FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ITPR3-MICA (FusionGDB2 ID:40723)

Fusion Gene Summary for ITPR3-MICA

check button Fusion gene summary
Fusion gene informationFusion gene name: ITPR3-MICA
Fusion gene ID: 40723
HgeneTgene
Gene symbol

ITPR3

MICA

Gene ID

3710

100507436

Gene nameinositol 1,4,5-trisphosphate receptor type 3MHC class I polypeptide-related sequence A
SynonymsIP3R|IP3R3MIC-A|PERB11.1
Cytomap

6p21.31

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioninositol 1,4,5-trisphosphate receptor type 3IP3 receptorinositol 1,4,5-triphosphate receptor, type 3insP3R3type 3 InsP3 receptorMHC class I polypeptide-related sequence AHLA class I antigenMHC class I chain-related protein AMHC class I related chain AMHC class I related sequence Amajor histocompatibility complex class I chain-related protein Astress inducible class I homolog
Modification date2020031320200313
UniProtAcc.

Q8IY33

Ensembl transtripts involved in fusion geneENST00000374316, ENST00000605930, 
ENST00000449934, ENST00000400322, 
ENST00000400325, ENST00000414473, 
ENST00000415525, ENST00000417899, 
ENST00000418465, ENST00000420259, 
ENST00000427477, ENST00000432479, 
ENST00000438928, ENST00000446505, 
ENST00000468858, ENST00000486844, 
ENST00000493320, ENST00000497496, 
ENST00000546529, ENST00000547609, 
ENST00000547767, ENST00000552236, 
Fusion gene scores* DoF score14 X 13 X 8=14566 X 6 X 5=180
# samples 157
** MAII scorelog2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITPR3 [Title/Abstract] AND MICA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITPR3(33589468)-MICA(31382789), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITPR3

GO:0051592

response to calcium ion

19052258

TgeneMICA

GO:0001913

T cell mediated cytotoxicity

10426993

TgeneMICA

GO:0002418

immune response to tumor cell

10359807

TgeneMICA

GO:0006974

cellular response to DNA damage stimulus

15995699

TgeneMICA

GO:0009408

response to heat

8901601

TgeneMICA

GO:0032815

negative regulation of natural killer cell activation

20068167

TgeneMICA

GO:0042267

natural killer cell mediated cytotoxicity

10426993

TgeneMICA

GO:0042742

defense response to bacterium

11485740|11830641

TgeneMICA

GO:0046629

gamma-delta T cell activation

9497295

TgeneMICA

GO:0051607

defense response to virus

11224526|16750166


check buttonFusion gene breakpoints across ITPR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MICA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5724-01AITPR3chr6

33589468

+MICAchr6

31382789

+


Top

Fusion Gene ORF analysis for ITPR3-MICA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000374316ENST00000449934ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-3UTRENST00000605930ENST00000449934ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000400322ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000400325ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000414473ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000415525ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000417899ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000418465ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000420259ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000427477ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000432479ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000438928ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000446505ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000468858ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000486844ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000493320ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000497496ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000546529ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000547609ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000547767ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000374316ENST00000552236ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000400322ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000400325ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000414473ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000415525ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000417899ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000418465ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000420259ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000427477ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000432479ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000438928ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000446505ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000468858ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000486844ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000493320ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000497496ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000546529ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000547609ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000547767ITPR3chr6

33589468

+MICAchr6

31382789

+
5CDS-intronENST00000605930ENST00000552236ITPR3chr6

33589468

+MICAchr6

31382789

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ITPR3-MICA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITPR3chr633589468+MICAchr631382788+3.68E-050.9999633
ITPR3chr633589468+MICAchr631382788+3.68E-050.9999633

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ITPR3-MICA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33589468/:31382789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MICA

Q8IY33

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ITPR3-MICA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ITPR3-MICA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ITPR3-MICA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ITPR3-MICA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource