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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KAT7-F10 (FusionGDB2 ID:41249)

Fusion Gene Summary for KAT7-F10

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT7-F10
Fusion gene ID: 41249
HgeneTgene
Gene symbol

KAT7

F10

Gene ID

11143

83541

Gene namelysine acetyltransferase 7family with sequence similarity 110 member A
SynonymsHBO1|HBOA|MYST2|ZC2HC7C20orf55|F10|bA371L19.3
Cytomap

17q21.33

20p13

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1protein FAM110A
Modification date2020032720200313
UniProtAcc

O95251

P00742

Ensembl transtripts involved in fusion geneENST00000259021, ENST00000424009, 
ENST00000435742, ENST00000503935, 
ENST00000454930, ENST00000509773, 
ENST00000510819, ENST00000513980, 
ENST00000483537, ENST00000375551, 
ENST00000375559, ENST00000409306, 
Fusion gene scores* DoF score5 X 4 X 4=806 X 7 X 4=168
# samples 77
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT7 [Title/Abstract] AND F10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAT7(47875920)-F10(113792771), # samples:3
Anticipated loss of major functional domain due to fusion event.KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT7

GO:0006260

DNA replication

16387653

HgeneKAT7

GO:0018393

internal peptidyl-lysine acetylation

26221039

HgeneKAT7

GO:0031098

stress-activated protein kinase signaling cascade

21856198

HgeneKAT7

GO:0043966

histone H3 acetylation

16387653

HgeneKAT7

GO:0043981

histone H4-K5 acetylation

16387653

HgeneKAT7

GO:0043982

histone H4-K8 acetylation

16387653

HgeneKAT7

GO:0043983

histone H4-K12 acetylation

16387653

HgeneKAT7

GO:0043984

histone H4-K16 acetylation

16387653

HgeneKAT7

GO:1900182

positive regulation of protein localization to nucleus

24739512


check buttonFusion gene breakpoints across KAT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across F10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-A71O-01AKAT7chr17

47875920

-F10chr13

113792771

+
ChimerDB4SARCTCGA-SI-A71O-01AKAT7chr17

47875920

+F10chr13

113792771

+
ChimerDB4SARCTCGA-SI-A71O-06AKAT7chr17

47875920

-F10chr13

113792771

+
ChimerDB4SARCTCGA-SI-A71OKAT7chr17

47875920

+F10chr13

113792770

+


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Fusion Gene ORF analysis for KAT7-F10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000259021ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
5CDS-intronENST00000259021ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
5CDS-intronENST00000424009ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
5CDS-intronENST00000424009ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
5CDS-intronENST00000435742ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
5CDS-intronENST00000435742ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
5CDS-intronENST00000503935ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
5CDS-intronENST00000503935ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000259021ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000259021ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000259021ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000259021ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000259021ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000259021ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000424009ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000424009ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000424009ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000424009ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000424009ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000424009ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000435742ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000435742ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000435742ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000435742ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000435742ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000435742ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000503935ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000503935ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000503935ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000503935ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
Frame-shiftENST00000503935ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
Frame-shiftENST00000503935ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000454930ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000454930ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000454930ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000454930ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000454930ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000454930ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000509773ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000509773ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000509773ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000509773ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000509773ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000509773ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000510819ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000510819ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000510819ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000510819ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000510819ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000510819ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000513980ENST00000375551KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000513980ENST00000375551KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000513980ENST00000375559KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000513980ENST00000375559KAT7chr17

47875920

+F10chr13

113792770

+
intron-3CDSENST00000513980ENST00000409306KAT7chr17

47875920

+F10chr13

113792771

+
intron-3CDSENST00000513980ENST00000409306KAT7chr17

47875920

+F10chr13

113792770

+
intron-intronENST00000454930ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
intron-intronENST00000454930ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
intron-intronENST00000509773ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
intron-intronENST00000509773ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
intron-intronENST00000510819ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
intron-intronENST00000510819ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+
intron-intronENST00000513980ENST00000483537KAT7chr17

47875920

+F10chr13

113792771

+
intron-intronENST00000513980ENST00000483537KAT7chr17

47875920

+F10chr13

113792770

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KAT7-F10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KAT7chr1747875920+F10chr13113792770+3.94E-081
KAT7chr1747875920+F10chr13113792770+3.94E-081
KAT7chr1747875920+F10chr13113792770+3.94E-081
KAT7chr1747875920+F10chr13113792770+3.94E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KAT7-F10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47875920/:113792771)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT7

O95251

F10

P00742

FUNCTION: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KAT7-F10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KAT7-F10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KAT7-F10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KAT7-F10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource