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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:JMJD1C-TSN (FusionGDB2 ID:40985)

Fusion Gene Summary for JMJD1C-TSN

check button Fusion gene summary
Fusion gene informationFusion gene name: JMJD1C-TSN
Fusion gene ID: 40985
HgeneTgene
Gene symbol

JMJD1C

TSN

Gene ID

221037

7247

Gene namejumonji domain containing 1Ctranslin
SynonymsKDM3C|TRIP-8|TRIP8BCLF-1|C3PO|RCHF1|REHF-1|TBRBP|TRSLN
Cytomap

10q21.3

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionprobable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8translincomponent 3 of promoter of RISCrecombination hotspot associated factorrecombination hotspot-binding proteintestis brain-RNA binding protein
Modification date2020031320200313
UniProtAcc

Q15652

Q15631

Ensembl transtripts involved in fusion geneENST00000399262, ENST00000399251, 
ENST00000489372, ENST00000542921, 
ENST00000402544, 		ENST00000409193, 
ENST00000498545, ENST00000536142, 
ENST00000389682, 
Fusion gene scores* DoF score29 X 18 X 10=52207 X 8 X 2=112
# samples 317
** MAII scorelog2(31/5220*10)=-4.07370968618301
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JMJD1C [Title/Abstract] AND TSN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across JMJD1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TSN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..JMJD1Cchr10

65024410

-TSNchr2

122514814

+
ChimerKB3..JMJD1Cchr10

65024411

-TSNchr2

122514814

+
ChimerKB3..JMJD1Cchr10

65140077

-TSNchr2

122514815

+


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Fusion Gene ORF analysis for JMJD1C-TSN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000399262ENST00000409193JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000409193JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000409193JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5CDS-intronENST00000399262ENST00000498545JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000498545JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000498545JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5CDS-intronENST00000399262ENST00000536142JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000536142JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5CDS-intronENST00000399262ENST00000536142JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5UTR-3CDSENST00000399251ENST00000389682JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-3CDSENST00000399251ENST00000389682JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-3CDSENST00000399251ENST00000389682JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5UTR-3CDSENST00000489372ENST00000389682JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-3CDSENST00000489372ENST00000389682JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-3CDSENST00000542921ENST00000389682JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-3CDSENST00000542921ENST00000389682JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000409193JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000409193JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000409193JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5UTR-intronENST00000399251ENST00000498545JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000498545JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000498545JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5UTR-intronENST00000399251ENST00000536142JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000536142JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000399251ENST00000536142JMJD1Cchr10

65140077

-TSNchr2

122514815

+
5UTR-intronENST00000489372ENST00000409193JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000489372ENST00000409193JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000489372ENST00000498545JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000489372ENST00000498545JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000489372ENST00000536142JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000489372ENST00000536142JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000409193JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000409193JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000498545JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000498545JMJD1Cchr10

65024411

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000536142JMJD1Cchr10

65024410

-TSNchr2

122514814

+
5UTR-intronENST00000542921ENST00000536142JMJD1Cchr10

65024411

-TSNchr2

122514814

+
In-frameENST00000399262ENST00000389682JMJD1Cchr10

65024410

-TSNchr2

122514814

+
In-frameENST00000399262ENST00000389682JMJD1Cchr10

65024411

-TSNchr2

122514814

+
In-frameENST00000399262ENST00000389682JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-3CDSENST00000402544ENST00000389682JMJD1Cchr10

65024410

-TSNchr2

122514814

+
intron-3CDSENST00000402544ENST00000389682JMJD1Cchr10

65024411

-TSNchr2

122514814

+
intron-3CDSENST00000402544ENST00000389682JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-3CDSENST00000489372ENST00000389682JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-3CDSENST00000542921ENST00000389682JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000402544ENST00000409193JMJD1Cchr10

65024410

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000409193JMJD1Cchr10

65024411

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000409193JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000402544ENST00000498545JMJD1Cchr10

65024410

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000498545JMJD1Cchr10

65024411

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000498545JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000402544ENST00000536142JMJD1Cchr10

65024410

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000536142JMJD1Cchr10

65024411

-TSNchr2

122514814

+
intron-intronENST00000402544ENST00000536142JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000489372ENST00000409193JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000489372ENST00000498545JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000489372ENST00000536142JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000542921ENST00000409193JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000542921ENST00000498545JMJD1Cchr10

65140077

-TSNchr2

122514815

+
intron-intronENST00000542921ENST00000536142JMJD1Cchr10

65140077

-TSNchr2

122514815

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399262JMJD1Cchr1065024410-ENST00000389682TSNchr2122514814+37736661831286367
ENST00000399262JMJD1Cchr1065024411-ENST00000389682TSNchr2122514814+37736661831286367
ENST00000399262JMJD1Cchr1065140077-ENST00000389682TSNchr2122514815+36595521831172329

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for JMJD1C-TSN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for JMJD1C-TSN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:/chr2:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JMJD1C

Q15652

TSN

Q15631

FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.FUNCTION: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.; FUNCTION: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for JMJD1C-TSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>40985_40985_1_JMJD1C-TSN_JMJD1C_chr10_65024410_ENST00000399262_TSN_chr2_122514814_ENST00000389682_length(transcript)=3773nt_BP=666nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGGTGTATGTGGAATTTGATGATCTTGAATGGGATAAACGAGAGTGGGTTAAAGTTTATGAAGAT
TTTTCAACTTTCTTGGTGGAATACCACTTAATCTGGGCCAAAAGGAATGACCCTAGCCAGACTCAGGGATCAAAGAGCAAACAGATTCAG
TGGCCTGCATTGACTTTCAAACCTCTGGTTGAAAGAAATATACCCAGTTCAGTCACTGCAGTAGAATTCCTTGTAGATAAGCAACTGGAT
TTTTTAACTGAAGATAGTGCCTTTCAGCCCTACCAGGAAATCAGAAAAGTTGTACAGAGTTTAGAACAAACAGCTCGAGAGATTTTAACT
CTACTGCAAGGGGTCCATCAGGGTGCTGGGTTTCAGGACATTCCAAAGAGGTGTTTGAAAGCTCGAGAACATTTTGGTACAGTAAAAACA
CATCTAACATCTTTGAAGACCAAATTTCCTGCTGAACAGTATTACAGATTTCATGAGCACTGGAGGTTTGTGTTGCAGCGCTTGGTCTTC
TTGGCAGCATTTGTTGTGTATTTGGAAACAGAAACACTAGTGACTCGAGAAGCAGTTACAGAAATTCTTGGCATTGAGCCAGATCGGGAG
AAAGGATTTCATCTGGATGTAGAAGATTATCTCTCAGGAGTTCTAATTCTTGCCAGTGAACTGTCGAGGCTGTCTGTCAACAGCGTGACT
GCTGGAGACTACTCCCGACCCCTCCACATCTCCACCTTCATCAATGAGCTGGATTCCGGTTTTCGCCTTCTCAACCTGAAAAATGACTCC
CTGAGGAAGCGCTACGACGGATTGAAATATGACGTGAAGAAAGTAGAGGAAGTGGTCTATGATCTCTCCATCCGGGGCTTTAATAAGGAG
ACGGCAGCAGCTTGTGTTGAAAAATAGGAGGCTCTCCTTGCTCCTGGCCTTGCTGACCTCAGCGGTTGCCAGGAAGGGGTGAGCACAGAG
TGCCTCTTACGGTAGTTAGGATGCTCAGTTGCTAAACACTGCGCTTTATTTTCTTAACCAGTTGTGGTGTGAGTATCAGAATTGAAACAC
TTTTTTGGGGGTAAAAAATATAGCCTTTACATGGACAGAATTTTTTTTGTTGTTTCAGTGAATATGCCTGTAATTCAGTGTATTTCAGTT
CCGTCAGAAAGTGTAAATGTTAGTTTCTTGGTAAAGTCCTTTTCTTGCTTACCTTGACTGTTGATGTACTGATTGAGAAGTTCATTGTCT
CGTTTGTGATTCTTCCAGATGTGATGCTTGATATTTTCTATATGCGAGTTAGCCATCCACACCCAGGCATAGCCTGGATACAGTATAAAA
ATAGATAATTAAAAAGATGGTTGCCAAGCAAGGAAAACTTATTTTATATTTTCCCTTCCTTATTTTAAGCATTGTGAGTAAATCAGATGT
TGAATTCTTTTGCCAAGGGAATTATAGCTGCAGGTTCTCTCTCACTGCCATCAAACTGTAAAAGATTAAACTGCGAAGTCAAGCTCAACA
GATTATTTTGGAAAGTTTTTGTATTAAGGGATTTAGTAACATCATTTTGTTTTCCACCAGGCAGGGAGTAGGGCTTAGTGTTTTAAAACA
CCTCTGCTTTCTGATGTTGCCTTAATATTCTGCTATTGCAGCAATTAAAAATTGTCTTCATGTACATTTGGAACTAACACGTGATGTGAT
ATATTCCTAAACTATGAAACCTTTTTCCTAGTAGTCAGCTAGATCATTTGTTCTGGGAGTATAAAGCCACCCACGTAAGTTAATAAGCAA
AATCCTGACTATTATGTTGTTAGAGAAAAATGCTTTGCTTTGTCTGGAAGAAAGATAAAATAGTGAATTATAAATAAGTCAGGCCGGGCG
TGGTGGCTCACACCTGTAATCCCAGCACACTGGGAGGCCGAGGCAGGGGGACTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACA
AAGTGAGACTCCATCTCTATATAAAAACAAAAACCACGAAAGCACACACAAAATAAATCAGTGGGATTTGGTAATGTGTTTTAGAGTAAG
AAATTTCAGGTTGTTGGTGACTATCCCAACAGTCATGTTTTAAATGTACAGTTTGGGGCAAGTCATGTAAATACTGTTGGTGGTCTTCCC
CACACGCCCCAATTTTCAGGTAGTACTAAGAGTATGTGCCAGGAAACTCTTGCTATTGAATTGAGATGATTAAAATGGTGACTTAATCCG
TAGTTATTTTGCACCCACTGAAAGGAAAGTGCTTTCCAGAATAATATGAAGTATCTAAAAGTGTCACCTTTTCTTGCCTGATCAACAATT
TGGGCTTCCTGTTTGTACAAGGGGCCATTTGGCATACCTTTCACAGCTTTTATCAGGCCAAGTTAAAGGCTGACTACATTTTTTCATCAT
GAGGAAAGCAGTTGAAATGAGGCATGAGTTACTGTGCATTGGGATTTTAGAACAATTTTCTTGTGACAGCTCTTTTTGTGAAGTTAGGTT
CTTAAAAGTGCCCATGATGGTCACTTAAAATGTGCAGTAATAGCACTGCCAGGATCAAGCATGAAAGGCTTTTAAATTAGATCATCCCAC
AGACAATACGTTTGATAATAGTTTTTTCTTTTAACCTCTTTAAGTATTGATTCTGCTTGAGAATATTGAAGTACTTGCCAGAAGTTGTGG
ATTTCAGTTTTAACAAATGCTATTAAAGTGGAGAAGCACACTCTGGTCTTGGAATTCCATTTGAGGATTTAGAAGTGTCATGTTTATAAC
TATTCAGTTGTGTTTGTTGCTGGCTTGTTGTAAAGCAATAAAATTTTTTTGGTCTTTTTGTAAGTGAGTGTGCTGCTGTAAGAAATCTCC
CATGTGCATAACAAATTCTGAATATTTTTTGAGGCTAAAGAAGACCGGGGTGACAAGCAGATACTGCTGTGTAATGGTTACACTAACCAA
AAGACACCAGCCACTCAGAGTTCTATACTGTAAAGCGCAGATAACATTTGTGTGTTATACCTTGATTGGGGAATTAAAAGTCATTTAACT
GAAGATGTTGAGAAACCTGGGCTCTGGTTTTAGTATACCGGAATTACTTTTTTCCAATTTTAGAAAATCAAGCAGGTTAGAGAAAATAGA
GATGAATTAGGGGACACTGTCTTATGGATTCATTTATAAGAAGAGAACCAGCCATATACACTTGGGGAGATTTGCCACATCTTAAACTTG
AATAATAGTATGAGTAATGCTTAAGGGAGTTTAATAGAGAAGGAAAGCTTTGGCAGTGTTTTGAGAACTTAAGTGGCTAAAGAGATGAGA

>40985_40985_1_JMJD1C-TSN_JMJD1C_chr10_65024410_ENST00000399262_TSN_chr2_122514814_ENST00000389682_length(amino acids)=367AA_BP=161
MEEAAAASAATAMAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDF
STFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALTFKPLVERNIPSSVTAVEFLVDKQLDFLTEDSAFQPYQEIRKVVQSLEQTAREILTL
LQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREK
GFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKET

--------------------------------------------------------------
>40985_40985_2_JMJD1C-TSN_JMJD1C_chr10_65024411_ENST00000399262_TSN_chr2_122514814_ENST00000389682_length(transcript)=3773nt_BP=666nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGGTGTATGTGGAATTTGATGATCTTGAATGGGATAAACGAGAGTGGGTTAAAGTTTATGAAGAT
TTTTCAACTTTCTTGGTGGAATACCACTTAATCTGGGCCAAAAGGAATGACCCTAGCCAGACTCAGGGATCAAAGAGCAAACAGATTCAG
TGGCCTGCATTGACTTTCAAACCTCTGGTTGAAAGAAATATACCCAGTTCAGTCACTGCAGTAGAATTCCTTGTAGATAAGCAACTGGAT
TTTTTAACTGAAGATAGTGCCTTTCAGCCCTACCAGGAAATCAGAAAAGTTGTACAGAGTTTAGAACAAACAGCTCGAGAGATTTTAACT
CTACTGCAAGGGGTCCATCAGGGTGCTGGGTTTCAGGACATTCCAAAGAGGTGTTTGAAAGCTCGAGAACATTTTGGTACAGTAAAAACA
CATCTAACATCTTTGAAGACCAAATTTCCTGCTGAACAGTATTACAGATTTCATGAGCACTGGAGGTTTGTGTTGCAGCGCTTGGTCTTC
TTGGCAGCATTTGTTGTGTATTTGGAAACAGAAACACTAGTGACTCGAGAAGCAGTTACAGAAATTCTTGGCATTGAGCCAGATCGGGAG
AAAGGATTTCATCTGGATGTAGAAGATTATCTCTCAGGAGTTCTAATTCTTGCCAGTGAACTGTCGAGGCTGTCTGTCAACAGCGTGACT
GCTGGAGACTACTCCCGACCCCTCCACATCTCCACCTTCATCAATGAGCTGGATTCCGGTTTTCGCCTTCTCAACCTGAAAAATGACTCC
CTGAGGAAGCGCTACGACGGATTGAAATATGACGTGAAGAAAGTAGAGGAAGTGGTCTATGATCTCTCCATCCGGGGCTTTAATAAGGAG
ACGGCAGCAGCTTGTGTTGAAAAATAGGAGGCTCTCCTTGCTCCTGGCCTTGCTGACCTCAGCGGTTGCCAGGAAGGGGTGAGCACAGAG
TGCCTCTTACGGTAGTTAGGATGCTCAGTTGCTAAACACTGCGCTTTATTTTCTTAACCAGTTGTGGTGTGAGTATCAGAATTGAAACAC
TTTTTTGGGGGTAAAAAATATAGCCTTTACATGGACAGAATTTTTTTTGTTGTTTCAGTGAATATGCCTGTAATTCAGTGTATTTCAGTT
CCGTCAGAAAGTGTAAATGTTAGTTTCTTGGTAAAGTCCTTTTCTTGCTTACCTTGACTGTTGATGTACTGATTGAGAAGTTCATTGTCT
CGTTTGTGATTCTTCCAGATGTGATGCTTGATATTTTCTATATGCGAGTTAGCCATCCACACCCAGGCATAGCCTGGATACAGTATAAAA
ATAGATAATTAAAAAGATGGTTGCCAAGCAAGGAAAACTTATTTTATATTTTCCCTTCCTTATTTTAAGCATTGTGAGTAAATCAGATGT
TGAATTCTTTTGCCAAGGGAATTATAGCTGCAGGTTCTCTCTCACTGCCATCAAACTGTAAAAGATTAAACTGCGAAGTCAAGCTCAACA
GATTATTTTGGAAAGTTTTTGTATTAAGGGATTTAGTAACATCATTTTGTTTTCCACCAGGCAGGGAGTAGGGCTTAGTGTTTTAAAACA
CCTCTGCTTTCTGATGTTGCCTTAATATTCTGCTATTGCAGCAATTAAAAATTGTCTTCATGTACATTTGGAACTAACACGTGATGTGAT
ATATTCCTAAACTATGAAACCTTTTTCCTAGTAGTCAGCTAGATCATTTGTTCTGGGAGTATAAAGCCACCCACGTAAGTTAATAAGCAA
AATCCTGACTATTATGTTGTTAGAGAAAAATGCTTTGCTTTGTCTGGAAGAAAGATAAAATAGTGAATTATAAATAAGTCAGGCCGGGCG
TGGTGGCTCACACCTGTAATCCCAGCACACTGGGAGGCCGAGGCAGGGGGACTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACA
AAGTGAGACTCCATCTCTATATAAAAACAAAAACCACGAAAGCACACACAAAATAAATCAGTGGGATTTGGTAATGTGTTTTAGAGTAAG
AAATTTCAGGTTGTTGGTGACTATCCCAACAGTCATGTTTTAAATGTACAGTTTGGGGCAAGTCATGTAAATACTGTTGGTGGTCTTCCC
CACACGCCCCAATTTTCAGGTAGTACTAAGAGTATGTGCCAGGAAACTCTTGCTATTGAATTGAGATGATTAAAATGGTGACTTAATCCG
TAGTTATTTTGCACCCACTGAAAGGAAAGTGCTTTCCAGAATAATATGAAGTATCTAAAAGTGTCACCTTTTCTTGCCTGATCAACAATT
TGGGCTTCCTGTTTGTACAAGGGGCCATTTGGCATACCTTTCACAGCTTTTATCAGGCCAAGTTAAAGGCTGACTACATTTTTTCATCAT
GAGGAAAGCAGTTGAAATGAGGCATGAGTTACTGTGCATTGGGATTTTAGAACAATTTTCTTGTGACAGCTCTTTTTGTGAAGTTAGGTT
CTTAAAAGTGCCCATGATGGTCACTTAAAATGTGCAGTAATAGCACTGCCAGGATCAAGCATGAAAGGCTTTTAAATTAGATCATCCCAC
AGACAATACGTTTGATAATAGTTTTTTCTTTTAACCTCTTTAAGTATTGATTCTGCTTGAGAATATTGAAGTACTTGCCAGAAGTTGTGG
ATTTCAGTTTTAACAAATGCTATTAAAGTGGAGAAGCACACTCTGGTCTTGGAATTCCATTTGAGGATTTAGAAGTGTCATGTTTATAAC
TATTCAGTTGTGTTTGTTGCTGGCTTGTTGTAAAGCAATAAAATTTTTTTGGTCTTTTTGTAAGTGAGTGTGCTGCTGTAAGAAATCTCC
CATGTGCATAACAAATTCTGAATATTTTTTGAGGCTAAAGAAGACCGGGGTGACAAGCAGATACTGCTGTGTAATGGTTACACTAACCAA
AAGACACCAGCCACTCAGAGTTCTATACTGTAAAGCGCAGATAACATTTGTGTGTTATACCTTGATTGGGGAATTAAAAGTCATTTAACT
GAAGATGTTGAGAAACCTGGGCTCTGGTTTTAGTATACCGGAATTACTTTTTTCCAATTTTAGAAAATCAAGCAGGTTAGAGAAAATAGA
GATGAATTAGGGGACACTGTCTTATGGATTCATTTATAAGAAGAGAACCAGCCATATACACTTGGGGAGATTTGCCACATCTTAAACTTG
AATAATAGTATGAGTAATGCTTAAGGGAGTTTAATAGAGAAGGAAAGCTTTGGCAGTGTTTTGAGAACTTAAGTGGCTAAAGAGATGAGA

>40985_40985_2_JMJD1C-TSN_JMJD1C_chr10_65024411_ENST00000399262_TSN_chr2_122514814_ENST00000389682_length(amino acids)=367AA_BP=161
MEEAAAASAATAMAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDF
STFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALTFKPLVERNIPSSVTAVEFLVDKQLDFLTEDSAFQPYQEIRKVVQSLEQTAREILTL
LQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREK
GFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKET

--------------------------------------------------------------
>40985_40985_3_JMJD1C-TSN_JMJD1C_chr10_65140077_ENST00000399262_TSN_chr2_122514815_ENST00000389682_length(transcript)=3659nt_BP=552nt
CACAAGGCTGCGAATCTGGGAGTCCAAAGGAGTGTTTGCGGGGAGGGCCCGAGGTCGCTGTGTCCGGGGCAGAGCGGCCGGTTCGTCCCG
AGTCTGCGCTCTTTCGGGTCCGCTGCTGTGTCCCGGTCCGCTCTCCTCAGCATGAGCGGCCGGTAGGAGTGAGGTTTCATCGGTTCCCTC
GCACTGGAGGAGGCAGCGGCCGCTTCGGCAGCGACAGCTATGGCGGTAGAGACGCGGGCAGAGCTGGTGGGTAAGCGGTTCCTGTGTGTG
GCGGTCGGCGACGAGGCACGTTCGGAGCGCTGGGAGAGCGGACGCGGCTGGCGAAGCTGGCGAGCGGGGGTCATCCGAGCCGTGTCACAC
AGGGACAGCCGCAATCCGGACCTGGCGGTGTATGTGGAATTTGATGATCTTGAATGGGATAAACGAGAGTGGGTTAAAGTTTATGAAGAT
TTTTCAACTTTCTTGGTGGAATACCACTTAATCTGGGCCAAAAGGAATGACCCTAGCCAGACTCAGGGATCAAAGAGCAAACAGATTCAG
TGGCCTGCATTGGAAATCAGAAAAGTTGTACAGAGTTTAGAACAAACAGCTCGAGAGATTTTAACTCTACTGCAAGGGGTCCATCAGGGT
GCTGGGTTTCAGGACATTCCAAAGAGGTGTTTGAAAGCTCGAGAACATTTTGGTACAGTAAAAACACATCTAACATCTTTGAAGACCAAA
TTTCCTGCTGAACAGTATTACAGATTTCATGAGCACTGGAGGTTTGTGTTGCAGCGCTTGGTCTTCTTGGCAGCATTTGTTGTGTATTTG
GAAACAGAAACACTAGTGACTCGAGAAGCAGTTACAGAAATTCTTGGCATTGAGCCAGATCGGGAGAAAGGATTTCATCTGGATGTAGAA
GATTATCTCTCAGGAGTTCTAATTCTTGCCAGTGAACTGTCGAGGCTGTCTGTCAACAGCGTGACTGCTGGAGACTACTCCCGACCCCTC
CACATCTCCACCTTCATCAATGAGCTGGATTCCGGTTTTCGCCTTCTCAACCTGAAAAATGACTCCCTGAGGAAGCGCTACGACGGATTG
AAATATGACGTGAAGAAAGTAGAGGAAGTGGTCTATGATCTCTCCATCCGGGGCTTTAATAAGGAGACGGCAGCAGCTTGTGTTGAAAAA
TAGGAGGCTCTCCTTGCTCCTGGCCTTGCTGACCTCAGCGGTTGCCAGGAAGGGGTGAGCACAGAGTGCCTCTTACGGTAGTTAGGATGC
TCAGTTGCTAAACACTGCGCTTTATTTTCTTAACCAGTTGTGGTGTGAGTATCAGAATTGAAACACTTTTTTGGGGGTAAAAAATATAGC
CTTTACATGGACAGAATTTTTTTTGTTGTTTCAGTGAATATGCCTGTAATTCAGTGTATTTCAGTTCCGTCAGAAAGTGTAAATGTTAGT
TTCTTGGTAAAGTCCTTTTCTTGCTTACCTTGACTGTTGATGTACTGATTGAGAAGTTCATTGTCTCGTTTGTGATTCTTCCAGATGTGA
TGCTTGATATTTTCTATATGCGAGTTAGCCATCCACACCCAGGCATAGCCTGGATACAGTATAAAAATAGATAATTAAAAAGATGGTTGC
CAAGCAAGGAAAACTTATTTTATATTTTCCCTTCCTTATTTTAAGCATTGTGAGTAAATCAGATGTTGAATTCTTTTGCCAAGGGAATTA
TAGCTGCAGGTTCTCTCTCACTGCCATCAAACTGTAAAAGATTAAACTGCGAAGTCAAGCTCAACAGATTATTTTGGAAAGTTTTTGTAT
TAAGGGATTTAGTAACATCATTTTGTTTTCCACCAGGCAGGGAGTAGGGCTTAGTGTTTTAAAACACCTCTGCTTTCTGATGTTGCCTTA
ATATTCTGCTATTGCAGCAATTAAAAATTGTCTTCATGTACATTTGGAACTAACACGTGATGTGATATATTCCTAAACTATGAAACCTTT
TTCCTAGTAGTCAGCTAGATCATTTGTTCTGGGAGTATAAAGCCACCCACGTAAGTTAATAAGCAAAATCCTGACTATTATGTTGTTAGA
GAAAAATGCTTTGCTTTGTCTGGAAGAAAGATAAAATAGTGAATTATAAATAAGTCAGGCCGGGCGTGGTGGCTCACACCTGTAATCCCA
GCACACTGGGAGGCCGAGGCAGGGGGACTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACAAAGTGAGACTCCATCTCTATATAA
AAACAAAAACCACGAAAGCACACACAAAATAAATCAGTGGGATTTGGTAATGTGTTTTAGAGTAAGAAATTTCAGGTTGTTGGTGACTAT
CCCAACAGTCATGTTTTAAATGTACAGTTTGGGGCAAGTCATGTAAATACTGTTGGTGGTCTTCCCCACACGCCCCAATTTTCAGGTAGT
ACTAAGAGTATGTGCCAGGAAACTCTTGCTATTGAATTGAGATGATTAAAATGGTGACTTAATCCGTAGTTATTTTGCACCCACTGAAAG
GAAAGTGCTTTCCAGAATAATATGAAGTATCTAAAAGTGTCACCTTTTCTTGCCTGATCAACAATTTGGGCTTCCTGTTTGTACAAGGGG
CCATTTGGCATACCTTTCACAGCTTTTATCAGGCCAAGTTAAAGGCTGACTACATTTTTTCATCATGAGGAAAGCAGTTGAAATGAGGCA
TGAGTTACTGTGCATTGGGATTTTAGAACAATTTTCTTGTGACAGCTCTTTTTGTGAAGTTAGGTTCTTAAAAGTGCCCATGATGGTCAC
TTAAAATGTGCAGTAATAGCACTGCCAGGATCAAGCATGAAAGGCTTTTAAATTAGATCATCCCACAGACAATACGTTTGATAATAGTTT
TTTCTTTTAACCTCTTTAAGTATTGATTCTGCTTGAGAATATTGAAGTACTTGCCAGAAGTTGTGGATTTCAGTTTTAACAAATGCTATT
AAAGTGGAGAAGCACACTCTGGTCTTGGAATTCCATTTGAGGATTTAGAAGTGTCATGTTTATAACTATTCAGTTGTGTTTGTTGCTGGC
TTGTTGTAAAGCAATAAAATTTTTTTGGTCTTTTTGTAAGTGAGTGTGCTGCTGTAAGAAATCTCCCATGTGCATAACAAATTCTGAATA
TTTTTTGAGGCTAAAGAAGACCGGGGTGACAAGCAGATACTGCTGTGTAATGGTTACACTAACCAAAAGACACCAGCCACTCAGAGTTCT
ATACTGTAAAGCGCAGATAACATTTGTGTGTTATACCTTGATTGGGGAATTAAAAGTCATTTAACTGAAGATGTTGAGAAACCTGGGCTC
TGGTTTTAGTATACCGGAATTACTTTTTTCCAATTTTAGAAAATCAAGCAGGTTAGAGAAAATAGAGATGAATTAGGGGACACTGTCTTA
TGGATTCATTTATAAGAAGAGAACCAGCCATATACACTTGGGGAGATTTGCCACATCTTAAACTTGAATAATAGTATGAGTAATGCTTAA
GGGAGTTTAATAGAGAAGGAAAGCTTTGGCAGTGTTTTGAGAACTTAAGTGGCTAAAGAGATGAGACAAACATGCAGGTCGCTACTGGCA

>40985_40985_3_JMJD1C-TSN_JMJD1C_chr10_65140077_ENST00000399262_TSN_chr2_122514815_ENST00000389682_length(amino acids)=329AA_BP=123
MEEAAAASAATAMAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDF
STFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKF
PAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for JMJD1C-TSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for JMJD1C-TSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for JMJD1C-TSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource