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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KANK1-MCTS1 (FusionGDB2 ID:41102) |
Fusion Gene Summary for KANK1-MCTS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KANK1-MCTS1 | Fusion gene ID: 41102 | Hgene | Tgene | Gene symbol | KANK1 | MCTS1 | Gene ID | 23189 | 28985 |
| Gene name | KN motif and ankyrin repeat domains 1 | MCTS1 re-initiation and release factor | |
| Synonyms | ANKRD15|CPSQ2|KANK | MCT-1|MCT1 | |
| Cytomap | 9p24.3 | Xq24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | KN motif and ankyrin repeat domain-containing protein 1ankyrin repeat domain-containing protein 15kidney ankyrin repeat-containing protein | malignant T-cell-amplified sequence 1malignant T-cell amplified sequence 1multiple copies T-cell malignanciesmultiple copies in T-cell lymphoma-1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q14678 | Q9ULC4 | |
| Ensembl transtripts involved in fusion gene | ENST00000382293, ENST00000382297, ENST00000382303, ENST00000489369, | ENST00000371315, ENST00000371317, ENST00000487133, | |
| Fusion gene scores | * DoF score | 16 X 13 X 10=2080 | 2 X 2 X 1=4 |
| # samples | 23 | 2 | |
| ** MAII score | log2(23/2080*10)=-3.17687776208408 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: KANK1 [Title/Abstract] AND MCTS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KANK1(517470)-MCTS1(119742094), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KANK1 | GO:0010977 | negative regulation of neuron projection development | 19171758 |
| Hgene | KANK1 | GO:0030177 | positive regulation of Wnt signaling pathway | 16968744 |
| Hgene | KANK1 | GO:0030837 | negative regulation of actin filament polymerization | 17996375|18458160 |
| Hgene | KANK1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 19171758 |
| Hgene | KANK1 | GO:1900028 | negative regulation of ruffle assembly | 19171758 |
| Hgene | KANK1 | GO:2000393 | negative regulation of lamellipodium morphogenesis | 19171758 |
| Tgene | MCTS1 | GO:0001731 | formation of translation preinitiation complex | 20713520 |
| Tgene | MCTS1 | GO:0032790 | ribosome disassembly | 20713520 |
| Tgene | MCTS1 | GO:0075522 | IRES-dependent viral translational initiation | 20713520 |
| Fusion gene breakpoints across KANK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MCTS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | EC556167 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
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Fusion Gene ORF analysis for KANK1-MCTS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000382293 | ENST00000371315 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000382293 | ENST00000371317 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000382297 | ENST00000371315 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000382297 | ENST00000371317 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000382303 | ENST00000371315 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000382303 | ENST00000371317 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000489369 | ENST00000371315 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3CDS | ENST00000489369 | ENST00000371317 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3UTR | ENST00000382293 | ENST00000487133 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3UTR | ENST00000382297 | ENST00000487133 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3UTR | ENST00000382303 | ENST00000487133 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| intron-3UTR | ENST00000489369 | ENST00000487133 | KANK1 | chr9 | 517470 | - | MCTS1 | chrX | 119742094 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KANK1-MCTS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KANK1-MCTS1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:517470/:119742094) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KANK1 | MCTS1 |
| FUNCTION: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:25961457}. | FUNCTION: Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:10440924, ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:12637315, ECO:0000269|PubMed:15897892, ECO:0000269|PubMed:16322206, ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17016429, ECO:0000269|PubMed:17416211, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:9766643}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KANK1-MCTS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for KANK1-MCTS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KANK1-MCTS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KANK1-MCTS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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