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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KANSL2-LAMC3 (FusionGDB2 ID:41159)

Fusion Gene Summary for KANSL2-LAMC3

check button Fusion gene summary
Fusion gene informationFusion gene name: KANSL2-LAMC3
Fusion gene ID: 41159
HgeneTgene
Gene symbol

KANSL2

LAMC3

Gene ID

54934

10319

Gene nameKAT8 regulatory NSL complex subunit 2laminin subunit gamma 3
SynonymsC12orf41|NSL2OCCM
Cytomap

12q13.11

9q34.12

Type of geneprotein-codingprotein-coding
DescriptionKAT8 regulatory NSL complex subunit 2NSL complex protein NSL2non-specific lethal 2 homologlaminin subunit gamma-3laminin, gamma 3laminin-12 subunit gammalaminin-14 subunit gammalaminin-15 subunit gamma
Modification date2020031320200313
UniProtAcc

Q9H9L4

Q9Y6N6

Ensembl transtripts involved in fusion geneENST00000357861, ENST00000420613, 
ENST00000550347, ENST00000553086, 
ENST00000548701, 		ENST00000480883, 
ENST00000361069, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 6 X 5=180
# samples 46
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KANSL2 [Title/Abstract] AND LAMC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKANSL2(49062889)-LAMC3(133954536), # samples:1
Anticipated loss of major functional domain due to fusion event.KANSL2-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KANSL2-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KANSL2-LAMC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKANSL2

GO:0043981

histone H4-K5 acetylation

20018852

HgeneKANSL2

GO:0043982

histone H4-K8 acetylation

20018852

HgeneKANSL2

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across KANSL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAMC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-4065-02AKANSL2chr12

49062889

-LAMC3chr9

133954536

+


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Fusion Gene ORF analysis for KANSL2-LAMC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357861ENST00000480883KANSL2chr12

49062889

-LAMC3chr9

133954536

+
5CDS-intronENST00000420613ENST00000480883KANSL2chr12

49062889

-LAMC3chr9

133954536

+
5CDS-intronENST00000550347ENST00000480883KANSL2chr12

49062889

-LAMC3chr9

133954536

+
5CDS-intronENST00000553086ENST00000480883KANSL2chr12

49062889

-LAMC3chr9

133954536

+
Frame-shiftENST00000357861ENST00000361069KANSL2chr12

49062889

-LAMC3chr9

133954536

+
Frame-shiftENST00000420613ENST00000361069KANSL2chr12

49062889

-LAMC3chr9

133954536

+
In-frameENST00000550347ENST00000361069KANSL2chr12

49062889

-LAMC3chr9

133954536

+
In-frameENST00000553086ENST00000361069KANSL2chr12

49062889

-LAMC3chr9

133954536

+
intron-3CDSENST00000548701ENST00000361069KANSL2chr12

49062889

-LAMC3chr9

133954536

+
intron-intronENST00000548701ENST00000480883KANSL2chr12

49062889

-LAMC3chr9

133954536

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000550347KANSL2chr1249062889-ENST00000361069LAMC3chr9133954536+36921469442419791
ENST00000553086KANSL2chr1249062889-ENST00000361069LAMC3chr9133954536+34091186312136701

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000550347ENST00000361069KANSL2chr1249062889-LAMC3chr9133954536+0.0258674940.97413254
ENST00000553086ENST00000361069KANSL2chr1249062889-LAMC3chr9133954536+0.0213874760.97861254

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Fusion Genomic Features for KANSL2-LAMC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KANSL2chr1249062888-LAMC3chr9133954535+1.16E-050.99998844
KANSL2chr1249062888-LAMC3chr9133954535+1.16E-050.99998844

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KANSL2-LAMC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:49062889/chr9:133954536)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KANSL2

Q9H9L4

LAMC3

Q9Y6N6

FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852}.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281410_149212591576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281523_156712591576.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281073_113412591576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281201_122812591576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128271_32612591576.0DomainLaminin EGF-like 1
TgeneLAMC3chr12:49062889chr9:133954536ENST00000361069212831_27012591576.0DomainLaminin N-terminal
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128327_38212591576.0DomainLaminin EGF-like 2
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128383_42912591576.0DomainLaminin EGF-like 3
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128430_47912591576.0DomainLaminin EGF-like 4
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128480_48912591576.0DomainLaminin EGF-like 5%3B first part
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128499_67212591576.0DomainLaminin IV type A
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128673_70612591576.0DomainLaminin EGF-like 5%3B second part
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128707_75412591576.0DomainLaminin EGF-like 6
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128755_80912591576.0DomainLaminin EGF-like 7
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128810_86512591576.0DomainLaminin EGF-like 8
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128866_91612591576.0DomainLaminin EGF-like 9
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128917_96412591576.0DomainLaminin EGF-like 10
TgeneLAMC3chr12:49062889chr9:133954536ENST000003610692128965_101312591576.0DomainLaminin EGF-like 11
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281059_106112591576.0MotifCell attachment site
TgeneLAMC3chr12:49062889chr9:133954536ENST0000036106921281014_157512591576.0RegionNote=Domain II and I


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Fusion Gene Sequence for KANSL2-LAMC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41159_41159_1_KANSL2-LAMC3_KANSL2_chr12_49062889_ENST00000550347_LAMC3_chr9_133954536_ENST00000361069_length(transcript)=3692nt_BP=1469nt
GAGCGGCGCGGCAGAGTGCGGCGCAGCGCAGCTCCTGAGGTAAGATGGCGGTGCTCTTTCCTCTAAGCTCTTGCGGTTGGGCTGCTATTT
CGCTCTTTTTGTCAGCTCAGAGCTGCTACTCCGCCTCAAAGCAGTGTCAGAGTCAGTCTCCTTCCTGCAGGCTTCCAGGAGCCAGGATCT
CCGGTGACTGGAGCCGTAGGACAAAATGGCGCTCGCATAGGCTTCCGAGGCCAGGCCCAGTCGTGCGCTCTGAGGCAGGCCGGGACAAAG
GCGGCGTGCGGGGAGGCGGCGTGGCCGCCGCGTGGGGCTGGTGTTGTCGCTTCCCTTCGTGCTGCAGCTGTGCGAGTCCTGAAGATACAT
TCAGCGTGGTGTGGTTCGGGGTGGGGCCGGGCATGGAGGGACACGCTAAAGGGAGGCAAAGCCACAGATGCCTGTGGAGACTTGGGGAGG
GCGGCGGGGACTTACGGAGCGTACCTTACGGGGACGACTTCTGCATGTCCTTTGGAAACTGTCCGCGCGATCTGTGTGGAGCAGGAATTT
TCGGGAAGGGTAAGGGCTTTTTGGTCTTTCGTTTGACCCCGCAGGTTTTGGTTATGAACAGGATTCGGATTCACGTCTTGCCAACCAATC
GGGGGAGGATCACTCCAGTGCCCAGGTCTCAGGAACCTCTGTCTTGTGCATTCACTCATCGTCCATGCTCTCACCCTCGTCTGGAGGGGC
AGGAGTTTTGCATTAAGCATATCCTTGAAGACAAGAATGCACCCTTCAAGCAGTGTAGTTATATATCGACGAAGAATGGAAAAAGATGTC
CCAATGCTGCCCCAAAGCCAGAGAAGAAAGATGGGGTGTCCTTCTGTGCTGAACATGTCCGTAGGAATGCCCTGGCACTTCATGCTCAAA
TGAAGAAGACCAACCCAGGGCCTGTGGGTGAAACACTCCTGTGCCAGCTGAGCTCATATGCTAAGACAGAGCTGGGGTCTCAGACTCCAG
AAAGTAGTCGCAGTGAAGCCAGCCGAATACTAGATGAAGACAGCTGGAGTGATGGGGAGCAGGAACCCATTACTGTGGATCAGACATGGA
GAGGTGACCCTGACAGTGAAGCTGATAGCATAGACAGTGATCAAGAAGATCCCCTAAAACATGCTGGTGTCTACACAGCAGAAGAAGTGG
CCCTGATTATGCGTGAAAAGCTAATTCGTTTGCAGTCGTTGTATATTGATCAGTTTAAACGACTTCAGCATCTGCTCAAGGAGAAGAAGC
GCCGATACTTACATAATCGCAAAGTGGAACATGAAGCTCTAGGCAGTAGTCTCCTGACTGGCCCAGAGGGACTTTTGGCCAAAGAACGAG
AGAACTTAAAGCGATTAAAATGTCTGCGACGATACCGCCAGCGCTATGGAGTGGAAGCCTTACTGCATAGGCAGTTGAAGGAACGGAGAA
TGCTGGCCACAGATGGTGCTGCCCAACAGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAAGGCGAAGGCCCTGGAGAAGACAGTTG
CATCATGGCAGCACATGGCCACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCTACGGCAAACAGAACCCCTCACAAAGC
TGCACCAGGAGGCCAGAGCCGCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGACTGTCATGGGAGCCAGGACTCTGCTGG
CTGATCTGGAAGGAATGAAGCTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAAGGCAGACTCCGTCAGTGACAGACTCC
TTGCAGACACGAGAAAGAAGACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTCCTCCAGTGCCAAGAAGAAGGGCAGAG
AAGCAGAGGTGTTGGCCAAGGACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACAGGCGCACCGCCGTGCCAGCAGGCTCA
CCAGCCAGACGCAAGCCACGCTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAGACAGGAGCTGGAGGAAGCTGAGCGGG
TGGGTGCTGGGCTGAGCGAGATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGACATCGAGACCTTGTCAGAGCTGCTTG
CCAGGCTGGGGTCGCTGGACACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGCACTAGAACGCCTGAGGCTGCAGCTGG
GCTCCCCGGGGTCCTTGCAGAGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCTGCAGATCCAGGGCTTCGAGAGTGACC
TCGCCGAGATCCGCGCCGACAAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTGTGCCAGCTGGCAGTGAGGGCTGCCCA
GATCCCCGGCACACACTCCCCCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACAGGTGTGCCCATACAGACATTCCCCGG
AGCCGGCTGCTGTGAACTCGCCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTTCTTCCCTGCCAGCAGGACTGAGTGTG
CGTACCCAGTTCACCTGGACATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACACCCCAGTGTCAATAACATACACACGTG
AGGGTGCATGTCTGTGTGTATGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTACGGTCCACACACATTACAGTCCACAG
CTGTTGTGAGAGCCACCTGTGTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGATGCCCTGGGGTGCTACATCCACTCACT
CCAGATAGCAGGGAGGTCTCAGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCCCTAGTCCCAGAGCTGGCTGCCCTCTG
TTTCACAGCAGCTCCCTGACCTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGGACCAACAGGCCAAGAAATGCAAGATC
CCGGGAGGGTTCTTAGCAGCAGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCTAGTCTGGCTAGAGCAAGGCCCATTCC
TGGCGGGGGTGTCATTGCCTTCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATGCCCTGAGGGAATGGCCCACCCTGGCC
TGTACCCACTTCAGCCTGTGATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGCTCAGGCTACCAGGAGCACGCCTCTGT
GCCCCCGGCAACCCAGTTGACCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGCCATGCGGGAGGCCACCAGGGTGTGCA
AGCCTGGCTGCCATTCCAGTCTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGGCCTCTGCCCAGGACTCCTCAGCATTT
CCTCTTGGCATCCCTCCCCTCTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGGAAGTCAGGCACCTCTGCGGGCCCAGC
CCCCTCCCGTGGCTCCCCTGACAGGGGCAGGGGTAGGGCAGCAGCACAGACCAATTCCGTTGAACGTGGAAATAAAGGACCCTTTCACTG

>41159_41159_1_KANSL2-LAMC3_KANSL2_chr12_49062889_ENST00000550347_LAMC3_chr9_133954536_ENST00000361069_length(amino acids)=791AA_BP=474
MAVLFPLSSCGWAAISLFLSAQSCYSASKQCQSQSPSCRLPGARISGDWSRRTKWRSHRLPRPGPVVRSEAGRDKGGVRGGGVAAAWGWC
CRFPSCCSCASPEDTFSVVWFGVGPGMEGHAKGRQSHRCLWRLGEGGGDLRSVPYGDDFCMSFGNCPRDLCGAGIFGKGKGFLVFRLTPQ
VLVMNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSF
CAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQ
EDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQR
YGVEALLHRQLKERRMLATDGAAQQPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSS
VQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKA
LLRERKQAHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQA

--------------------------------------------------------------
>41159_41159_2_KANSL2-LAMC3_KANSL2_chr12_49062889_ENST00000553086_LAMC3_chr9_133954536_ENST00000361069_length(transcript)=3409nt_BP=1186nt
CTCTTGCGGTTGGGCTGCTATTTCGCTCTTTTTGTCAGCTCAGAGCTGCTACTCCGCCTCAAAGCAGTGTCAGAGTCAGTCTCCTTCCTG
CAGGCTTCCAGGAGCCAGGATCTCCGGTGACTGGAGCCGTAGGACAAAATGGCGCTCGCATAGGCTTCCGAGGCCAGGCCCAGTCGTGCG
CTCTGAGGCAGGCCGGGACAAAGGCGGCGTGCGGGGAGGCGGCGTGGCCGCCGCGTGGGGCTGGTGTTGTCGCTTCCCTTCGTGCTGCAG
CTGTGCGAGTCCTGAAGATACATTCAGCGTGGTTTTGGTTATGAACAGGATTCGGATTCACGTCTTGCCAACCAATCGGGGGAGGATCAC
TCCAGTGCCCAGGTCTCAGGAACCTCTGTCTTGTGCATTCACTCATCGTCCATGCTCTCACCCTCGTCTGGAGGGGCAGGAGTTTTGCAT
TAAGCATATCCTTGAAGACAAGAATGCACCCTTCAAGCAGTGTAGTTATATATCGACGAAGAATGGAAAAAGATGTCCCAATGCTGCCCC
AAAGCCAGAGAAGAAAGATGGGGTGTCCTTCTGTGCTGAACATGTCCGTAGGAATGCCCTGGCACTTCATGCTCAAATGAAGAAGACCAA
CCCAGGGCCTGTGGGTGAAACACTCCTGTGCCAGCTGAGCTCATATGCTAAGACAGAGCTGGGGTCTCAGACTCCAGAAAGTAGTCGCAG
TGAAGCCAGCCGAATACTAGATGAAGACAGCTGGAGTGATGGGGAGCAGGAACCCATTACTGTGGATCAGACATGGAGAGGTGACCCTGA
CAGTGAAGCTGATAGCATAGACAGTGATCAAGAAGATCCCCTAAAACATGCTGGTGTCTACACAGCAGAAGAAGTGGCCCTGATTATGCG
TGAAAAGCTAATTCGTTTGCAGTCGTTGTATATTGATCAGTTTAAACGACTTCAGCATCTGCTCAAGGAGAAGAAGCGCCGATACTTACA
TAATCGCAAAGTGGAACATGAAGCTCTAGGCAGTAGTCTCCTGACTGGCCCAGAGGGACTTTTGGCCAAAGAACGAGAGAACTTAAAGCG
ATTAAAATGTCTGCGACGATACCGCCAGCGCTATGGAGTGGAAGCCTTACTGCATAGGCAGTTGAAGGAACGGAGAATGCTGGCCACAGA
TGGTGCTGCCCAACAGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAAGGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGCA
CATGGCCACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCTACGGCAAACAGAACCCCTCACAAAGCTGCACCAGGAGGC
CAGAGCCGCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGACTGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGG
AATGAAGCTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAAGGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAG
AAAGAAGACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTCCTCCAGTGCCAAGAAGAAGGGCAGAGAAGCAGAGGTGTT
GGCCAAGGACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACAGGCGCACCGCCGTGCCAGCAGGCTCACCAGCCAGACGCA
AGCCACGCTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAGACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCT
GAGCGAGATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGACATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGTC
GCTGGACACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGCACTAGAACGCCTGAGGCTGCAGCTGGGCTCCCCGGGGTC
CTTGCAGAGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCTGCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCG
CGCCGACAAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTGTGCCAGCTGGCAGTGAGGGCTGCCCAGATCCCCGGCACA
CACTCCCCCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACAGGTGTGCCCATACAGACATTCCCCGGAGCCGGCTGCTGT
GAACTCGCCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTTCTTCCCTGCCAGCAGGACTGAGTGTGCGTACCCAGTTCA
CCTGGACATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACACCCCAGTGTCAATAACATACACACGTGAGGGTGCATGTCT
GTGTGTATGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTACGGTCCACACACATTACAGTCCACAGCTGTTGTGAGAGC
CACCTGTGTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGATGCCCTGGGGTGCTACATCCACTCACTCCAGATAGCAGGG
AGGTCTCAGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCCCTAGTCCCAGAGCTGGCTGCCCTCTGTTTCACAGCAGCT
CCCTGACCTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGGACCAACAGGCCAAGAAATGCAAGATCCCGGGAGGGTTCT
TAGCAGCAGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCTAGTCTGGCTAGAGCAAGGCCCATTCCTGGCGGGGGTGTC
ATTGCCTTCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATGCCCTGAGGGAATGGCCCACCCTGGCCTGTACCCACTTCA
GCCTGTGATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGCTCAGGCTACCAGGAGCACGCCTCTGTGCCCCCGGCAACC
CAGTTGACCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGCCATGCGGGAGGCCACCAGGGTGTGCAAGCCTGGCTGCCA
TTCCAGTCTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGGCCTCTGCCCAGGACTCCTCAGCATTTCCTCTTGGCATCC
CTCCCCTCTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGGAAGTCAGGCACCTCTGCGGGCCCAGCCCCCTCCCGTGGC

>41159_41159_2_KANSL2-LAMC3_KANSL2_chr12_49062889_ENST00000553086_LAMC3_chr9_133954536_ENST00000361069_length(amino acids)=701AA_BP=384
MSAQSCYSASKQCQSQSPSCRLPGARISGDWSRRTKWRSHRLPRPGPVVRSEAGRDKGGVRGGGVAAAWGWCCRFPSCCSCASPEDTFSV
VLVMNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSF
CAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQ
EDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQR
YGVEALLHRQLKERRMLATDGAAQQPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSS
VQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKA
LLRERKQAHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQA

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Fusion Gene PPI Analysis for KANSL2-LAMC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KANSL2-LAMC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KANSL2-LAMC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource