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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:JAK2-DOCK8 (FusionGDB2 ID:40852)

Fusion Gene Summary for JAK2-DOCK8

check button Fusion gene summary
Fusion gene informationFusion gene name: JAK2-DOCK8
Fusion gene ID: 40852
HgeneTgene
Gene symbol

JAK2

DOCK8

Gene ID

3717

81704

Gene nameJanus kinase 2dedicator of cytokinesis 8
SynonymsJTK10|THCYT3HEL-205|MRD2|ZIR8
Cytomap

9p24.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)dedicator of cytokinesis protein 81200017A24Rikepididymis luminal protein 205
Modification date2020032920200327
UniProtAcc.

Q8NF50

Ensembl transtripts involved in fusion geneENST00000381652, ENST00000539801, 
ENST00000544510, ENST00000487310, 
ENST00000432829, ENST00000469391, 
ENST00000382329, ENST00000382331, 
ENST00000493666, ENST00000453981, 
Fusion gene scores* DoF score13 X 10 X 8=10409 X 14 X 10=1260
# samples 1116
** MAII scorelog2(11/1040*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JAK2 [Title/Abstract] AND DOCK8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK8(340321)-JAK2(5050686), # samples:3
JAK2(5055788)-DOCK8(286461), # samples:3
Anticipated loss of major functional domain due to fusion event.DOCK8-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DOCK8-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DOCK8-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DOCK8-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJAK2

GO:0010811

positive regulation of cell-substrate adhesion

10925297

HgeneJAK2

GO:0019221

cytokine-mediated signaling pathway

8609418

HgeneJAK2

GO:0033209

tumor necrosis factor-mediated signaling pathway

8609418

HgeneJAK2

GO:0034612

response to tumor necrosis factor

8609418

HgeneJAK2

GO:0035409

histone H3-Y41 phosphorylation

19783980

HgeneJAK2

GO:0035722

interleukin-12-mediated signaling pathway

7528775

HgeneJAK2

GO:0046677

response to antibiotic

16280321

HgeneJAK2

GO:0050727

regulation of inflammatory response

10925297

HgeneJAK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgeneJAK2

GO:0070671

response to interleukin-12

7528775

TgeneDOCK8

GO:0043547

positive regulation of GTPase activity

28028151


check buttonFusion gene breakpoints across JAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-WE-A8ZN-06AJAK2chr9

5055788

-DOCK8chr9

286461

+
ChimerDB4SKCMTCGA-WE-A8ZN-06AJAK2chr9

5055788

+DOCK8chr9

286461

+


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Fusion Gene ORF analysis for JAK2-DOCK8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000381652ENST00000432829JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-5UTRENST00000381652ENST00000469391JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-5UTRENST00000539801ENST00000432829JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-5UTRENST00000539801ENST00000469391JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-5UTRENST00000544510ENST00000432829JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-5UTRENST00000544510ENST00000469391JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000381652ENST00000382329JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000381652ENST00000382331JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000381652ENST00000493666JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000539801ENST00000382329JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000539801ENST00000382331JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000539801ENST00000493666JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000544510ENST00000382329JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000544510ENST00000382331JAK2chr9

5055788

+DOCK8chr9

286461

+
5CDS-intronENST00000544510ENST00000493666JAK2chr9

5055788

+DOCK8chr9

286461

+
In-frameENST00000381652ENST00000453981JAK2chr9

5055788

+DOCK8chr9

286461

+
In-frameENST00000539801ENST00000453981JAK2chr9

5055788

+DOCK8chr9

286461

+
In-frameENST00000544510ENST00000453981JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-3CDSENST00000487310ENST00000453981JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-5UTRENST00000487310ENST00000432829JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-5UTRENST00000487310ENST00000469391JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-intronENST00000487310ENST00000382329JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-intronENST00000487310ENST00000382331JAK2chr9

5055788

+DOCK8chr9

286461

+
intron-intronENST00000487310ENST00000493666JAK2chr9

5055788

+DOCK8chr9

286461

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539801JAK2chr95055788+ENST00000453981DOCK8chr9286461+8349116911373122399
ENST00000381652JAK2chr95055788+ENST00000453981DOCK8chr9286461+8730155049476932399
ENST00000544510JAK2chr95055788+ENST00000453981DOCK8chr9286461+816098026071232287

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539801ENST00000453981JAK2chr95055788+DOCK8chr9286461+0.0005408060.9994592
ENST00000381652ENST00000453981JAK2chr95055788+DOCK8chr9286461+0.0008010870.999199
ENST00000544510ENST00000453981JAK2chr95055788+DOCK8chr9286461+0.0008514250.9991486

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Fusion Genomic Features for JAK2-DOCK8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
JAK2chr95055788+DOCK8chr9286460+5.18E-070.9999995
JAK2chr95055788+DOCK8chr9286460+5.18E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for JAK2-DOCK8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:340321/chr9:5050686)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK8

Q8NF50

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDOCK8chr9:5055788chr9:286461ENST000004328291481632_206602032.0DomainDOCKER
TgeneDOCK8chr9:5055788chr9:286461ENST00000432829148560_72902032.0DomainC2 DOCK-type
TgeneDOCK8chr9:5055788chr9:286461ENST000004539811481632_2066522100.0DomainDOCKER
TgeneDOCK8chr9:5055788chr9:286461ENST00000453981148560_729522100.0DomainC2 DOCK-type
TgeneDOCK8chr9:5055788chr9:286461ENST000004693910461632_206602000.0DomainDOCKER
TgeneDOCK8chr9:5055788chr9:286461ENST00000469391046560_72902000.0DomainC2 DOCK-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+82537_3803521133.0DomainFERM
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+825401_4823521133.0DomainSH2%3B atypical
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+825545_8093521133.0DomainProtein kinase 1
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+825849_11243521133.0DomainProtein kinase 2
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+72437_3803521133.0DomainFERM
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+724401_4823521133.0DomainSH2%3B atypical
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+724545_8093521133.0DomainProtein kinase 1
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+724849_11243521133.0DomainProtein kinase 2
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+825855_8633521133.0Nucleotide bindingATP
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+724855_8633521133.0Nucleotide bindingATP


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Fusion Gene Sequence for JAK2-DOCK8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40852_40852_1_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000381652_DOCK8_chr9_286461_ENST00000453981_length(transcript)=8730nt_BP=1550nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGCCTCAGTTTTATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCTGAACAGCCTGG
ATGTGCAGCTTGCCCAGGAGCTCGGGGACTTCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGACTTTGCAGCCCT
CTTTGCCGGAGGAAGGGGTTGAACTGGACCCTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGTGAACCGGAAAA
ACCAAGGAAGTCCAGAAATCTGTGGCTTTAAAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGACGTTTGAGTCGG
AAACCTTGGAGTGCAGTGAACCCGCTGCTCAGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGGCCCCGTCACTG
CCTGTGACTTTGACCTCCGCAGCCTGCAGCCTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTTTGAGAAGCAGA
ACGAGGAGGCCCGGAGGACCAATAGGCAGGCCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGAAATACGTCCAG
TACCAGAATGTCCCAAGGAACACCTGGGCAACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGAGCCCCTGTTTG
CCAGCATTGCCCTCTACGATGTTAAAGAAAGGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTTCAAAGGATTTC
TGCGAGCTCACACGCCTTCAGTGGCCGCATCAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGACATCTACCTGG
TAGTCAAGATTGAAAAAGTCCTGCAGCAGGGAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGATGGTGGAAAGA
GTAAAGAAAAGATTGAAAAACTAAAACTCCAAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGCCTGGGCACCCA
TAAGCTTATCAAGCTTCTTCAATGTCTCCACCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTCAGTGGGTGAAC
GGAGGACATTGGCCCAATCTAGAAGGCTTTCTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAAAACCTCCACTC
TGAGCGTTAGCAGCTTTTTCAAGCAGGAAGGAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAAAAGATCATCAT
CCTTACAGAGACGAGTCAAGTCAATTCCAGGCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTGTCTGACTCCTG
AAATGCTGCCCGTGAAACCCTTTCCTGAAAACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGTATATGTCCCTC
ACACTGTGTACAGAAACCTTCTCTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGA
TCCAGTTTATGTGTGGAGAAGATGCTAGCAATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACA
CAGCTGTTACATACCATAATAAGTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCACCTCC
TGTTCACCTTCTACCATATCAGCTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTCTTAA
ATGAACGTCTTCAAACTGGATCCTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCC
CATTACAGAATCCTCCCATTAAGTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGG
ACAACCACCTGGAGAAGTTCTTCACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCG
AGATGGCGCTGGAGCATGAGCTGAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGC
TGGACAAGCTCTTCCAGCTGTCCGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGG
CCATCGCCAACAGTCTGCACAACAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCT
TCCGCCTGCCAGAGGTGCAAAGGGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCA
CATCAGCTGCTGCTGTGAGTTCAAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAG
ACGAGGAAGTGAAGAACATCATGTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTC
CAAGTTCACCTGCAGCCCCAAGGCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGA
GAGAAACAGTCTTCAAGTATGCCTGGTTCTTCTTTGAGCTTCTGGTGAAAAGCATGGCCCAGCACGTACATAACATGGACAAACGGGACA
GTTTTCGGAGGACTCGTTTTTCTGACCGTTTCATGGATGACATAACTACTATTGTTAATGTGGTCACCTCGGAAATTGCAGCCCTTTTAG
TAAAACCACAGAAGGAAAATGAACAGGCGGAAAAGATGAACATCAGCCTGGCTTTCTTCTTGTATGACCTTCTCTCCCTCATGGATCGGG
GCTTTGTGTTTAACCTCATCAGACATTATTGCAGCCAGCTGTCAGCCAAGCTCAGTAACCTTCCAACGCTCATTTCCATGAGGCTAGAGT
TCCTGAGAATCCTCTGTAGCCATGAGCATTACCTCAATCTGAACCTTTTTTTTATGAATGCTGATACTGCTCCAACATCTCCTTGTCCTT
CCATATCTTCCCAGAACTCAAGCTCCTGCTCCAGCTTCCAGGACCAGAAGATCGCCAGCATGTTCGATCTGACTTCCGAGTACCGCCAGC
AGCACTTCCTCACCGGGCTCCTCTTCACAGAACTGGCTGCTGCCCTGGATGCCGAAGGGGAAGGAATCAGCAAAGTACAAAGGAAAGCTG
TCAGTGCAATTCACAGCCTGCTAAGTTCTCACGACCTGGACCCACGCTGTGTCAAACCAGAGGTGAAGGTCAAAATCGCCGCCCTTTACC
TACCTTTAGTTGGCATCATTTTGGATGCTTTGCCACAGCTCTGTGACTTTACAGTTGCAGATACTCGCAGATACCGCACCAGTGGCTCGG
ATGAAGAACAAGAAGGAGCCGGTGCCATTAACCAGAATGTGGCTCTGGCCATAGCAGGGAATAATTTCAATTTGAAAACAAGTGGAATAG
TGCTGTCTTCCTTGCCCTATAAGCAGTACAACATGCTGAACGCGGACACTACTCGCAACCTCATGATCTGCTTCCTCTGGATCATGAAAA
ATGCTGATCAGAGCCTCATTAGGAAGTGGATTGCTGACCTGCCATCAACGCAGCTCAACAGGATTTTAGATCTACTTTTCATCTGTGTGT
TATGTTTTGAGTATAAGGGAAAACAGAGTTCTGACAAAGTCAGTACCCAAGTCCTGCAGAAGTCAAGGGATGTCAAGGCCCGGCTGGAAG
AGGCTTTGCTCCGTGGGGAAGGGGCCAGAGGGGAGATGATGCGCCGCCGGGCTCCAGGGAACGACCGATTTCCAGGCCTAAATGAAAATT
TGAGATGGAAGAAAGAGCAGACACATTGGCGGCAAGCTAATGAGAAGCTAGATAAAACAAAGGCCGAGTTAGATCAAGAAGCCTTGATCA
GTGGCAATCTGGCTACAGAAGCACATTTAATCATCCTGGATATGCAGGAAAACATTATCCAGGCGAGCTCGGCTCTGGACTGTAAAGACA
GCCTGCTGGGAGGTGTTCTGAGGGTGCTGGTGAATTCTCTGAACTGTGATCAGAGTACCACCTACCTGACTCACTGCTTTGCAACACTCC
GTGCTCTCATCGCCAAGTTTGGAGACTTACTCTTTGAAGAGGAGGTGGAACAGTGTTTCGACCTATGTCACCAAGTCCTGCACCACTGCA
GCAGCAGCATGGATGTCACCCGGAGCCAAGCCTGTGCCACCCTTTACCTCCTCATGAGGTTCAGTTTTGGAGCCACCAGTAATTTTGCAA
GAGTAAAGATGCAAGTAACCATGTCCCTGGCATCTTTGGTGGGAAGAGCACCAGACTTTAATGAAGAGCACCTGAGAAGATCCTTGAGGA
CAATTTTGGCCTATTCAGAAGAGGACACAGCCATGCAGATGACTCCTTTTCCCACCCAGGTGGAGGAACTTCTCTGTAATCTGAATAGCA
TCTTATATGACACAGTGAAAATGAGGGAATTTCAGGAAGATCCTGAGATGCTTATGGATCTCATGTACAGAATTGCCAAGAGTTACCAGG
CATCTCCTGATCTGCGGCTGACCTGGCTCCAGAACATGGCAGAGAAACACACCAAGAAGAAGTGCTACACGGAGGCTGCCATGTGCCTGG
TGCACGCCGCTGCGTTAGTGGCTGAGTATCTGAGCATGCTGGAGGACCACAGCTACCTGCCCGTGGGCAGTGTCAGCTTCCAGAATATTT
CTTCCAATGTGCTGGAGGAGTCTGTGGTCTCTGAGGACACCCTGTCACCTGACGAGGATGGGGTGTGCGCAGGCCAGTACTTCACCGAGA
GTGGCCTGGTAGGCCTCCTGGAGCAGGCCGCGGAGCTCTTCAGCACGGGAGGCTTATATGAGACAGTTAATGAGGTCTACAAGCTGGTCA
TCCCCATCCTAGAAGCGCATCGAGAATTCCGGAAGCTGACACTCACTCACAGCAAGCTGCAGAGAGCCTTCGACAGCATCGTTAACAAGG
ATCATAAGAGAATGTTTGGAACCTACTTCCGAGTTGGTTTCTTTGGATCCAAATTTGGGGATTTGGATGAACAGGAGTTTGTCTACAAAG
AGCCTGCAATTACCAAGCTTCCTGAGATCTCACATAGACTAGAGGCATTTTATGGTCAATGTTTTGGTGCAGAATTTGTGGAAGTGATTA
AAGACTCCACTCCTGTGGACAAAACCAAGTTGGATCCTAACAAGGCCTACATACAGATCACTTTTGTGGAGCCCTACTTTGATGAGTATG
AGATGAAAGACAGGGTCACATACTTTGAGAAGAATTTCAACCTCCGGAGGTTCATGTACACCACCCCGTTCACCCTGGAGGGGCGGCCTC
GGGGAGAGCTGCATGAGCAGTACAGAAGGAACACAGTCCTGACCACTATGCACGCCTTCCCCTACATCAAGACCAGGATCAGCGTCATCC
AGAAGGAGGAGTTTGTTTTGACACCGATTGAAGTTGCCATTGAAGACATGAAGAAGAAGACCCTGCAGTTAGCAGTTGCCATTAACCAGG
AGCCGCCTGATGCAAAGATGCTTCAGATGGTGCTGCAAGGCTCTGTGGGAGCTACTGTAAATCAGGGACCACTGGAAGTAGCCCAAGTGT
TTTTGGCTGAAATTCCTGCTGATCCAAAACTCTATCGACATCACAACAAGTTGAGGTTATGCTTTAAGGAATTCATCATGAGATGTGGTG
AAGCTGTAGAGAAAAACAAGCGTCTCATCACGGCAGACCAGAGGGAATATCAGCAGGAACTCAAAAAGAACTATAACAAGCTAAAAGAGA
ACCTCAGGCCAATGATCGAGCGGAAAATTCCAGAACTGTACAAGCCAATATTCAGAGTTGAGAGTCAAAAGAGGGACTCCTTCCACAGAT
CTAGTTTCAGGAAATGTGAAACCCAGTTGTCACAGGGCAGCTAAGAAAAGCCATCTTCATTCGTGGAGACTGTGGCCCTGCAACCCTGGA
GAAGGACTTGCTGGTACTTAAAAAATGGGACATTTGCCACCCAGGACTGACTGTACACTCCCTGATCAGCCAGCACTCTGGAAGCTTTGG
GATCCCAGGAACCATGGAATTATTCCCAAATGGACTCTGACCAGATTTTTGCCATACTGGGGGGTGGCGGGATGGAGGATGGGTACTCAG
GCATGACTGCGTATTTATTAAAGTGTGTTTTTCCACAATGTACCAAACAAGGCATAAGCAGCTTCTCCTGCTGACTGGCCAATCACTGCC
CATCTGAGAGATGATTTCCTCTGGCCCATATTTGAATTTATTGGAGTAACTCAAATTGCCTGAGGAAAAATGGAAAAATTATCCACCAGT
CGATTCAAACTGAATTTCACTCTTTATAGGAAGGCAGGGCAAACTTGTAGGAGTACGAAACATTTTCAATAAATCTACAAAGGGAAGCCT
TACTACAATTCCAAAAATCATCATGGTTGGAAATTTGGGAGGAGATTATTTGTGAACTTGTTACCCTTTTGGTAATGGTGGACTAATTGC
TGTATAGTTATTTTTGTTTTATTATTACTGTTACATTAATTTAACATGCATTTATAGAAGAATACATTCAAAGCACTGATGTAGGAGATA
CACGGTACTTGGAGCAGTCAGCCAGAAATCACAGATACTGCTTTCACTTAAATGGAAACAATTCTCCGATAATGCTTTGCTTTTTTTCTT
ATGTCACTCTTGTGTACTATCTATTTTTCTCCTCTCTGGGACCAAGTTTCTTTTTATAAAGCAATAATATCTCTGTTTTCATTTCAGAAC
ATTGTGCTGTCTGTCAGCATATGTATATCAGCTACAAAATATATTCAACTTTGACTTCTTTTGACAAAGGACTTTAGGAAAAAGAGGAAC
AAAGACATTATTTGAGAATTAAATTATATATTTTTAATATGACTGTGACCTTGACTGATAATAAAGATGTAATAAGAATTGCAAGCTAAA

>40852_40852_1_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000381652_DOCK8_chr9_286461_ENST00000453981_length(amino acids)=2399AA_BP=352
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLPQFYDPVE
PVDFEGLLMTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGS
RKDFHKTLPKQTFESETLECSEPAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFA
LYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQAR
SAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLERE
VTDVDSVVGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRL
EISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPV
IFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVAL
EKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICL
NSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGA
PTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHF
HEELALQMVVSTGMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSEIAALLVKPQKENEQAEKMNI
SLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPTLISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQD
QKIASMFDLTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLVGIILDALPQLC
DFTVADTRRYRTSGSDEEQEGAGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLP
STQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHWRQANE
KLDKTKAELDQEALISGNLATEAHLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEE
VEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMT
PFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLE
DHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTL
THSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNK
AYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPIEVAIE
DMKKKTLQLAVAINQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQR

--------------------------------------------------------------
>40852_40852_2_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000539801_DOCK8_chr9_286461_ENST00000453981_length(transcript)=8349nt_BP=1169nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGC
CTCAGTTTTATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCTGAACAGCCTGGATGTGCAGCTTGCCCAGGAGC
TCGGGGACTTCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGACTTTGCAGCCCTCTTTGCCGGAGGAAGGGGTTG
AACTGGACCCTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGTGAACCGGAAAAACCAAGGAAGTCCAGAAATCT
GTGGCTTTAAAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGACGTTTGAGTCGGAAACCTTGGAGTGCAGTGAAC
CCGCTGCTCAGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGGCCCCGTCACTGCCTGTGACTTTGACCTCCGCA
GCCTGCAGCCTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTTTGAGAAGCAGAACGAGGAGGCCCGGAGGACCA
ATAGGCAGGCCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGAAATACGTCCAGTACCAGAATGTCCCAAGGAAC
ACCTGGGCAACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGAGCCCCTGTTTGCCAGCATTGCCCTCTACGATG
TTAAAGAAAGGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTTCAAAGGATTTCTGCGAGCTCACACGCCTTCAG
TGGCCGCATCAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGACATCTACCTGGTAGTCAAGATTGAAAAAGTCC
TGCAGCAGGGAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGATGGTGGAAAGAGTAAAGAAAAGATTGAAAAAC
TAAAACTCCAAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGCCTGGGCACCCATAAGCTTATCAAGCTTCTTCA
ATGTCTCCACCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTCAGTGGGTGAACGGAGGACATTGGCCCAATCTA
GAAGGCTTTCTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAAAACCTCCACTCTGAGCGTTAGCAGCTTTTTCA
AGCAGGAAGGAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAAAAGATCATCATCCTTACAGAGACGAGTCAAGT
CAATTCCAGGCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTGTCTGACTCCTGAAATGCTGCCCGTGAAACCCT
TTCCTGAAAACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGTATATGTCCCTCACACTGTGTACAGAAACCTTC
TCTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAG
ATGCTAGCAATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACACAGCTGTTACATACCATAATA
AGTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCACCTCCTGTTCACCTTCTACCATATCA
GCTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTCTTAAATGAACGTCTTCAAACTGGAT
CCTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCCCATTACAGAATCCTCCCATTA
AGTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGGACAACCACCTGGAGAAGTTCT
TCACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCGAGATGGCGCTGGAGCATGAGC
TGAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGCTGGACAAGCTCTTCCAGCTGT
CCGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGGCCATCGCCAACAGTCTGCACA
ACAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCTTCCGCCTGCCAGAGGTGCAAA
GGGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCACATCAGCTGCTGCTGTGAGTT
CAAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAGACGAGGAAGTGAAGAACATCA
TGTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTCCAAGTTCACCTGCAGCCCCAA
GGCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGAGAGAAACAGTCTTCAAGTATG
CCTGGTTCTTCTTTGAGCTTCTGGTGAAAAGCATGGCCCAGCACGTACATAACATGGACAAACGGGACAGTTTTCGGAGGACTCGTTTTT
CTGACCGTTTCATGGATGACATAACTACTATTGTTAATGTGGTCACCTCGGAAATTGCAGCCCTTTTAGTAAAACCACAGAAGGAAAATG
AACAGGCGGAAAAGATGAACATCAGCCTGGCTTTCTTCTTGTATGACCTTCTCTCCCTCATGGATCGGGGCTTTGTGTTTAACCTCATCA
GACATTATTGCAGCCAGCTGTCAGCCAAGCTCAGTAACCTTCCAACGCTCATTTCCATGAGGCTAGAGTTCCTGAGAATCCTCTGTAGCC
ATGAGCATTACCTCAATCTGAACCTTTTTTTTATGAATGCTGATACTGCTCCAACATCTCCTTGTCCTTCCATATCTTCCCAGAACTCAA
GCTCCTGCTCCAGCTTCCAGGACCAGAAGATCGCCAGCATGTTCGATCTGACTTCCGAGTACCGCCAGCAGCACTTCCTCACCGGGCTCC
TCTTCACAGAACTGGCTGCTGCCCTGGATGCCGAAGGGGAAGGAATCAGCAAAGTACAAAGGAAAGCTGTCAGTGCAATTCACAGCCTGC
TAAGTTCTCACGACCTGGACCCACGCTGTGTCAAACCAGAGGTGAAGGTCAAAATCGCCGCCCTTTACCTACCTTTAGTTGGCATCATTT
TGGATGCTTTGCCACAGCTCTGTGACTTTACAGTTGCAGATACTCGCAGATACCGCACCAGTGGCTCGGATGAAGAACAAGAAGGAGCCG
GTGCCATTAACCAGAATGTGGCTCTGGCCATAGCAGGGAATAATTTCAATTTGAAAACAAGTGGAATAGTGCTGTCTTCCTTGCCCTATA
AGCAGTACAACATGCTGAACGCGGACACTACTCGCAACCTCATGATCTGCTTCCTCTGGATCATGAAAAATGCTGATCAGAGCCTCATTA
GGAAGTGGATTGCTGACCTGCCATCAACGCAGCTCAACAGGATTTTAGATCTACTTTTCATCTGTGTGTTATGTTTTGAGTATAAGGGAA
AACAGAGTTCTGACAAAGTCAGTACCCAAGTCCTGCAGAAGTCAAGGGATGTCAAGGCCCGGCTGGAAGAGGCTTTGCTCCGTGGGGAAG
GGGCCAGAGGGGAGATGATGCGCCGCCGGGCTCCAGGGAACGACCGATTTCCAGGCCTAAATGAAAATTTGAGATGGAAGAAAGAGCAGA
CACATTGGCGGCAAGCTAATGAGAAGCTAGATAAAACAAAGGCCGAGTTAGATCAAGAAGCCTTGATCAGTGGCAATCTGGCTACAGAAG
CACATTTAATCATCCTGGATATGCAGGAAAACATTATCCAGGCGAGCTCGGCTCTGGACTGTAAAGACAGCCTGCTGGGAGGTGTTCTGA
GGGTGCTGGTGAATTCTCTGAACTGTGATCAGAGTACCACCTACCTGACTCACTGCTTTGCAACACTCCGTGCTCTCATCGCCAAGTTTG
GAGACTTACTCTTTGAAGAGGAGGTGGAACAGTGTTTCGACCTATGTCACCAAGTCCTGCACCACTGCAGCAGCAGCATGGATGTCACCC
GGAGCCAAGCCTGTGCCACCCTTTACCTCCTCATGAGGTTCAGTTTTGGAGCCACCAGTAATTTTGCAAGAGTAAAGATGCAAGTAACCA
TGTCCCTGGCATCTTTGGTGGGAAGAGCACCAGACTTTAATGAAGAGCACCTGAGAAGATCCTTGAGGACAATTTTGGCCTATTCAGAAG
AGGACACAGCCATGCAGATGACTCCTTTTCCCACCCAGGTGGAGGAACTTCTCTGTAATCTGAATAGCATCTTATATGACACAGTGAAAA
TGAGGGAATTTCAGGAAGATCCTGAGATGCTTATGGATCTCATGTACAGAATTGCCAAGAGTTACCAGGCATCTCCTGATCTGCGGCTGA
CCTGGCTCCAGAACATGGCAGAGAAACACACCAAGAAGAAGTGCTACACGGAGGCTGCCATGTGCCTGGTGCACGCCGCTGCGTTAGTGG
CTGAGTATCTGAGCATGCTGGAGGACCACAGCTACCTGCCCGTGGGCAGTGTCAGCTTCCAGAATATTTCTTCCAATGTGCTGGAGGAGT
CTGTGGTCTCTGAGGACACCCTGTCACCTGACGAGGATGGGGTGTGCGCAGGCCAGTACTTCACCGAGAGTGGCCTGGTAGGCCTCCTGG
AGCAGGCCGCGGAGCTCTTCAGCACGGGAGGCTTATATGAGACAGTTAATGAGGTCTACAAGCTGGTCATCCCCATCCTAGAAGCGCATC
GAGAATTCCGGAAGCTGACACTCACTCACAGCAAGCTGCAGAGAGCCTTCGACAGCATCGTTAACAAGGATCATAAGAGAATGTTTGGAA
CCTACTTCCGAGTTGGTTTCTTTGGATCCAAATTTGGGGATTTGGATGAACAGGAGTTTGTCTACAAAGAGCCTGCAATTACCAAGCTTC
CTGAGATCTCACATAGACTAGAGGCATTTTATGGTCAATGTTTTGGTGCAGAATTTGTGGAAGTGATTAAAGACTCCACTCCTGTGGACA
AAACCAAGTTGGATCCTAACAAGGCCTACATACAGATCACTTTTGTGGAGCCCTACTTTGATGAGTATGAGATGAAAGACAGGGTCACAT
ACTTTGAGAAGAATTTCAACCTCCGGAGGTTCATGTACACCACCCCGTTCACCCTGGAGGGGCGGCCTCGGGGAGAGCTGCATGAGCAGT
ACAGAAGGAACACAGTCCTGACCACTATGCACGCCTTCCCCTACATCAAGACCAGGATCAGCGTCATCCAGAAGGAGGAGTTTGTTTTGA
CACCGATTGAAGTTGCCATTGAAGACATGAAGAAGAAGACCCTGCAGTTAGCAGTTGCCATTAACCAGGAGCCGCCTGATGCAAAGATGC
TTCAGATGGTGCTGCAAGGCTCTGTGGGAGCTACTGTAAATCAGGGACCACTGGAAGTAGCCCAAGTGTTTTTGGCTGAAATTCCTGCTG
ATCCAAAACTCTATCGACATCACAACAAGTTGAGGTTATGCTTTAAGGAATTCATCATGAGATGTGGTGAAGCTGTAGAGAAAAACAAGC
GTCTCATCACGGCAGACCAGAGGGAATATCAGCAGGAACTCAAAAAGAACTATAACAAGCTAAAAGAGAACCTCAGGCCAATGATCGAGC
GGAAAATTCCAGAACTGTACAAGCCAATATTCAGAGTTGAGAGTCAAAAGAGGGACTCCTTCCACAGATCTAGTTTCAGGAAATGTGAAA
CCCAGTTGTCACAGGGCAGCTAAGAAAAGCCATCTTCATTCGTGGAGACTGTGGCCCTGCAACCCTGGAGAAGGACTTGCTGGTACTTAA
AAAATGGGACATTTGCCACCCAGGACTGACTGTACACTCCCTGATCAGCCAGCACTCTGGAAGCTTTGGGATCCCAGGAACCATGGAATT
ATTCCCAAATGGACTCTGACCAGATTTTTGCCATACTGGGGGGTGGCGGGATGGAGGATGGGTACTCAGGCATGACTGCGTATTTATTAA
AGTGTGTTTTTCCACAATGTACCAAACAAGGCATAAGCAGCTTCTCCTGCTGACTGGCCAATCACTGCCCATCTGAGAGATGATTTCCTC
TGGCCCATATTTGAATTTATTGGAGTAACTCAAATTGCCTGAGGAAAAATGGAAAAATTATCCACCAGTCGATTCAAACTGAATTTCACT
CTTTATAGGAAGGCAGGGCAAACTTGTAGGAGTACGAAACATTTTCAATAAATCTACAAAGGGAAGCCTTACTACAATTCCAAAAATCAT
CATGGTTGGAAATTTGGGAGGAGATTATTTGTGAACTTGTTACCCTTTTGGTAATGGTGGACTAATTGCTGTATAGTTATTTTTGTTTTA
TTATTACTGTTACATTAATTTAACATGCATTTATAGAAGAATACATTCAAAGCACTGATGTAGGAGATACACGGTACTTGGAGCAGTCAG
CCAGAAATCACAGATACTGCTTTCACTTAAATGGAAACAATTCTCCGATAATGCTTTGCTTTTTTTCTTATGTCACTCTTGTGTACTATC
TATTTTTCTCCTCTCTGGGACCAAGTTTCTTTTTATAAAGCAATAATATCTCTGTTTTCATTTCAGAACATTGTGCTGTCTGTCAGCATA
TGTATATCAGCTACAAAATATATTCAACTTTGACTTCTTTTGACAAAGGACTTTAGGAAAAAGAGGAACAAAGACATTATTTGAGAATTA

>40852_40852_2_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000539801_DOCK8_chr9_286461_ENST00000453981_length(amino acids)=2399AA_BP=352
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLPQFYDPVE
PVDFEGLLMTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGS
RKDFHKTLPKQTFESETLECSEPAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFA
LYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQAR
SAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLERE
VTDVDSVVGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRL
EISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPV
IFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVAL
EKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICL
NSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGA
PTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHF
HEELALQMVVSTGMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSEIAALLVKPQKENEQAEKMNI
SLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPTLISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQD
QKIASMFDLTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLVGIILDALPQLC
DFTVADTRRYRTSGSDEEQEGAGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLP
STQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHWRQANE
KLDKTKAELDQEALISGNLATEAHLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEE
VEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMT
PFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLE
DHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTL
THSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNK
AYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPIEVAIE
DMKKKTLQLAVAINQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQR

--------------------------------------------------------------
>40852_40852_3_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000544510_DOCK8_chr9_286461_ENST00000453981_length(transcript)=8160nt_BP=980nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGCCTCAGTTTT
ATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCTGAACAGCCTGGATGTGCAGCTTGCCCAGGAGCTCGGGGACT
TCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGACTTTGCAGCCCTCTTTGCCGGAGGAAGGGGTTGAACTGGACC
CTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGTGAACCGGAAAAACCAAGGAAGTCCAGAAATCTGTGGCTTTA
AAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGACGTTTGAGTCGGAAACCTTGGAGTGCAGTGAACCCGCTGCTC
AGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGGCCCCGTCACTGCCTGTGACTTTGACCTCCGCAGCCTGCAGC
CTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTTTGAGAAGCAGAACGAGGAGGCCCGGAGGACCAATAGGCAGG
CCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGAAATACGTCCAGTACCAGAATGTCCCAAGGAACACCTGGGCA
ACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGAGCCCCTGTTTGCCAGCATTGCCCTCTACGATGTTAAAGAAA
GGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTTCAAAGGATTTCTGCGAGCTCACACGCCTTCAGTGGCCGCAT
CAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGACATCTACCTGGTAGTCAAGATTGAAAAAGTCCTGCAGCAGG
GAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGATGGTGGAAAGAGTAAAGAAAAGATTGAAAAACTAAAACTCC
AAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGCCTGGGCACCCATAAGCTTATCAAGCTTCTTCAATGTCTCCA
CCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTCAGTGGGTGAACGGAGGACATTGGCCCAATCTAGAAGGCTTT
CTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAAAACCTCCACTCTGAGCGTTAGCAGCTTTTTCAAGCAGGAAG
GAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAAAAGATCATCATCCTTACAGAGACGAGTCAAGTCAATTCCAG
GCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTGTCTGACTCCTGAAATGCTGCCCGTGAAACCCTTTCCTGAAA
ACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGTATATGTCCCTCACACTGTGTACAGAAACCTTCTCTATGTCT
ACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAGATGCTAGCA
ATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACACAGCTGTTACATACCATAATAAGTCTCCTG
ACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCACCTCCTGTTCACCTTCTACCATATCAGCTGTCAGC
AGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTCTTAAATGAACGTCTTCAAACTGGATCCTACTGTC
TCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCCCATTACAGAATCCTCCCATTAAGTGGGCTG
AAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGGACAACCACCTGGAGAAGTTCTTCACCCTCT
GCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCGAGATGGCGCTGGAGCATGAGCTGAAGCTCA
GCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGCTGGACAAGCTCTTCCAGCTGTCCGTGCAGC
CCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGGCCATCGCCAACAGTCTGCACAACAGCAAGG
ACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCTTCCGCCTGCCAGAGGTGCAAAGGGATGTGC
CCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCACATCAGCTGCTGCTGTGAGTTCAAAGCTGC
TGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAGACGAGGAAGTGAAGAACATCATGTCTTCAA
AGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTCCAAGTTCACCTGCAGCCCCAAGGCCAGCCA
GCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGAGAGAAACAGTCTTCAAGTATGCCTGGTTCT
TCTTTGAGCTTCTGGTGAAAAGCATGGCCCAGCACGTACATAACATGGACAAACGGGACAGTTTTCGGAGGACTCGTTTTTCTGACCGTT
TCATGGATGACATAACTACTATTGTTAATGTGGTCACCTCGGAAATTGCAGCCCTTTTAGTAAAACCACAGAAGGAAAATGAACAGGCGG
AAAAGATGAACATCAGCCTGGCTTTCTTCTTGTATGACCTTCTCTCCCTCATGGATCGGGGCTTTGTGTTTAACCTCATCAGACATTATT
GCAGCCAGCTGTCAGCCAAGCTCAGTAACCTTCCAACGCTCATTTCCATGAGGCTAGAGTTCCTGAGAATCCTCTGTAGCCATGAGCATT
ACCTCAATCTGAACCTTTTTTTTATGAATGCTGATACTGCTCCAACATCTCCTTGTCCTTCCATATCTTCCCAGAACTCAAGCTCCTGCT
CCAGCTTCCAGGACCAGAAGATCGCCAGCATGTTCGATCTGACTTCCGAGTACCGCCAGCAGCACTTCCTCACCGGGCTCCTCTTCACAG
AACTGGCTGCTGCCCTGGATGCCGAAGGGGAAGGAATCAGCAAAGTACAAAGGAAAGCTGTCAGTGCAATTCACAGCCTGCTAAGTTCTC
ACGACCTGGACCCACGCTGTGTCAAACCAGAGGTGAAGGTCAAAATCGCCGCCCTTTACCTACCTTTAGTTGGCATCATTTTGGATGCTT
TGCCACAGCTCTGTGACTTTACAGTTGCAGATACTCGCAGATACCGCACCAGTGGCTCGGATGAAGAACAAGAAGGAGCCGGTGCCATTA
ACCAGAATGTGGCTCTGGCCATAGCAGGGAATAATTTCAATTTGAAAACAAGTGGAATAGTGCTGTCTTCCTTGCCCTATAAGCAGTACA
ACATGCTGAACGCGGACACTACTCGCAACCTCATGATCTGCTTCCTCTGGATCATGAAAAATGCTGATCAGAGCCTCATTAGGAAGTGGA
TTGCTGACCTGCCATCAACGCAGCTCAACAGGATTTTAGATCTACTTTTCATCTGTGTGTTATGTTTTGAGTATAAGGGAAAACAGAGTT
CTGACAAAGTCAGTACCCAAGTCCTGCAGAAGTCAAGGGATGTCAAGGCCCGGCTGGAAGAGGCTTTGCTCCGTGGGGAAGGGGCCAGAG
GGGAGATGATGCGCCGCCGGGCTCCAGGGAACGACCGATTTCCAGGCCTAAATGAAAATTTGAGATGGAAGAAAGAGCAGACACATTGGC
GGCAAGCTAATGAGAAGCTAGATAAAACAAAGGCCGAGTTAGATCAAGAAGCCTTGATCAGTGGCAATCTGGCTACAGAAGCACATTTAA
TCATCCTGGATATGCAGGAAAACATTATCCAGGCGAGCTCGGCTCTGGACTGTAAAGACAGCCTGCTGGGAGGTGTTCTGAGGGTGCTGG
TGAATTCTCTGAACTGTGATCAGAGTACCACCTACCTGACTCACTGCTTTGCAACACTCCGTGCTCTCATCGCCAAGTTTGGAGACTTAC
TCTTTGAAGAGGAGGTGGAACAGTGTTTCGACCTATGTCACCAAGTCCTGCACCACTGCAGCAGCAGCATGGATGTCACCCGGAGCCAAG
CCTGTGCCACCCTTTACCTCCTCATGAGGTTCAGTTTTGGAGCCACCAGTAATTTTGCAAGAGTAAAGATGCAAGTAACCATGTCCCTGG
CATCTTTGGTGGGAAGAGCACCAGACTTTAATGAAGAGCACCTGAGAAGATCCTTGAGGACAATTTTGGCCTATTCAGAAGAGGACACAG
CCATGCAGATGACTCCTTTTCCCACCCAGGTGGAGGAACTTCTCTGTAATCTGAATAGCATCTTATATGACACAGTGAAAATGAGGGAAT
TTCAGGAAGATCCTGAGATGCTTATGGATCTCATGTACAGAATTGCCAAGAGTTACCAGGCATCTCCTGATCTGCGGCTGACCTGGCTCC
AGAACATGGCAGAGAAACACACCAAGAAGAAGTGCTACACGGAGGCTGCCATGTGCCTGGTGCACGCCGCTGCGTTAGTGGCTGAGTATC
TGAGCATGCTGGAGGACCACAGCTACCTGCCCGTGGGCAGTGTCAGCTTCCAGAATATTTCTTCCAATGTGCTGGAGGAGTCTGTGGTCT
CTGAGGACACCCTGTCACCTGACGAGGATGGGGTGTGCGCAGGCCAGTACTTCACCGAGAGTGGCCTGGTAGGCCTCCTGGAGCAGGCCG
CGGAGCTCTTCAGCACGGGAGGCTTATATGAGACAGTTAATGAGGTCTACAAGCTGGTCATCCCCATCCTAGAAGCGCATCGAGAATTCC
GGAAGCTGACACTCACTCACAGCAAGCTGCAGAGAGCCTTCGACAGCATCGTTAACAAGGATCATAAGAGAATGTTTGGAACCTACTTCC
GAGTTGGTTTCTTTGGATCCAAATTTGGGGATTTGGATGAACAGGAGTTTGTCTACAAAGAGCCTGCAATTACCAAGCTTCCTGAGATCT
CACATAGACTAGAGGCATTTTATGGTCAATGTTTTGGTGCAGAATTTGTGGAAGTGATTAAAGACTCCACTCCTGTGGACAAAACCAAGT
TGGATCCTAACAAGGCCTACATACAGATCACTTTTGTGGAGCCCTACTTTGATGAGTATGAGATGAAAGACAGGGTCACATACTTTGAGA
AGAATTTCAACCTCCGGAGGTTCATGTACACCACCCCGTTCACCCTGGAGGGGCGGCCTCGGGGAGAGCTGCATGAGCAGTACAGAAGGA
ACACAGTCCTGACCACTATGCACGCCTTCCCCTACATCAAGACCAGGATCAGCGTCATCCAGAAGGAGGAGTTTGTTTTGACACCGATTG
AAGTTGCCATTGAAGACATGAAGAAGAAGACCCTGCAGTTAGCAGTTGCCATTAACCAGGAGCCGCCTGATGCAAAGATGCTTCAGATGG
TGCTGCAAGGCTCTGTGGGAGCTACTGTAAATCAGGGACCACTGGAAGTAGCCCAAGTGTTTTTGGCTGAAATTCCTGCTGATCCAAAAC
TCTATCGACATCACAACAAGTTGAGGTTATGCTTTAAGGAATTCATCATGAGATGTGGTGAAGCTGTAGAGAAAAACAAGCGTCTCATCA
CGGCAGACCAGAGGGAATATCAGCAGGAACTCAAAAAGAACTATAACAAGCTAAAAGAGAACCTCAGGCCAATGATCGAGCGGAAAATTC
CAGAACTGTACAAGCCAATATTCAGAGTTGAGAGTCAAAAGAGGGACTCCTTCCACAGATCTAGTTTCAGGAAATGTGAAACCCAGTTGT
CACAGGGCAGCTAAGAAAAGCCATCTTCATTCGTGGAGACTGTGGCCCTGCAACCCTGGAGAAGGACTTGCTGGTACTTAAAAAATGGGA
CATTTGCCACCCAGGACTGACTGTACACTCCCTGATCAGCCAGCACTCTGGAAGCTTTGGGATCCCAGGAACCATGGAATTATTCCCAAA
TGGACTCTGACCAGATTTTTGCCATACTGGGGGGTGGCGGGATGGAGGATGGGTACTCAGGCATGACTGCGTATTTATTAAAGTGTGTTT
TTCCACAATGTACCAAACAAGGCATAAGCAGCTTCTCCTGCTGACTGGCCAATCACTGCCCATCTGAGAGATGATTTCCTCTGGCCCATA
TTTGAATTTATTGGAGTAACTCAAATTGCCTGAGGAAAAATGGAAAAATTATCCACCAGTCGATTCAAACTGAATTTCACTCTTTATAGG
AAGGCAGGGCAAACTTGTAGGAGTACGAAACATTTTCAATAAATCTACAAAGGGAAGCCTTACTACAATTCCAAAAATCATCATGGTTGG
AAATTTGGGAGGAGATTATTTGTGAACTTGTTACCCTTTTGGTAATGGTGGACTAATTGCTGTATAGTTATTTTTGTTTTATTATTACTG
TTACATTAATTTAACATGCATTTATAGAAGAATACATTCAAAGCACTGATGTAGGAGATACACGGTACTTGGAGCAGTCAGCCAGAAATC
ACAGATACTGCTTTCACTTAAATGGAAACAATTCTCCGATAATGCTTTGCTTTTTTTCTTATGTCACTCTTGTGTACTATCTATTTTTCT
CCTCTCTGGGACCAAGTTTCTTTTTATAAAGCAATAATATCTCTGTTTTCATTTCAGAACATTGTGCTGTCTGTCAGCATATGTATATCA
GCTACAAAATATATTCAACTTTGACTTCTTTTGACAAAGGACTTTAGGAAAAAGAGGAACAAAGACATTATTTGAGAATTAAATTATATA

>40852_40852_3_JAK2-DOCK8_JAK2_chr9_5055788_ENST00000544510_DOCK8_chr9_286461_ENST00000453981_length(amino acids)=2287AA_BP=240
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLPQFYDPVEPVDFEGLLMTHLNSLDVQLAQE
LGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSE
PAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDEEDAVEIRPVPECPKE
HLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKV
LQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGERRTLAQS
RRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKP
FPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHN
KSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPI
KWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQL
SVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVS
SKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKY
AWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSEIAALLVKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLI
RHYCSQLSAKLSNLPTLISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASMFDLTSEYRQQHFLTGL
LFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLVGIILDALPQLCDFTVADTRRYRTSGSDEEQEGA
GAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLPSTQLNRILDLLFICVLCFEYKG
KQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATE
AHLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLCHQVLHHCSSSMDVT
RSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLNSILYDTVK
MREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEE
SVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVNKDHKRMFG
TYFRVGFFGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVT
YFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPIEVAIEDMKKKTLQLAVAINQEPPDAKM
LQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQREYQQELKKNYNKLKENLRPMIE

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Fusion Gene PPI Analysis for JAK2-DOCK8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneJAK2chr9:5055788chr9:286461ENST00000381652+8251_239352.01133.0cytokine/interferon/growth hormone receptors
HgeneJAK2chr9:5055788chr9:286461ENST00000539801+7241_239352.01133.0cytokine/interferon/growth hormone receptors


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for JAK2-DOCK8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for JAK2-DOCK8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource