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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNAB1-LRTM1 (FusionGDB2 ID:41346)

Fusion Gene Summary for KCNAB1-LRTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNAB1-LRTM1
Fusion gene ID: 41346
HgeneTgene
Gene symbol

KCNAB1

LRTM1

Gene ID

7881

57408

Gene namepotassium voltage-gated channel subfamily A member regulatory beta subunit 1leucine rich repeats and transmembrane domains 1
SynonymsAKR6A3|KCNA1B|KV-BETA-1|Kvb1.3|hKvBeta3|hKvb3HT017
Cytomap

3q25.31

3p14.3

Type of geneprotein-codingprotein-coding
Descriptionvoltage-gated potassium channel subunit beta-1K(+) channel subunit beta-1K+ channel Beta1a chainpotassium channel beta 3 chainpotassium channel beta3 subunitpotassium channel shaker chain beta 1apotassium channel, voltage gated subfamily A regulatorleucine-rich repeat and transmembrane domain-containing protein 1
Modification date2020031320200313
UniProtAcc

Q14722

.
Ensembl transtripts involved in fusion geneENST00000497291, ENST00000302490, 
ENST00000389634, ENST00000389636, 
ENST00000471742, ENST00000490337, 
ENST00000273286, ENST00000493075, 
Fusion gene scores* DoF score14 X 14 X 3=5883 X 2 X 3=18
# samples 144
** MAII scorelog2(14/588*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCNAB1 [Title/Abstract] AND LRTM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNAB1(156233009)-LRTM1(54952919), # samples:1
KCNAB1(156233009)-LRTM1(54959242), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNAB1

GO:1901379

regulation of potassium ion transmembrane transport

7890032


check buttonFusion gene breakpoints across KCNAB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-QT-A5XO-01AKCNAB1chr3

156233009

+LRTM1chr3

54952919

-
ChimerDB4PCPGTCGA-QT-A5XO-01AKCNAB1chr3

156233009

-LRTM1chr3

54959242

-


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Fusion Gene ORF analysis for KCNAB1-LRTM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497291ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
3UTR-3CDSENST00000497291ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
3UTR-3CDSENST00000497291ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
3UTR-5UTRENST00000497291ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
5CDS-5UTRENST00000302490ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
5CDS-5UTRENST00000389634ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
5CDS-5UTRENST00000389636ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
5CDS-5UTRENST00000471742ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
5CDS-5UTRENST00000490337ENST00000493075KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
Frame-shiftENST00000302490ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000302490ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000389634ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000389634ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000389636ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000389636ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000471742ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000471742ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000490337ENST00000273286KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
Frame-shiftENST00000490337ENST00000493075KCNAB1chr3

156233009

+LRTM1chr3

54952919

-
In-frameENST00000302490ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
In-frameENST00000389634ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
In-frameENST00000389636ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
In-frameENST00000471742ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-
In-frameENST00000490337ENST00000273286KCNAB1chr3

156233009

-LRTM1chr3

54959242

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490337KCNAB1chr3156233009-ENST00000273286LRTM1chr354959242-2182929641959631
ENST00000389636KCNAB1chr3156233009-ENST00000273286LRTM1chr354959242-2065812341842602
ENST00000471742KCNAB1chr3156233009-ENST00000273286LRTM1chr354959242-230210492172079620
ENST00000302490KCNAB1chr3156233009-ENST00000273286LRTM1chr354959242-293516828202712630
ENST00000389634KCNAB1chr3156233009-ENST00000273286LRTM1chr354959242-197772401754584

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490337ENST00000273286KCNAB1chr3156233009-LRTM1chr354959242-0.009123020.990877
ENST00000389636ENST00000273286KCNAB1chr3156233009-LRTM1chr354959242-0.0127696130.98723036
ENST00000471742ENST00000273286KCNAB1chr3156233009-LRTM1chr354959242-0.0081308750.9918691
ENST00000302490ENST00000273286KCNAB1chr3156233009-LRTM1chr354959242-0.0150367170.98496324
ENST00000389634ENST00000273286KCNAB1chr3156233009-LRTM1chr354959242-0.0136630160.986337

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Fusion Genomic Features for KCNAB1-LRTM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNAB1-LRTM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:156233009/chr3:54952919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNAB1

Q14722

.
FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63143, ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:8938711, ECO:0000269|PubMed:9763623, ECO:0000305}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000302490-1014108_109270402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000302490-1014240_241270402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000471742-1014108_109277409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000471742-1014240_241277409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000490337-1014108_109288420.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000490337-1014240_241288420.0Nucleotide bindingNADP
TgeneLRTM1chr3:156233009chr3:54959242ENST0000027328603180_2342346.0DomainNote=LRRCT
TgeneLRTM1chr3:156233009chr3:54959242ENST000002732860328_502346.0DomainNote=LRRNT
TgeneLRTM1chr3:156233009chr3:54959242ENST0000049307503180_2340270.0DomainNote=LRRCT
TgeneLRTM1chr3:156233009chr3:54959242ENST000004930750328_500270.0DomainNote=LRRNT
TgeneLRTM1chr3:156233009chr3:54959242ENST0000027328603123_1442346.0RepeatNote=LRR 4
TgeneLRTM1chr3:156233009chr3:54959242ENST0000027328603147_1682346.0RepeatNote=LRR 5
TgeneLRTM1chr3:156233009chr3:54959242ENST000002732860351_722346.0RepeatNote=LRR 1
TgeneLRTM1chr3:156233009chr3:54959242ENST000002732860375_962346.0RepeatNote=LRR 2
TgeneLRTM1chr3:156233009chr3:54959242ENST000002732860399_1202346.0RepeatNote=LRR 3
TgeneLRTM1chr3:156233009chr3:54959242ENST0000049307503123_1440270.0RepeatNote=LRR 4
TgeneLRTM1chr3:156233009chr3:54959242ENST0000049307503147_1680270.0RepeatNote=LRR 5
TgeneLRTM1chr3:156233009chr3:54959242ENST000004930750351_720270.0RepeatNote=LRR 1
TgeneLRTM1chr3:156233009chr3:54959242ENST000004930750375_960270.0RepeatNote=LRR 2
TgeneLRTM1chr3:156233009chr3:54959242ENST000004930750399_1200270.0RepeatNote=LRR 3
TgeneLRTM1chr3:156233009chr3:54959242ENST000002732860328_2882346.0Topological domainExtracellular
TgeneLRTM1chr3:156233009chr3:54959242ENST0000027328603310_3452346.0Topological domainCytoplasmic
TgeneLRTM1chr3:156233009chr3:54959242ENST000004930750328_2880270.0Topological domainExtracellular
TgeneLRTM1chr3:156233009chr3:54959242ENST0000049307503310_3450270.0Topological domainCytoplasmic
TgeneLRTM1chr3:156233009chr3:54959242ENST0000027328603289_3092346.0TransmembraneHelical
TgeneLRTM1chr3:156233009chr3:54959242ENST0000049307503289_3090270.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000302490-1014295_300270402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000302490-1014375_381270402.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000471742-1014295_300277409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000471742-1014375_381277409.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000490337-1014295_300288420.0Nucleotide bindingNADP
HgeneKCNAB1chr3:156233009chr3:54959242ENST00000490337-1014375_381288420.0Nucleotide bindingNADP


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Fusion Gene Sequence for KCNAB1-LRTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41346_41346_1_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000302490_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2935nt_BP=1682nt
AGTTCCAACTGTTGTGCTGCAGCAGATTTGGTCTGAGTCTGGGCAGAGCCCCTTTTTATGGAGCAACCCTCCCGATTTGTTACAGCAAGA
GCCTGGTGCAAGTGATCTTTGCCTTCCCATCGCACACAAAGGCAAAGAGCTCCTTAAAGGGACCTGCCTGCTCCTCCGTGCAGCTGCAAA
CCCGTGTCGGTGCAGGCTCAGCAACCCAGGCTTTCGCTCGAGAATGAGTGGGGAGGGGTCTTGAGGAGCCCCCACGTCCTCCCGGAGCGG
AGGCGGGAGGGAGCTGACAGCCGGAGTGGATGGAGACCACCAGTCCGAGGGGACCCGCTTGCGATTAGCTGCTTCTTGGGATGCTCCGCG
CGCCAGTTGAGCATCCTGCCTGTGGTCCAGGGGATGCTGGCGGCGCATCTTGCGGTAAGCCTGCGCTGATTTGAGCCATCGCCCAGAAGC
GAGCCCGCATTCAGACACCGCGGACCGGCTCCGCGAAGGGCTGCGTGCAGTCACCATGAATGCTCAGCTCTAGGCTTCTGTAAAAACCTC
CCCCACTGCATGGATTTGGCTGTTTAATCAGCCGAGATTACAGCCCGGGAAGATTTGCAAACCTGATTCTCCCTCCAGCTGCTGTGACAA
CTTCGGGGCCGTCTGTTTACTTCTCTGGGTCCCCGGGGACTCTTTCCTGCATCGCAGCCCCTTGTGCCACTTTGTGGGCTTGGCTCGAAA
GTCAGCCGCCAGGACTCCTCTGACGGCATCCCCAGGAAGGGGGAGCAAGGAGGGCTTAAAAGAAAAGCAGAAATCCCCGCAACTGCTCAA
CCTCTCGTGACTGCCTGTGTTCTGGGGTTCTGAGAGGGACCGTGCGCTGCCTGGGGAAGCAATGCAAGTCTCCATAGCCTGCACAGAGCA
CAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCCAATGTGGTGAACGCAGCCCGGGCCAAATT
CCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCTCTCAAAGAGTCCACCGCAAAGCAGACTGG
CATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGA
TGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGA
AGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGA
AACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTT
TGCAAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGG
CACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGA
GTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGAT
TGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGC
CGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTC
AGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGT
TTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAA
CAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGA
TCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAA
ACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCT
TAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGG
TGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCT
GCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCAC
CTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAG
CTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTA
GTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAG

>41346_41346_1_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000302490_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=630AA_BP=287
MPVFWGSERDRALPGEAMQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKY
RNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETER
GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHL
FQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPW
LMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRAL
LESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVL
RPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSPA

--------------------------------------------------------------
>41346_41346_2_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389634_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=1977nt_BP=724nt
ATGCAAGTCTCCATAGCCTGCACAGAGCACAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCC
AATGTGGTGAACGCAGCCCGGGCCAAATTCCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCT
CTCAAAGAGTCCACCGCAAAGCAGACTGGCATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACA
TGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACT
GCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACA
ACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACAT
GTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTC
AATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAA
ATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACA
AATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAG
ATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCT
GGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTC
CCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTT
GCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTC
TGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAA
TCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCC
TCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGC
GAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTC
ATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCT
GGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATA
GTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAA

>41346_41346_2_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389634_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=584AA_BP=241
MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGT
WVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEEIVRAMTH
VINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSST
NFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSL
PQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICE
SPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCL

--------------------------------------------------------------
>41346_41346_3_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389636_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2065nt_BP=812nt
AGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGCGGGGAGTCAGATCTCAGAGGAGAACACCAA
GTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTCAGAAAACGCTAAAGACAGCAGCCTTAGTCC
CTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAACTGGTACCTAAAGCTCTGCGACCTGTCCAG
CGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATG
GGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGC
CGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAAC
CAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACATGT
GATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAA
TATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAAT
AGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAA
TTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGAT
ACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGG
AGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCC
TCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGC
GGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTG
GAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATC
ACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTC
GCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGA
GCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCAT
GATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGG
GAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGT
GTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAA

>41346_41346_3_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389636_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=602AA_BP=259
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGELLLFSSVIV
LLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVL
NLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKL
WLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLR

--------------------------------------------------------------
>41346_41346_4_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000471742_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2302nt_BP=1049nt
ATGCACAGGCCTGGGCAGGGACACACAACCAACAGCTCTGTCGGGAACTTAGGAGCCTGCTCGCCTACAAAAATGATAAGAGAGATCTAA
AGAAAACAAGCTAAACCTTTTGAGGGACATACTGAAGCCAGATAACCCAAGGTATTCACAGCAAGATACAGTGAGTCTTAAAGTTAAGCA
CCGTGCAATTAGCTTTGCTTCCTTGGGTTTTTGAAACATGCATCTGTATAAACCTGCCTGTGCAGACATCCCGAGCCCCAAGCTGGGTCT
GCCAAAATCCAGTGAATCGGCTCTAAAATGTAGATGGCACCTAGCAGTGACCAAGACTCAGCCTCAGGCGGCCTGCAAACCTGTGAGGCC
CAGTGGAGCAGCCGAACAGAAATATGTGGAAAAGTTTCTACGTGTTCATGGAATTTCGTTGCAGGAAACCACCAGAGCAGAGACGGGCAT
GGCATACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGA
GGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGT
GATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAAC
AGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGC
AAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCAC
CTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTA
CCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGT
CCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGA
AATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGT
GCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTT
AAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAA
CATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCG
AGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACT
CTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAG
GATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGT
GGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCG
TCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTA
TGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTC
ACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTC
TGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAGGAA

>41346_41346_4_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000471742_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=620AA_BP=277
MHLYKPACADIPSPKLGLPKSSESALKCRWHLAVTKTQPQAACKPVRPSGAAEQKYVEKFLRVHGISLQETTRAETGMAYRNLGKSGLRV
SCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEG
LKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQL
PELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNS
LSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLL
LLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGE

--------------------------------------------------------------
>41346_41346_5_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000490337_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2182nt_BP=929nt
AGAAAAATCAATTCAGATTACTTTGATGACAGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGC
GGGGAGTCAGATCTCAGAGGAGAACACCAAGTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTC
AGAAAACGCTAAAGACAGCAGCCTTAGTCCCTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAA
CTGGTACCTAAAGCTCTGCGACCTGTCCAGCGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACT
CAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTA
TGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGG
CTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTAT
TGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGCAAATCGACCGGACAGTAACACTCCCATGGA
AGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGA
AGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGT
CCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGA
CAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCG
AACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAA
CAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCT
GGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGA
GACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAG
GCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGG
ACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCC
TCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGC
GGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGG
CGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGG
ACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGG
ATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAA
AAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAGGAATTTATGTTGCGATTTTTAAAATACTATAGG

>41346_41346_5_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000490337_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=631AA_BP=288
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYH
LFQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVP
WLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA
LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVV
LRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNAB1-LRTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNAB1-LRTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNAB1-LRTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource