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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KAT5-KAT5 (FusionGDB2 ID:41190)

Fusion Gene Summary for KAT5-KAT5

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT5-KAT5
Fusion gene ID: 41190
HgeneTgene
Gene symbol

KAT5

KAT5

Gene ID

10524

10524

Gene namelysine acetyltransferase 5lysine acetyltransferase 5
SynonymsESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2ESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT560 kDa Tat-interactive proteinHIV-1 Tat interactive protein, 60kDaK(lysine) acetyltransferase 5K-acetyltransferase 5Tat interacting protein, 60kDacPLA(2)-interacting proteincPLA2 interacting proteinhistone acetyltranshistone acetyltransferase KAT560 kDa Tat-interactive proteinHIV-1 Tat interactive protein, 60kDaK(lysine) acetyltransferase 5K-acetyltransferase 5Tat interacting protein, 60kDacPLA(2)-interacting proteincPLA2 interacting proteinhistone acetyltrans
Modification date2020031520200315
UniProtAcc

Q92993

Q92993

Ensembl transtripts involved in fusion geneENST00000341318, ENST00000352980, 
ENST00000377046, ENST00000530446, 
ENST00000534650, ENST00000525204, 
ENST00000525204, ENST00000534650, 
ENST00000341318, ENST00000352980, 
ENST00000377046, ENST00000530446, 
Fusion gene scores* DoF score1 X 2 X 1=21 X 2 X 1=2
# samples 22
** MAII scorelog2(2/2*10)=3.32192809488736log2(2/2*10)=3.32192809488736
Context

PubMed: KAT5 [Title/Abstract] AND KAT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAT5(65482186)-KAT5(65480241), # samples:2
Anticipated loss of major functional domain due to fusion event.KAT5-KAT5 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT5-KAT5 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT5

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14966270

HgeneKAT5

GO:0010212

response to ionizing radiation

18397884

HgeneKAT5

GO:0010508

positive regulation of autophagy

30704899

HgeneKAT5

GO:0016573

histone acetylation

10966108

HgeneKAT5

GO:0018394

peptidyl-lysine acetylation

30704899

HgeneKAT5

GO:0032703

negative regulation of interleukin-2 production

17360565

HgeneKAT5

GO:0045892

negative regulation of transcription, DNA-templated

17360565

HgeneKAT5

GO:0045893

positive regulation of transcription, DNA-templated

14966270

HgeneKAT5

GO:0071392

cellular response to estradiol stimulus

23637611

HgeneKAT5

GO:1901985

positive regulation of protein acetylation

24012345

TgeneKAT5

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14966270

TgeneKAT5

GO:0010212

response to ionizing radiation

18397884

TgeneKAT5

GO:0010508

positive regulation of autophagy

30704899

TgeneKAT5

GO:0016573

histone acetylation

10966108

TgeneKAT5

GO:0018394

peptidyl-lysine acetylation

30704899

TgeneKAT5

GO:0032703

negative regulation of interleukin-2 production

17360565

TgeneKAT5

GO:0045892

negative regulation of transcription, DNA-templated

17360565

TgeneKAT5

GO:0045893

positive regulation of transcription, DNA-templated

14966270

TgeneKAT5

GO:0071392

cellular response to estradiol stimulus

23637611

TgeneKAT5

GO:1901985

positive regulation of protein acetylation

24012345


check buttonFusion gene breakpoints across KAT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KAT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA344110KAT5chr11

65484234

+KAT5chr11

65481975

+
ChiTaRS5.0N/ABE731511KAT5chr11

65482186

+KAT5chr11

65480241

+
ChiTaRS5.0N/ACR735169KAT5chr11

65482186

+KAT5chr11

65480241

+


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Fusion Gene ORF analysis for KAT5-KAT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000341318ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000352980ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000377046ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000530446ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-3UTRENST00000534650ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000341318ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000341318ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000352980ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000352980ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000377046ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000377046ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000530446ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000530446ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-5UTRENST00000534650ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-5UTRENST00000534650ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
5CDS-intronENST00000341318ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000352980ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000377046ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000530446ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
5CDS-intronENST00000534650ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+
Frame-shiftENST00000341318ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000341318ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000341318ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000341318ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000352980ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000352980ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000352980ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000352980ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000377046ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000377046ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000377046ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000377046ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000530446ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000530446ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000530446ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000530446ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000534650ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000534650ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000534650ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
Frame-shiftENST00000534650ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
In-frameENST00000341318ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000341318ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000352980ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000377046ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000530446ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
In-frameENST00000534650ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000341318KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000341318KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000352980KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000352980KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000377046KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000377046KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3CDSENST00000525204ENST00000530446KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-3CDSENST00000525204ENST00000530446KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-3UTRENST00000525204ENST00000525204KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-5UTRENST00000525204ENST00000534650KAT5chr11

65484234

+KAT5chr11

65481975

+
intron-5UTRENST00000525204ENST00000534650KAT5chr11

65482186

+KAT5chr11

65480241

+
intron-intronENST00000525204ENST00000525204KAT5chr11

65484234

+KAT5chr11

65481975

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KAT5-KAT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KAT5-KAT5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65482186/chr11:65480241)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT5

Q92993

KAT5

Q92993

FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). {ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:15196461}.FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). {ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:15196461}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKAT5chr11:65484234chr11:65481975ENST00000341318013227_5040547.0DomainMYST-type HAT
TgeneKAT5chr11:65484234chr11:65481975ENST00000352980013227_5040462.0DomainMYST-type HAT
TgeneKAT5chr11:65484234chr11:65481975ENST00000377046014227_5040514.0DomainMYST-type HAT
TgeneKAT5chr11:65484234chr11:65481975ENST00000530446012227_5040495.0DomainMYST-type HAT
TgeneKAT5chr11:65484234chr11:65481975ENST00000341318013377_3830547.0RegionAcetyl-CoA binding
TgeneKAT5chr11:65484234chr11:65481975ENST00000352980013377_3830462.0RegionAcetyl-CoA binding
TgeneKAT5chr11:65484234chr11:65481975ENST00000377046014377_3830514.0RegionAcetyl-CoA binding
TgeneKAT5chr11:65484234chr11:65481975ENST00000530446012377_3830495.0RegionAcetyl-CoA binding
TgeneKAT5chr11:65484234chr11:65481975ENST00000341318013260_2850547.0Zinc fingerC2HC MYST-type
TgeneKAT5chr11:65484234chr11:65481975ENST00000352980013260_2850462.0Zinc fingerC2HC MYST-type
TgeneKAT5chr11:65484234chr11:65481975ENST00000377046014260_2850514.0Zinc fingerC2HC MYST-type
TgeneKAT5chr11:65484234chr11:65481975ENST00000530446012260_2850495.0Zinc fingerC2HC MYST-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT5chr11:65484234chr11:65481975ENST00000341318+113227_5040547.0DomainMYST-type HAT
HgeneKAT5chr11:65484234chr11:65481975ENST00000352980+113227_5040462.0DomainMYST-type HAT
HgeneKAT5chr11:65484234chr11:65481975ENST00000377046+114227_5040514.0DomainMYST-type HAT
HgeneKAT5chr11:65484234chr11:65481975ENST00000530446+112227_5040495.0DomainMYST-type HAT
HgeneKAT5chr11:65484234chr11:65481975ENST00000341318+113377_3830547.0RegionAcetyl-CoA binding
HgeneKAT5chr11:65484234chr11:65481975ENST00000352980+113377_3830462.0RegionAcetyl-CoA binding
HgeneKAT5chr11:65484234chr11:65481975ENST00000377046+114377_3830514.0RegionAcetyl-CoA binding
HgeneKAT5chr11:65484234chr11:65481975ENST00000530446+112377_3830495.0RegionAcetyl-CoA binding
HgeneKAT5chr11:65484234chr11:65481975ENST00000341318+113260_2850547.0Zinc fingerC2HC MYST-type
HgeneKAT5chr11:65484234chr11:65481975ENST00000352980+113260_2850462.0Zinc fingerC2HC MYST-type
HgeneKAT5chr11:65484234chr11:65481975ENST00000377046+114260_2850514.0Zinc fingerC2HC MYST-type
HgeneKAT5chr11:65484234chr11:65481975ENST00000530446+112260_2850495.0Zinc fingerC2HC MYST-type


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Fusion Gene Sequence for KAT5-KAT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KAT5-KAT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKAT5chr11:65484234chr11:65481975ENST00000341318013368_5130547.0ATF2
TgeneKAT5chr11:65484234chr11:65481975ENST00000352980013368_5130462.0ATF2
TgeneKAT5chr11:65484234chr11:65481975ENST00000377046014368_5130514.0ATF2
TgeneKAT5chr11:65484234chr11:65481975ENST00000530446012368_5130495.0ATF2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT5chr11:65484234chr11:65481975ENST00000341318+113368_5130547.0ATF2
HgeneKAT5chr11:65484234chr11:65481975ENST00000352980+113368_5130462.0ATF2
HgeneKAT5chr11:65484234chr11:65481975ENST00000377046+114368_5130514.0ATF2
HgeneKAT5chr11:65484234chr11:65481975ENST00000530446+112368_5130495.0ATF2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KAT5-KAT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KAT5-KAT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource