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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KATNAL2-MYO5B (FusionGDB2 ID:41269) |
Fusion Gene Summary for KATNAL2-MYO5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KATNAL2-MYO5B | Fusion gene ID: 41269 | Hgene | Tgene | Gene symbol | KATNAL2 | MYO5B | Gene ID | 83473 | 4645 |
| Gene name | katanin catalytic subunit A1 like 2 | myosin VB | |
| Synonyms | - | - | |
| Cytomap | 18q21.1 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | katanin p60 ATPase-containing subunit A-like 2katanin catalytic subunit A like 2katanin p60 subunit A like 2p60 katanin-like 2 | unconventional myosin-VbMYO5B variant proteinmyosin-Vb | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9ULV0 | |
| Ensembl transtripts involved in fusion gene | ENST00000356157, ENST00000592005, ENST00000245121, | ENST00000324581, ENST00000587895, ENST00000592688, ENST00000285039, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 11 X 10 X 7=770 |
| # samples | 4 | 14 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KATNAL2 [Title/Abstract] AND MYO5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KATNAL2(44526886)-MYO5B(47581748), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across KATNAL2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MYO5B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A8-A09D | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
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Fusion Gene ORF analysis for KATNAL2-MYO5B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000356157 | ENST00000324581 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5CDS-intron | ENST00000356157 | ENST00000587895 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5CDS-intron | ENST00000356157 | ENST00000592688 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5CDS-intron | ENST00000592005 | ENST00000324581 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5CDS-intron | ENST00000592005 | ENST00000587895 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5CDS-intron | ENST00000592005 | ENST00000592688 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5UTR-3CDS | ENST00000245121 | ENST00000285039 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5UTR-intron | ENST00000245121 | ENST00000324581 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5UTR-intron | ENST00000245121 | ENST00000587895 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| 5UTR-intron | ENST00000245121 | ENST00000592688 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| In-frame | ENST00000356157 | ENST00000285039 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| In-frame | ENST00000592005 | ENST00000285039 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000592005 | KATNAL2 | chr18 | 44526886 | + | ENST00000285039 | MYO5B | chr18 | 47581748 | - | 9902 | 724 | 595 | 6243 | 1882 |
| ENST00000356157 | KATNAL2 | chr18 | 44526886 | + | ENST00000285039 | MYO5B | chr18 | 47581748 | - | 9247 | 69 | 15 | 5588 | 1857 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000592005 | ENST00000285039 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - | 0.001087438 | 0.9989126 |
| ENST00000356157 | ENST00000285039 | KATNAL2 | chr18 | 44526886 | + | MYO5B | chr18 | 47581748 | - | 0.000645142 | 0.9993549 |
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Fusion Genomic Features for KATNAL2-MYO5B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KATNAL2-MYO5B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:44526886/chr18:47581748) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MYO5B |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 1341_1471 | 9 | 1849.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 899_1266 | 9 | 1849.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 801_916 | 9 | 1849.0 | Compositional bias | Note=Arg-rich | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 1526_1803 | 9 | 1849.0 | Domain | Dilute | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 69_761 | 9 | 1849.0 | Domain | Myosin motor | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 769_798 | 9 | 1849.0 | Domain | IQ 1 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 792_821 | 9 | 1849.0 | Domain | IQ 2 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 817_848 | 9 | 1849.0 | Domain | IQ 3 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 840_869 | 9 | 1849.0 | Domain | IQ 4 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 865_896 | 9 | 1849.0 | Domain | IQ 5 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 888_917 | 9 | 1849.0 | Domain | IQ 6 | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 8_60 | 9 | 1849.0 | Domain | Myosin N-terminal SH3-like | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 163_170 | 9 | 1849.0 | Nucleotide binding | ATP | |
| Tgene | MYO5B | chr18:44526886 | chr18:47581748 | ENST00000285039 | 0 | 40 | 640_662 | 9 | 1849.0 | Region | Actin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KATNAL2 | chr18:44526886 | chr18:47581748 | ENST00000245121 | + | 1 | 15 | 25_57 | 0 | 467.0 | Domain | LisH |
| Hgene | KATNAL2 | chr18:44526886 | chr18:47581748 | ENST00000356157 | + | 1 | 16 | 25_57 | 17 | 539.0 | Domain | LisH |
| Hgene | KATNAL2 | chr18:44526886 | chr18:47581748 | ENST00000245121 | + | 1 | 15 | 294_301 | 0 | 467.0 | Nucleotide binding | ATP |
| Hgene | KATNAL2 | chr18:44526886 | chr18:47581748 | ENST00000356157 | + | 1 | 16 | 294_301 | 17 | 539.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for KATNAL2-MYO5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >41269_41269_1_KATNAL2-MYO5B_KATNAL2_chr18_44526886_ENST00000356157_MYO5B_chr18_47581748_ENST00000285039_length(transcript)=9247nt_BP=69nt GTCCTAGCACAGTGTCTGATGGAGCTTTCCTACCAGACCCTGAAATTCACGCATCAGGCGCGGGAAGCGTGCACAAGGGTCTGGATCCCT GACCCTGATGAGGTATGGCGCTCAGCTGAGTTAACCAAGGACTACAAAGAAGGAGACAAGAGCCTACAGCTCAGACTGGAGGATGAAACG ATTCTGGAATACCCAATTGATGTACAACGCAACCAGCTGCCCTTCTTACGGAATCCAGATATCTTGGTGGGAGAAAATGACCTGACTGCC CTTAGCTATCTTCATGAGCCTGCAGTTTTGCATAATTTGAAGGTCCGTTTCCTGGAGTCCAACCATATCTACACTTACTGTGGTATCGTA CTTGTTGCCATTAATCCTTATGAACAGTTGCCAATCTATGGACAAGATGTCATCTATACCTACAGTGGCCAAAACATGGGAGACATGGAC CCCCACATCTTTGCTGTGGCAGAAGAAGCCTACAAGCAGATGGCCAGAGATGAGAAGAATCAGTCCATCATAGTCAGTGGGGAGTCTGGA GCCGGGAAGACGGTATCAGCCAAGTATGCCATGCGCTATTTCGCCACCGTTGGTGGCTCGGCCAGTGAAACCAACATCGAAGAGAAGGTG CTGGCATCCAGTCCCATCATGGAGGCCATTGGAAATGCCAAGACCACCCGCAATGACAACAGCAGCCGTTTTGGCAAGTACATCCAGATT GGCTTTGACAAAAGGTACCACATCATCGGGGCCAACATGAGGACTTACCTCTTGGAGAAGTCCAGAGTGGTCTTCCAGGCAGATGATGAG AGGAATTACCACATCTTTTACCAGCTCTGTGCTGCTGCCGGTCTTCCAGAATTTAAAGAGCTTGCACTAACAAGTGCAGAGGACTTTTTC TATACATCACAGGGAGGAGACACTTCCATCGAGGGTGTGGACGATGCTGAGGACTTTGAGAAGACTCGACAAGCCTTCACACTCCTCGGA GTGAAAGAGTCCCATCAGATGAGCATTTTTAAGATAATTGCTTCTATCTTGCACCTTGGAAGTGTGGCGATTCAGGCTGAGCGTGATGGT GATTCCTGTAGTATATCACCCCAGGATGTATACCTAAGCAACTTCTGCCGACTGCTAGGGGTGGAGCACAGTCAGATGGAGCACTGGCTG TGTCATCGCAAGCTGGTCACCACCTCGGAGACCTACGTCAAGACCATGTCCCTGCAGCAGGTGATCAATGCGCGCAACGCCCTGGCGAAG CACATCTATGCCCAGTTGTTCGGCTGGATTGTGGAGCACATCAACAAGGCCCTGCACACCTCCCTCAAGCAGCACTCCTTCATCGGGGTC CTGGACATCTATGGGTTTGAGACATTTGAGGTAAACAGCTTTGAGCAGTTCTGTATCAACTATGCAAATGAAAAGCTCCAGCAGCAGTTC AACTCGCATGTTTTCAAACTGGAGCAAGAAGAATACATGAAGGAACAGATCCCTTGGACCCTGATTGATTTTTATGATAACCAACCTTGT ATCGACCTCATTGAAGCCAAGCTGGGTATCTTGGACCTGTTGGATGAAGAATGTAAGGTCCCCAAAGGAACTGACCAGAACTGGGCTCAG AAGCTCTATGACCGGCACTCCAGCAGCCAGCACTTCCAGAAGCCCCGCATGTCCAACACGGCCTTCATCATCGTCCACTTTGCAGACAAG GTGGAGTACCTCTCTGATGGTTTTCTGGAGAAAAACAGAGACACGGTGTATGAAGAGCAGATCAATATCCTGAAGGCCAGCAAGTTCCCA CTAGTGGCTGACTTGTTTCATGATGACAAGGACCCTGTTCCTGCCACCACCCCTGGGAAGGGGTCATCTTCGAAGATCAGCGTCCGTTCT GCCAGACCCCCCATGAAAGTCTCCAACAAGGAGCACAAGAAAACCGTTGGCCACCAGTTCCGTACCTCCCTGCATCTGCTCATGGAGACC CTGAATGCCACGACACCTCACTATGTCCGCTGCATCAAGCCCAACGATGAGAAGCTCCCCTTTCACTTTGACCCAAAGAGAGCAGTGCAG CAACTCAGAGCCTGCGGGGTGTTGGAGACGATTCGAATCAGTGCAGCTGGCTACCCATCCAGGTGGGCCTACCATGACTTTTTCAACCGG TATCGGGTGCTGGTCAAGAAGAGAGAGCTCGCCAACACAGACAAAAAGGCCATCTGCAGGTCTGTCCTGGAGAACCTCATCAAGGACCCC GACAAGTTCCAGTTTGGCCGCACCAAGATCTTCTTTCGAGCAGGCCAGGTGGCCTACCTGGAGAAGCTGCGGGCTGACAAGTTCCGGACA GCCACCATCATGATCCAGAAAACTGTCCGGGGATGGCTGCAGAAGGTGAAATATCACAGGCTGAAGGGGGCTACCTTAACCCTGCAGAGG TACTGCCGGGGACACCTGGCCCGCAGGCTGGCTGAGCACCTGCGGAGGATCAGAGCGGCTGTGGTGCTCCAGAAACATTACCGCATGCAG AGGGCCCGCCAGGCCTACCAGAGGGTCCGCAGAGCTGCCGTTGTTATCCAGGCCTTCACCCGGGCCATGTTTGTGCGGAGAACCTACCGC CAGGTCCTCATGGAGCACAAGGCCACCACCATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAGGCACTTCCAGCGGCTGCGGGATGCA GCCATTGTCATCCAGTGTGCCTTCCGGATGCTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGATTGAGGCCCGCTCAGCAGAGCATCTG AAACGTCTCAACGTGGGCATGGAGAACAAGGTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAACAAAGAGTTCAAGACACTTTCAGAG CAGTTGTCCGTGACCACCTCAACATACACCATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCACTACCAGCAGAGCCCAGGTGAGGAC ACCAGCCTCAGGCTGCAGGAGGAGGTGGAGAGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGAGCGCAAGATCTTGGAGGACGCCCAC AGCAGGGAGAAAGATGAGCTGAGGAAGCGAGTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAAAGATGAGAAAGAACAGCTCAACAAC CAAATCCTGTGCCAGTCTAAAGATGAATTTGCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAAAGAACTGGAGGAGGAGCGATCCCGG TACCAGAACCTTGTGAAGGAATATTCACAGTTGGAGCAGAGATACGACAACCTTCGGGATGAAATGACCATCATAAAGCAAACTCCAGGT CATAGGCGGAACCCATCAAACCAAAGTAGCTTAGAATCTGACTCCAATTACCCCTCCATCTCCACATCTGAGATCGGAGACACTGAGGAT GCCCTCCAGCAGGTGGAGGAAATTGGCCTGGAGAAGGCAGCCATGGACATGACGGTCTTCCTGAAGCTGCAGAAGAGAGTACGGGAGCTG GAGCAGGAGAGGAAAAAGCTGCAAGTGCAGCTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGTCCAGGCGGAACCACCACAGACTGAC ATAGATTTGGACCCGAATGCAGATCTGGCCTACAATAGTCTGAAGAGGCAAGAGCTGGAGTCAGAGAACAAAAAGCTGAAGAATGACCTG AATGAGCTGAGGAAAGCCGTGGCCGACCAAGCCACGCAGAATAACTCCAGCCACGGCTCCCCAGATAGCTACAGCCTCCTGCTGAACCAG CTCAAGCTGGCCCACGAGGAGCTCGAGGTGCGCAAGGAGGAGGTGCTCATCCTCAGGACCCAGATCGTGAGCGCCGACCAGCGGCGACTC GCCGGCAGGAACGCGGAGCCGAACATTAATGCCAGATCAAGTTGGCCTAACAGTGAAAAGCATGTTGACCAGGAGGATGCCATTGAGGCC TATCACGGGGTCTGCCAGACAAACAGCAAGACTGAGGATTGGGGATATTTAAATGAAGATGGAGAACTCGGCTTGGCCTACCAAGGCCTA AAGCAAGTTGCCAGGCTGCTGGAGGCTCAGCTGCAGGCCCAGAGCCTGGAGCATGAGGAGGAGGTGGAGCATCTCAAGGCTCAGCTCGAG GCCCTGAAGGAGGAGATGGACAAACAGCAGCAGACCTTCTGCCAGACGCTACTGCTCTCCCCAGAGGCCCAGGTGGAATTCGGCGTTCAG CAGGAAATATCCCGGCTGACCAACGAGAATCTGGACCTTAAAGAACTGGTAGAAAAGCTGGAAAAGAATGAGAGGAAGCTCAAAAAGCAA CTGAAGATTTACATGAAGAAAGCCCAGGACCTAGAAGCTGCCCAGGCATTGGCCCAGAGTGAGAGGAAGCGCCATGAGCTCAACAGGCAG GTCACGGTCCAGCGGAAAGAGAAGGATTTCCAGGGCATGCTGGAGTACCACAAAGAGGACGAGGCCCTCCTCATCCGGAACCTGGTGACA GACTTGAAGCCCCAGATGCTGTCGGGCACAGTGCCCTGTCTCCCCGCCTACATCCTCTACATGTGCATCCGGCACGCGGACTACACCAAC GACGATCTCAAGGTGCACTCCCTGCTGACCTCCACCATCAACGGCATTAAGAAAGTCCTGAAAAAGCACAATGATGACTTTGAGATGACG TCATTCTGGTTATCCAACACCTGCCGCCTTCTTCACTGTCTGAAGCAGTACAGCGGGGATGAGGGCTTCATGACTCAGAACACTGCAAAG CAGAATGAACACTGTCTTAAGAATTTTGACCTCACCGAATACCGTCAGGTGCTGAGTGACCTTTCCATTCAGATCTACCAGCAGCTCATT AAAATTGCCGAGGGCGTGTTACAGCCGATGATAGTTTCTGCCATGTTGGAAAATGAGAGCATTCAGGGTCTATCTGGTGTGAAGCCCACC GGCTACCGGAAGCGCTCCTCCAGCATGGCAGATGGGGATAACTCATACTGCCTGGAAGCTATCATCCGCCAGATGAATGCCTTTCATACA GTCATGTGTGACCAGGGCTTGGACCCTGAGATCATCCTGCAGGTATTCAAACAGCTCTTCTACATGATCAACGCAGTGACTCTTAACAAC CTGCTCTTGCGGAAGGACGTCTGCTCTTGGAGCACAGGCATGCAACTCAGGTACAATATAAGTCAGCTTGAGGAGTGGCTTCGGGGAAGA AACCTTCACCAGAGTGGAGCAGTTCAGACCATGGAACCTCTGATCCAAGCAGCCCAGCTCCTGCAATTAAAGAAGAAAACCCAGGAGGAC GCAGAGGCTATCTGCTCCCTGTGTACCTCCCTCAGCACCCAGCAGATTGTCAAAATTTTAAACCTTTATACTCCCCTGAATGAATTTGAA GAACGGGTAACAGTGGCCTTTATACGAACAATCCAGGCACAACTACAAGAGCGGAATGACCCTCAGCAACTGCTATTAGATGCCAAGCAC ATGTTTCCTGTTTTGTTTCCATTTAATCCATCTTCTCTAACCATGGACTCAATCCACATCCCAGCGTGTCTCAATCTGGAATTCCTCAAT GAAGTCTGAAGATGCATGTTTCCAGCATTAGTTTGATTCCCAATGTGAGCAAGAAGGAAGTATATACAGTAAAGTAAATTCAAGGATCTG TTAAATCTGGTAAAAGTAGATCAAATCAGAGATTGACAGCCTGTGGAGGGTGCTGAACTATACAGAATTAGACACAACTATGTCATTATT TTTTGTACCTACTGCTCAGAATAAAAACACTTGAAATATGGAAGATTTTAAGTTTGATTTCAGTCCAACACATATACATAATTTATAGAC ACCAAGCAGTCCCCATAGACATATAAAAGGTGTCAATTCTATAAAACGAAGCTGCCTAGTTTTGATCTTTGCATAGAACTAGAGAATGTC CAAATTAAAATACCAAATATATATAAGTCACATAAATTGCCTTCAAAGGGCTTTAACAAATAATGGTACTAATAACCATGATAATGGCAT ATACTGACATTTCCCAAAGTTTGCAAACCATAGGTGTGGTTGAGTTTGTGGTGAGATGTTTTAAGAACAAAAATATGGGGATGAGACTTC TGAGAAATATTCCCAAAATATTTTTTAATGGCTGATTATACACAGACAGTGGTGTAACTGACCTCCAGACCAGACATTTTGAGTACTGGT TTCTGAAGCAAAATTAGAAGTGCCAGTCCTCAGTGTGCTCAAACGCTTTTGTGTTATCTTGATTTAATGGAAGAGATTATTAAAATGCTG CTATCCCAAACTCCAAGTGAGAAAGATGGAAAAATATTTTGTTTCTGATGCTAGTCCATACACTTTCCAAGTCCCACAAAACTTTCACAA AAATGTATATAAGCTAAATATTAGAAACGGATAACAAACTTGTTTTATTTATAGATGTAAAAACCAAACAAGTCAATATGAAAGCTTTTA ATCTCTTAATACCATTAAGCTTCCAGTAAGAGCATCACATAATGCTCTACTGTTCCAGAAACCAAATAGTAAAACAAACTAAAGTTCGCA CATCAGATCATCTGAAAAACCTTCAAAAATAATCAGTTCAGGGATATTATACAAAAGTTTGGGTTTTTTTTTTTTAAGAGAATAAAATGG CTTAGGTCAACTTTCCCTTTTCAGGTTATTTTCAACGTTTTTCAAATTTAGCACACAAAAAATTGTAAATATCTCTCCCACAAAATAAGG ATTTTAAAAAAGTAATTCAGTAATATAACAGGCTTAGATGTTTGCTGCTCTTAGAATTTTTTTTAACTTGTTTTTGGTTTCTTCAAAAGC AAGCATTCAATTGGAAACCCATATTCTTTCCACACTTTTTTTTACTGTCTTTTCTGTATTTCTTGATAGCAGTATGCTGTTCCCATAAGA AAAAAATGGTATTTGCAAATCATGGAAGAACAGCCTCTGTATTACATTGAGAAAATAAGATTTATCCATGAATTGGAAGTAGAACAGCCT GCCTTCACCCTCTTTTACTCAACCACCCAACTTAAAAGGCTCTTGGAAACACAGCACACTCCACGCTACCTTCTGCACTGTGCCCTTAGA GCACAGCTTCCTCAGTTGTTCTCTGCATCTCCTGGGGCTTAGGCCAGTCTTAGCCTGGGTTAAGGCTGCTGACATTGTGTTCCAATCAGT TGTCATGGGCATTATCCCCTCTACATCCACATTAAACATGCCGGCTTCTCTTGGGCATCGGCAGAGCTGTGCCTTTTTCTTTCAGTTACA GTTACATAATCACTGACGTCCATGACACTTACCCATGGATCCATGTGCTGACTTCATTTAGAAGGCCAATCTAAAACAACTGGGTTTGTG GCTACCTCTTTAAAGTTGTTTGTGAAGGATAATTTGTTTTTTAATGCACTTTAGTTTGAAAGTGAGTCTCTTATGTAAGGACCATCCTTA AAAGACCAAAAATGCCTTGTTAGAGTGTTAAGGAGTTTTGACATGCAGTGGTTCCACAAACACAGTGGCTTACTATCCTTATACACTGTC TTATACCATCATTCTCTCCATCTCTCTTGGTCACTACTCTCTGCTGTCACTGGTTAATCACTAGGTGCCAAGAGCTTACTGAATAAAAGC TTGGCAATTAGAATAAATGGGGAGGGAAGGACCTTATGAATAGTCCATTTAGCCTAAGAAATGGCAGATTTAGTTCTTCTCTTCCAAAAG ATAAAGGTATATCCTGGAATTGTACTTAAAACTTACAGATGACTAACAAATATATACTTTATATGTAGTTAATATTTAGATCTGTCTTAT TTAATACTTGGAGGCTAGAAGAAGCATCTTTAGGGGAACTATATAATCTTTTGTTAGCATTTTCTCTGCATTTTAAAAAATCATTTCAAT TCAAACATTTATCAGTGTCATGAAATCAGTAATGACTCTTTAACAATTCAGGTTTGAACTCTGCATTAGATGTCTCTTTAATTTTTTAAT ATTTAAAATTTAGTTGACATTTTTTTCACCAGGTGCCTTTAGCGGTTACTAAGATAACTGACATCAGTTGTTTCTCTGAAATAAGTGTTG CTGTGGGAATAATTTTAATGTTCAAGGTGATATCATGGGGGAGTTTTGTCTTTTAAAACATTAGAAGCATTTTAAATATTAAGAATCAAA TATTTATAGATCAAAACTTGTGTTTTAAGTATTATACGGGACCTGTTTACTTATAGTAAATGTGAATGTACACATGAGTTGTTGCTGAAG CTGACAAGCATATTACATACATGCATTTTCCCTGTGCCCTCATAGTTGCAGTTAGAGTTCCAGTACCTGTAGGCTCACCTGGGAGGCAGA TTAGACCCAAAGGTAGATGTTTTTCCCCTTTCCATGAAGCATGTCAGTGGGAGTTGCTTCCTTTGATTTCCCTAGTACTAAATTTTAAGG CTTTTGTAAAAACAAAACAAAACTAGGAGCTTGGAACAGTTAAAAATCAACACTGCTACCATCAATTCATCAAATATTTACTTAGAGCTT TCATACATTAAGATTCCAGTAACCAATAAATTAGAATTCATTTCTTCTGCATAAAGTAAATTTTCATACACTTGACCTACTAAGACAGCA AGGGTGTCCTAAATTGAGGCATTTGTATAATGCCTGCATAACTAAATGGTCACTAAAATGGGACAGCATGGGGCAAGACCTTGTAGTTCT TCACAGAATATTTGTGGTCAGTTTCTCCAATTAATTTGCTGCATGAGCCAAATAACCATAATTCACTTTTTATACCCACTGGTGCCATAA TTAGAGAATTAGAGGGTGTAGACAGAGGTTAATGCCAATGAGAAACACAGGACAGGGTTTTTTTTATTATAAAGGTCATTAGATACAAAA GATTGTTTTTCAAAAAATTTCTAATTCTAACAAAGGGGATCAATCAGAAATGAAACTAAGCTACTTTCTAAAGTGACACTGTATCAGAAT AATCCAGATTTGAATATAACATTTTGCCACCAACTGACATTTAGATGAAGGACTGCCTCTCTGAAAGAGTTCAGATCATATTCAGGGGTG AATCCAACACCATGGAAGAAAGACTACTGATGAAAATATTTTCCCACTTTGCACAAATCTGTAAACTACACCTTTGTTTATAGAAAAATG >41269_41269_1_KATNAL2-MYO5B_KATNAL2_chr18_44526886_ENST00000356157_MYO5B_chr18_47581748_ENST00000285039_length(amino acids)=1857AA_BP=18 MMELSYQTLKFTHQAREACTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLH EPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTV SAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHI FYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSI SPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYG FETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDR HSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPM KVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLV KKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGH LARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQ CAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRL QEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLV KEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERK KLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAH EELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVAR LLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYM KKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKV HSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEG VLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRK DVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTV -------------------------------------------------------------- >41269_41269_2_KATNAL2-MYO5B_KATNAL2_chr18_44526886_ENST00000592005_MYO5B_chr18_47581748_ENST00000285039_length(transcript)=9902nt_BP=724nt GCCGGGCCCGTCACGTGAACGGCGCGGGAGCTCCGCCTCCGACGCGCCGAAGCCCCGCCCCTAGCGGTGCCCCCTGCCCACCCGCGCGAC CGCCTTCCGCCCGCGCCTTCAGTCCGCGCGGCGACAGCGCCCGCCCGCGCCTGCCCCGGCGTGCTGCCCCGCGGCTTGGCCCCGCTCGGC CCCAGGTCGTGCCTTCCCTCCCCGGCGGAGGCCCCTGCGGACTGCCTAGAGCTGGGTCGCAACTGAGGCGTTATCCGCGGGCCTGGCCTC GGGAAGTGGCGGGGAGGAAGAAGAGGCGGCCGGGACGCGTGACAGGAGCATTCGGGAAGATTCTTACGGTGCCCTTCACGCGGTGCCTAT GGACGGAGAAAGCCGCCGCAAATAAAACCATCCCCCAGAGTAGTTGTGGCGGAATAATCTAAATATGGGTGTTGGATTGAGGAAACTTGA ATATTTTTGTATCCTGAAGGGAGAAATGGATGAAGAAGAAATGGATGAAGAAGACCGAAGATAATGATGAAGGGATAATTTGGAATAGGA TTCACAGCAAGAGAGACAGAAGGGAAAGACATTGAAGAAACAGACTAGTTAACACATGAAAAAAATAGAGCAGAGGAAAACACGTCCATG TTTTTCCACGTCTAATGAGAACAGGGTCCTAGCACAGTGTCTGATGGAGCTTTCCTACCAGACCCTGAAATTCACGCATCAGGCGCGGGA AGCGTGCACAAGGGTCTGGATCCCTGACCCTGATGAGGTATGGCGCTCAGCTGAGTTAACCAAGGACTACAAAGAAGGAGACAAGAGCCT ACAGCTCAGACTGGAGGATGAAACGATTCTGGAATACCCAATTGATGTACAACGCAACCAGCTGCCCTTCTTACGGAATCCAGATATCTT GGTGGGAGAAAATGACCTGACTGCCCTTAGCTATCTTCATGAGCCTGCAGTTTTGCATAATTTGAAGGTCCGTTTCCTGGAGTCCAACCA TATCTACACTTACTGTGGTATCGTACTTGTTGCCATTAATCCTTATGAACAGTTGCCAATCTATGGACAAGATGTCATCTATACCTACAG TGGCCAAAACATGGGAGACATGGACCCCCACATCTTTGCTGTGGCAGAAGAAGCCTACAAGCAGATGGCCAGAGATGAGAAGAATCAGTC CATCATAGTCAGTGGGGAGTCTGGAGCCGGGAAGACGGTATCAGCCAAGTATGCCATGCGCTATTTCGCCACCGTTGGTGGCTCGGCCAG TGAAACCAACATCGAAGAGAAGGTGCTGGCATCCAGTCCCATCATGGAGGCCATTGGAAATGCCAAGACCACCCGCAATGACAACAGCAG CCGTTTTGGCAAGTACATCCAGATTGGCTTTGACAAAAGGTACCACATCATCGGGGCCAACATGAGGACTTACCTCTTGGAGAAGTCCAG AGTGGTCTTCCAGGCAGATGATGAGAGGAATTACCACATCTTTTACCAGCTCTGTGCTGCTGCCGGTCTTCCAGAATTTAAAGAGCTTGC ACTAACAAGTGCAGAGGACTTTTTCTATACATCACAGGGAGGAGACACTTCCATCGAGGGTGTGGACGATGCTGAGGACTTTGAGAAGAC TCGACAAGCCTTCACACTCCTCGGAGTGAAAGAGTCCCATCAGATGAGCATTTTTAAGATAATTGCTTCTATCTTGCACCTTGGAAGTGT GGCGATTCAGGCTGAGCGTGATGGTGATTCCTGTAGTATATCACCCCAGGATGTATACCTAAGCAACTTCTGCCGACTGCTAGGGGTGGA GCACAGTCAGATGGAGCACTGGCTGTGTCATCGCAAGCTGGTCACCACCTCGGAGACCTACGTCAAGACCATGTCCCTGCAGCAGGTGAT CAATGCGCGCAACGCCCTGGCGAAGCACATCTATGCCCAGTTGTTCGGCTGGATTGTGGAGCACATCAACAAGGCCCTGCACACCTCCCT CAAGCAGCACTCCTTCATCGGGGTCCTGGACATCTATGGGTTTGAGACATTTGAGGTAAACAGCTTTGAGCAGTTCTGTATCAACTATGC AAATGAAAAGCTCCAGCAGCAGTTCAACTCGCATGTTTTCAAACTGGAGCAAGAAGAATACATGAAGGAACAGATCCCTTGGACCCTGAT TGATTTTTATGATAACCAACCTTGTATCGACCTCATTGAAGCCAAGCTGGGTATCTTGGACCTGTTGGATGAAGAATGTAAGGTCCCCAA AGGAACTGACCAGAACTGGGCTCAGAAGCTCTATGACCGGCACTCCAGCAGCCAGCACTTCCAGAAGCCCCGCATGTCCAACACGGCCTT CATCATCGTCCACTTTGCAGACAAGGTGGAGTACCTCTCTGATGGTTTTCTGGAGAAAAACAGAGACACGGTGTATGAAGAGCAGATCAA TATCCTGAAGGCCAGCAAGTTCCCACTAGTGGCTGACTTGTTTCATGATGACAAGGACCCTGTTCCTGCCACCACCCCTGGGAAGGGGTC ATCTTCGAAGATCAGCGTCCGTTCTGCCAGACCCCCCATGAAAGTCTCCAACAAGGAGCACAAGAAAACCGTTGGCCACCAGTTCCGTAC CTCCCTGCATCTGCTCATGGAGACCCTGAATGCCACGACACCTCACTATGTCCGCTGCATCAAGCCCAACGATGAGAAGCTCCCCTTTCA CTTTGACCCAAAGAGAGCAGTGCAGCAACTCAGAGCCTGCGGGGTGTTGGAGACGATTCGAATCAGTGCAGCTGGCTACCCATCCAGGTG GGCCTACCATGACTTTTTCAACCGGTATCGGGTGCTGGTCAAGAAGAGAGAGCTCGCCAACACAGACAAAAAGGCCATCTGCAGGTCTGT CCTGGAGAACCTCATCAAGGACCCCGACAAGTTCCAGTTTGGCCGCACCAAGATCTTCTTTCGAGCAGGCCAGGTGGCCTACCTGGAGAA GCTGCGGGCTGACAAGTTCCGGACAGCCACCATCATGATCCAGAAAACTGTCCGGGGATGGCTGCAGAAGGTGAAATATCACAGGCTGAA GGGGGCTACCTTAACCCTGCAGAGGTACTGCCGGGGACACCTGGCCCGCAGGCTGGCTGAGCACCTGCGGAGGATCAGAGCGGCTGTGGT GCTCCAGAAACATTACCGCATGCAGAGGGCCCGCCAGGCCTACCAGAGGGTCCGCAGAGCTGCCGTTGTTATCCAGGCCTTCACCCGGGC CATGTTTGTGCGGAGAACCTACCGCCAGGTCCTCATGGAGCACAAGGCCACCACCATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAG GCACTTCCAGCGGCTGCGGGATGCAGCCATTGTCATCCAGTGTGCCTTCCGGATGCTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGAT TGAGGCCCGCTCAGCAGAGCATCTGAAACGTCTCAACGTGGGCATGGAGAACAAGGTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAA CAAAGAGTTCAAGACACTTTCAGAGCAGTTGTCCGTGACCACCTCAACATACACCATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCA CTACCAGCAGAGCCCAGGTGAGGACACCAGCCTCAGGCTGCAGGAGGAGGTGGAGAGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGA GCGCAAGATCTTGGAGGACGCCCACAGCAGGGAGAAAGATGAGCTGAGGAAGCGAGTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAA AGATGAGAAAGAACAGCTCAACAACCAAATCCTGTGCCAGTCTAAAGATGAATTTGCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAA AGAACTGGAGGAGGAGCGATCCCGGTACCAGAACCTTGTGAAGGAATATTCACAGTTGGAGCAGAGATACGACAACCTTCGGGATGAAAT GACCATCATAAAGCAAACTCCAGGTCATAGGCGGAACCCATCAAACCAAAGTAGCTTAGAATCTGACTCCAATTACCCCTCCATCTCCAC ATCTGAGATCGGAGACACTGAGGATGCCCTCCAGCAGGTGGAGGAAATTGGCCTGGAGAAGGCAGCCATGGACATGACGGTCTTCCTGAA GCTGCAGAAGAGAGTACGGGAGCTGGAGCAGGAGAGGAAAAAGCTGCAAGTGCAGCTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGT CCAGGCGGAACCACCACAGACTGACATAGATTTGGACCCGAATGCAGATCTGGCCTACAATAGTCTGAAGAGGCAAGAGCTGGAGTCAGA GAACAAAAAGCTGAAGAATGACCTGAATGAGCTGAGGAAAGCCGTGGCCGACCAAGCCACGCAGAATAACTCCAGCCACGGCTCCCCAGA TAGCTACAGCCTCCTGCTGAACCAGCTCAAGCTGGCCCACGAGGAGCTCGAGGTGCGCAAGGAGGAGGTGCTCATCCTCAGGACCCAGAT CGTGAGCGCCGACCAGCGGCGACTCGCCGGCAGGAACGCGGAGCCGAACATTAATGCCAGATCAAGTTGGCCTAACAGTGAAAAGCATGT TGACCAGGAGGATGCCATTGAGGCCTATCACGGGGTCTGCCAGACAAACAGCAAGACTGAGGATTGGGGATATTTAAATGAAGATGGAGA ACTCGGCTTGGCCTACCAAGGCCTAAAGCAAGTTGCCAGGCTGCTGGAGGCTCAGCTGCAGGCCCAGAGCCTGGAGCATGAGGAGGAGGT GGAGCATCTCAAGGCTCAGCTCGAGGCCCTGAAGGAGGAGATGGACAAACAGCAGCAGACCTTCTGCCAGACGCTACTGCTCTCCCCAGA GGCCCAGGTGGAATTCGGCGTTCAGCAGGAAATATCCCGGCTGACCAACGAGAATCTGGACCTTAAAGAACTGGTAGAAAAGCTGGAAAA GAATGAGAGGAAGCTCAAAAAGCAACTGAAGATTTACATGAAGAAAGCCCAGGACCTAGAAGCTGCCCAGGCATTGGCCCAGAGTGAGAG GAAGCGCCATGAGCTCAACAGGCAGGTCACGGTCCAGCGGAAAGAGAAGGATTTCCAGGGCATGCTGGAGTACCACAAAGAGGACGAGGC CCTCCTCATCCGGAACCTGGTGACAGACTTGAAGCCCCAGATGCTGTCGGGCACAGTGCCCTGTCTCCCCGCCTACATCCTCTACATGTG CATCCGGCACGCGGACTACACCAACGACGATCTCAAGGTGCACTCCCTGCTGACCTCCACCATCAACGGCATTAAGAAAGTCCTGAAAAA GCACAATGATGACTTTGAGATGACGTCATTCTGGTTATCCAACACCTGCCGCCTTCTTCACTGTCTGAAGCAGTACAGCGGGGATGAGGG CTTCATGACTCAGAACACTGCAAAGCAGAATGAACACTGTCTTAAGAATTTTGACCTCACCGAATACCGTCAGGTGCTGAGTGACCTTTC CATTCAGATCTACCAGCAGCTCATTAAAATTGCCGAGGGCGTGTTACAGCCGATGATAGTTTCTGCCATGTTGGAAAATGAGAGCATTCA GGGTCTATCTGGTGTGAAGCCCACCGGCTACCGGAAGCGCTCCTCCAGCATGGCAGATGGGGATAACTCATACTGCCTGGAAGCTATCAT CCGCCAGATGAATGCCTTTCATACAGTCATGTGTGACCAGGGCTTGGACCCTGAGATCATCCTGCAGGTATTCAAACAGCTCTTCTACAT GATCAACGCAGTGACTCTTAACAACCTGCTCTTGCGGAAGGACGTCTGCTCTTGGAGCACAGGCATGCAACTCAGGTACAATATAAGTCA GCTTGAGGAGTGGCTTCGGGGAAGAAACCTTCACCAGAGTGGAGCAGTTCAGACCATGGAACCTCTGATCCAAGCAGCCCAGCTCCTGCA ATTAAAGAAGAAAACCCAGGAGGACGCAGAGGCTATCTGCTCCCTGTGTACCTCCCTCAGCACCCAGCAGATTGTCAAAATTTTAAACCT TTATACTCCCCTGAATGAATTTGAAGAACGGGTAACAGTGGCCTTTATACGAACAATCCAGGCACAACTACAAGAGCGGAATGACCCTCA GCAACTGCTATTAGATGCCAAGCACATGTTTCCTGTTTTGTTTCCATTTAATCCATCTTCTCTAACCATGGACTCAATCCACATCCCAGC GTGTCTCAATCTGGAATTCCTCAATGAAGTCTGAAGATGCATGTTTCCAGCATTAGTTTGATTCCCAATGTGAGCAAGAAGGAAGTATAT ACAGTAAAGTAAATTCAAGGATCTGTTAAATCTGGTAAAAGTAGATCAAATCAGAGATTGACAGCCTGTGGAGGGTGCTGAACTATACAG AATTAGACACAACTATGTCATTATTTTTTGTACCTACTGCTCAGAATAAAAACACTTGAAATATGGAAGATTTTAAGTTTGATTTCAGTC CAACACATATACATAATTTATAGACACCAAGCAGTCCCCATAGACATATAAAAGGTGTCAATTCTATAAAACGAAGCTGCCTAGTTTTGA TCTTTGCATAGAACTAGAGAATGTCCAAATTAAAATACCAAATATATATAAGTCACATAAATTGCCTTCAAAGGGCTTTAACAAATAATG GTACTAATAACCATGATAATGGCATATACTGACATTTCCCAAAGTTTGCAAACCATAGGTGTGGTTGAGTTTGTGGTGAGATGTTTTAAG AACAAAAATATGGGGATGAGACTTCTGAGAAATATTCCCAAAATATTTTTTAATGGCTGATTATACACAGACAGTGGTGTAACTGACCTC CAGACCAGACATTTTGAGTACTGGTTTCTGAAGCAAAATTAGAAGTGCCAGTCCTCAGTGTGCTCAAACGCTTTTGTGTTATCTTGATTT AATGGAAGAGATTATTAAAATGCTGCTATCCCAAACTCCAAGTGAGAAAGATGGAAAAATATTTTGTTTCTGATGCTAGTCCATACACTT TCCAAGTCCCACAAAACTTTCACAAAAATGTATATAAGCTAAATATTAGAAACGGATAACAAACTTGTTTTATTTATAGATGTAAAAACC AAACAAGTCAATATGAAAGCTTTTAATCTCTTAATACCATTAAGCTTCCAGTAAGAGCATCACATAATGCTCTACTGTTCCAGAAACCAA ATAGTAAAACAAACTAAAGTTCGCACATCAGATCATCTGAAAAACCTTCAAAAATAATCAGTTCAGGGATATTATACAAAAGTTTGGGTT TTTTTTTTTTAAGAGAATAAAATGGCTTAGGTCAACTTTCCCTTTTCAGGTTATTTTCAACGTTTTTCAAATTTAGCACACAAAAAATTG TAAATATCTCTCCCACAAAATAAGGATTTTAAAAAAGTAATTCAGTAATATAACAGGCTTAGATGTTTGCTGCTCTTAGAATTTTTTTTA ACTTGTTTTTGGTTTCTTCAAAAGCAAGCATTCAATTGGAAACCCATATTCTTTCCACACTTTTTTTTACTGTCTTTTCTGTATTTCTTG ATAGCAGTATGCTGTTCCCATAAGAAAAAAATGGTATTTGCAAATCATGGAAGAACAGCCTCTGTATTACATTGAGAAAATAAGATTTAT CCATGAATTGGAAGTAGAACAGCCTGCCTTCACCCTCTTTTACTCAACCACCCAACTTAAAAGGCTCTTGGAAACACAGCACACTCCACG CTACCTTCTGCACTGTGCCCTTAGAGCACAGCTTCCTCAGTTGTTCTCTGCATCTCCTGGGGCTTAGGCCAGTCTTAGCCTGGGTTAAGG CTGCTGACATTGTGTTCCAATCAGTTGTCATGGGCATTATCCCCTCTACATCCACATTAAACATGCCGGCTTCTCTTGGGCATCGGCAGA GCTGTGCCTTTTTCTTTCAGTTACAGTTACATAATCACTGACGTCCATGACACTTACCCATGGATCCATGTGCTGACTTCATTTAGAAGG CCAATCTAAAACAACTGGGTTTGTGGCTACCTCTTTAAAGTTGTTTGTGAAGGATAATTTGTTTTTTAATGCACTTTAGTTTGAAAGTGA GTCTCTTATGTAAGGACCATCCTTAAAAGACCAAAAATGCCTTGTTAGAGTGTTAAGGAGTTTTGACATGCAGTGGTTCCACAAACACAG TGGCTTACTATCCTTATACACTGTCTTATACCATCATTCTCTCCATCTCTCTTGGTCACTACTCTCTGCTGTCACTGGTTAATCACTAGG TGCCAAGAGCTTACTGAATAAAAGCTTGGCAATTAGAATAAATGGGGAGGGAAGGACCTTATGAATAGTCCATTTAGCCTAAGAAATGGC AGATTTAGTTCTTCTCTTCCAAAAGATAAAGGTATATCCTGGAATTGTACTTAAAACTTACAGATGACTAACAAATATATACTTTATATG TAGTTAATATTTAGATCTGTCTTATTTAATACTTGGAGGCTAGAAGAAGCATCTTTAGGGGAACTATATAATCTTTTGTTAGCATTTTCT CTGCATTTTAAAAAATCATTTCAATTCAAACATTTATCAGTGTCATGAAATCAGTAATGACTCTTTAACAATTCAGGTTTGAACTCTGCA TTAGATGTCTCTTTAATTTTTTAATATTTAAAATTTAGTTGACATTTTTTTCACCAGGTGCCTTTAGCGGTTACTAAGATAACTGACATC AGTTGTTTCTCTGAAATAAGTGTTGCTGTGGGAATAATTTTAATGTTCAAGGTGATATCATGGGGGAGTTTTGTCTTTTAAAACATTAGA AGCATTTTAAATATTAAGAATCAAATATTTATAGATCAAAACTTGTGTTTTAAGTATTATACGGGACCTGTTTACTTATAGTAAATGTGA ATGTACACATGAGTTGTTGCTGAAGCTGACAAGCATATTACATACATGCATTTTCCCTGTGCCCTCATAGTTGCAGTTAGAGTTCCAGTA CCTGTAGGCTCACCTGGGAGGCAGATTAGACCCAAAGGTAGATGTTTTTCCCCTTTCCATGAAGCATGTCAGTGGGAGTTGCTTCCTTTG ATTTCCCTAGTACTAAATTTTAAGGCTTTTGTAAAAACAAAACAAAACTAGGAGCTTGGAACAGTTAAAAATCAACACTGCTACCATCAA TTCATCAAATATTTACTTAGAGCTTTCATACATTAAGATTCCAGTAACCAATAAATTAGAATTCATTTCTTCTGCATAAAGTAAATTTTC ATACACTTGACCTACTAAGACAGCAAGGGTGTCCTAAATTGAGGCATTTGTATAATGCCTGCATAACTAAATGGTCACTAAAATGGGACA GCATGGGGCAAGACCTTGTAGTTCTTCACAGAATATTTGTGGTCAGTTTCTCCAATTAATTTGCTGCATGAGCCAAATAACCATAATTCA CTTTTTATACCCACTGGTGCCATAATTAGAGAATTAGAGGGTGTAGACAGAGGTTAATGCCAATGAGAAACACAGGACAGGGTTTTTTTT ATTATAAAGGTCATTAGATACAAAAGATTGTTTTTCAAAAAATTTCTAATTCTAACAAAGGGGATCAATCAGAAATGAAACTAAGCTACT TTCTAAAGTGACACTGTATCAGAATAATCCAGATTTGAATATAACATTTTGCCACCAACTGACATTTAGATGAAGGACTGCCTCTCTGAA AGAGTTCAGATCATATTCAGGGGTGAATCCAACACCATGGAAGAAAGACTACTGATGAAAATATTTTCCCACTTTGCACAAATCTGTAAA CTACACCTTTGTTTATAGAAAAATGCTTGTAATAGTCACTGTAATATTTAGCTGTGGATAAAAATTTGTGGAAATAAATACTTTTGAATA >41269_41269_2_KATNAL2-MYO5B_KATNAL2_chr18_44526886_ENST00000592005_MYO5B_chr18_47581748_ENST00000285039_length(amino acids)=1882AA_BP=43 MKKIEQRKTRPCFSTSNENRVLAQCLMELSYQTLKFTHQAREACTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQR NQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEA YKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIG ANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIF KIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWI VEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGI LDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDK DPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLET IRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVR GWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATT IQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYT MEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEF AQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGL EKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQ ATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSK TEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNEN LDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGT VPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFD LTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPE IILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KATNAL2-MYO5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KATNAL2-MYO5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KATNAL2-MYO5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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