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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:KAT6A-NCOA2 (FusionGDB2 ID:41213)

Fusion Gene Summary for KAT6A-NCOA2

Fusion gene summary

Fusion gene information	Fusion gene name: KAT6A-NCOA2
	Fusion gene ID: 41213
		Hgene	Tgene
	Gene symbol	KAT6A	NCOA2
	Gene ID	7994	10499
	Gene name	lysine acetyltransferase 6A	nuclear receptor coactivator 2
	Synonyms	ARTHS\|MOZ\|MRD32\|MYST-3\|MYST3\|RUNXBP2\|ZC2HC6A\|ZNF220	GRIP1\|KAT13C\|NCoA-2\|SRC2\|TIF2\|bHLHe75
	Cytomap	8p11.21	8q13.3
	Type of gene	protein-coding	protein-coding
	Description	histone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription	nuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2
	Modification date	20200313	20200313
	UniProtAcc	Q92794	Q15596
	Ensembl transtripts involved in fusion gene	ENST00000265713, ENST00000396930, ENST00000406337, ENST00000485568,	ENST00000267974, ENST00000524223, ENST00000452400,
Fusion gene scores	* DoF score	26 X 32 X 13=10816	19 X 24 X 6=2736
	# samples	42	12
	** MAII score	log2(42/10816*10)=-4.68663391861606 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/2736*10)=-4.51096191927738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KAT6A [Title/Abstract] AND NCOA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KAT6A(41794848)-NCOA2(71053441), # samples:1 KAT6A(41794774)-NCOA2(71057084), # samples:1
Anticipated loss of major functional domain due to fusion event.	KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KAT6A	GO:0006473	protein acetylation	23431171
Hgene	KAT6A	GO:0016573	histone acetylation	11742995\|17925393
Hgene	KAT6A	GO:0030099	myeloid cell differentiation	11742995
Hgene	KAT6A	GO:0043966	histone H3 acetylation	16387653
Hgene	KAT6A	GO:0045892	negative regulation of transcription, DNA-templated	11742995
Hgene	KAT6A	GO:0045893	positive regulation of transcription, DNA-templated	11742995\|11965546\|18794358

Fusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NCOA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	biphenotypic leukemia;acute lymphoblastic leukemia;lymphoblastic lymphoma	EF374064	KAT6A	chr8	41794848		NCOA2	chr8	71053441
ChimerKB3	.	.	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
ChiTaRS5.0	N/A	EF374064	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-

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Fusion Gene ORF analysis for KAT6A-NCOA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265713	ENST00000267974	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
5CDS-intron	ENST00000265713	ENST00000524223	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
5CDS-intron	ENST00000396930	ENST00000267974	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
5CDS-intron	ENST00000396930	ENST00000524223	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
5CDS-intron	ENST00000406337	ENST00000267974	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
5CDS-intron	ENST00000406337	ENST00000524223	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
Frame-shift	ENST00000406337	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
In-frame	ENST00000265713	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
In-frame	ENST00000396930	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
intron-3CDS	ENST00000265713	ENST00000267974	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000265713	ENST00000452400	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000396930	ENST00000267974	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000396930	ENST00000452400	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000406337	ENST00000267974	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000406337	ENST00000452400	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000485568	ENST00000267974	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000485568	ENST00000452400	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-3CDS	ENST00000485568	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
intron-intron	ENST00000265713	ENST00000267974	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000265713	ENST00000452400	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000265713	ENST00000524223	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-intron	ENST00000265713	ENST00000524223	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000396930	ENST00000267974	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000396930	ENST00000452400	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000396930	ENST00000524223	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-intron	ENST00000396930	ENST00000524223	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000406337	ENST00000267974	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000406337	ENST00000452400	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000406337	ENST00000524223	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-intron	ENST00000406337	ENST00000524223	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000485568	ENST00000267974	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000485568	ENST00000267974	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-
intron-intron	ENST00000485568	ENST00000452400	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000485568	ENST00000524223	KAT6A	chr8	41794848		NCOA2	chr8	71053441
intron-intron	ENST00000485568	ENST00000524223	KAT6A	chr8	41914005		NCOA2	chr8	71215994	-
intron-intron	ENST00000485568	ENST00000524223	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265713	KAT6A	chr8	41794774	-	ENST00000452400	NCOA2	chr8	71057084	-	9424	3764	412	5553	1713
ENST00000396930	KAT6A	chr8	41794774	-	ENST00000452400	NCOA2	chr8	71057084	-	9556	3896	544	5685	1713

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265713	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-	0.000190915	0.9998091
ENST00000396930	ENST00000452400	KAT6A	chr8	41794774	-	NCOA2	chr8	71057084	-	0.000220514	0.9997795

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Fusion Genomic Features for KAT6A-NCOA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KAT6A-NCOA2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41794848/chr8:71053441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KAT6A Q92794	NCOA2 Q15596
FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269\|PubMed:11742995, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:12771199, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:17925393, ECO:0000269\|PubMed:23431171}.	FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250\|UniProtKB:Q61026, ECO:0000269\|PubMed:23508108, ECO:0000269\|PubMed:9430642}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1019_1026

1117

2005.0

Compositional bias

Note=Poly-Arg

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1069_1078

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

371_379

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

788_801

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

989_995

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1019_1026

1117

2005.0

Compositional bias

Note=Poly-Arg

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1069_1078

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

371_379

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

788_801

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

989_995

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1019_1026

1117

2005.0

Compositional bias

Note=Poly-Arg

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1069_1078

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

371_379

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

788_801

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

989_995

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

504_778

1117

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

95_171

1117

2005.0

Domain

H15

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

504_778

1117

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

95_171

1117

2005.0

Domain

H15

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

504_778

1117

2005.0

Domain

MYST-type HAT

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

95_171

1117

2005.0

Domain

H15

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1_144

1117

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

488_778

1117

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

52_166

1117

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

645_649

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

654_660

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1_144

1117

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

488_778

1117

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

52_166

1117

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

645_649

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

654_660

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1_144

1117

2005.0

Region

Note=Required for activation of RUNX1-1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

488_778

1117

2005.0

Region

Note=Catalytic

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

52_166

1117

2005.0

Region

Note=Required for nuclear localization

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

645_649

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

654_660

1117

2005.0

Region

Acetyl-CoA binding

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

206_265

1117

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

259_313

1117

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

537_562

1117

2005.0

Zinc finger

C2HC MYST-type

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

206_265

1117

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

259_313

1117

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

537_562

1117

2005.0

Zinc finger

C2HC MYST-type

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

206_265

1117

2005.0

Zinc finger

PHD-type 1

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

259_313

1117

2005.0

Zinc finger

PHD-type 2

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

537_562

1117

2005.0

Zinc finger

C2HC MYST-type

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

1254_1260

868

1465.0

Compositional bias

Note=Poly-Gln

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

1079_1087

868

1465.0

Motif

Note=LLXXLXXXL motif

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

878_882

868

1465.0

Motif

Note=LXXLL motif 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1147_1150

1117

2005.0

Compositional bias

Note=Poly-Lys

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1221_1242

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1267_1302

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1411_1414

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1593_1597

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1643_1704

1117

2005.0

Compositional bias

Note=Gln/Pro-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1897_1977

1117

2005.0

Compositional bias

Note=Met-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1147_1150

1117

2005.0

Compositional bias

Note=Poly-Lys

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1221_1242

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1267_1302

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1411_1414

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1593_1597

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1643_1704

1117

2005.0

Compositional bias

Note=Gln/Pro-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1897_1977

1117

2005.0

Compositional bias

Note=Met-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1147_1150

1117

2005.0

Compositional bias

Note=Poly-Lys

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1221_1242

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1267_1302

1117

2005.0

Compositional bias

Note=Glu-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1411_1414

1117

2005.0

Compositional bias

Note=Poly-Glu

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1593_1597

1117

2005.0

Compositional bias

Note=Poly-Ser

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1643_1704

1117

2005.0

Compositional bias

Note=Gln/Pro-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1897_1977

1117

2005.0

Compositional bias

Note=Met-rich

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000265713

1913_1948

1117

2005.0

Region

Note=Required for activation of RUNX1-2

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000396930

1913_1948

1117

2005.0

Region

Note=Required for activation of RUNX1-2

Hgene

KAT6A

chr8:41794774

chr8:71057084

ENST00000406337

1913_1948

1117

2005.0

Region

Note=Required for activation of RUNX1-2

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

119_183

868

1465.0

Domain

PAS

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

26_83

868

1465.0

Domain

bHLH

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

641_645

868

1465.0

Motif

Note=LXXLL motif 1

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

690_694

868

1465.0

Motif

Note=LXXLL motif 2

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

745_749

868

1465.0

Motif

Note=LXXLL motif 3

Tgene

NCOA2

chr8:41794774

chr8:71057084

ENST00000452400

691_743

868

1465.0

Region

CASP8AP2-binding

Top

Fusion Gene Sequence for KAT6A-NCOA2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41213_41213_1_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000265713_NCOA2_chr8_71057084_ENST00000452400_length(transcript)=9424nt_BP=3764nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGCA
TAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTG
AGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAA
GGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTAC
TCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGAT
TTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGA
TCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGA
TCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGAT
AAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGC
ATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGA
TGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCT
TCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAA
GCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAA
GGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTC
ATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAG
GAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAA
GAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCA
ATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAA
CAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTA
CTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAA
ACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACT
GCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTA
CTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCTTTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCT
GCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGAGATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGG
GAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTTGTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATT
TCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGTTGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAA
TGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGGCAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGA
AGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCTTTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCT
TTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTTGACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCA
CCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCGGGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAA
TTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGTCATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGA
GGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATTAGAGATCAGTGTGGGAAAGTCTGTGTCTCATGAGAACAAAGA
ACAAGATTCTTATTCAGTAGAAAGTGAAAAGAAACCAGAAGTTATGGCTCCAGTCAGTTCTACACGTTTGAGCAAACAAGTCCTTCCTCA
TGATAGTCTTCCTGCAAATAGCCAGCCATCTCGGAGGGGCCGCTGGGGGAGGAAGAACAGAAAAACCCAGGAACGTTTTGGTGATAAAGA
TTCTAAACTGCTCTTGGAAGAGACGTCTTCAGCTCCTCAGGAACAATATGGAGAATGTGGGGAGAAATCAGAAGCCACCCAGGAACAATA
CACTGAAAGTGAAGAACAGCTGGTGGCTTCTGAGGAGCAGCCAAGCCAGGACGGGAAACCTGACCTTCCCAAGAGAAGACTCAGTGAGGG
GGTTGAGCCCTGGCGAGGACAGCTCAAGAAAAGCCCTGAGGCTCTGAAGTGCAGATTAACAGAAGGAAGTGAGAGGCTGCCCCGTCGCTA
CAGTGAGGGTGACAGGGCTGTCCTCAGGGGCTTCAGTGAGAGCAGCGAGGAGGAGGAGGAGCCGGAAAGCCCTCGGTCAAGCTCGCCACC
AATTCTCACAAAGCCCACGCTGAAGCGAAAGAAACCATTTCTCCACCGAAGGAGGAGAGTCCGAAAGCGCAAACACCACAATAGCAGTGT
AGTCACAGAAACTATTTCTGAGACCACTGAAGTGTTAGATGAACCTTTTGAAGATTCTGACTCCGAGAGGCCAATGCCAAGATTAGAACC
CACGTTTGAGATCGATGAAGAAGAGGAGGAAGAGGATGAAAATGAACTTTTCCCTAGAGAATACTTCCGTCGTTTGTCTTCGCAGGATGT
ACTCAGGTGTCAGTCCTCTTCTAAGAGGAAGTCTAAAGATGAAGAAGAAGATGAAGAGTCAGATGATGCTGATGCTTTTAATAACCCACG
ACCAGGGCAACTGGGCAGGTTATTGCCAAACCAGAATTTACCACTTGACATCACATTGCAAAGCCCAACTGGTGCTGGACCTTTCCCACC
AATCAGAAACAGTAGTCCCTACTCAGTGATACCTCAGCCAGGAATGATGGGTAATCAAGGGATGATAGGAAACCAAGGAAATTTAGGGAA
CAGTAGCACAGGAATGATTGGTAACAGTGCTTCTCGGCCTACTATGCCATCTGGAGAATGGGCACCGCAGAGTTCGGCTGTGAGAGTCAC
CTGTGCTGCTACCACCAGTGCCATGAACCGGCCAGTCCAAGGAGGTATGATTCGGAACCCAGCAGCCAGCATCCCCATGAGGCCCAGCAG
CCAGCCTGGCCAAAGACAGACGCTTCAGTCTCAGGTCATGAATATAGGGCCATCTGAATTAGAGATGAACATGGGGGGACCTCAGTATAG
CCAACAACAAGCTCCTCCAAATCAGACTGCCCCATGGCCTGAAAGCATCCTGCCTATAGACCAGGCGTCTTTTGCCAGCCAAAACAGGCA
GCCATTTGGCAGTTCTCCAGATGACTTGCTATGTCCACATCCTGCAGCTGAGTCTCCGAGTGATGAGGGAGCTCTCCTGGACCAGCTGTA
TCTGGCCTTGCGGAATTTTGATGGCCTGGAGGAGATTGATAGAGCCTTAGGAATACCCGAACTGGTCAGCCAGAGCCAAGCAGTAGATCC
AGAACAGTTCTCAAGTCAGGATTCCAACATCATGCTGGAGCAGAAGGCGCCCGTTTTCCCACAGCAGTATGCATCTCAGGCACAAATGGC
CCAGGGTAGCTATTCTCCCATGCAAGATCCAAACTTTCACACCATGGGACAGCGGCCTAGTTATGCCACACTCCGTATGCAGCCCAGACC
GGGCCTCAGGCCCACGGGCCTAGTGCAGAACCAGCCAAATCAACTAAGACTTCAACTTCAGCATCGCCTCCAAGCACAGCAGAATCGCCA
GCCACTTATGAATCAAATCAGCAATGTTTCCAATGTGAACTTGACTCTGAGGCCTGGAGTACCAACACAGGCACCTATTAATGCACAGAT
GCTGGCCCAGAGACAGAGGGAAATCCTGAACCAGCATCTTCGACAGAGACAAATGCATCAGCAACAGCAAGTTCAGCAACGAACTTTGAT
GATGAGAGGACAAGGGTTGAATATGACACCAAGCATGGTGGCTCCTAGTGGTATGCCAGCAACTATGAGCAACCCTCGGATTCCCCAGGC
AAATGCACAGCAGTTTCCATTTCCTCCAAACTACGGAATAAGTCAGCAACCTGATCCAGGCTTTACTGGGGCTACGACTCCCCAGAGCCC
ACTTATGTCACCCCGAATGGCACATACACAGAGTCCCATGATGCAACAGTCTCAGGCCAACCCAGCCTATCAGGCCCCCTCCGACATAAA
TGGATGGGCGCAGGGGAACATGGGCGGAAACAGCATGTTTTCCCAGCAGTCCCCACCACACTTTGGGCAGCAAGCAAACACCAGCATGTA
CAGTAACAACATGAACATCAATGTGTCCATGGCGACCAACACAGGTGGCATGAGCAGCATGAACCAGATGACAGGACAGATCAGCATGAC
CTCAGTGACCTCCGTGCCTACGTCAGGGCTGTCCTCCATGGGTCCCGAGCAGGTTAATGATCCTGCTCTGAGGGGAGGCAACCTGTTCCC
AAACCAGCTGCCTGGAATGGATATGATTAAGCAGGAGGGAGACACAACACGGAAATATTGCTGACACTGCTGAAGCCAGTTGCTTCTTCA
GCTGACCGGGCTCACTTGCTCAAAACACTTCCAGTCTGGAGAGCTGTGTCTATTTGTTTCAACCCAACTGACCTGCCAGCCGGTTCTGCT
AGAGCAGACAGGCCTGGCCCTGGTTCCCAGGGTGGCGTCCACTCGGCTGTGGCAGGAGGAGCTGCCTCTTCTCTTGACAGTCTGAAGCTC
GCATCCAGACAGTCGCTCAGTCTGTTCACTGCATTCACCTTAGTGCAACTTAGATCTCTCCTGCAAAAGTAAATGTTGACAGGCAAATTT
CATACCCATGTCAGATTGAATGTATTTAAATGTATGTATTTAAGGAGAACCATGCTCTTGTTCTGTTCCTGTTCGGTTCCAGACACTGGT
TTCTTGCTTTGTTTTCCCTGGCTAACAGTCTAGTGCAAAAGATTAAGATTTTATCTGGGGGAAAGAAAAGAATTTTTTAAAAAATTAAAC
TAAAGATGTTTTAAGCTAAAGCCTGAATTTGGGATGGAAGCAGGACAGACACCGTGGACAGCGCTGTATTTACAGACACACCCAGTGCGT
GAAGACCAACAAAGTCACAGTCGTATCTCTAGAAAGCTCTAAAGACCATGTTGGAAAGAGTCTCCAGTTACTGAACAGATGAAAAGGAGC
CTGTGAGAGGGCTGTTAACATTAGCAAATATTTTTTCCTTGTTTTTTCTTTGTTAAAACCAAACTGGTTCACCTGAATCATGAATTGAGA
AGAAATAATTTTCATTTCTAAATTAAGTCCCTTTTAGTTTGATCAGACAGCTTGAATCAGCATCTCTTCTTCCCTGTCAGCCTGACTCTT
CCCTTCCCCTCTCTCATTCCCCATACTCCCTATTTTCATTCCTTTTTTAAAAAATAATATAAGCTACAGAAACCAGGTAAGCCCTTTATT
TCCTTAAATGTTTTGCCAGCCACTTACCAATTGCTAAGTATTGAATTTCAGAAAAAAAAAATGCATTTACTGGCAAGGAGAAGAGCAAAG
TTAAGGCTTGATACCAATCGAGCTAAGGATACCTGCTTTGGAAGCATGTTTATTCTGTTCCCCAGCAACTCTGGCCTCCAAAATGGGAGA
AAACGCCAGTGTGTTTAAATTGATAGCAGATATCACGACAGATTTAACCTCTGCCATGTGTTTTTTATTTTGTTTTTTAGCAGTGCTGAC
TAAGCCGAAGTTTTGTAAGGTACATAAAATCCAATTTATATGTAAACAAGCAATAATTTAAGTTGAGAACTTATGTGTTTTAATTGTATA
ATTTTTGTGAGGTATACATATTGTGGAATTGACTCAAAAATGAGGTACTTCAGTATTAAATTAGATATCTTCATAGCAATGTCTCCTAAA
GGTGTTTTGTAAAGGATATCAATGCCTTGATTAGACCTAATTTGTAGACTTAAGACTTTTTATTTTCTAAACCTTGTGATTCTGCTTATA
AGTCATTTATCTAATCTATATGATATGCAGCCGCTGTAGGAACCAATTCTTGATTTTTATATGTTTATATTCTTTCTTAATGAACCTTAG
AAAGACTACATGTTACTAAGCAGGCCACTTTTATGGTTGTTTTTCTTGCCCACTCTGGTAGGGGAAAAATCTTTTATTAATAGGTGTCAG
TTTCAGACAACTCCAATACCAAGAAACTGATGACCTTTTTTGAGCTATTTCTCCTTAACCCCTAATACCTTTCTTACCTAAATTTCAGAA
TGATATCTTTTTGATGTCTAAAAAGCAAAGCATTTTATAATATCTCATTAGCCAGGCTTTTTAGGAACAGAGAAGTTTTTCCTTGAAATT
TGATTGTTTGTTTATTTGTGGCAGGGTGAAAAATGTACAAACTACCCCTATTTATACTTATATCTCTCTCTATATGTACGCATTATGGAA
ATATAGGAAGAGATATAGCCCAAAGATAGATGGTAAGTAGACAGTCTGAAAATGTTGCTCCATACTAAAGAACCTTTCTGGAAATTTGCA
TTTCGCTACTTTTTTCCACTTGAGAGGGGTCTCAATACAGGGAGGTGGCCAAGGAACAACACTTCTCAGTGGCCACCAGTTCATATATCC
CCTCAAAAGGCTCTACTTTTCTCCACCAAACCATTGGGTTGCCCAACTGTGATGGAAAAAACAAGCAGATGTTGGCCCAGAACTCCAGGA
CCTCCCCGTGGGCTGAGGCTCATGTGGCATACAATTCAGTGTGACCAGTTTTAATGTTCAGAAATATGTGAATTAGAATGACTTTTAACT
TCACACAGCACAAAAGAGAAATGGAGTTTAAACTGGATTTGTTTTGTTTTGAGTTTCAAGTCCCTTTTCACTACAACACCGTCCAAAACT
ATCTACCTATCTCTTCTTTTTTATCCATCTGCCCGCTGTATTTTAATGTCAATCCTAATTCAGACAAATCCGCAACTTCATGATACTGGT
AATTTATAATAATTCGTGATCATTGCTGTTTTGAAGGAAAAGAGATGATAAATTCTCTTACGGTTTCAATCAGGTAATGGATTTTGTTTT
ACATCTAGTTAGGAGAAGAAAAGTAAGTGAAGGAATCCTCTGATCATATTGATCACTATAGAAGCAAAAGCCAAATCAGTTCCCTTCATT
ATCAGTATTTCTCATGCTGTACACAATAAATTTGTTAGACTGAGTACTTGGTTTTTGTTTAATAGAACAAATAATCAGTGTTTCACTTAT
ATTACTAAATGTGAAAAACATAATGTGAAAAGTATACATACATTAACTTGGTTGTAAAACTCATTTTAAGTGTTCATGTAATGTGGTAAG
TTTAAAAAGTGAAGTGAGCTGTTTTACTACAATGAATTCGTTTGACTCAAAGATTAAAATGCCCCTCCCCCTATGTGTATCTCTTATGGC
CTGTAATAATTGAAAGCAATGTTTTTGCAGTTTATATAATGCAATTTTTAATCTGTGTTCAAAAATGGAGTTCATATGGGCTTAACACAT
GAAATGGGTGGCACAGATCCACTTGCAGAACCCAAAGATACACAATCAGTTTTGAAATGCAACTTAAGCCATTAATTGTTGGTGTGAATT
TAAAATTTTCTAGTGTTTGTATGGTGGTATGCTGCCTAAGAGCAAAGCATCCTCTGCACAAAAGAAAATTACTGTAGTGGCTTCGATTTT
AATTAGAATTTTCTCCCTGGTGTTTCTTTATAGACTAAAGCAAAATCTTTTAAGTTTCTTACTACAGGTAAAAGCTATGTGCAAGAACCT
CAAAATGCTAAAATCTAGCATAATGCCTTAGATCTGTTTTTAAGTCTTGTATATTCCTACATAGCTGTCCGATGTATTATATTTGTATAG
TGAATTGTGTACAATTTTTGAATAAGTGCATCATCACTTAACCTTTATGTTGTTTGAATAGTGATGATGATACATTTCTTCAGACATTTA
ACTGTCATTTTTTTCCTTTGTCATTTGTGAGTTTTATTTGTACAGTTCCTCATGAAGTTGCATCTGAGATGTGTGTATATGAAAAGATTA
TACAAGGGTAAAATTAAGCAATATATTAACTATGGTTCTTCAGGAGAAAGCTTACAGTGTTTCAGGTTGTGATTTATTTTCAAAATGGAG
TTGACTCTGAACATCACTTTGTTCACCTGCATTGATGTTTGTATTTCTAGTGTGAGCAGTTTATGCAAAGGTAGATATATTCAGAGAAAT
TTTAAATACATTTATGCAAGTTAATATTGCTTTGCTGATGCTATTTGCTTATTTGATGTTAAATAATGCTATTGTAAATAAAGAATTCTG

>41213_41213_1_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000265713_NCOA2_chr8_71057084_ENST00000452400_length(amino acids)=1713AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMG
NQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGP
SELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALG
IPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRL
QLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSG
MPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQS
PPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTR

--------------------------------------------------------------
>41213_41213_2_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000396930_NCOA2_chr8_71057084_ENST00000452400_length(transcript)=9556nt_BP=3896nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGTGAG
CAGAGATTGCGGAGTACAGAATAGCCATCACCCACTCTGGCATAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGA
GTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTT
GGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTT
CCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTT
CACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGA
AGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAAC
AATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGG
AAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAA
AAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATT
GGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAA
AGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTG
TAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCC
ATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCG
AGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCG
TATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACG
GCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGG
CCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGG
CTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCC
TTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCAC
TTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGA
GAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCC
CTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACTCCTCCCCATATCCTCAAGAATACTCAAGGCTGCCCAAATTGTATCT
TTGTGAATTTTGTCTAAAATATATGAAAAGTAGAACTATTCTGCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTCCTGCCAATGA
GATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGGGAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTT
GTTTCTTGACCACAAAACCCTCTATTACGATGTGGAGCCATTTCTTTTTTATGTACTAACACAGAATGATGTCAAGGGCTGCCACCTTGT
TGGCTACTTTTCTAAGGAAAAGCACTGCCAACAGAAGTACAATGTTTCCTGTATAATGATTCTTCCTCAATACCAGCGTAAGGGCTATGG
CAGGTTTCTCATCGATTTCAGTTATTTGTTATCAAAGCGTGAAGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTGGGTCGTCT
TTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCTTTATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTT
GACTGGAATCTGCCCTCAAGACATCACTTCCACACTCCACCACCTACGAATGCTGGACTTCCGTAGTGACCAATTTGTGATTATCCGCCG
GGAAAAACTTATCCAGGATCACATGGCAAAGCTTCAGCTGAATTTGCGACCTGTAGATGTAGATCCAGAATGTTTGCGCTGGACTCCAGT
CATAGTGTCCAACTCTGTGGTCTCAGAGGAGGAAGAAGAGGAGGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAGGAAAGAGAATT
AGAGATCAGTGTGGGAAAGTCTGTGTCTCATGAGAACAAAGAACAAGATTCTTATTCAGTAGAAAGTGAAAAGAAACCAGAAGTTATGGC
TCCAGTCAGTTCTACACGTTTGAGCAAACAAGTCCTTCCTCATGATAGTCTTCCTGCAAATAGCCAGCCATCTCGGAGGGGCCGCTGGGG
GAGGAAGAACAGAAAAACCCAGGAACGTTTTGGTGATAAAGATTCTAAACTGCTCTTGGAAGAGACGTCTTCAGCTCCTCAGGAACAATA
TGGAGAATGTGGGGAGAAATCAGAAGCCACCCAGGAACAATACACTGAAAGTGAAGAACAGCTGGTGGCTTCTGAGGAGCAGCCAAGCCA
GGACGGGAAACCTGACCTTCCCAAGAGAAGACTCAGTGAGGGGGTTGAGCCCTGGCGAGGACAGCTCAAGAAAAGCCCTGAGGCTCTGAA
GTGCAGATTAACAGAAGGAAGTGAGAGGCTGCCCCGTCGCTACAGTGAGGGTGACAGGGCTGTCCTCAGGGGCTTCAGTGAGAGCAGCGA
GGAGGAGGAGGAGCCGGAAAGCCCTCGGTCAAGCTCGCCACCAATTCTCACAAAGCCCACGCTGAAGCGAAAGAAACCATTTCTCCACCG
AAGGAGGAGAGTCCGAAAGCGCAAACACCACAATAGCAGTGTAGTCACAGAAACTATTTCTGAGACCACTGAAGTGTTAGATGAACCTTT
TGAAGATTCTGACTCCGAGAGGCCAATGCCAAGATTAGAACCCACGTTTGAGATCGATGAAGAAGAGGAGGAAGAGGATGAAAATGAACT
TTTCCCTAGAGAATACTTCCGTCGTTTGTCTTCGCAGGATGTACTCAGGTGTCAGTCCTCTTCTAAGAGGAAGTCTAAAGATGAAGAAGA
AGATGAAGAGTCAGATGATGCTGATGCTTTTAATAACCCACGACCAGGGCAACTGGGCAGGTTATTGCCAAACCAGAATTTACCACTTGA
CATCACATTGCAAAGCCCAACTGGTGCTGGACCTTTCCCACCAATCAGAAACAGTAGTCCCTACTCAGTGATACCTCAGCCAGGAATGAT
GGGTAATCAAGGGATGATAGGAAACCAAGGAAATTTAGGGAACAGTAGCACAGGAATGATTGGTAACAGTGCTTCTCGGCCTACTATGCC
ATCTGGAGAATGGGCACCGCAGAGTTCGGCTGTGAGAGTCACCTGTGCTGCTACCACCAGTGCCATGAACCGGCCAGTCCAAGGAGGTAT
GATTCGGAACCCAGCAGCCAGCATCCCCATGAGGCCCAGCAGCCAGCCTGGCCAAAGACAGACGCTTCAGTCTCAGGTCATGAATATAGG
GCCATCTGAATTAGAGATGAACATGGGGGGACCTCAGTATAGCCAACAACAAGCTCCTCCAAATCAGACTGCCCCATGGCCTGAAAGCAT
CCTGCCTATAGACCAGGCGTCTTTTGCCAGCCAAAACAGGCAGCCATTTGGCAGTTCTCCAGATGACTTGCTATGTCCACATCCTGCAGC
TGAGTCTCCGAGTGATGAGGGAGCTCTCCTGGACCAGCTGTATCTGGCCTTGCGGAATTTTGATGGCCTGGAGGAGATTGATAGAGCCTT
AGGAATACCCGAACTGGTCAGCCAGAGCCAAGCAGTAGATCCAGAACAGTTCTCAAGTCAGGATTCCAACATCATGCTGGAGCAGAAGGC
GCCCGTTTTCCCACAGCAGTATGCATCTCAGGCACAAATGGCCCAGGGTAGCTATTCTCCCATGCAAGATCCAAACTTTCACACCATGGG
ACAGCGGCCTAGTTATGCCACACTCCGTATGCAGCCCAGACCGGGCCTCAGGCCCACGGGCCTAGTGCAGAACCAGCCAAATCAACTAAG
ACTTCAACTTCAGCATCGCCTCCAAGCACAGCAGAATCGCCAGCCACTTATGAATCAAATCAGCAATGTTTCCAATGTGAACTTGACTCT
GAGGCCTGGAGTACCAACACAGGCACCTATTAATGCACAGATGCTGGCCCAGAGACAGAGGGAAATCCTGAACCAGCATCTTCGACAGAG
ACAAATGCATCAGCAACAGCAAGTTCAGCAACGAACTTTGATGATGAGAGGACAAGGGTTGAATATGACACCAAGCATGGTGGCTCCTAG
TGGTATGCCAGCAACTATGAGCAACCCTCGGATTCCCCAGGCAAATGCACAGCAGTTTCCATTTCCTCCAAACTACGGAATAAGTCAGCA
ACCTGATCCAGGCTTTACTGGGGCTACGACTCCCCAGAGCCCACTTATGTCACCCCGAATGGCACATACACAGAGTCCCATGATGCAACA
GTCTCAGGCCAACCCAGCCTATCAGGCCCCCTCCGACATAAATGGATGGGCGCAGGGGAACATGGGCGGAAACAGCATGTTTTCCCAGCA
GTCCCCACCACACTTTGGGCAGCAAGCAAACACCAGCATGTACAGTAACAACATGAACATCAATGTGTCCATGGCGACCAACACAGGTGG
CATGAGCAGCATGAACCAGATGACAGGACAGATCAGCATGACCTCAGTGACCTCCGTGCCTACGTCAGGGCTGTCCTCCATGGGTCCCGA
GCAGGTTAATGATCCTGCTCTGAGGGGAGGCAACCTGTTCCCAAACCAGCTGCCTGGAATGGATATGATTAAGCAGGAGGGAGACACAAC
ACGGAAATATTGCTGACACTGCTGAAGCCAGTTGCTTCTTCAGCTGACCGGGCTCACTTGCTCAAAACACTTCCAGTCTGGAGAGCTGTG
TCTATTTGTTTCAACCCAACTGACCTGCCAGCCGGTTCTGCTAGAGCAGACAGGCCTGGCCCTGGTTCCCAGGGTGGCGTCCACTCGGCT
GTGGCAGGAGGAGCTGCCTCTTCTCTTGACAGTCTGAAGCTCGCATCCAGACAGTCGCTCAGTCTGTTCACTGCATTCACCTTAGTGCAA
CTTAGATCTCTCCTGCAAAAGTAAATGTTGACAGGCAAATTTCATACCCATGTCAGATTGAATGTATTTAAATGTATGTATTTAAGGAGA
ACCATGCTCTTGTTCTGTTCCTGTTCGGTTCCAGACACTGGTTTCTTGCTTTGTTTTCCCTGGCTAACAGTCTAGTGCAAAAGATTAAGA
TTTTATCTGGGGGAAAGAAAAGAATTTTTTAAAAAATTAAACTAAAGATGTTTTAAGCTAAAGCCTGAATTTGGGATGGAAGCAGGACAG
ACACCGTGGACAGCGCTGTATTTACAGACACACCCAGTGCGTGAAGACCAACAAAGTCACAGTCGTATCTCTAGAAAGCTCTAAAGACCA
TGTTGGAAAGAGTCTCCAGTTACTGAACAGATGAAAAGGAGCCTGTGAGAGGGCTGTTAACATTAGCAAATATTTTTTCCTTGTTTTTTC
TTTGTTAAAACCAAACTGGTTCACCTGAATCATGAATTGAGAAGAAATAATTTTCATTTCTAAATTAAGTCCCTTTTAGTTTGATCAGAC
AGCTTGAATCAGCATCTCTTCTTCCCTGTCAGCCTGACTCTTCCCTTCCCCTCTCTCATTCCCCATACTCCCTATTTTCATTCCTTTTTT
AAAAAATAATATAAGCTACAGAAACCAGGTAAGCCCTTTATTTCCTTAAATGTTTTGCCAGCCACTTACCAATTGCTAAGTATTGAATTT
CAGAAAAAAAAAATGCATTTACTGGCAAGGAGAAGAGCAAAGTTAAGGCTTGATACCAATCGAGCTAAGGATACCTGCTTTGGAAGCATG
TTTATTCTGTTCCCCAGCAACTCTGGCCTCCAAAATGGGAGAAAACGCCAGTGTGTTTAAATTGATAGCAGATATCACGACAGATTTAAC
CTCTGCCATGTGTTTTTTATTTTGTTTTTTAGCAGTGCTGACTAAGCCGAAGTTTTGTAAGGTACATAAAATCCAATTTATATGTAAACA
AGCAATAATTTAAGTTGAGAACTTATGTGTTTTAATTGTATAATTTTTGTGAGGTATACATATTGTGGAATTGACTCAAAAATGAGGTAC
TTCAGTATTAAATTAGATATCTTCATAGCAATGTCTCCTAAAGGTGTTTTGTAAAGGATATCAATGCCTTGATTAGACCTAATTTGTAGA
CTTAAGACTTTTTATTTTCTAAACCTTGTGATTCTGCTTATAAGTCATTTATCTAATCTATATGATATGCAGCCGCTGTAGGAACCAATT
CTTGATTTTTATATGTTTATATTCTTTCTTAATGAACCTTAGAAAGACTACATGTTACTAAGCAGGCCACTTTTATGGTTGTTTTTCTTG
CCCACTCTGGTAGGGGAAAAATCTTTTATTAATAGGTGTCAGTTTCAGACAACTCCAATACCAAGAAACTGATGACCTTTTTTGAGCTAT
TTCTCCTTAACCCCTAATACCTTTCTTACCTAAATTTCAGAATGATATCTTTTTGATGTCTAAAAAGCAAAGCATTTTATAATATCTCAT
TAGCCAGGCTTTTTAGGAACAGAGAAGTTTTTCCTTGAAATTTGATTGTTTGTTTATTTGTGGCAGGGTGAAAAATGTACAAACTACCCC
TATTTATACTTATATCTCTCTCTATATGTACGCATTATGGAAATATAGGAAGAGATATAGCCCAAAGATAGATGGTAAGTAGACAGTCTG
AAAATGTTGCTCCATACTAAAGAACCTTTCTGGAAATTTGCATTTCGCTACTTTTTTCCACTTGAGAGGGGTCTCAATACAGGGAGGTGG
CCAAGGAACAACACTTCTCAGTGGCCACCAGTTCATATATCCCCTCAAAAGGCTCTACTTTTCTCCACCAAACCATTGGGTTGCCCAACT
GTGATGGAAAAAACAAGCAGATGTTGGCCCAGAACTCCAGGACCTCCCCGTGGGCTGAGGCTCATGTGGCATACAATTCAGTGTGACCAG
TTTTAATGTTCAGAAATATGTGAATTAGAATGACTTTTAACTTCACACAGCACAAAAGAGAAATGGAGTTTAAACTGGATTTGTTTTGTT
TTGAGTTTCAAGTCCCTTTTCACTACAACACCGTCCAAAACTATCTACCTATCTCTTCTTTTTTATCCATCTGCCCGCTGTATTTTAATG
TCAATCCTAATTCAGACAAATCCGCAACTTCATGATACTGGTAATTTATAATAATTCGTGATCATTGCTGTTTTGAAGGAAAAGAGATGA
TAAATTCTCTTACGGTTTCAATCAGGTAATGGATTTTGTTTTACATCTAGTTAGGAGAAGAAAAGTAAGTGAAGGAATCCTCTGATCATA
TTGATCACTATAGAAGCAAAAGCCAAATCAGTTCCCTTCATTATCAGTATTTCTCATGCTGTACACAATAAATTTGTTAGACTGAGTACT
TGGTTTTTGTTTAATAGAACAAATAATCAGTGTTTCACTTATATTACTAAATGTGAAAAACATAATGTGAAAAGTATACATACATTAACT
TGGTTGTAAAACTCATTTTAAGTGTTCATGTAATGTGGTAAGTTTAAAAAGTGAAGTGAGCTGTTTTACTACAATGAATTCGTTTGACTC
AAAGATTAAAATGCCCCTCCCCCTATGTGTATCTCTTATGGCCTGTAATAATTGAAAGCAATGTTTTTGCAGTTTATATAATGCAATTTT
TAATCTGTGTTCAAAAATGGAGTTCATATGGGCTTAACACATGAAATGGGTGGCACAGATCCACTTGCAGAACCCAAAGATACACAATCA
GTTTTGAAATGCAACTTAAGCCATTAATTGTTGGTGTGAATTTAAAATTTTCTAGTGTTTGTATGGTGGTATGCTGCCTAAGAGCAAAGC
ATCCTCTGCACAAAAGAAAATTACTGTAGTGGCTTCGATTTTAATTAGAATTTTCTCCCTGGTGTTTCTTTATAGACTAAAGCAAAATCT
TTTAAGTTTCTTACTACAGGTAAAAGCTATGTGCAAGAACCTCAAAATGCTAAAATCTAGCATAATGCCTTAGATCTGTTTTTAAGTCTT
GTATATTCCTACATAGCTGTCCGATGTATTATATTTGTATAGTGAATTGTGTACAATTTTTGAATAAGTGCATCATCACTTAACCTTTAT
GTTGTTTGAATAGTGATGATGATACATTTCTTCAGACATTTAACTGTCATTTTTTTCCTTTGTCATTTGTGAGTTTTATTTGTACAGTTC
CTCATGAAGTTGCATCTGAGATGTGTGTATATGAAAAGATTATACAAGGGTAAAATTAAGCAATATATTAACTATGGTTCTTCAGGAGAA
AGCTTACAGTGTTTCAGGTTGTGATTTATTTTCAAAATGGAGTTGACTCTGAACATCACTTTGTTCACCTGCATTGATGTTTGTATTTCT
AGTGTGAGCAGTTTATGCAAAGGTAGATATATTCAGAGAAATTTTAAATACATTTATGCAAGTTAATATTGCTTTGCTGATGCTATTTGC
TTATTTGATGTTAAATAATGCTATTGTAAATAAAGAATTCTGTTGTTATTGCATCATTTAATAAATTTTAATGCCTTCGGGTTTTACATG

>41213_41213_2_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000396930_NCOA2_chr8_71057084_ENST00000452400_length(amino acids)=1713AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMG
NQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGP
SELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALG
IPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRL
QLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSG
MPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQS
PPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KAT6A-NCOA2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000265713	-	16	17	144_664	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000396930	-	17	18	144_664	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000406337	-	17	18	144_664	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000265713	-	16	17	312_664	1117.3333333333333	2005.0	RUNX1-1
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000396930	-	17	18	312_664	1117.3333333333333	2005.0	RUNX1-1
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000406337	-	17	18	312_664	1117.3333333333333	2005.0	RUNX1-1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000265713	-	16	17	1517_1741	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000396930	-	17	18	1517_1741	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000406337	-	17	18	1517_1741	1117.3333333333333	2005.0	PML
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000265713	-	16	17	1517_1642	1117.3333333333333	2005.0	RUNX1-2
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000396930	-	17	18	1517_1642	1117.3333333333333	2005.0	RUNX1-2
Hgene	KAT6A	chr8:41794774	chr8:71057084	ENST00000406337	-	17	18	1517_1642	1117.3333333333333	2005.0	RUNX1-2
Tgene	NCOA2	chr8:41794774	chr8:71057084	ENST00000452400		11	23	730_1121	868.3333333333334	1465.0	ARNTL

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KAT6A-NCOA2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KAT6A-NCOA2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source