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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KAT6A-SPPL2A (FusionGDB2 ID:41217)

Fusion Gene Summary for KAT6A-SPPL2A

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6A-SPPL2A
Fusion gene ID: 41217
HgeneTgene
Gene symbol

KAT6A

SPPL2A

Gene ID

7994

84888

Gene namelysine acetyltransferase 6Asignal peptide peptidase like 2A
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220IMP3|PSL2
Cytomap

8p11.21

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionsignal peptide peptidase-like 2AIMP-3SPP-like 2Aintramembrane cleaving proteaseintramembrane protease 3presenilin-like protein 2
Modification date2020031320200313
UniProtAcc

Q92794

Q8TCT8

Ensembl transtripts involved in fusion geneENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000559293, ENST00000261854, 
Fusion gene scores* DoF score26 X 32 X 13=1081611 X 9 X 7=693
# samples 4211
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/693*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT6A [Title/Abstract] AND SPPL2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAT6A(41832221)-SPPL2A(51041943), # samples:2
Anticipated loss of major functional domain due to fusion event.KAT6A-SPPL2A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-SPPL2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-SPPL2A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-SPPL2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358

TgeneSPPL2A

GO:0006509

membrane protein ectodomain proteolysis

16829951|17965014

TgeneSPPL2A

GO:0031293

membrane protein intracellular domain proteolysis

16829951|17557115

TgeneSPPL2A

GO:0033619

membrane protein proteolysis

2313285


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPPL2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EWKAT6Achr8

41832221

-SPPL2Achr15

51041943

-


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Fusion Gene ORF analysis for KAT6A-SPPL2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265713ENST00000559293KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
5CDS-intronENST00000396930ENST00000559293KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
5CDS-intronENST00000406337ENST00000559293KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
5CDS-intronENST00000485568ENST00000559293KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
Frame-shiftENST00000406337ENST00000261854KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
In-frameENST00000265713ENST00000261854KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
In-frameENST00000396930ENST00000261854KAT6Achr8

41832221

-SPPL2Achr15

51041943

-
In-frameENST00000485568ENST00000261854KAT6Achr8

41832221

-SPPL2Achr15

51041943

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265713KAT6Achr841832221-ENST00000261854SPPL2Achr1551041943-388218944123390992
ENST00000396930KAT6Achr841832221-ENST00000261854SPPL2Achr1551041943-401420265443522992
ENST00000485568KAT6Achr841832221-ENST00000261854SPPL2Achr1551041943-388218944123390992

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000261854KAT6Achr841832221-SPPL2Achr1551041943-0.0001604290.99983954
ENST00000396930ENST00000261854KAT6Achr841832221-SPPL2Achr1551041943-0.0001907520.9998093
ENST00000485568ENST00000261854KAT6Achr841832221-SPPL2Achr1551041943-0.0001604290.99983954

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Fusion Genomic Features for KAT6A-SPPL2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KAT6A-SPPL2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41832221/chr15:51041943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

SPPL2A

Q8TCT8

FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:23132852}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817371_3794942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918371_3794942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918371_3794942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-81795_1714942005.0DomainH15
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-91895_1714942005.0DomainH15
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-91895_1714942005.0DomainH15
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171_1444942005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-81752_1664942005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181_1444942005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-91852_1664942005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181_1444942005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-91852_1664942005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817206_2654942005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817259_3134942005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918206_2654942005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918259_3134942005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918206_2654942005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918259_3134942005.0Zinc fingerPHD-type 2
TgeneSPPL2Achr8:41832221chr15:51041943ENST0000026185401563_15122521.0DomainNote=PA
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015463_46522521.0MotifNote=PAL
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015495_49822521.0MotifNote=YXXo lysosomal targeting motif
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015194_22022521.0Topological domainCytoplasmic
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015242_24722521.0Topological domainLumenal
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015269_28522521.0Topological domainCytoplasmic
TgeneSPPL2Achr8:41832221chr15:51041943ENST0000026185401526_17222521.0Topological domainLumenal
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015307_31122521.0Topological domainLumenal
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015333_34022521.0Topological domainCytoplasmic
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015362_39922521.0Topological domainLumenal
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015421_43722521.0Topological domainCytoplasmic
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015459_46022521.0Topological domainLumenal
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015482_52022521.0Topological domainCytoplasmic
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015173_19322521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015221_24122521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015248_26822521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015286_30622521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015312_33222521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015341_36122521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015400_42022521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015438_45822521.0TransmembraneHelical
TgeneSPPL2Achr8:41832221chr15:51041943ENST00000261854015461_48122521.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171019_10264942005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171069_10784942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171147_11504942005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171221_12424942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171267_13024942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171411_14144942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171593_15974942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171643_17044942005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171897_19774942005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817788_8014942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817989_9954942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181019_10264942005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181069_10784942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181147_11504942005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181221_12424942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181267_13024942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181411_14144942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181593_15974942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181643_17044942005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181897_19774942005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918788_8014942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918989_9954942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181019_10264942005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181069_10784942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181147_11504942005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181221_12424942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181267_13024942005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181411_14144942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181593_15974942005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181643_17044942005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181897_19774942005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918788_8014942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918989_9954942005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817504_7784942005.0DomainMYST-type HAT
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918504_7784942005.0DomainMYST-type HAT
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918504_7784942005.0DomainMYST-type HAT
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171913_19484942005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817488_7784942005.0RegionNote=Catalytic
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817645_6494942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817654_6604942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181913_19484942005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918488_7784942005.0RegionNote=Catalytic
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918645_6494942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918654_6604942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181913_19484942005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918488_7784942005.0RegionNote=Catalytic
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918645_6494942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918654_6604942005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817537_5624942005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918537_5624942005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918537_5624942005.0Zinc fingerC2HC MYST-type


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Fusion Gene Sequence for KAT6A-SPPL2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41217_41217_1_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000265713_SPPL2A_chr15_51041943_ENST00000261854_length(transcript)=3882nt_BP=1894nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGCA
TAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTG
AGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAA
GGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTAC
TCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGAT
TTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGA
TCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGA
TCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGAT
AAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGC
ATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGA
TGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCT
TCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAA
GCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAA
GGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTC
ATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAG
GAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAA
GAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCA
ATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAA
CAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTA
CTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAA
ACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACT
GCAGACAGCCGCTCAGGAAGCAATCTTGCATGCGTCTGGAAATGGCACAACCAAGGACTACTGCATGCTTTATAACCCTTATTGGACAGC
TCTTCCAAGTACCCTAGAAAATGCAACTTCCATTAGTTTGATGAATCTGACTTCCACACCACTATGCAACCTTTCTGATATTCCTCCTGT
TGGCATAAAGAGCAAAGCAGTTGTGGTTCCATGGGGAAGCTGCCATTTTCTTGAAAAAGCCAGAATTGCACAGAAAGGAGGTGCTGAAGC
AATGTTAGTTGTCAATAACAGTGTCCTATTTCCTCCCTCAGGTAACAGATCTGAATTTCCTGATGTGAAAATACTGATTGCATTTATAAG
CTACAAAGACTTTAGAGATATGAACCAGACTCTAGGAGATAACATTACTGTGAAAATGTATTCTCCATCGTGGCCTAACTTTGATTATAC
TATGGTGGTTATTTTTGTAATTGCGGTGTTCACTGTGGCATTAGGTGGATACTGGAGTGGACTAGTTGAATTGGAAAACTTGAAAGCAGT
GACAACTGAAGATAGAGAAATGAGGAAAAAGAAGGAAGAATATTTAACTTTTAGTCCTCTTACAGTTGTAATATTTGTGGTCATCTGCTG
TGTTATGATGGTCTTACTTTATTTCTTCTACAAATGGTTGGTTTATGTTATGATAGCAATTTTCTGCATAGCATCAGCAATGAGTCTGTA
CAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCACGATTGCATGTCGTGGCAAAAACATGGAAGTGAGACTTATTTT
TCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCGAAATGAAGACAGGTGGGCTTGGATTTTACAGGATATCTTGGG
GATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTTCAAGTCATGTGTGATACTTCTAGGCCTTCTCCTCCTCTATGA
TGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTGAACTCGCAGCTGGACCTTTTGGAAATAATGA
AAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGTAATGAGTGTGTGCCTCATGCCTGTTTCAATATTGGGTTTTGG
AGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGATGTTCAGACTGGTTCTTCTTACATATACTATGTTTCGTCTAC
AGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCTATTTAGTACCTTG
CACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGATGATGGACCATTT
GGATTGTGCAACAAATGAAGAAAACCCTGTGATATCTGGTGAACAGATTGTCCAGCAATAATATTATGTGGAACTGCTATAATGTGTCAT
TGATTTTCTACAAATAGACTTCGACTTTTTAAATTGACTTTTGAATTGACAATCTGAAAGAGTCTTCAATGATATGCTTGCAAAAATATA
TTTTTATGAGCTGGTACTGACAGTTACATCATAAATAACTAAAACGCTTTGCTTTTAATGTTAAAGTTGTGCCTTCACATTAAATAAAAC
ATATGGTCTGTGTAGTTTCCGAGATGTACTATATACAGTATATTTTTCTAAAAAAAAATGCCTTGACCCACCCCTATACTTTTTTTTAAC
GAAATCTGTTTCTTTCAGCTCTGATGGTAGATACAAGTAGTTACTATTTCTGAATGGGTTTTACTGTAAAGAATTATGCAAATTGGCCAG
GCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAAC

>41217_41217_1_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000265713_SPPL2A_chr15_51041943_ENST00000261854_length(amino acids)=992AA_BP=494
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLT
STPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITV
KMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVM
IAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFK
SCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDV
QTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIV

--------------------------------------------------------------
>41217_41217_2_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000396930_SPPL2A_chr15_51041943_ENST00000261854_length(transcript)=4014nt_BP=2026nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGTGAG
CAGAGATTGCGGAGTACAGAATAGCCATCACCCACTCTGGCATAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGA
GTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTT
GGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTT
CCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTT
CACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGA
AGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAAC
AATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGG
AAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAA
AAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATT
GGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAA
AGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTG
TAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCC
ATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCG
AGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCG
TATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACG
GCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGG
CCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGG
CTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCC
TTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCAC
TTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGA
GAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGACAGCCGCTCAGGAAGCAATCTTGCATGCGTCTGGAAATGGCAC
AACCAAGGACTACTGCATGCTTTATAACCCTTATTGGACAGCTCTTCCAAGTACCCTAGAAAATGCAACTTCCATTAGTTTGATGAATCT
GACTTCCACACCACTATGCAACCTTTCTGATATTCCTCCTGTTGGCATAAAGAGCAAAGCAGTTGTGGTTCCATGGGGAAGCTGCCATTT
TCTTGAAAAAGCCAGAATTGCACAGAAAGGAGGTGCTGAAGCAATGTTAGTTGTCAATAACAGTGTCCTATTTCCTCCCTCAGGTAACAG
ATCTGAATTTCCTGATGTGAAAATACTGATTGCATTTATAAGCTACAAAGACTTTAGAGATATGAACCAGACTCTAGGAGATAACATTAC
TGTGAAAATGTATTCTCCATCGTGGCCTAACTTTGATTATACTATGGTGGTTATTTTTGTAATTGCGGTGTTCACTGTGGCATTAGGTGG
ATACTGGAGTGGACTAGTTGAATTGGAAAACTTGAAAGCAGTGACAACTGAAGATAGAGAAATGAGGAAAAAGAAGGAAGAATATTTAAC
TTTTAGTCCTCTTACAGTTGTAATATTTGTGGTCATCTGCTGTGTTATGATGGTCTTACTTTATTTCTTCTACAAATGGTTGGTTTATGT
TATGATAGCAATTTTCTGCATAGCATCAGCAATGAGTCTGTACAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCAC
GATTGCATGTCGTGGCAAAAACATGGAAGTGAGACTTATTTTTCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCG
AAATGAAGACAGGTGGGCTTGGATTTTACAGGATATCTTGGGGATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTT
CAAGTCATGTGTGATACTTCTAGGCCTTCTCCTCCTCTATGATGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAG
TATCATGGTTGAACTCGCAGCTGGACCTTTTGGAAATAATGAAAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGT
AATGAGTGTGTGCCTCATGCCTGTTTCAATATTGGGTTTTGGAGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGA
TGTTCAGACTGGTTCTTCTTACATATACTATGTTTCGTCTACAGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCT
GATGAAAAAGGGGCAACCTGCTCTCCTCTATTTAGTACCTTGCACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAA
AAAGTTCTGGAAAGGTAACAGCTATCAGATGATGGACCATTTGGATTGTGCAACAAATGAAGAAAACCCTGTGATATCTGGTGAACAGAT
TGTCCAGCAATAATATTATGTGGAACTGCTATAATGTGTCATTGATTTTCTACAAATAGACTTCGACTTTTTAAATTGACTTTTGAATTG
ACAATCTGAAAGAGTCTTCAATGATATGCTTGCAAAAATATATTTTTATGAGCTGGTACTGACAGTTACATCATAAATAACTAAAACGCT
TTGCTTTTAATGTTAAAGTTGTGCCTTCACATTAAATAAAACATATGGTCTGTGTAGTTTCCGAGATGTACTATATACAGTATATTTTTC
TAAAAAAAAATGCCTTGACCCACCCCTATACTTTTTTTTAACGAAATCTGTTTCTTTCAGCTCTGATGGTAGATACAAGTAGTTACTATT
TCTGAATGGGTTTTACTGTAAAGAATTATGCAAATTGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCG

>41217_41217_2_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000396930_SPPL2A_chr15_51041943_ENST00000261854_length(amino acids)=992AA_BP=494
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLT
STPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITV
KMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVM
IAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFK
SCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDV
QTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIV

--------------------------------------------------------------
>41217_41217_3_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000485568_SPPL2A_chr15_51041943_ENST00000261854_length(transcript)=3882nt_BP=1894nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGCA
TAAGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTG
AGAAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAA
GGAGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTAC
TCAGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGAT
TTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGA
TCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGA
TCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGAT
AAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGC
ATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGA
TGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCT
TCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAA
GCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAA
GGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTC
ATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAG
GAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAA
GAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCA
ATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAA
CAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTA
CTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAA
ACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACT
GCAGACAGCCGCTCAGGAAGCAATCTTGCATGCGTCTGGAAATGGCACAACCAAGGACTACTGCATGCTTTATAACCCTTATTGGACAGC
TCTTCCAAGTACCCTAGAAAATGCAACTTCCATTAGTTTGATGAATCTGACTTCCACACCACTATGCAACCTTTCTGATATTCCTCCTGT
TGGCATAAAGAGCAAAGCAGTTGTGGTTCCATGGGGAAGCTGCCATTTTCTTGAAAAAGCCAGAATTGCACAGAAAGGAGGTGCTGAAGC
AATGTTAGTTGTCAATAACAGTGTCCTATTTCCTCCCTCAGGTAACAGATCTGAATTTCCTGATGTGAAAATACTGATTGCATTTATAAG
CTACAAAGACTTTAGAGATATGAACCAGACTCTAGGAGATAACATTACTGTGAAAATGTATTCTCCATCGTGGCCTAACTTTGATTATAC
TATGGTGGTTATTTTTGTAATTGCGGTGTTCACTGTGGCATTAGGTGGATACTGGAGTGGACTAGTTGAATTGGAAAACTTGAAAGCAGT
GACAACTGAAGATAGAGAAATGAGGAAAAAGAAGGAAGAATATTTAACTTTTAGTCCTCTTACAGTTGTAATATTTGTGGTCATCTGCTG
TGTTATGATGGTCTTACTTTATTTCTTCTACAAATGGTTGGTTTATGTTATGATAGCAATTTTCTGCATAGCATCAGCAATGAGTCTGTA
CAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCACGATTGCATGTCGTGGCAAAAACATGGAAGTGAGACTTATTTT
TCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCGAAATGAAGACAGGTGGGCTTGGATTTTACAGGATATCTTGGG
GATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTTCAAGTCATGTGTGATACTTCTAGGCCTTCTCCTCCTCTATGA
TGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTGAACTCGCAGCTGGACCTTTTGGAAATAATGA
AAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGTAATGAGTGTGTGCCTCATGCCTGTTTCAATATTGGGTTTTGG
AGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGATGTTCAGACTGGTTCTTCTTACATATACTATGTTTCGTCTAC
AGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCTATTTAGTACCTTG
CACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGATGATGGACCATTT
GGATTGTGCAACAAATGAAGAAAACCCTGTGATATCTGGTGAACAGATTGTCCAGCAATAATATTATGTGGAACTGCTATAATGTGTCAT
TGATTTTCTACAAATAGACTTCGACTTTTTAAATTGACTTTTGAATTGACAATCTGAAAGAGTCTTCAATGATATGCTTGCAAAAATATA
TTTTTATGAGCTGGTACTGACAGTTACATCATAAATAACTAAAACGCTTTGCTTTTAATGTTAAAGTTGTGCCTTCACATTAAATAAAAC
ATATGGTCTGTGTAGTTTCCGAGATGTACTATATACAGTATATTTTTCTAAAAAAAAATGCCTTGACCCACCCCTATACTTTTTTTTAAC
GAAATCTGTTTCTTTCAGCTCTGATGGTAGATACAAGTAGTTACTATTTCTGAATGGGTTTTACTGTAAAGAATTATGCAAATTGGCCAG
GCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAAC

>41217_41217_3_KAT6A-SPPL2A_KAT6A_chr8_41832221_ENST00000485568_SPPL2A_chr15_51041943_ENST00000261854_length(amino acids)=992AA_BP=494
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLT
STPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITV
KMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVM
IAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFK
SCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDV
QTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KAT6A-SPPL2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817144_664494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171517_1741494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918144_664494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181517_1741494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918144_664494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181517_1741494.02005.0PML
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-817312_664494.02005.0RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-918312_664494.02005.0RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-918312_664494.02005.0RUNX1-1
HgeneKAT6Achr8:41832221chr15:51041943ENST00000265713-8171517_1642494.02005.0RUNX1-2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000396930-9181517_1642494.02005.0RUNX1-2
HgeneKAT6Achr8:41832221chr15:51041943ENST00000406337-9181517_1642494.02005.0RUNX1-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KAT6A-SPPL2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KAT6A-SPPL2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource