Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KAT6A-EP300 (FusionGDB2 ID:41203)

Fusion Gene Summary for KAT6A-EP300

Fusion gene summary

Fusion gene information	Fusion gene name: KAT6A-EP300
	Fusion gene ID: 41203
		Hgene	Tgene
	Gene symbol	KAT6A	EP300
	Gene ID	7994	2033
	Gene name	lysine acetyltransferase 6A	E1A binding protein p300
	Synonyms	ARTHS\|MOZ\|MRD32\|MYST-3\|MYST3\|RUNXBP2\|ZC2HC6A\|ZNF220	KAT3B\|MKHK2\|RSTS2\|p300
	Cytomap	8p11.21	22q13.2
	Type of gene	protein-coding	protein-coding
	Description	histone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription	histone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein 2-hydroxyisobutyryltransferase p300protein propionyltransferase p300
	Modification date	20200313	20200329
	UniProtAcc	Q92794	Q09472
	Ensembl transtripts involved in fusion gene	ENST00000406337, ENST00000265713, ENST00000396930, ENST00000485568,	ENST00000263253,
Fusion gene scores	* DoF score	26 X 32 X 13=10816	22 X 26 X 8=4576
	# samples	42	25
	** MAII score	log2(42/10816*10)=-4.68663391861606 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(25/4576*10)=-4.1940870521163 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KAT6A [Title/Abstract] AND EP300 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.	KAT6A-EP300 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT6A-EP300 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KAT6A	GO:0006473	protein acetylation	23431171
Hgene	KAT6A	GO:0016573	histone acetylation	11742995\|17925393
Hgene	KAT6A	GO:0030099	myeloid cell differentiation	11742995
Hgene	KAT6A	GO:0043966	histone H3 acetylation	16387653
Hgene	KAT6A	GO:0045892	negative regulation of transcription, DNA-templated	11742995
Hgene	KAT6A	GO:0045893	positive regulation of transcription, DNA-templated	11742995\|11965546\|18794358
Tgene	EP300	GO:0000122	negative regulation of transcription by RNA polymerase II	10733570
Tgene	EP300	GO:0001666	response to hypoxia	9887100\|15261140
Tgene	EP300	GO:0006110	regulation of glycolytic process	29775581
Tgene	EP300	GO:0006355	regulation of transcription, DNA-templated	15261140
Tgene	EP300	GO:0006473	protein acetylation	21030595\|24939902
Tgene	EP300	GO:0006475	internal protein amino acid acetylation	18722353
Tgene	EP300	GO:0010742	macrophage derived foam cell differentiation	26504087
Tgene	EP300	GO:0010976	positive regulation of neuron projection development	27256286
Tgene	EP300	GO:0016573	histone acetylation	25818647\|27256286
Tgene	EP300	GO:0018076	N-terminal peptidyl-lysine acetylation	12435739
Tgene	EP300	GO:0018393	internal peptidyl-lysine acetylation	17403783
Tgene	EP300	GO:0018394	peptidyl-lysine acetylation	23811396\|23962722
Tgene	EP300	GO:0031333	negative regulation of protein complex assembly	23962722
Tgene	EP300	GO:0034644	cellular response to UV	24939902
Tgene	EP300	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17403783
Tgene	EP300	GO:0043627	response to estrogen	11581164
Tgene	EP300	GO:0043923	positive regulation by host of viral transcription	16687403
Tgene	EP300	GO:0043969	histone H2B acetylation	23415232
Tgene	EP300	GO:0045721	negative regulation of gluconeogenesis	30193097
Tgene	EP300	GO:0045815	positive regulation of gene expression, epigenetic	25818647
Tgene	EP300	GO:0045944	positive regulation of transcription by RNA polymerase II	12586840\|18722353\|23811396
Tgene	EP300	GO:0051091	positive regulation of DNA-binding transcription factor activity	10518217\|25818647
Tgene	EP300	GO:0060765	regulation of androgen receptor signaling pathway	18487222
Tgene	EP300	GO:0061921	peptidyl-lysine propionylation	17267393
Tgene	EP300	GO:0090043	regulation of tubulin deacetylation	18722353
Tgene	EP300	GO:0140066	peptidyl-lysine crotonylation	25818647
Tgene	EP300	GO:0140067	peptidyl-lysine butyrylation	17267393\|29775581
Tgene	EP300	GO:1901224	positive regulation of NIK/NF-kappaB signaling	23811396
Tgene	EP300	GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	23811396

Fusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EP300 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB4	.	.	KAT6A	chr15	41798359		EP300	chr3	41521867

Top

Fusion Gene ORF analysis for KAT6A-EP300

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000406337	ENST00000263253	KAT6A	chr15	41798359		EP300	chr3	41521867
In-frame	ENST00000265713	ENST00000263253	KAT6A	chr15	41798359		EP300	chr3	41521867
In-frame	ENST00000396930	ENST00000263253	KAT6A	chr15	41798359		EP300	chr3	41521867
intron-3CDS	ENST00000485568	ENST00000263253	KAT6A	chr15	41798359		EP300	chr3	41521867

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000265713

KAT6A

chr15

41798359

ENST00000263253

EP300

chr3

41521867

11088

3451

4579

4064

171

ENST00000396930

KAT6A

chr15

41798359

ENST00000263253

EP300

chr3

41521867

11220

3583

4711

4196

171

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for KAT6A-EP300

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KAT6A-EP300

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:/chr3:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KAT6A Q92794	EP300 Q09472
FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269\|PubMed:11742995, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:12771199, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:17925393, ECO:0000269\|PubMed:23431171}.	FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250\|UniProtKB:B2RWS6, ECO:0000269\|PubMed:10733570, ECO:0000269\|PubMed:11430825, ECO:0000269\|PubMed:11511361, ECO:0000269\|PubMed:11701890, ECO:0000269\|PubMed:12402037, ECO:0000269\|PubMed:12586840, ECO:0000269\|PubMed:12929931, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:15186775, ECO:0000269\|PubMed:15448695, ECO:0000269\|PubMed:15890677, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:16762839, ECO:0000269\|PubMed:17267393, ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:18451878, ECO:0000269\|PubMed:18722353, ECO:0000269\|PubMed:18995842, ECO:0000269\|PubMed:20810990, ECO:0000269\|PubMed:21030595, ECO:0000269\|PubMed:23415232, ECO:0000269\|PubMed:23911289, ECO:0000269\|PubMed:23934153, ECO:0000269\|PubMed:24939902, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:25818647, ECO:0000269\|PubMed:29775581, ECO:0000269\|PubMed:30193097, ECO:0000269\|PubMed:31645732, ECO:0000269\|PubMed:8945521, ECO:0000305\|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269\|PubMed:10545121, ECO:0000269\|PubMed:11080476}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

339_353

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

786_803

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

804_832

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

842_862

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

873_888

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

889_926

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

930_946

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

952_987

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

339_353

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

786_803

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

804_832

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

842_862

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

873_888

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

889_926

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

930_946

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

952_987

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

339_353

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

786_803

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

804_832

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

842_862

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

873_888

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

889_926

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

930_946

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

952_987

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

504_778

1013

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

95_171

1013

2005.0

Domain

H15

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

504_778

1013

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

95_171

1013

2005.0

Domain

H15

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

504_778

1013

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

95_171

1013

2005.0

Domain

H15

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1_144

1013

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

334_375

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

441_464

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

488_778

1013

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

52_166

1013

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

645_649

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

654_660

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1_144

1013

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

334_375

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

441_464

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

488_778

1013

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

52_166

1013

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

645_649

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

654_660

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1_144

1013

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

334_375

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

441_464

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

488_778

1013

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

52_166

1013

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

645_649

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

654_660

1013

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

206_265

1013

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

259_313

1013

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

537_562

1013

2005.0

Zinc finger

C2HC MYST-type

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

206_265

1013

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

259_313

1013

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

537_562

1013

2005.0

Zinc finger

C2HC MYST-type

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

206_265

1013

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

259_313

1013

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

537_562

1013

2005.0

Zinc finger

C2HC MYST-type

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1520_1547

243

2415.0

Compositional bias

Basic and acidic residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1548_1565

243

2415.0

Compositional bias

Basic residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1851_1886

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1909_1924

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1989_2010

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2100_2114

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2115_2163

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2206_2237

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2267_2310

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2311_2342

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2362_2385

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

753_811

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

827_849

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

857_895

243

2415.0

Compositional bias

Pro residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

896_926

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

941_971

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

974_1029

243

2415.0

Compositional bias

Basic and acidic residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1067_1139

243

2415.0

Domain

Bromo

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1287_1663

243

2415.0

Domain

CBP/p300-type HAT

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

566_645

243

2415.0

Domain

KIX

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1017_1029

243

2415.0

Region

Note=CRD1%3B mediates transcriptional repression

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1398_1400

243

2415.0

Region

Acetyl-CoA binding

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1410_1411

243

2415.0

Region

Acetyl-CoA binding

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1520_1578

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1572_1818

243

2415.0

Region

Note=Binding region for E1A adenovirus

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1833_1924

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1980_2010

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2094_2163

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2186_2237

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

2267_2385

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

482_518

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

729_1050

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1665_1713

243

2415.0

Zinc finger

ZZ-type

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1728_1809

243

2415.0

Zinc finger

TAZ-type 2

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

331_417

243

2415.0

Zinc finger

TAZ-type 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1011_1029

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1124_1148

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1149_1171

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1201_1226

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1227_1245

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1271_1286

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1287_1320

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1321_1347

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1355_1369

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1390_1420

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1423_1437

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1478_1621

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1646_1701

1013

2005.0

Compositional bias

Pro residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1011_1029

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1124_1148

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1149_1171

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1201_1226

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1227_1245

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1271_1286

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1287_1320

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1321_1347

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1355_1369

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1390_1420

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1423_1437

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1478_1621

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1646_1701

1013

2005.0

Compositional bias

Pro residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1011_1029

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1124_1148

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1149_1171

1013

2005.0

Compositional bias

Basic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1201_1226

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1227_1245

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1271_1286

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1287_1320

1013

2005.0

Compositional bias

Acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1321_1347

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1355_1369

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1390_1420

1013

2005.0

Compositional bias

Basic and acidic residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1423_1437

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1478_1621

1013

2005.0

Compositional bias

Polar residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1646_1701

1013

2005.0

Compositional bias

Pro residues

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1461_1621

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1637_1721

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

1913_1948

1013

2005.0

Region

Note=Required for activation of RUNX1-2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000265713

785_1445

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1461_1621

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1637_1721

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

1913_1948

1013

2005.0

Region

Note=Required for activation of RUNX1-2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000396930

785_1445

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1461_1621

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1637_1721

1013

2005.0

Region

Disordered

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

1913_1948

1013

2005.0

Region

Note=Required for activation of RUNX1-2

Hgene

KAT6A

chr15:41798359

chr3:41521867

ENST00000406337

785_1445

1013

2005.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

196_234

243

2415.0

Compositional bias

Polar residues

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

11_17

243

2415.0

Motif

Nuclear localization signal

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

133_157

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

196_235

243

2415.0

Region

Disordered

Tgene

EP300

chr15:41798359

chr3:41521867

ENST00000263253

1_29

243

2415.0

Region

Disordered

Top

Fusion Gene Sequence for KAT6A-EP300

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41203_41203_1_KAT6A-EP300_KAT6A_chr15_41798359_ENST00000265713_EP300_chr3_41521867_ENST00000263253_length(transcript)=11088nt_BP=3451nt
CCAGGCTGCAATGCAGTGGCATGAACATGGCTCACTGCAGCCTGGACCTTGCAGGCTGAAGGAATCCTTCCACCTCAGCCTCCCAAGCAG
ACGTGGTGGCTCATGCCTATAATTCCAGCACTTTGGGAGGCCAATGCGGACAAATCACCTGAGGTCAGGAGGTCGAGACCAACCTGGCCA
ACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAGTTAGCCAGGTGTGGTGGTGGGCACCTATAATCCCAGCTACAGAGGCTGAGGCA
GGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATTACACCATTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCA
TCTCAAAAATAAATAAATAAATAATAAAAAGACTGACAATAACAAGTGTTGGCTAGGATTTGTAGCAACTAAAACTCTCATACATTGCTG
CTGGGAGTATAAACTGCTACAATTCGGCCTAGGCAACATAGTGAGACCCCATCTCTACAAAAAAATTTAAAAATTAGCCAGGAGTGGTGG
TGTGCACCTGTGATCCCAGCTACTTGGGAGGCTGAAGTCGAAGGATCTCTTGAGCCTAGGAGATTCAGGCTGCAGTGAGGTAGGATTGCA
CTGCTTTACTTCATCCTAGACAACAGAGTGAAAGCCCATCTCTATTAAAAAATCGTACAATTGGTCAGACGCAGTGACTCACACCTGTAA
TCCCAGCACTTTGGGAGGGTGAGGCGGGTGGATCACCAGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGCAAAACCTTGTCTCTA
CTAAAAAATACAAAAATTAGCCAGGCGTGATGGCAGGCGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGCACCC
GGGGGAAAGAGTTTGCAGTGAGCCAAGATCACGCCACTTTATTCCAGCCTGGATGAAAAGCAAAACTCCATCAAAAAAAAAAAAAAAGAA
AAGGGTACAACCCTTTGGATAATACTGGGATTAGAGTCGTGAGTCACTGTGCCCAGCGGAATATTTCAAACATACATGCAAGTAGAGAGA
ACAGTATAATGAGTGAATCCCCAGTGTACCTGGCATCCTGCCCCAGCTATTCAGGAGGTTGAGGCAGGAGAATCGCTTGAGCTCAGCAAG
CAGAGGGAAGCAGAGGTTGCAGTGAGCTGAGGTTGCACCACTGCACTCCAGCCTGGGCAACAGAGCAGCCTGGGCGACAGAGCGAGACTC
TGTCACAAAAAAAAAGGAAACCTACTGAAACAGGCCAGGTGCAGTAGCTCATGCCTGTAGCCTCCTCTGTGCATAGATCTCGGGCACGGC
CCTTCAACGGGCGGCGAAAGCTGCGACTCGATGATTCCTCATTGTAGAGTTGGGTGGTCCAGGAGGCTTAACTGGAGCCCTTGACCTGAG
CGGTAAGGGCAGTCAAAATGGCAGAGCCTGGATTTGAACACAGGCAGTCCATTTTCATACTGTTTACCTCCCATCCAGGAAAAGGCACAT
CTGTATACTTCGCTGTTGTCATGCTACAAATAGTAATTAATACAAGTTCTATGCCAAATTTAAGATGAAATTTTGTAGACAGGTCTTTGC
TCACTTCATCCACTTCCTTCAGTTCTCTACTTATCTAAGTTTTCTCTTTCAATATTGACCTCTATTTTTAACCTTTAGGGATTTTTCCCA
CCTCTGAAATCGTGTAGCACTGATCTTCTATGCAATTAATTTCATCACTGGGATGTACTGCCTTGCAGCCAGCTTGCAGATATCTTTGGC
CAGCCCAGCGTTTTTTGTTTTATAATTGATTTATAGTTTATATACCACAGAAGTCATCATTTTATTTTATTATTATTATTTTTTTGAGAC
GGAGCTGCTGCCCGCCTGGCACGGCTCATGTGTGTGTTCCTGGTGGACAGTGAGCTGTTCCGGGAGTCCCCAGTACAGCATCTGGTGGCA
GCCCTCCTCGCCCAGCTCTGTCAGCCTCAAAGGCATGAACCACCGCACCCGGCAAATGATCATTTAAGCAAATGATCGAAGACTCAAGAC
ACAAAACTACCTGAAGGGAGTGGCTCCCACATTTGTAGGGTACCTTACAGAGCAATTTCCCTTCATATGATTTTGCAGGTGGGGTGACGG
GTGTGGCCGCGACCGCAAGGGCAGCTGTTGCGGGGTTCTCTCTTTCTTTCATATCCTATTTCCACCCGCCTTAACGTCCTGCGCCTTCTC
CCAACACCTTTCAGGCGCCATTCTCTGCTCTAGCCCGGGGTCCCAGGAGACTTTTCTGCGGTCCGGCTCCCGGGCCCCGCCGATTCCCTC
CCCCGCTGCCCGCAGGGTAGCCCGGAGAGCCAGCTCGTCTGCCTCGGGGAGTCTCGAGCCGTTGAAGACCAGCTGATTACCCCCTCCTCA
CCTCCTTCACTCCCACTTGTGAACAGACAGCATTTGCATCATGATGCTGGAGAAGAGAGGGCCACACTGGGATTTCCACCGGGAGATTCC
AGCTTCTCCCCCATCCCCCATTTTTGTAGTCAAACTCTCCATCACTCTCCACTTCCAGGGGGCGACGCTTCAGAGACTGACAACCTCTGG
GCTGATGGGGAAGATGGAGTATCCTTCATACAATGATTATAGGCGTGTGCCACTGTACCCAGCCAAAGGCATGTATTTACTATATCCCAG
CCCTACCACACCATATCATATCAGTTCTTTTACTCACAGTCACCGAGAACCACGGAGAGGTAGAGATCCGAAGGCACCTCAACTGCAGTC
ACTGCCCTTTGAGAGACTGCCAATGGCAGGCAGAGCTCCAGCTGGCTGAATGCCTGTGTACAAAATTAGCTGGGCATGGTGGCGCATGCC
TGTAATCCCAGCTACGTGGGAGGCTGAGGCAGAAGAATCACTTGAACCTGGGAGGCGGAGGTTGTGGTGAGCCGAGATTGCGCCATTGCA
CTCCAGCCAGGGCGACAGAGTGAGACTCTGTCTCAATAAAAAAAAAATATGATCTGGCGCCTGTAATCTCAGCACTTTGGGAGGCCAAGG
CAGGTGGATCACCTGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTGTCTACTAAAAACACAAAAAATAGCTGGG
CGTTGTGGCGCTTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCACTTGAACCCGAGAGGCAGAGGTTGCAGTGAGCCG
AGATCGCGCTATTGCACTCCAGCCTGCATGACAGAGTGAGACTTCGTTTAAAAAAGAAAAAAAATCATGACTCTTGGAGCCCAGGGATTG
CCTCCCGCCCAGGGCGTCTGCAGGGACCAGGGAAGTCCTCATCATGCACTCCCACCTTGACTCTGGCCCGCATCTGCCCTCTTTTTTGCC
CTGGCTCTATGCCAGTGAGCACCACCCTTGCTTTCCACTGAAGAATACAGTTGACCCCTGAACAACATGGGTTTGAACTATATCCACTTG
AATGCAATTTTCTTCTGCCTCTGCCACTCCTGAGATAGCAAAACCAACCTCTCCTCTTCCCTGTCCTCCTCAGTCTACTCAATGTGAAAA
TAAAAATGAAGACCTTTACGGTGATCCAACCTAGGGTGGGTGCGTTCCTCCTCTTACTTTTGGGAATGTCCTACTTCGCCTATGAAGTAG
CTATTCTTTCACCACTTTACTTAATATATTTGCTTTCACTTTGCACTGTGGAATCACCCTGAATTCTTTTTTGCATGAGATCCAAGAACC
CTCTTTTGGGGGCTGGATCAGGACCCCTTTCTGGTAACACAGGTACCACCTAGTTACTGTGCAGCAGCCAGTCTGCACGAGGGCACTGGC
TCCCAGGCCACAGCCAGCTGATACATCCTGGTCTCAGCACTACCACACCTGAGTGACTTTTTTTTCTTTCTTTTCCTTTTTTTGTTTTGA
GATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCACCATAAAGGAAAATAAATAAGGAAACCTGGTTAAATGCAAAATAAC
ATAATATTCATTCTTTACCTCCTTGCACTTGATCTCCGGATGGCTCTAAACATATCTGACCTTTTGGAAACTGCCGTTCCTTGGTTTGCT
GGACACCTCACTCTTCTGGGTTTCCTCCCTGAACATTCCTTTCCAGTTTCCTGGAGCTTTTTTCCCTTTACCCCACAATCAAGCATGTGC
ACGTATCTCATGAATATCAGTCCTCCACACTCCAGCTCCAGCACAGACCCACACTTCCAGCCAGAATGTATGTTCATAGCTGACTGTGGT
CTCATCATTCGCTCCTGCCTCTGTATTGTGAATACTGCCGCAATAAACATACGTGTGCATGTGTCTTTATAGCAGCATGATTTATAGTCC
TTTGGGTATATACCCAGCAATGGGATGGCTGGGACAAATGGTATCTCTAGTTCTAGATCCCTGAGGAATCGCGACGACATGATTGTGTAT
CTAGAAAACCCCACTGTCTCAGCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAA
TCACAAGCATGGACAAAATTGACAAATGGGATCTAATTGAACTAAAGAGCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGAACAGGC
AACCTACAAAATGGGAGAAAATTTTTGCAACCTACTCATCTGACAAAGGGCTAATATCCAGAATCTACAATGAACTCAAACAAATGTACA
AGAAACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGATCAAGACCATCTTGGCTAACACGGTGAAACCCCGTCTCGCCAGCA
CTTATCTTTTATCTTTTAAATAACAGAGATGGGCAGTTTCTTGTAAAGTTTAAAAGCACATTTACCATATAACCCAGCAATCTCACCTCT
AGGTATTTGCTCAGAAGACATAGATTTCCATCTGCAGATGCCAGCTGTCAGCTCTAGCTCTGCATGGTACCCAACCTTCTTCCAGAACTC
TGAAAAACTAAATAATGATGTCTTTTTATATCTTTTCAGATTATATTTAATTTAAAAGTAGACCACACAGGTTATTTACTGTCTCCCTCA
CCTAAAACATAAGATAGGGGCCTTTGTTTGTTTTATACATTGTTGTGACCAGACCCTAGAATAGCAGCTGAAATTAGTTCTCAAAAAATA
TTTAAATAAATGAATATGTGAATGACTAAGCAAATGGAAATAAAAGCCATTTCTGTTATGACTCAGGCTTGCAGATTGACATATGCAAAT
ATGGAAGTGTAGAGCATAATTTTGAATTTCATTTTCCATCAATGTCTGATTACCTACTGATTAAATGTGACAAGCTACAAAGGGAGAAAA
ATCATTATTAAATTCCAATCTATCATCTATAACCTAAATGCAACTAATCATATGTTTAATTTTATATAATAGCTTTCAGACAGAAAAAAA
TCTACAGGCACAATGTCGTAAAAAATCTCCAGTGAATTTTGTACTATATCAAGTGGTCTAACCTAGCTGAAAAGATGGTTAGGCAGATTT
CCTAAGTGTGGAAATATAGGAATCTACACTGGAGGAAGAATAGCAGAAGTTGACAATAATTCATCTAACATTCTTTTCCAGGTTTTGAGC
CACACAGTAGAAGCTGTGTAGAAATCCTGGATTGTAGTCATTTTCTTTCTATTTTAGACCACAGTTCTCCAAAGCAATACACTGGAGTGT
GATTTAAAATATATATATATATATATATATATATATATATATATATATGAACATGTTTTACAATTATTTTTACCAAAAAGATAATAACTG
AAACTGGTCTTTTCCTTGGCACACAGTCTTCAGGTTATCTAAAGTCAGGACAAAGAAAAGGATCTTAAGAGCTGTGAGGTAAAAGCATCA
GGTAACCCATGAAAGAAAAACTATTACAGTAACAACAGATTTAACAGATTCACAACTGAATTATATCAGACATTCAGAGAAGAACTGGTA
CCAACCCTAGTGACACTATTCCATAGAATAAAGAGGAAATCTCCCCTAAATCATTCTATAAAGCCAGTATCACCCTAATACCAAAACTAG
GAAAGGACATAACAAAAAAAGAAAACTACACACCAATATCCCTGATGAACACAGATAAAAAAATCCTCAACAAAATAACCAATCCAACAG
TGTATCAAAAAGAAGGCACATAGACCAATAAAATATAATAGAGAAACCAGAAATAAAGCCAAATACTTACTGTTAGTAACTTACTAATCA
GCTAACTGATTTGCTAAGGCAGAAGAATGGCTTGAACTCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGTCTG
GGCTGTGCAGCAATGGTGCTATGATTTGAATCTATCCATCCCTCCTCCAGCACAATTCATCCCAGTAATAACTGTCCTCACTTTAAATGT
CCTACCGTTTGCTGAATATGGCAGTAATGTGCTTCAATAATGCTGCCCCACATGAAAGAAAAACACCCACTGACCAGGAGTGCCACACAT
TCTACTGTTACACTACTGAAAAACCAAGTACAGTGGCACGATCTCTGCTCACTGTAACCTCCACCTCCCAGGTTCAAGCGATTCTGCCTC
AGCCTCTTGAGTAGCTGAGACTACAGGCATTCACCACCACGCCCGACTAATTTTTGCATTTTTAGTAGAGATGGAGTTTCATCATGTTGG
CCCTAAAAGAATCCAGCACATAATGTCTTACACATATTAGGTTCTCAATAAAGATACATGGAGAGAAGGAAGACATGAAGCACGTCACTA
CTAATAAGATCAGAAGTGGGACAACACATATGTTACAGGGCATTCTGGGACTGAAGCTAGCCAAAAAACCCCATGCTGCATGATTCTTTT
TCTATGATATGTCCAGAATATGCAAATCTATAACGACAAAGTAGCTTAGTGGTTGTCTAGGCAGAGGTGATTTAGGGGAGAGCAAGACTC
TGTCTCCAAAAAGAACAAACAAAAAACAAACAAACAAACAAAACAAAGGAAGAGGAGCTAAGTCTGAGATAAAGACGGTTAACCAAACTA
GGTGAAAGATGAGACTTGAGAGCATTCTGGAAGCTATAACAGGGTCCAAATAAATATTTCAGTTGCTATTATTTGTTAGAGTCCATTACA
TAAAGTGCTTTACATACATTATCTCATTTAACTCTTATGAACTTTGTAAAGAAGACTTAAGCTCTATTTTTATCGACAAGGAAACCAACT
TCACAGCCCTCCTGTAAGGACAGAAGAGGGTAACATGTGTACAGCTTTGAAATAGTATACTCCCTCATCGAGCAGGACACAGAAATAACC
AGATAAGGCAGGAGACTGGCCATCACCTCTAGGTAGACTCACCCTGAAGAAGCACAAAGTGACAGACAATTCAAGCTGGAAATCACTTTT
TACTCCTACACTGAAATATTCTCCCAATTCCATTTTTATTTATTTATATTTTTGGAGACGGAGTCTCGCTCTGTTGCCAGGCTGGAGTGC
AGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGTGATTCGCCTGCCTCAGCCTCCCGAGGAGCTGGGACTACAGGT
GCACGCCACCAAGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGGCCAAGATGGTCTCGATCTCTTGACCTCG
TGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAAAAATTAGCCAGGTATGGTGGTGGGCGCCAGTAGTCCCAGCTACC
CGGGAAGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCGAGATCACTCCACTGTACTCCAGCCTAGGTGAC
AGAGCAAGACTCCGTCTCAAAAAGAGGGGAGGGGAGGGGAGGGGAGGGGAGAGGAGGGGAGAGGAGAGGAGAGAAGAAGAAAAAGAAAAG
AAAAAGAAAAAGAAAAAAAAAAGAAATAAACATCCTTCTCATCAACAGTTAGCTGCAAAAAAAAATATTTCTAGCATCTTAAATGTAAGA
TATTACAAAAGACCAAGTGTGGTATTACTATAATTTAAACTTTACTTGCATATAATACTGTAAGGTGTTTTATTCCTCCTATAGGTAAAC
CAAAACAACAAATATTGTTTAAGTAGTTTCAAAGAGGAAAACCAGAGTCAAATAGAGTAGAAATTACAGAGAAGAAATTTCAGTTCAGTA
GAAAGAAACACTTTGTAACAATTAGAATTTTTCAAAGGTGGAGTATGCTGCCTTGTAGGAAAAAGGATTTTCTAACCCCAGATAGATTCT
CACAGTAATCTCTCAAGATGATAGAATACAAGAGATTCCAGTCTAATGGGAGCTGAGTCTAGTACAATGGTTTTCTAACCTAGATTATGA
TTATAGCTTCACCTGGGAAGCTTCTAGGCACTCCCCTGAATCTGCTTCCCAAACCACCGGTCTAATCTATACAAGTTAGCCAACCAAGAC
AGACAGGTAGACAGTCACAAGTTCCCAAATGATTTTAATGCTTTCAAATAGGTTTTGACAAAAATGCACCTGTGTACTCCGACCGCATCA
ACAAGCTCTGCTGATTTTTCTTACTGCTCTTCCCAGCATTTAATCTACTGCAACCACACATTCTACAGGCTATTCCACTGATATGCCAGG
TGTGCGCCCACTCTGAGCTTTTGCACTTGCTGTTCTCTTCCCCTGGGTATCTGCATGGCTTGCTGCTTCACTGTCTCAAGCTTTTATTTA
ACAATCACCTTCACCATGAGGCTACCCAGTGAAGGACTTCAACCTCTACTCCCATCCAGATACGTCATATCCCCTTTCTTCATTTTATTT
ATTCTCAGTATTTATTAACTAACATCTAGCATCATCTAACAAACTTATCATCTTAATTTTGTTTGTTTTTTATTTTTTCCACAAAAATGT
AAGCTCCATGAAGGCAGGGATTTTGGTCAGTTTTATTCATTGCTGTATTCTTTGCACATGGAACAATACCTACAAATATCTGTTCAATGA
CTTAATGAACTAGATCTGGGGTGGCAAACTCTAGATCTGGGATAAAGTTTTACTGGAACACAGTCACACATTCATTTATATATTGTCTAC
AGCTGTTTTTGTGCTACAAGAGTGGATTTAAATAGTTGTACCAGAGACTGTATGGCCCATAAAGCTTAAAATATTTCTTGTCGAGACTTT
TACAGAATAAAATTTGCCAATCCCTGAACTAGATGCACCAATCAGAATGTCATGTAGAGTTCCGATTCCAAACTTCTAGGTAACTGTGGT
AGATTAAAGATGGCCACAAATTACTGTCATTAAGAGCTAGAGTCTCTTTCTCCACCCCTTGAACCAATATGGCTTAGTGATTCTCTCAAC
CAATAAAATGTGATGAAATTAACATGAGATTTCCAAGCCTAGGCAGCAAGAGGCCTTGCAGCTTCCACTCAGGCCGTCTTCAAATACTGC
CACCATGTTTAAAAACCTGAGCTAGCCTCCTTGAGTATAAGAGATCATGTAGAGAGAGAGGTCCACCCTCCCCATACTGAGGCTCCCAGT
ATGTGAGCAAGCCCAGCTGACACTGTGGAGCCCAGATCATGCTGCCAAAGCACACAACACACCACGGAGCCCAGACCATGCTGCCAAAGC
ACACAACAGTGAGCAAATATGTGTTATTTTAAGTCGCTTAGCTTTGGATGGTTTATTATGTAGGAGAAGTTATTTGACATAGTAAAATTT
ATTTATTATTTTTAGACTAAATCCTTAGATTTTCCCTTTTTCCTTCATACATCTCCATACTACTGTGGGAGCAGCAGCCTCAATCTCAAA
TTATTTACTCACATGTAATGTCCCTGTTACTTCAGTTAAATCACAATTTAATAACTAAATTTTATAAATATGTTGACGCGTGAAGATTTG
AGAGTAGTTTGGGAAGCGTTTGAATTAGTTATTGGACAGAGGTTGGCAAGCCATGGCCTGTGGGCTACCCACCTAATTCTGTAAATAAAA
TTTTATCAACACCAGTTATGGCCATTCTTTCACAGATTCTCTATGGCTCATCACCATGCTATGTTGGCAGAATTAAGTAGCAGCAACAAA
AGCAATATGGCCCACAAGTCTTAAATATATATACTATCTGGTGTTCTGCAGGAAAAGTTCGTCAGCCCCTGCTGTACAAAATTATTTTGA
ATGTTATTCTTAAAAGTAAAGAAATAGAAGAGAGCTAGAAAGTACACTTTCTTTTTGTTTTTTGAGATGGAGTCTCGCTCTTTCGCCCAG
GCCGGACTGCAGTGGCGCGATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG
GATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAAGATGGTCTCGATC
TCCTGACTCATGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCTTGCTCGGCCGAAAGTACACTTTCTTT
ATTCTTAGAGCCCAAACAATCCTTATAGTGATTTTCTGGTCCTTGAGTAAATACCAACTCAAACAGTTTAATAAAAAACCTAATAAGAAA
TGAGTAGTTTGATTTCTGACACTCCATAAACCAATGGAGACAAATATAACTTCTTTAAATGCTTCTTTGGCGGTGCCACAGTTTTTTACT
GTTGCAGTGTGTCATGTAAATCCATTATTCTGACAGTGCTGCTGGTAAAACCGAAGCTGGAATTAATATCCATTATTGAAAGGTCATTGC
ACAGGGATTAGCCAGCAGCCAGTCTTAAAATGTTAATAATGGATATTTTTCAAATATAAAGAAAAGGTCTTACTTTTTTTTATAATTCTC
TAAATGTTTCATTTAAAAGAGAAAATGTTTAAGCAAAAAAAAAAAAAACTAAACTACATAATGCATTTACATGCTGATAACATCAGTAAC

>41203_41203_1_KAT6A-EP300_KAT6A_chr15_41798359_ENST00000265713_EP300_chr3_41521867_ENST00000263253_length(amino acids)=171AA_BP=
MILYPETLLKLLISLRRFWAETVGFSRYTIMSSRFLRDLELEIPFVPAIPLLGIYPKDYKSCCYKDTCTRMFIAAVFTIQRQERMMRPQS

--------------------------------------------------------------
>41203_41203_2_KAT6A-EP300_KAT6A_chr15_41798359_ENST00000396930_EP300_chr3_41521867_ENST00000263253_length(transcript)=11220nt_BP=3583nt
CCAGGCTGCAATGCAGTGGCATGAACATGGCTCACTGCAGCCTGGACCTTGCAGGCTGAAGGAATCCTTCCACCTCAGCCTCCCAAGCTG
GGATTACAGGCATGTGCCACCACGCCAGGCTAATTTTATATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACT
CCTGATCTCAGGTGATCCGCCCGCTTCGGCCTCCCAAAGCAGACGTGGTGGCTCATGCCTATAATTCCAGCACTTTGGGAGGCCAATGCG
GACAAATCACCTGAGGTCAGGAGGTCGAGACCAACCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAGTTAGCCAGGTG
TGGTGGTGGGCACCTATAATCCCAGCTACAGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATT
ACACCATTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCATCTCAAAAATAAATAAATAAATAATAAAAAGACTGACAATAACAAGTG
TTGGCTAGGATTTGTAGCAACTAAAACTCTCATACATTGCTGCTGGGAGTATAAACTGCTACAATTCGGCCTAGGCAACATAGTGAGACC
CCATCTCTACAAAAAAATTTAAAAATTAGCCAGGAGTGGTGGTGTGCACCTGTGATCCCAGCTACTTGGGAGGCTGAAGTCGAAGGATCT
CTTGAGCCTAGGAGATTCAGGCTGCAGTGAGGTAGGATTGCACTGCTTTACTTCATCCTAGACAACAGAGTGAAAGCCCATCTCTATTAA
AAAATCGTACAATTGGTCAGACGCAGTGACTCACACCTGTAATCCCAGCACTTTGGGAGGGTGAGGCGGGTGGATCACCAGAGGTCAGGA
GTTCGAGACCAGCCTGGTCAACATGGCAAAACCTTGTCTCTACTAAAAAATACAAAAATTAGCCAGGCGTGATGGCAGGCGCCTATAATC
CCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGCACCCGGGGGAAAGAGTTTGCAGTGAGCCAAGATCACGCCACTTTATTCCAGC
CTGGATGAAAAGCAAAACTCCATCAAAAAAAAAAAAAAAGAAAAGGGTACAACCCTTTGGATAATACTGGGATTAGAGTCGTGAGTCACT
GTGCCCAGCGGAATATTTCAAACATACATGCAAGTAGAGAGAACAGTATAATGAGTGAATCCCCAGTGTACCTGGCATCCTGCCCCAGCT
ATTCAGGAGGTTGAGGCAGGAGAATCGCTTGAGCTCAGCAAGCAGAGGGAAGCAGAGGTTGCAGTGAGCTGAGGTTGCACCACTGCACTC
CAGCCTGGGCAACAGAGCAGCCTGGGCGACAGAGCGAGACTCTGTCACAAAAAAAAAGGAAACCTACTGAAACAGGCCAGGTGCAGTAGC
TCATGCCTGTAGCCTCCTCTGTGCATAGATCTCGGGCACGGCCCTTCAACGGGCGGCGAAAGCTGCGACTCGATGATTCCTCATTGTAGA
GTTGGGTGGTCCAGGAGGCTTAACTGGAGCCCTTGACCTGAGCGGTAAGGGCAGTCAAAATGGCAGAGCCTGGATTTGAACACAGGCAGT
CCATTTTCATACTGTTTACCTCCCATCCAGGAAAAGGCACATCTGTATACTTCGCTGTTGTCATGCTACAAATAGTAATTAATACAAGTT
CTATGCCAAATTTAAGATGAAATTTTGTAGACAGGTCTTTGCTCACTTCATCCACTTCCTTCAGTTCTCTACTTATCTAAGTTTTCTCTT
TCAATATTGACCTCTATTTTTAACCTTTAGGGATTTTTCCCACCTCTGAAATCGTGTAGCACTGATCTTCTATGCAATTAATTTCATCAC
TGGGATGTACTGCCTTGCAGCCAGCTTGCAGATATCTTTGGCCAGCCCAGCGTTTTTTGTTTTATAATTGATTTATAGTTTATATACCAC
AGAAGTCATCATTTTATTTTATTATTATTATTTTTTTGAGACGGAGCTGCTGCCCGCCTGGCACGGCTCATGTGTGTGTTCCTGGTGGAC
AGTGAGCTGTTCCGGGAGTCCCCAGTACAGCATCTGGTGGCAGCCCTCCTCGCCCAGCTCTGTCAGCCTCAAAGGCATGAACCACCGCAC
CCGGCAAATGATCATTTAAGCAAATGATCGAAGACTCAAGACACAAAACTACCTGAAGGGAGTGGCTCCCACATTTGTAGGGTACCTTAC
AGAGCAATTTCCCTTCATATGATTTTGCAGGTGGGGTGACGGGTGTGGCCGCGACCGCAAGGGCAGCTGTTGCGGGGTTCTCTCTTTCTT
TCATATCCTATTTCCACCCGCCTTAACGTCCTGCGCCTTCTCCCAACACCTTTCAGGCGCCATTCTCTGCTCTAGCCCGGGGTCCCAGGA
GACTTTTCTGCGGTCCGGCTCCCGGGCCCCGCCGATTCCCTCCCCCGCTGCCCGCAGGGTAGCCCGGAGAGCCAGCTCGTCTGCCTCGGG
GAGTCTCGAGCCGTTGAAGACCAGCTGATTACCCCCTCCTCACCTCCTTCACTCCCACTTGTGAACAGACAGCATTTGCATCATGATGCT
GGAGAAGAGAGGGCCACACTGGGATTTCCACCGGGAGATTCCAGCTTCTCCCCCATCCCCCATTTTTGTAGTCAAACTCTCCATCACTCT
CCACTTCCAGGGGGCGACGCTTCAGAGACTGACAACCTCTGGGCTGATGGGGAAGATGGAGTATCCTTCATACAATGATTATAGGCGTGT
GCCACTGTACCCAGCCAAAGGCATGTATTTACTATATCCCAGCCCTACCACACCATATCATATCAGTTCTTTTACTCACAGTCACCGAGA
ACCACGGAGAGGTAGAGATCCGAAGGCACCTCAACTGCAGTCACTGCCCTTTGAGAGACTGCCAATGGCAGGCAGAGCTCCAGCTGGCTG
AATGCCTGTGTACAAAATTAGCTGGGCATGGTGGCGCATGCCTGTAATCCCAGCTACGTGGGAGGCTGAGGCAGAAGAATCACTTGAACC
TGGGAGGCGGAGGTTGTGGTGAGCCGAGATTGCGCCATTGCACTCCAGCCAGGGCGACAGAGTGAGACTCTGTCTCAATAAAAAAAAAAT
ATGATCTGGCGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACAT
GGTGAAACCCTGTGTCTACTAAAAACACAAAAAATAGCTGGGCGTTGTGGCGCTTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAG
GAGAATCACTTGAACCCGAGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCTATTGCACTCCAGCCTGCATGACAGAGTGAGACTTCGTT
TAAAAAAGAAAAAAAATCATGACTCTTGGAGCCCAGGGATTGCCTCCCGCCCAGGGCGTCTGCAGGGACCAGGGAAGTCCTCATCATGCA
CTCCCACCTTGACTCTGGCCCGCATCTGCCCTCTTTTTTGCCCTGGCTCTATGCCAGTGAGCACCACCCTTGCTTTCCACTGAAGAATAC
AGTTGACCCCTGAACAACATGGGTTTGAACTATATCCACTTGAATGCAATTTTCTTCTGCCTCTGCCACTCCTGAGATAGCAAAACCAAC
CTCTCCTCTTCCCTGTCCTCCTCAGTCTACTCAATGTGAAAATAAAAATGAAGACCTTTACGGTGATCCAACCTAGGGTGGGTGCGTTCC
TCCTCTTACTTTTGGGAATGTCCTACTTCGCCTATGAAGTAGCTATTCTTTCACCACTTTACTTAATATATTTGCTTTCACTTTGCACTG
TGGAATCACCCTGAATTCTTTTTTGCATGAGATCCAAGAACCCTCTTTTGGGGGCTGGATCAGGACCCCTTTCTGGTAACACAGGTACCA
CCTAGTTACTGTGCAGCAGCCAGTCTGCACGAGGGCACTGGCTCCCAGGCCACAGCCAGCTGATACATCCTGGTCTCAGCACTACCACAC
CTGAGTGACTTTTTTTTCTTTCTTTTCCTTTTTTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCACCAT
AAAGGAAAATAAATAAGGAAACCTGGTTAAATGCAAAATAACATAATATTCATTCTTTACCTCCTTGCACTTGATCTCCGGATGGCTCTA
AACATATCTGACCTTTTGGAAACTGCCGTTCCTTGGTTTGCTGGACACCTCACTCTTCTGGGTTTCCTCCCTGAACATTCCTTTCCAGTT
TCCTGGAGCTTTTTTCCCTTTACCCCACAATCAAGCATGTGCACGTATCTCATGAATATCAGTCCTCCACACTCCAGCTCCAGCACAGAC
CCACACTTCCAGCCAGAATGTATGTTCATAGCTGACTGTGGTCTCATCATTCGCTCCTGCCTCTGTATTGTGAATACTGCCGCAATAAAC
ATACGTGTGCATGTGTCTTTATAGCAGCATGATTTATAGTCCTTTGGGTATATACCCAGCAATGGGATGGCTGGGACAAATGGTATCTCT
AGTTCTAGATCCCTGAGGAATCGCGACGACATGATTGTGTATCTAGAAAACCCCACTGTCTCAGCCCAAAATCTCCTTAAGCTGATAAGC
AACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCATGGACAAAATTGACAAATGGGATCTAATTGAACTAAAGA
GCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGAACAGGCAACCTACAAAATGGGAGAAAATTTTTGCAACCTACTCATCTGACAAAG
GGCTAATATCCAGAATCTACAATGAACTCAAACAAATGTACAAGAAACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGATCA
AGACCATCTTGGCTAACACGGTGAAACCCCGTCTCGCCAGCACTTATCTTTTATCTTTTAAATAACAGAGATGGGCAGTTTCTTGTAAAG
TTTAAAAGCACATTTACCATATAACCCAGCAATCTCACCTCTAGGTATTTGCTCAGAAGACATAGATTTCCATCTGCAGATGCCAGCTGT
CAGCTCTAGCTCTGCATGGTACCCAACCTTCTTCCAGAACTCTGAAAAACTAAATAATGATGTCTTTTTATATCTTTTCAGATTATATTT
AATTTAAAAGTAGACCACACAGGTTATTTACTGTCTCCCTCACCTAAAACATAAGATAGGGGCCTTTGTTTGTTTTATACATTGTTGTGA
CCAGACCCTAGAATAGCAGCTGAAATTAGTTCTCAAAAAATATTTAAATAAATGAATATGTGAATGACTAAGCAAATGGAAATAAAAGCC
ATTTCTGTTATGACTCAGGCTTGCAGATTGACATATGCAAATATGGAAGTGTAGAGCATAATTTTGAATTTCATTTTCCATCAATGTCTG
ATTACCTACTGATTAAATGTGACAAGCTACAAAGGGAGAAAAATCATTATTAAATTCCAATCTATCATCTATAACCTAAATGCAACTAAT
CATATGTTTAATTTTATATAATAGCTTTCAGACAGAAAAAAATCTACAGGCACAATGTCGTAAAAAATCTCCAGTGAATTTTGTACTATA
TCAAGTGGTCTAACCTAGCTGAAAAGATGGTTAGGCAGATTTCCTAAGTGTGGAAATATAGGAATCTACACTGGAGGAAGAATAGCAGAA
GTTGACAATAATTCATCTAACATTCTTTTCCAGGTTTTGAGCCACACAGTAGAAGCTGTGTAGAAATCCTGGATTGTAGTCATTTTCTTT
CTATTTTAGACCACAGTTCTCCAAAGCAATACACTGGAGTGTGATTTAAAATATATATATATATATATATATATATATATATATATATAT
GAACATGTTTTACAATTATTTTTACCAAAAAGATAATAACTGAAACTGGTCTTTTCCTTGGCACACAGTCTTCAGGTTATCTAAAGTCAG
GACAAAGAAAAGGATCTTAAGAGCTGTGAGGTAAAAGCATCAGGTAACCCATGAAAGAAAAACTATTACAGTAACAACAGATTTAACAGA
TTCACAACTGAATTATATCAGACATTCAGAGAAGAACTGGTACCAACCCTAGTGACACTATTCCATAGAATAAAGAGGAAATCTCCCCTA
AATCATTCTATAAAGCCAGTATCACCCTAATACCAAAACTAGGAAAGGACATAACAAAAAAAGAAAACTACACACCAATATCCCTGATGA
ACACAGATAAAAAAATCCTCAACAAAATAACCAATCCAACAGTGTATCAAAAAGAAGGCACATAGACCAATAAAATATAATAGAGAAACC
AGAAATAAAGCCAAATACTTACTGTTAGTAACTTACTAATCAGCTAACTGATTTGCTAAGGCAGAAGAATGGCTTGAACTCGGGAGGTGG
AGGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGTCTGGGCTGTGCAGCAATGGTGCTATGATTTGAATCTATCCATCCCTCCTCC
AGCACAATTCATCCCAGTAATAACTGTCCTCACTTTAAATGTCCTACCGTTTGCTGAATATGGCAGTAATGTGCTTCAATAATGCTGCCC
CACATGAAAGAAAAACACCCACTGACCAGGAGTGCCACACATTCTACTGTTACACTACTGAAAAACCAAGTACAGTGGCACGATCTCTGC
TCACTGTAACCTCCACCTCCCAGGTTCAAGCGATTCTGCCTCAGCCTCTTGAGTAGCTGAGACTACAGGCATTCACCACCACGCCCGACT
AATTTTTGCATTTTTAGTAGAGATGGAGTTTCATCATGTTGGCCCTAAAAGAATCCAGCACATAATGTCTTACACATATTAGGTTCTCAA
TAAAGATACATGGAGAGAAGGAAGACATGAAGCACGTCACTACTAATAAGATCAGAAGTGGGACAACACATATGTTACAGGGCATTCTGG
GACTGAAGCTAGCCAAAAAACCCCATGCTGCATGATTCTTTTTCTATGATATGTCCAGAATATGCAAATCTATAACGACAAAGTAGCTTA
GTGGTTGTCTAGGCAGAGGTGATTTAGGGGAGAGCAAGACTCTGTCTCCAAAAAGAACAAACAAAAAACAAACAAACAAACAAAACAAAG
GAAGAGGAGCTAAGTCTGAGATAAAGACGGTTAACCAAACTAGGTGAAAGATGAGACTTGAGAGCATTCTGGAAGCTATAACAGGGTCCA
AATAAATATTTCAGTTGCTATTATTTGTTAGAGTCCATTACATAAAGTGCTTTACATACATTATCTCATTTAACTCTTATGAACTTTGTA
AAGAAGACTTAAGCTCTATTTTTATCGACAAGGAAACCAACTTCACAGCCCTCCTGTAAGGACAGAAGAGGGTAACATGTGTACAGCTTT
GAAATAGTATACTCCCTCATCGAGCAGGACACAGAAATAACCAGATAAGGCAGGAGACTGGCCATCACCTCTAGGTAGACTCACCCTGAA
GAAGCACAAAGTGACAGACAATTCAAGCTGGAAATCACTTTTTACTCCTACACTGAAATATTCTCCCAATTCCATTTTTATTTATTTATA
TTTTTGGAGACGGAGTCTCGCTCTGTTGCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGT
GATTCGCCTGCCTCAGCCTCCCGAGGAGCTGGGACTACAGGTGCACGCCACCAAGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGG
TTTCACCACGTTGGCCAAGATGGTCTCGATCTCTTGACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAAAA
ATTAGCCAGGTATGGTGGTGGGCGCCAGTAGTCCCAGCTACCCGGGAAGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTG
CAGTGAGCCGAGATCACTCCACTGTACTCCAGCCTAGGTGACAGAGCAAGACTCCGTCTCAAAAAGAGGGGAGGGGAGGGGAGGGGAGGG
GAGAGGAGGGGAGAGGAGAGGAGAGAAGAAGAAAAAGAAAAGAAAAAGAAAAAGAAAAAAAAAAGAAATAAACATCCTTCTCATCAACAG
TTAGCTGCAAAAAAAAATATTTCTAGCATCTTAAATGTAAGATATTACAAAAGACCAAGTGTGGTATTACTATAATTTAAACTTTACTTG
CATATAATACTGTAAGGTGTTTTATTCCTCCTATAGGTAAACCAAAACAACAAATATTGTTTAAGTAGTTTCAAAGAGGAAAACCAGAGT
CAAATAGAGTAGAAATTACAGAGAAGAAATTTCAGTTCAGTAGAAAGAAACACTTTGTAACAATTAGAATTTTTCAAAGGTGGAGTATGC
TGCCTTGTAGGAAAAAGGATTTTCTAACCCCAGATAGATTCTCACAGTAATCTCTCAAGATGATAGAATACAAGAGATTCCAGTCTAATG
GGAGCTGAGTCTAGTACAATGGTTTTCTAACCTAGATTATGATTATAGCTTCACCTGGGAAGCTTCTAGGCACTCCCCTGAATCTGCTTC
CCAAACCACCGGTCTAATCTATACAAGTTAGCCAACCAAGACAGACAGGTAGACAGTCACAAGTTCCCAAATGATTTTAATGCTTTCAAA
TAGGTTTTGACAAAAATGCACCTGTGTACTCCGACCGCATCAACAAGCTCTGCTGATTTTTCTTACTGCTCTTCCCAGCATTTAATCTAC
TGCAACCACACATTCTACAGGCTATTCCACTGATATGCCAGGTGTGCGCCCACTCTGAGCTTTTGCACTTGCTGTTCTCTTCCCCTGGGT
ATCTGCATGGCTTGCTGCTTCACTGTCTCAAGCTTTTATTTAACAATCACCTTCACCATGAGGCTACCCAGTGAAGGACTTCAACCTCTA
CTCCCATCCAGATACGTCATATCCCCTTTCTTCATTTTATTTATTCTCAGTATTTATTAACTAACATCTAGCATCATCTAACAAACTTAT
CATCTTAATTTTGTTTGTTTTTTATTTTTTCCACAAAAATGTAAGCTCCATGAAGGCAGGGATTTTGGTCAGTTTTATTCATTGCTGTAT
TCTTTGCACATGGAACAATACCTACAAATATCTGTTCAATGACTTAATGAACTAGATCTGGGGTGGCAAACTCTAGATCTGGGATAAAGT
TTTACTGGAACACAGTCACACATTCATTTATATATTGTCTACAGCTGTTTTTGTGCTACAAGAGTGGATTTAAATAGTTGTACCAGAGAC
TGTATGGCCCATAAAGCTTAAAATATTTCTTGTCGAGACTTTTACAGAATAAAATTTGCCAATCCCTGAACTAGATGCACCAATCAGAAT
GTCATGTAGAGTTCCGATTCCAAACTTCTAGGTAACTGTGGTAGATTAAAGATGGCCACAAATTACTGTCATTAAGAGCTAGAGTCTCTT
TCTCCACCCCTTGAACCAATATGGCTTAGTGATTCTCTCAACCAATAAAATGTGATGAAATTAACATGAGATTTCCAAGCCTAGGCAGCA
AGAGGCCTTGCAGCTTCCACTCAGGCCGTCTTCAAATACTGCCACCATGTTTAAAAACCTGAGCTAGCCTCCTTGAGTATAAGAGATCAT
GTAGAGAGAGAGGTCCACCCTCCCCATACTGAGGCTCCCAGTATGTGAGCAAGCCCAGCTGACACTGTGGAGCCCAGATCATGCTGCCAA
AGCACACAACACACCACGGAGCCCAGACCATGCTGCCAAAGCACACAACAGTGAGCAAATATGTGTTATTTTAAGTCGCTTAGCTTTGGA
TGGTTTATTATGTAGGAGAAGTTATTTGACATAGTAAAATTTATTTATTATTTTTAGACTAAATCCTTAGATTTTCCCTTTTTCCTTCAT
ACATCTCCATACTACTGTGGGAGCAGCAGCCTCAATCTCAAATTATTTACTCACATGTAATGTCCCTGTTACTTCAGTTAAATCACAATT
TAATAACTAAATTTTATAAATATGTTGACGCGTGAAGATTTGAGAGTAGTTTGGGAAGCGTTTGAATTAGTTATTGGACAGAGGTTGGCA
AGCCATGGCCTGTGGGCTACCCACCTAATTCTGTAAATAAAATTTTATCAACACCAGTTATGGCCATTCTTTCACAGATTCTCTATGGCT
CATCACCATGCTATGTTGGCAGAATTAAGTAGCAGCAACAAAAGCAATATGGCCCACAAGTCTTAAATATATATACTATCTGGTGTTCTG
CAGGAAAAGTTCGTCAGCCCCTGCTGTACAAAATTATTTTGAATGTTATTCTTAAAAGTAAAGAAATAGAAGAGAGCTAGAAAGTACACT
TTCTTTTTGTTTTTTGAGATGGAGTCTCGCTCTTTCGCCCAGGCCGGACTGCAGTGGCGCGATCTTGGCTCACTGCAAGCTCCGCCTCCT
GGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAG
TAGAGACGGGGTTTCACCGTGTTAGCCAAGATGGTCTCGATCTCCTGACTCATGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTA
CAGGCGTGAGCCACCTTGCTCGGCCGAAAGTACACTTTCTTTATTCTTAGAGCCCAAACAATCCTTATAGTGATTTTCTGGTCCTTGAGT
AAATACCAACTCAAACAGTTTAATAAAAAACCTAATAAGAAATGAGTAGTTTGATTTCTGACACTCCATAAACCAATGGAGACAAATATA
ACTTCTTTAAATGCTTCTTTGGCGGTGCCACAGTTTTTTACTGTTGCAGTGTGTCATGTAAATCCATTATTCTGACAGTGCTGCTGGTAA
AACCGAAGCTGGAATTAATATCCATTATTGAAAGGTCATTGCACAGGGATTAGCCAGCAGCCAGTCTTAAAATGTTAATAATGGATATTT
TTCAAATATAAAGAAAAGGTCTTACTTTTTTTTATAATTCTCTAAATGTTTCATTTAAAAGAGAAAATGTTTAAGCAAAAAAAAAAAAAA

