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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ITPR1-BHLHE40 (FusionGDB2 ID:40677)

Fusion Gene Summary for ITPR1-BHLHE40

Fusion gene summary

Fusion gene information	Fusion gene name: ITPR1-BHLHE40
	Fusion gene ID: 40677
		Hgene	Tgene
	Gene symbol	ITPR1	BHLHE40
	Gene ID	3708	8553
	Gene name	inositol 1,4,5-trisphosphate receptor type 1	basic helix-loop-helix family member e40
	Synonyms	ACV\|CLA4\|INSP3R1\|IP3R\|IP3R1\|PPP1R94\|SCA15\|SCA16\|SCA29	BHLHB2\|Clast5\|DEC1\|HLHB2\|SHARP-2\|SHARP2\|STRA13\|Stra14
	Cytomap	3p26.1	3p26.1
	Type of gene	protein-coding	protein-coding
	Description	inositol 1,4,5-trisphosphate receptor type 1IP3 receptorIP3R 1inositol 1,4,5-triphosphate receptor, type 1protein phosphatase 1, regulatory subunit 94type 1 InsP3 receptortype 1 inositol 1,4,5-trisphosphate receptor	class E basic helix-loop-helix protein 40basic helix-loop-helix domain containing, class B, 2class B basic helix-loop-helix protein 2differentially expressed in chondrocytes 1differentially expressed in chondrocytes protein 1differentiated embryo cho
	Modification date	20200327	20200327
	UniProtAcc	Q14643	O14503
	Ensembl transtripts involved in fusion gene	ENST00000302640, ENST00000354582, ENST00000357086, ENST00000423119, ENST00000443694, ENST00000456211, ENST00000463980, ENST00000544951,	ENST00000256495,
Fusion gene scores	* DoF score	14 X 15 X 8=1680	3 X 4 X 3=36
	# samples	16	4
	** MAII score	log2(16/1680*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ITPR1 [Title/Abstract] AND BHLHE40 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ITPR1(4704890)-BHLHE40(5023077), # samples:2 ITPR1(4808394)-BHLHE40(5024521), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITPR1	GO:0001666	response to hypoxia	19120137
Hgene	ITPR1	GO:0050849	negative regulation of calcium-mediated signaling	16793548
Tgene	BHLHE40	GO:0000122	negative regulation of transcription by RNA polymerase II	12397359\|12624110\|14672706\|15193144
Tgene	BHLHE40	GO:0007623	circadian rhythm	28797635
Tgene	BHLHE40	GO:0032922	circadian regulation of gene expression	18411297
Tgene	BHLHE40	GO:0043433	negative regulation of DNA-binding transcription factor activity	18411297
Tgene	BHLHE40	GO:0045892	negative regulation of transcription, DNA-templated	12397359\|30012868

Fusion gene breakpoints across ITPR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BHLHE40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-A7TA-01A	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
ChimerDB4	LGG	TCGA-DU-A7TA	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
ChimerDB4	UCEC	TCGA-D1-A3DH-01A	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+

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Fusion Gene ORF analysis for ITPR1-BHLHE40

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000302640	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000302640	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
In-frame	ENST00000354582	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000354582	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
In-frame	ENST00000357086	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000357086	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
In-frame	ENST00000423119	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000423119	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
In-frame	ENST00000443694	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000443694	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
In-frame	ENST00000456211	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
In-frame	ENST00000456211	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
intron-3CDS	ENST00000463980	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
intron-3CDS	ENST00000463980	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+
intron-3CDS	ENST00000544951	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+
intron-3CDS	ENST00000544951	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000302640	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4471	1859	305	2839	844
ENST00000354582	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4516	1904	305	2884	859
ENST00000423119	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4516	1904	305	2884	859
ENST00000456211	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4469	1857	303	2837	844
ENST00000357086	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4514	1902	303	2882	859
ENST00000443694	ITPR1	chr3	4704890	+	ENST00000256495	BHLHE40	chr3	5023077	+	4121	1509	0	2489	829
ENST00000302640	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8518	6030	305	6886	2193
ENST00000354582	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8518	6030	305	6886	2193
ENST00000423119	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8419	5931	305	6787	2160
ENST00000456211	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8372	5884	303	6740	2145
ENST00000357086	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8417	5929	303	6785	2160
ENST00000443694	ITPR1	chr3	4808394	+	ENST00000256495	BHLHE40	chr3	5024521	+	8168	5680	0	6536	2178

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000302640	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000562989	0.99943703
ENST00000354582	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000422285	0.9995777
ENST00000423119	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000422285	0.9995777
ENST00000456211	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000550547	0.99944943
ENST00000357086	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000412742	0.99958724
ENST00000443694	ENST00000256495	ITPR1	chr3	4704890	+	BHLHE40	chr3	5023077	+	0.000537878	0.9994622
ENST00000302640	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.001413369	0.99858665
ENST00000354582	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.001350467	0.99864954
ENST00000423119	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.00154008	0.99845994
ENST00000456211	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.001476718	0.9985233
ENST00000357086	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.00152498	0.998475
ENST00000443694	ENST00000256495	ITPR1	chr3	4808394	+	BHLHE40	chr3	5024521	+	0.001050922	0.9989491

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Fusion Genomic Features for ITPR1-BHLHE40

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ITPR1	chr3	4704890	+	BHLHE40	chr3	5023076	+	0.13115934	0.8688407
ITPR1	chr3	4704890	+	BHLHE40	chr3	5023076	+	0.13115934	0.8688407
ITPR1	chr3	4808394	+	BHLHE40	chr3	5024520	+	0.000167455	0.9998325
ITPR1	chr3	4704890	+	BHLHE40	chr3	5023076	+	0.13115934	0.8688407
ITPR1	chr3	4704890	+	BHLHE40	chr3	5023076	+	0.13115934	0.8688407
ITPR1	chr3	4808394	+	BHLHE40	chr3	5024520	+	0.000167455	0.9998325

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITPR1-BHLHE40

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:4704890/chr3:5023077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITPR1 Q14643	BHLHE40 O14503
FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250\|UniProtKB:P11881, ECO:0000269\|PubMed:27108797}.	FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1\|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269\|PubMed:12397359, ECO:0000269\|PubMed:14672706, ECO:0000269\|PubMed:15193144, ECO:0000269\|PubMed:15560782, ECO:0000269\|PubMed:18411297, ECO:0000269\|PubMed:19786558, ECO:0000269\|PubMed:28797635, ECO:0000269\|PubMed:30012868}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

