FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KAZN-MTOR (FusionGDB2 ID:41285)

Fusion Gene Summary for KAZN-MTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: KAZN-MTOR
Fusion gene ID: 41285
HgeneTgene
Gene symbol

KAZN

MTOR

Gene ID

23254

2475

Gene namekazrin, periplakin interacting proteinmechanistic target of rapamycin kinase
SynonymsC1orf196|KAZFRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
Cytomap

1p36.21

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionkazrinserine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o
Modification date2020031320200329
UniProtAcc

Q674X7

TLDC1

Ensembl transtripts involved in fusion geneENST00000361144, ENST00000376030, 
ENST00000400797, ENST00000400798, 
ENST00000422387, ENST00000503743, 
ENST00000376838, ENST00000495435, 
ENST00000361445, 
Fusion gene scores* DoF score15 X 11 X 8=132012 X 11 X 8=1056
# samples 1819
** MAII scorelog2(18/1320*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1056*10)=-2.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAZN [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAZN(15251068)-MTOR(11206848), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTOR

GO:0001558

regulation of cell growth

18762023

TgeneMTOR

GO:0001934

positive regulation of protein phosphorylation

20233713

TgeneMTOR

GO:0006468

protein phosphorylation

12150926|15467718|18925875

TgeneMTOR

GO:0009267

cellular response to starvation

28223137

TgeneMTOR

GO:0010507

negative regulation of autophagy

30704899

TgeneMTOR

GO:0016242

negative regulation of macroautophagy

25327288

TgeneMTOR

GO:0016310

phosphorylation

11853878|25327288

TgeneMTOR

GO:0031667

response to nutrient levels

29750193

TgeneMTOR

GO:0034198

cellular response to amino acid starvation

22424946

TgeneMTOR

GO:0038202

TORC1 signaling

28223137

TgeneMTOR

GO:0043200

response to amino acid

18497260

TgeneMTOR

GO:0045727

positive regulation of translation

18762023

TgeneMTOR

GO:0046777

protein autophosphorylation

15467718

TgeneMTOR

GO:0071230

cellular response to amino acid stimulus

22424946

TgeneMTOR

GO:0071233

cellular response to leucine

22424946

TgeneMTOR

GO:1990253

cellular response to leucine starvation

22424946


check buttonFusion gene breakpoints across KAZN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTOR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A3JQ-01AKAZNchr1

15251068

-MTORchr1

11206848

-
ChimerDB4UCECTCGA-D1-A3JQ-01AKAZNchr1

15251068

+MTORchr1

11206848

-


Top

Fusion Gene ORF analysis for KAZN-MTOR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361144ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
5CDS-intronENST00000361144ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-
In-frameENST00000361144ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-3CDSENST00000376030ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-3CDSENST00000400797ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-3CDSENST00000400798ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-3CDSENST00000422387ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-3CDSENST00000503743ENST00000361445KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000376030ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000376030ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000400797ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000400797ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000400798ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000400798ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000422387ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000422387ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000503743ENST00000376838KAZNchr1

15251068

+MTORchr1

11206848

-
intron-intronENST00000503743ENST00000495435KAZNchr1

15251068

+MTORchr1

11206848

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361144KAZNchr115251068+ENST00000361445MTORchr111206848-447344320835221104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361144ENST00000361445KAZNchr115251068+MTORchr111206848-0.0034261510.9965739

Top

Fusion Genomic Features for KAZN-MTOR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KAZN-MTOR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:15251068/chr1:11206848)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAZN

Q674X7

MTOR

TLDC1

FUNCTION: Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}.456

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530582182_251615232550.0DomainPI3K/PI4K
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530582517_254915232550.0DomainFATC
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581542_157415232550.0RepeatNote=TPR 7
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581575_161415232550.0RepeatNote=TPR 8
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581615_164915232550.0RepeatNote=TPR 9
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581650_169315232550.0RepeatNote=TPR 10
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581694_173115232550.0RepeatNote=TPR 11
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581732_178615232550.0RepeatNote=TPR 12
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581787_184615232550.0RepeatNote=TPR 13
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581898_193015232550.0RepeatNote=TPR 14
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581931_197015232550.0RepeatNote=TPR 15
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581971_200515232550.0RepeatNote=TPR 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+1874_25669416.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+11574_2560776.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+1874_2560328.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+1874_2560328.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+1874_2560422.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+1974_2560422.0Coiled coilOntology_term=ECO:0000255
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+18375_38269416.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+115375_3820776.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+18375_3820328.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+18375_3820328.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+18375_3820422.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+19375_3820422.0Compositional biasNote=Poly-Lys
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+18446_51169416.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+18524_58869416.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+18612_67969416.0DomainSAM 3
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+115446_5110776.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+115524_5880776.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+115612_6790776.0DomainSAM 3
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+18446_5110328.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+18524_5880328.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+18612_6790328.0DomainSAM 3
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+18446_5110328.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+18524_5880328.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+18612_6790328.0DomainSAM 3
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+18446_5110422.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+18524_5880422.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+18612_6790422.0DomainSAM 3
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+19446_5110422.0DomainSAM 1
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+19524_5880422.0DomainSAM 2
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+19612_6790422.0DomainSAM 3
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581382_198215232550.0DomainFAT
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058100_13715232550.0RepeatNote=HEAT 3
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581029_106815232550.0RepeatNote=HEAT 25
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581069_110515232550.0RepeatNote=HEAT 26
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581106_114415232550.0RepeatNote=HEAT 27
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581145_118815232550.0RepeatNote=HEAT 28
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581189_122515232550.0RepeatNote=HEAT 29
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581226_127315232550.0RepeatNote=HEAT 30
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581274_131115232550.0RepeatNote=HEAT 31
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581312_134515232550.0RepeatNote=HEAT 32
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581346_138215232550.0RepeatNote=TPR 1
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581383_140815232550.0RepeatNote=TPR 2
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058138_17915232550.0RepeatNote=HEAT 4
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581409_144215232550.0RepeatNote=TPR 3
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581443_147315232550.0RepeatNote=TPR 4
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581474_150715232550.0RepeatNote=TPR 5
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581508_154115232550.0RepeatNote=TPR 6
TgeneMTORchr1:15251068chr1:11206848ENST00000361445305816_5315232550.0RepeatNote=HEAT 1
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058180_22015232550.0RepeatNote=HEAT 5
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058222_27615232550.0RepeatNote=HEAT 6
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058277_31315232550.0RepeatNote=HEAT 7
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058314_36415232550.0RepeatNote=HEAT 8
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058365_40915232550.0RepeatNote=HEAT 9
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058410_44515232550.0RepeatNote=HEAT 10
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058446_49415232550.0RepeatNote=HEAT 11
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058495_52915232550.0RepeatNote=HEAT 12
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058530_56315232550.0RepeatNote=HEAT 13
TgeneMTORchr1:15251068chr1:11206848ENST00000361445305855_9915232550.0RepeatNote=HEAT 2
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058564_59615232550.0RepeatNote=HEAT 14
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058597_63615232550.0RepeatNote=HEAT 15
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058637_68315232550.0RepeatNote=HEAT 16
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058686_72415232550.0RepeatNote=HEAT 17
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058727_76615232550.0RepeatNote=HEAT 18
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058769_81115232550.0RepeatNote=HEAT 19
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058814_85315232550.0RepeatNote=HEAT 20
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058857_89315232550.0RepeatNote=HEAT 21
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058894_94215232550.0RepeatNote=HEAT 22
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058943_98815232550.0RepeatNote=HEAT 23
TgeneMTORchr1:15251068chr1:11206848ENST000003614453058989_102715232550.0RepeatNote=HEAT 24


Top

Fusion Gene Sequence for KAZN-MTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41285_41285_1_KAZN-MTOR_KAZN_chr1_15251068_ENST00000361144_MTOR_chr1_11206848_ENST00000361445_length(transcript)=4473nt_BP=443nt
AGCCGTTCCCACGTGAGAGGCTCCGCGGCCGAATTCCTCGCGTGCAGCAGGCGCGGACCGCCCGGCGTCCGGCCGGACTGAGAGCCCTGG
TCCGGCGCGCGCCGCCGGCCGGGCGGGAGGCGGGGGCGGGCTCGGCTGCGCCCCGATGCGGCGGCGACCTCCGGGTCTGTGAGCCCGGCG
CGCGCCGTCGGAGCCCCTCGCGCAGCCGCTGGTAGCGTCCCCCCGGGCACCCGGCATGCGGGCGGCCGACTCGGGCTCGTGGGAGCGCGT
CCGCCAGCTCGCGGCGCAGGGCGAGCCGGCGCCTTCCTGCGGGGCGGGGGCCGGGCCCGCGCGGCCCCCGGGACCCGCAGCCTGCGAGCA
GTGCGTGGACGCGGCGGGGCCCGGCGATCGGCCCCGCGCCGGGGTTCCCCGGGTCCGAGCGGATGGCGACTGCAGCCAGCCCGGTCAGTG
GGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCT
CTTCTCCTTGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGC
ATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCG
CCAGATCTGGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCC
TCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCT
CCTGGGAGTTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAA
GAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGA
CCAGCAGCATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGA
GAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGAT
GAACTTCGAAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCAC
CAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCAC
CGAGAACAGCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCA
GGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTG
GCCAGATGTCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAAT
TGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACT
GACAGTGGCTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGT
CCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCG
TTTGTACTTTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAA
GGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGA
CCTCACCCAAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGT
TTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCAT
AGCACCGTCTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCT
AAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCT
TCGGAAAAACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACT
GCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGA
CCACTTGACTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAA
AAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCT
GGGAGATAGACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTAT
GACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTA
CAGAATCACATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTT
GCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGA
AATTTTGGACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGG
TTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGA
TGACACTTTGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTG
CCCTTTCTGGTAACTGGAGGCCCAGATGTGCCCATCACGTTTTTTCTGAGGCTTTTGTACTTTAGTAAATGCTTCCACTAAACTGAAACC
ATGGTGAGAAAGTTTGACTTTGTTAAATATTTTGAAATGTAAATGAAAAGAACTACTGTATATTAAAAGTTGGTTTGAACCAACTTTCTA
GCTGCTGTTGAAGAATATATTGTCAGAAACACAAGGCTTGATTTGGTTCCCAGGACAGTGAAACATAGTAATACCACGTAAATCAAGCCA
TTCATTTTGGGGAACAGAAGATCCATAACTTTAGAAATACGGGTTTTGACTTAACTCACAAGAGAACTCATCATAAGTACTTGCTGATGG
AAGAATGACCTAGTTGCTCCTCTCAACATGGGTACAGCAAACTCAGCACAGCCAAGAAGCCTCAGGTCGTGGAGAACATGGATTAGGATC
CTAGACTGTAAAGACACAGAAGATGCTGACCTCACCCCTGCCACCTATCCCAAGACCTCACTGGTCTGTGGACAGCAGCAGAAATGTTTG
CAAGATAGGCCAAAATGAGTACAAAAGGTCTGTCTTCCATCAGACCCAGTGATGCTGCGACTCACACGCTTCAATTCAAGACCTGACCGC
TAGTAGGGAGGTTTATTCAGATCGCTGGCAGCCTCGGCTGAGCAGATGCACAGAGGGGATCACTGTGCAGTGGGACCACCCTCACTGGCC
TTCTGCAGCAGGGTTCTGGGATGTTTTCAGTGGTCAAAATACTCTGTTTAGAGCAAGGGCTCAGAAAACAGAAATACTGTCATGGAGGTG
CTGAACACAGGGAAGGTCTGGTACATATTGGAAATTATGAGCAGAACAAATACTCAACTAAATGCACAAAGTATAAAGTGTAGCCATGTC

>41285_41285_1_KAZN-MTOR_KAZN_chr1_15251068_ENST00000361144_MTOR_chr1_11206848_ENST00000361445_length(amino acids)=1104AA_BP=78
MVASPRAPGMRAADSGSWERVRQLAAQGEPAPSCGAGAGPARPPGPAACEQCVDAAGPGDRPRAGVPRVRADGDCSQPGQWDSMEEYTCM
IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQG
CQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQ
HMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYK
HQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLS
RGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTT
ARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYG
RDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITS
KQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYRE
KKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLM
LDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTN
TKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KAZN-MTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530582258_22961523.33333333333332550.0MLST8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAZNchr1:15251068chr1:11206848ENST00000361144+18174_33369.33333333333333416.0PPL
HgeneKAZNchr1:15251068chr1:11206848ENST00000376030+115174_3330776.0PPL
HgeneKAZNchr1:15251068chr1:11206848ENST00000400797+18174_3330328.0PPL
HgeneKAZNchr1:15251068chr1:11206848ENST00000400798+18174_3330328.0PPL
HgeneKAZNchr1:15251068chr1:11206848ENST00000422387+18174_3330422.0PPL
HgeneKAZNchr1:15251068chr1:11206848ENST00000503743+19174_3330422.0PPL
TgeneMTORchr1:15251068chr1:11206848ENST0000036144530581_6511523.33333333333332550.0NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KAZN-MTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KAZN-MTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource