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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IVNS1ABP-GRSF1 (FusionGDB2 ID:40790)

Fusion Gene Summary for IVNS1ABP-GRSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: IVNS1ABP-GRSF1
Fusion gene ID: 40790
HgeneTgene
Gene symbol

IVNS1ABP

GRSF1

Gene ID

10625

2926

Gene nameinfluenza virus NS1A binding proteinG-rich RNA sequence binding factor 1
SynonymsARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP-
Cytomap

1q25.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioninfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39G-rich sequence factor 1
Modification date2020032020200313
UniProtAcc

Q9Y6Y0

Q12849

Ensembl transtripts involved in fusion geneENST00000367497, ENST00000367498, 
ENST00000392007, ENST00000459929, 
ENST00000254799, ENST00000439371, 
ENST00000502323, ENST00000508091, 
ENST00000545193, 
Fusion gene scores* DoF score6 X 7 X 1=4211 X 10 X 4=440
# samples 711
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IVNS1ABP [Title/Abstract] AND GRSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIVNS1ABP(185266657)-GRSF1(71685543), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRSF1

GO:0000962

positive regulation of mitochondrial RNA catabolic process

29967381


check buttonFusion gene breakpoints across IVNS1ABP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE173356IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+


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Fusion Gene ORF analysis for IVNS1ABP-GRSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367497ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367497ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367498ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367498ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000392007ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000392007ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000459929ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000459929ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IVNS1ABP-GRSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IVNS1ABP-GRSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:185266657/:71685543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IVNS1ABP

Q9Y6Y0

GRSF1

Q12849

FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:9696811}.FUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IVNS1ABP-GRSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IVNS1ABP-GRSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IVNS1ABP-GRSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IVNS1ABP-GRSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource