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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KANSL1-PHF20 (FusionGDB2 ID:41149)

Fusion Gene Summary for KANSL1-PHF20

Fusion gene summary

Fusion gene information	Fusion gene name: KANSL1-PHF20
	Fusion gene ID: 41149
		Hgene	Tgene
	Gene symbol	KANSL1	PHF20
	Gene ID	284058	51230
	Gene name	KAT8 regulatory NSL complex subunit 1	PHD finger protein 20
	Synonyms	CENP-36\|KDVS\|KIAA1267\|MSL1v1\|NSL1\|hMSL1v1	C20orf104\|GLEA2\|HCA58\|NZF\|TDRD20A\|TZP
	Cytomap	17q21.31	20q11.22-q11.23
	Type of gene	protein-coding	protein-coding
	Description	KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog	PHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20A
	Modification date	20200327	20200313
	UniProtAcc	Q7Z3B3	.
	Ensembl transtripts involved in fusion gene	ENST00000262419, ENST00000432791, ENST00000572904, ENST00000574590, ENST00000575318, ENST00000393476, ENST00000576248,	ENST00000439301, ENST00000481202, ENST00000374012,
Fusion gene scores	* DoF score	34 X 33 X 14=15708	26 X 25 X 15=9750
	# samples	47	32
	** MAII score	log2(47/15708*10)=-5.0626949361014 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/9750*10)=-4.92925840863697 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KANSL1 [Title/Abstract] AND PHF20 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KANSL1(44171925)-PHF20(34515701), # samples:1
Anticipated loss of major functional domain due to fusion event.	KANSL1-PHF20 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KANSL1	GO:0043981	histone H4-K5 acetylation	20018852
Hgene	KANSL1	GO:0043982	histone H4-K8 acetylation	20018852
Hgene	KANSL1	GO:0043984	histone H4-K16 acetylation	20018852
Tgene	PHF20	GO:0043981	histone H4-K5 acetylation	20018852
Tgene	PHF20	GO:0043982	histone H4-K8 acetylation	20018852
Tgene	PHF20	GO:0043984	histone H4-K16 acetylation	20018852

Fusion gene breakpoints across KANSL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PHF20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25F	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+

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Fusion Gene ORF analysis for KANSL1-PHF20

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000262419	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-3UTR	ENST00000432791	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-3UTR	ENST00000572904	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-3UTR	ENST00000574590	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-3UTR	ENST00000575318	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-intron	ENST00000262419	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-intron	ENST00000432791	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-intron	ENST00000572904	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-intron	ENST00000574590	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5CDS-intron	ENST00000575318	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5UTR-3CDS	ENST00000393476	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5UTR-3UTR	ENST00000393476	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
5UTR-intron	ENST00000393476	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
Frame-shift	ENST00000262419	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
Frame-shift	ENST00000572904	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
In-frame	ENST00000432791	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
In-frame	ENST00000574590	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
In-frame	ENST00000575318	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
intron-3CDS	ENST00000576248	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
intron-3UTR	ENST00000576248	ENST00000439301	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+
intron-intron	ENST00000576248	ENST00000481202	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000574590	KANSL1	chr17	44171925	-	ENST00000374012	PHF20	chr20	34515701	+	5447	1658	227	2692	821
ENST00000575318	KANSL1	chr17	44171925	-	ENST00000374012	PHF20	chr20	34515701	+	5254	1465	34	2499	821
ENST00000432791	KANSL1	chr17	44171925	-	ENST00000374012	PHF20	chr20	34515701	+	5305	1516	85	2550	821

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000574590	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+	0.00140626	0.99859375
ENST00000575318	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+	0.00151366	0.9984863
ENST00000432791	ENST00000374012	KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+	0.001562568	0.99843746

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Fusion Genomic Features for KANSL1-PHF20

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+	0.000783191	0.9992168
KANSL1	chr17	44171925	-	PHF20	chr20	34515701	+	0.000783191	0.9992168

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KANSL1-PHF20

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:44171925/chr20:34515701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KANSL1 Q7Z3B3	.
FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:22547026}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000262419

283_314

477

1106.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000432791

283_314

477

1106.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000572904

283_314

477

1106.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000574590

283_314

477

1106.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

654_700

646

1356.0

Zinc finger

Note=PHD-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000262419

850_882

477

1106.0

Region

Note=Required for activation of KAT8 histone acetyltransferase activity

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000432791

850_882

477

1106.0

Region

Note=Required for activation of KAT8 histone acetyltransferase activity

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000572904

850_882

477

1106.0

Region

Note=Required for activation of KAT8 histone acetyltransferase activity

Hgene

KANSL1

chr17:44171925

chr20:34515701

ENST00000574590

850_882

477

1106.0

Region

Note=Required for activation of KAT8 histone acetyltransferase activity

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

162_221

668

1013.0

Compositional bias

Note=Lys-rich

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

523_552

668

1013.0

Compositional bias

Note=Lys-rich

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

162_221

646

1356.0

Compositional bias

Note=Lys-rich

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

523_552

646

1356.0

Compositional bias

Note=Lys-rich

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

257_269

668

1013.0

DNA binding

Note=A.T hook

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

257_269

646

1356.0

DNA binding

Note=A.T hook

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

4_69

668

1013.0

Domain

Note=Tudor 1

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

83_147

668

1013.0

Domain

Note=Tudor 2

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

4_69

646

1356.0

Domain

Note=Tudor 1

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

83_147

646

1356.0

Domain

Note=Tudor 2

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

452_477

668

1013.0

Zinc finger

C2H2-type

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000374012

654_700

668

1013.0

Zinc finger

Note=PHD-type

Tgene

PHF20

chr17:44171925

chr20:34515701

ENST00000439301

452_477

646

1356.0

Zinc finger

C2H2-type

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Fusion Gene Sequence for KANSL1-PHF20

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41149_41149_1_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000432791_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5305nt_BP=1516nt
TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC
TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG
CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA
TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC
AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC
TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC
ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC
TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA
TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT
TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC
CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA
AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT
GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC
CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG
GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA
TCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCT
TCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCA
GTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCA
GAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCA
TCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGAT
GAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAG
AAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGC
CCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCA
GAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCT
GGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGC
CCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCT
GACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTA
CACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGT
GCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCG
CATATTTAAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGAC
AAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGT
GCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTT
AGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCT
GGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAG
CAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTT
GTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAA
TAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCT
TCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAA
TTACCTTATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTT
CAGAATTGTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCA
GGTACAACCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTT
TTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAA
AGCACAGTTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGA
AGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGC
CTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTG
ATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACT
GCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATG
CAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCT
TTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGC
AGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCAT
TGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGC
TCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAA
ATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGA
GTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCT
CAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCT
CGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAA
AACTATCCACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGT
GGATCCTTGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCT

>41149_41149_1_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000432791_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=821AA_BP=477
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY
SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP
LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK
KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG

--------------------------------------------------------------
>41149_41149_2_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000574590_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5447nt_BP=1658nt
TCAGATACCTTCTCGAAACAAAAGATTTTCCTACCTGCTTATACTTGGTAACCGAGGGAATTACTAAGACTTCTTGCTCATTTCTGAGTA
TTGTCTTTATATCCTGACACTATGAATGCTACTTGGATGCCTCTTAAGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCT
CGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAG
CACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTG
CTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGC
TGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGC
AGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCT
TAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTT
CAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAG
GATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCA
ATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCA
GCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAA
CAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGA
GGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGA
TGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATT
CAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACA
GTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAG
AATGGAAATGGGCTGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTC
AGCAAACAGACATTTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCAGTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAG
AAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGC
TGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTC
TTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGC
TGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAG
CTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCA
CCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACG
ATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACA
GTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACA
GAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACA
GGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGC
TTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGG
CACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAATAAATAAACCTAGCATGCTGAATGCACG
TGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCT
CGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACT
TCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTT
AATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTC
TAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTT
CACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTT
TGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGG
GTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAA
TTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATTTTATATTGTTGTAAACAAACTTCAAATT
CTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTTTTGTTACTATACTTTAACATTTTACATT
TCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCTATTTGTACCTTTTGAGACAATATTTGTG
TTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGA
GGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTGTCCATTAACACTTATAAGTTAATTATGG
GTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTT
TAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTA
GTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGC
TATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACA
GGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAG
CCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGG
AAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTA
TTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCC
AAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTA
TGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCT
GTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTC
TCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAA
CCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAA
AATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCACCTATAAAAAATTACCTTGACAAAAATAG
TTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGATGAGCCAACATTGCACTGTGGATACATA
TCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAATATTTGCAAAACACGCAGACTTCTGTATC

>41149_41149_2_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000574590_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=821AA_BP=477
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY
SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP
LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK
KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG

--------------------------------------------------------------
>41149_41149_3_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000575318_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5254nt_BP=1465nt
GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG
GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC
CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT
GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA
ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG
AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA
TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG
GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC
AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG
GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG
GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA
TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA
GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA
ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG
GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGC
TGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACAT
TTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCAGTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGA
GAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACA
TATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCA
GAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCC
TTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAG
AACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTG
CTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCC
CCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACC
CGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGG
GCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCAT
TGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAA
GCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCA
TGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGA
CTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCAT
AAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTG
TGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCT
ATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGA
ATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACC
ACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCC
ATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAA
AGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTT
CACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGAC
TTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATT
ATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGG
TTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATT
TCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTG
TAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGG
AATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCAC
CATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATA
ACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCA
TGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAG
GCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTT
TAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGT
TTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAAC
CTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTG
GAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCAC
TTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTA
CAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGA
GGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAG
AAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACT
AATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGC
GCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAATATTTGCAAAACACGCAGACTTCTGTATCTGTATTTGGAAAA

>41149_41149_3_KANSL1-PHF20_KANSL1_chr17_44171925_ENST00000575318_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=821AA_BP=477
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY
SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP
LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK
KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KANSL1-PHF20

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KANSL1-PHF20

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KANSL1-PHF20

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source