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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITPR2-ANO2 (FusionGDB2 ID:40690)

Fusion Gene Summary for ITPR2-ANO2

check button Fusion gene summary
Fusion gene informationFusion gene name: ITPR2-ANO2
Fusion gene ID: 40690
HgeneTgene
Gene symbol

ITPR2

ANO2

Gene ID

3709

57101

Gene nameinositol 1,4,5-trisphosphate receptor type 2anoctamin 2
SynonymsANHD|CFAP48|INSP3R2|IP3R2C12orf3|TMEM16B
Cytomap

12p11.23

12p13.31

Type of geneprotein-codingprotein-coding
Descriptioninositol 1,4,5-trisphosphate receptor type 2IP3 receptorIP3R 2cilia and flagella associated protein 48type 2 InsP3 receptoranoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)
Modification date2020031320200329
UniProtAcc.

Q9NQ90

Ensembl transtripts involved in fusion geneENST00000381340, ENST00000242737, 
ENST00000545902, 		ENST00000538154, 
ENST00000546188, ENST00000327087, 
ENST00000356134, 
Fusion gene scores* DoF score21 X 18 X 10=378012 X 11 X 8=1056
# samples 2315
** MAII scorelog2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITPR2 [Title/Abstract] AND ANO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITPR2(26580846)-ANO2(5941769), # samples:3
Anticipated loss of major functional domain due to fusion event.ITPR2-ANO2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ITPR2-ANO2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITPR2

GO:0001666

response to hypoxia

19120137


check buttonFusion gene breakpoints across ITPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A4SD-01AITPR2chr12

26580846

-ANO2chr12

5941769

-


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Fusion Gene ORF analysis for ITPR2-ANO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381340ENST00000538154ITPR2chr12

26580846

-ANO2chr12

5941769

-
Frame-shiftENST00000381340ENST00000546188ITPR2chr12

26580846

-ANO2chr12

5941769

-
In-frameENST00000381340ENST00000327087ITPR2chr12

26580846

-ANO2chr12

5941769

-
In-frameENST00000381340ENST00000356134ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000242737ENST00000327087ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000242737ENST00000356134ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000242737ENST00000546188ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000545902ENST00000327087ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000545902ENST00000356134ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-3CDSENST00000545902ENST00000546188ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-intronENST00000242737ENST00000538154ITPR2chr12

26580846

-ANO2chr12

5941769

-
intron-intronENST00000545902ENST00000538154ITPR2chr12

26580846

-ANO2chr12

5941769

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381340ITPR2chr1226580846-ENST00000327087ANO2chr125941769-10386736241797373106
ENST00000381340ITPR2chr1226580846-ENST00000356134ANO2chr125941769-10383736241797373106

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381340ENST00000327087ITPR2chr1226580846-ANO2chr125941769-0.000593360.9994067
ENST00000381340ENST00000356134ITPR2chr1226580846-ANO2chr125941769-0.0005916110.99940836

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Fusion Genomic Features for ITPR2-ANO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITPR2-ANO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:26580846/chr12:5941769)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANO2

Q9NQ90

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523, ECO:0000269|PubMed:21984732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957112_16623152702.0DomainMIR 1
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957173_22323152702.0DomainMIR 2
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957231_28723152702.0DomainMIR 3
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957294_37223152702.0DomainMIR 4
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957378_43423152702.0DomainMIR 5
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957265_26923152702.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957507_51023152702.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-4957567_56923152702.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49571_222723152702.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572249_226023152702.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572282_230723152702.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572228_224823152702.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572261_228123152702.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST000003270873261001_1003207999.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr12:26580846chr12:5941769ENST000003561344271001_10032081000.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326387_434207999.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326456_538207999.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326560_582207999.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326604_623207999.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326645_748207999.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326770_801207999.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326823_907207999.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326929_1003207999.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427387_4342081000.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427456_5382081000.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427560_5822081000.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427604_6232081000.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427645_7482081000.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427770_8012081000.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427823_9072081000.0Topological domainExtracellular
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427929_10032081000.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326366_386207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326435_455207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326539_559207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326583_603207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326624_644207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326749_769207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326802_822207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000327087326908_928207999.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427366_3862081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427435_4552081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427539_5592081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427583_6032081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427624_6442081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427749_7692081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427802_8222081000.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST00000356134427908_9282081000.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16112_1660182.0DomainMIR 1
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16173_2230182.0DomainMIR 2
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16231_2870182.0DomainMIR 3
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16294_3720182.0DomainMIR 4
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16378_4340182.0DomainMIR 5
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16265_2690182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16507_5100182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-16567_5690182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-161_22270182.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162249_22600182.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162282_23070182.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162329_23510182.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162373_23940182.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162416_25210182.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162543_27010182.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572329_235123152702.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572373_239423152702.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572416_252123152702.0Topological domainExtracellular
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572543_270123152702.0Topological domainCytoplasmic
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162228_22480182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162261_22810182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162308_23280182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162352_23720182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162395_24150182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000242737-162522_25420182.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572308_232823152702.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572352_237223152702.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572395_241523152702.0TransmembraneHelical
HgeneITPR2chr12:26580846chr12:5941769ENST00000381340-49572522_254223152702.0TransmembraneHelical
TgeneANO2chr12:26580846chr12:5941769ENST000003270873261_365207999.0Topological domainCytoplasmic
TgeneANO2chr12:26580846chr12:5941769ENST000003561344271_3652081000.0Topological domainCytoplasmic


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Fusion Gene Sequence for ITPR2-ANO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40690_40690_1_ITPR2-ANO2_ITPR2_chr12_26580846_ENST00000381340_ANO2_chr12_5941769_ENST00000327087_length(transcript)=10386nt_BP=7362nt
CTTCCAGCTCCCGCCGGGCGGCTGTGACGGCCGCAGCGGGTCGCAGAGCAGGGAGTGGACACGGAGTGGGGAGCGGAGAGGGAAGGAGGA
GGAGGAGGAGCAAAGGTGTTGGAGAGAAAACTTCAGAAAGGAACAGGAAACCTGCCGGGGAGGCGGCGGCGGCTGCGGCTTCTCTGGGCG
CCTGGGCTGCGCTCTTCGCGGGGTGTCCGCAGCTGCGGCTTGGCCCCGGTCTGGCTTCCCCGGCGCGCACGCACGGCTGAGCCGCGACGC
TCAGTGGCTCGGGCCGTGCCCTCCGCCGCGGCTCTTGGCCGCTGTAGTCCCGCGATCCGATCCGCTTCTGCCGCGGCGGCTCCCTGGAGA
GAGGGCGGCGAGGGCGCAGGGAAGAAGAGGGACGTCCACTGTGGAACATGAAGCAGCATGACTGAGAAAATGTCCAGCTTCCTCTACATA
GGGGACATCGTGTCCCTGTACGCGGAGGGCTCGGTCAACGGCTTCATCAGCACCTTGGGGTTAGTGGATGACAGATGTGTGGTGCACCCA
GAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCCCTATGAACAGATATTCTGCCCAGAAGCAA
TATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAACTACAGCACGCTGCAGAACTGGAACAAAAA
CAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATACAACTACTGCATATAAAAAGCAACAAATAT
CTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGGATGCTGCAGGAAATGAAGGGTCTTGGTTT
TATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAGTTGTTTTGATGCCTGTGAATGCAGGGCAG
CCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTGTCAATTGCAACACCAGCTGGAAAATCACT
TTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGATTATTTCATGCGGAACAAGAGAAGTTTTTG
ACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAGCTACTTCTGCTACTAGTTCTAAAGCACTC
TGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCTTGTTCAGATTTAAGCATCTTGCAACTGGA
AACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATGTGAGAGATGGAGTCCCTCCAACTTCAAAG
AAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATGACATTGCATCCCTTTTTGAACTAGATGCC
ACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATTTATGCACCAACACATGGGTAACCAGTACT
AGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAACCAAAGAAGATAAAGAAGCGTTCGCAATC
GTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTACTAGCGACCACAGTTAAAAAGCTAGAAAAC
GGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCTTTGTTGCTGATGTGCCTAATAATGGACAA
GAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAACAAAACATACTGGCACAGGTATTTGGAATT
CTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGGGGGATCAAAGATATGCACCCTACAAGTAC
ATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGGAATATATTGCTAAGAATTTCTGTGTCATG
CAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACAACAGAAAACTACTAGAGAAACATATCACA
GCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGGATTATTTGTCAGATCTGTGTGTGTCTAAT
ACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATGCAGACATTCTCATTCAAACTAAGGTGGTC
TCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAGAAGTTTGGCTCTATTGGATTGACAGCAAC
AAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAGCTGACTTAGAAGTTCTTACCTATTACAGG
TACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGATTTCTACACAGCTGTCTGTAGACCTGATC
CTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCATGCTCCACATGCACGTTGACCGGGATCCC
CAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCACAATTCATGAATATGATTCTATAACAGAC
TCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATTTGAAAGAAGTTGTAAACCAGCCCTTTCCT
TTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTATATACTTTGGATTTTATAGTTTCAGTGAG
TTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCATCATACTTTGAAAGATTAAGCAAATTTCAA
GATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGGTACTCAGTAGAGGCTCCATCTTCCCCATG
AGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACGAGGATGTGACTGTGATGGACACCAAGCTG
AAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATATGCTGTCAATATATAAGAAGGAGTTTGGA
GAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAGCTATTGTTCCTGATATAGATGAAATTGCA
GCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATGAAGGAGGCAGGACGTTTTTACGGGTCCTC
ATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTAAGCACTTCAGCCAGAGGGCAGAGGTTTTA
CAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAATCAAGGCAGATCTAGACCAGCTTCGACTG
ACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAGGGGAAAGTCAAGTGAAAGGTGGTGAAGAG
CCAATTGAGGAATCAAACATTTTAAGTCCAGTGCAGGATGGAACAAAGAAACCTCAGATTGACAGCAACAAGAGCAATAACTACCGGATT
GTAAAGGAGATTTTGATCAGGCTAAGTAAACTCTGTGTGCAGAATAAAAAGTGTCGGAATCAACATCAACGATTACTGAAAAATATGGGG
GCGCATTCGGTGGTGTTGGATCTTCTGCAGATACCCTATGAAAAGAATGATGAAAAGATGAATGAAGTAATGAATCTAGCCCATACATTT
CTGCAGAATTTCTGTCGAGGAAATCCACAGAATCAAGTTCTTCTTCATAAACATCTGAATTTGTTTTTAACTCCAGGTCTCCTTGAAGCA
GAAACCATGCGGCACATCTTCATGAACAATTACCATCTGTGCAACGAAATTAGCGAGAGAGTTGTACAACACTTTGTGCACTGCATTGAG
ACACATGGCCGCCACGTGGAGTACCTGAGGTTTTTGCAAACAATTGTAAAAGCAGATGGTAAATATGTGAAGAAATGCCAGGATATGGTA
ATGACAGAGTTGATAAATGGGGGTGAAGACGTGCTGATATTTTACAATGATAGAGCATCATTTCCAATCCTTCTCCATATGATGTGTTCA
GAGAGAGACCGAGGGGATGAGAGTGGCCCCTTAGCCTACCACATCACCCTGGTGGAGTTGCTGGCAGCATGCACAGAGGGGAAAAATGTC
TACACTGAAATCAAGTGTAATTCCCTTCTCCCGCTGGACGACATAGTGAGGGTGGTGACCCATGACGACTGCATCCCTGAGGTTAAAATT
GCTTATGTGAACTTTGTTAATCACTGTTATGTTGACACTGAAGTGGAAATGAAAGAAATCTATACAAGTAACCACATTTGGAAATTATTT
GAGAACTTCTTGGTGGATATGGCAAGGGTTTGCAACACAACTACAGACAGGAAACATGCAGACATCTTTTTGGAAAAGTGTGTTACTGAG
TCAATAATGAATATTGTGAGCGGCTTCTTTAATTCTCCCTTTTCAGACAATAGTACCAGCCTCCAGACACATCAGCCAGTTTTTATTCAG
CTACTGCAATCTGCCTTCAGAATTTACAATTGCACCTGGCCAAACCCAGCGCAGAAAGCCTCAGTGGAATCCTGTATCAGAACTTTGGCT
GAAGTGGCAAAAAATCGTGGAATTGCCATTCCAGTGGATTTGGACAGCCAAGTTAATACTCTTTTCATGAAGAGCCATTCAAATATGGTG
CAGAGAGCAGCAATGGGTTGGAGACTATCAGCTCGCTCTGGGCCACGCTTTAAGGAAGCTCTTGGAGGGCCTGCTTGGGATTACAGAAAT
ATTATTGAAAAGTTACAGGATGTAGTGGCCTCCTTGGAGCACCAGTTCAGCCCAATGATGCAGGCTGAATTCTCAGTGTTGGTTGATGTA
TTGTACAGTCCAGAACTGCTGTTCCCTGAGGGAAGCGATGCAAGAATAAGATGTGGCGCTTTCATGTCGAAGTTGATTAATCATACAAAG
AAACTAATGGAGAAAGAAGAAAAACTGTGCATTAAAATTCTTCAGACATTACGAGAAATGTTAGAGAAGAAAGACAGCTTTGTGGAAGAG
GGTAACACATTAAGAAAGATACTTCTGAATCGATACTTTAAAGGTGATTATAGTATTGGTGTGAATGGACACCTATCAGGAGCCTACTCC
AAAACTGCACAGGTGGGAGGAAGCTTTTCTGGACAAGATTCAGATAAGATGGGGATATCAATGTCAGACATTCAGTGTCTGCTGGATAAA
GAAGGTGCATCAGAACTTGTCATCGATGTTATAGTGAACACCAAAAATGACAGAATTTTTTCAGAAGGCATTTTCCTCGGCATTGCCTTG
CTTGAAGGAGGAAATACACAAACACAGTATTCTTTCTACCAGCAGTTGCATGAACAAAAAAAGTCAGAAAAATTCTTTAAAGTTCTCTAT
GATCGAATGAAGGCTGCTCAGAAAGAAATAAGATCAACAGTGACAGTTAATACCATAGATTTAGGTAACAAAAAAAGGGACGATGACAAT
GAATTGATGACATCTGGTCCACGAATGAGAGTAAGAGATTCAACACTACATTTAAAAGAGGGAATGAAAGGGCAATTAACAGAAGCTTCT
TCAGCAACATCCAAAGCATATTGTGTATACAGAAGAGAAATGGATCCAGAAATAGACATTATGTGCACAGGACCAGAAGCGGGAAACACT
GAGGAAAAATCCGCAGAGGAAGTAACAATGAGTCCCGCAATTGCCATCATGCAGCCAATACTGAGATTTCTTCAGTTACTGTGTGAGAAT
CACAACCGGGAATTGCAGAACTTCTTGAGGAATCAAAACAACAAAACAAATTACAACCTAGTCTGTGAGACCCTTCAGTTTCTGGACTGC
ATTTGTGGAAGTACAACCGGTGGCCTGGGCCTGTTGGGTCTCTACATCAATGAGAAGAATGTAGCGCTGGTCAACCAGAACCTGGAGAGC
TTGACTGAGTATTGCCAGGGCCCTTGCCATGAAAATCAGACCTGTATCGCTACACATGAGTCTAATGGGATTGATATCATCATTGCTTTG
ATTCTGAATGACATAAACCCTCTTGGTAAATACCGAATGGACCTGGTGCTCCAGCTAAAGAACAATGCATCTAAACTTTTGCTGGCCATT
ATGGAAAGCAGACATGACAGTGAGAATGCAGAAAGAATTCTTTTTAACATGAGACCCAGAGAACTGGTGGATGTGATGAAGAATGCCTAT
AACCAAGGATTGGAATGTGACCATGGGGATGATGAGGGTGGAGATGATGGTGTTTCTCCAAAAGATGTTGGACACAATATCTATATTCTG
GCCCATCAGTTGGCCCGCCACAATAAACTGTTGCAGCAGATGCTCAAACCAGGATCGGATCCAGATGAAGGAGATGAAGCCTTAAAGTAT
TATGCCAACCACACTGCACAGATTGAGATTGTCCGGCATGATAGGACCATGGAACAAATAGTTTTTCCTGTCCCCAATATATGTGAATAC
CTCACTCGAGAATCCAAGTGCCGTGTGTTCAATACAACTGAAAGGGATGAACAAGGAAGTAAAGTGAATGACTTTTTCCAGCAAACAGAA
GATCTCTACAATGAAATGAAGTGGCAGAAGAAAATCAGGAATAACCCTGCACTGTTCTGGTTCTCGAGGCACATCTCTCTCTGGGGGAGC
ATTTCCTTCAACCTGGCTGTGTTCATCAATTTAGCTGTTGCTCTCTTCTACCCATTTGGGGATGATGGAGATGAAGGTACACTTTCTCCA
TTGTTCTCGGTTCTTCTTTGGATAGCAGTTGCGATCTGCACATCTATGCTGTTTTTCTTCTCCAAGCCTGTGGGTATTCGGCCGTTTCTT
GTATCAATAATGCTCAGATCAATATATACAATAGGTCTTGGGCCTACATTAATACTTCTTGGTGCAGCTAATATGTACGAGATCAAAGCA
GGAGGCAGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAG
ATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGC
AGCCGCATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATC
TATGAGGCTGCCTACCCTCTTCATGACGGTGAATACGATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCG
CGCTATGGAGTGTTCTATAAGTTCCAACCTATTGACCTCATCAGAAAGTATTTTGGAGAAAAAATTGGACTGTATTTTGCCTGGCTGGGA
TTATATACATCATTCCTCATCCCATCTTCTGTAATTGGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGC
AGAGAGATGTGTGACCAGCAGAATGCCTTCACCATGTGTCCCCTGTGTGACAAGTCCTGTGATTACTGGAACCTCAGCTCAGCCTGTGGG
ACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGCCACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAAC
TGGAAGAGGCTACAGATGCGACTGGGCTACTTTTGGGACCTGACTGGCATAGAAGAGGAAGAAGAACGTGCCCAGGAACATTCCAGGCCT
GAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGC
GATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTG
ACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGG
GTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACC
AAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCC
ATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGT
GCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATT
GGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAG
CAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTC
TTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAG
CTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAAC
GCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTC
AACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGC
AGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCT
TTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAG
ATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGC
CCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCT
CAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACGGCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACC
CACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTGAAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGA
GTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTTAAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGG
GATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGCGAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACC
ATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCACAGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACT
TGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGGCTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGG
TCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGCTAAATGCAGATAACCATCATTTTATGAAAGTTCAGATTTAAA

>40690_40690_1_ITPR2-ANO2_ITPR2_chr12_26580846_ENST00000381340_ANO2_chr12_5941769_ENST00000327087_length(amino acids)=3106AA_BP=2315
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLK
KLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQ
SATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRF
LDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTK
ITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRIS
YMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQ
IDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRA
SFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQK
ASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSI
GVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEID
IMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK
NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRP
RELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF
GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANMYEIKAGGSIAKKFSAALQKLSSHL
QPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDM
NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKS
CDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAV
QKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILD
EIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLG
KQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIE
VRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPE
NSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK

--------------------------------------------------------------
>40690_40690_2_ITPR2-ANO2_ITPR2_chr12_26580846_ENST00000381340_ANO2_chr12_5941769_ENST00000356134_length(transcript)=10383nt_BP=7362nt
CTTCCAGCTCCCGCCGGGCGGCTGTGACGGCCGCAGCGGGTCGCAGAGCAGGGAGTGGACACGGAGTGGGGAGCGGAGAGGGAAGGAGGA
GGAGGAGGAGCAAAGGTGTTGGAGAGAAAACTTCAGAAAGGAACAGGAAACCTGCCGGGGAGGCGGCGGCGGCTGCGGCTTCTCTGGGCG
CCTGGGCTGCGCTCTTCGCGGGGTGTCCGCAGCTGCGGCTTGGCCCCGGTCTGGCTTCCCCGGCGCGCACGCACGGCTGAGCCGCGACGC
TCAGTGGCTCGGGCCGTGCCCTCCGCCGCGGCTCTTGGCCGCTGTAGTCCCGCGATCCGATCCGCTTCTGCCGCGGCGGCTCCCTGGAGA
GAGGGCGGCGAGGGCGCAGGGAAGAAGAGGGACGTCCACTGTGGAACATGAAGCAGCATGACTGAGAAAATGTCCAGCTTCCTCTACATA
GGGGACATCGTGTCCCTGTACGCGGAGGGCTCGGTCAACGGCTTCATCAGCACCTTGGGGTTAGTGGATGACAGATGTGTGGTGCACCCA
GAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCCCTATGAACAGATATTCTGCCCAGAAGCAA
TATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAACTACAGCACGCTGCAGAACTGGAACAAAAA
CAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATACAACTACTGCATATAAAAAGCAACAAATAT
CTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGGATGCTGCAGGAAATGAAGGGTCTTGGTTT
TATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAGTTGTTTTGATGCCTGTGAATGCAGGGCAG
CCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTGTCAATTGCAACACCAGCTGGAAAATCACT
TTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGATTATTTCATGCGGAACAAGAGAAGTTTTTG
ACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAGCTACTTCTGCTACTAGTTCTAAAGCACTC
TGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCTTGTTCAGATTTAAGCATCTTGCAACTGGA
AACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATGTGAGAGATGGAGTCCCTCCAACTTCAAAG
AAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATGACATTGCATCCCTTTTTGAACTAGATGCC
ACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATTTATGCACCAACACATGGGTAACCAGTACT
AGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAACCAAAGAAGATAAAGAAGCGTTCGCAATC
GTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTACTAGCGACCACAGTTAAAAAGCTAGAAAAC
GGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCTTTGTTGCTGATGTGCCTAATAATGGACAA
GAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAACAAAACATACTGGCACAGGTATTTGGAATT
CTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGGGGGATCAAAGATATGCACCCTACAAGTAC
ATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGGAATATATTGCTAAGAATTTCTGTGTCATG
CAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACAACAGAAAACTACTAGAGAAACATATCACA
GCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGGATTATTTGTCAGATCTGTGTGTGTCTAAT
ACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATGCAGACATTCTCATTCAAACTAAGGTGGTC
TCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAGAAGTTTGGCTCTATTGGATTGACAGCAAC
AAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAGCTGACTTAGAAGTTCTTACCTATTACAGG
TACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGATTTCTACACAGCTGTCTGTAGACCTGATC
CTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCATGCTCCACATGCACGTTGACCGGGATCCC
CAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCACAATTCATGAATATGATTCTATAACAGAC
TCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATTTGAAAGAAGTTGTAAACCAGCCCTTTCCT
TTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTATATACTTTGGATTTTATAGTTTCAGTGAG
TTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCATCATACTTTGAAAGATTAAGCAAATTTCAA
GATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGGTACTCAGTAGAGGCTCCATCTTCCCCATG
AGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACGAGGATGTGACTGTGATGGACACCAAGCTG
AAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATATGCTGTCAATATATAAGAAGGAGTTTGGA
GAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAGCTATTGTTCCTGATATAGATGAAATTGCA
GCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATGAAGGAGGCAGGACGTTTTTACGGGTCCTC
ATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTAAGCACTTCAGCCAGAGGGCAGAGGTTTTA
CAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAATCAAGGCAGATCTAGACCAGCTTCGACTG
ACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAGGGGAAAGTCAAGTGAAAGGTGGTGAAGAG
CCAATTGAGGAATCAAACATTTTAAGTCCAGTGCAGGATGGAACAAAGAAACCTCAGATTGACAGCAACAAGAGCAATAACTACCGGATT
GTAAAGGAGATTTTGATCAGGCTAAGTAAACTCTGTGTGCAGAATAAAAAGTGTCGGAATCAACATCAACGATTACTGAAAAATATGGGG
GCGCATTCGGTGGTGTTGGATCTTCTGCAGATACCCTATGAAAAGAATGATGAAAAGATGAATGAAGTAATGAATCTAGCCCATACATTT
CTGCAGAATTTCTGTCGAGGAAATCCACAGAATCAAGTTCTTCTTCATAAACATCTGAATTTGTTTTTAACTCCAGGTCTCCTTGAAGCA
GAAACCATGCGGCACATCTTCATGAACAATTACCATCTGTGCAACGAAATTAGCGAGAGAGTTGTACAACACTTTGTGCACTGCATTGAG
ACACATGGCCGCCACGTGGAGTACCTGAGGTTTTTGCAAACAATTGTAAAAGCAGATGGTAAATATGTGAAGAAATGCCAGGATATGGTA
ATGACAGAGTTGATAAATGGGGGTGAAGACGTGCTGATATTTTACAATGATAGAGCATCATTTCCAATCCTTCTCCATATGATGTGTTCA
GAGAGAGACCGAGGGGATGAGAGTGGCCCCTTAGCCTACCACATCACCCTGGTGGAGTTGCTGGCAGCATGCACAGAGGGGAAAAATGTC
TACACTGAAATCAAGTGTAATTCCCTTCTCCCGCTGGACGACATAGTGAGGGTGGTGACCCATGACGACTGCATCCCTGAGGTTAAAATT
GCTTATGTGAACTTTGTTAATCACTGTTATGTTGACACTGAAGTGGAAATGAAAGAAATCTATACAAGTAACCACATTTGGAAATTATTT
GAGAACTTCTTGGTGGATATGGCAAGGGTTTGCAACACAACTACAGACAGGAAACATGCAGACATCTTTTTGGAAAAGTGTGTTACTGAG
TCAATAATGAATATTGTGAGCGGCTTCTTTAATTCTCCCTTTTCAGACAATAGTACCAGCCTCCAGACACATCAGCCAGTTTTTATTCAG
CTACTGCAATCTGCCTTCAGAATTTACAATTGCACCTGGCCAAACCCAGCGCAGAAAGCCTCAGTGGAATCCTGTATCAGAACTTTGGCT
GAAGTGGCAAAAAATCGTGGAATTGCCATTCCAGTGGATTTGGACAGCCAAGTTAATACTCTTTTCATGAAGAGCCATTCAAATATGGTG
CAGAGAGCAGCAATGGGTTGGAGACTATCAGCTCGCTCTGGGCCACGCTTTAAGGAAGCTCTTGGAGGGCCTGCTTGGGATTACAGAAAT
ATTATTGAAAAGTTACAGGATGTAGTGGCCTCCTTGGAGCACCAGTTCAGCCCAATGATGCAGGCTGAATTCTCAGTGTTGGTTGATGTA
TTGTACAGTCCAGAACTGCTGTTCCCTGAGGGAAGCGATGCAAGAATAAGATGTGGCGCTTTCATGTCGAAGTTGATTAATCATACAAAG
AAACTAATGGAGAAAGAAGAAAAACTGTGCATTAAAATTCTTCAGACATTACGAGAAATGTTAGAGAAGAAAGACAGCTTTGTGGAAGAG
GGTAACACATTAAGAAAGATACTTCTGAATCGATACTTTAAAGGTGATTATAGTATTGGTGTGAATGGACACCTATCAGGAGCCTACTCC
AAAACTGCACAGGTGGGAGGAAGCTTTTCTGGACAAGATTCAGATAAGATGGGGATATCAATGTCAGACATTCAGTGTCTGCTGGATAAA
GAAGGTGCATCAGAACTTGTCATCGATGTTATAGTGAACACCAAAAATGACAGAATTTTTTCAGAAGGCATTTTCCTCGGCATTGCCTTG
CTTGAAGGAGGAAATACACAAACACAGTATTCTTTCTACCAGCAGTTGCATGAACAAAAAAAGTCAGAAAAATTCTTTAAAGTTCTCTAT
GATCGAATGAAGGCTGCTCAGAAAGAAATAAGATCAACAGTGACAGTTAATACCATAGATTTAGGTAACAAAAAAAGGGACGATGACAAT
GAATTGATGACATCTGGTCCACGAATGAGAGTAAGAGATTCAACACTACATTTAAAAGAGGGAATGAAAGGGCAATTAACAGAAGCTTCT
TCAGCAACATCCAAAGCATATTGTGTATACAGAAGAGAAATGGATCCAGAAATAGACATTATGTGCACAGGACCAGAAGCGGGAAACACT
GAGGAAAAATCCGCAGAGGAAGTAACAATGAGTCCCGCAATTGCCATCATGCAGCCAATACTGAGATTTCTTCAGTTACTGTGTGAGAAT
CACAACCGGGAATTGCAGAACTTCTTGAGGAATCAAAACAACAAAACAAATTACAACCTAGTCTGTGAGACCCTTCAGTTTCTGGACTGC
ATTTGTGGAAGTACAACCGGTGGCCTGGGCCTGTTGGGTCTCTACATCAATGAGAAGAATGTAGCGCTGGTCAACCAGAACCTGGAGAGC
TTGACTGAGTATTGCCAGGGCCCTTGCCATGAAAATCAGACCTGTATCGCTACACATGAGTCTAATGGGATTGATATCATCATTGCTTTG
ATTCTGAATGACATAAACCCTCTTGGTAAATACCGAATGGACCTGGTGCTCCAGCTAAAGAACAATGCATCTAAACTTTTGCTGGCCATT
ATGGAAAGCAGACATGACAGTGAGAATGCAGAAAGAATTCTTTTTAACATGAGACCCAGAGAACTGGTGGATGTGATGAAGAATGCCTAT
AACCAAGGATTGGAATGTGACCATGGGGATGATGAGGGTGGAGATGATGGTGTTTCTCCAAAAGATGTTGGACACAATATCTATATTCTG
GCCCATCAGTTGGCCCGCCACAATAAACTGTTGCAGCAGATGCTCAAACCAGGATCGGATCCAGATGAAGGAGATGAAGCCTTAAAGTAT
TATGCCAACCACACTGCACAGATTGAGATTGTCCGGCATGATAGGACCATGGAACAAATAGTTTTTCCTGTCCCCAATATATGTGAATAC
CTCACTCGAGAATCCAAGTGCCGTGTGTTCAATACAACTGAAAGGGATGAACAAGGAAGTAAAGTGAATGACTTTTTCCAGCAAACAGAA
GATCTCTACAATGAAATGAAGTGGCAGAAGAAAATCAGGAATAACCCTGCACTGTTCTGGTTCTCGAGGCACATCTCTCTCTGGGGGAGC
ATTTCCTTCAACCTGGCTGTGTTCATCAATTTAGCTGTTGCTCTCTTCTACCCATTTGGGGATGATGGAGATGAAGGTACACTTTCTCCA
TTGTTCTCGGTTCTTCTTTGGATAGCAGTTGCGATCTGCACATCTATGCTGTTTTTCTTCTCCAAGCCTGTGGGTATTCGGCCGTTTCTT
GTATCAATAATGCTCAGATCAATATATACAATAGGTCTTGGGCCTACATTAATACTTCTTGGTGCAGCTAATATGTACGAGATCAAAGCA
GGAGGCAGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAG
ATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGC
AGCCGCATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATC
TATGAGGCTGCCTACCCTCTTCATGACGGTGAATACGATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCG
CGCTATGGAGTGTTCTATAAGTTCCAACCTATTGACCTCATCAGAAAGTATTTTGGAGAAAAAATTGGACTGTATTTTGCCTGGCTGGGA
TTATATACATCATTCCTCATCCCATCTTCTGTAATTGGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGC
AGAGAGATGTGTGACCAGCAGAATGCCTTCACCATGTGTCCCCTGTGTGACAAGTCCTGTGATTACTGGAACCTCAGCTCAGCCTGTGGG
ACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGCCACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAAC
TGGAAGAGGCTACAGATGCGACTGGGCTACTTTTGGGACCTGACTGGCATAGAAGAGGAAGAAGAACGTGCCCAGGAACATTCCAGGCCT
GAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGC
GATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTG
ACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGG
GTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACC
AAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCC
ATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGT
GCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATT
GGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAG
CAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTC
TTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAG
CTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAAC
GCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTC
AACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGC
AGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCT
TTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAG
ATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGC
CCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCT
CAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACGGCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACC
CACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTGAAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGA
GTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTTAAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGG
GATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGCGAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACC
ATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCACAGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACT
TGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGGCTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGG
TCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGCTAAATGCAGATAACCATCATTTTATGAAAGTTCAGATTTAAA

>40690_40690_2_ITPR2-ANO2_ITPR2_chr12_26580846_ENST00000381340_ANO2_chr12_5941769_ENST00000356134_length(amino acids)=3106AA_BP=2315
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLK
KLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQ
SATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRF
LDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTK
ITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRIS
YMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQ
IDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRA
SFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQK
ASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSI
GVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEID
IMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK
NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRP
RELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF
GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANMYEIKAGGSIAKKFSAALQKLSSHL
QPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDM
NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKS
CDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAV
QKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILD
EIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLG
KQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIE
VRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPE
NSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK

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Fusion Gene PPI Analysis for ITPR2-ANO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITPR2-ANO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITPR2-ANO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource