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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:JAK2-PCM1 (FusionGDB2 ID:40858)

Fusion Gene Summary for JAK2-PCM1

check button Fusion gene summary
Fusion gene informationFusion gene name: JAK2-PCM1
Fusion gene ID: 40858
HgeneTgene
Gene symbol

JAK2

PCM1

Gene ID

3717

5108

Gene nameJanus kinase 2pericentriolar material 1
SynonymsJTK10|THCYT3PTC4|RET/PCM-1
Cytomap

9p24.1

8p22

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1
Modification date2020032920200327
UniProtAcc.

Q15154

Ensembl transtripts involved in fusion geneENST00000381652, ENST00000539801, 
ENST00000544510, ENST00000487310, 
ENST00000327578, ENST00000518537, 
ENST00000518936, ENST00000524226, 
ENST00000325083, ENST00000519253, 
Fusion gene scores* DoF score13 X 10 X 8=104010 X 14 X 6=840
# samples 1113
** MAII scorelog2(11/1040*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/840*10)=-2.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JAK2 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
JAK2-PCM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
JAK2-PCM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJAK2

GO:0010811

positive regulation of cell-substrate adhesion

10925297

HgeneJAK2

GO:0019221

cytokine-mediated signaling pathway

8609418

HgeneJAK2

GO:0033209

tumor necrosis factor-mediated signaling pathway

8609418

HgeneJAK2

GO:0034612

response to tumor necrosis factor

8609418

HgeneJAK2

GO:0035409

histone H3-Y41 phosphorylation

19783980

HgeneJAK2

GO:0035722

interleukin-12-mediated signaling pathway

7528775

HgeneJAK2

GO:0046677

response to antibiotic

16280321

HgeneJAK2

GO:0050727

regulation of inflammatory response

10925297

HgeneJAK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgeneJAK2

GO:0070671

response to interleukin-12

7528775


check buttonFusion gene breakpoints across JAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PCM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..JAK2chr9

5066789

+PCM1chr8

17829837

+
ChimerKB3..JAK2chr9

5066789

+PCM1chr8

17882869

+
ChimerKB3..JAK2chr9

5069208

+PCM1chr8

17842955

+
ChimerKB3..JAK2chr9

5069208

+PCM1chr8

17871472

+


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Fusion Gene ORF analysis for JAK2-PCM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381652ENST00000327578JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000381652ENST00000327578JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000381652ENST00000327578JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000381652ENST00000327578JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000381652ENST00000518537JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000381652ENST00000518537JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000381652ENST00000518537JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000381652ENST00000518537JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000381652ENST00000518936JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000381652ENST00000518936JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000381652ENST00000518936JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000381652ENST00000518936JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000381652ENST00000524226JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000539801ENST00000327578JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000539801ENST00000327578JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000539801ENST00000327578JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000539801ENST00000327578JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000539801ENST00000518537JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000539801ENST00000518537JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000539801ENST00000518537JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000539801ENST00000518537JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000539801ENST00000518936JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000539801ENST00000518936JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000539801ENST00000518936JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000539801ENST00000518936JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000539801ENST00000524226JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000544510ENST00000327578JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000544510ENST00000327578JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000544510ENST00000327578JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000544510ENST00000327578JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000544510ENST00000518537JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000544510ENST00000518537JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000544510ENST00000518537JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000544510ENST00000518537JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000544510ENST00000518936JAK2chr9

5066789

+PCM1chr8

17829837

+
5CDS-intronENST00000544510ENST00000518936JAK2chr9

5066789

+PCM1chr8

17882869

+
5CDS-intronENST00000544510ENST00000518936JAK2chr9

5069208

+PCM1chr8

17842955

+
5CDS-intronENST00000544510ENST00000518936JAK2chr9

5069208

+PCM1chr8

17871472

+
5CDS-intronENST00000544510ENST00000524226JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000381652ENST00000325083JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000381652ENST00000325083JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000381652ENST00000519253JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000381652ENST00000519253JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000381652ENST00000524226JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000539801ENST00000325083JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000539801ENST00000325083JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000539801ENST00000519253JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000539801ENST00000519253JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000539801ENST00000524226JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000544510ENST00000325083JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000544510ENST00000325083JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000544510ENST00000519253JAK2chr9

5066789

+PCM1chr8

17829837

+
Frame-shiftENST00000544510ENST00000519253JAK2chr9

5069208

+PCM1chr8

17871472

+
Frame-shiftENST00000544510ENST00000524226JAK2chr9

5066789

+PCM1chr8

17829837

+
In-frameENST00000381652ENST00000325083JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000381652ENST00000325083JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000381652ENST00000519253JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000381652ENST00000519253JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000381652ENST00000524226JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000381652ENST00000524226JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000539801ENST00000325083JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000539801ENST00000325083JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000539801ENST00000519253JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000539801ENST00000519253JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000539801ENST00000524226JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000539801ENST00000524226JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000544510ENST00000325083JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000544510ENST00000325083JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000544510ENST00000519253JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000544510ENST00000519253JAK2chr9

5069208

+PCM1chr8

17842955

+
In-frameENST00000544510ENST00000524226JAK2chr9

5066789

+PCM1chr8

17882869

+
In-frameENST00000544510ENST00000524226JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-3CDSENST00000487310ENST00000325083JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-3CDSENST00000487310ENST00000325083JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-3CDSENST00000487310ENST00000325083JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-3CDSENST00000487310ENST00000325083JAK2chr9

5069208

+PCM1chr8

17871472

+
intron-3CDSENST00000487310ENST00000519253JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-3CDSENST00000487310ENST00000519253JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-3CDSENST00000487310ENST00000519253JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-3CDSENST00000487310ENST00000519253JAK2chr9

5069208

+PCM1chr8

17871472

+
intron-3CDSENST00000487310ENST00000524226JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-3CDSENST00000487310ENST00000524226JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-3CDSENST00000487310ENST00000524226JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-intronENST00000487310ENST00000327578JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-intronENST00000487310ENST00000327578JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-intronENST00000487310ENST00000327578JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-intronENST00000487310ENST00000327578JAK2chr9

5069208

+PCM1chr8

17871472

+
intron-intronENST00000487310ENST00000518537JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-intronENST00000487310ENST00000518537JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-intronENST00000487310ENST00000518537JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-intronENST00000487310ENST00000518537JAK2chr9

5069208

+PCM1chr8

17871472

+
intron-intronENST00000487310ENST00000518936JAK2chr9

5066789

+PCM1chr8

17829837

+
intron-intronENST00000487310ENST00000518936JAK2chr9

5066789

+PCM1chr8

17882869

+
intron-intronENST00000487310ENST00000518936JAK2chr9

5069208

+PCM1chr8

17842955

+
intron-intronENST00000487310ENST00000518936JAK2chr9

5069208

+PCM1chr8

17871472

+
intron-intronENST00000487310ENST00000524226JAK2chr9

5069208

+PCM1chr8

17871472

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539801JAK2chr95066789+ENST00000325083PCM1chr817882869+197914391131672519
ENST00000539801JAK2chr95066789+ENST00000519253PCM1chr817882869+181414391131672519
ENST00000539801JAK2chr95066789+ENST00000524226PCM1chr817882869+198014391131672519
ENST00000381652JAK2chr95066789+ENST00000325083PCM1chr817882869+236018204942053519
ENST00000381652JAK2chr95066789+ENST00000519253PCM1chr817882869+219518204942053519
ENST00000381652JAK2chr95066789+ENST00000524226PCM1chr817882869+236118204942053519
ENST00000544510JAK2chr95066789+ENST00000325083PCM1chr817882869+179012502601483407
ENST00000544510JAK2chr95066789+ENST00000519253PCM1chr817882869+162512502601483407
ENST00000544510JAK2chr95066789+ENST00000524226PCM1chr817882869+179112502601483407
ENST00000539801JAK2chr95069208+ENST00000325083PCM1chr817842955+3899162611335921159
ENST00000539801JAK2chr95069208+ENST00000519253PCM1chr817842955+3710162611335681151
ENST00000539801JAK2chr95069208+ENST00000524226PCM1chr817842955+3570162611332621049
ENST00000381652JAK2chr95069208+ENST00000325083PCM1chr817842955+4280200749439731159
ENST00000381652JAK2chr95069208+ENST00000519253PCM1chr817842955+4091200749439491151
ENST00000381652JAK2chr95069208+ENST00000524226PCM1chr817842955+3951200749436431049
ENST00000544510JAK2chr95069208+ENST00000325083PCM1chr817842955+3710143726034031047
ENST00000544510JAK2chr95069208+ENST00000519253PCM1chr817842955+3521143726033791039
ENST00000544510JAK2chr95069208+ENST00000524226PCM1chr817842955+338114372603073937

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for JAK2-PCM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for JAK2-PCM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr8:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PCM1

Q15154

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for JAK2-PCM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40858_40858_1_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000325083_length(transcript)=2360nt_BP=1820nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCAC
TGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAA
TGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCT
CATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGAC
ACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACAC
TGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATGTTTGGTAACGAATTTAAAATGTAGTTTTAA

>40858_40858_1_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_2_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000519253_length(transcript)=2195nt_BP=1820nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCAC
TGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAA
TGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCT
CATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGAC

>40858_40858_2_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_3_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000524226_length(transcript)=2361nt_BP=1820nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCAC
TGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAA
TGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCT
CATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGAC
ACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACAC
TGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATGTTTGGTAACGAATTTAAAATGTAGTTTTAA

>40858_40858_3_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_4_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000325083_length(transcript)=1979nt_BP=1439nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGG
AAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAG
AGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTG
GAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACAT
ACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTG
GTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCC

>40858_40858_4_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_5_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000519253_length(transcript)=1814nt_BP=1439nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGG
AAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAG
AGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTG
GAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACAT
ACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTG

>40858_40858_5_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_6_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000524226_length(transcript)=1980nt_BP=1439nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGG
AAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAG
AGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTG
GAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACAT
ACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTG
GTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCC
CTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATGTTTGGTAACGAATTTAAAATGTAGTTTTAAATAAAGTTTGGACTTATCTAT

>40858_40858_6_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------
>40858_40858_7_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000325083_length(transcript)=1790nt_BP=1250nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGGAAGCAGAAT
CTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATC
TAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTG
AGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGC
ATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCT
CCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTT

>40858_40858_7_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------
>40858_40858_8_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000519253_length(transcript)=1625nt_BP=1250nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGGAAGCAGAAT
CTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATC
TAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTG
AGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGC
ATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCT

>40858_40858_8_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------
>40858_40858_9_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000524226_length(transcript)=1791nt_BP=1250nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGGAAGCAGAAT
CTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATC
TAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTG
AGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGC
ATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCT
CCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTT

>40858_40858_9_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------
>40858_40858_10_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000325083_length(transcript)=4280nt_BP=2007nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTG
GGACAAAGAAGAACTTCAGCAGTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTA
CTAAATGCTGTCCCCCAAAGCCAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTA
CATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGA
GGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTA
CTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAA
CCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAG
GTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGA
GATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATC
GTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTA
TGAAAGAAGTCATTCCTTTTTTGAAGGAGCACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCC
TTACCCAGCAAAATGATGAGAGCAAAGAGTTTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTG
CTGGCAGAAAACTGAAAGACTGTGGAGAAGATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGC
AAGATTTGGATAATAATAGTATAACTGTTAAACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGG
CTAAAAGGATTCTTGAAGATCATGGCTCACCTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGA
CTCAAACATCTGAGGTGTATGATGGTCCCAAAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAG
TGTCTATTAATTTGTCTAAAGCTGAAACTCAGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAAT
TTGAAGAAGGCCCTGTGGATGTCCAGACTTCCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGTCCTACAAC
GTGACTTTAAAAAGACAGCAGAAAGCAAAAATGTCCCATTGGAACGAGAAGCCACTAGTAAAAATGACCAAAATAACTGTCCTGTGAAAC
CCTGTTACCTCAATATCTTGGAAGATGAGCAACCTTTAAATAGTGCTGCCCATAAGGAGTCACCTCCTACTGTTGATTCAACTCAACAGC
CTAACCCTTTGCCGTTACGTTTACCTGAAATGGAACCCTTAGTGCCTAGAGTCAAAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCT
CTCTGGCTGGAAGTCCTGATACTGAATCTCCAGTGTTAGTGAATGACTATGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAG
AAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGA
AAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAG
CCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCT
GATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTG
AATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATG

>40858_40858_10_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1159AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE
REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVN

--------------------------------------------------------------
>40858_40858_11_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000519253_length(transcript)=4091nt_BP=2007nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTG
GGACAAAGAAGAACTTCAGCAGTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTA
CTAAATGCTGTCCCCCAAAGCCAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTA
CATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGA
GGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTA
CTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAA
CCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAG
GTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGA
GATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTG
AAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGA
AGGAGCACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGAGCA
AAGAGTTTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACTGTG
GAGAAGATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTATAA
CTGTTAAACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATCATG
GCTCACCTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATGATG
GTCCCAAAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAGCTG
AAACTCAGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATGTCC
AGACTTCCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGTCCTACAACGTGACTTTAAAAAGACAGCAGAAA
GCAAAAATGTCCCATTGGAACGAGAAGCCACTAGTAAAAATGACCAAAATAACTGTCCTGTGAAACCCTGTTACCTCAATATCTTGGAAG
ATGAGCAACCTTTAAATAGTGCTGCCCATAAGGAGTCACCTCCTACTGTTGATTCAACTCAACAGCCTAACCCTTTGCCGTTACGTTTAC
CTGAAATGGAACCCTTAGTGCCTAGAGTCAAAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCTCTCTGGCTGGAAGTCCTGATACTG
AATCTCCAGTGTTAGTGAATGACTATGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATT
TACCACTGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATAT
GTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCA
GAGGCTCATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAG

>40858_40858_11_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1151AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQL
DRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNE
LAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED
EESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKND
QNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGN

--------------------------------------------------------------
>40858_40858_12_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000524226_length(transcript)=3951nt_BP=2007nt
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCCTCCCTCGGCGCTGACAGGCTGGGCCGGCGC
CCGGCTCGCTTGGGTGTTCGCGTCGCCACTTCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGAGCCCACACTGGAGGGCCCCCGAGGGCCCAG
CCTGGAGGTCGTTCAGAGCCGTGCCCGTCCCGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAACTGTTTCTCTTCTGCAGAAAAAGAGGCTCT
TCCTCCTCCTCCCGCGACGGCAAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATT
CCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATG
AGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGA
TAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAA
GGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTG
CAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATA
AGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGA
TGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTG
GGACAAAGAAGAACTTCAGCAGTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTA
CTAAATGCTGTCCCCCAAAGCCAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTA
CATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGA
GGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTA
CTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAA
CCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAG
GTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGA
GATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATC
GTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTA
TGAAAGAAGTCATTCCTTTTTTGAAGGAGCACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCC
TTACCCAGCAAAATGATGAGAGCAAAGAGTTTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTG
CTGGCAGAAAACTGAAAGACTGTGGAGAAGATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGC
AAGATTTGGATAATAATAGTATAACTGTTAAACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGG
CTAAAAGGATTCTTGAAGATCATGGCTCACCTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGA
CTCAAACATCTGAGGTGTATGATGGTCCCAAAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAG
TGTCTATTAATTTGTCTAAAGCTGAAACTCAGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAAT
TTGAAGAAGGCCCTGTGGATGTCCAGACTTCCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGAAGCAGAAT
CTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATC
TAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTG
AGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGC
ATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCT
CCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTT

>40858_40858_12_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=1049AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVK

--------------------------------------------------------------
>40858_40858_13_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000325083_length(transcript)=3899nt_BP=1626nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGC
GAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCA
GTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGC
CAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAAT
CTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGG
ACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAG
AACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAA
ATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAG
ATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTG
AGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAA
GTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTT
TGAAGGAGCACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGA
GCAAAGAGTTTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACT
GTGGAGAAGATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTA
TAACTGTTAAACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATC
ATGGCTCACCTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATG
ATGGTCCCAAAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAG
CTGAAACTCAGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATG
TCCAGACTTCCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGTCCTACAACGTGACTTTAAAAAGACAGCAG
AAAGCAAAAATGTCCCATTGGAACGAGAAGCCACTAGTAAAAATGACCAAAATAACTGTCCTGTGAAACCCTGTTACCTCAATATCTTGG
AAGATGAGCAACCTTTAAATAGTGCTGCCCATAAGGAGTCACCTCCTACTGTTGATTCAACTCAACAGCCTAACCCTTTGCCGTTACGTT
TACCTGAAATGGAACCCTTAGTGCCTAGAGTCAAAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCTCTCTGGCTGGAAGTCCTGATA
CTGAATCTCCAGTGTTAGTGAATGACTATGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAG
ATTTACCACTGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAA
TATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCT
TCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAAT
TAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCC
TTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATGTTTGGTAACGAATTTAAAATG

>40858_40858_13_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1159AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE
REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVN

--------------------------------------------------------------
>40858_40858_14_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000519253_length(transcript)=3710nt_BP=1626nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGC
GAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCA
GTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGC
CAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAAT
CTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGG
ACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAG
AACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAA
ATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAG
ATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTG
AGGATGGAGATGGTGCTGGTGCAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTC
CTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGCACATGGATGAAGTAT
GCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGAGCAAAGAGTTTGTAAAGTTCTTTC
ATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACTGTGGAGAAGATCTTCTTGTAGAGA
TATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTATAACTGTTAAACAGAGATGCAAAA
GGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATCATGGCTCACCTGCTGGAGAGATTG
ATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATGATGGTCCCAAAAATGTAAGATCTG
ATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAGCTGAAACTCAGGCTTTAACTAATT
ATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATGTCCAGACTTCCCTCCAGGCTAACA
CTGAAGCTACTGAAGAAAATGAACATGATGAACAGGTCCTACAACGTGACTTTAAAAAGACAGCAGAAAGCAAAAATGTCCCATTGGAAC
GAGAAGCCACTAGTAAAAATGACCAAAATAACTGTCCTGTGAAACCCTGTTACCTCAATATCTTGGAAGATGAGCAACCTTTAAATAGTG
CTGCCCATAAGGAGTCACCTCCTACTGTTGATTCAACTCAACAGCCTAACCCTTTGCCGTTACGTTTACCTGAAATGGAACCCTTAGTGC
CTAGAGTCAAAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCTCTCTGGCTGGAAGTCCTGATACTGAATCTCCAGTGTTAGTGAATG
ACTATGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATAT
ATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAAT
TAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCC
TTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATA

>40858_40858_14_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1151AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQL
DRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNE
LAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED
EESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKND
QNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGN

--------------------------------------------------------------
>40858_40858_15_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000524226_length(transcript)=3570nt_BP=1626nt
ATTCGGGGAGACTGCAGGCCAACCGGGAGGCTGAGTTCGAAGCTAGCAGGGCGGCGAAGCCAGTGTCGCCCGCGGCGTTGAGAAGACGGC
AAATGTTCTGAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATATCAGAATG
GTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAG
ATTATCTGACCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTGTATCATA
ATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTAC
TCTACAGAATAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTC
CTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATG
AAACACAGGAAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACT
CTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGAT
TTCGCAGATTTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGT
CTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAA
ACGGTGGAATTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATA
TTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGG
AAATTGAACTTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACC
TCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAAC
TGAAGAAAGCAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGC
GAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCA
GTCTTAAAGATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGC
CAAAAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAAT
CTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGG
ACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAG
AACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAA
ATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAG
ATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTG
AGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAA
GTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTT
TGAAGGAGCACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGA
GCAAAGAGTTTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACT
GTGGAGAAGATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTA
TAACTGTTAAACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATC
ATGGCTCACCTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATG
ATGGTCCCAAAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAG
CTGAAACTCAGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATG
TCCAGACTTCCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGAAGCAGAATCTGGTAATATAAGTCAAAAGT
CTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAG
AAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAA
CGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAA
TAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACAT
CAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCC

>40858_40858_15_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=1049AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVK

--------------------------------------------------------------
>40858_40858_16_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000325083_length(transcript)=3710nt_BP=1437nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGCGAGAAAATG
TCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAG
ATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGCCAAAAGAAA
CTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCAC
ATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTAT
CCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTC
CTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTG
ATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCAT
TAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAG
ATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTT
CTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGC
ACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGAGCAAAGAGT
TTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACTGTGGAGAAG
ATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTATAACTGTTA
AACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATCATGGCTCAC
CTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATGATGGTCCCA
AAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAGCTGAAACTC
AGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATGTCCAGACTT
CCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGTCCTACAACGTGACTTTAAAAAGACAGCAGAAAGCAAAA
ATGTCCCATTGGAACGAGAAGCCACTAGTAAAAATGACCAAAATAACTGTCCTGTGAAACCCTGTTACCTCAATATCTTGGAAGATGAGC
AACCTTTAAATAGTGCTGCCCATAAGGAGTCACCTCCTACTGTTGATTCAACTCAACAGCCTAACCCTTTGCCGTTACGTTTACCTGAAA
TGGAACCCTTAGTGCCTAGAGTCAAAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCTCTCTGGCTGGAAGTCCTGATACTGAATCTC
CAGTGTTAGTGAATGACTATGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCAC
TGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAA
TGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCT
CATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGAC
ACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTGAATTCTGGACAGATTTAAGCCTTGACACAC
TGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATGTTTGGTAACGAATTTAAAATGTAGTTTTAA

>40858_40858_16_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1047AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF
LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNS
ITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK
AETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNIL
EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVE

--------------------------------------------------------------
>40858_40858_17_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000519253_length(transcript)=3521nt_BP=1437nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGCGAGAAAATG
TCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAG
ATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGCCAAAAGAAA
CTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCAC
ATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTAT
CCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTC
CTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTG
ATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCAT
TAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAG
ATGGTGCTGGTGCAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTG
ATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGCACATGGATGAAGTATGCTCCTCGC
AGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGAGCAAAGAGTTTGTAAAGTTCTTTCATAAACAAC
TTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACTGTGGAGAAGATCTTCTTGTAGAGATATCTGAAG
TGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTATAACTGTTAAACAGAGATGCAAAAGGAAAATAG
AAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATCATGGCTCACCTGCTGGAGAGATTGATGATGAAG
ACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATGATGGTCCCAAAAATGTAAGATCTGATATTTCTG
ATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAGCTGAAACTCAGGCTTTAACTAATTATGGAAGTG
GAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATGTCCAGACTTCCCTCCAGGCTAACACTGAAGCTA
CTGAAGAAAATGAACATGATGAACAGGTCCTACAACGTGACTTTAAAAAGACAGCAGAAAGCAAAAATGTCCCATTGGAACGAGAAGCCA
CTAGTAAAAATGACCAAAATAACTGTCCTGTGAAACCCTGTTACCTCAATATCTTGGAAGATGAGCAACCTTTAAATAGTGCTGCCCATA
AGGAGTCACCTCCTACTGTTGATTCAACTCAACAGCCTAACCCTTTGCCGTTACGTTTACCTGAAATGGAACCCTTAGTGCCTAGAGTCA
AAGAAGTTAAATCTGCTCAGGAAACTCCTGAAAGCTCTCTGGCTGGAAGTCCTGATACTGAATCTCCAGTGTTAGTGAATGACTATGAAG
CAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAGAAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGG
CAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGAAAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAA
ATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAGCCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACT
CAATGCATATATGAAAACAATACTAAATAAACATCTGATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTC

>40858_40858_17_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1039AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEV
CSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCK
RKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTN
YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNS
AAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTI

--------------------------------------------------------------
>40858_40858_18_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000524226_length(transcript)=3381nt_BP=1437nt
GAGAAGCTCGACTACGACTACCTGCGGAAGCTCTCCAGCTACCTCTTCGACCGAAGCGGCTTCGTGTTCGACTCTGAGTACGAGGGGCTC
GGGAAGCCCTTGGCGACCCCCATCAGCAGTGTCCACACCGACCTGCCCTCCCAGCCTCAGCTTCGGGACAAAGATCAGCCGCACAGCAAA
AACCAGGCGCTGAACTCCACCAATGGGGAGCTGAACGCGGACGACCCCATGGCCGGCCACTCCAGCGCCCATCAGGGCGCCTGCAGAGAT
GGAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCTGAAGCTCCTCTTCTTG
ATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATCTATAACTCTATCAGCT
ACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACTCTGCAGTCTGCCTTCT
ACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTTCCTAATATTATTGATG
TCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACATCATTACCTCTGTAAAG
AAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCTGTCGAGCGAGAAAATG
TCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAG
ATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCCCCAAAGCCAAAAGAAA
CTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCAC
ATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTAT
CCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTC
CTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTG
ATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCAT
TAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAG
ATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTT
CTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGC
ACATGGATGAAGTATGCTCCTCGCAGCTTCTAACTTCAGTAAGGCGCATGGTTTTGACCCTTACCCAGCAAAATGATGAGAGCAAAGAGT
TTGTAAAGTTCTTTCATAAACAACTTGGAAGTATATTACAGGATTCACTGGCAAAATTTGCTGGCAGAAAACTGAAAGACTGTGGAGAAG
ATCTTCTTGTAGAGATATCTGAAGTGTTGTTCAATGAATTGGCTTTCTTTAAGCTTATGCAAGATTTGGATAATAATAGTATAACTGTTA
AACAGAGATGCAAAAGGAAAATAGAAGCAACTGGAGTGATACAATCTTGTGCCAAAGAGGCTAAAAGGATTCTTGAAGATCATGGCTCAC
CTGCTGGAGAGATTGATGATGAAGACAAAGACAAGGATGAAACTGAAACAGTTAAGCAGACTCAAACATCTGAGGTGTATGATGGTCCCA
AAAATGTAAGATCTGATATTTCTGATCAAGAGGAAGATGAAGAAAGTGAAGGATGTCCAGTGTCTATTAATTTGTCTAAAGCTGAAACTC
AGGCTTTAACTAATTATGGAAGTGGAGAAGATGAAAATGAGGATGAAGAAATGGAAGAATTTGAAGAAGGCCCTGTGGATGTCCAGACTT
CCCTCCAGGCTAACACTGAAGCTACTGAAGAAAATGAACATGATGAACAGGAAGCAGAATCTGGTAATATAAGTCAAAAGTCTGATGAAG
AAGATTTTGTAAAAGTTGAAGATTTACCACTGAAACTGACAATATATTCAGAGGCAGATCTAAGAAAGAAAATGGTAGAAGAAGAACAGA
AAAACCATTTATCTGGTGAAATATGTGAAATGCAGACCGAAGAATTAGCTGGAAATTCTGAGACACTAAAAGAACCTGAAACGGTGGGAG
CCCAGAGTATATGAGATGTCTTCAGAGGCTCATCTAACTCTGTCCTTACATACTCAATGCATATATGAAAACAATACTAAATAAACATCT
GATCTGTATAAAAATGTAAATTAGTTTGACACTGCTTTTTTGATAGGTGTGGTCATTTCTCCCCATGGTAGTTTAAAACATCAGAAACTG
AATTCTGGACAGATTTAAGCCTTGACACACTGTGTTTTTTTTTTTTTCCCCCTTCTTTTTTGGGTCTTCATTTTTTTCCCCATTGTGATG

>40858_40858_18_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=937AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF
LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNS
ITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK
AETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVE

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Fusion Gene PPI Analysis for JAK2-PCM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for JAK2-PCM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for JAK2-PCM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource