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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:JARID2-HFE (FusionGDB2 ID:40887)

Fusion Gene Summary for JARID2-HFE

check button Fusion gene summary
Fusion gene informationFusion gene name: JARID2-HFE
Fusion gene ID: 40887
HgeneTgene
Gene symbol

JARID2

HFE

Gene ID

3720

3077

Gene namejumonji and AT-rich interaction domain containing 2homeostatic iron regulator
SynonymsJMJHFE1|HH|HLA-H|MVCD7|TFQTL2
Cytomap

6p22.3

6p22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein Jumonjijumonji homologjumonji, AT rich interactive domain 2jumonji-like proteinjumonji/ARID domain-containing protein 2hereditary hemochromatosis proteinMHC class I-like protein HFEhereditary hemochromatosis protein HLA-Hhigh Fe
Modification date2020031320200328
UniProtAcc

Q92833

Q30201

Ensembl transtripts involved in fusion geneENST00000341776, ENST00000541660, 
ENST00000397311, ENST00000474854, 
ENST00000309234, ENST00000317896, 
ENST00000336625, ENST00000349999, 
ENST00000352392, ENST00000353147, 
ENST00000357618, ENST00000397022, 
ENST00000461397, ENST00000470149, 
ENST00000488199, 
Fusion gene scores* DoF score17 X 5 X 11=9352 X 2 X 2=8
# samples 183
** MAII scorelog2(18/935*10)=-2.37696945844532
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: JARID2 [Title/Abstract] AND HFE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointJARID2(15452406)-HFE(26091069), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHFE

GO:0006879

cellular iron ion homeostasis

10085150

TgeneHFE

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

24904118

TgeneHFE

GO:0030509

BMP signaling pathway

24904118

TgeneHFE

GO:1900121

negative regulation of receptor binding

9465039

TgeneHFE

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

24904118

TgeneHFE

GO:2000272

negative regulation of signaling receptor activity

9465039


check buttonFusion gene breakpoints across JARID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HFE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-MZ-A7D7-01AJARID2chr6

15452406

-HFEchr6

26091069

+
ChimerDB4HNSCTCGA-MZ-A7D7-01AJARID2chr6

15452406

+HFEchr6

26091542

+
ChimerDB4HNSCTCGA-MZ-A7D7JARID2chr6

15452406

+HFEchr6

26091069

+


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Fusion Gene ORF analysis for JARID2-HFE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341776ENST00000309234JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000309234JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000317896JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000317896JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000336625JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000336625JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000349999JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000349999JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000352392JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000352392JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000353147JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000353147JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000357618JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000357618JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000397022JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000461397JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000461397JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000470149JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000470149JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000341776ENST00000488199JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000341776ENST00000488199JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000309234JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000309234JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000317896JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000317896JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000336625JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000336625JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000349999JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000349999JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000352392JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000352392JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000353147JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000353147JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000357618JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000357618JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000397022JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000461397JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000461397JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000470149JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000470149JARID2chr6

15452406

+HFEchr6

26091069

+
5CDS-intronENST00000541660ENST00000488199JARID2chr6

15452406

+HFEchr6

26091542

+
5CDS-intronENST00000541660ENST00000488199JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-3CDSENST00000397311ENST00000397022JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000309234JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000309234JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000317896JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000317896JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000336625JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000336625JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000349999JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000349999JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000352392JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000352392JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000353147JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000353147JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000357618JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000357618JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000397022JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000461397JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000461397JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000470149JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000470149JARID2chr6

15452406

+HFEchr6

26091069

+
5UTR-intronENST00000397311ENST00000488199JARID2chr6

15452406

+HFEchr6

26091542

+
5UTR-intronENST00000397311ENST00000488199JARID2chr6

15452406

+HFEchr6

26091069

+
In-frameENST00000341776ENST00000397022JARID2chr6

15452406

+HFEchr6

26091542

+
In-frameENST00000541660ENST00000397022JARID2chr6

15452406

+HFEchr6

26091542

+
intron-3CDSENST00000474854ENST00000397022JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000309234JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000309234JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000317896JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000317896JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000336625JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000336625JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000349999JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000349999JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000352392JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000352392JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000353147JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000353147JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000357618JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000357618JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000397022JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000461397JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000461397JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000470149JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000470149JARID2chr6

15452406

+HFEchr6

26091069

+
intron-intronENST00000474854ENST00000488199JARID2chr6

15452406

+HFEchr6

26091542

+
intron-intronENST00000474854ENST00000488199JARID2chr6

15452406

+HFEchr6

26091069

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341776JARID2chr615452406+ENST00000397022HFEchr626091542+15867372321443403
ENST00000541660JARID2chr615452406+ENST00000397022HFEchr626091542+1321472631178371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341776ENST00000397022JARID2chr615452406+HFEchr626091542+0.0162001660.9837998
ENST00000541660ENST00000397022JARID2chr615452406+HFEchr626091542+0.0138765150.98612344

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Fusion Genomic Features for JARID2-HFE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
JARID2chr615452406+HFEchr626091068+0.0006100660.9993899
JARID2chr615452406+HFEchr626091541+3.46E-050.9999654
JARID2chr615452406+HFEchr626091068+0.0006100660.9993899
JARID2chr615452406+HFEchr626091541+3.46E-050.9999654

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for JARID2-HFE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:15452406/chr6:26091069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JARID2

Q92833

HFE

Q30201

FUNCTION: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. {ECO:0000269|PubMed:9465039}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+418104_1101641247.0MotifNuclear localization signal
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605207_2980257.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505207_2980243.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905207_29825261.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203207_298077.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704207_2980169.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816207_298113349.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216207_29890326.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716207_298113335.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905207_29825247.0DomainNote=Ig-like C1-type
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605115_2050257.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605206_2970257.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000003178960523_1140257.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605298_3060257.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505115_2050243.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505206_2970243.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000003366250523_1140243.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505298_3060243.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905115_20525261.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905206_29725261.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000003499990523_11425261.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905298_30625261.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203115_205077.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203206_297077.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000003523920323_114077.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203298_306077.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704115_2050169.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704206_2970169.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000003531470423_1140169.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704298_3060169.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816115_205113349.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816206_297113349.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816298_306113349.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216115_20590326.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216206_29790326.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216298_30690326.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716115_205113335.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716206_297113335.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716298_306113335.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905115_20525247.0RegionNote=Alpha-2
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905206_29725247.0RegionNote=Alpha-3
TgeneHFEchr6:15452406chr6:26091542ENST000004881990523_11425247.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905298_30625247.0RegionNote=Connecting peptide
TgeneHFEchr6:15452406chr6:26091542ENST000003178960523_3060257.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605331_3480257.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST000003366250523_3060243.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505331_3480243.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST000003499990523_30625261.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905331_34825261.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST000003523920323_306077.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203331_348077.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST000003531470423_3060169.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704331_3480169.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816331_348113349.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216331_34890326.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716331_348113335.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST000004881990523_30625247.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905331_34825247.0Topological domainCytoplasmic
TgeneHFEchr6:15452406chr6:26091542ENST0000031789605307_3300257.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000033662505307_3300243.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000034999905307_33025261.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000035239203307_330077.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000035314704307_3300169.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000035761816307_330113349.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000039702216307_33090326.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000046139716307_330113335.0TransmembraneHelical
TgeneHFEchr6:15452406chr6:26091542ENST0000048819905307_33025247.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+4181234_12461641247.0Compositional biasNote=Poly-Ser
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+4181234_124601075.0Compositional biasNote=Poly-Ser
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+418557_5981641247.0DomainJmjN
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+418621_7131641247.0DomainARID
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+418884_10481641247.0DomainJmjC
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+418557_59801075.0DomainJmjN
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+418621_71301075.0DomainARID
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+418884_104801075.0DomainJmjC
HgeneJARID2chr6:15452406chr6:26091542ENST00000341776+418874_8781641247.0MotifNote=GSGFP motif
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+418104_11001075.0MotifNuclear localization signal
HgeneJARID2chr6:15452406chr6:26091542ENST00000397311+418874_87801075.0MotifNote=GSGFP motif
TgeneHFEchr6:15452406chr6:26091542ENST000003576181623_114113349.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST000003970221623_11490326.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST000004613971623_114113335.0RegionNote=Alpha-1
TgeneHFEchr6:15452406chr6:26091542ENST000003576181623_306113349.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST000003970221623_30690326.0Topological domainExtracellular
TgeneHFEchr6:15452406chr6:26091542ENST000004613971623_306113335.0Topological domainExtracellular


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Fusion Gene Sequence for JARID2-HFE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40887_40887_1_JARID2-HFE_JARID2_chr6_15452406_ENST00000341776_HFE_chr6_26091542_ENST00000397022_length(transcript)=1586nt_BP=737nt
GTTTTACTAAAGTGAATTTTTTTTTGTTTGCTTCGTTCGTCTTTGGCTCTTTTTTTTTCCTTCCCAATTTCGGATTTATTTCAAGGCGAA
TCTGGCTTTGGGGGAAGAGGAAGAAAAGTCGGATTACAAGATCAACCACCACCAACAACAATAAAAACCACCAGGATATTTTTTTGCAAA
TTTCTGACGGCTTTAAATTCATGAAGCAATTGTCCCCTTTTGCAATCAGCATTTGGATCTCAGAATGAGCAAGGAAAGACCCAAGAGGAA
TATCATTCAGAAGAAATACGATGACAGTGATGGGATTCCGTGGTCAGAAGAACGGGTGGTACGTAAAGTCCTTTATTTGTCTCTGAAGGA
GTTCAAGAATTCCCAGAAGAGGCAGCATGCGGAAGGCATTGCTGGGAGCCTGAAAACTGTGAATGGGCTCCTTGGTAATGACCAGTCTAA
GGGATTAGGACCAGCATCAGAACAGTCAGAGAATGAAAAGGACGATGCATCCCAAGTGTCCTCCACTAGCAACGATGTTAGTTCTTCAGA
TTTTGAAGAAGGGCCGTCGAGGAAAAGGCCCAGGCTGCAAGCACAAAGGAAGTTTGCTCAGTCTCAGCCGAATAGTCCCAGCACAACTCC
AGTAAAGATAGTGGAGCCATTGCTACCCCCTCCAGCTACTCAGATATCAGACCTCTCTAAAAGGAAGCCTAAGACAGAAGATTTTCTTAC
CTTTCTCTGCCTTCGAGAGTCCCACACCCTGCAGGTCATCCTGGGCTGTGAAATGCAAGAAGACAACAGTACCGAGGGCTACTGGAAGTA
CGGGTATGATGGGCAGGACCACCTTGAATTCTGCCCTGACACACTGGATTGGAGAGCAGCAGAACCCAGGGCCTGGCCCACCAAGCTGGA
GTGGGAAAGGCACAAGATTCGGGCCAGGCAGAACAGGGCCTACCTGGAGAGGGACTGCCCTGCACAGCTGCAGCAGTTGCTGGAGCTGGG
GAGAGGTGTTTTGGACCAACAAGTGCCTCCTTTGGTGAAGGTGACACATCATGTGACCTCTTCAGTGACCACTCTACGGTGTCGGGCCTT
GAACTACTACCCCCAGAACATCACCATGAAGTGGCTGAAGGATAAGCAGCCAATGGATGCCAAGGAGTTCGAACCTAAAGACGTATTGCC
CAATGGGGATGGGACCTACCAGGGCTGGATAACCTTGGCTGTACCCCCTGGGGAAGAGCAGAGATATACGTGCCAGGTGGAGCACCCAGG
CCTGGATCAGCCCCTCATTGTGATCTGGGAGCCCTCACCGTCTGGCACCCTAGTCATTGGAGTCATCAGTGGAATTGCTGTTTTTGTCGT
CATCTTGTTCATTGGAATTTTGTTCATAATATTAAGGAAGAGGCAGGGTTCAAGAGGAGCCATGGGGCACTACGTCTTAGCTGAACGTGA
GTGACACGCAGCCTGCAGACTCACTGTGGGAAGGAGACAAAACTAGAGACTCAAAGAGGGAGTGCATTTATGAGCTCTTCATGTTTCAGG

>40887_40887_1_JARID2-HFE_JARID2_chr6_15452406_ENST00000341776_HFE_chr6_26091542_ENST00000397022_length(amino acids)=403AA_BP=168
MDLRMSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVNGLLGNDQSKGLGPASEQSENEKDDAS
QVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRESHTLQVILGCE
MQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHH
VTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTL

--------------------------------------------------------------
>40887_40887_2_JARID2-HFE_JARID2_chr6_15452406_ENST00000541660_HFE_chr6_26091542_ENST00000397022_length(transcript)=1321nt_BP=472nt
AAGTGCTCCGGAGCCTGCCTCACTGCGCTCTTCCTCCCTCCCTCCCTCTGTCCTTCTTCCTCTCTGTCTCTCTGCAATGATCCGGCTCTG
AGGATGGCTGCTCCACGGGTCTGTCAGGTGCAGTTTTTGGTGGCTTATCTTGAGGAACCTGGGATAGAAGGGCTCCTTGGTAATGACCAG
TCTAAGGGATTAGGACCAGCATCAGAACAGTCAGAGAATGAAAAGGACGATGCATCCCAAGTGTCCTCCACTAGCAACGATGTTAGTTCT
TCAGATTTTGAAGAAGGGCCGTCGAGGAAAAGGCCCAGGCTGCAAGCACAAAGGAAGTTTGCTCAGTCTCAGCCGAATAGTCCCAGCACA
ACTCCAGTAAAGATAGTGGAGCCATTGCTACCCCCTCCAGCTACTCAGATATCAGACCTCTCTAAAAGGAAGCCTAAGACAGAAGATTTT
CTTACCTTTCTCTGCCTTCGAGAGTCCCACACCCTGCAGGTCATCCTGGGCTGTGAAATGCAAGAAGACAACAGTACCGAGGGCTACTGG
AAGTACGGGTATGATGGGCAGGACCACCTTGAATTCTGCCCTGACACACTGGATTGGAGAGCAGCAGAACCCAGGGCCTGGCCCACCAAG
CTGGAGTGGGAAAGGCACAAGATTCGGGCCAGGCAGAACAGGGCCTACCTGGAGAGGGACTGCCCTGCACAGCTGCAGCAGTTGCTGGAG
CTGGGGAGAGGTGTTTTGGACCAACAAGTGCCTCCTTTGGTGAAGGTGACACATCATGTGACCTCTTCAGTGACCACTCTACGGTGTCGG
GCCTTGAACTACTACCCCCAGAACATCACCATGAAGTGGCTGAAGGATAAGCAGCCAATGGATGCCAAGGAGTTCGAACCTAAAGACGTA
TTGCCCAATGGGGATGGGACCTACCAGGGCTGGATAACCTTGGCTGTACCCCCTGGGGAAGAGCAGAGATATACGTGCCAGGTGGAGCAC
CCAGGCCTGGATCAGCCCCTCATTGTGATCTGGGAGCCCTCACCGTCTGGCACCCTAGTCATTGGAGTCATCAGTGGAATTGCTGTTTTT
GTCGTCATCTTGTTCATTGGAATTTTGTTCATAATATTAAGGAAGAGGCAGGGTTCAAGAGGAGCCATGGGGCACTACGTCTTAGCTGAA
CGTGAGTGACACGCAGCCTGCAGACTCACTGTGGGAAGGAGACAAAACTAGAGACTCAAAGAGGGAGTGCATTTATGAGCTCTTCATGTT

>40887_40887_2_JARID2-HFE_JARID2_chr6_15452406_ENST00000541660_HFE_chr6_26091542_ENST00000397022_length(amino acids)=371AA_BP=136
MSLCNDPALRMAAPRVCQVQFLVAYLEEPGIEGLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFA
QSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRA
AEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMD
AKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for JARID2-HFE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for JARID2-HFE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for JARID2-HFE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource