAAGTCCTAGGAGCTGGGCTTCATTCCTCCAGCGGGAGTCCAGTCAGGGTCCTGAAGTTTGCTGGTTCAGGAAAGAACAGGA
AAGAGAAAAGCCTTCTGTGCCCAGGCTAAAGCTGTTACATTTCCACAGTGTGGATGCAGTCAGAATCCCTGCACATTCTGGTCATAAGGA
TTAGAGTCACCAGATGAGGCTCTAAACAGATCGCATCCCTTGGAATTAGAAAGCAGTGGAGACCGGGCGCAGTGACTCACACCTGTGATC
GGCACTTCGGAAGGCCGAGGCGGGCAGATCACTGAAGCTCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACTCCATTTCTATAAA
AAATACAAAAAAAAAAAAATCTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGGGGCTGAGGTGGCAGGATCGCTTGA
GCCTGGGAGGTTGAGACTGCAGTGAGCCAAGATTGCACCACTGTGCTCCCACCTGGGCAACAGTGAGACCCTGTCTCAAAAAAAAAAAAA
AAGGCAGTGGAAATAGAGAAGTAACTTAAAGGTCACACTGACAGAATTTCTGGTTCTGAGCGTCAACTCTCCAGCTGTGATGGCGGAACT
GACTGCTTGCTGCCTTTAATTGTCTTGCTCTCTATGGGAAAAAAACAAAAGGGCTTCAGTCTCATGGATGTTATTTGGTGTTTGTAAAGA
TACGTTTTCTTTTAAACGATTTTCAAAATATGTCTAAATTTTGGTGTTGTGTAATGCATAATGCTTTCTCACCAACAGAAAAAAGGAAAA
AAATTGTTTTCAGTTAAACACTACATGTCCTACTTGAACTCCACTGGGACGCTGGTTTGGCATTTACTAAACCACTGAGCACATGGGGTC
TTTCAGGATCCTCTCCCTTGGAAGGGCAATGTGTGAGCTAAGGACTGTTTTTTTTCTTACTCTCCAATGTAAATATATGAGTATTTGAGT
TTTTAAATCACTTCAACATTATTTGAGCATTTACTTTGTATTTTTACAAACACATAAACACACAGCCGTAGCACTTAGAAGAAAAGAGGC
TTTCTAAGCATTCCTTCCTCTGCAGGATATTTGGGATCCTCTTTTCTATGTATGTATATATATAAAAAACTATGAATCACTCACACTCAC
TCGAAAACTATGCAGGGCTAGGGAGCGTTTATGAGCTACCGGGTAAATGAATTACATGCACTTTGAAGTAAATAGGTTTTCTATTGGGTG
TCAACAACGCTGATTTCTCCCAAAACTATAGTTTCTCTTACGGTCTTTTCCTCCTTTACCCTGTGGATATACACTCAGGAATAATCTGAC
ATTTTAGAAAAGCCGAACAGTAGATAGTCTCCAAGATGGGAAACATGTCGTGTGTCTGCACGCCCCGGCAAACTGCCGCCACTCGTTCTG
CTGCCTGACTGGTTAGCTGCTGTGCGGGTGCGCTCGGTGACACTGGTGGTGGTGCACGCTCCCGAGCTCCCAGAGTTAACACTAATCTGC
AGGTCGGCTGTGCATCGCATTCGAGGCTCCTTTTTTAAAGAGAAAAGCATAGGCCTCTGTTCTCATTTGTAAGAAGTTTGACTCATAATA
GAAGACGGTGTCTTTTGAAGCCCAGTCTCTGTCTGTCTTCAGAAACAAAAGTGAATGCCGTCATGTTCCTTGATGTGTGTTTCTGCCACA
TATGTATGTTGACATGTTCATGTACTGCGCCGGTACTGCAAGTAAGACTCAACAGACCTAATTTGGATGGGGAGAAAAACTCTCATCCCT
GACCCTTCCCCCCCCGCAAATGTTAGACCAGAGCTGTTGATCCCACACATTCATTTTTCTGAAAATTCATGAACTATTCTCTCATATCCC
TGAAATATAAAAGTAAGTGGCCACTATTCCTAAGATTATTTAGTTTATAAAGTTTGCTTTTAATCATACAATAGCTTACCTGGCTAAAAC
TTTGCGTATAAAGGGAAAACTTGCTTTAATCTGTGGGATTGCGGACCGATGCGACTTGCAGAAGGTAAACAGGCGTGGGTTTTGTGTGCG
TTAGGTTAGGTGTTAGTGGACTTTTAATGTATCTTGTGAAGTATGGTTACTAGGGTAGGTTCAAGAGCTACATGCCTCTGGCTTTTGAAC
CCATCTATTAAATCTTTTTTAATGCTGTACTAAGATAAATGTGAAGTCTGAGTAAGGTTGCTCTCAGAAAAAAAAAAAAAGCATATATAT
ATATAAAATAAAATTTAGGCCATGGGAACTGGCATTTTACTTGGTATAGGAATTTAATGAGAACCAAATCACAAAAATACCAGATCTCCT
TTTGAGATCGTGGACAATCAGGCCTTTGGACAATCACCGCTTCCAGTGCCCGCTGTGCGTTGAGGTTAGAGACCTACCGTTTACACGCTA
GAGCCGAGAGGACGTTCAAGTTTCTTAAAGATGCTGTTGGTCTTTTTTCTTATGTTATTGTTTTAGTTTTGTGATTTTGATGAATAATTG
AAGTTCAGAGTCACCCGTGGCTCCTAAGGAAAAAACAGCATCATGAAAGGCAAAAAGTATTTGAAACGTAATTGTTTCAATTTTCCACGC
CCGTTCTCACATGCCCCCTTTAGCTTTATTTCTGGGAACATGTCACTAGACCTCAGCTAGCCTGACACCGCAATAACCCGTTAGGCTTTG
AGGCTTTTCAGTGAATTCTTGACATTTAAATCTTCTTATAGAATTCTTTATGAAGCCTTAACTAATTCTTGTTTTTGCTTCCTCAGAAAC
TTTTTATTGCATCTGCCATCCTTCATTGGATTTTTGTTTTGGTTTGTTGTTGCCATTCTAGCAATGAGCTTAGTCCTTGTACATCTGCAT
TAAGGTGCCGATGCAGAAGGCAAATTGGAAACACGCGCCAGCGGCAGTGGGGCTCAAAGCCGACCTCCATGCATCATTCTCTAGAGTTGA
AAGGATTGACATTTCTCAGTAACTACCCGGCAAAATATATATTTTCATAATGTTGAATTTGCCTTTTAGGAAAACAATGTTTCATGAAAC
ACTTGTAAGATACTTATTTTGAAATTAATTATAAGGCATTCATATTTTTAGGACTGAATTCAAAGGGAAATGCTTCTTTGACTTTTTTTC
ATTGTTCGGTTGACTTTCAGCTTTCTGGAGTGACAAAGCAGCAGTGATGGGTGCTATTCCTGGTTCTGTGGTGGTTTACTTTGTCTACTA
AGTGATTTACTTTCAAACCTCATTACAGATAATCTTACTAAAAGACTTAACATGCACACTGCTAAAAGGTGTTTTACTGTTTTCCATTAA
CGCTGTTGTATGAACAATATTTGGTGACATGTTGTCTTTTTGTCCTGTAGATTGTCATATCTGTTATGTAGTTATCCTTTTGGCAAGTCC
TTTGATTTTTTTTTCCTCTAGAAAATCCTCAGACTGTCAATCTTCCATATTTTGAATATTATAATGCTGTGGCCATTTCTATAGAAAGAT
TACTTGCAAGTGTGTGTCTTGAAAATAACCTCTTGTATTTGTGTGTTTATGTGAGTTCTGTCTAAGAGATCAGATAAGCTCTGGAAGCTT
CATCATCTGTACCTACATGTAACTGTATCTGGGTTACATGGGCAGGCGGTACCAAGTCCTGCTCTTCGATGGGGTGGCTGAGAGATAAAG
GTTCCTGAACTCTCCTTGCTGTGTATGCACCACATCTGTACTTCAGAGAGGTGGAAAATCATCTACAACACTGCGTTTCTTGTGGTTGTG
CTGTTACTGGTATAAAGTCAAGTGCCTTCAATGCTAAAGGCTCAGAAATTTTTCTTAAACTGATTTCATGTCCTATGCAAGTGTTTTCTA
CAACCTGCATAACCAGTACTTTGTAAAACTTGTTTACGCTTCAATTGTACATAGTGATTTTTAAAGAAATATATAGTATTTTTATTTAGG
TACCTCCAAACTTGAATTCGTCTGTGTGAAGCATTGTAAAACGATACATTTCTCTTTTGAGTACCATTACAGTTGTACAGAGGTTTTCAC
TGCTTCTATTTTTCTACTGTTACTGATAAGCATGTAACACTGACTTTATCCTACATATAGTTGGCATTTCAAATAAATGGCTTGTATAGA

>40651_40651_9_ITPK1-BTBD7_ITPK1_chr14_93542940_ENST00000556603_BTBD7_chr14_93730339_ENST00000334746_length(amino acids)=773AA_BP=28
MAEREENQEAEFPGLRRAVQEARDGGCAGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLT
AIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKR
GLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQ
QISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFG
DESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPK
AGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQ
SVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGLK
SAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACS

--------------------------------------------------------------
>40651_40651_10_ITPK1-BTBD7_ITPK1_chr14_93542940_ENST00000556603_BTBD7_chr14_93730339_ENST00000554565_length(transcript)=2718nt_BP=241nt
GCGGGCAGGGGCGGCGAGTGCGCGGGCGCTCGCCGCCGCCCTTCTCGGCGGGCAGCGCGCGAGGACCAGGCCGAGGAGGAAGTGGCGGCG
GCGGCGGCGGGCTCCCCGCCCGAGGAGGAAGATGCAGACCTTTCTGAAAGGGAAGAGAGTTGGCTACTGGCTGAGCGAGAAGAAAATCAA
GAAGCTGAATTTCCAGGCCTTCGCCGAGCTGTGCAGGAAGCGAGGGATGGAGGTTGTGCAGGCTGTGAGGATATCATTGCTGAGAGCATC
TCATTAGATACCTTAATTGCCATCCTCAAGTGGAGTTCTCATCCATATGGCTCTAAATGGGTGCACCGACAAGCTTTACATTTCCTCTGT
GAGGAATTTTCCCAGGTCATGACTTCGGATGTTTTTTATGAACTCAGCAAAGACCATCTGCTTACTGCTATCCAGTCTGACTACCTACAG
GCAAGTGAACAAGATATCCTTAAATATCTGATTAAATGGGGAGAGCATCAGTTGATGAAAAGAATAGCAGATAGAGAGCCAAACTTACTG
AGTGGCACTGCCCATAGTGTGAACAAAAGAGGTGTAAAAAGACGGGACCTGGACATGGAAGAGCTCAGAGAGATCCTTTCTTCTCTCTTA
CCTTTTGTGCGAATTGAACACATCTTACCTATAAACAGTGAAGTCTTAAGTGATGCAATGAAAAGAGGCTTGATTAGTACTCCTCCATCA
GATATGCTTCCTACAACAGAAGGTGGGAAGTCAAATGCCTGGTTACGGCAAAAAAATGCTGGCATCTATGTTCGTCCTCGACTCTTCTCT
CCCTATGTGGAAGAAGCAAAGTCAGTGCTAGATGAGATGATGGTGGAACAAACGGATCTTGTGCGCTTGCGAATGGTTAGAATGTCCAAT
GTGCCAGACACGCTCTACATGGTCAATAATGCCGTGCCACAGTGTTGTCACATGATCAGCCACCAGCAGATCAGCAGCAACCAGTCAAGC
CCTCCTTCAGTTGTAGCCAACGAAATTCCAGTTCCTCGTCTCCTCATTATGAAAGACATGGTCAGACGACTGCAGGAACTGCGGCACACG
GAGCAGGTGCAGAGGGCCTATGCCCTGAACTGCGGGGAAGGCGCCACTGTCAGCTATGAAATTCAGATTCGAGTGCTAAGAGAGTTTGGT
CTTGCAGATGCTGCTGCAGAGCTGTTGCAGAATCCTCACAAATTCTTTCCTGATGAACGTTTTGGGGATGAAAGTCCACTCTTGACAATG
AGACAGCCTGGGAGATGTCGCGTAAACAGTACACCTCCTGCAGAAACCATGTTTACAGATCTGGACTCTTTTGTGGCCTTCCATCCACCC
TTGCCCCCTCCACCACCTCCCTACCACCCCCCAGCTACCCCAATCCATAACCAACTCAAAGCAGGCTGGAAGCAAAGACCTCCCAGTCAG
CACCCTTCACGTTCATTTTCTTATCCCTGTAATCATTCGCTGTTCCACTCCAGAACAGCTCCTAAAGCTGGCCCTCCCCCAGTCTACTTG
CCGAGTGTGAAAGCTGCACCGCCTGATTGTACCAGCACTGCAGGACTGGGCAGACAGACGGTGGCTGCTGCTGCCGCCACCACCACCTCA
ACAGCAACAGCAGCAGCAGCAGCAGCATCTGAGAAGCAAGTGCGAACACAACCTGTGCTGAATGATCTGATGCCAGACATCGCGGTGGGT
GTGTCCACACTGTCACTCAAGGACAGGAGGCTTCCAGAGCTTGCTGTAGACACAGAATTAAGCCAGTCAGTTTCTGAAGCAGGACCAGGG
CCTCCCCAGCATCTGTCGTGTATTCCACAGAGACATACACACACTTCTCGGAAAAAACACACACTAGAGCAAAAAACAGACACCAGAGAA
AATCCACAGGAATATCCGGATTTCTATGACTTCTCAAATGCTGCTTGCAGACCTTCTACTCCTGCTCTCAGCAGACGCACCCCTTCCCCT
TCGCAAGGTGGATATTTTGGTCCCGATCTGTACAGCCACAATAAGGCATCACCAAGTGGCTTAAAGTCAGCCTACCTACCTGGTCAGACG
TCTCCTAAAAAACAGGAAGAAGCTAGGAGAGAATATCCACTTTCCCCTGACGGGCATCTACACAGACAAAAGAATGAGCCGATACACCTG
GATGTCGTTGAGCAACCTCCCCAGCGGTCAGACTTTCCTTTGGCAGCCCCAGAAAATGCTAGTACCGGTCCAGCCCATGTCAGGGGACGA
ACTGCAGTAGAAACTGACTTGACTTTTGGGCTGACTCCTAACAGACCTTCACTTTCTGCATGTAGCTCTGAAGCTCCCGAAGAGAGATCC
GGTAGAAGACTGGCAGACAGTGAGTCCCTGGGCCATGGAGCTCAGAGAAATACAGATTTGGAAAGGGAAGATTCAATAAGCAGAGGAAGG
AGGTCACCAAGCAAGCCGGACTTCCTCTACAAAAAGTCTGCCCTCTGAGAGCAACCTCCAAGTCGTCTGTGCCTGAGATGTGAAACATCC
CATTTTATGATGTAACCCAACAACTTACAGACCAGTTCATCAATGCCAGCTGATAACTCGGTTTCACATGATTTTGTTCTAGTTTTTGTG
TATATATGTGTTTATTAGACATGGCATGCTAAGAAGGTTTTGTTTTTTTTTTTTAATGTTGCATCTGTCTAATTTGTCTTTGAACAATTA

>40651_40651_10_ITPK1-BTBD7_ITPK1_chr14_93542940_ENST00000556603_BTBD7_chr14_93730339_ENST00000554565_length(amino acids)=773AA_BP=28
MAEREENQEAEFPGLRRAVQEARDGGCAGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLT
AIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKR
GLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQ
QISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFG
DESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPK
AGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQ
SVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGLK
SAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ITPK1-BTBD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITPK1-BTBD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITPK1-BTBD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource