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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KAT6A-ASXL2 (FusionGDB2 ID:41198)

Fusion Gene Summary for KAT6A-ASXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6A-ASXL2
Fusion gene ID: 41198
HgeneTgene
Gene symbol

KAT6A

ASXL2

Gene ID

7994

55252

Gene namelysine acetyltransferase 6AASXL transcriptional regulator 2
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220ASXH2|SHAPNS
Cytomap

8p11.21

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2
Modification date2020031320200313
UniProtAcc

Q92794

Q76L83

Ensembl transtripts involved in fusion geneENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000272341, ENST00000336112, 
ENST00000404843, ENST00000497092, 
ENST00000435504, 
Fusion gene scores* DoF score26 X 32 X 13=1081611 X 14 X 8=1232
# samples 4216
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT6A [Title/Abstract] AND ASXL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAT6A(41909478)-ASXL2(25962260), # samples:1
KAT6A(41800309)-ASXL2(26068436), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358

TgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

TgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

TgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4myelodysplastic syndromeAB084281KAT6Achr8

41909478

ASXL2chr2

25962260
ChimerKB3..KAT6Achr8

41800310

ASXL2chr2

26068432

-
ChiTaRS5.0N/AAB084281KAT6Achr8

41800309

-ASXL2chr2

26068436

-


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Fusion Gene ORF analysis for KAT6A-ASXL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265713ENST00000272341KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000265713ENST00000272341KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-5UTRENST00000265713ENST00000336112KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000265713ENST00000336112KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-5UTRENST00000396930ENST00000272341KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000396930ENST00000272341KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-5UTRENST00000396930ENST00000336112KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000396930ENST00000336112KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-5UTRENST00000406337ENST00000272341KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000406337ENST00000272341KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-5UTRENST00000406337ENST00000336112KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-5UTRENST00000406337ENST00000336112KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000265713ENST00000404843KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000265713ENST00000404843KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000265713ENST00000497092KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000265713ENST00000497092KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000396930ENST00000404843KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000396930ENST00000404843KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000396930ENST00000497092KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000396930ENST00000497092KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000406337ENST00000404843KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000406337ENST00000404843KAT6Achr8

41800309

-ASXL2chr2

26068436

-
5CDS-intronENST00000406337ENST00000497092KAT6Achr8

41800310

ASXL2chr2

26068432

-
5CDS-intronENST00000406337ENST00000497092KAT6Achr8

41800309

-ASXL2chr2

26068436

-
Frame-shiftENST00000406337ENST00000435504KAT6Achr8

41800310

ASXL2chr2

26068432

-
Frame-shiftENST00000406337ENST00000435504KAT6Achr8

41800309

-ASXL2chr2

26068436

-
In-frameENST00000265713ENST00000435504KAT6Achr8

41800310

ASXL2chr2

26068432

-
In-frameENST00000265713ENST00000435504KAT6Achr8

41800309

-ASXL2chr2

26068436

-
In-frameENST00000396930ENST00000435504KAT6Achr8

41800310

ASXL2chr2

26068432

-
In-frameENST00000396930ENST00000435504KAT6Achr8

41800309

-ASXL2chr2

26068436

-
intron-3CDSENST00000485568ENST00000435504KAT6Achr8

41800310

ASXL2chr2

26068432

-
intron-3CDSENST00000485568ENST00000435504KAT6Achr8

41800309

-ASXL2chr2

26068436

-
intron-3UTRENST00000265713ENST00000336112KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000265713ENST00000435504KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000396930ENST00000336112KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000396930ENST00000435504KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000406337ENST00000336112KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000406337ENST00000435504KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000485568ENST00000336112KAT6Achr8

41909478

ASXL2chr2

25962260

intron-3UTRENST00000485568ENST00000435504KAT6Achr8

41909478

ASXL2chr2

25962260

intron-5UTRENST00000485568ENST00000272341KAT6Achr8

41800310

ASXL2chr2

26068432

-
intron-5UTRENST00000485568ENST00000272341KAT6Achr8

41800309

-ASXL2chr2

26068436

-
intron-5UTRENST00000485568ENST00000336112KAT6Achr8

41800310

ASXL2chr2

26068432

-
intron-5UTRENST00000485568ENST00000336112KAT6Achr8

41800309

-ASXL2chr2

26068436

-
intron-intronENST00000265713ENST00000272341KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000265713ENST00000404843KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000265713ENST00000497092KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000396930ENST00000272341KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000396930ENST00000404843KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000396930ENST00000497092KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000406337ENST00000272341KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000406337ENST00000404843KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000406337ENST00000497092KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000485568ENST00000272341KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000485568ENST00000404843KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000485568ENST00000404843KAT6Achr8

41800310

ASXL2chr2

26068432

-
intron-intronENST00000485568ENST00000404843KAT6Achr8

41800309

-ASXL2chr2

26068436

-
intron-intronENST00000485568ENST00000497092KAT6Achr8

41909478

ASXL2chr2

25962260

intron-intronENST00000485568ENST00000497092KAT6Achr8

41800310

ASXL2chr2

26068432

-
intron-intronENST00000485568ENST00000497092KAT6Achr8

41800309

-ASXL2chr2

26068436

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265713KAT6Achr841800310ENST00000435504ASXL2chr226068432-15375284841270982228
ENST00000396930KAT6Achr841800310ENST00000435504ASXL2chr226068432-15507298054472302228
ENST00000265713KAT6Achr841800309-ENST00000435504ASXL2chr226068436-15375284841270982228
ENST00000396930KAT6Achr841800309-ENST00000435504ASXL2chr226068436-15507298054472302228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000435504KAT6Achr841800309-ASXL2chr226068436-0.0002058580.9997942
ENST00000396930ENST00000435504KAT6Achr841800309-ASXL2chr226068436-0.0002414460.99975854

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Fusion Genomic Features for KAT6A-ASXL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KAT6A-ASXL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41909478/chr2:25962260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

ASXL2

Q76L83

FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417371_3798122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417788_8018122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518371_3798122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518788_8018122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518371_3798122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518788_8018122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417504_7788122005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-141795_1718122005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518504_7788122005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-151895_1718122005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518504_7788122005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-151895_1718122005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171_1448122005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417488_7788122005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-141752_1668122005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417645_6498122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417654_6608122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181_1448122005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518488_7788122005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-151852_1668122005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518645_6498122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518654_6608122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181_1448122005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518488_7788122005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-151852_1668122005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518645_6498122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518654_6608122005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417206_2658122005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417259_3138122005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417537_5628122005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518206_2658122005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518259_3138122005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518537_5628122005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518206_2658122005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518259_3138122005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518537_5628122005.0Zinc fingerC2HC MYST-type
TgeneASXL2chr8:41800309chr2:26068436ENST000002723410131173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000027234101395_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST000004048430101173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000040484301095_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST000004355040131173_1176191436.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013303_307191436.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013654_684191436.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013687_739191436.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000043550401395_235191436.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000027234101311_860919.0DomainHTH HARE-type
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013274_3830919.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST0000040484301011_860919.0DomainHTH HARE-type
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010274_3830919.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013274_383191436.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013174_1780919.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010174_1780919.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013174_178191436.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013887_891191436.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST000002723410131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr8:41800309chr2:26068436ENST000004048430101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr8:41800309chr2:26068436ENST000004355040131397_1434191436.0Zinc fingerNote=PHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171019_10268122005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171069_10788122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171147_11508122005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171221_12428122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171267_13028122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171411_14148122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171593_15978122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171643_17048122005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171897_19778122005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417989_9958122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181019_10268122005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181069_10788122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181147_11508122005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181221_12428122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181267_13028122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181411_14148122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181593_15978122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181643_17048122005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181897_19778122005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518989_9958122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181019_10268122005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181069_10788122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181147_11508122005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181221_12428122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181267_13028122005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181411_14148122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181593_15978122005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181643_17048122005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181897_19778122005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518989_9958122005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171913_19488122005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181913_19488122005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181913_19488122005.0RegionNote=Required for activation of RUNX1-2
TgeneASXL2chr8:41800309chr2:26068436ENST0000043550401311_86191436.0DomainHTH HARE-type


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Fusion Gene Sequence for KAT6A-ASXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41198_41198_1_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000265713_ASXL2_chr2_26068436_ENST00000435504_length(transcript)=15375nt_BP=2848nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGCA
TAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTG
AGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAA
GGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTAC
TCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGAT
TTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGA
TCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGA
TCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGAT
AAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGC
ATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGA
TGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCT
TCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAA
GCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAA
GGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTC
ATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAG
GAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAA
GAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCA
ATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAA
CAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTA
CTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAA
ACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACT
GCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTA
CTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCTTTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCT
GCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGAGATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGG
GAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTTGTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATT
TCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGTTGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAA
TGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGGCAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGA
AGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCTTTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCT
TTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTTGACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCA
CCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCGGGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAA
TTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGTCATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGA
GGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATTAGAGATCAGTGTCTTAGAAAAATACCCCAATACACCCATGAG
TCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCT
TCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGG
GGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGG
TGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGTATCGTCGTCCTCCCCGCAGTCAGGCTGCCCATCACCCACCATTCC
AGCAGGTAAAGTCATTTCTCCATCACAGAAGCACAGCAAGAAGGCACTAAAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCA
GCAATGCAGGCCAAGCATATCCATCTCCTCCAACCAGCATCTCTCACTAAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACC
TGCAACATGGGAAGGAAAGCAATCTGATGGACAGACAGGCAGCCCTCAAAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAA
TACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAGATCTGAGAGACTCCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGA
CGTTGAGACACCGGACTCCATTCTGGTTAATACAAATCTGCGAGCACTGATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCA
GCAACGACTGCTTTTACTACTCCCAGAGGTAGATCGACAGGTTGGTCCAGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGA
ATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAGACTCTCAGAAGGTGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGAT
TGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACAATTCTTTGAAAGCTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAA
GAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAAGAAAACCCCAGCTGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTAT
CAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAAAGAAGAAGCATTGCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCA
AGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGAGCCCCTGCTTTCCTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCAT
CAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAAGCCAGTCACCTCTGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTC
TAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGTTACATCGCCAAGCAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCC
CACAGCAGGAGCGGGTCCACAGGAGACTAATATGAAAGAACCTCTAGCAACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTC
TTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGAGAAGAGGCCACGTGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTC
ACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCAGGTGCGAAAAGTACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCC
GTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTTTCCAGTCTCCATCACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACAT
CAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGCAGCAGCTGCCGCTGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCAT
TCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGGAGAGGGTGGTGAAGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGT
CAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGCAGGAACTGGAAGCAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGAC
TCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCAGGCACAGCCTCATAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCC
TCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGTCCCATCACCAGCCCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAG
AGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACAAGGGCCCAGTAGTTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCT
AATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGATGGCACAGTTGAGCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGC
CTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGTAACTCCCTCCCCTTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCC
TGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGGATCAGCTCCACCCTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGG
AACTTCTTTAAACATGAATGGACCCACTTTAAGACCAACCTCTAGTATCCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAA
AGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCTCACCAAAGTTGAAATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGAT
GGGAGCGCTCATAGCTACCAACACAACAGAAAATAGCACCAGAGAGGAAGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCT
GGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGTTCCAAGGCCCCTTCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGA
CACACACCAATACCACGAAGGACTAAGTAAAGCAACCCAAGATCAGATCCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCT
CTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCACTCAGGTTTCCAGCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTT
TGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGGGCACTACTTACTGAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAG
GACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCTAAGCAGCCCCACTGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAAC
AGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGATGAGGAAAGTACTGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCA
GGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTCAGGACCTCACAGCAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAA
TGTGAAGGCTGAGATACCATTGAATGAGCAAACCACTTTAAGTAAGGAGAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGAC
CCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCAGATGGCTCATGCAGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAG
TTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCACCCACCAGCCCCTACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCC
CACCCAGATAGGGCCAAGCTATAGAGGCATGATCAATGTCTCCACCTCATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGT
ATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGTGACTGTCACTACCATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCA
GACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAGCATAGAGGGCACGCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTG
CAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCATCGGCCCCTCCAAACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAA
AGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTTGACCAGTTGGGTTTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTT
TCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGGAATACAAAGTACAGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAG
TCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAGTTTGCACTTACAAAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTC
CAAGTGTTTAGGTAATAATGTATTACTTTGAATTCAGATTAATGTTCTACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAA
GGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCTAGGAAAAGGAAAGTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTT
GTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTATTCAGCCTTTGCAGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGG
TGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAATTCATTTCACAGGTAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTT
CTACTGTACTAGTTACTAGTTACTGGTACTGTTGCCAAGCAATCTGCTTGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTG
CCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGCCTCTCTGGGACCCCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAA
AAATACCCTATCCCCGCACTTAGTCATTCGTGGTAACTAACAATTTTGAAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGG
TGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGAAACCACAGAAACTGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACA
CTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCCCAACCTGTTAACCTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTC
ACCAATGCCACATTTGTTCATTCTGTTCAACCTGTTTTGACCTCCCAGGCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTA
CACATACGTGTATGTACACACACACACACAATACAAGACATTTTTCCTGTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGA
GCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAATGGCTAAGGGAACATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTT
GCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTTTTTGTTTTTAAATCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTT
AGGTCATGGTTAAGGAACATTAAAATAAACCTGCAGTTTAACAGAATTTTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATAT
TGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTACAAATGTTAATGCAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTG
ATATTTACAAAATGCAGAACAGTTTAAACTTGTTAAGTCACATTCCAGATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCA
TTCTACTACCCACCACTGCCCACCCCACCCCCACATCACACACTCTTCGATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAA
ACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCTTTTTTGTGGCCCAAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCA
GAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCAGCACACACAGCTAAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATAT
TTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATGGTGCTCCCAAATATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCT
GTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAACTCCACCTTAGTGCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGA
GTTTTGGAATTGATTCCATGCTAAATGTCAGTTACCAGTTTGGATTGATGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGG
TTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACAGACTATAACTAGGAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAG
AGCAAACCATATTGTGCCTCTTCATCTTGACCCAGGCTCTTATAGATAGGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAA
TACTCAGCTAAATATTTGCATTTAGGAATACTCCTAAAACAGATATTGCCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAAC
AGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATACCAGTCTATTTATCAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCA
TCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAAAACACATTACAATCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTA
TTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATCTTTACCTTAGTTTTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTA
ATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGCATTATTTCCAGTGACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCA
CCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGTCACCCCAGGAGATAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCT
AAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAATAATTTTGGAGAATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAAT
AGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCCCTATGCTCAAGATACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAA
TAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGAGCATACTTATTGGGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCT
CAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTTCCAGGTGAAGGTGCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGT
TGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCATAAATAACTCTCTGGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGAC
TTCTCTGGTCATTACACTGCTATTTATTTCTAGAACTCACTATCAGTGAGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACA
TCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTACAACTGTGTGCTAAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTAT
AGAATAGTCCAAAGAGACTTTGAGAAACATGGTGATAGGCAGGGGCCTTTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAA
CAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAGCTTCGTAGATTCTTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAAC
TATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAATATATTTTAAGTAATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACT
TTGAATTTCTCATATATGGTATGTTTGATGTAGGACCTCACTGTTAAGGCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGA
TTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTGGGGTTTATTTTTTATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTT
TTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTTGGTAAATGCTAAACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTG
GAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACACCATTTAAAAAGTCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAA
TTTTAAGTATTTGCAATAAATATATGTATATAGATTGTATGTATTCCTATATTCTTATTTTTCATTTTATTATTAAGTAAAAGATCATTA
AAAGTGAAAATAAAAACCTTGGAGTTTTTTGGTGAATCTTGAGGTTTAACATACATCTGAGAGTGGCGTGGGTAAGAGTCCTCAGTTACT
GCCTTATACTCCTATGGGATGGTTCCCACAGATTGTATGGAAGAGAGTAAAATGAGGAACTTGGTGATAAATCAGGGTAGTGTATTTCTT
TTGGAATTTAAGTAAAACTGATTAAATTTTCCTTATCTGTCTGTCTCCATGTTTTCTCCCTTAATCTGTTTTGTCTCCTAACCCCCTAAC
ATTACTGGAAAAGTGAAGAAATGCGGTGCAGCCTCTTTATTAATGTGCCCATTGTTTGCTCCTAAATCAAAGAATGGTAAGGAAATATCT
CGGGGGAAAAAATAGGTTTTCCTTTCTCCACAGTGGTTGACATTTACTGCCACCACTTTCCAGGCCTTAGGGGAGTGTGAAGAAATAGTT
TCTTGAAGATGATAGAAATTTTTTTTTTTCCGTTTCCCAGTTCTCTCAGAAGTGAGTTTCATAGCCAGTCATGTCCTTCCTGCCCGTCTA
ATCTGGAGAGGTCAAAGAGCAAGGAAAATAATGTGAAGAGAAACACCTGTGCCTTGATTAGGTTCTATTTCAGCATTTGACACTTGAATT
TTGAACTCCTCTGGGTCAGGAAGGGTAGCTATGGAAATGAGGTCTGAGCCAGTTGGTAGGAGAGGTTGTCTATGTTCCCATACCGAGATT
GCTGTCTAATCCACGAGAACTCATTTTGTGGCTGCAAAGTAAATACTTGATTTTAGGATATGATAGGAGCAAAATGGTGCCTACATCGTC
TTTATAAAGAAAAGTATATAGCCCATTTTTTAACAAATGAATAATATATCGAATCATTGATGACCTAAAAGAAAAATTGTTAAGGTCAGA
TTTTCGAGAGTGTATCTTGATGACCCATAAAACTGACTTTTTATTGTAGTTCACTAGTTCCCATAATTGCCCAGCTGTGGTTACTTTCAC
TGAAAAGAAAAAATATATTTTGGAAGTTAATGTAAGGATACATTGGCTTTTTTTTTTTTTCTTTACATTGGCTTTTTAAAAGACAGTTTT
TATTTTTCAGATACTGGAATGTCAAGTATCTGGGTTGTCCCAAGACGTTGGAGATAATTCAGCCTTCCAAGAGAACAGCAGTCTAGATCT
TAGCTGAAAATGTGCTGTTTCTAAAGGAAGCTTCTTAAGTCTCAGGGGACATTAGCATCTTCATAATTTCCATATATAATAAGAATGAAG
GTAAAATATTTAAATGTGTATAAACTAATCCATAATGACCATTTACAAAGATTGACTCCCCATTTCTGGTACATATTTATCATTATTTAG
ATGGGTCTCCTATCTTGTGGGAAGATAAATTTATATTCAGGTGATGACATGGGTGCCTGCAAGTAGAGTTGGTCTGCAGCTGAGGGAGAA
GGCAACATACCAGAAGACAAGGCAGCTTCAACCTGGATCCCCAGCTACCCTTTATTTACTTCACTGAGTCAGAAACCCGTGTTCATTGCT
TCTGAGACTACTTGACCTCAGCTGGTCTTTAGAAGTCTGGTAACTTTTTATGTACAAATCATGTTATTTACTAATTCAAGTATTTATAGA
GCACCTACTGTGCACTAAGCACTAAAGTGCTGGTTATGCAAAGGTAAGCAAAAATAGTCATGTAAGTTGCAGAAAGGTTTTCCTAAAGTA
GTGACTATACAGCATGTTTTTAGTTCTAGGCTCAAGGAGTAATACTACCTTTTTCCCAAGATAGGTTGAAAATTTAAATGAGTTATGAAA
TGGAAGTGTTTGAGACACTGGACACAGTAGTGGCAAATACATGAAGAAAGAAGGTCCCTAGATGAAAAAAGTGTGGAAATGAGGAGCCAT
ATTAATAAAATGCACCTTTTTTGAGAACTATTGTTGGAATAGCTAAAGTTGTCTATAGAAATTTCAAGAAATCTCTTAACATCTAAATTA
GAAGCAGGCCAACAGCAATCTCTGTCAGTAGTTAATTTAGGTCAGTAAGTTAGTGTTTTGTTAAACTAACCCTTTCAAACACAGTTGGGT
AAATAATGCAGCTTTCCTGTCACTGTTCAAACCTAAAAGAAGCTAAAGGGAATTTTTCTTAAAACATGATTTTCATCTTATAGATGATAA
GTAACTGTATCTCTTCATTTGGAATTGTTGCATCCCAGTTTTTCTCCATAATGGATAAAATTACTTTTGTGTCCTTTTCTATTCTAATGT
AGAAGTGGCTTTTCCTTTTTTCTCTTGAGTCACAACTTGAATTAAAAAGGGCTTCAGCAGGACTCTAGCGCTTTTTAAAGAAGAATTTGG
TGTATTCCACTATGTAACGTAGTCTCTGTCCAGGAACCAGGAGGATGAGTGTCCTCAGTTTTCCTAATACTTGGTAACATTTAATAATAG
ATTGAGTTTTGCTTTTGTTTTTCATAGAGACTGTATAGACTCTGTACTTCCATGTAACTTTCTGCCTTAACCTAAAAAGGCATTCCCTGG
AAGGAGATCTTGTAACAGGAAGAAAAAGCGAAACCAGGAAAAGAGCCAGAAAGGATCAACTTGGAGATGGGCTGTGGCTAAATAGTGGGT
TTTCCTGAAAAGTAACTGCAACCTTGCTTTTCGTGCTTCTTCAAACCCAAAAGAACCTAAAGGGAATTTTTAAAAATCCTGATTTTCTTC
TTAATTGTAAAACCTAGAGGATGCCTTAGGGAGAAGAAAGATAACCTGGAATTTGGTTTTAAATGGATTTAAGTAAACTTTGAATTAAGT
AGCTTATTCCATTTTTGAGAGATTTCTTTTTAAGATTTTAGATTCACTTAATGTAATGTTGAATTGCCATGAATGTAACCTGGAGTTTGA
TTTGAGACATTCTGTGGGATAAGGAATAGTTTTCTATTGAACTGTGGTGGCTTTTGCCACTAATCAGGATTTAGGGCTGTGCACCTCCAT
CTGTTAAGTGAAATGGAACTTGGCTTCCTAAACACTATATTAGACCAACTTGAGTCAATACTTTTATTAAGTTTAATCAGGGATTCTCAA
AATATTTAGGATTCAAATTAGCCCAATTAGAAAGCAGTGCATTAAATGTTACCAAAATATCTGAAGATACTTTAGAACTATTTTACACAA
AGCTTATGTCTTTCCTATGGAAAGTATCATACATAAAATTTTACATTCTTTTAAAAAACAGAATCTAATGTCTTCAGATACCTAGAGCTT
GGAAATTATAATAGAGTTGGGCTTTGACCCGAAGTCAGCAGTTCTTTTCATTTTAGATTTTCAGGCAAGTTTCAGTAGTTTGGAGACTTC
TTCAGTAGTGACCCCAGCTTAACCTACATATAATCACTTTGCACACATTTTAAGTTAATCAGATGCTTCCAGAGTCTTGGATTTGGTTAC
CCCTTTGTTAGATAAGGAGACAGATTCTAGGTTGGGACAAACATCTTAATTTATTCTCTAATAATAAAGTACTGATTAAAGAGCAAGTTC
TCAGAGAATTCACAAAATTTCTAGAATCCATGAAAGATCTAGAGAACATAACAAATGAAACTCTAGAAATTTGAAAGAAAAAAAAACACT
TAGCTGTAAGTGCTTTGACCTATTTTTTTTAAAAAAAAAAAACCTGTCTTAATTCTGTGACTGCATTGCACCCTTCACCAGCACTAAGAG
AAGTCGGAATGGAAGAAATTACCGTATGTAATTCTTATTCACTTAAAATCTTTGTGCGCATAGGCCTTAGCACTTTGACAAATAAACTCT
GCCTTTTAGCTCCTCACTATTGTCTTCTTTCCTGTCACTTTTAGGCTGTTTCATTGGTCGTATAAAAACAACCTTCTTCGAAGTTGAATG

>41198_41198_1_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000265713_ASXL2_chr2_26068436_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

--------------------------------------------------------------
>41198_41198_2_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000396930_ASXL2_chr2_26068436_ENST00000435504_length(transcript)=15507nt_BP=2980nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGTGAG
CAGAGATTGCGGAGTACAGAATAGCCATCACCCACTCTGGCATAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGA
GTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTT
GGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTT
CCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTT
CACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGA
AGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAAC
AATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGG
AAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAA
AAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATT
GGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAA
AGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTG
TAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCC
ATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCG
AGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCG
TATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACG
GCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGG
CCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGG
CTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCC
TTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCAC
TTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGA
GAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCC
CTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCT
TTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCTGCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGA
GATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGGGAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTT
GTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATTTCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGT
TGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAATGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGG
CAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGAAGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCT
TTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCTTTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTT
GACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCACCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCG
GGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAATTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGT
CATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGAGGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATT
AGAGATCAGTGTCTTAGAAAAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAAT
CAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGG
TAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTC
AGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGTATC
GTCGTCCTCCCCGCAGTCAGGCTGCCCATCACCCACCATTCCAGCAGGTAAAGTCATTTCTCCATCACAGAAGCACAGCAAGAAGGCACT
AAAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCAGCAATGCAGGCCAAGCATATCCATCTCCTCCAACCAGCATCTCTCACT
AAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACCTGCAACATGGGAAGGAAAGCAATCTGATGGACAGACAGGCAGCCCTCA
AAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAATACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAGATCTGAGAGACT
CCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGACGTTGAGACACCGGACTCCATTCTGGTTAATACAAATCTGCGAGCACT
GATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCAGCAACGACTGCTTTTACTACTCCCAGAGGTAGATCGACAGGTTGGTCC
AGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGAATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAGACTCTCAGAAGG
TGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGATTGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACAATTCTTTGAAAG
CTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAAGAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAAGAAAACCCCAGC
TGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTATCAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAAAGAAGAAGCATT
GCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCAAGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGAGCCCCTGCTTTC
CTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCATCAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAAGCCAGTCACCTC
TGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTCTAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGTTACATCGCCAAG
CAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCCCACAGCAGGAGCGGGTCCACAGGAGACTAATATGAAAGAACCTCTAGC
AACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTCTTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGAGAAGAGGCCACG
TGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTCACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCAGGTGCGAAAAGT
ACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCCGTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTTTCCAGTCTCCAT
CACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACATCAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGCAGCAGCTGCCGC
TGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCATTCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGGAGAGGGTGGTGA
AGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGTCAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGCAGGAACTGGAAG
CAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGACTCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCAGGCACAGCCTCA
TAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCCTCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGTCCCATCACCAGC
CCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAGAGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACAAGGGCCCAGTAG
TTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCTAATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGATGGCACAGTTGA
GCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGCCTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGTAACTCCCTCCCC
TTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCCTGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGGATCAGCTCCACC
CTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGGAACTTCTTTAAACATGAATGGACCCACTTTAAGACCAACCTCTAGTAT
CCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAAAGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCTCACCAAAGTTGA
AATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGATGGGAGCGCTCATAGCTACCAACACAACAGAAAATAGCACCAGAGAGGA
AGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCTGGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGTTCCAAGGCCCCT
TCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGACACACACCAATACCACGAAGGACTAAGTAAAGCAACCCAAGATCAGAT
CCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCTCTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCACTCAGGTTTCCA
GCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTTTGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGGGCACTACTTACT
GAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAGGACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCTAAGCAGCCCCAC
TGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAACAGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGATGAGGAAAGTAC
TGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCAGGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTCAGGACCTCACAG
CAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAATGTGAAGGCTGAGATACCATTGAATGAGCAAACCACTTTAAGTAAGGA
GAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGACCCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCAGATGGCTCATGC
AGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAGTTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCACCCACCAGCCCCT
ACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCCCACCCAGATAGGGCCAAGCTATAGAGGCATGATCAATGTCTCCACCTC
ATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGTATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGTGACTGTCACTAC
CATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCAGACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAGCATAGAGGGCAC
GCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTGCAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCATCGGCCCCTCCAA
ACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAAAGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTTGACCAGTTGGGT
TTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTTTCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGGAATACAAAGTAC
AGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAGTCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAGTTTGCACTTACA
AAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTCCAAGTGTTTAGGTAATAATGTATTACTTTGAATTCAGATTAATGTTCT
ACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAAGGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCTAGGAAAAGGAAA
GTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTTGTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTATTCAGCCTTTGC
AGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGGTGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAATTCATTTCACAGG
TAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTTCTACTGTACTAGTTACTAGTTACTGGTACTGTTGCCAAGCAATCTGCT
TGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTGCCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGCCTCTCTGGGACC
CCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAAAAATACCCTATCCCCGCACTTAGTCATTCGTGGTAACTAACAATTTTG
AAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGGTGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGAAACCACAGAAAC
TGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACACTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCCCAACCTGTTAAC
CTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTCACCAATGCCACATTTGTTCATTCTGTTCAACCTGTTTTGACCTCCCAG
GCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTACACATACGTGTATGTACACACACACACACAATACAAGACATTTTTCCT
GTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGAGCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAATGGCTAAGGGAAC
ATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTTGCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTTTTTGTTTTTAAA
TCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTTAGGTCATGGTTAAGGAACATTAAAATAAACCTGCAGTTTAACAGAATT
TTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATATTGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTACAAATGTTAATG
CAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTGATATTTACAAAATGCAGAACAGTTTAAACTTGTTAAGTCACATTCCAG
ATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCATTCTACTACCCACCACTGCCCACCCCACCCCCACATCACACACTCTTC
GATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAAACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCTTTTTTGTGGCCC
AAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCAGAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCAGCACACACAGCT
AAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATATTTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATGGTGCTCCCAAAT
ATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCTGTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAACTCCACCTTAGT
GCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGAGTTTTGGAATTGATTCCATGCTAAATGTCAGTTACCAGTTTGGATTGA
TGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGGTTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACAGACTATAACTAG
GAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAGAGCAAACCATATTGTGCCTCTTCATCTTGACCCAGGCTCTTATAGATA
GGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAATACTCAGCTAAATATTTGCATTTAGGAATACTCCTAAAACAGATATTG
CCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAACAGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATACCAGTCTATTTAT
CAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCATCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAAAACACATTACAA
TCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTATTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATCTTTACCTTAGTT
TTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTAATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGCATTATTTCCAGT
GACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCACCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGTCACCCCAGGAGA
TAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCTAAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAATAATTTTGGAGA
ATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAATAGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCCCTATGCTCAAGA
TACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAATAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGAGCATACTTATTG
GGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCTCAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTTCCAGGTGAAGGT
GCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGTTGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCATAAATAACTCTCT
GGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGACTTCTCTGGTCATTACACTGCTATTTATTTCTAGAACTCACTATCAGTG
AGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACATCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTACAACTGTGTGCT
AAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTATAGAATAGTCCAAAGAGACTTTGAGAAACATGGTGATAGGCAGGGGCCT
TTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAACAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAGCTTCGTAGATTC
TTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAACTATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAATATATTTTAAGT
AATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACTTTGAATTTCTCATATATGGTATGTTTGATGTAGGACCTCACTGTTAAG
GCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGATTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTGGGGTTTATTTTT
TATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTTTTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTTGGTAAATGCTAA
ACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTGGAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACACCATTTAAAAAG
TCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAATTTTAAGTATTTGCAATAAATATATGTATATAGATTGTATGTATTCCT
ATATTCTTATTTTTCATTTTATTATTAAGTAAAAGATCATTAAAAGTGAAAATAAAAACCTTGGAGTTTTTTGGTGAATCTTGAGGTTTA
ACATACATCTGAGAGTGGCGTGGGTAAGAGTCCTCAGTTACTGCCTTATACTCCTATGGGATGGTTCCCACAGATTGTATGGAAGAGAGT
AAAATGAGGAACTTGGTGATAAATCAGGGTAGTGTATTTCTTTTGGAATTTAAGTAAAACTGATTAAATTTTCCTTATCTGTCTGTCTCC
ATGTTTTCTCCCTTAATCTGTTTTGTCTCCTAACCCCCTAACATTACTGGAAAAGTGAAGAAATGCGGTGCAGCCTCTTTATTAATGTGC
CCATTGTTTGCTCCTAAATCAAAGAATGGTAAGGAAATATCTCGGGGGAAAAAATAGGTTTTCCTTTCTCCACAGTGGTTGACATTTACT
GCCACCACTTTCCAGGCCTTAGGGGAGTGTGAAGAAATAGTTTCTTGAAGATGATAGAAATTTTTTTTTTTCCGTTTCCCAGTTCTCTCA
GAAGTGAGTTTCATAGCCAGTCATGTCCTTCCTGCCCGTCTAATCTGGAGAGGTCAAAGAGCAAGGAAAATAATGTGAAGAGAAACACCT
GTGCCTTGATTAGGTTCTATTTCAGCATTTGACACTTGAATTTTGAACTCCTCTGGGTCAGGAAGGGTAGCTATGGAAATGAGGTCTGAG
CCAGTTGGTAGGAGAGGTTGTCTATGTTCCCATACCGAGATTGCTGTCTAATCCACGAGAACTCATTTTGTGGCTGCAAAGTAAATACTT
GATTTTAGGATATGATAGGAGCAAAATGGTGCCTACATCGTCTTTATAAAGAAAAGTATATAGCCCATTTTTTAACAAATGAATAATATA
TCGAATCATTGATGACCTAAAAGAAAAATTGTTAAGGTCAGATTTTCGAGAGTGTATCTTGATGACCCATAAAACTGACTTTTTATTGTA
GTTCACTAGTTCCCATAATTGCCCAGCTGTGGTTACTTTCACTGAAAAGAAAAAATATATTTTGGAAGTTAATGTAAGGATACATTGGCT
TTTTTTTTTTTTCTTTACATTGGCTTTTTAAAAGACAGTTTTTATTTTTCAGATACTGGAATGTCAAGTATCTGGGTTGTCCCAAGACGT
TGGAGATAATTCAGCCTTCCAAGAGAACAGCAGTCTAGATCTTAGCTGAAAATGTGCTGTTTCTAAAGGAAGCTTCTTAAGTCTCAGGGG
ACATTAGCATCTTCATAATTTCCATATATAATAAGAATGAAGGTAAAATATTTAAATGTGTATAAACTAATCCATAATGACCATTTACAA
AGATTGACTCCCCATTTCTGGTACATATTTATCATTATTTAGATGGGTCTCCTATCTTGTGGGAAGATAAATTTATATTCAGGTGATGAC
ATGGGTGCCTGCAAGTAGAGTTGGTCTGCAGCTGAGGGAGAAGGCAACATACCAGAAGACAAGGCAGCTTCAACCTGGATCCCCAGCTAC
CCTTTATTTACTTCACTGAGTCAGAAACCCGTGTTCATTGCTTCTGAGACTACTTGACCTCAGCTGGTCTTTAGAAGTCTGGTAACTTTT
TATGTACAAATCATGTTATTTACTAATTCAAGTATTTATAGAGCACCTACTGTGCACTAAGCACTAAAGTGCTGGTTATGCAAAGGTAAG
CAAAAATAGTCATGTAAGTTGCAGAAAGGTTTTCCTAAAGTAGTGACTATACAGCATGTTTTTAGTTCTAGGCTCAAGGAGTAATACTAC
CTTTTTCCCAAGATAGGTTGAAAATTTAAATGAGTTATGAAATGGAAGTGTTTGAGACACTGGACACAGTAGTGGCAAATACATGAAGAA
AGAAGGTCCCTAGATGAAAAAAGTGTGGAAATGAGGAGCCATATTAATAAAATGCACCTTTTTTGAGAACTATTGTTGGAATAGCTAAAG
TTGTCTATAGAAATTTCAAGAAATCTCTTAACATCTAAATTAGAAGCAGGCCAACAGCAATCTCTGTCAGTAGTTAATTTAGGTCAGTAA
GTTAGTGTTTTGTTAAACTAACCCTTTCAAACACAGTTGGGTAAATAATGCAGCTTTCCTGTCACTGTTCAAACCTAAAAGAAGCTAAAG
GGAATTTTTCTTAAAACATGATTTTCATCTTATAGATGATAAGTAACTGTATCTCTTCATTTGGAATTGTTGCATCCCAGTTTTTCTCCA
TAATGGATAAAATTACTTTTGTGTCCTTTTCTATTCTAATGTAGAAGTGGCTTTTCCTTTTTTCTCTTGAGTCACAACTTGAATTAAAAA
GGGCTTCAGCAGGACTCTAGCGCTTTTTAAAGAAGAATTTGGTGTATTCCACTATGTAACGTAGTCTCTGTCCAGGAACCAGGAGGATGA
GTGTCCTCAGTTTTCCTAATACTTGGTAACATTTAATAATAGATTGAGTTTTGCTTTTGTTTTTCATAGAGACTGTATAGACTCTGTACT
TCCATGTAACTTTCTGCCTTAACCTAAAAAGGCATTCCCTGGAAGGAGATCTTGTAACAGGAAGAAAAAGCGAAACCAGGAAAAGAGCCA
GAAAGGATCAACTTGGAGATGGGCTGTGGCTAAATAGTGGGTTTTCCTGAAAAGTAACTGCAACCTTGCTTTTCGTGCTTCTTCAAACCC
AAAAGAACCTAAAGGGAATTTTTAAAAATCCTGATTTTCTTCTTAATTGTAAAACCTAGAGGATGCCTTAGGGAGAAGAAAGATAACCTG
GAATTTGGTTTTAAATGGATTTAAGTAAACTTTGAATTAAGTAGCTTATTCCATTTTTGAGAGATTTCTTTTTAAGATTTTAGATTCACT
TAATGTAATGTTGAATTGCCATGAATGTAACCTGGAGTTTGATTTGAGACATTCTGTGGGATAAGGAATAGTTTTCTATTGAACTGTGGT
GGCTTTTGCCACTAATCAGGATTTAGGGCTGTGCACCTCCATCTGTTAAGTGAAATGGAACTTGGCTTCCTAAACACTATATTAGACCAA
CTTGAGTCAATACTTTTATTAAGTTTAATCAGGGATTCTCAAAATATTTAGGATTCAAATTAGCCCAATTAGAAAGCAGTGCATTAAATG
TTACCAAAATATCTGAAGATACTTTAGAACTATTTTACACAAAGCTTATGTCTTTCCTATGGAAAGTATCATACATAAAATTTTACATTC
TTTTAAAAAACAGAATCTAATGTCTTCAGATACCTAGAGCTTGGAAATTATAATAGAGTTGGGCTTTGACCCGAAGTCAGCAGTTCTTTT
CATTTTAGATTTTCAGGCAAGTTTCAGTAGTTTGGAGACTTCTTCAGTAGTGACCCCAGCTTAACCTACATATAATCACTTTGCACACAT
TTTAAGTTAATCAGATGCTTCCAGAGTCTTGGATTTGGTTACCCCTTTGTTAGATAAGGAGACAGATTCTAGGTTGGGACAAACATCTTA
ATTTATTCTCTAATAATAAAGTACTGATTAAAGAGCAAGTTCTCAGAGAATTCACAAAATTTCTAGAATCCATGAAAGATCTAGAGAACA
TAACAAATGAAACTCTAGAAATTTGAAAGAAAAAAAAACACTTAGCTGTAAGTGCTTTGACCTATTTTTTTTAAAAAAAAAAAACCTGTC
TTAATTCTGTGACTGCATTGCACCCTTCACCAGCACTAAGAGAAGTCGGAATGGAAGAAATTACCGTATGTAATTCTTATTCACTTAAAA
TCTTTGTGCGCATAGGCCTTAGCACTTTGACAAATAAACTCTGCCTTTTAGCTCCTCACTATTGTCTTCTTTCCTGTCACTTTTAGGCTG
TTTCATTGGTCGTATAAAAACAACCTTCTTCGAAGTTGAATGTATGTTTCTGCACATAGACAAACCATATTTTACTGACTCATTCTATGT

>41198_41198_2_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000396930_ASXL2_chr2_26068436_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

--------------------------------------------------------------
>41198_41198_3_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000265713_ASXL2_chr2_26068432_ENST00000435504_length(transcript)=15375nt_BP=2848nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGCA
TAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTG
AGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAA
GGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTAC
TCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGAT
TTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGA
TCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGA
TCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGAT
AAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGC
ATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGA
TGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCT
TCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAA
GCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAA
GGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTC
ATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAG
GAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAA
GAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCA
ATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAA
CAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTA
CTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAA
ACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACT
GCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTA
CTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCTTTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCT
GCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGAGATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGG
GAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTTGTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATT
TCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGTTGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAA
TGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGGCAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGA
AGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCTTTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCT
TTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTTGACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCA
CCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCGGGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAA
TTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGTCATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGA
GGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATTAGAGATCAGTGTCTTAGAAAAATACCCCAATACACCCATGAG
TCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCT
TCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGG
GGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGG
TGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGTATCGTCGTCCTCCCCGCAGTCAGGCTGCCCATCACCCACCATTCC
AGCAGGTAAAGTCATTTCTCCATCACAGAAGCACAGCAAGAAGGCACTAAAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCA
GCAATGCAGGCCAAGCATATCCATCTCCTCCAACCAGCATCTCTCACTAAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACC
TGCAACATGGGAAGGAAAGCAATCTGATGGACAGACAGGCAGCCCTCAAAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAA
TACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAGATCTGAGAGACTCCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGA
CGTTGAGACACCGGACTCCATTCTGGTTAATACAAATCTGCGAGCACTGATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCA
GCAACGACTGCTTTTACTACTCCCAGAGGTAGATCGACAGGTTGGTCCAGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGA
ATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAGACTCTCAGAAGGTGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGAT
TGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACAATTCTTTGAAAGCTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAA
GAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAAGAAAACCCCAGCTGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTAT
CAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAAAGAAGAAGCATTGCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCA
AGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGAGCCCCTGCTTTCCTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCAT
CAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAAGCCAGTCACCTCTGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTC
TAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGTTACATCGCCAAGCAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCC
CACAGCAGGAGCGGGTCCACAGGAGACTAATATGAAAGAACCTCTAGCAACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTC
TTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGAGAAGAGGCCACGTGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTC
ACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCAGGTGCGAAAAGTACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCC
GTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTTTCCAGTCTCCATCACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACAT
CAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGCAGCAGCTGCCGCTGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCAT
TCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGGAGAGGGTGGTGAAGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGT
CAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGCAGGAACTGGAAGCAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGAC
TCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCAGGCACAGCCTCATAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCC
TCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGTCCCATCACCAGCCCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAG
AGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACAAGGGCCCAGTAGTTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCT
AATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGATGGCACAGTTGAGCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGC
CTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGTAACTCCCTCCCCTTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCC
TGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGGATCAGCTCCACCCTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGG
AACTTCTTTAAACATGAATGGACCCACTTTAAGACCAACCTCTAGTATCCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAA
AGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCTCACCAAAGTTGAAATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGAT
GGGAGCGCTCATAGCTACCAACACAACAGAAAATAGCACCAGAGAGGAAGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCT
GGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGTTCCAAGGCCCCTTCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGA
CACACACCAATACCACGAAGGACTAAGTAAAGCAACCCAAGATCAGATCCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCT
CTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCACTCAGGTTTCCAGCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTT
TGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGGGCACTACTTACTGAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAG
GACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCTAAGCAGCCCCACTGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAAC
AGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGATGAGGAAAGTACTGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCA
GGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTCAGGACCTCACAGCAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAA
TGTGAAGGCTGAGATACCATTGAATGAGCAAACCACTTTAAGTAAGGAGAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGAC
CCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCAGATGGCTCATGCAGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAG
TTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCACCCACCAGCCCCTACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCC
CACCCAGATAGGGCCAAGCTATAGAGGCATGATCAATGTCTCCACCTCATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGT
ATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGTGACTGTCACTACCATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCA
GACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAGCATAGAGGGCACGCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTG
CAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCATCGGCCCCTCCAAACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAA
AGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTTGACCAGTTGGGTTTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTT
TCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGGAATACAAAGTACAGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAG
TCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAGTTTGCACTTACAAAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTC
CAAGTGTTTAGGTAATAATGTATTACTTTGAATTCAGATTAATGTTCTACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAA
GGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCTAGGAAAAGGAAAGTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTT
GTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTATTCAGCCTTTGCAGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGG
TGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAATTCATTTCACAGGTAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTT
CTACTGTACTAGTTACTAGTTACTGGTACTGTTGCCAAGCAATCTGCTTGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTG
CCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGCCTCTCTGGGACCCCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAA
AAATACCCTATCCCCGCACTTAGTCATTCGTGGTAACTAACAATTTTGAAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGG
TGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGAAACCACAGAAACTGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACA
CTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCCCAACCTGTTAACCTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTC
ACCAATGCCACATTTGTTCATTCTGTTCAACCTGTTTTGACCTCCCAGGCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTA
CACATACGTGTATGTACACACACACACACAATACAAGACATTTTTCCTGTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGA
GCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAATGGCTAAGGGAACATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTT
GCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTTTTTGTTTTTAAATCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTT
AGGTCATGGTTAAGGAACATTAAAATAAACCTGCAGTTTAACAGAATTTTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATAT
TGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTACAAATGTTAATGCAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTG
ATATTTACAAAATGCAGAACAGTTTAAACTTGTTAAGTCACATTCCAGATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCA
TTCTACTACCCACCACTGCCCACCCCACCCCCACATCACACACTCTTCGATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAA
ACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCTTTTTTGTGGCCCAAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCA
GAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCAGCACACACAGCTAAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATAT
TTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATGGTGCTCCCAAATATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCT
GTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAACTCCACCTTAGTGCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGA
GTTTTGGAATTGATTCCATGCTAAATGTCAGTTACCAGTTTGGATTGATGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGG
TTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACAGACTATAACTAGGAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAG
AGCAAACCATATTGTGCCTCTTCATCTTGACCCAGGCTCTTATAGATAGGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAA
TACTCAGCTAAATATTTGCATTTAGGAATACTCCTAAAACAGATATTGCCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAAC
AGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATACCAGTCTATTTATCAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCA
TCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAAAACACATTACAATCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTA
TTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATCTTTACCTTAGTTTTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTA
ATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGCATTATTTCCAGTGACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCA
CCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGTCACCCCAGGAGATAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCT
AAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAATAATTTTGGAGAATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAAT
AGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCCCTATGCTCAAGATACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAA
TAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGAGCATACTTATTGGGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCT
CAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTTCCAGGTGAAGGTGCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGT
TGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCATAAATAACTCTCTGGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGAC
TTCTCTGGTCATTACACTGCTATTTATTTCTAGAACTCACTATCAGTGAGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACA
TCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTACAACTGTGTGCTAAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTAT
AGAATAGTCCAAAGAGACTTTGAGAAACATGGTGATAGGCAGGGGCCTTTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAA
CAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAGCTTCGTAGATTCTTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAAC
TATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAATATATTTTAAGTAATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACT
TTGAATTTCTCATATATGGTATGTTTGATGTAGGACCTCACTGTTAAGGCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGA
TTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTGGGGTTTATTTTTTATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTT
TTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTTGGTAAATGCTAAACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTG
GAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACACCATTTAAAAAGTCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAA
TTTTAAGTATTTGCAATAAATATATGTATATAGATTGTATGTATTCCTATATTCTTATTTTTCATTTTATTATTAAGTAAAAGATCATTA
AAAGTGAAAATAAAAACCTTGGAGTTTTTTGGTGAATCTTGAGGTTTAACATACATCTGAGAGTGGCGTGGGTAAGAGTCCTCAGTTACT
GCCTTATACTCCTATGGGATGGTTCCCACAGATTGTATGGAAGAGAGTAAAATGAGGAACTTGGTGATAAATCAGGGTAGTGTATTTCTT
TTGGAATTTAAGTAAAACTGATTAAATTTTCCTTATCTGTCTGTCTCCATGTTTTCTCCCTTAATCTGTTTTGTCTCCTAACCCCCTAAC
ATTACTGGAAAAGTGAAGAAATGCGGTGCAGCCTCTTTATTAATGTGCCCATTGTTTGCTCCTAAATCAAAGAATGGTAAGGAAATATCT
CGGGGGAAAAAATAGGTTTTCCTTTCTCCACAGTGGTTGACATTTACTGCCACCACTTTCCAGGCCTTAGGGGAGTGTGAAGAAATAGTT
TCTTGAAGATGATAGAAATTTTTTTTTTTCCGTTTCCCAGTTCTCTCAGAAGTGAGTTTCATAGCCAGTCATGTCCTTCCTGCCCGTCTA
ATCTGGAGAGGTCAAAGAGCAAGGAAAATAATGTGAAGAGAAACACCTGTGCCTTGATTAGGTTCTATTTCAGCATTTGACACTTGAATT
TTGAACTCCTCTGGGTCAGGAAGGGTAGCTATGGAAATGAGGTCTGAGCCAGTTGGTAGGAGAGGTTGTCTATGTTCCCATACCGAGATT
GCTGTCTAATCCACGAGAACTCATTTTGTGGCTGCAAAGTAAATACTTGATTTTAGGATATGATAGGAGCAAAATGGTGCCTACATCGTC
TTTATAAAGAAAAGTATATAGCCCATTTTTTAACAAATGAATAATATATCGAATCATTGATGACCTAAAAGAAAAATTGTTAAGGTCAGA
TTTTCGAGAGTGTATCTTGATGACCCATAAAACTGACTTTTTATTGTAGTTCACTAGTTCCCATAATTGCCCAGCTGTGGTTACTTTCAC
TGAAAAGAAAAAATATATTTTGGAAGTTAATGTAAGGATACATTGGCTTTTTTTTTTTTTCTTTACATTGGCTTTTTAAAAGACAGTTTT
TATTTTTCAGATACTGGAATGTCAAGTATCTGGGTTGTCCCAAGACGTTGGAGATAATTCAGCCTTCCAAGAGAACAGCAGTCTAGATCT
TAGCTGAAAATGTGCTGTTTCTAAAGGAAGCTTCTTAAGTCTCAGGGGACATTAGCATCTTCATAATTTCCATATATAATAAGAATGAAG
GTAAAATATTTAAATGTGTATAAACTAATCCATAATGACCATTTACAAAGATTGACTCCCCATTTCTGGTACATATTTATCATTATTTAG
ATGGGTCTCCTATCTTGTGGGAAGATAAATTTATATTCAGGTGATGACATGGGTGCCTGCAAGTAGAGTTGGTCTGCAGCTGAGGGAGAA
GGCAACATACCAGAAGACAAGGCAGCTTCAACCTGGATCCCCAGCTACCCTTTATTTACTTCACTGAGTCAGAAACCCGTGTTCATTGCT
TCTGAGACTACTTGACCTCAGCTGGTCTTTAGAAGTCTGGTAACTTTTTATGTACAAATCATGTTATTTACTAATTCAAGTATTTATAGA
GCACCTACTGTGCACTAAGCACTAAAGTGCTGGTTATGCAAAGGTAAGCAAAAATAGTCATGTAAGTTGCAGAAAGGTTTTCCTAAAGTA
GTGACTATACAGCATGTTTTTAGTTCTAGGCTCAAGGAGTAATACTACCTTTTTCCCAAGATAGGTTGAAAATTTAAATGAGTTATGAAA
TGGAAGTGTTTGAGACACTGGACACAGTAGTGGCAAATACATGAAGAAAGAAGGTCCCTAGATGAAAAAAGTGTGGAAATGAGGAGCCAT
ATTAATAAAATGCACCTTTTTTGAGAACTATTGTTGGAATAGCTAAAGTTGTCTATAGAAATTTCAAGAAATCTCTTAACATCTAAATTA
GAAGCAGGCCAACAGCAATCTCTGTCAGTAGTTAATTTAGGTCAGTAAGTTAGTGTTTTGTTAAACTAACCCTTTCAAACACAGTTGGGT
AAATAATGCAGCTTTCCTGTCACTGTTCAAACCTAAAAGAAGCTAAAGGGAATTTTTCTTAAAACATGATTTTCATCTTATAGATGATAA
GTAACTGTATCTCTTCATTTGGAATTGTTGCATCCCAGTTTTTCTCCATAATGGATAAAATTACTTTTGTGTCCTTTTCTATTCTAATGT
AGAAGTGGCTTTTCCTTTTTTCTCTTGAGTCACAACTTGAATTAAAAAGGGCTTCAGCAGGACTCTAGCGCTTTTTAAAGAAGAATTTGG
TGTATTCCACTATGTAACGTAGTCTCTGTCCAGGAACCAGGAGGATGAGTGTCCTCAGTTTTCCTAATACTTGGTAACATTTAATAATAG
ATTGAGTTTTGCTTTTGTTTTTCATAGAGACTGTATAGACTCTGTACTTCCATGTAACTTTCTGCCTTAACCTAAAAAGGCATTCCCTGG
AAGGAGATCTTGTAACAGGAAGAAAAAGCGAAACCAGGAAAAGAGCCAGAAAGGATCAACTTGGAGATGGGCTGTGGCTAAATAGTGGGT
TTTCCTGAAAAGTAACTGCAACCTTGCTTTTCGTGCTTCTTCAAACCCAAAAGAACCTAAAGGGAATTTTTAAAAATCCTGATTTTCTTC
TTAATTGTAAAACCTAGAGGATGCCTTAGGGAGAAGAAAGATAACCTGGAATTTGGTTTTAAATGGATTTAAGTAAACTTTGAATTAAGT
AGCTTATTCCATTTTTGAGAGATTTCTTTTTAAGATTTTAGATTCACTTAATGTAATGTTGAATTGCCATGAATGTAACCTGGAGTTTGA
TTTGAGACATTCTGTGGGATAAGGAATAGTTTTCTATTGAACTGTGGTGGCTTTTGCCACTAATCAGGATTTAGGGCTGTGCACCTCCAT
CTGTTAAGTGAAATGGAACTTGGCTTCCTAAACACTATATTAGACCAACTTGAGTCAATACTTTTATTAAGTTTAATCAGGGATTCTCAA
AATATTTAGGATTCAAATTAGCCCAATTAGAAAGCAGTGCATTAAATGTTACCAAAATATCTGAAGATACTTTAGAACTATTTTACACAA
AGCTTATGTCTTTCCTATGGAAAGTATCATACATAAAATTTTACATTCTTTTAAAAAACAGAATCTAATGTCTTCAGATACCTAGAGCTT
GGAAATTATAATAGAGTTGGGCTTTGACCCGAAGTCAGCAGTTCTTTTCATTTTAGATTTTCAGGCAAGTTTCAGTAGTTTGGAGACTTC
TTCAGTAGTGACCCCAGCTTAACCTACATATAATCACTTTGCACACATTTTAAGTTAATCAGATGCTTCCAGAGTCTTGGATTTGGTTAC
CCCTTTGTTAGATAAGGAGACAGATTCTAGGTTGGGACAAACATCTTAATTTATTCTCTAATAATAAAGTACTGATTAAAGAGCAAGTTC
TCAGAGAATTCACAAAATTTCTAGAATCCATGAAAGATCTAGAGAACATAACAAATGAAACTCTAGAAATTTGAAAGAAAAAAAAACACT
TAGCTGTAAGTGCTTTGACCTATTTTTTTTAAAAAAAAAAAACCTGTCTTAATTCTGTGACTGCATTGCACCCTTCACCAGCACTAAGAG
AAGTCGGAATGGAAGAAATTACCGTATGTAATTCTTATTCACTTAAAATCTTTGTGCGCATAGGCCTTAGCACTTTGACAAATAAACTCT
GCCTTTTAGCTCCTCACTATTGTCTTCTTTCCTGTCACTTTTAGGCTGTTTCATTGGTCGTATAAAAACAACCTTCTTCGAAGTTGAATG

>41198_41198_3_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000265713_ASXL2_chr2_26068432_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

--------------------------------------------------------------
>41198_41198_4_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000396930_ASXL2_chr2_26068432_ENST00000435504_length(transcript)=15507nt_BP=2980nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGTGAG
CAGAGATTGCGGAGTACAGAATAGCCATCACCCACTCTGGCATAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGA
GTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTT
GGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTT
CCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTT
CACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGA
AGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAAC
AATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGG
AAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAA
AAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATT
GGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAA
AGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTG
TAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCC
ATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCG
AGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCG
TATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACG
GCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGG
CCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGG
CTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCC
TTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCAC
TTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGA
GAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCC
CTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCT
TTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCTGCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGA
GATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGGGAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTT
GTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATTTCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGT
TGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAATGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGG
CAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGAAGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCT
TTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCTTTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTT
GACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCACCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCG
GGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAATTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGT
CATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGAGGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATT
AGAGATCAGTGTCTTAGAAAAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAAT
CAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGG
TAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTC
AGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGTATC
GTCGTCCTCCCCGCAGTCAGGCTGCCCATCACCCACCATTCCAGCAGGTAAAGTCATTTCTCCATCACAGAAGCACAGCAAGAAGGCACT
AAAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCAGCAATGCAGGCCAAGCATATCCATCTCCTCCAACCAGCATCTCTCACT
AAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACCTGCAACATGGGAAGGAAAGCAATCTGATGGACAGACAGGCAGCCCTCA
AAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAATACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAGATCTGAGAGACT
CCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGACGTTGAGACACCGGACTCCATTCTGGTTAATACAAATCTGCGAGCACT
GATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCAGCAACGACTGCTTTTACTACTCCCAGAGGTAGATCGACAGGTTGGTCC
AGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGAATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAGACTCTCAGAAGG
TGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGATTGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACAATTCTTTGAAAG
CTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAAGAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAAGAAAACCCCAGC
TGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTATCAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAAAGAAGAAGCATT
GCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCAAGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGAGCCCCTGCTTTC
CTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCATCAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAAGCCAGTCACCTC
TGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTCTAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGTTACATCGCCAAG
CAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCCCACAGCAGGAGCGGGTCCACAGGAGACTAATATGAAAGAACCTCTAGC
AACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTCTTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGAGAAGAGGCCACG
TGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTCACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCAGGTGCGAAAAGT
ACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCCGTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTTTCCAGTCTCCAT
CACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACATCAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGCAGCAGCTGCCGC
TGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCATTCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGGAGAGGGTGGTGA
AGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGTCAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGCAGGAACTGGAAG
CAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGACTCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCAGGCACAGCCTCA
TAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCCTCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGTCCCATCACCAGC
CCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAGAGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACAAGGGCCCAGTAG
TTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCTAATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGATGGCACAGTTGA
GCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGCCTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGTAACTCCCTCCCC
TTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCCTGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGGATCAGCTCCACC
CTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGGAACTTCTTTAAACATGAATGGACCCACTTTAAGACCAACCTCTAGTAT
CCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAAAGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCTCACCAAAGTTGA
AATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGATGGGAGCGCTCATAGCTACCAACACAACAGAAAATAGCACCAGAGAGGA
AGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCTGGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGTTCCAAGGCCCCT
TCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGACACACACCAATACCACGAAGGACTAAGTAAAGCAACCCAAGATCAGAT
CCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCTCTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCACTCAGGTTTCCA
GCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTTTGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGGGCACTACTTACT
GAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAGGACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCTAAGCAGCCCCAC
TGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAACAGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGATGAGGAAAGTAC
TGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCAGGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTCAGGACCTCACAG
CAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAATGTGAAGGCTGAGATACCATTGAATGAGCAAACCACTTTAAGTAAGGA
GAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGACCCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCAGATGGCTCATGC
AGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAGTTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCACCCACCAGCCCCT
ACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCCCACCCAGATAGGGCCAAGCTATAGAGGCATGATCAATGTCTCCACCTC
ATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGTATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGTGACTGTCACTAC
CATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCAGACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAGCATAGAGGGCAC
GCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTGCAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCATCGGCCCCTCCAA
ACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAAAGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTTGACCAGTTGGGT
TTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTTTCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGGAATACAAAGTAC
AGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAGTCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAGTTTGCACTTACA
AAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTCCAAGTGTTTAGGTAATAATGTATTACTTTGAATTCAGATTAATGTTCT
ACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAAGGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCTAGGAAAAGGAAA
GTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTTGTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTATTCAGCCTTTGC
AGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGGTGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAATTCATTTCACAGG
TAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTTCTACTGTACTAGTTACTAGTTACTGGTACTGTTGCCAAGCAATCTGCT
TGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTGCCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGCCTCTCTGGGACC
CCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAAAAATACCCTATCCCCGCACTTAGTCATTCGTGGTAACTAACAATTTTG
AAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGGTGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGAAACCACAGAAAC
TGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACACTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCCCAACCTGTTAAC
CTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTCACCAATGCCACATTTGTTCATTCTGTTCAACCTGTTTTGACCTCCCAG
GCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTACACATACGTGTATGTACACACACACACACAATACAAGACATTTTTCCT
GTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGAGCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAATGGCTAAGGGAAC
ATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTTGCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTTTTTGTTTTTAAA
TCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTTAGGTCATGGTTAAGGAACATTAAAATAAACCTGCAGTTTAACAGAATT
TTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATATTGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTACAAATGTTAATG
CAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTGATATTTACAAAATGCAGAACAGTTTAAACTTGTTAAGTCACATTCCAG
ATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCATTCTACTACCCACCACTGCCCACCCCACCCCCACATCACACACTCTTC
GATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAAACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCTTTTTTGTGGCCC
AAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCAGAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCAGCACACACAGCT
AAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATATTTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATGGTGCTCCCAAAT
ATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCTGTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAACTCCACCTTAGT
GCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGAGTTTTGGAATTGATTCCATGCTAAATGTCAGTTACCAGTTTGGATTGA
TGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGGTTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACAGACTATAACTAG
GAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAGAGCAAACCATATTGTGCCTCTTCATCTTGACCCAGGCTCTTATAGATA
GGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAATACTCAGCTAAATATTTGCATTTAGGAATACTCCTAAAACAGATATTG
CCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAACAGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATACCAGTCTATTTAT
CAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCATCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAAAACACATTACAA
TCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTATTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATCTTTACCTTAGTT
TTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTAATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGCATTATTTCCAGT
GACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCACCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGTCACCCCAGGAGA
TAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCTAAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAATAATTTTGGAGA
ATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAATAGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCCCTATGCTCAAGA
TACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAATAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGAGCATACTTATTG
GGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCTCAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTTCCAGGTGAAGGT
GCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGTTGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCATAAATAACTCTCT
GGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGACTTCTCTGGTCATTACACTGCTATTTATTTCTAGAACTCACTATCAGTG
AGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACATCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTACAACTGTGTGCT
AAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTATAGAATAGTCCAAAGAGACTTTGAGAAACATGGTGATAGGCAGGGGCCT
TTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAACAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAGCTTCGTAGATTC
TTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAACTATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAATATATTTTAAGT
AATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACTTTGAATTTCTCATATATGGTATGTTTGATGTAGGACCTCACTGTTAAG
GCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGATTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTGGGGTTTATTTTT
TATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTTTTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTTGGTAAATGCTAA
ACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTGGAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACACCATTTAAAAAG
TCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAATTTTAAGTATTTGCAATAAATATATGTATATAGATTGTATGTATTCCT
ATATTCTTATTTTTCATTTTATTATTAAGTAAAAGATCATTAAAAGTGAAAATAAAAACCTTGGAGTTTTTTGGTGAATCTTGAGGTTTA
ACATACATCTGAGAGTGGCGTGGGTAAGAGTCCTCAGTTACTGCCTTATACTCCTATGGGATGGTTCCCACAGATTGTATGGAAGAGAGT
AAAATGAGGAACTTGGTGATAAATCAGGGTAGTGTATTTCTTTTGGAATTTAAGTAAAACTGATTAAATTTTCCTTATCTGTCTGTCTCC
ATGTTTTCTCCCTTAATCTGTTTTGTCTCCTAACCCCCTAACATTACTGGAAAAGTGAAGAAATGCGGTGCAGCCTCTTTATTAATGTGC
CCATTGTTTGCTCCTAAATCAAAGAATGGTAAGGAAATATCTCGGGGGAAAAAATAGGTTTTCCTTTCTCCACAGTGGTTGACATTTACT
GCCACCACTTTCCAGGCCTTAGGGGAGTGTGAAGAAATAGTTTCTTGAAGATGATAGAAATTTTTTTTTTTCCGTTTCCCAGTTCTCTCA
GAAGTGAGTTTCATAGCCAGTCATGTCCTTCCTGCCCGTCTAATCTGGAGAGGTCAAAGAGCAAGGAAAATAATGTGAAGAGAAACACCT
GTGCCTTGATTAGGTTCTATTTCAGCATTTGACACTTGAATTTTGAACTCCTCTGGGTCAGGAAGGGTAGCTATGGAAATGAGGTCTGAG
CCAGTTGGTAGGAGAGGTTGTCTATGTTCCCATACCGAGATTGCTGTCTAATCCACGAGAACTCATTTTGTGGCTGCAAAGTAAATACTT
GATTTTAGGATATGATAGGAGCAAAATGGTGCCTACATCGTCTTTATAAAGAAAAGTATATAGCCCATTTTTTAACAAATGAATAATATA
TCGAATCATTGATGACCTAAAAGAAAAATTGTTAAGGTCAGATTTTCGAGAGTGTATCTTGATGACCCATAAAACTGACTTTTTATTGTA
GTTCACTAGTTCCCATAATTGCCCAGCTGTGGTTACTTTCACTGAAAAGAAAAAATATATTTTGGAAGTTAATGTAAGGATACATTGGCT
TTTTTTTTTTTTCTTTACATTGGCTTTTTAAAAGACAGTTTTTATTTTTCAGATACTGGAATGTCAAGTATCTGGGTTGTCCCAAGACGT
TGGAGATAATTCAGCCTTCCAAGAGAACAGCAGTCTAGATCTTAGCTGAAAATGTGCTGTTTCTAAAGGAAGCTTCTTAAGTCTCAGGGG
ACATTAGCATCTTCATAATTTCCATATATAATAAGAATGAAGGTAAAATATTTAAATGTGTATAAACTAATCCATAATGACCATTTACAA
AGATTGACTCCCCATTTCTGGTACATATTTATCATTATTTAGATGGGTCTCCTATCTTGTGGGAAGATAAATTTATATTCAGGTGATGAC
ATGGGTGCCTGCAAGTAGAGTTGGTCTGCAGCTGAGGGAGAAGGCAACATACCAGAAGACAAGGCAGCTTCAACCTGGATCCCCAGCTAC
CCTTTATTTACTTCACTGAGTCAGAAACCCGTGTTCATTGCTTCTGAGACTACTTGACCTCAGCTGGTCTTTAGAAGTCTGGTAACTTTT
TATGTACAAATCATGTTATTTACTAATTCAAGTATTTATAGAGCACCTACTGTGCACTAAGCACTAAAGTGCTGGTTATGCAAAGGTAAG
CAAAAATAGTCATGTAAGTTGCAGAAAGGTTTTCCTAAAGTAGTGACTATACAGCATGTTTTTAGTTCTAGGCTCAAGGAGTAATACTAC
CTTTTTCCCAAGATAGGTTGAAAATTTAAATGAGTTATGAAATGGAAGTGTTTGAGACACTGGACACAGTAGTGGCAAATACATGAAGAA
AGAAGGTCCCTAGATGAAAAAAGTGTGGAAATGAGGAGCCATATTAATAAAATGCACCTTTTTTGAGAACTATTGTTGGAATAGCTAAAG
TTGTCTATAGAAATTTCAAGAAATCTCTTAACATCTAAATTAGAAGCAGGCCAACAGCAATCTCTGTCAGTAGTTAATTTAGGTCAGTAA
GTTAGTGTTTTGTTAAACTAACCCTTTCAAACACAGTTGGGTAAATAATGCAGCTTTCCTGTCACTGTTCAAACCTAAAAGAAGCTAAAG
GGAATTTTTCTTAAAACATGATTTTCATCTTATAGATGATAAGTAACTGTATCTCTTCATTTGGAATTGTTGCATCCCAGTTTTTCTCCA
TAATGGATAAAATTACTTTTGTGTCCTTTTCTATTCTAATGTAGAAGTGGCTTTTCCTTTTTTCTCTTGAGTCACAACTTGAATTAAAAA
GGGCTTCAGCAGGACTCTAGCGCTTTTTAAAGAAGAATTTGGTGTATTCCACTATGTAACGTAGTCTCTGTCCAGGAACCAGGAGGATGA
GTGTCCTCAGTTTTCCTAATACTTGGTAACATTTAATAATAGATTGAGTTTTGCTTTTGTTTTTCATAGAGACTGTATAGACTCTGTACT
TCCATGTAACTTTCTGCCTTAACCTAAAAAGGCATTCCCTGGAAGGAGATCTTGTAACAGGAAGAAAAAGCGAAACCAGGAAAAGAGCCA
GAAAGGATCAACTTGGAGATGGGCTGTGGCTAAATAGTGGGTTTTCCTGAAAAGTAACTGCAACCTTGCTTTTCGTGCTTCTTCAAACCC
AAAAGAACCTAAAGGGAATTTTTAAAAATCCTGATTTTCTTCTTAATTGTAAAACCTAGAGGATGCCTTAGGGAGAAGAAAGATAACCTG
GAATTTGGTTTTAAATGGATTTAAGTAAACTTTGAATTAAGTAGCTTATTCCATTTTTGAGAGATTTCTTTTTAAGATTTTAGATTCACT
TAATGTAATGTTGAATTGCCATGAATGTAACCTGGAGTTTGATTTGAGACATTCTGTGGGATAAGGAATAGTTTTCTATTGAACTGTGGT
GGCTTTTGCCACTAATCAGGATTTAGGGCTGTGCACCTCCATCTGTTAAGTGAAATGGAACTTGGCTTCCTAAACACTATATTAGACCAA
CTTGAGTCAATACTTTTATTAAGTTTAATCAGGGATTCTCAAAATATTTAGGATTCAAATTAGCCCAATTAGAAAGCAGTGCATTAAATG
TTACCAAAATATCTGAAGATACTTTAGAACTATTTTACACAAAGCTTATGTCTTTCCTATGGAAAGTATCATACATAAAATTTTACATTC
TTTTAAAAAACAGAATCTAATGTCTTCAGATACCTAGAGCTTGGAAATTATAATAGAGTTGGGCTTTGACCCGAAGTCAGCAGTTCTTTT
CATTTTAGATTTTCAGGCAAGTTTCAGTAGTTTGGAGACTTCTTCAGTAGTGACCCCAGCTTAACCTACATATAATCACTTTGCACACAT
TTTAAGTTAATCAGATGCTTCCAGAGTCTTGGATTTGGTTACCCCTTTGTTAGATAAGGAGACAGATTCTAGGTTGGGACAAACATCTTA
ATTTATTCTCTAATAATAAAGTACTGATTAAAGAGCAAGTTCTCAGAGAATTCACAAAATTTCTAGAATCCATGAAAGATCTAGAGAACA
TAACAAATGAAACTCTAGAAATTTGAAAGAAAAAAAAACACTTAGCTGTAAGTGCTTTGACCTATTTTTTTTAAAAAAAAAAAACCTGTC
TTAATTCTGTGACTGCATTGCACCCTTCACCAGCACTAAGAGAAGTCGGAATGGAAGAAATTACCGTATGTAATTCTTATTCACTTAAAA
TCTTTGTGCGCATAGGCCTTAGCACTTTGACAAATAAACTCTGCCTTTTAGCTCCTCACTATTGTCTTCTTTCCTGTCACTTTTAGGCTG
TTTCATTGGTCGTATAAAAACAACCTTCTTCGAAGTTGAATGTATGTTTCTGCACATAGACAAACCATATTTTACTGACTCATTCTATGT

>41198_41198_4_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000396930_ASXL2_chr2_26068432_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KAT6A-ASXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417144_664812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518144_664812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518144_664812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417312_664812.02005.0RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518312_664812.02005.0RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518312_664812.02005.0RUNX1-1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171517_1642812.02005.0RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181517_1642812.02005.0RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181517_1642812.02005.0RUNX1-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KAT6A-ASXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KAT6A-ASXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource