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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNAB1-KHDRBS1 (FusionGDB2 ID:41342)

Fusion Gene Summary for KCNAB1-KHDRBS1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNAB1-KHDRBS1
Fusion gene ID: 41342
HgeneTgene
Gene symbol

KCNAB1

KHDRBS1

Gene ID

7881

10657

Gene namepotassium voltage-gated channel subfamily A member regulatory beta subunit 1KH RNA binding domain containing, signal transduction associated 1
SynonymsAKR6A3|KCNA1B|KV-BETA-1|Kvb1.3|hKvBeta3|hKvb3Sam68|p62|p68
Cytomap

3q25.31

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionvoltage-gated potassium channel subunit beta-1K(+) channel subunit beta-1K+ channel Beta1a chainpotassium channel beta 3 chainpotassium channel beta3 subunitpotassium channel shaker chain beta 1apotassium channel, voltage gated subfamily A regulatorKH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associa
Modification date2020031320200327
UniProtAcc

Q14722

Q07666

Ensembl transtripts involved in fusion geneENST00000497291, ENST00000302490, 
ENST00000389634, ENST00000389636, 
ENST00000471742, ENST00000490337, 
ENST00000327300, ENST00000307714, 
ENST00000492989, 
Fusion gene scores* DoF score14 X 14 X 3=58811 X 8 X 6=528
# samples 1412
** MAII scorelog2(14/588*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNAB1 [Title/Abstract] AND KHDRBS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNAB1(156249286)-KHDRBS1(32502511), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNAB1

GO:1901379

regulation of potassium ion transmembrane transport

7890032

TgeneKHDRBS1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

TgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

TgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

TgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

TgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532


check buttonFusion gene breakpoints across KCNAB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KHDRBS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IW-A3M6-01AKCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+


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Fusion Gene ORF analysis for KCNAB1-KHDRBS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497291ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
3UTR-3UTRENST00000497291ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
3UTR-3UTRENST00000497291ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000302490ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000302490ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000389634ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000389634ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000389636ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000389636ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000471742ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000471742ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000490337ENST00000307714KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
5CDS-3UTRENST00000490337ENST00000492989KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
In-frameENST00000302490ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
In-frameENST00000389634ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
In-frameENST00000389636ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
In-frameENST00000471742ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+
In-frameENST00000490337ENST00000327300KCNAB1chr3

156249286

-KHDRBS1chr1

32502511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490337KCNAB1chr3156249286-ENST00000327300KHDRBS1chr132502511+30531234641794576
ENST00000389636KCNAB1chr3156249286-ENST00000327300KHDRBS1chr132502511+29361117341677547
ENST00000471742KCNAB1chr3156249286-ENST00000327300KHDRBS1chr132502511+317313542171914565
ENST00000302490KCNAB1chr3156249286-ENST00000327300KHDRBS1chr132502511+380619878202547575
ENST00000389634KCNAB1chr3156249286-ENST00000327300KHDRBS1chr132502511+2848102901589529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490337ENST00000327300KCNAB1chr3156249286-KHDRBS1chr132502511+0.0009943360.99900573
ENST00000389636ENST00000327300KCNAB1chr3156249286-KHDRBS1chr132502511+0.0014351590.9985649
ENST00000471742ENST00000327300KCNAB1chr3156249286-KHDRBS1chr132502511+0.0007456320.9992544
ENST00000302490ENST00000327300KCNAB1chr3156249286-KHDRBS1chr132502511+0.0014325490.99856746
ENST00000389634ENST00000327300KCNAB1chr3156249286-KHDRBS1chr132502511+0.0007371980.99926275

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Fusion Genomic Features for KCNAB1-KHDRBS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNAB1-KHDRBS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:156249286/chr1:32502511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNAB1

Q14722

KHDRBS1

Q07666

FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63143, ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:8938711, ECO:0000269|PubMed:9763623, ECO:0000305}.FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000302490-1314108_109372402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000302490-1314240_241372402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000302490-1314295_300372402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000471742-1314108_109379409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000471742-1314240_241379409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000471742-1314295_300379409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000471742-1314375_381379409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000490337-1314108_109390420.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000490337-1314240_241390420.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000490337-1314295_300390420.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000490337-1314375_381390420.0Nucleotide bindingNADP
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039282_292257444.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039295_301257444.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039302_332257444.0Compositional biasArg/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039334_363257444.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928282_292218405.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928295_301218405.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928302_332218405.0Compositional biasArg/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928334_363218405.0Compositional biasPro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNAB1chr3:156249286chr1:32502511ENST00000302490-1314375_381372402.0Nucleotide bindingNADP
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000003273003934_41257444.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000003273003944_55257444.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000003273003959_89257444.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000004929892834_41218405.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000004929892844_55218405.0Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST000004929892859_89218405.0Compositional biasPro-rich
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039171_197257444.0DomainKH
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928171_197218405.0DomainKH
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039100_260257444.0RegionInvolved in homodimerization
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928100_260218405.0RegionInvolved in homodimerization


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Fusion Gene Sequence for KCNAB1-KHDRBS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41342_41342_1_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000302490_KHDRBS1_chr1_32502511_ENST00000327300_length(transcript)=3806nt_BP=1987nt
AGTTCCAACTGTTGTGCTGCAGCAGATTTGGTCTGAGTCTGGGCAGAGCCCCTTTTTATGGAGCAACCCTCCCGATTTGTTACAGCAAGA
GCCTGGTGCAAGTGATCTTTGCCTTCCCATCGCACACAAAGGCAAAGAGCTCCTTAAAGGGACCTGCCTGCTCCTCCGTGCAGCTGCAAA
CCCGTGTCGGTGCAGGCTCAGCAACCCAGGCTTTCGCTCGAGAATGAGTGGGGAGGGGTCTTGAGGAGCCCCCACGTCCTCCCGGAGCGG
AGGCGGGAGGGAGCTGACAGCCGGAGTGGATGGAGACCACCAGTCCGAGGGGACCCGCTTGCGATTAGCTGCTTCTTGGGATGCTCCGCG
CGCCAGTTGAGCATCCTGCCTGTGGTCCAGGGGATGCTGGCGGCGCATCTTGCGGTAAGCCTGCGCTGATTTGAGCCATCGCCCAGAAGC
GAGCCCGCATTCAGACACCGCGGACCGGCTCCGCGAAGGGCTGCGTGCAGTCACCATGAATGCTCAGCTCTAGGCTTCTGTAAAAACCTC
CCCCACTGCATGGATTTGGCTGTTTAATCAGCCGAGATTACAGCCCGGGAAGATTTGCAAACCTGATTCTCCCTCCAGCTGCTGTGACAA
CTTCGGGGCCGTCTGTTTACTTCTCTGGGTCCCCGGGGACTCTTTCCTGCATCGCAGCCCCTTGTGCCACTTTGTGGGCTTGGCTCGAAA
GTCAGCCGCCAGGACTCCTCTGACGGCATCCCCAGGAAGGGGGAGCAAGGAGGGCTTAAAAGAAAAGCAGAAATCCCCGCAACTGCTCAA
CCTCTCGTGACTGCCTGTGTTCTGGGGTTCTGAGAGGGACCGTGCGCTGCCTGGGGAAGCAATGCAAGTCTCCATAGCCTGCACAGAGCA
CAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCCAATGTGGTGAACGCAGCCCGGGCCAAATT
CCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCTCTCAAAGAGTCCACCGCAAAGCAGACTGG
CATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGA
TGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGA
AGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGA
AACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTT
TGCAAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGG
CACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGA
GTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGTTGGCGCAATGACATGGTCTCCACT
TGCCTGTGGAATCATCTCAGGAAAATACGGAAACGGGGTGCCTGAAAGTTCCAGGGCTTCACTGAAGTGCTACCAGTGGTTGAAAGAAAG
AATTGTAAGTGAAGAAGGGAGAAAACAGCAAAACAAGCTAAAAGACCTTTCCCCAATTGCGGAGCGTCTGGGATGCACACTACCTCAGCT
AGCTGTTGCGTGGTGCCTGAGAAATGAAGGTGTGAGTTCTGTGCTCCTGGGATCATCCACTCCTGAACAACTCATTGAAAACCTTGGTGC
CATTCAGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGG
GGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACG
TGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACC
AAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATA
CGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCA
AGATTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATA
CAGAGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCC
CAGGATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATT
CTTAACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAG
ATGCTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAAC
CTGTTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGT
AAAGTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGG
CACCACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAA
TATGAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAAC
TGACTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGT
TGATGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAAT
TAAATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAG
CTGTTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAG
GGACACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGT
TCTCGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTATGTCAAAATGTCTGCAGCAGTTTGTCAATAAAG

>41342_41342_1_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000302490_KHDRBS1_chr1_32502511_ENST00000327300_length(amino acids)=575AA_BP=388
MPVFWGSERDRALPGEAMQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKY
RNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETER
GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHL
FQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVA
WCLRNEGVSSVLLGSSTPEQLIENLGAIQDMMDDICQEQFLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTP
VRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHGEVQDSY

--------------------------------------------------------------
>41342_41342_2_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000389634_KHDRBS1_chr1_32502511_ENST00000327300_length(transcript)=2848nt_BP=1029nt
ATGCAAGTCTCCATAGCCTGCACAGAGCACAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCC
AATGTGGTGAACGCAGCCCGGGCCAAATTCCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCT
CTCAAAGAGTCCACCGCAAAGCAGACTGGCATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACA
TGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACT
GCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACA
ACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACAT
GTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTC
AATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAA
ATAGGTGTTGGCGCAATGACATGGTCTCCACTTGCCTGTGGAATCATCTCAGGAAAATACGGAAACGGGGTGCCTGAAAGTTCCAGGGCT
TCACTGAAGTGCTACCAGTGGTTGAAAGAAAGAATTGTAAGTGAAGAAGGGAGAAAACAGCAAAACAAGCTAAAAGACCTTTCCCCAATT
GCGGAGCGTCTGGGATGCACACTACCTCAGCTAGCTGTTGCGTGGTGCCTGAGAAATGAAGGTGTGAGTTCTGTGCTCCTGGGATCATCC
ACTCCTGAACAACTCATTGAAAACCTTGGTGCCATTCAGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTG
AATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGT
GGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCA
CCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAA
ACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCA
GAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAG
GCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTAT
GAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCG
TGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTT
AGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAA
AGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAA
GTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAA
GATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCA
CATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAA
AAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGAT
ACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCC
ATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCA
TGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCA
AGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTC
CTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTAT

>41342_41342_2_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000389634_KHDRBS1_chr1_32502511_ENST00000327300_length(amino acids)=529AA_BP=342
MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGT
WVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEEIVRAMTH
VINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRA
SLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQDMMDDICQEQFLELSYL
NGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPE

--------------------------------------------------------------
>41342_41342_3_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000389636_KHDRBS1_chr1_32502511_ENST00000327300_length(transcript)=2936nt_BP=1117nt
AGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGCGGGGAGTCAGATCTCAGAGGAGAACACCAA
GTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTCAGAAAACGCTAAAGACAGCAGCCTTAGTCC
CTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAACTGGTACCTAAAGCTCTGCGACCTGTCCAG
CGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATG
GGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGC
CGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAAC
CAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACATGT
GATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAA
TATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAAT
AGGTGTTGGCGCAATGACATGGTCTCCACTTGCCTGTGGAATCATCTCAGGAAAATACGGAAACGGGGTGCCTGAAAGTTCCAGGGCTTC
ACTGAAGTGCTACCAGTGGTTGAAAGAAAGAATTGTAAGTGAAGAAGGGAGAAAACAGCAAAACAAGCTAAAAGACCTTTCCCCAATTGC
GGAGCGTCTGGGATGCACACTACCTCAGCTAGCTGTTGCGTGGTGCCTGAGAAATGAAGGTGTGAGTTCTGTGCTCCTGGGATCATCCAC
TCCTGAACAACTCATTGAAAACCTTGGTGCCATTCAGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTGAA
TGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGTGG
TGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCACC
CCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAAAC
ATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCAGA
ATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAGGC
CCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTATGA
GCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCGTG
GTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTTAG
GAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAAAG
AAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAAGT
TTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAAGA
TTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCACA
TGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAAAA
AAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGATAC
TTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCCAT
GAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCATG
AAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCAAG
TATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTCCT
AATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTATGT

>41342_41342_3_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000389636_KHDRBS1_chr1_32502511_ENST00000327300_length(amino acids)=547AA_BP=360
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLA
CGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAI
QDMMDDICQEQFLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPR
ARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHGEVQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYR

--------------------------------------------------------------
>41342_41342_4_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000471742_KHDRBS1_chr1_32502511_ENST00000327300_length(transcript)=3173nt_BP=1354nt
ATGCACAGGCCTGGGCAGGGACACACAACCAACAGCTCTGTCGGGAACTTAGGAGCCTGCTCGCCTACAAAAATGATAAGAGAGATCTAA
AGAAAACAAGCTAAACCTTTTGAGGGACATACTGAAGCCAGATAACCCAAGGTATTCACAGCAAGATACAGTGAGTCTTAAAGTTAAGCA
CCGTGCAATTAGCTTTGCTTCCTTGGGTTTTTGAAACATGCATCTGTATAAACCTGCCTGTGCAGACATCCCGAGCCCCAAGCTGGGTCT
GCCAAAATCCAGTGAATCGGCTCTAAAATGTAGATGGCACCTAGCAGTGACCAAGACTCAGCCTCAGGCGGCCTGCAAACCTGTGAGGCC
CAGTGGAGCAGCCGAACAGAAATATGTGGAAAAGTTTCTACGTGTTCATGGAATTTCGTTGCAGGAAACCACCAGAGCAGAGACGGGCAT
GGCATACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGA
GGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGT
GATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAAC
AGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGC
AAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCAC
CTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTA
CCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGTTGGCGCAATGACATGGTCTCCACTTGC
CTGTGGAATCATCTCAGGAAAATACGGAAACGGGGTGCCTGAAAGTTCCAGGGCTTCACTGAAGTGCTACCAGTGGTTGAAAGAAAGAAT
TGTAAGTGAAGAAGGGAGAAAACAGCAAAACAAGCTAAAAGACCTTTCCCCAATTGCGGAGCGTCTGGGATGCACACTACCTCAGCTAGC
TGTTGCGTGGTGCCTGAGAAATGAAGGTGTGAGTTCTGTGCTCCTGGGATCATCCACTCCTGAACAACTCATTGAAAACCTTGGTGCCAT
TCAGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGT
GCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGG
TACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAG
AGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGC
AGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGA
TTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAG
AGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAG
GATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTT
AACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATG
CTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTG
TTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAA
GTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCAC
CACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATAT
GAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGA
CTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGA
TGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAA
ATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTG
TTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGA
CACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCT
CGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTATGTCAAAATGTCTGCAGCAGTTTGTCAATAAAGTTT

>41342_41342_4_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000471742_KHDRBS1_chr1_32502511_ENST00000327300_length(amino acids)=565AA_BP=378
MHLYKPACADIPSPKLGLPKSSESALKCRWHLAVTKTQPQAACKPVRPSGAAEQKYVEKFLRVHGISLQETTRAETGMAYRNLGKSGLRV
SCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEG
LKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQL
PELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSS
VLLGSSTPEQLIENLGAIQDMMDDICQEQFLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGAT
VTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHGEVQDSYEAYGQDDWNG

--------------------------------------------------------------
>41342_41342_5_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000490337_KHDRBS1_chr1_32502511_ENST00000327300_length(transcript)=3053nt_BP=1234nt
AGAAAAATCAATTCAGATTACTTTGATGACAGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGC
GGGGAGTCAGATCTCAGAGGAGAACACCAAGTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTC
AGAAAACGCTAAAGACAGCAGCCTTAGTCCCTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAA
CTGGTACCTAAAGCTCTGCGACCTGTCCAGCGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACT
CAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTA
TGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGG
CTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTAT
TGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGCAAATCGACCGGACAGTAACACTCCCATGGA
AGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGA
AGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGT
CCAGCTGCCAGAGCTCTACCACAAAATAGGTGTTGGCGCAATGACATGGTCTCCACTTGCCTGTGGAATCATCTCAGGAAAATACGGAAA
CGGGGTGCCTGAAAGTTCCAGGGCTTCACTGAAGTGCTACCAGTGGTTGAAAGAAAGAATTGTAAGTGAAGAAGGGAGAAAACAGCAAAA
CAAGCTAAAAGACCTTTCCCCAATTGCGGAGCGTCTGGGATGCACACTACCTCAGCTAGCTGTTGCGTGGTGCCTGAGAAATGAAGGTGT
GAGTTCTGTGCTCCTGGGATCATCCACTCCTGAACAACTCATTGAAAACCTTGGTGCCATTCAGGATATGATGGATGATATCTGTCAGGA
GCAATTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCC
TCCACCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGG
TGCCACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACC
TTTGCCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTA
TTACAGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTG
GAATGGGACCAGGCCGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGACGTTATTAAAAACA
AACATGAGGGGAAAATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTACCCACAACAGACAA
GTAATTGTCTAAGTGTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGCTTCTGTATGTAGTA
TTTTAAAATGAGTTAAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGTTTAAATATAAACAG
AAGTGTACCTTTTATAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGACATTGCTTGCTTAA
AGGTTCTGAAGTAAAGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAATCCCAAACTAGGCTA
CATTTCAAAATTCAGGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGAGCTCAGACGTCTCT
AAAAAATGTTTCCTTTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAATTAAATAGTTGATG
CAATTTTTAACGTTAATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGGGTTTTGAAATCTAG
CCCCAGACATACTGTGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGAAGGCCTCCTGAATT
GAGTTTGATGCAGAGCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAAAAGACAAAGTATTT
TGTCCATTTGAGATTCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTTGACGGTTGTCAATA
TATCGAACTGTTCCCAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGAAAAAGGAATCAAAA
TCCACTTTGTACATAAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCTACATGTGTAAGTCT

>41342_41342_5_KCNAB1-KHDRBS1_KCNAB1_chr3_156249286_ENST00000490337_KHDRBS1_chr1_32502511_ENST00000327300_length(amino acids)=576AA_BP=389
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYH
LFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAV
AWCLRNEGVSSVLLGSSTPEQLIENLGAIQDMMDDICQEQFLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGT
PVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHGEVQDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNAB1-KHDRBS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039351_443257.0444.0HNRNPA1
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928351_443218.0405.0HNRNPA1
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000032730039400_420257.0444.0ZBTB7A
TgeneKHDRBS1chr3:156249286chr1:32502511ENST0000049298928400_420218.0405.0ZBTB7A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNAB1-KHDRBS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNAB1-KHDRBS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource