FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ALKBH8-ALKBH8 (FusionGDB2 ID:4069)

Fusion Gene Summary for ALKBH8-ALKBH8

check button Fusion gene summary
Fusion gene informationFusion gene name: ALKBH8-ALKBH8
Fusion gene ID: 4069
HgeneTgene
Gene symbol

ALKBH8

ALKBH8

Gene ID

91801

91801

Gene namealkB homolog 8, tRNA methyltransferasealkB homolog 8, tRNA methyltransferase
SynonymsABH8|MRT71|TRM9|TRMT9|TRMT9AABH8|MRT71|TRM9|TRMT9|TRMT9A
Cytomap

11q22.3

11q22.3

Type of geneprotein-codingprotein-coding
Descriptionalkylated DNA repair protein alkB homolog 8AlkB homologue 8S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8alkB, alkylation repair homolog 8probable alpha-ketoglutarate-dependent dioxygenase ABH8tRNA (carboxymethyluridine(34)-5-O)-methylalkylated DNA repair protein alkB homolog 8AlkB homologue 8S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8alkB, alkylation repair homolog 8probable alpha-ketoglutarate-dependent dioxygenase ABH8tRNA (carboxymethyluridine(34)-5-O)-methyl
Modification date2020031420200314
UniProtAcc

Q96BT7

Q96BT7

Ensembl transtripts involved in fusion geneENST00000429370, ENST00000389568, 
ENST00000417449, ENST00000428149, 
ENST00000530933, 		ENST00000389568, 
ENST00000417449, ENST00000429370, 
ENST00000530933, ENST00000428149, 
Fusion gene scores* DoF score3 X 4 X 2=242 X 3 X 1=6
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/6*10)=2.32192809488736
Context

PubMed: ALKBH8 [Title/Abstract] AND ALKBH8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALKBH8(107373755)-ALKBH8(107375681), # samples:1
ALKBH8(107375681)-ALKBH8(107373755), # samples:1
Anticipated loss of major functional domain due to fusion event.ALKBH8-ALKBH8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ALKBH8-ALKBH8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALKBH8

GO:0002098

tRNA wobble uridine modification

21285950

HgeneALKBH8

GO:0006974

cellular response to DNA damage stimulus

20308323

HgeneALKBH8

GO:0030488

tRNA methylation

20308323

HgeneALKBH8

GO:0055114

oxidation-reduction process

21285950

TgeneALKBH8

GO:0002098

tRNA wobble uridine modification

21285950

TgeneALKBH8

GO:0006974

cellular response to DNA damage stimulus

20308323

TgeneALKBH8

GO:0030488

tRNA methylation

20308323

TgeneALKBH8

GO:0055114

oxidation-reduction process

21285950


check buttonFusion gene breakpoints across ALKBH8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALKBH8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK095523ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
ChiTaRS5.0N/ADB315008ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+


Top

Fusion Gene ORF analysis for ALKBH8-ALKBH8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000429370ENST00000389568ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
5CDS-intronENST00000429370ENST00000417449ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
5CDS-intronENST00000429370ENST00000429370ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
5CDS-intronENST00000429370ENST00000530933ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
Frame-shiftENST00000429370ENST00000428149ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-3CDSENST00000389568ENST00000428149ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-3CDSENST00000417449ENST00000428149ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-3CDSENST00000428149ENST00000428149ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-3CDSENST00000530933ENST00000428149ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-3UTRENST00000389568ENST00000428149ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-3UTRENST00000417449ENST00000428149ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-3UTRENST00000428149ENST00000428149ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-3UTRENST00000429370ENST00000428149ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-3UTRENST00000530933ENST00000428149ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000389568ENST00000389568ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000389568ENST00000389568ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000389568ENST00000417449ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000389568ENST00000417449ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000389568ENST00000429370ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000389568ENST00000429370ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000389568ENST00000530933ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000389568ENST00000530933ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000417449ENST00000389568ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000417449ENST00000389568ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000417449ENST00000417449ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000417449ENST00000417449ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000417449ENST00000429370ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000417449ENST00000429370ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000417449ENST00000530933ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000417449ENST00000530933ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000428149ENST00000389568ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000428149ENST00000389568ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000428149ENST00000417449ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000428149ENST00000417449ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000428149ENST00000429370ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000428149ENST00000429370ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000428149ENST00000530933ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000428149ENST00000530933ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000429370ENST00000389568ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000429370ENST00000417449ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000429370ENST00000429370ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000429370ENST00000530933ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000530933ENST00000389568ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000530933ENST00000389568ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000530933ENST00000417449ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000530933ENST00000417449ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000530933ENST00000429370ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000530933ENST00000429370ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+
intron-intronENST00000530933ENST00000530933ALKBH8chr11

107373755

-ALKBH8chr11

107375681

-
intron-intronENST00000530933ENST00000530933ALKBH8chr11

107375681

+ALKBH8chr11

107373755

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ALKBH8-ALKBH8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ALKBH8-ALKBH8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:107373755/:107375681)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALKBH8

Q96BT7

ALKBH8

Q96BT7

FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ALKBH8-ALKBH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ALKBH8-ALKBH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ALKBH8-ALKBH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ALKBH8-ALKBH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource