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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KANSL1-PARD3B (FusionGDB2 ID:41148)

Fusion Gene Summary for KANSL1-PARD3B

check button Fusion gene summary
Fusion gene informationFusion gene name: KANSL1-PARD3B
Fusion gene ID: 41148
HgeneTgene
Gene symbol

KANSL1

PARD3B

Gene ID

284058

117583

Gene nameKAT8 regulatory NSL complex subunit 1par-3 family cell polarity regulator beta
SynonymsCENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1ALS2CR19|PAR3B|PAR3L|PAR3beta
Cytomap

17q21.31

2q33.3

Type of geneprotein-codingprotein-coding
DescriptionKAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homologpartitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog Bpartitioning
Modification date2020032720200313
UniProtAcc

Q7Z3B3

.
Ensembl transtripts involved in fusion geneENST00000262419, ENST00000432791, 
ENST00000572904, ENST00000574590, 
ENST00000575318, ENST00000393476, 
ENST00000576248, 		ENST00000349953, 
ENST00000351153, ENST00000358768, 
ENST00000462231, ENST00000488622, 
ENST00000406610, 
Fusion gene scores* DoF score34 X 33 X 14=1570817 X 20 X 10=3400
# samples 4723
** MAII scorelog2(47/15708*10)=-5.0626949361014
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3400*10)=-3.88582898008069
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KANSL1 [Title/Abstract] AND PARD3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKANSL1(44159807)-PARD3B(206265737), # samples:1
Anticipated loss of major functional domain due to fusion event.KANSL1-PARD3B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KANSL1-PARD3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKANSL1

GO:0043981

histone H4-K5 acetylation

20018852

HgeneKANSL1

GO:0043982

histone H4-K8 acetylation

20018852

HgeneKANSL1

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across KANSL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARD3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5GH-01AKANSL1chr17

44159807

-PARD3Bchr2

206265737

+


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Fusion Gene ORF analysis for KANSL1-PARD3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262419ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000262419ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000262419ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000262419ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000262419ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000432791ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000432791ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000432791ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000432791ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000432791ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000572904ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000572904ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000572904ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000572904ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000572904ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000574590ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000574590ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000574590ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000574590ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000574590ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000575318ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000575318ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000575318ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000575318ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5CDS-intronENST00000575318ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-3CDSENST00000393476ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-intronENST00000393476ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-intronENST00000393476ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-intronENST00000393476ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-intronENST00000393476ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
5UTR-intronENST00000393476ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
Frame-shiftENST00000262419ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
Frame-shiftENST00000432791ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
Frame-shiftENST00000574590ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
Frame-shiftENST00000575318ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
In-frameENST00000572904ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-3CDSENST00000576248ENST00000406610KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-intronENST00000576248ENST00000349953KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-intronENST00000576248ENST00000351153KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-intronENST00000576248ENST00000358768KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-intronENST00000576248ENST00000462231KANSL1chr17

44159807

-PARD3Bchr2

206265737

+
intron-intronENST00000576248ENST00000488622KANSL1chr17

44159807

-PARD3Bchr2

206265737

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572904KANSL1chr1744159807-ENST00000406610PARD3Bchr2206265737+704317061731729518

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572904ENST00000406610KANSL1chr1744159807-PARD3Bchr2206265737+0.0018378370.9981622

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Fusion Genomic Features for KANSL1-PARD3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KANSL1chr1744159806-PARD3Bchr2206265736+0.0002785080.99972147
KANSL1chr1744159806-PARD3Bchr2206265736+0.0002785080.99972147

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KANSL1-PARD3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:44159807/chr2:206265737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KANSL1

Q7Z3B3

.
FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKANSL1chr17:44159807chr2:206265737ENST00000262419-415283_3145111106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44159807chr2:206265737ENST00000432791-314283_3145111106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44159807chr2:206265737ENST00000572904-415283_3145111106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44159807chr2:206265737ENST00000574590-415283_3145111106.0Coiled coilOntology_term=ECO:0000255
TgenePARD3Bchr17:44159807chr2:206265737ENST0000034995317221144_11498761105.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr17:44159807chr2:206265737ENST0000035876816221144_11498141144.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr17:44159807chr2:206265737ENST000003587681622830_8968141144.0Compositional biasNote=Lys-rich
TgenePARD3Bchr17:44159807chr2:206265737ENST0000040661017231144_11498761206.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKANSL1chr17:44159807chr2:206265737ENST00000262419-415850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44159807chr2:206265737ENST00000432791-314850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44159807chr2:206265737ENST00000572904-415850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44159807chr2:206265737ENST00000574590-415850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
TgenePARD3Bchr17:44159807chr2:206265737ENST000003499531722830_8968761105.0Compositional biasNote=Lys-rich
TgenePARD3Bchr17:44159807chr2:206265737ENST000004066101723830_8968761206.0Compositional biasNote=Lys-rich
TgenePARD3Bchr17:44159807chr2:206265737ENST000003499531722201_2898761105.0DomainPDZ 1
TgenePARD3Bchr17:44159807chr2:206265737ENST000003499531722383_4688761105.0DomainPDZ 2
TgenePARD3Bchr17:44159807chr2:206265737ENST000003499531722498_5858761105.0DomainPDZ 3
TgenePARD3Bchr17:44159807chr2:206265737ENST000003587681622201_2898141144.0DomainPDZ 1
TgenePARD3Bchr17:44159807chr2:206265737ENST000003587681622383_4688141144.0DomainPDZ 2
TgenePARD3Bchr17:44159807chr2:206265737ENST000003587681622498_5858141144.0DomainPDZ 3
TgenePARD3Bchr17:44159807chr2:206265737ENST000004066101723201_2898761206.0DomainPDZ 1
TgenePARD3Bchr17:44159807chr2:206265737ENST000004066101723383_4688761206.0DomainPDZ 2
TgenePARD3Bchr17:44159807chr2:206265737ENST000004066101723498_5858761206.0DomainPDZ 3


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Fusion Gene Sequence for KANSL1-PARD3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41148_41148_1_KANSL1-PARD3B_KANSL1_chr17_44159807_ENST00000572904_PARD3B_chr2_206265737_ENST00000406610_length(transcript)=7043nt_BP=1706nt
CGGCGCCCAGGCCGGGGGGCTGTTTGCAAACTGCGCCCATTTTGTGGGGCTGAATCCGCCCGGGCTACGCTCCTCCATCACGTGTCTGTT
CTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTG
CGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCA
GTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATT
TCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAA
AGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTG
AGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCAC
CTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTC
TCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATA
GAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTC
AAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCA
TTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAA
AGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGC
CAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCA
CTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGT
GCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATC
CCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCTTC
AGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATACGTGCTAATAAGGGGTTGATAGTTCTTG
GGGAGGTACCTCCCCCAGAGCATACAACAGACTTATTTCTTCCACTTAGTTCTGAGGTGAAGACAGATCATGGGACTGATAAATTGATTT
GGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATG
AAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAATT
GGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTTTCGGGAACCATGCACATCAGCAAATGTC
TTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGGGT
CTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAG
TTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTA
CTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGA
GGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCT
ATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCT
CCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCA
GGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGAACCCCATGACTGCAGCCGTATAGCTGAGT
GCCACCGAGGCCAGCCCGGTCCAGAAAGGAAGGTGTCTACTCTACCTTTGCCCTTTCTAAACCTGAAGACCTCCTTGGTGTTAGGAATTC
TCCATGTTACTGATAAGCTTTTTCTCACTGACATTGTAACGCATGACTGCTAATCAGAGAGAAAAAGAAGGGGAAGGGAATTGGGGAGGA
AAAAAAATCAGAAGGAAGACGAAAGATGGGGCTATAAAAACAAAACTACCTGATAGTTGAAACGCTTTCAGAGTTGTTCAAATCAGTGAG
AGTGGCAACGGAACACACAAACAACTAATTATGGAACTCTACTCTGGGGATCCTCTCTGGCTAGATAACCTGTGCTGATGTGCAGACACG
TGGACATCCCCCTCTGAGACTGGCGGTCCAGAGGCAGTCTCTGCCAGGCAGCATTACCCGCTCCGAGGTGGAGCCTCAGCCCCCTTCTTA
GAGCTGTTAAGTCTAAGGTGTGGCAGAGCAGACAGAGATAGAGGCATCTGAAGTGAGTATAGGTTTTTTGACTAAGAAAAAAAACAACAG
CAAACATGACTAGTGATCTTGAAATATTTTGTACCGAGAGAAAGACTGCATTTATTTGTAGAATTTATCAGGTTTCTGATACCACTCATT
GGATGTAAACATTTCATGTTTCCTCACTTTTGATATGAAAGTCGGTAAAATGCAGTATTAGTCCCGGGAGGATGTGCACAGCTGGTCAGA
GCTTCCAGAAGGAATATCTTCCGAGGACTAAGGTGATCAGGTTAAGAGGGTTCAACATCCCACGGCCCTCACCTTCCTCCCTCCCACATT
CCAGGCATGGAGATATCTGGTTTCAGAGTCAGCCCCAAATCTCCTGCCTATAATTACTTTAACTGGGGTCTCTAAGGTTCCCACTTGAGG
GCTAAAATGTAGTTGGGAAAGAGGGCCTACTGGGGAGGTCTCACAGGAGGCAGTGCCCTGGGAAATGCCAAGTCCAGACTCAGTGCCAAG
CAGTAACCATCTGCACTCGGGGACAGCGAGGAGCTGACCATGGCCTCTGATGACCAGCAGGTATTAGATGGAAGTGAATGAGAGAGAGAG
AGAGAGAGAGTATGTGTGTGTGTGTGTATGTGTGTGTTCGAACACATATGATTGCCAGTATGGAGAATGAAAGATTAATAATGCTTTCTG
GAGAGTTTGATGCAAAAGTGGGGGAAACGGAGAAAAGGCGCTAAGGCTAAATCCATCTGCATTTGCTATATTTCATTAGCTAAAGTCAGG
TCAGGGCAGGGCCAAGGCCTCCAATTGGCAAAGGACAGTGTTATGGCTTTAAAAAGCTGAAACCCCAACCTCTAAGTAGATCACAATGTT
TTCTGAGCTTTGCAGTAATTTTCTATGGAAACTAAAACCTCTAAAACATACAAGCTGGCCCAAATGAGAACACAAGCAAAAGATGTGGAA
GACAGCAAAACCTGAGCACTGGTTTGAACCAGGCACTGACATTTGAAATGCTTTAAGCCTTTTCACATTCCTTCTTTATTCCCTCCAAAA
AAAAAAGTCTTGAGTTTAATTTAGGTCTATTTTGGCTGAGATTAGCATACCTCTGACTCACAGGATTTAATAAATTATAGTATTATTGAA
TACATAGGACATCCCTCTACCCCAGCTTACTCTTATCTTTTTAATTTAAAATAGTATTCTGCTACCAAGAAGGATGCAACTGCTAGTTTT
AGATGTAAATAGTGTTATTTACTGGACTTTGTGATATTATTTTCTTAACTACACTTTACTATGGCCCTGTTGAAAACAGACTATCAAGTT
TTTTGTCTCTGTTCTGTCATCTCTCTTAAGCCAGGCACCTTTAGAGTGTTTGCAATTTGTTCGAAGTGGTTGAGGATCTCAGGCCCTGCT
CACGTGAGGTGGAGTGCAGGGGAGCTACCGGTTTCCCTGCTGACCTGCTGAATGCTACCTTCCCCTCGAGTTGAATACACCTTAAGGAAA
ATGATAACACGAGGGACGTGTAACTTGTTTTGAAGCATTAAAAACCAGCAGCTCTTCACTATGTTCCATATTTTAACCAAACTACTGTAG
ACTACTAAACATAGCCAAGCCAGAACATTCCTTCTGGATTAAGCCTAGGCCACTTGAGGGGCAGCCAGGGGTGATGGTGTCAGGTGAGAA
TCCTGTGTCTTGAAGGAGTGGCCTTTACAGGAAGAGTGCCCATGTTTTCACCTGCAGCGTTGCCACCAGAGTGTGCAATACCTCCTGCAC
ACAGGCTCAGGGTAAACTGCTCCAAAGCTGGGTTTTGTGTTGCATACAAAGTCAATAAAATAGTTGCTAATCCTGAATGGCAGCCAGTGA
TGTGAAGGTACTATTAAAGTGAACAAAAACTAGATTGCAACAGTTTTCTTTCCTTGCTTGAAGTATAACACACGCTCCATTTGATCCTGC
CTGAAAGAAGCTAACATTATATTTGTGACAGACAGAGGCTCCATCAAGCCAAGCAACAATTAACAGCTCAAGTGTAAGATTTATAAATGC
CCGTGTACTCACCCTTCAATTGTTACCACCCAGAGGTTACAGGACTCTTTCCCAGCATTTAGGGGAACAGGCTTTTAGAGTATTTAGAAG
ACCAGGCTATAATCAGTAATGTGCCTGGGAGCAGGAAATAGCTCCCAATTTATTTATGGCCTTGGGAAAACTCAATCCGGTGTCTCCTTG
TAGCTCAGAACACTAATAGCCCCCCTGGAAGAGAGTGGCACATTGAGCTCCAAACCCAATCAACATACATCCACTTGGCTGCAGATCTGA
CTGCTGGGTCATGAAGGCCGTGAAATGATGTTTGCCCTCAAGTCACTAGATATTTTAAGAAGCCCTATTTTTCTCCCTTTTTGCAGGAGT
AGAGAGATGAAAGAGGACAGACCATTGAAAACTTTTAGATGCAGGAGAATTGAGACTTCCACAAGGGAGAGAAACACAGCCTCCCCAGAA
TCCATTATGCCATCGGGTTGTGGCACTCTCACCCTTGCCATAATACCGTTTCCTAACAATATCAAATCAGTGGATGAAATACAAGCTCAG
AAACAGGAACATTTTCCTAAATCATAACCTAATAGCAAACAAAAATTGAAAAAACAATTATTCTGAAGCTCATTATTCTTAGATCTGTAG
ATATATATGTGTTGACTCCCACAGGATGGCACCAAGTAAAGATCTTAAGAGCATAGTAGGGGTTCTGAGACCGACTGTCACCCGTGGATC
CTGATGGGGAAGAACAGAGGCTTCACTGTAGCTATAGTTTTCCACCAAGTCAATCAAATTAAAACATGACTCATTGTCCCCTCCAAAGAT
TCATAAAATTCTTGAGCTAAAGTGATCTTCTGAAGAAAAGCCACCTAACAATGTTAGGAGGCTCATAAAGCTCATTTCTCTTTTCCCTGG
TATGCACAAATATCAAGCCTATAAAAAAGTAATTATTTCCCCAAACCTGTAACCACTGCATTCGTTTTCTTTGGAGGAACATTGTAGCAT
TTCAGGAGGGTCGAGAGATCTAAAGAGTTTGGTCTGAATGTGTGTCTGTACAATTCCCTTTGGCATTAAACTCTGAAACCTACAATCAAT
GGCCTTCAAATTGGTGTTAAATTGGGAGAACACCCTACTGCTTTCTGAGTCTACGAGCAACAGAAAGACTGGTCTTAGTGCAATTAGGCA
GGAGGGATTTGGACTCAGAAACAGCCACAGAAGTATTTCTCAGCACTCCCAGTTCCTGCCAACTTAGCTGGAAACGATGCCACAGCGAGA
CCAGAAAGAGGAGTCGCCTTAAGGTATCCCTACAAAGTCACCTTTCTGATAAAAAGGAGGGAAAAAAAAGTTAGATATCTAAAATAAGCC
TAGAATCTCACACACAGCTGTGACTTCTAAGTGAAACTCTTTTCTCCCTCATGTCCTTAAATAGTCACAGAATCACACACAGCCTGACTT
TTAAAGACAAGCTTGGCTACAGGAAATGAACCAACCCCAAAGACTCTTCTAACCTGTCTCCTGACTGGGCTCCTTCAGAAAGTGTTCTCC
TGTTCCATCTGTAGGGCTGCTTACTACTGGAACCTAAAACAAAACCTGTTGTTTGTACCATCACTTTTTCTGGTGTTTCCTGTGCTTTTG
TGATTCCAAGTCTGTTCATAAGTTCTGAAGATAAATTATGTGAAATCATATTTTGGCATATGGGGGTGGAGGATGAATTCTTTACAGACT
TTTTAAGATGATCCATTTGTACCACAGAAAACATTTTGGAAGTTGTTATATATGAGTATATAAATTTTTCTTTTCATATTTTACATTAAA

>41148_41148_1_KANSL1-PARD3B_KANSL1_chr17_44159807_ENST00000572904_PARD3B_chr2_206265737_ENST00000406610_length(amino acids)=518AA_BP=
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN

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Fusion Gene PPI Analysis for KANSL1-PARD3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KANSL1-PARD3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KANSL1-PARD3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource