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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:JMJD1C-GABPB1 (FusionGDB2 ID:40967)

Fusion Gene Summary for JMJD1C-GABPB1

Fusion gene summary

Fusion gene information	Fusion gene name: JMJD1C-GABPB1
	Fusion gene ID: 40967
		Hgene	Tgene
	Gene symbol	JMJD1C	GABPB1
	Gene ID	221037	2553
	Gene name	jumonji domain containing 1C	GA binding protein transcription factor subunit beta 1
	Synonyms	KDM3C\|TRIP-8\|TRIP8	BABPB2\|E4TF1\|E4TF1-47\|E4TF1-53\|E4TF1B\|GABPB\|GABPB-1\|GABPB2\|NRF2B1\|NRF2B2
	Cytomap	10q21.3	15q21.2
	Type of gene	protein-coding	protein-coding
	Description	probable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8	GA-binding protein subunit beta-1GA binding protein transcription factor beta subunit 1 transcript variant gamma-2GABP subunit beta-2nuclear respiratory factor 2transcription factor E4TF1-47transcription factor E4TF1-53
	Modification date	20200313	20200313
	UniProtAcc	Q15652	Q06547
	Ensembl transtripts involved in fusion gene	ENST00000399262, ENST00000399251, ENST00000402544, ENST00000489372, ENST00000542921,	ENST00000359031, ENST00000396464, ENST00000429662, ENST00000543881, ENST00000560825, ENST00000220429, ENST00000380877,
Fusion gene scores	* DoF score	29 X 18 X 10=5220	5 X 5 X 2=50
	# samples	31	5
	** MAII score	log2(31/5220*10)=-4.07370968618301 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/50*10)=0
Context	PubMed: JMJD1C [Title/Abstract] AND GABPB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	JMJD1C(65225255)-GABPB1(50601995), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GABPB1	GO:0045944	positive regulation of transcription by RNA polymerase II	9857059

Fusion gene breakpoints across JMJD1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABPB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A03P-01A	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-

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Fusion Gene ORF analysis for JMJD1C-GABPB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000399262	ENST00000359031	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5CDS-intron	ENST00000399262	ENST00000396464	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5CDS-intron	ENST00000399262	ENST00000429662	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5CDS-intron	ENST00000399262	ENST00000543881	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5CDS-intron	ENST00000399262	ENST00000560825	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-3CDS	ENST00000399251	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-3CDS	ENST00000399251	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-intron	ENST00000399251	ENST00000359031	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-intron	ENST00000399251	ENST00000396464	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-intron	ENST00000399251	ENST00000429662	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-intron	ENST00000399251	ENST00000543881	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
5UTR-intron	ENST00000399251	ENST00000560825	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
In-frame	ENST00000399262	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
In-frame	ENST00000399262	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000402544	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000402544	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000489372	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000489372	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000542921	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-3CDS	ENST00000542921	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000402544	ENST00000359031	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000402544	ENST00000396464	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000402544	ENST00000429662	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000402544	ENST00000543881	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000402544	ENST00000560825	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000489372	ENST00000359031	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000489372	ENST00000396464	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000489372	ENST00000429662	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000489372	ENST00000543881	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000489372	ENST00000560825	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000542921	ENST00000359031	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000542921	ENST00000396464	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000542921	ENST00000429662	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000542921	ENST00000543881	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-
intron-intron	ENST00000542921	ENST00000560825	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399262	JMJD1C	chr10	65225255	-	ENST00000380877	GABPB1	chr15	50601995	-	2979	387	183	1538	451
ENST00000399262	JMJD1C	chr10	65225255	-	ENST00000220429	GABPB1	chr15	50601995	-	2944	387	183	1574	463

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399262	ENST00000380877	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-	0.000344917	0.9996551
ENST00000399262	ENST00000220429	JMJD1C	chr10	65225255	-	GABPB1	chr15	50601995	-	0.000426587	0.9995734

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Fusion Genomic Features for JMJD1C-GABPB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for JMJD1C-GABPB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:65225255/chr15:50601995)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JMJD1C Q15652	GABPB1 Q06547
FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.	FUNCTION: Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). {ECO:0000250\|UniProtKB:Q00420, ECO:0000269\|PubMed:10675337, ECO:0000269\|PubMed:8441384, ECO:0000269\|PubMed:8816484}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. {ECO:0000269\|PubMed:8441384}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000220429

103_132

396.0

Repeat

Note=ANK 4

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000220429

136_166

396.0

Repeat

Note=ANK 5

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000220429

37_66

396.0

Repeat

Note=ANK 2

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000220429

5_34

396.0

Repeat

Note=ANK 1

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000220429

70_99

396.0

Repeat

Note=ANK 3

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000359031

103_132

349.0

Repeat

Note=ANK 4

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000359031

136_166

349.0

Repeat

Note=ANK 5

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000359031

37_66

349.0

Repeat

Note=ANK 2

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000359031

5_34

349.0

Repeat

Note=ANK 1

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000359031

70_99

349.0

Repeat

Note=ANK 3

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000380877

103_132

384.0

Repeat

Note=ANK 4

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000380877

136_166

384.0

Repeat

Note=ANK 5

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000380877

37_66

384.0

Repeat

Note=ANK 2

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000380877

5_34

384.0

Repeat

Note=ANK 1

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000380877

70_99

384.0

Repeat

Note=ANK 3

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000396464

103_132

349.0

Repeat

Note=ANK 4

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000396464

136_166

349.0

Repeat

Note=ANK 5

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000396464

37_66

349.0

Repeat

Note=ANK 2

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000396464

5_34

349.0

Repeat

Note=ANK 1

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000396464

70_99

349.0

Repeat

Note=ANK 3

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000429662

103_132

361.0

Repeat

Note=ANK 4

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000429662

136_166

361.0

Repeat

Note=ANK 5

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000429662

37_66

361.0

Repeat

Note=ANK 2

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000429662

5_34

361.0

Repeat

Note=ANK 1

Tgene

GABPB1

chr10:65225255

chr15:50601995

ENST00000429662

70_99

361.0

Repeat

Note=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399251

2274_2498

477.0

Domain

JmjC

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399262

2274_2498

2541.0

Domain

JmjC

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000542921

2274_2498

2359.0

Domain

JmjC

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399251

2066_2070

477.0

Motif

Note=LXXLL motif

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399262

2066_2070

2541.0

Motif

Note=LXXLL motif

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000542921

2066_2070

2359.0

Motif

Note=LXXLL motif

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399251

1846_1871

477.0

Zinc finger

C6-type

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000399262

1846_1871

2541.0

Zinc finger

C6-type

Hgene

JMJD1C

chr10:65225255

chr15:50601995

ENST00000542921

1846_1871

2359.0

Zinc finger

C6-type

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Fusion Gene Sequence for JMJD1C-GABPB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40967_40967_1_JMJD1C-GABPB1_JMJD1C_chr10_65225255_ENST00000399262_GABPB1_chr15_50601995_ENST00000220429_length(transcript)=2944nt_BP=387nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTAGATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAA
GTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACAGACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTAT
TCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGAGATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAG
GGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGTGCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCC
ACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATCAAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTT
GATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAGATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCT
GACACTGTGACAATACATGCTGCAACACCACAGTTTATCATTGGACCTGGAGGGGTGGTGAACCTAACAGGTCTGGTATCTTCAGAAAAT
TCATCCAAGGCAACAGATGAAACGGGTGTATCTGCTGTTCAGTTTGGAAACTCTTCTACATCAGTATTAGCTACATTAGCTGCCTTAGCT
GAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACTCCAGTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCTGTGGATGGTGCCATT
CAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATCACAATAGTTACAGATGGAATTCAGCTTGGAAATTTGCACTCTATTCCAACCAGT
GGAATTGGTCAGCCCATCATTGTGACCATGCCAGATGGACAACAAGTATTAACAGTACCAGCAACAGACATTGCTGAAGAAACTGTTATA
AGTGAAGAACCACCAGCTAAGAGACAATGTATCGAAATAATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAGAGAGAAGCTCTTCAG
AAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAATATCGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAGGCCTACAGACAGAAG
TTGGAAGCTATGACTCGTCTTCAGACTAATAAAGAAGCTGTTTAATTGAAATGAACATGTAGTTTGATTTTACTTTTGGTCAAGAAAGAA
TACAATCTTGAACTGTACACAACAAAGGTACAGCCATGGGAATACAGAATGATAGAAGAGACTACAGATGGATAATTGGACTTAAGCCAT
GAGCTCTGAGTTCTTGTAACATAAAACTTTACTTTAGAAGTTGTGAAATGTATTTAAAACTGAATTCTGTAAATAGTTTTTTTTTTTTTA
CAGTTCCAAATGAGTTGATAAAGATTGTTGAAGAGATCCAAAACCAGAATAAGCCACTGTTTTTGTGAATTCTTTTTGATTTTAGTACAA
ACCTTAATTTCTCAGAAACGGAACAGTTTTAAGGGTGATCGTTGTTGGTTAGGCCAAATGTTGTGTAATAATTATGGTGGACTGATGCTG
GAATTACTCCTGTAGGTATAAACCTCTGTATGAAGAGAAGATTTCTCCCAGGAAATCTTTGTACAGCTTTAAGTTGTGTCAGATTCTCTG
AAAACATTTTTTAGAAAGCAAAATTTTTATATTTGTTCAATTTCAGCTATACCCAAGTAGATTTACATGTATATGAAGCAAATATTTTTA
AAAATTTCTGTTTGTACATATTCTGCATGTTTTATAATTTCAAAATGCATCACTTACATAGGTATTTCTCCCACAGAAATGATGAAAGTG
ACCAGAAAAAAACAAAAACAAAACCCCTTTACTCTGTAGGTCATTGAAACGAAGTAAGCTGGCAGCTGGTTTTATTGGAATGACAGTGTT
CTCGGAAGGAGCAGCCTACAAGATAACTTGAATTTGCCAATTCTGCAAAATCTGTGCTTTTTTGAAAATTTAAGAGTGGGGACGTGAAAC
TGTATTCTGTGCCTTCCATCATGATTTCCACATGAAAGCACTTTAAGGCACTGATTTTAAGATAATGTTTTTGGAAAACCCAATGCATAT
GGGTTTCTGAAATATTTTATGGACTTATTTCTCCCCAGGAAATGATTCTTACGGAAAAAAATTGCTTTTGTATGTAGAACAGGAACTTTT
TGTATTACAGTGATGCAATAGACATGTCTAATGTAACTTCTACTTTTCCTTTTGAAAGCTCAGTGTCTGTGCTATGACTTGCTCTCATCA
CAATATTGTTGAATTCCACAATGTATGGACATTAAACACTGGCAGACTGTTCACTTTTTCTTTTTTTTTTTTGGTAAAATATTACTTCAA
ACCCCTTTTTCTTGCTTTATTTTTCAGTGTTTTATTGCTTTATGAACTGTTTAACCCTGAAATCCCTCTAGGTTATCTATACTGTATAAA

>40967_40967_1_JMJD1C-GABPB1_JMJD1C_chr10_65225255_ENST00000399262_GABPB1_chr15_50601995_ENST00000220429_length(amino acids)=463AA_BP=68
MEEAAAASAATAMAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAMSLVDLGKKLLEAARAGQDDEV
RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWAT
EHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENS
SKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSG
IGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKL

--------------------------------------------------------------
>40967_40967_2_JMJD1C-GABPB1_JMJD1C_chr10_65225255_ENST00000399262_GABPB1_chr15_50601995_ENST00000380877_length(transcript)=2979nt_BP=387nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGATGTCCCTGGTAGATTTGGGAAAGAAGCTTTTAGAAGCGGCACGAGCAGGTCAAGATGATGAA
GTTCGTATTTTGATGGCAAATGGAGCTCCCTTTACTACAGACTGGCTGGGAACTTCTCCACTTCATCTAGCAGCACAGTATGGTCATTAT
TCCACCACAGAGGTACTGCTGCGAGCTGGTGTGAGCAGAGATGCCAGAACCAAAGTGGACCGAACACCATTACATATGGCAGCTTCTGAG
GGCCATGCCAGCATAGTAGAGGTTTTACTTAAGCATGGTGCTGATGTCAATGCAAAGGACATGTTAAAGATGACAGCTCTCCATTGGGCC
ACAGAACACAATCATCAAGAGGTGGTGGAACTTTTAATCAAATATGGTGCTGATGTACACACGCAAAGTAAATTTTGTAAAACTGCATTT
GATATTTCAATAGACAATGGAAATGAAGATTTAGCAGAGATATTACAGATTGCTATGCAGAACCAAATCAACACAAACCCAGAGAGTCCT
GACACTGTGACAATACATGCTGCAACACCACAGTTTATCATTGGACCTGGAGGGGTGGTGAACCTAACAGATGAAACGGGTGTATCTGCT
GTTCAGTTTGGAAACTCTTCTACATCAGTATTAGCTACATTAGCTGCCTTAGCTGAAGCATCTGCTCCATTGTCCAATTCTTCAGAAACT
CCAGTAGTGGCCACAGAAGAAGTAGTTACTGCAGAATCTGTGGATGGTGCCATTCAGCAAGTAGTTAGTTCAGGGGGTCAGCAAGTCATC
ACAATAGTTACAGATGGAATTCAGCTTGGAAATTTGCACTCTATTCCAACCAGTGGAATTGGTCAGCCCATCATTGTGACCATGCCAGAT
GGACAACAAGTATTAACAGTACCAGCAACAGACATTGCTGAAGAAACTGTTATAAGTGAAGAACCACCAGCTAAGAGACAATGTATCGAA
ATAATTGAAAACCGGGTGGAATCTGCAGAAATAGAAGAGAGAGAAGCTCTTCAGAAACAGCTGGATGAAGCAAATCGAGAAGCACAAAAA
TATCGACAGCAGCTCCTAAAGAAAGAACAGGAAGCAGAGGCCTACAGACAGAAGTTGGAAGCTATGACTCGTCTTCAGACTAATAAAGAA
GCTGTTTAATTGAAATGAACATGTAGTTTGATTTTACTTTTGGTCAAGAAAGAATACAATCTTGAACTGTACACAACAAAGGTACAGCCA
TGGGAATACAGAATGATAGAAGAGACTACAGATGGATAATTGGACTTAAGCCATGAGCTCTGAGTTCTTGTAACATAAAACTTTACTTTA
GAAGTTGTGAAATGTATTTAAAACTGAATTCTGTAAATAGTTTTTTTTTTTTTACAGTTCCAAATGAGTTGATAAAGATTGTTGAAGAGA
TCCAAAACCAGAATAAGCCACTGTTTTTGTGAATTCTTTTTGATTTTAGTACAAACCTTAATTTCTCAGAAACGGAACAGTTTTAAGGGT
GATCGTTGTTGGTTAGGCCAAATGTTGTGTAATAATTATGGTGGACTGATGCTGGAATTACTCCTGTAGGTATAAACCTCTGTATGAAGA
GAAGATTTCTCCCAGGAAATCTTTGTACAGCTTTAAGTTGTGTCAGATTCTCTGAAAACATTTTTTAGAAAGCAAAATTTTTATATTTGT
TCAATTTCAGCTATACCCAAGTAGATTTACATGTATATGAAGCAAATATTTTTAAAAATTTCTGTTTGTACATATTCTGCATGTTTTATA
ATTTCAAAATGCATCACTTACATAGGTATTTCTCCCACAGAAATGATGAAAGTGACCAGAAAAAAACAAAAACAAAACCCCTTTACTCTG
TAGGTCATTGAAACGAAGTAAGCTGGCAGCTGGTTTTATTGGAATGACAGTGTTCTCGGAAGGAGCAGCCTACAAGATAACTTGAATTTG
CCAATTCTGCAAAATCTGTGCTTTTTTGAAAATTTAAGAGTGGGGACGTGAAACTGTATTCTGTGCCTTCCATCATGATTTCCACATGAA
AGCACTTTAAGGCACTGATTTTAAGATAATGTTTTTGGAAAACCCAATGCATATGGGTTTCTGAAATATTTTATGGACTTATTTCTCCCC
AGGAAATGATTCTTACGGAAAAAAATTGCTTTTGTATGTAGAACAGGAACTTTTTGTATTACAGTGATGCAATAGACATGTCTAATGTAA
CTTCTACTTTTCCTTTTGAAAGCTCAGTGTCTGTGCTATGACTTGCTCTCATCACAATATTGTTGAATTCCACAATGTATGGACATTAAA
CACTGGCAGACTGTTCACTTTTTCTTTTTTTTTTTTGGTAAAATATTACTTCAAACCCCTTTTTCTTGCTTTATTTTTCAGTGTTTTATT
GCTTTATGAACTGTTTAACCCTGAAATCCCTCTAGGTTATCTATACTGTATAAAAAAGCAATTACCCTTAAAACTGTACTCTGGCCTACT
TTTCTATTTTGCAATTAAATATCTTTTTCACATATGTTCATTGTAGACTTATGTTTTTATCACATCTTATTAACACATTAAAAATGTTAT

>40967_40967_2_JMJD1C-GABPB1_JMJD1C_chr10_65225255_ENST00000399262_GABPB1_chr15_50601995_ENST00000380877_length(amino acids)=451AA_BP=68
MEEAAAASAATAMAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAMSLVDLGKKLLEAARAGQDDEV
RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWAT
EHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV
QFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDG
QQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEA

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Fusion Gene PPI Analysis for JMJD1C-GABPB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for JMJD1C-GABPB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for JMJD1C-GABPB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source