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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KANSL1-PPP1R1B (FusionGDB2 ID:41150) |
Fusion Gene Summary for KANSL1-PPP1R1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KANSL1-PPP1R1B | Fusion gene ID: 41150 | Hgene | Tgene | Gene symbol | KANSL1 | PPP1R1B | Gene ID | 284058 | 84152 |
| Gene name | KAT8 regulatory NSL complex subunit 1 | protein phosphatase 1 regulatory inhibitor subunit 1B | |
| Synonyms | CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1 | DARPP-32|DARPP32 | |
| Cytomap | 17q21.31 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog | protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q7Z3B3 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000262419, ENST00000432791, ENST00000572904, ENST00000574590, ENST00000575318, ENST00000393476, ENST00000576248, | ENST00000254079, ENST00000394265, ENST00000394267, ENST00000579000, ENST00000580825, | |
| Fusion gene scores | * DoF score | 34 X 33 X 14=15708 | 17 X 10 X 9=1530 |
| # samples | 47 | 26 | |
| ** MAII score | log2(47/15708*10)=-5.0626949361014 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/1530*10)=-2.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KANSL1 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KANSL1(44239843)-PPP1R1B(37783559), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | KANSL1-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KANSL1-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KANSL1-PPP1R1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KANSL1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Hgene | KANSL1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Hgene | KANSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Tgene | PPP1R1B | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 10807923 |
| Fusion gene breakpoints across KANSL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PPP1R1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A8-A09G-01A | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| ChimerDB4 | BRCA | TCGA-A8-A09G-01A | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| ChimerDB4 | BRCA | TCGA-A8-A09G-01A | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| ChimerDB4 | BRCA | TCGA-A8-A09G-01A | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| ChimerDB4 | BRCA | TCGA-A8-A09G-01A | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
Top |
Fusion Gene ORF analysis for KANSL1-PPP1R1B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000262419 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000262419 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000432791 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000432791 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000572904 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000572904 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000572904 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000572904 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000572904 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000574590 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000574590 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000574590 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000574590 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000574590 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000575318 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000575318 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5CDS-5UTR | ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000262419 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000262419 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000432791 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000432791 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000572904 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000572904 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000574590 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000574590 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000575318 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000575318 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-3CDS | ENST00000393476 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000393476 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000393476 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000572904 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000572904 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000572904 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000576248 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000576248 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-3CDS | ENST00000576248 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000393476 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-5UTR | ENST00000393476 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000393476 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000393476 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-5UTR | ENST00000393476 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-5UTR | ENST00000572904 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000572904 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000576248 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-5UTR | ENST00000576248 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000576248 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| 5UTR-5UTR | ENST00000576248 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-5UTR | ENST00000576248 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-intron | ENST00000393476 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-intron | ENST00000393476 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-intron | ENST00000576248 | ENST00000394265 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| 5UTR-intron | ENST00000576248 | ENST00000394267 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37783559 | + |
| Frame-shift | ENST00000572904 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| Frame-shift | ENST00000572904 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| Frame-shift | ENST00000572904 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| Frame-shift | ENST00000574590 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| Frame-shift | ENST00000574590 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| Frame-shift | ENST00000574590 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| In-frame | ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000393476 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000393476 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000393476 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000574590 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000574590 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000574590 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000576248 | ENST00000254079 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000576248 | ENST00000579000 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-3CDS | ENST00000576248 | ENST00000580825 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000262419 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000262419 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000393476 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000393476 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000393476 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000432791 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000572904 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000574590 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000574590 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000574590 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000575318 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000254079 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000254079 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000394265 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000576248 | ENST00000394267 | KANSL1 | chr17 | 44270189 | - | PPP1R1B | chr17 | 37785423 | + |
| intron-5UTR | ENST00000576248 | ENST00000579000 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000579000 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000580825 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000576248 | ENST00000580825 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000262419 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000262419 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000262419 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000262419 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000393476 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000393476 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000393476 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000393476 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000432791 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000432791 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000432791 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000432791 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000572904 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000572904 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000572904 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000572904 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000574590 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000574590 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000574590 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000574590 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000575318 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000575318 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000575318 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000575318 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000576248 | ENST00000394265 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000576248 | ENST00000394265 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000576248 | ENST00000394267 | KANSL1 | chr17 | 44239843 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000576248 | ENST00000394267 | KANSL1 | chr17 | 44244846 | - | PPP1R1B | chr17 | 37783559 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000575318 | KANSL1 | chr17 | 44248221 | - | ENST00000580825 | PPP1R1B | chr17 | 37785423 | + | 1992 | 1323 | 34 | 1479 | 481 |
| ENST00000575318 | KANSL1 | chr17 | 44248221 | - | ENST00000254079 | PPP1R1B | chr17 | 37785423 | + | 2618 | 1323 | 34 | 1479 | 481 |
| ENST00000575318 | KANSL1 | chr17 | 44248221 | - | ENST00000579000 | PPP1R1B | chr17 | 37785423 | + | 2515 | 1323 | 34 | 1431 | 465 |
| ENST00000262419 | KANSL1 | chr17 | 44248221 | - | ENST00000580825 | PPP1R1B | chr17 | 37785423 | + | 2429 | 1760 | 471 | 1916 | 481 |
| ENST00000262419 | KANSL1 | chr17 | 44248221 | - | ENST00000254079 | PPP1R1B | chr17 | 37785423 | + | 3055 | 1760 | 471 | 1916 | 481 |
| ENST00000262419 | KANSL1 | chr17 | 44248221 | - | ENST00000579000 | PPP1R1B | chr17 | 37785423 | + | 2952 | 1760 | 471 | 1868 | 465 |
| ENST00000432791 | KANSL1 | chr17 | 44248221 | - | ENST00000580825 | PPP1R1B | chr17 | 37785423 | + | 2043 | 1374 | 85 | 1530 | 481 |
| ENST00000432791 | KANSL1 | chr17 | 44248221 | - | ENST00000254079 | PPP1R1B | chr17 | 37785423 | + | 2669 | 1374 | 85 | 1530 | 481 |
| ENST00000432791 | KANSL1 | chr17 | 44248221 | - | ENST00000579000 | PPP1R1B | chr17 | 37785423 | + | 2566 | 1374 | 85 | 1482 | 465 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000575318 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.03555133 | 0.9644487 |
| ENST00000575318 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.018831888 | 0.98116815 |
| ENST00000575318 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.014019847 | 0.9859802 |
| ENST00000262419 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.031288512 | 0.96871144 |
| ENST00000262419 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.019173445 | 0.9808265 |
| ENST00000262419 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.013372841 | 0.98662716 |
| ENST00000432791 | ENST00000580825 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.035958733 | 0.9640413 |
| ENST00000432791 | ENST00000254079 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.019805126 | 0.9801949 |
| ENST00000432791 | ENST00000579000 | KANSL1 | chr17 | 44248221 | - | PPP1R1B | chr17 | 37785423 | + | 0.014462851 | 0.9855371 |
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Fusion Genomic Features for KANSL1-PPP1R1B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| KANSL1 | chr17 | 44248220 | - | PPP1R1B | chr17 | 37785422 | + | 5.89E-06 | 0.99999416 |
| KANSL1 | chr17 | 44270188 | - | PPP1R1B | chr17 | 37785422 | + | 2.13E-06 | 0.99999785 |
| KANSL1 | chr17 | 44248220 | - | PPP1R1B | chr17 | 37783558 | + | 1.37E-06 | 0.9999987 |
| KANSL1 | chr17 | 44248220 | - | PPP1R1B | chr17 | 37785422 | + | 5.89E-06 | 0.99999416 |
| KANSL1 | chr17 | 44270188 | - | PPP1R1B | chr17 | 37785422 | + | 2.13E-06 | 0.99999785 |
| KANSL1 | chr17 | 44248220 | - | PPP1R1B | chr17 | 37783558 | + | 1.37E-06 | 0.9999987 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KANSL1-PPP1R1B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:44239843/chr17:37783559) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KANSL1 | . |
| FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000262419 | - | 2 | 15 | 283_314 | 429 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000432791 | - | 1 | 14 | 283_314 | 429 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000572904 | - | 2 | 15 | 283_314 | 429 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000574590 | - | 2 | 15 | 283_314 | 429 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPP1R1B | chr17:44248221 | chr17:37785423 | ENST00000254079 | 0 | 7 | 119_136 | 27 | 205.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | PPP1R1B | chr17:44248221 | chr17:37785423 | ENST00000394265 | 0 | 7 | 119_136 | 0 | 169.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | PPP1R1B | chr17:44248221 | chr17:37785423 | ENST00000394267 | 0 | 7 | 119_136 | 0 | 169.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | PPP1R1B | chr17:44248221 | chr17:37785423 | ENST00000580825 | 1 | 8 | 119_136 | 27 | 205.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000262419 | - | 2 | 15 | 850_882 | 429 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000432791 | - | 1 | 14 | 850_882 | 429 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000572904 | - | 2 | 15 | 850_882 | 429 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
| Hgene | KANSL1 | chr17:44248221 | chr17:37785423 | ENST00000574590 | - | 2 | 15 | 850_882 | 429 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
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Fusion Gene Sequence for KANSL1-PPP1R1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >41150_41150_1_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000254079_length(transcript)=3055nt_BP=1760nt TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGC TCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACC CCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGG CCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAG AGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAG GGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTG GGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTG TTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGG CTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTC CTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCT ACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTAC CCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGT TTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCT TTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTC >41150_41150_1_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000254079_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_2_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000579000_length(transcript)=2952nt_BP=1760nt TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGC TCTCAGAGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGG AGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAG AAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGG AGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAAC CTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGA AACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGT GTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCA CCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAG ATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATC CTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCA TAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGT TTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTG >41150_41150_2_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000579000_length(amino acids)=465AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_3_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000580825_length(transcript)=2429nt_BP=1760nt TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGC TCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACC CCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGG CCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAG AGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAG GGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTG GGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTG >41150_41150_3_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000262419_PPP1R1B_chr17_37785423_ENST00000580825_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_4_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000254079_length(transcript)=2669nt_BP=1374nt TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA TCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAG GAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTG AAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGG GAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCT GAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTG GATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCC TCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCA CCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCA CCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGA TGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACA CAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTC CTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGG GAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCA GGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCT >41150_41150_4_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000254079_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_5_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000579000_length(transcript)=2566nt_BP=1374nt TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA TCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGCTGTG CAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGG GAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTG AAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCC GAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCT GGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTT GTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCT GATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACA GCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACC CACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGG ATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCC CTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCG CCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTG >41150_41150_5_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000579000_length(amino acids)=465AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_6_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000580825_length(transcript)=2043nt_BP=1374nt TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA TCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAG GAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTG AAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGG GAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCT GAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTG GATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCC TCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCA >41150_41150_6_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000432791_PPP1R1B_chr17_37785423_ENST00000580825_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_7_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000254079_length(transcript)=2618nt_BP=1323nt GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCC ATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCG AAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTG AATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAG GATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGC CAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCA CTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGA GGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTC TAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCC CTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGC CCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAG AACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCC AGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACT GGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCA GGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAGGCCTGAACCCCTCCCGTGCTGTAATAAATCTTTGT >41150_41150_7_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000254079_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_8_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000579000_length(transcript)=2515nt_BP=1323nt GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCC ATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAAC CAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAA GAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTG GAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAG CCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATC GCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACT AAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTC ATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAA TTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAG GTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAG GCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGAC CTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCT >41150_41150_8_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000579000_length(amino acids)=465AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- >41150_41150_9_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000580825_length(transcript)=1992nt_BP=1323nt GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTATCCGGCGCAGGAGACCAACGCCTGCC ATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCG AAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTG AATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAG GATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGC CAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCA CTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGA GGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTC >41150_41150_9_KANSL1-PPP1R1B_KANSL1_chr17_44248221_ENST00000575318_PPP1R1B_chr17_37785423_ENST00000580825_length(amino acids)=481AA_BP=430 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLSGAGDQRLPCCSGSQSTPHQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KANSL1-PPP1R1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KANSL1-PPP1R1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KANSL1-PPP1R1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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