112_166

503

2744.0

Domain

MIR 1

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

173_223

503

2744.0

Domain

MIR 2

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

231_287

503

2744.0

Domain

MIR 3

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

294_373

503

2744.0

Domain

MIR 4

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

379_435

503

2744.0

Domain

MIR 5

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

112_166

518

2711.0

Domain

MIR 1

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

173_223

518

2711.0

Domain

MIR 2

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

231_287

518

2711.0

Domain

MIR 3

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

294_373

518

2711.0

Domain

MIR 4

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

379_435

518

2711.0

Domain

MIR 5

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

112_166

503

2744.0

Domain

MIR 1

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

173_223

503

2744.0

Domain

MIR 2

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

231_287

503

2744.0

Domain

MIR 3

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

294_373

503

2744.0

Domain

MIR 4

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

379_435

503

2744.0

Domain

MIR 5

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

112_166

503

2696.0

Domain

MIR 1

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

173_223

503

2696.0

Domain

MIR 2

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

231_287

503

2696.0

Domain

MIR 3

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

294_373

503

2696.0

Domain

MIR 4

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

379_435

503

2696.0

Domain

MIR 5

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

112_166

1893

2744.0

Domain

MIR 1

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

173_223

1893

2744.0

Domain

MIR 2

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

231_287

1893

2744.0

Domain

MIR 3

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

294_373

1893

2744.0

Domain

MIR 4

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

379_435

1893

2744.0

Domain

MIR 5

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

112_166

1860

2711.0

Domain

MIR 1

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

173_223

1860

2711.0

Domain

MIR 2

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

231_287

1860

2711.0

Domain

MIR 3

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

294_373

1860

2711.0

Domain

MIR 4

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

379_435

1860

2711.0

Domain

MIR 5

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

112_166

1893

2744.0

Domain

MIR 1

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

173_223

1893

2744.0

Domain

MIR 2

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

231_287

1893

2744.0

Domain

MIR 3

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

294_373

1893

2744.0

Domain

MIR 4

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

379_435

1893

2744.0

Domain

MIR 5

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

112_166

1845

2696.0

Domain

MIR 1

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

173_223

1845

2696.0

Domain

MIR 2

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

231_287

1845

2696.0

Domain

MIR 3

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

294_373

1845

2696.0

Domain

MIR 4

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

379_435

1845

2696.0

Domain

MIR 5

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

265_269

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

265_269

518

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

508_511

518

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

265_269

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

265_269

503

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

265_269

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

508_511

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

567_569

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

265_269

1860

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

508_511

1860

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

567_569

1860

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

265_269

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

508_511

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

567_569

1893

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

265_269

1845

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

508_511

1845

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

567_569

1845

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

BHLHE40

chr3:4704890

chr3:5023077

ENST00000256495

142_175

413.0

Domain

Orange

Tgene

BHLHE40

chr3:4808394

chr3:5024521

ENST00000256495

142_175

127

413.0

Domain

Orange

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

508_511

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

567_569

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

567_569

518

2711.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

508_511

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

567_569

503

2744.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

508_511

503

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

567_569

503

2696.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

1_2282

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2304_2314

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2336_2361

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2383_2405

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2427_2448

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2470_2577

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2599_2758

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

1_2282

518

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2304_2314

518

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2336_2361

518

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2383_2405

518

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2427_2448

518

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2470_2577

518

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2599_2758

518

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

1_2282

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2304_2314

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2336_2361

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2383_2405

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2427_2448

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2470_2577

503

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2599_2758

503

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

1_2282

503

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2304_2314

503

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2336_2361

503

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2383_2405

503

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2427_2448

503

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2470_2577

503

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2599_2758

503

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

1_2282

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2304_2314

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2336_2361

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2383_2405

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2427_2448

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2470_2577

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2599_2758

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

1_2282

1860

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2304_2314

1860

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2336_2361

1860

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2383_2405

1860

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2427_2448

1860

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2470_2577

1860

2711.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2599_2758

1860

2711.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

1_2282

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2304_2314

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2336_2361

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2383_2405

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2427_2448

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2470_2577

1893

2744.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2599_2758

1893

2744.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

1_2282

1845

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2304_2314

1845

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2336_2361

1845

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2383_2405

1845

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2427_2448

1845

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2470_2577

1845

2696.0

Topological domain

Lumenal

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2599_2758

1845

2696.0

Topological domain

Cytoplasmic

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2283_2303

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2315_2335

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2362_2382

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2406_2426

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2449_2469

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000302640

2578_2598

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2283_2303

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2315_2335

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2362_2382

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2406_2426

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2449_2469

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000357086

2578_2598

518

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2283_2303

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2315_2335

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2362_2382

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2406_2426

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2449_2469

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000443694

2578_2598

503

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2283_2303

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2315_2335

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2362_2382

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2406_2426

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2449_2469

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4704890

chr3:5023077

ENST00000456211

2578_2598

503

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2283_2303

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2315_2335

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2362_2382

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2406_2426

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2449_2469

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000302640

2578_2598

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2283_2303

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2315_2335

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2362_2382

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2406_2426

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2449_2469

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000357086

2578_2598

1860

2711.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2283_2303

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2315_2335

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2362_2382

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2406_2426

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2449_2469

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000443694

2578_2598

1893

2744.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2283_2303

1845

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2315_2335

1845

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2362_2382

1845

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2406_2426

1845

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2449_2469

1845

2696.0

Transmembrane

Helical

Hgene

ITPR1

chr3:4808394

chr3:5024521

ENST00000456211

2578_2598

1845

2696.0

Transmembrane

Helical

Tgene

BHLHE40

chr3:4704890

chr3:5023077

ENST00000256495

52_107

413.0

Domain

bHLH

Tgene

BHLHE40

chr3:4808394

chr3:5024521

ENST00000256495

52_107

127

413.0

Domain

bHLH

Top

Fusion Gene Sequence for ITPR1-BHLHE40

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40677_40677_1_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000302640_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4471nt_BP=1859nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAG
AAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTG
ACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGG
AAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTG
AAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATG
AAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCT
TCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGACTTTGGGTCACTTGGAAAAAGCAGTGGTTC
TTGAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTGATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTTTACAAG
CTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATC
TGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTA
CCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGA
AAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAG
GAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCG
CAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGA
TCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGC
CCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGA
ACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGC
TCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGC
TACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAG
ATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCT
TTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGA
ATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGT
GGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGT
CGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGG
TAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAG
TGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACC
TGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGT
GCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGC
TTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTG
CTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCT
TTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTG
TAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTG
AGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTC
CTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTG
GAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAA

>40677_40677_1_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000302640_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=844AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEKAVVLELTLKHVKALT
NLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKV
MDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTK
KNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMP

--------------------------------------------------------------
>40677_40677_2_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000354582_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4516nt_BP=1904nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGG
ACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACA
TCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTAT
GTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGA
AGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGG
GCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCG
TCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGA
ATATTCTCAAGCAGACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTTGAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTG
ATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTTTACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGT
TCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTG
TCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCA
AGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTG
GGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCA
AAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGA
TGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCT
GCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTAT
ACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCC
CTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAG
ACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGA
TTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGC
GTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACT
TGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAA
AGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTC
AGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGA
GCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCC
TCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCT
GAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAA
CCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGAC
TCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTG
TAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCC
AGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTT
TCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAA
AATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTT
TTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTT
AAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGG
TGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCTCAGTGTAATTTCATTCAGCTTTTCATGTGCTTT

>40677_40677_2_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000354582_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=859AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEK
AVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELL
QGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGE
RIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALS

--------------------------------------------------------------
>40677_40677_3_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000357086_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4514nt_BP=1902nt
AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG
GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC
ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA
GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA
ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT
GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC
CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC
GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG
CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT
GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG
AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC
AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT
GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT
GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT
TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGGAC
CCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATC
TCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGT
ACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAG
GAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGC
TCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTC
ACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAAT
ATTCTCAAGCAGACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTTGAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTGAT
CAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTTTACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTC
TGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTC
ACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAG
GAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGG
GAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAA
AGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATG
CAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGC
CTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATAC
CCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCT
TCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGAC
TAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATT
GTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGT
GCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTG
GGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAG
TCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAG
CTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGC
TTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTC
GGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGA
GCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACC
AAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTC
AGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTA
GGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAG
AGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTC
TTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAA
TGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTT
TTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAA
GTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTG
TGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCTCAGTGTAATTTCATTCAGCTTTTCATGTGCTTTGT

>40677_40677_3_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000357086_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=859AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEK
AVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELL
QGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGE
RIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALS

--------------------------------------------------------------
>40677_40677_4_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000423119_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4516nt_BP=1904nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGG
ACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACA
TCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTAT
GTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGA
AGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGG
GCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCG
TCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGA
ATATTCTCAAGCAGACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTTGAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTG
ATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTTTACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGT
TCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTG
TCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCA
AGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTG
GGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCA
AAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGA
TGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCT
GCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTAT
ACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCC
CTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAG
ACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGA
TTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGC
GTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACT
TGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAA
AGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTC
AGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGA
GCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCC
TCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCT
GAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAA
CCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGAC
TCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTG
TAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCC
AGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTT
TCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAA
AATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTT
TTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTT
AAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGG
TGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCTCAGTGTAATTTCATTCAGCTTTTCATGTGCTTT

>40677_40677_4_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000423119_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=859AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEK
AVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELL
QGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGE
RIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALS

--------------------------------------------------------------
>40677_40677_5_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000443694_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4121nt_BP=1509nt
ATGTCTGACAAAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTG
GGCCTGGTTGATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTA
TGTCCCATGAACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAAC
AAACTGCACCACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTG
ATCCAGCTCCTGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACA
TTGGACGAGGCTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGAC
AAGGTGGTTCTGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAAT
TCCGTCAACTGCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTG
AGGCTGTTTCATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAG
TCGGCCACATCTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAAC
AGCCTTTTCCGTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGG
AATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTG
CGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCT
ATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTT
TCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATC
ACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTC
GAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGACTTTGGGTCACTTGGAAAAA
GCAGTGGTTCTTGAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTGATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGT
GGTTTACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTG
CTTCAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTG
CAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAA
GGTCCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGT
GGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAA
AGGATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGC
AGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACT
GCCTACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCT
AGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCT
TCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTT
CCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCA
TGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTT
TAAAGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCC
CACCCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAG
CTGGGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTG
CCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGG
CATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAG
GCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGC
TTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGC
ACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAAC
CAAGCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGT
GTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTC
CGCAGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTG
CCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGAT
TCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTT
TGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTC
TTTTCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTG

>40677_40677_5_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000443694_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=829AA_BP=0
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLN
KLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQ
SATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTL
RGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTI
TQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQS
GLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSE
GPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTS
SDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDS

--------------------------------------------------------------
>40677_40677_6_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000456211_BHLHE40_chr3_5023077_ENST00000256495_length(transcript)=4469nt_BP=1857nt
AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG
GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC
ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA
GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA
ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT
GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC
CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC
GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG
CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT
GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG
AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC
AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT
GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT
GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT
TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAA
AAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGAC
AGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAA
GAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAA
GTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAA
AGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTC
TCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTT
GAACTTACCTTGAAGCATGTGAAAGCACTAACAAACCTAATTGATCAGCAGCAGCAGAAAATCATTGCCCTGCAGAGTGGTTTACAAGCT
GGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTG
GCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACC
TCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAA
AACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGA
GAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCA
ATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATC
AGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCC
ATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAAC
CCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTC
CAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTA
CTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGAT
TCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTT
TGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAAT
AGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGG
CTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCG
ACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTA
GTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTG
ATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTG
TTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGC
ACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTT
CTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCT
AAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTT
TCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTA
AAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAG
AAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCT
GAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGA
AGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAAC

>40677_40677_6_ITPR1-BHLHE40_ITPR1_chr3_4704890_ENST00000456211_BHLHE40_chr3_5023077_ENST00000256495_length(amino acids)=844AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQTLGHLEKAVVLELTLKHVKALT
NLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKV
MDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTK
KNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMP

--------------------------------------------------------------
>40677_40677_7_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000302640_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8518nt_BP=6030nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAG
AAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTG
ACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGG
AAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTG
AAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATG
AAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCT
TCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAG
ACTGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACCAGCGGCACGCTCCTTTCAGACACATCTGCCGGCTCTGCTACAGGG
TGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATATAGCCAAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATG
TGTTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGAAACTCCTGGAAAAACACATTACCGCGGCAGAGATTGACACATTTG
TCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACCTCTCCGACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCC
AGGAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACATCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTTGAATTTGAAG
GTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACGAGGAAGAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTC
GCAGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGCAGAAGGAGGACCGAGACGTTCTCAGCTACTACAGATATCAGCTGA
ACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCAACGAAATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCA
TGTCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCCGCCTCATGCTTCACATGCATGTGGACCGAGATCCCCAGGAACAAG
TCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGGAGATCGCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATG
AAATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGTATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTCTCTGATAAAG
AGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATCTCATATACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAA
CTAAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAATCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAGAATAAAGGTA
ACAATGATGTGGAGAAGCTGAAGAGCAGTAACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCCAGGTGGTGCTCCGGGGAG
GAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCAATGTGAAGCAGGCAGAGCCTGAGAAGGAGGACATCATGGTCATGG
ACACCAAGCTGAAGATCATTGAGATACTCCAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCCTCCTGTGTATATTTAAGC
GAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCGGAAACAGCAGCCAAGAAGGGCCAAGTAATGTACCAGGTGCTCTTG
ACTTTGAACACATTGAAGAACAAGCAGAAGGCATCTTTGGAGGAAGTGAGGAGAACACCCCACTGGACTTGGATGACCACGGCGGCAGAA
CCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCACCCCTGGTGTCAGGGGCCCTGCAGCTCCTCTTCCGGCACTTCAGCC
AGAGGCAGGAGGTGCTCCAGGCCTTCAAACAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACAAACAGATCAAACAAGACT
TGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGTACAAAGGGCAGGGCCCCGATGAGACTATGGATGGTGCATCTGGAG
AAAATGAACATAAGAAAACGGAGGAGGGAAATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACTACAGAGTGGTCAAAGAGA
TTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAGTGAGAAAGAGCAGGAAGCAGCAACAGCGTCTGCTCCGGAACATGG
GCGCGCACGCCGTGGTGCTGGAGCTGCTGCAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGATAATGAGGTTGGCTCATG
AATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTTTGCTACATAAACACATAAACCTGTTTCTCAACCCAGGGATCCTGG
AGGCAGTAACCATGCAGCACATCTTCATGAACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTCAGCACTTCGTTCACTGCA
TAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGACAATTGTCAAGGCAGAAGGGAAATTTATTAAAAAATGCCAAGACA
TGGTTATGGCCGAGCTGGTCAATTCGGGAGAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGACTCTGATCCAGATGATGC
GGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACCACATCCACTTGGTCGAGCTCCTGGCTGTGTGCACGGAGGGTAAGA
ATGTCTACACAGAGATCAAGTGCAACTCCCTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGGACTGCATCCCTGAGGTTA
AAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAGAGGTGGAAATGAAGGAGATTTATACCAGCAATCACATGTGGAAAT
TGTTTGAGAATTTCCTTGTAGACATCTGCAGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGATTTTGGAGAAGTATGTCA
CCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCTTCTCAGACCAGAGTACGACTTTGCAGACTCGCCAGCCTGTCTTTG
TGCAACTGCTGCAAGGCGTGTTCAGGGTTTACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGGAGAGCTGTATTCGGGTGC
TGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACCTGGACAGCCAAGTCAACAACCTCTTTCTCAAGTCCCACAGCATTG
TGCAGAAAACAGCCATGAACTGGCGGCTCTCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTTCCAGAGACTACCGGAATA
TCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTCTCAGGCCCCTGGTGCAGGCAGAGTTATCTGTGCTCGTGGATGTTC
TCCACAGACCCGAGCTGCTTTTCCCAGAGAACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTTGCAAGTTAATAAAGCATA
CAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGGTCCTACAGACCCTGAGGGAAATGATGACCAAAGATAGAGGCTATG
GAGAAAAGCTAATTTCCATTGATGAATTGGATAATGCTGAGCTTCCTCCAGCTCCGGATTCTGAGAACGCCACTGAGGAGCTTGAACCAA
GTCCACCCCTGCGGCAGCTGGAAGACCATAAAAGGGGTGAGGCGCTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAACGTCAGACCTT
CGGGACGAAGAGAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGAGGAGGGGGAGGTTCCG
GATCCAGCTCTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTAGTTATCGACC
TCATCATGAACGCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGCAACACCACCATCCAGC
ACTCCTTTTTCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCCCAGCAAGAAA
TCAAAGCAACAGTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCCCCATCACGGAAAAAAG
GTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGG
CCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCT
CCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAA
ACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAG
AATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAA
TTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCA
GCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCA
TGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACC
CAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCC
AAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTAC
TTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATT
CAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTT
GGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATA
GCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGC
TTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGA
CGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAG
TGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGA
TTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGT
TTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCA
CAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTC
TCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTA
AAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTT
CAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAA
AGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGA
AAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTG
AAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAA
GAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACC

>40677_40677_7_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000302640_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2193AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRF
LDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSE
IPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
VTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQF
ILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMH
DYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGNN
KPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQ
NQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGED
VLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCY
VDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYH
CNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSAL
EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISIDELDN
AELPPAPDSENATEELEPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSL
AEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDL
GNKKKDDEVDRDAPSRKKGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVM
DFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKK
NRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQ

--------------------------------------------------------------
>40677_40677_8_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000354582_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8518nt_BP=6030nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGG
ACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACA
TCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTAT
GTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGA
AGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGG
GCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCG
TCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGA
ATATTCTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAGACTGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACC
AGCGGCACGCTCCTTTCAGACACATCTGCCGGCTCTGCTACAGGGTGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATA
TAGCCAAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATGTGTTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGA
AACTCCTGGAAAAACACATTACCGCGGCAGAGATTGACACATTTGTCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACC
TCTCCGACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCCAGGAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACA
TCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTTGAATTTGAAGGTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACG
AGGAAGAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTCGCAGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGC
AGAAGGAGGACCGAGACGTTCTCAGCTACTACAGATATCAGCTGAACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCA
ACGAAATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCATGTCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCC
GCCTCATGCTTCACATGCATGTGGACCGAGATCCCCAGGAACAAGTCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGG
AGATCGCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATGAAATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGT
ATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTCTCTGATAAAGAGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATC
TCATATACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAACTAAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAA
TCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAGAATAAAGGTAACAATGATGTGGAGAAGCTGAAGAGCAGTAACGTGATGAGATCTA
TTCATGGCGTGGGAGAGCTGATGACCCAGGTGGTGCTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCA
ATGTGAAGCAGGCAGAGCCTGAGAAGGAGGACATCATGGTCATGGACACCAAGCTGAAGATCATTGAGATACTCCAGTTTATTTTGAATG
TGAGGTTGGATTATAGGATCTCCTGCCTCCTGTGTATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCG
GAAACAGCAGCCAAGAAGGGCCAAGTAATGTACCAGGTGCTCTTGACTTTGAACACATTGAAGAACAAGCAGAAGGCATCTTTGGAGGAA
GTGAGGAGAACACCCCACTGGACTTGGATGACCACGGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCAC
CCCTGGTGTCAGGGGCCCTGCAGCTCCTCTTCCGGCACTTCAGCCAGAGGCAGGAGGTGCTCCAGGCCTTCAAACAGGTTCAACTGCTGG
TTACCAGCCAAGATGTGGACAACTACAAACAGATCAAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGT
ACAAAGGGCAGGGCCCCGATGAGACTATGGATGGTGCATCTGGAGAAAATGAACATAAGAAAACGGAGGAGGGAAATAACAAGCCACAAA
AGCATGAAAGCACCAGCAGCTACAACTACAGAGTGGTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAG
TGAGAAAGAGCAGGAAGCAGCAACAGCGTCTGCTCCGGAACATGGGCGCGCACGCCGTGGTGCTGGAGCTGCTGCAGATTCCCTATGAGA
AGGCCGAAGATACCAAGATGCAAGAGATAATGAGGTTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTT
TGCTACATAAACACATAAACCTGTTTCTCAACCCAGGGATCCTGGAGGCAGTAACCATGCAGCACATCTTCATGAACAATTTCCAGCTTT
GCAGTGAGATCAACGAGAGAGTTGTTCAGCACTTCGTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGA
CAATTGTCAAGGCAGAAGGGAAATTTATTAAAAAATGCCAAGACATGGTTATGGCCGAGCTGGTCAATTCGGGAGAGGATGTCCTCGTGT
TCTACAACGACAGAGCCTCTTTCCAGACTCTGATCCAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACC
ACATCCACTTGGTCGAGCTCCTGGCTGTGTGCACGGAGGGTAAGAATGTCTACACAGAGATCAAGTGCAACTCCCTGCTCCCGCTGGATG
ACATCGTTCGCGTGGTGACCCACGAGGACTGCATCCCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAG
AGGTGGAAATGAAGGAGATTTATACCAGCAATCACATGTGGAAATTGTTTGAGAATTTCCTTGTAGACATCTGCAGGGCCTGTAACAACA
CTAGTGACAGGAAACATGCAGACTCGATTTTGGAGAAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCT
TCTCAGACCAGAGTACGACTTTGCAGACTCGCCAGCCTGTCTTTGTGCAACTGCTGCAAGGCGTGTTCAGGGTTTACCACTGCAACTGGT
TAATGCCAAGCCAAAAAGCCTCCGTGGAGAGCTGTATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACC
TGGACAGCCAAGTCAACAACCTCTTTCTCAAGTCCCACAGCATTGTGCAGAAAACAGCCATGAACTGGCGGCTCTCAGCCCGCAATGCCG
CACGCAGGGACTCTGTTCTGGCAGCTTCCAGAGACTACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTC
TCAGGCCCCTGGTGCAGGCAGAGTTATCTGTGCTCGTGGATGTTCTCCACAGACCCGAGCTGCTTTTCCCAGAGAACACAGACGCCAGAA
GGAAATGTGAAAGTGGCGGTTTCATTTGCAAGTTAATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGG
TCCTACAGACCCTGAGGGAAATGATGACCAAAGATAGAGGCTATGGAGAAAAGCTAATTTCCATTGATGAATTGGATAATGCTGAGCTTC
CTCCAGCTCCGGATTCTGAGAACGCCACTGAGAAGGGTGAGGCGCTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAACGTCAGACCTT
CGGGACGAAGAGAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGAGGAGGGGGAGGTTCCG
GATCCAGCTCTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTAGTTATCGACC
TCATCATGAACGCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGCAACACCACCATCCAGC
ACTCCTTTTTCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCCCAGCAAGAAA
TCAAAGCAACAGTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCCCCATCACGGAAAAAAG
GTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGG
CCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCT
CCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAA
ACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAG
AATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAA
TTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCA
GCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCA
TGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACC
CAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCC
AAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTAC
TTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATT
CAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTT
GGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATA
GCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGC
TTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGA
CGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAG
TGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGA
TTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGT
TTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCA
CAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTC
TCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTA
AAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTT
CAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAA
AGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGA
AAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTG
AAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAA
GAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACC

>40677_40677_8_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000354582_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2193AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA
PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI
DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSN
KEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP
QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDL
LRLTKILLAILDCVHVTTIFPISKMAKGEENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDI
MVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDH
GGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDG
ASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMR
LAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKK
CQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCI
PEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQ
PVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRD
YRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKD
RGYGEKLISIDELDNAELPPAPDSENATEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSL
AEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDL
GNKKKDDEVDRDAPSRKKGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVM
DFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKK
NRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQ

--------------------------------------------------------------
>40677_40677_9_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000357086_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8417nt_BP=5929nt
AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG
GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC
ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA
GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA
ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT
GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC
CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC
GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG
CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT
GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG
AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC
AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT
GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT
GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT
TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGGAC
CCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATC
TCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGT
ACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAG
GAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGC
TCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTC
ACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAAT
ATTCTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAGACTGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACCAG
CGGCACGCTCCTTTCAGACACATCTGCCGGCTCTGCTACAGGGTGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATATA
GCCAAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATGTGTTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGAAA
CTCCTGGAAAAACACATTACCGCGGCAGAGATTGACACATTTGTCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACCTC
TCCGACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCCAGGAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACATC
CTGATTGAGACCAAGTTGGTTCTTTCTCGTTTTGAATTTGAAGGTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACGAG
GAAGAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTCGCAGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGCAG
AAGGAGGACCGAGACGTTCTCAGCTACTACAGATATCAGCTGAACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCAAC
GAAATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCATGTCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCCGC
CTCATGCTTCACATGCATGTGGACCGAGATCCCCAGGAACAAGTCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGGAG
ATCGCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATGAAATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGTAT
TTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTCTCTGATAAAGAGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATCTC
ATATACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAACTAAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAATC
TTCCCCATTAGCAAGATGGCGAAAGGAGAAGAGAATAAAGGCAGTAACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCCAG
GTGGTGCTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCAATGTGAAGCAGGCAGAGCCTGAGAAGGAG
GACATCATGGTCATGGACACCAAGCTGAAGATCATTGAGATACTCCAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCCTC
CTGTGTATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCGGAAACAGCAGCCAAGAAGGGCCAAGTAAT
GTACCAGGTGCTCTTGACTTTGAACACATTGAAGAACAAGCAGAAGGCATCTTTGGAGGAAGTGAGGAGAACACCCCACTGGACTTGGAT
GACCACGGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCACCCCTGGTGTCAGGGGCCCTGCAGCTCCTC
TTCCGGCACTTCAGCCAGAGGCAGGAGGTGCTCCAGGCCTTCAAACAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACAAA
CAGATCAAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGTACAAAGGGCAGGGCCCCGATGAGACTATG
GATGGTGCATCTGGAGAAAATGAACATAAGAAAACGGAGGAGGGAAATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACTAC
AGAGTGGTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAGTGAGAAAGAGCAGGAAGCAGCAACAGCGT
CTGCTCCGGAACATGGGCGCGCACGCCGTGGTGCTGGAGCTGCTGCAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGATA
ATGAGGTTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTTTGCTACATAAACACATAAACCTGTTTCTC
AACCCAGGGATCCTGGAGGCAGTAACCATGCAGCACATCTTCATGAACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTCAG
CACTTCGTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGACAATTGTCAAGGCAGAAGGGAAATTTATT
AAAAAATGCCAAGACATGGTTATGGCCGAGCTGGTCAATTCGGGAGAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGACT
CTGATCCAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACCACATCCACTTGGTCGAGCTCCTGGCTGTG
TGCACGGAGGGTAAGAATGTCTACACAGAGATCAAGTGCAACTCCCTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGGAC
TGCATCCCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAGAGGTGGAAATGAAGGAGATTTATACCAGC
AATCACATGTGGAAATTGTTTGAGAATTTCCTTGTAGACATCTGCAGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGATT
TTGGAGAAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCTTCTCAGACCAGAGTACGACTTTGCAGACT
CGCCAGCCTGTCTTTGTGCAACTGCTGCAAGGCGTGTTCAGGGTTTACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGGAG
AGCTGTATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACCTGGACAGCCAAGTCAACAACCTCTTTCTC
AAGTCCCACAGCATTGTGCAGAAAACAGCCATGAACTGGCGGCTCTCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTTCC
AGAGACTACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTCTCAGGCCCCTGGTGCAGGCAGAGTTATCT
GTGCTCGTGGATGTTCTCCACAGACCCGAGCTGCTTTTCCCAGAGAACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTTGC
AAGTTAATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGGTCCTACAGACCCTGAGGGAAATGATGACC
AAAGATAGAGGCTATGGAGAAAAGGGTGAGGCGCTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAACGTCAGACCTTCGGGACGAAGA
GAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGAGGAGGGGGAGGTTCCGGATCCAGCTCT
ATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTAGTTATCGACCTCATCATGAAC
GCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGCAACACCACCATCCAGCACTCCTTTTTC
TGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCCCAGCAAGAAATCAAAGCAACA
GTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCCCCATCACGGAAAAAAGGTGAGCTGTCA
GGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACGAG
AACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCA
TCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGCCA
GTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGAAG
GGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAGAG
TCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTC
CTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGAAG
TGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGATC
TCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGAAG
CCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAG
CAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTG
TGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAA
GTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTCGA
TACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAA
GGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCACC
AGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGGGA
GGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTA
AGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTA
ACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGT
AAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTA
ACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATTCC
GTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACT
ATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTATAA
ATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAATG
TATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAA
TTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGATGG
TCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCTCA

>40677_40677_9_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000357086_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2160AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA
PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI
DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSN
KEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP
QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDL
LRLTKILLAILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKI
IEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVL
LHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK
TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNF
CAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL
VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYIN
FLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQG
VFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQ
DIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEA
LRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESI
LLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKGELSGRNVETGQEMF
CSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSG
EQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFC
LPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD

--------------------------------------------------------------
>40677_40677_10_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000423119_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8419nt_BP=5931nt
GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG
AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG
ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA
GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA
AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG
ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA
ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC
ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC
TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG
CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC
TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT
GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC
ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT
CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC
GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCAGTGG
ACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACA
TCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTAT
GTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGA
AGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGG
GCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCG
TCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGA
ATATTCTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAGACTGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACC
AGCGGCACGCTCCTTTCAGACACATCTGCCGGCTCTGCTACAGGGTGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATA
TAGCCAAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATGTGTTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGA
AACTCCTGGAAAAACACATTACCGCGGCAGAGATTGACACATTTGTCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACC
TCTCCGACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCCAGGAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACA
TCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTTGAATTTGAAGGTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACG
AGGAAGAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTCGCAGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGC
AGAAGGAGGACCGAGACGTTCTCAGCTACTACAGATATCAGCTGAACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCA
ACGAAATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCATGTCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCC
GCCTCATGCTTCACATGCATGTGGACCGAGATCCCCAGGAACAAGTCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGG
AGATCGCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATGAAATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGT
ATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTCTCTGATAAAGAGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATC
TCATATACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAACTAAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAA
TCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAGAATAAAGGCAGTAACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCC
AGGTGGTGCTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCAATGTGAAGCAGGCAGAGCCTGAGAAGG
AGGACATCATGGTCATGGACACCAAGCTGAAGATCATTGAGATACTCCAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCC
TCCTGTGTATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCGGAAACAGCAGCCAAGAAGGGCCAAGTA
ATGTACCAGGTGCTCTTGACTTTGAACACATTGAAGAACAAGCAGAAGGCATCTTTGGAGGAAGGAAAGAGAACACCCCACTGGACTTGG
ATGACCACGGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCACCCCTGGTGTCAGGGGCCCTGCAGCTCC
TCTTCCGGCACTTCAGCCAGAGGCAGGAGGTGCTCCAGGCCTTCAAACAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACA
AACAGATCAAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGTACAAAGGGCAGGGCCCCGATGAGACTA
TGGATGGTGCATCTGGAGAAAATGAACATAAGAAAACGGAGGAGGGAAATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACT
ACAGAGTGGTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAGTGAGAAAGAGCAGGAAGCAGCAACAGC
GTCTGCTCCGGAACATGGGCGCGCACGCCGTGGTGCTGGAGCTGCTGCAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGA
TAATGAGGTTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTTTGCTACATAAACACATAAACCTGTTTC
TCAACCCAGGGATCCTGGAGGCAGTAACCATGCAGCACATCTTCATGAACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTC
AGCACTTCGTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGACAATTGTCAAGGCAGAAGGGAAATTTA
TTAAAAAATGCCAAGACATGGTTATGGCCGAGCTGGTCAATTCGGGAGAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGA
CTCTGATCCAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACCACATCCACTTGGTCGAGCTCCTGGCTG
TGTGCACGGAGGGTAAGAATGTCTACACAGAGATCAAGTGCAACTCCCTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGG
ACTGCATCCCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAGAGGTGGAAATGAAGGAGATTTATACCA
GCAATCACATGTGGAAATTGTTTGAGAATTTCCTTGTAGACATCTGCAGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGA
TTTTGGAGAAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCTTCTCAGACCAGAGTACGACTTTGCAGA
CTCGCCAGCCTGTCTTTGTGCAACTGCTGCAAGGCGTGTTCAGGGTTTACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGG
AGAGCTGTATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACCTGGACAGCCAAGTCAACAACCTCTTTC
TCAAGTCCCACAGCATTGTGCAGAAAACAGCCATGAACTGGCGGCTCTCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTT
CCAGAGACTACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTCTCAGGCCCCTGGTGCAGGCAGAGTTAT
CTGTGCTCGTGGATGTTCTCCACAGACCCGAGCTGCTTTTCCCAGAGAACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTT
GCAAGTTAATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGGTCCTACAGACCCTGAGGGAAATGATGA
CCAAAGATAGAGGCTATGGAGAAAAGGGTGAGGCGCTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAACGTCAGACCTTCGGGACGAA
GAGAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGAGGAGGGGGAGGTTCCGGATCCAGCT
CTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTAGTTATCGACCTCATCATGA
ACGCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGCAACACCACCATCCAGCACTCCTTTT
TCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCCCAGCAAGAAATCAAAGCAA
CAGTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCCCCATCACGGAAAAAAGGTGAGCTGT
CAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACG
AGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGC
CATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGC
CAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGA
AGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAG
AGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGT
TCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGA
AGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGA
TCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGA
AGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAA
AGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTG
TGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGG
AAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTC
GATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAG
AAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCA
CCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGG
GAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTAC
TAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCC
TAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGA
GTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCC
TAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATT
CCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCA
CTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTAT
AAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAA
TGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAA
AATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGAT
GGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCT

>40677_40677_10_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000423119_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2160AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLR
NAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA
PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI
DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSN
KEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP
QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDL
LRLTKILLAILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKI
IEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVL
LHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK
TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNF
CAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL
VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYIN
FLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQG
VFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQ
DIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEA
LRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESI
LLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKGELSGRNVETGQEMF
CSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSG
EQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFC
LPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD

--------------------------------------------------------------
>40677_40677_11_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000443694_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8168nt_BP=5680nt
ATGTCTGACAAAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTG
GGCCTGGTTGATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTA
TGTCCCATGAACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAAC
AAACTGCACCACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTG
ATCCAGCTCCTGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACA
TTGGACGAGGCTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGAC
AAGGTGGTTCTGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAAT
TCCGTCAACTGCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTG
AGGCTGTTTCATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAG
TCGGCCACATCTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAAC
AGCCTTTTCCGTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGG
AATGCCCAAGAAAAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTG
CGTGGAGGTGACAGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCT
ATTGACAAGGAAGAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTT
TCTCCTGCTGAAGTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATC
ACCCAGAATGAAAGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTC
GAAGTTGTCTTCTCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGATCTTCAAGTTGTTACAAGCC
CCATTCACAGACTGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACCAGCGGCACGCTCCTTTCAGACACATCTGCCGGCTC
TGCTACAGGGTGCTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATATAGCCAAGCAGTTTGGCTTCATGCAGAAGCAGATT
GGCTATGATGTGTTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGAAACTCCTGGAAAAACACATTACCGCGGCAGAGATT
GACACATTTGTCAGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACCTCTCCGACCTCTGTGTCTCCATGAACAAATCAATT
CCAGTGACCCAGGAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACATCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTT
GAATTTGAAGGTGTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACGAGGAAGAGGTGTGGCTGTTTTGGAGGGACAGCAAC
AAAGAGATTCGCAGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGCAGAAGGAGGACCGAGACGTTCTCAGCTACTACAGA
TATCAGCTGAACCTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCAACGAAATCTCAGGCCAGCTGGATGTCGATCTCATT
CTCCGCTGCATGTCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCCGCCTCATGCTTCACATGCATGTGGACCGAGATCCC
CAGGAACAAGTCACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGGAGATCGCCATTGACGACTATGATAGTAGTGGAGCT
TCCAAAGATGAAATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGTATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTC
TCTGATAAAGAGAAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATCTCATATACTTTGGTTTCTACAACTTCTCTGACCTT
CTACGATTAACTAAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAATCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAG
AATAAAGGTAACAATGATGTGGAGAAGCTGAAGAGCAGTAACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCCAGGTGGTG
CTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCTGCTGCCCCTGAAGGCAATGTGAAGCAGGCAGAGCCTGAGAAGGAGGACATC
ATGGTCATGGACACCAAGCTGAAGATCATTGAGATACTCCAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCCTCCTGTGT
ATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACTTCAGAAACATCCTCCGGAAACAGCAGCCAAGAAGGGCCAAGTAATGTACCA
GGTGCTCTTGACTTTGAACACATTGAAGAACAAGCAGAAGGCATCTTTGGAGGAAGTGAGGAGAACACCCCACTGGACTTGGATGACCAC
GGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACGATGCATGACTACCCACCCCTGGTGTCAGGGGCCCTGCAGCTCCTCTTCCGG
CACTTCAGCCAGAGGCAGGAGGTGCTCCAGGCCTTCAAACAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACAAACAGATC
AAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAGTCAGAGCTTTGGGTGTACAAAGGGCAGGGCCCCGATGAGACTATGGATGGT
GCATCTGGAGAAAATGAACATAAGAAAACGGAGGAGGGAAATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACTACAGAGTG
GTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTTCAAGAGAGTGCCTCAGTGAGAAAGAGCAGGAAGCAGCAACAGCGTCTGCTC
CGGAACATGGGCGCGCACGCCGTGGTGCTGGAGCTGCTGCAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGATAATGAGG
TTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAACCAGCAGAATCAAGCTTTGCTACATAAACACATAAACCTGTTTCTCAACCCA
GGGATCCTGGAGGCAGTAACCATGCAGCACATCTTCATGAACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTCAGCACTTC
GTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTATATAAAGTTCTTACAGACAATTGTCAAGGCAGAAGGGAAATTTATTAAAAAA
TGCCAAGACATGGTTATGGCCGAGCTGGTCAATTCGGGAGAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGACTCTGATC
CAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAACAGCCCTCTCATGTACCACATCCACTTGGTCGAGCTCCTGGCTGTGTGCACG
GAGGGTAAGAATGTCTACACAGAGATCAAGTGCAACTCCCTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGGACTGCATC
CCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCACTGCTATGTGGATACAGAGGTGGAAATGAAGGAGATTTATACCAGCAATCAC
ATGTGGAAATTGTTTGAGAATTTCCTTGTAGACATCTGCAGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGATTTTGGAG
AAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACTTTCTTCAGCTCTCCCTTCTCAGACCAGAGTACGACTTTGCAGACTCGCCAG
CCTGTCTTTGTGCAACTGCTGCAAGGCGTGTTCAGGGTTTACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGGAGAGCTGT
ATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATTGCCATTCCCGTGGACCTGGACAGCCAAGTCAACAACCTCTTTCTCAAGTCC
CACAGCATTGTGCAGAAAACAGCCATGAACTGGCGGCTCTCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTTCCAGAGAC
TACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCCGCGCTGGAGGACCGTCTCAGGCCCCTGGTGCAGGCAGAGTTATCTGTGCTC
GTGGATGTTCTCCACAGACCCGAGCTGCTTTTCCCAGAGAACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTTGCAAGTTA
ATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAGAAGCTCTGCATTAAGGTCCTACAGACCCTGAGGGAAATGATGACCAAAGAT
AGAGGCTATGGAGAAAAGCTAATTTCCATTGATGAATTGGATAATGCTGAGCTTCCTCCAGCTCCGGATTCTGAGAACGCCACTGAGGAG
CTTGAACCAAGTCCACCCCTGCGGCAGCTGGAAGACCATAAAAGGGGTGAGGCGCTCAGGCAAGTTCTGGTCAACCGTTACTATGGAAAC
GTCAGACCTTCGGGACGAAGAGAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGACCCGGCAAGCCCGGGGGAGGAGGG
GGAGGTTCCGGATCCAGCTCTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTTGACAAGGAGGGGGCTTCCAATCTA
GTTATCGACCTCATCATGAACGCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATTGCCCTTCTGGAAGGAGGCAACACC
ACCATCCAGCACTCCTTTTTCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTGTTTTATGACCGGATGAAGGTGGCC
CAGCAAGAAATCAAAGCAACAGTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGATGAGGTAGACAGGGATGCCCCATCA
CGGAAAAAAGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTT
CAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCGGAGCTGCTGCAG
GGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGT
CCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGACACAGACAGTGGC
TATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGG
ATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCATTTCACTAGCAGT
GACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCC
TACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCAGCCCTCTCTAGC
TTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCT
GTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCT
TCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGG
AGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAA
AGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCAC
CCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTG
GGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTGCCT
TTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAGCAGGCACTGGCAT
AGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGAGAATGTAGTTCCCTACTCAGGCT
TTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTC
TGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACC
CCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAA
GCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTC
CTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGC
AGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTGCCT
TTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATAATTACTTGATTCA
CACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGAGAGGTACAGTGTTTATATTTTGG
AGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTAAAATACTTAATAAAATAATTCTTT
TCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGACTCCCATGTCCTTCTTTCTTGGCT

>40677_40677_11_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000443694_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2178AA_BP=0
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLN
KLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQ
SATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTL
RGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTI
TQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRL
CYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSI
PVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYR
YQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGA
SKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEE
NKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLC
IFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFR
HFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRV
VKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNP
GILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLI
QMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNH
MWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESC
IRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVL
VDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENATEE
LEPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNL
VIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPS
RKKGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEG
PGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSS
DLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSS

--------------------------------------------------------------
>40677_40677_12_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000456211_BHLHE40_chr3_5024521_ENST00000256495_length(transcript)=8372nt_BP=5884nt
AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG
GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC
ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA
GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA
ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT
GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC
CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC
GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG
CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT
GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG
AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC
AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT
GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT
GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT
TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTGGACCCTGATCAGGACGCCTCTCGAAGTAGGTTGCGGAATGCCCAAGAA
AAGATGGTATACTCCCTGGTCTCTGTGCCTGAAGGCAATGACATCTCCTCCATTTTCGAGCTAGATCCCACCACTCTGCGTGGAGGTGAC
AGCCTTGTCCCAAGGAACTCTTATGTTCGGCTCAGACACCTATGTACTAATACCTGGGTTCACAGCACAAATATTCCTATTGACAAGGAA
GAAGAAAAGCCCGTGATGCTGAAAATTGGCACCTCTCCTGTGAAGGAGGATAAGGAAGCATTTGCCATAGTTCCGGTTTCTCCTGCTGAA
GTTCGGGACCTGGACTTTGCCAATGATGCCAGCAAGGTGCTGGGCTCCATTGCTGGGAAGCTAGAGAAGGGCACCATCACCCAGAATGAA
AGGAGGTCTGTAACCAAGCTGCTAGAAGATTTGGTTTACTTCGTCACTGGTGGAACTAATTCTGGTCAAGATGTTCTCGAAGTTGTCTTC
TCCAAGCCCAACAGAGAACGGCAGAAACTGATGAGAGAACAGAATATTCTCAAGCAGATCTTCAAGTTGTTACAAGCCCCATTCACAGAC
TGCGGTGATGGCCCAATGCTTCGGCTGGAAGAGCTCGGGGACCAGCGGCACGCTCCTTTCAGACACATCTGCCGGCTCTGCTACAGGGTG
CTGAGACACTCGCAGCAAGACTACAGGAAGAACCAGGAGTATATAGCCAAGCAGTTTGGCTTCATGCAGAAGCAGATTGGCTATGATGTG
TTGGCTGAAGACACTATCACTGCCCTGCTCCACAATAATCGGAAACTCCTGGAAAAACACATTACCGCGGCAGAGATTGACACATTTGTC
AGCCTGGTGCGAAAGAACAGGGAGCCCAGATTCTTAGATTACCTCTCCGACCTCTGTGTCTCCATGAACAAATCAATTCCAGTGACCCAG
GAACTGATATGTAAAGCTGTGCTGAACCCCACCAACGCTGACATCCTGATTGAGACCAAGTTGGTTCTTTCTCGTTTTGAATTTGAAGGT
GTCTCTTCCACTGGAGAGAATGCTCTGGAGGCAGGAGAAGACGAGGAAGAGGTGTGGCTGTTTTGGAGGGACAGCAACAAAGAGATTCGC
AGCAAGAGTGTGAGGGAATTGGCTCAGGATGCTAAAGAAGGGCAGAAGGAGGACCGAGACGTTCTCAGCTACTACAGATATCAGCTGAAC
CTCTTTGCGAGGATGTGTCTGGACCGCCAATACCTGGCCATCAACGAAATCTCAGGCCAGCTGGATGTCGATCTCATTCTCCGCTGCATG
TCTGACGAGAACCTGCCCTATGACCTCAGGGCGTCCTTCTGCCGCCTCATGCTTCACATGCATGTGGACCGAGATCCCCAGGAACAAGTC
ACCCCCGTGAAATATGCCCGCCTCTGGTCGGAGATTCCCTCGGAGATCGCCATTGACGACTATGATAGTAGTGGAGCTTCCAAAGATGAA
ATTAAGGAGAGATTTGCTCAGACCATGGAGTTTGTGGAGGAGTATTTAAGAGATGTGGTTTGTCAGAGGTTCCCTTTCTCTGATAAAGAG
AAGAATAAGCTTACGTTTGAGGTTGTAAATTTAGCTAGGAATCTCATATACTTTGGTTTCTACAACTTCTCTGACCTTCTACGATTAACT
AAGATCCTTCTGGCCATATTGGACTGTGTACATGTGACAACAATCTTCCCCATTAGCAAGATGGCGAAAGGAGAAGAGAATAAAGGCAGT
AACGTGATGAGATCTATTCATGGCGTGGGAGAGCTGATGACCCAGGTGGTGCTCCGGGGAGGAGGCTTTTTGCCCATGACTCCCATGGCT
GCTGCCCCTGAAGGCAATGTGAAGCAGGCAGAGCCTGAGAAGGAGGACATCATGGTCATGGACACCAAGCTGAAGATCATTGAGATACTC
CAGTTTATTTTGAATGTGAGGTTGGATTATAGGATCTCCTGCCTCCTGTGTATATTTAAGCGAGAGTTTGATGAAAGCAATTCCCAGACT
TCAGAAACATCCTCCGGAAACAGCAGCCAAGAAGGGCCAAGTAATGTACCAGGTGCTCTTGACTTTGAACACATTGAAGAACAAGCAGAA
GGCATCTTTGGAGGAAGTGAGGAGAACACCCCACTGGACTTGGATGACCACGGCGGCAGAACCTTTCTCCGTGTCCTGCTCCACTTGACG
ATGCATGACTACCCACCCCTGGTGTCAGGGGCCCTGCAGCTCCTCTTCCGGCACTTCAGCCAGAGGCAGGAGGTGCTCCAGGCCTTCAAA
CAGGTTCAACTGCTGGTTACCAGCCAAGATGTGGACAACTACAAACAGATCAAACAAGACTTGGATCAACTGAGGTCCATCGTGGAAAAG
TCAGAGCTTTGGGTGTACAAAGGGCAGGGCCCCGATGAGACTATGGATGGTGCATCTGGAGAAAATGAACATAAGAAAACGGAGGAGGGA
AATAACAAGCCACAAAAGCATGAAAGCACCAGCAGCTACAACTACAGAGTGGTCAAAGAGATTTTGATTCGGCTTAGCAAACTCTGTGTT
CAAGAGAGTGCCTCAGTGAGAAAGAGCAGGAAGCAGCAACAGCGTCTGCTCCGGAACATGGGCGCGCACGCCGTGGTGCTGGAGCTGCTG
CAGATTCCCTATGAGAAGGCCGAAGATACCAAGATGCAAGAGATAATGAGGTTGGCTCATGAATTTTTGCAGAATTTCTGCGCAGGCAAC
CAGCAGAATCAAGCTTTGCTACATAAACACATAAACCTGTTTCTCAACCCAGGGATCCTGGAGGCAGTAACCATGCAGCACATCTTCATG
AACAATTTCCAGCTTTGCAGTGAGATCAACGAGAGAGTTGTTCAGCACTTCGTTCACTGCATAGAGACTCACGGTCGGAATGTCCAGTAT
ATAAAGTTCTTACAGACAATTGTCAAGGCAGAAGGGAAATTTATTAAAAAATGCCAAGACATGGTTATGGCCGAGCTGGTCAATTCGGGA
GAGGATGTCCTCGTGTTCTACAACGACAGAGCCTCTTTCCAGACTCTGATCCAGATGATGCGGTCAGAACGGGATCGGATGGATGAGAAC
AGCCCTCTCATGTACCACATCCACTTGGTCGAGCTCCTGGCTGTGTGCACGGAGGGTAAGAATGTCTACACAGAGATCAAGTGCAACTCC
CTGCTCCCGCTGGATGACATCGTTCGCGTGGTGACCCACGAGGACTGCATCCCTGAGGTTAAAATTGCATACATTAACTTCCTGAATCAC
TGCTATGTGGATACAGAGGTGGAAATGAAGGAGATTTATACCAGCAATCACATGTGGAAATTGTTTGAGAATTTCCTTGTAGACATCTGC
AGGGCCTGTAACAACACTAGTGACAGGAAACATGCAGACTCGATTTTGGAGAAGTATGTCACCGAAATCGTCATGAGTATTGTTACTACT
TTCTTCAGCTCTCCCTTCTCAGACCAGAGTACGACTTTGCAGACTCGCCAGCCTGTCTTTGTGCAACTGCTGCAAGGCGTGTTCAGGGTT
TACCACTGCAACTGGTTAATGCCAAGCCAAAAAGCCTCCGTGGAGAGCTGTATTCGGGTGCTGTCTGATGTAGCCAAGAGCCGGGCCATT
GCCATTCCCGTGGACCTGGACAGCCAAGTCAACAACCTCTTTCTCAAGTCCCACAGCATTGTGCAGAAAACAGCCATGAACTGGCGGCTC
TCAGCCCGCAATGCCGCACGCAGGGACTCTGTTCTGGCAGCTTCCAGAGACTACCGGAATATCATTGAGAGATTGCAGGACATCGTCTCC
GCGCTGGAGGACCGTCTCAGGCCCCTGGTGCAGGCAGAGTTATCTGTGCTCGTGGATGTTCTCCACAGACCCGAGCTGCTTTTCCCAGAG
AACACAGACGCCAGAAGGAAATGTGAAAGTGGCGGTTTCATTTGCAAGTTAATAAAGCATACAAAACAGCTGCTAGAAGAAAATGAAGAG
AAGCTCTGCATTAAGGTCCTACAGACCCTGAGGGAAATGATGACCAAAGATAGAGGCTATGGAGAAAAGGGTGAGGCGCTCAGGCAAGTT
CTGGTCAACCGTTACTATGGAAACGTCAGACCTTCGGGACGAAGAGAGAGCCTTACCAGCTTTGGCAATGGCCCACTGTCAGCAGGAGGA
CCCGGCAAGCCCGGGGGAGGAGGGGGAGGTTCCGGATCCAGCTCTATGAGCAGGGGTGAGATGAGTCTGGCCGAGGTTCAGTGTCACCTT
GACAAGGAGGGGGCTTCCAATCTAGTTATCGACCTCATCATGAACGCATCCAGTGACCGAGTGTTCCATGAAAGCATTCTCCTGGCCATT
GCCCTTCTGGAAGGAGGCAACACCACCATCCAGCACTCCTTTTTCTGTCGCTTGACAGAAGATAAGAAGTCAGAGAAATTCTTTAAGGTG
TTTTATGACCGGATGAAGGTGGCCCAGCAAGAAATCAAAGCAACAGTGACAGTGAACACCAGTGACTTGGGAAATAAAAAGAAAGACGAT
GAGGTAGACAGGGATGCCCCATCACGGAAAAAAGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAGATGTTCTGCTCAGGTTTC
CAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCACGAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCAC
CGGGTGGTCTCGGAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGACTTCAAGGAAAAACCCAGC
TCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTGCCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGC
AGCGACACGGACACAGACAGTGGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGCTTCAAAAGTGACCACGGA
CGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAAGAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGAT
GATGAAGGCCATTTCACTAGCAGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCTTTCTGCCTGCCCTTCTAC
CTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAGAAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAAC
GCCTCTGCCGCAGCCCTCTCTAGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGACTCCCTTCTCCCTTGCCA
GCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTGAAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAAACTCTCTAG
GGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTGCAAGATTGTTGCATTGTGT
ATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGCGTGTGCGTGCACATGTGTGC
CTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAAGTCACGAAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTA
GCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCTTCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTG
AGTCACTCTTCAGTTTGGGAGCTGGGTCTGTGGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGC
TGTTAGGACCCCACCCTTTTGCCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACA
TGGGGAGGTAGCAGGCACTGGCATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAG
AGAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCTGCCCCGGAG
GGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAACCAAACCAAGGTCTGAGAA
ATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTTCAAACAGAACTAGACTCAGTTTTCAATTC
CATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTAACCAAGCCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTC
TTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGATTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTT
CCCGATGTGTCCAGCCAGCTCCGCAGCAGCTTTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTT
TATTTTGGTATTAAGTCGTTGCCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGT
TTATTTGTATAATTACTTGATTCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGG
AGAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTAGTTGTTTTA
AAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAGATGGTCTCCTGAGTTTTTTAAAATAGCTCACTTGGTGTGATATGGCTGA
CTCCCATGTCCTTCTTTCTTGGCTGAAGCAAACCAGTTAATCTCAGTGTAATTTCATTCAGCTTTTCATGTGCTTTGTATTCAATCAGAA

>40677_40677_12_ITPR1-BHLHE40_ITPR1_chr3_4808394_ENST00000456211_BHLHE40_chr3_5024521_ENST00000256495_length(amino acids)=2145AA_BP=1
MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA
AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP
FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRF
LDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSE
IPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYR
ISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA
LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGNNKPQKHESTS
SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI
NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRA
SFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE
IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQK
ASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ
AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRP
SGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ
HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKGELSGRNVETGQEMFCSGFQTCAREVLQYL
AKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGG
ESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLP

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Top

Fusion Gene PPI Analysis for ITPR1-BHLHE40

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ITPR1	chr3:4704890	chr3:5023077	ENST00000302640	+	15	61	2472_2537	503.0	2744.0	ERP44
Hgene	ITPR1	chr3:4704890	chr3:5023077	ENST00000357086	+	16	59	2472_2537	518.0	2711.0	ERP44
Hgene	ITPR1	chr3:4704890	chr3:5023077	ENST00000443694	+	13	59	2472_2537	503.0	2744.0	ERP44
Hgene	ITPR1	chr3:4704890	chr3:5023077	ENST00000456211	+	15	58	2472_2537	503.0	2696.0	ERP44
Hgene	ITPR1	chr3:4808394	chr3:5024521	ENST00000302640	+	44	61	2472_2537	1893.3333333333333	2744.0	ERP44
Hgene	ITPR1	chr3:4808394	chr3:5024521	ENST00000357086	+	42	59	2472_2537	1860.3333333333333	2711.0	ERP44
Hgene	ITPR1	chr3:4808394	chr3:5024521	ENST00000443694	+	42	59	2472_2537	1893.3333333333333	2744.0	ERP44
Hgene	ITPR1	chr3:4808394	chr3:5024521	ENST00000456211	+	41	58	2472_2537	1845.3333333333333	2696.0	ERP44

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ITPR1-BHLHE40

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ITPR1-BHLHE40

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source