>41203_41203_2_KAT6A-EP300_KAT6A_chr15_41798359_ENST00000396930_EP300_chr3_41521867_ENST00000263253_length(amino acids)=171AA_BP=
MILYPETLLKLLISLRRFWAETVGFSRYTIMSSRFLRDLELEIPFVPAIPLLGIYPKDYKSCCYKDTCTRMFIAAVFTIQRQERMMRPQS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KAT6A-EP300

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000265713		15	17	144_664	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000396930		16	18	144_664	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000406337		16	18	144_664	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000265713		15	17	312_664	1013.0	2005.0	RUNX1-1
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000396930		16	18	312_664	1013.0	2005.0	RUNX1-1
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000406337		16	18	312_664	1013.0	2005.0	RUNX1-1
Tgene	EP300	chr15:41798359	chr3:41521867	ENST00000263253		1	31	1397_1399	243.0	2415.0	histone
Tgene	EP300	chr15:41798359	chr3:41521867	ENST00000263253		1	31	2003_2212	243.0	2415.0	HTLV-1 Tax
Tgene	EP300	chr15:41798359	chr3:41521867	ENST00000263253		1	31	2041_2240	243.0	2415.0	NCOA2

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000265713		15	17	1517_1741	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000396930		16	18	1517_1741	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000406337		16	18	1517_1741	1013.0	2005.0	PML
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000265713		15	17	1517_1642	1013.0	2005.0	RUNX1-2
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000396930		16	18	1517_1642	1013.0	2005.0	RUNX1-2
Hgene	KAT6A	chr15:41798359	chr3:41521867	ENST00000406337		16	18	1517_1642	1013.0	2005.0	RUNX1-2
Tgene	EP300	chr15:41798359	chr3:41521867	ENST00000263253		1	31	2_139	243.0	2415.0	ALX1
Tgene	EP300	chr15:41798359	chr3:41521867	ENST00000263253		1	31	2_149	243.0	2415.0	RORA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KAT6A-EP300

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KAT6A-EP300

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source